Glucokinase: A group of enzymes that catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate. They are found in invertebrates and microorganisms, and are highly specific for glucose. (Enzyme Nomenclature, 1992) EC 2.7.1.2.Liver: A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Gene Expression Regulation, Enzymologic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.Hexokinase: An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.Glucagon: A 29-amino acid pancreatic peptide derived from proglucagon which is also the precursor of intestinal GLUCAGON-LIKE PEPTIDES. Glucagon is secreted by PANCREATIC ALPHA CELLS and plays an important role in regulation of BLOOD GLUCOSE concentration, ketone metabolism, and several other biochemical and physiological processes. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p1511)Diabetes Mellitus, Type 2: A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Introns: Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Enzyme Induction: An increase in the rate of synthesis of an enzyme due to the presence of an inducer which acts to derepress the gene responsible for enzyme synthesis.Rats, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.Mannoheptulose: A 7-carbon keto sugar having the mannose configuration.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Dihydroxyacetone: A ketotriose compound. Its addition to blood preservation solutions results in better maintenance of 2,3-diphosphoglycerate levels during storage. It is readily phosphorylated to dihydroxyacetone phosphate by triokinase in erythrocytes. In combination with naphthoquinones it acts as a sunscreening agent.Glucose Transporter Type 2: A glucose transport facilitator that is expressed primarily in PANCREATIC BETA CELLS; LIVER; and KIDNEYS. It may function as a GLUCOSE sensor to regulate INSULIN release and glucose HOMEOSTASIS.Ninhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.FructosephosphatesGlucose-6-Phosphate: An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)Insulinoma: A benign tumor of the PANCREATIC BETA CELLS. Insulinoma secretes excess INSULIN resulting in HYPOGLYCEMIA.Dinucleotide Repeats: The most common of the microsatellite tandem repeats (MICROSATELLITE REPEATS) dispersed in the euchromatic arms of chromosomes. They consist of two nucleotides repeated in tandem; guanine and thymine, (GT)n, is the most frequently seen.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.PubMed: A bibliographic database that includes MEDLINE as its primary subset. It is produced by the National Center for Biotechnology Information (NCBI), part of the NATIONAL LIBRARY OF MEDICINE. PubMed, which is searchable through NLM's Web site, also includes access to additional citations to selected life sciences journals not in MEDLINE, and links to other resources such as the full-text of articles at participating publishers' Web sites, NCBI's molecular biology databases, and PubMed Central.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.BooksPublishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Insulin-Secreting Cells: A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.MEDLINE: The premier bibliographic database of the NATIONAL LIBRARY OF MEDICINE. MEDLINE® (MEDLARS Online) is the primary subset of PUBMED and can be searched on NLM's Web site in PubMed or the NLM Gateway. MEDLINE references are indexed with MEDICAL SUBJECT HEADINGS (MeSH).Receptors, Retinoic Acid: Proteins in the nucleus or cytoplasm that specifically bind RETINOIC ACID or RETINOL and trigger changes in the behavior of cells. Retinoic acid receptors, like steroid receptors, are ligand-activated transcription regulators. Several types have been recognized.Tretinoin: An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).Retinoid X Receptors: A subtype of RETINOIC ACID RECEPTORS that are specific for 9-cis-retinoic acid which function as nuclear TRANSCRIPTION FACTORS that regulate multiple signaling pathways.Diet, Protein-Restricted: A diet that contains limited amounts of protein. It is prescribed in some cases to slow the progression of renal failure. (From Segen, Dictionary of Modern Medicine, 1992)Fetal Nutrition Disorders: Disorders caused by nutritional imbalance, either overnutrition or undernutrition, in the FETUS in utero.DNA Methylation: Addition of methyl groups to DNA. DNA methyltransferases (DNA methylases) perform this reaction using S-ADENOSYLMETHIONINE as the methyl group donor.CpG Islands: Areas of increased density of the dinucleotide sequence cytosine--phosphate diester--guanine. They form stretches of DNA several hundred to several thousand base pairs long. In humans there are about 45,000 CpG islands, mostly found at the 5' ends of genes. They are unmethylated except for those on the inactive X chromosome and some associated with imprinted genes.Epigenesis, Genetic: A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.Methylation: Addition of methyl groups. In histo-chemistry methylation is used to esterify carboxyl groups and remove sulfate groups by treating tissue sections with hot methanol in the presence of hydrochloric acid. (From Stedman, 25th ed)Chlorpropamide: A sulfonylurea hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. (From Martindale, The Extra Pharmacopoeia, 30th ed, p277)Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Blood Glucose: Glucose in blood.Diabetes Mellitus, Type 1: A subtype of DIABETES MELLITUS that is characterized by INSULIN deficiency. It is manifested by the sudden onset of severe HYPERGLYCEMIA, rapid progression to DIABETIC KETOACIDOSIS, and DEATH unless treated with insulin. The disease may occur at any age, but is most common in childhood or adolescence.Research Personnel: Those individuals engaged in research.
"GCK glucokinase [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2016-06-12. "MSOE Center for ... Another example is Glucokinase, which is an enzyme involved in the phosphorylation of glucose to glucose-6-phosphate. It is ... Sener, A; Giroix, M H; Dufrane, S P; Malaisse, W J (1985-09-01). "Anomeric specificity of hexokinase and glucokinase activities ...
Several of the defects are mutations of transcription factor genes. One form is due to mutations of the glucokinase gene. For ... In some cases, there are significant differences in the activity of the mutant gene product that contribute to variations in ... MODY2: Homozygous glucokinase deficiency causes severe congenital insulin deficiency resulting in persistent neonatal diabetes ... March 2005). "Role of transcription factor KLF11 and its diabetes-associated gene variants in pancreatic beta cell function". ...
Hepatic fructokinase PFKL PFKM PFKP Glucokinase Hexokinase DBGET ENZYME: 2.7.1.4. Retrieved 2007-05-06 Odanaka S, Bennett AB, ... There are also two divergent fructokinase genes that are differentially expressed and which also have different enzymatic ... Kanayama Y (July 2002). "Distinct physiological roles of fructokinase isozymes revealed by gene-specific suppression of Frk1 ...
"Entrez Gene: NAGK N-acetylglucosamine kinase". Ligos JM, de Lera TL, Hinderlich S, Guinea B, Sánchez L, Roca R, Valencia A, ... suppression of glucokinase in cirrhosis". Biochimica et Biophysica Acta. 1379 (1): 134-42. doi:10.1016/s0304-4165(97)00092-5. ... N-acetyl-D-glucosamine kinase is an enzyme that in humans is encoded by the NAGK gene. N-acetylglucosamine kinase (NAGK; EC 2.7 ... Gene. 138 (1-2): 171-4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. Weidanz JA, Campbell P, Moore D, DeLucas LJ, Rodén L, ...
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 is an enzyme that in humans is encoded by the PFKFB2 gene. The protein ... 2001). "Characterization of glucokinase-binding protein epitopes by a phage-displayed peptide library. Identification of 6- ... Two transcript variants encoding two different isoforms have been found for this gene. PFKFB2 has been shown to interact with ... This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene ...
"Entrez Gene: HK3 hexokinase 3 (white cell)". Murakami K, Kanno H, Tancabelic J, Fujii H (2002). "Gene expression and biological ... suppression of glucokinase in cirrhosis". Biochimica et Biophysica Acta. 1379 (1): 134-42. doi:10.1016/s0304-4165(97)00092-5. ... This gene encodes hexokinase 3. Similar to hexokinases 1 and 2, this allosteric enzyme is inhibited by its product glucose-6- ... Hexokinase 3 also known as HK3 is an enzyme which in humans is encoded by the HK2 gene on chromosome 5. Hexokinases ...
... n repeat element maps the human glucokinase gene (GCK) to chromosome 7p". Genomics. 12 (2): 319-25. doi:10.1016/0888-7543(92) ... "Nonsense mutation in the glucokinase gene causes early-onset non-insulin-dependent diabetes mellitus". Nature. 356 (6371): 721- ... The protein encoded by this gene is a member of the serine/threonine protein kinase family. Although this kinase is found in ... "Entrez Gene: MAP4K2 mitogen-activated protein kinase kinase kinase kinase 2". Meng, Zhipeng; Moroishi, Toshiro; Guan, Kun-Liang ...
"Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression". Journal of Clinical ... Since beta cells use glucokinase to catalyze the first step of glycolysis, metabolism only occurs around physiological blood ... Lang V, Light PE (2010). "The molecular mechanisms and pharmacotherapy of ATP-sensitive potassium channel gene mutations ...
1995). "Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression." The Journal of Clinical ...
... is due to any of several mutations in the GCK gene on chromosome 7 for glucokinase. Glucokinase serves as the glucose ... The abnormal gene "dominates" the pair of genes. If just one parent has a dominant gene defect, each child has a 50% chance of ... Dominant inheritance means an abnormal gene from one parent is capable of causing disease, even though the matching gene from ... When both GCK genes are affected the diabetes appears earlier and the hyperglycemia is more severe. A form of permanent ...
The part of the glucose entering the liver is phosphorylated by glucokinase and then dephosphorylated by G-6-Pase. This futile ... Central nesfatin-1 appeared to antagonize the effect of HFD on increasing PEPCK gene expression in vivo. In agreement with ... Because hepatic AMPK controls glucose homeostasis mainly through the inhibition of gluconeogenic gene expression and glucose ... cycle between glucokinase and G-6-Pase is named glucose cycling, and it accounts for the difference between the total flux ...
He identified glucokinase as the first gene causing diabetes and has published over 500 papers on the topic of diabetes. His ...
Genes that encode hexokinase have been discovered in every domain of life, and exist among a variety of species that range from ... Glucokinase can only phosphorylate glucose if the concentration of this substrate is high enough; its Km for glucose is 100 ... Chronic Haemolytic Anaemia is caused by a mutation in the HK gene, which codes for the HK enzyme. The mutation causes a ... Hexokinases should not be confused with glucokinase, which is a specific isoform of hexokinase. While other hexokinases are ...
The activation of MAP-Kinase leads to completion of mitogenic functions like cell growth and gene expression. The activation of ... Inside the beta cell, the following process occurs: Glucose gets converted to Glucose-6-Phosphate (G6P) through Glucokinase; ... PTBP1 enable the insulin gene specific activation and insulin granule protein mRNA by glucose . Two aspects of the transduction ... and specific gene expression of some proteins which will help in the intake of glucose. Different enzymes control this pathway ...
Even in adults it continues to play a role in the regulation and expression of genes for insulin, GLUT2, glucokinase, and ... MODY 4 arises from mutations of the PDX1 homeobox gene on chromosome 13. Pdx-1 is a transcription factor vital to the ...
... where the association of insulin and SREBP-1 lead to the gene expression of glucokinase. The interaction of glucose and ... These genes are then activated for transcription. It has been indicated that SREBP-2 promote the expression of genes involved ... can induce the gene products for liver's pyruvate kinase, acetyl-CoA carboxylase, and fatty acid synthase. These genes are ... Lipogenic gene expression in the liver via glucose and insulin is moderated by SREBP-1. The effect of glucose and insulin on ...
2006). "Polymorphisms in the glucokinase-associated, dual-specificity phosphatase 12 (DUSP12) gene under chromosome 1q21 ... This gene product is the human ortholog of the Saccharomyces cerevisiae YVH1 protein tyrosine phosphatase. It is localized ... "Entrez Gene: DUSP12 dual specificity phosphatase 12". Hasstedt SJ, Chu WS, Das SK, et al. (2008). "Type 2 diabetes ... Dual specificity protein phosphatase 12 is an enzyme that in humans is encoded by the DUSP12 gene. The protein encoded by this ...
The HKDC1 gene is oriented in a head-to-tail arrangement next to the HK1 gene on chromosome 10. This arrangement, along with ... Hexokinase HK1 HK2 HK3 Glucokinase GRCh38: Ensembl release 89: ENSG00000156510 - Ensembl, May 2017 GRCm38: Ensembl release 89: ... Hexokinase domain containing 1 (HKDC1) is an enzyme which in humans is encoded by the HKDC1 gene on chromosome 10. It is a ... Irwin DM, Tan H (March 2008). "Molecular evolution of the vertebrate hexokinase gene family: Identification of a conserved ...
DNA methylation in gene promoter regions usually results in gene silencing and influences gene expression. While this form of ... Feeding a PR-diet to pregnant and/or lactating mice also increased expression of glucokinase, acetyl-CoA carboxylase, PPARα, ... The above is an example of the "agouti" gene locus, whereby the insertion of a transposable element upstream to the Agouti gene ... of the fetal genes analyzed (235/22,690). Specifically, increased expression was seen in genes involved in the p53 pathway, ...
"Entrez Gene: HK2 hexokinase 2". Murakami K, Kanno H, Tancabelic J, Fujii H (2002). "Gene expression and biological significance ... Mitochondria portal Hexokinase HK1 HK3 Glucokinase GRCh38: Ensembl release 89: ENSG00000159399 - Ensembl, May 2017 GRCm38: ... it lacks an open reading frame for gene expression. This gene encodes a 100-kDa, 917-residue enzyme with highly similar N- and ... Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of ...
This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene ... Mitochondria portal Hexokinase HK2 HK3 Glucokinase GRCh38: Ensembl release 89: ENSG00000156515 - Ensembl, May 2017 GRCm38: ... Mutations in this gene are associated with type 4H of Charcot-Marie-Tooth disease, also known as Russe-type hereditary motor ... This gene encodes a 100 kDa homodimer with a regulatory N-terminal domain (1-475), catalytic C-terminal domain (residues 476- ...
Endurance exercise has been shown to activate the PGC-1α gene in human skeletal muscle. This protein may be also involved in ... Thyroid hormone receptor beta ERRalpha and PGC-1α are coactivators of both Glucokinase (GK) and SIRT3, binding to an ERRE ... "Entrez Gene: PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha". Liang H, Ward WF (December 2006 ... Harris CD, Ermak G, Davies KJ (November 2005). "Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product ...
The gene that encodes GLUT4 was cloned and mapped in 1989. At the cell surface, GLUT4 permits the facilitated diffusion of ... Once within cells, glucose is rapidly phosphorylated by glucokinase in the liver and hexokinase in other tissues to form ... In addition, mutations in GLUT4 genes in adipocytes can also lead to increased GLUT4 expression in adipose cells, which allows ... In addition, recent reports demonstrated the presence of GLUT4 gene in central nervous system such as the hippocampus. Moreover ...
Human glucokinase is coded for by the GCK gene on chromosome 7. This single autosomal gene has 10 exons. Genes for glucokinase ... However, glucokinase is coded by a separate gene and its distinctive kinetic properties allow it to serve a different set of ... The gene structure and amino acid sequence are highly conserved among most mammals (e.g., rat and human glucokinase is more ... Mutagens of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia. Glucokinase (GK) is a hexokinase ...
"Functional analysis of human glucokinase gene mutations causing MODY2: exploring the regulatory mechanisms of glucokinase ... December 2006). "An allosteric activator of glucokinase impairs the interaction of glucokinase and glucokinase regulatory ... November 2008). "Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma ... The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in ...
Genes and Disease [Internet]》. Bethesda (MD): National Center for Biotechnology Information (US). 1998-2015.. ... "Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus". 》The New England Journal ... Smith S (December 1994). "The animal fatty acid synthase: one gene, one polypeptide, seven enzymes". 》FASEB Journal》 8 (15): ... "Structural basis for allosteric regulation of the monomeric allosteric enzyme human glucokinase". 》Structure》 12 (3): 429-38. ...
... is associated with mutations in the GCK gene that result in impaired glucokinase activity. Although more than 200 inactivating ... In this work we describe the biochemical characterization of six missense glucokinase mutations associated to MODY2 from ... Biochemical characterization of novel glucokinase mutations isolated from Spanish maturity onset diabetes of the young (MODY2) ... These data add new information on the structure-function relationship of human glucokinase. ...
Mutations in the gene encoding GCK can cause both hyperglycemia and hypoglycemia. Due to the major role of Glucokinase in ... Glucokinase Activity Assay Kit (Fluorometric) (BN01129) Glucokinase Activity Assay Kit (Fluorometric) (BN01129). (No reviews ... Glucokinase (also called GCK, hexokinase type IV or D and ATP: D-hexose 6-phosphotransferase; EC 2.7.1.1) is expressed in ... Assay Genies Glucokinase Activity Assay Kit provides a quick and easy method for monitoring GCK activity in wide variety of ...
Homo sapiens glucokinase (hexokinase 4) regulatory protein (GCKR) gene, complete... Homo sapiens glucokinase (hexokinase 4) ... Gene. 2018] A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for ... A case-control study and meta-analysis confirm glucokinase regulatory gene rs780094 is a risk factor for gestational diabetes ... Homo sapiens glucokinase (hexokinase 4) regulatory protein (GCKR) gene, complete cds. GenBank: AY320034.1 ...
Studies of inheritance of glucokinase genes have revealed significant linkage in families with early-onset NIDDM, or MODY, and ... Now that the human gene has been isolated, this question has been addressed directly. Polymorphic markers flanking the gene ... Glucokinase, the major enzyme that phosphorylates glucose upon entry into liver and islet β-cells, has been considered a prime ... This study considers the phenotypes that result from glucokinase defects and the relationship of MODY to NIDDM, and it ...
... whereas β-cell glucokinase activity is increased by glucose. Recently, the glucokinase gene has been characterized and was ... Glucokinase Gene Structure: Functional Implications of Molecular Genetic Studies Message Subject (Your Name) has forwarded a ... The finding of two different transcription control regions in a single glucokinase gene provides a genetic basis for the tissue ... indicates that at least three glucokinase isoforms are generated by differential RNA processing of the glucokinase gene ...
Polyphosphate glucokinaseAdd BLAST. 265. Proteomic databases. PaxDb, a database of protein abundance averages across all three ... glucokinase activity Source: MTBBASE ,p>Inferred from Direct Assay,/p> ,p>Used to indicate a direct assay for the function, ... Polyphosphate glucokinase1 Publication. ,p>Manually curated information that is based on statements in scientific articles for ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ...
Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression.. De Vos A1, Heimberg H, Quartier ... Studies on rodent beta-cells have suggested a role for GLUT2 and glucokinase in this control function and in mechanisms leading ... These data underline the importance of glucokinase but not of GLUT2 in the glucose sensor of human beta-cells. ... Human beta-cells differ from rodent beta-cells in glucose transporter gene expression (predominantly GLUT1 instead of GLUT2), ...
Cloning of genes that complement yeast hexokinase and glucokinase mutants.. R B Walsh, G Kawasaki, D G Fraenkel ... Cloning of genes that complement yeast hexokinase and glucokinase mutants. Message Subject (Your Name) has forwarded a page to ...
Cloning of genes that complement yeast hexokinase and glucokinase mutants.. R B Walsh, G Kawasaki, D G Fraenkel ... Cloning of genes that complement yeast hexokinase and glucokinase mutants. Message Subject (Your Name) has forwarded a page to ... Genes complementing the glucose-negative fructose-negative Saccharomyces cerevisiae triple mutant strain (hxkl hxk2 glk1), ... which lacks hexokinase PI, hexokinase PII, and glucokinase, were obtained from a pool of yeast DNA in the multicopy plasmid ...
Abstract P218: Identification of One Retinoic Acid Responsive Element in Glucokinase Gene Promoter. Guoxun Chen, Rui Li, Wei ... Abstract P218: Identification of One Retinoic Acid Responsive Element in Glucokinase Gene Promoter ... Abstract P218: Identification of One Retinoic Acid Responsive Element in Glucokinase Gene Promoter ... Abstract P218: Identification of One Retinoic Acid Responsive Element in Glucokinase Gene Promoter ...
... treatment were collected from patients and retrospective case note review of 82 offspring born to 42 women with GCK gene ... To assess determinants of fetal growth in the offspring of pregnant women with hyperglycaemia due to a heterozygous glucokinase ...
Common Missense Variant in the Glucokinase Regulatory Protein Gene Is Associated With Increased Plasma Triglyceride and C- ... Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C- ... Objective: Using the genome-wide association approach, we recently identified the glucokinase regulatory protein gene (GCKR, ... 417-kb region of linkage disequilibrium spanning GCKR and 16 other genes on chromosome 2p23 by imputing untyped HapMap single ...
... ... Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents}, ... Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was ... Recently, the single nucleotide polymorphism (SNP) identified as rs1260326, in the glucokinase regulatory protein (GCKR), was ...
Transcriptional induction of glucokinase gene by. insulin in cultured liver cells and its repression by the glucagon-cAMP ... liver glucokinase gene in newborn rats: relation with DNAse-I hypersensitive sites. European Journal of Biochemistry 215,. 883- ... of glucokinase gene. Experimental and Molecular Medicine 33, 59-63.. Davidson, A.L., Arion, W.J., 1987. Factors underlying ... glucokinase gene by insulin in cultured rat neonatal hepatocytes: relationship with DNAse-I hypersensitive sites and functional ...
A) We analyzed insulin receptor gene and glucokinase gene in 70 late-onset type 2 diabetic patients and 50 healthy control ... 1) Concerning glucokinase gene we found 4 kinds of mutations in 6 cases in diabetc patients. However 3 kinds of mutations were ... Gene analysis of insuiln receptor and glucokinase in patients with non-insulin dependent diabetes mellitus. Research Project ... Publications] Tawata, M.et al.: Variant forms of glucokinase gene in Japanese patients with late-onset type 2 diabetes. Acta ...
A target sequence such as the human glucokinase gene may be amplified with a high specificity, a high speed, a high sensitivity ... and a low cost through a multiplex PCR to detect a maturity-onset of diabetes of the young (MODY) 2 associated gene. ... The present invention provides a primer pool for amplifying a target sequence of a human glucokinase gene including at least ... Amplification of a Human Glucokinase Gene by a Single PCR * Each target sequence of a human glucokinase gene was amplified by a ...
The human glucokinase mutant encoded by the gene has higher activity than that of the wild type human glucokinase, and thus ... Human glucokinase mutant encoded by the gene, the recombinant vectors carrying the gene, the hosts comprising the vectors, ... The gene has the nucleotide sequence chosen from the nucleotide sequence listed as SEQ ID NO:2 and the nucleotide sequence ... The human glucokinase mutant encoded by the gene has higher activity than that of the wild type human glucokinase, and thus ...
Upper airway gene expression differentiates COVID-19 from other acute respiratory illnesses and reveals suppression of innate ... SARS-CoV-2 receptor ACE2 is an interferon-stimulated gene in human airway epithelial cells and is enriched in specific cell ... Bulk and single-cell gene expression profiling of SARS-CoV-2 infected human cell lines identify molecular targets for ... Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene 3 expression in the airway epithelium ...
This protein in other organisms (by gene name): Q91754 - Xenopus laevis 1 * Q99522 - Homo sapiens no matching PDB entries ... Inhibits glucokinase (gck) by forming an inactive complex with this enzyme. The affinity of gckr for gck is modulated by ...
Loss-of-function mutations in the gene encoding GK have been linked to maturity-onset diabetes of the young type 2 (MODY2), an ... Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy Message Subject. (Your Name) has forwarded a page to ... Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy. By Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett ... Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy. By Joseph Grimsby, Ramakanth Sarabu, Wendy L. Corbett ...
Human pancreatic glucokinase (GlkB, hexokinase IV) has been expressed in Saccharomyces cerevisiae. The recombinant protein ... Gene Expression Regulation * Glucokinase / genetics* * Glucokinase / metabolism * Glucose / metabolism * Hexokinase / genetics ... Human pancreatic glucokinase (GlkB) complements the glucose signalling defect of Saccharomyces cerevisiae hxk2 mutants Yeast. ... Human pancreatic glucokinase (GlkB, hexokinase IV) has been expressed in Saccharomyces cerevisiae. The recombinant protein ...
Gene Expression Regulation, Bacterial * Gene Expression Regulation, Enzymologic * Glucokinase / metabolism* * Oxidative Stress ... Glucokinase of Escherichia coli: induction in response to the stress of overexpressing foreign proteins Arch Biochem Biophys. ... The bacterial glucokinase is shown to have a mass of approximately 47 kDa determined by a "renaturation activity stain assay" ... The induced protein identified as glucokinase (EC 2.7.1.2) is produced at a level , or = 20-fold higher than the level in wild- ...
The glucokinase gene promoter polymorphism -30G,A (rs1799884) is associated with fasting glucose in healthy pregnant women but ... Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Darko Stefanovski, Jang H. Youn, Matthew Rees ... Estimating Hepatic Glucokinase Activity Using a Simple Model of Lactate Kinetics. Darko Stefanovski, Jang H. Youn, Matthew Rees ... Glucokinase as glucose sensor and metabolic signal generator in pancreatic beta-cells and hepatocytes. Diabetes 1990;39:647-652 ...
ADP Dependent Glucokinase, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human ... No data available for DME Specific Peptides for ADPGK Gene Domains & Families for ADPGK Gene Gene Families for ADPGK Gene. ... Aliases for ADPGK Gene Aliases for ADPGK Gene. * ADP Dependent Glucokinase 2 3 5 ... Evolution for ADPGK Gene. ENSEMBL:. Gene Tree for ADPGK (if available). TreeFam:. Gene Tree for ADPGK (if available). Aminode: ...
Functional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 ... Functional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 ... Functional characterisation of the glucokinase regulatory protein gene variant P446L shows diminished regulation by fructose-6 ...
  • Due to the major role of Glucokinase in controlling blood glucose homeostasis, Glucokinase is currently considered as a strong candidate target for the treatment of Hyperglycemia, a condition encountered in Type 2 Diabetic patients. (assaygenie.com)
more