Diabetes insipidus

Amikacin

Glycosuria

Splay (physiology)

Hyperglycemia

History of diabetes

Organic anion transporter 1

Glossary of diabetes

Urine test strip

Insulin

Proteinuria

Diabetes

Sucrose

Hyperglycemia12

• The first sign of diabetes is the elevation of glucose level in blood (hyperglycemia). (exclusivepapers.com)
• To analyze the potential of insulin-independent blood glucose control, the effects of the novel SGLT2 inhibitor canagliflozin on renal glucose reabsorption and the progression of hyperglycemia were analyzed in Zucker diabetic fatty (ZDF) rats. (aspetjournals.org)
• It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA). (fpnotebook.com)
• The researchers noted, 'Hyperglycemia and its resultant glycosuria have been implicated in altered renal handling of calcium, phosphorus, and uric acid. (diabetesincontrol.com)
• Hyperglycemia , hyperglycaemia , or high blood sugar is a condition in which an excessive amount of glucose circulates in the blood plasma . (bionity.com)
• nonhyperglycemic g. presence of glucose in the urine without hyperglycemia due to abnormality in renal tubular reabsorption of filtered glucose. (academic.ru)
• This situation is called hyperglycemia and it can lead even to glucose excretion in urine (glycosuria). (diachrom.com)
• How does hyperglycemia cause glycosuria? (brainscape.com)
• Destruction of beta cells leads to a decrease in insulin production, unchecked glucose production by the liver and fasting hyperglycemia. (nurseslabs.com)
• The first stroke of saccharine disease is an increase of glucose concentration in blood, so called hyperglycemia, and, as a result, its urinary excretion (glycosuria). (bestessayservice.org)
• The onset of this condition is during adulthood and is characterized by hyperglycemia (increased blood glucose) as a result of low production of insulin from the pancrease and insulin resistance or overproduction of glucose for example during breakdown of glycogen. (studentshare.net)
• By reducing renal glucose reabsorption as a result of enhancing urinary glucose excretion, SGLT2 inhibitors lower the hyperglycemia that contributes to insulin resis?tance and diminished insulin secretion. (statpathway.com)

Glucosuria9

• Glycosuria or glucosuria is the excretion of glucose into the urine. (wikipedia.org)
• Alimentary glycosuria is a temporary condition, when a high amount of carbohydrate is taken, it is rapidly absorbed in some cases where a part of the stomach is surgically removed, the excessive glucose appears in urine producing glucosuria. (wikipedia.org)
• Some people, especially children and pregnant women, may have a low RTG (less than ~7 mmol/L glucose in blood to have glucosuria). (wikipedia.org)
• Glycosuria - or glucosuria is an abnormal condition of osmotic diuresis due to excretion of glucose by the kidneys.The most common cause of glycosuria is untreated diabetes mellitus. (academic.ru)
• Glucosuria may occur immediately after eating a high-carbohydrate meal, and in patients with otherwise normal glucose levels or prediabetic patients receiving dextrose-containing intravenous (IV) fluids. (the-healthcare.org)
• Further, glucosuria does not always indicate diabetes but can occur normally or in diseases that affect the renal tubule or in genetic defects in metabolism and excretion of glucose. (the-healthcare.org)
• Medical term for sugar in the urine is Glycosuria or glucosuria, it is the excretion of excessive blood glucose into the urine filtrate. (bloodtestsresults.com)
• Renal glucosuria is the excretion of glucose in the urine in the presence of normal plasma glucose levels. (merckmanuals.com)
• Historically, glucosuria glucose excretion while in the urine has become viewed as a marker of metabolic decompensation and an adverse clinical consequence inside the normal background of diabetes. (statpathway.com)

SGLT216

• Glycosuria can be induced therapeutically for treatment of diabetes mellitus type 2 using SGLT2 inhibitors canagliflozin, dapagliflozin, and empagliflozin (collectively known as gliflozins). (wikipedia.org)
• Dugs that target the sodium-glucose cotransporter-2 (SGLT2), which promotes glucose absorption in the kidney have been attractive for use a add-ons to metformin treatment. (eurekalert.org)
• In this issue of the Journal of Clinical Investigation , two research groups led by Ralph DeFronzo of the University of Texas and Ele Ferrannini of the University of Pisa independently report on clinical studies testing the ability SGLT2 inhibitors to reduce plasma glucose levels in T2D patients. (eurekalert.org)
• OBJECTIVE Sodium-glucose cotransporter 2 (SGLT2) inhibitors cause substantially less weight loss than expected from the energy excreted via glycosuria. (diabetesjournals.org)
• Sodium-glucose cotransporter 2 (SGLT2), a low-affinity, high-capacity transporter located on the brush-border of cells in the S1-S2 segment of the proximal convoluted tubule, is the most important mediator of glucose reabsorption from the glomerular filtrate ( 4 ). (diabetesjournals.org)
• Sodium-glucose cotransporter 2 (SGLT2) plays a major role in renal glucose reabsorption. (aspetjournals.org)
• The potential mechanism by which sodium-glucose cotransporter 2 (SGLT2) inhibitors prevent cardiovascular disease (CVD) is being widely investigated. (bvsalud.org)
• Besides lowering glucose, empagliflozin, a selective sodium-glucose cotransporter-2 (SGLT2) inhibitor, have been known to provide cardiovascular and renal protection due to effects on diuresis and natriuresis. (figshare.com)
• In SGLT2-induced glycosuria, the creatinine clearance and fractional glucose excretion is higher in diabetes patients who are overweight or obese. (adahighlights2018.com)
• 2,3 The implementation of SGLT2 inhibitors raises endogenous glucose production, lowers tissue glucose disposal, and stimulates lipolysis and ketogenesis. (adahighlights2018.com)
• This SGLT2-induced glycosuria leads to a shift in oxidative metabolism from carbohydrates to lipids. (adahighlights2018.com)
• Approximately 10% of renal glucose re-absorption occurs via SGLT1, and the remaining 90% occurs via SGLT2, which is found in the early proximal tubule. (bjcardio.co.uk)
• SGLT2, a high-capacity, low-affinity transporter of glucose and sodium is found in high concentration at the brush border membrane of the S1 and S2 segment of the proximal convoluted tubule (PCT). (bjcardio.co.uk)
• SGLT2 binds to sodium and glucose in the filtrate and these compounds are translocated across the apical cell membrane, an active process driven by the electrochemical sodium gradient between tubular filtrate and the cell. (bjcardio.co.uk)
• The Role of Kidney in Glucose Homeostasis - SGLT2 Inhibitors, a New Approach in Diabetes Treatment. (amazonaws.com)
• Aglycone Exploration of C-arylglucoside Inhibitors of Renal Sodium-dependent Glucose Transporter SGLT2. (amazonaws.com)

Urinary glucose7

• However, in virtually all clinical trials, the observed weight loss has been consistently less than expected from the amount of urinary glucose excretion ( 25 , 26 ). (diabetesjournals.org)
• There was a strong correlation between the decrease in blood glucose level (0 to 6 hours post treatment) and the excretion of urinary glucose. (marketwired.com)
• however, urinary glucose appeared before the onset of diabetes. (springer.com)
• To clarify the genetic basis of urinary glucose, we performed genetic linkage analysis using (BN × LEA) F 2 intercross progeny. (springer.com)
• A recessively acting locus responsible for urinary glucose excretion ( ugl ) was mapped to a 7.9 Mb region of chromosome 10, which contains the cystinosin ( Ctns ) gene. (springer.com)
• Phenotypic analysis of F344- Ctns ugl rats indicated that the incidence of urinary glucose was 100% in both males and females at around 40 weeks of age, and marked cystine accumulation was observed in the tissues, as well as remarkable renal lesions and cystine crystals in the lysosomes of the renal cortex. (springer.com)
• Large amounts of urine with a strong odor, a possible indicator of diabetes mellitus, were frequently observed, and urinary glucose was detected in both male and female LEA/Tohm rats. (springer.com)

Reabsorption of glucose5

• Additionally, the tubular function can reduce the reabsorption of glucose, leading to glycosuria. (news-medical.net)
• In the kidneys, SGLT inhibitors reduce the reabsorption of glucose into the bloodstream by eliminating excess glucose into the urine. (marketwired.com)
• phlorizin g., phloridzin g. the presence of sugar in the urine after the experimental administration of phlorizin , which results in a lower renal threshold for glucose reabsorption of glucose. (academic.ru)
• The kidney plays a pivotal purpose in glucose homeo?stasis by regulating the reabsorption of glucose back into the plasma after filtration with the blood. (statpathway.com)
• The reabsorption of glucose is ensured by the sodium-glucose cotransporter (SGLT) 2, responsible for the reabsorption of 90% of glucose, and SGLT1, that reabsorbs the remaining glucose .Despite the large amount of data regarding the implication of the kidneys in glucose homeostasis, this organ is often overlooked as a key player in glucose metabolism. (amazonaws.com)

Inhibitors5

• Recently, of renal nerves in rats using wire hook electrodes at low sodium-glucose co-transporter 2 (SGLT-2) inhibitors were frequencies (0.5-10 Hz) showed increased renin secretion approved by the US Food and Drug Administration (FDA) and water reabsorption, and decreased renal blood flow for patients with type 2 diabetes. (deepdyve.com)
• Diabetic ketoacidosis (DKA) has been associated with the use of sodium glucose cotransporter 2 inhibitors (SGLT2is). (medscape.com)
• Sodium glucose cotransporter 2 inhibitors (SGLT2is) have changed the management of type 2 diabetes, especially for those with established cardiovascular disease. (medscape.com)
• Recently, two large randomized controlled trials which only included patients with underlying cardiovascular disease (CVD) or patients at high risk for CVD showed that two sodium glucose co-transporter 2 inhibitors (SGLT-2is) significantly reduced hospitalization for heart failure (hHF), with an early separation in the survival curves for hHF. (biomedcentral.com)
• The investigations carried out therefore far on sodium glucose co transporter two inhibitors have elucidated new perspectives not only within the mechanism of diabetes, but additionally on prospective therapeutic applications of this expertise. (statpathway.com)

Osmotic diuresis2

• Glycosuria leads to excessive water loss into the urine with resultant dehydration, a process called osmotic diuresis. (wikipedia.org)
• Excessive loss of fluids is accompanied by excessive excretion of glucose in the urine leading to osmotic diuresis. (nurseslabs.com)

Proteinuria and glycosuria2

• On a routine physical examination proteinuria and glycosuria were found. (annals.org)
• Initial laboratory data include a urinalysis showing 3+ proteinuria and glycosuria. (cdc.gov)

Presence of glucose5

• presence of glucose in the urine, as in diabetics. (thefreedictionary.com)
• presence of glucose in the urine, especially the excretion of an abnormally large amount of sugar (glucose) in the urine. (fpnotebook.com)
• For many years it has been established practice to test the urine of pregnant women for the presence of glucose in the belief that this is an efficient way to detect diabetes mellitus. (diabetesjournals.org)
• gly·cos·uria (gli″ko-suґre- ə ) [ glycose, older variant of glucose + - uria ] the presence of glucose in the urine, especially excretion of an abnormally large amount in the urine, such as more than 1 g in 24 hours. (academic.ru)
• This screening test for the presence of glucose within the urine may indicate the likelihood of diabetes mellitus or other causes of glucose intolerance (see Glucose, p. 969). (the-healthcare.org)

Absorption10

• The rate of glucose absorption is dependent on the size of the meal as well as the length of time which has passed since the meal. (mendosa.com)
• The glucose absorption graph highlights the systemic appearance of glucose following a carbohydrate meal. (mendosa.com)
• Presented here are methods using alpha-methylglucoside (AMG) in vivo as an indicator for glucose absorption from the gastrointestinal (GI) system or glucose excretion in the urine after oral administration of AMG. (patentsencyclopedia.com)
• The methods find use in, for example, but not limited to, determining the effect of a sodium-dependent glucose transporter (SGLT) inhibitor in an animal, comparing the differences in the effects of a first and second SGLT inhibitor in an animal, and diagnosing a disease associated with glucose absorption from the gastrointestinal (GI) system or glucose excretion from the kidney in an animal. (patentsencyclopedia.com)
• This invention relates to a method of using alpha-methylglucoside (AMG) in vivo as an indicator for glucose absorption from the gastrointestinal (GI) system, glucose re-absorption from the kidney tubules, and/or glucose excretion in the urine, after oral administration of AMG. (patentsencyclopedia.com)
• The second stage of re-absorption is the transport of glucose through the utilisation of GLUT2 transporters in the basolateral membrane. (bjcardio.co.uk)
• In poorly controlled diabetes, the threshold for re-absorption is exceeded resulting in glycosuria. (bjcardio.co.uk)
• The major sources of the glucose that circulates in the blood are through the absorption of ingested food in the gastrointestinal tract and formation of glucose by the liver from food substances. (nurseslabs.com)
• Hypophosphatemia is caused by the intracellular shift of phosphate from serum, increased urinary excretion of phosphate, decreased intestinal absorption of phosphate, or decreased dietary intake. (medscape.com)
• Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose Absorption and Glucose-dependent Incretin Secretion. (amazonaws.com)

Mmol5

• Existing diabetes and gestational diabetes were associated with higher offspring fasting glucose levels (0.24 mmol/L [95% CI 0.03-0.and 0.20 mmol/L [0.02-0. respectively). (diabetesjournals.org)
• RESEARCH DESIGN AND METHODS Eighty-six patients with type 2 diabetes (HbA 1c 7.8 ± 0.8% [62 ± 9 mmol/mol], estimated glomerular filtration rate [eGFR] 89 ± 19 mL ⋅ min −1 ⋅ 1.73 m −2 ) received empagliflozin (25 mg/day) for 90 weeks with frequent ( n = 11) assessments of body weight, eGFR, and fasting plasma glucose (FPG). (diabetesjournals.org)
• This option switches the units for handling blood glucose values from mmol/L (the standard in some countries, e.g. the UK) to mg/dL (the standard in other countries, e.g. the USA). (mendosa.com)
• In fasting adults, blood plasma glucose should not exceed 126 mg/dL or 7 mmol/L. Sustained higher levels of blood sugar cause damage to the blood vessels and to the organs they supply, leading to the complications of diabetes. (bionity.com)
• All these mechanisms considerably reduce the level of blood glucose, so that it is maintained within its normal levels of between 4.0 and 7.0 mmol/l in the fasting state. (devtome.com)

Urine glucose10

• We hypothesized that stimulation of renal nerves at kilohertz frequencies, which can block propagation of action potentials, would increase urine glucose excretion. (deepdyve.com)
• Conversely, we hypothesized that low frequency stimulation, which has been shown to increase renal nerve activity, would decrease urine glucose excretion. (deepdyve.com)
• No trends or statistical significance were observed for urine glucose concentrations. (deepdyve.com)
• Conclusion: To our knowledge, this is the first study to investigate electrical stimulation of renal nerves to modulate urine glucose excretion. (deepdyve.com)
• Our experimental results show that stimulation of renal nerves may modulate urine glucose excretion, however, this response may be associated with urine flow rate. (deepdyve.com)
• low frequencies (0.5-10 Hz) would decrease urine glucose Khunti et al. (deepdyve.com)
• In many cases, Urine Glucose test may be performed at specified times during the day, usually before meals and at bedtime. (the-healthcare.org)
• In other words, the Urine Glucose test should show negative results. (the-healthcare.org)
• High Urine Glucose levels occur if the total glucose found in urine exceeds 5 grams when 24 hours testing is applied. (the-healthcare.org)
• Blood or urine glucose monitoring is recommended in patients who are at risk of hypoglycemia or who do not recognize the signs and symptoms of hypoglycemia. (drugs.com)

Normal blood glucose3

• If the RTG is so low that even normal blood glucose levels produce the condition, it is referred to as renal glycosuria. (wikipedia.org)
• Despite a normal blood glucose concentration, the kidney cannot reabsorb the normal glucose load. (the-healthcare.org)
• What does glycosuria in the presence of normal blood glucose (renal glycosuria) imply? (brainscape.com)

Renal tubules3

• renal glycosuria glycosuria due to inability of the renal tubules to reabsorb glucose completely. (thefreedictionary.com)
• Recurring or persistent glycosuria in association with blood sugar levels that are in the normal range, resulting from the failure of renal tubules to reabsorb glucose at a normal rate from the glomerular filtrate. (thefreedictionary.com)
• Normally, all of the glucose is reabsorbed in the proximal renal tubules. (the-healthcare.org)

Concentrations4

• As the definition of diabetes mellitus is based on random blood glucose values or the concentrations achieved at defined times after an oral glucose load, it would seem logical that any antenatal screening procedure should be similarly based. (diabetesjournals.org)
• On days 1 and 5, trauma patients had an increase in glycosuria, in urine iron concentration, and in the concentrations of several amino acids compared to healthy volunteers. (biomedcentral.com)
• Diabetes mellitus is a disorder characterised by abnormally high concentrations of glucose in the blood (hyperglycaemia) and in the urine. (devtome.com)
• Excretion is the removal of nitrogenous waste products and other metabolites from the animal body which is normally associated with the process of maintenance of osmibtic concentrations, i.e., osmoregulation within the body. (evidyarthi.in)

Concentration4

• A total of 2403 consecutive antenatal patients had a random venous whole blood glucose concentration determined between 28 and 32 wk gestation. (diabetesjournals.org)
• In the glomerular filtrate, the glucose concentration is the same as in the blood. (the-healthcare.org)
• Glucose is then transported passively by GLUT2 along its concentration gradient into the interstitium. (bjcardio.co.uk)
• The body, and in particular the brain, is extremely sensitive to the concentration of glucose in the blood and function is impaired when the level of blood sugar rises above or drops below certain limits. (devtome.com)

Gestational6

• OBJECTIVE To assess associations of gestational diabetes, existing diabetes, and glycosuria with adiposity and cardiometabolic risk factors in offspring at adolescence. (diabetesjournals.org)
• The aim of the study was to examine the association of existing diabetes (i.e. already diagnosed prior to pregnancy), gestational diabetes and glycosuria (both diagnosed and ascertained during pregnancy) with birthweight and future offspring BMI, waist circumference and fat mass (assessed by dual x-ray emission absorptiometry). (springer.com)
• Adjusted odds ratios for macrosomia were 3.56 (95% CI 1.53-8.28), 5.50 (95% CI 1.18-10.30) and 1.58 (95% CI 1.18-2.12) for existing diabetes, gestational diabetes and glycosuria, respectively. (springer.com)
• Among 6,842 mother-offspring pairs with anthropometric measurements at age 9-11 years, maternal gestational diabetes and glycosuria (but not existing diabetes) were associated with increased offspring odds of general or central overweight/obesity. (springer.com)
• For gestational diabetes, these associations attenuated towards the null with adjustment for maternal prepregnancy BMI, but independent associations remained for glycosuria. (springer.com)
• With gestational diabetes mellitus (GDM) , the pregnant woman experiences any degree of glucose intolerance with the onset of pregnancy . (nurseslabs.com)

Serum Glucose2

• It's possible to have a serum glucose over 200 with none in the urine , but the higher above 200 the serum glucose gets, the less likely none shows up in the urine. (healthtap.com)
• In men and women with diabe?tes, what was as soon as an adaptive method gets to be damaging, as glucose reabsorption may raise up to 20% and perpetu?ate continued elevation in serum glucose levels. (statpathway.com)

Glomerular3

• A proximal action of metolazone has been shown in humans by increased excretion of phosphate and magnesium ions and by a markedly increased fractional excretion of sodium in patients with severely compromised glomerular filtration. (drugs.com)
• Patients with microalbuminuria and early decline in glomerular filtration rate had higher fractional excretion of thiamine compared to patients with stable renal function. (clinicaltrials.gov)
• Having a glomerular filtration rate of 180 liters per day, it filters approximately 180 grams of glucose per day, bringing its contribution in maintaining normal fasting plasma glucose (FPG) levels . (amazonaws.com)

Diabetes or glycosuria2

• There was little evidence of an association of maternal diabetes or glycosuria with offspring dBP, sBP, lipids, or CRP. (diabetesjournals.org)
• The adjusted odds ratio for general overweight/obesity when comparing women with at least two episodes of ++ glycosuria with those with no evidence of diabetes or glycosuria was 1.35 (95% CI 1.00-1.82) and that for central obesity (top 10% waist circumference vs all others) was 1.31 (95% CI 1.00-1.72). (springer.com)

Diabetic patients3

• Our time, which makes achieving blood glucose control targets hypothesis was that direct stimulation of renal nerves at difficult for many diabetic patients (Blak et al. (deepdyve.com)
• The researchers observed an increase in urinary calcium and phosphorous excretion in type 2 diabetic patients. (diabetesincontrol.com)
• In contrast, diabetic patients with glycosuria had a null prevalence of hyperuricemia and excreted more uric acid and Na than diabetic subjects without glycosuria. (biomedsearch.com)

Urinalysis1

• A qualitative glucose test is part of routine urinalysis. (the-healthcare.org)

Ketones2

• [ 4 ] Additionally, it has been suggested that SGLT2is may reduce renal excretion of ketones [ 5 ] and increase ketone production. (medscape.com)
• Is it possible to have ketones/glucose found in urine but not blood glusose level elevated?How? (healthtap.com)

Potassium2

• SGLTs transport sodium and glucose into cells using the sodium gradient created by sodium/potassium ATPase pumps at the basolateral cell membranes. (bjcardio.co.uk)
• Increased sodium load at the distal renal tubule indirectly increases potassium excretion via the sodium-potassium exchange mechanism, hypokalemia and hypochloremia can occur, leading to mild metabolic alkalosis. (wellrx.com)

Excessive blood glucose1

• Diabetes is a condition characterized by excessive blood glucose leading to excretion of excess glucoses in urine giving the urine a characteristic sweet taste a condition clinically referred so as glycosuria. (studentshare.net)

Albumin excretion1

• The urinary microalbumin test measures the rate of albumin excretion in the urine using laboratory tests. (nursingcrib.com)

Fractional excret1

• At 12 weeks of treatment, empagliflozin-treated diabetic rats produced still high urine volume and glycosuria, and showed significantly higher electrolyte-free water clearance than lixisenatide or voglibose-treated diabetic rats without significant change of serum sodium level and fractional excretion of sodium. (figshare.com)

Interstitial glucose levels2

• Administration of uncooked cornstarch (1.25 g/kg body weight) at bedtime was associated with significant improvement of interstitial glucose levels (p (bvsalud.org)
• Continuous glucose monitoring (CGM) endpoints at week 24 showed improvements in mean 24-h interstitial glucose levels for both dapagliflozin groups, compared to placebo, in both DEPICT studies. (adahighlights2018.com)

Sodium-glucose co-transporters2

• Despite the progress in the development presence of sodium-glucose co-transporters (SGLTs) in of diabetic medications, many lose their effectiveness over the renal proximal tubule (Mather and Pollock 2011). (deepdyve.com)
• Almost all of this is re-absorbed into the circulation via sodium glucose co-transporters (SGLTs). (bjcardio.co.uk)

Creatinine2

• Uromodulin excretion was 25 (11-42) mg/g creatinine. (asnjournals.org)
• In this time, the levels of urea and creatinine decrease as a result of the increase renal excretion. (news-medical.net)

Kidney in glucose6

• Bruns, Tim 2018-05-29 00:00:00 Background: The role of the kidney in glucose homeostasis has gained global interest. (deepdyve.com)
• The role of the kidney in glucose homeostasis has recently gained renewed attention. (diabetesjournals.org)
• Renal glucose managing and SGLT The purpose of your kidney in glucose balance continues to be insuf?ficiently appreciated, nonetheless, it is actually no significantly less crucial. (statpathway.com)
• The Role of the Kidney in Glucose HomeostasisMaria Mota1, Eugen Mota2 and Ilie-Robert Dinu2 Department of Diabetes, Nutrition, Metabolic Diseases, University of Medicine and Pharmacy Craiova, Romania Department of Nephrology, University of Medicine and Pharmacy Craiova, Romania1. (amazonaws.com)
• IntroductionIt is only in recent years that the attention was drawn on the important role of the kidney in glucose homeostasis. (amazonaws.com)
• Early non-human studiesThe first researchers in this field, Bergman and Drury brought the first clues about the involvement of the kidney in glucose homeostasis in 1938 . (amazonaws.com)

Thiazide1

• Thiazide diuretics increase the excretion of water by inhibiting the reabsorption of sodium and chloride ions at the distal renal tubule. (empowerpharmacy.com)

Carbohydrates1

• 2. Urinary excretion of carbohydrates . (academic.ru)

Reabsorb the glucose1

• When the blood glucose level exceeds the capability of the renal threshold to reabsorb the glucose (about 180 mg/dL), it begins to spill over into the urine (glycosuria). (the-healthcare.org)

Excrete glucose1

• When the blood glucose level exceeds about 160-180 mg/dl, the proximal tubule becomes overwhelmed and begins to excrete glucose in the urine. (wikipedia.org)

Disorders1

• it results from either an acquired or an inherited, isolated defect in glucose transport or occurs with other renal tubule disorders . (merckmanuals.com)

Metabolic1

• But the awareness of the renal mechanisms of glucose control is likely to increase due to the development of new types of glucose-lowering drugs that target this metabolic pathway .2. (amazonaws.com)

Type 2 diabet4

• VANCOUVER, BRITISH COLUMBIA--(Marketwire - Feb. 23, 2012) - Sirona Biochem Corp. (TSX VENTURE:SBM)(PINKSHEETS:SRBCF)(FRANKFURT:ZSB), announced today its lead compound for the treatment of Type 2 diabetes was effective in lowering blood glucose levels in a well-established preclinical diabetic model. (marketwired.com)
• After delivery , blood glucose levels in women with GDM usually return to normal or later on develop type 2 diabetes. (nurseslabs.com)
• The current approach to the treatment of both type 1 and type 2 diabetes is to achieve the best possible glucose control. (diabetesjournals.org)
• In addition to drugs that have indications for treatment of type 2 diabetes, several anti-obesity drugs have been studied in patients with type 2 diabetes, for their effects on both weight and glucose control. (diabetesjournals.org)

Inhibitor2

• SBM-TFC-039 is a sodium glucose transporter (SGLT) inhibitor. (marketwired.com)
• 8. A method for comparing the differences in the effects of a first and second sodium-dependent glucose transporter (SGLT) inhibitor, comprising the steps ofa. (patentsencyclopedia.com)

Sugar in the urine1

• glycosuria - [ˌglʌɪkə(ʊ) sjʊərɪə] noun Medicine a condition characterized by an excess of sugar in the urine, typically associated with diabetes or kidney disease. (academic.ru)