Glomus Tympanicum Tumor
Glomus Tympanicum
Paraganglia, Nonchromaffin
Ear Neoplasms
Paraganglioma, Extra-Adrenal
Eustachian Tube
Glomus Tumor
Ear, Middle
X-Ray Intensifying Screens
Glomus Jugulare Tumor
Glomeromycota
Mycorrhizae
Carotid Body
A Glomus Tympanicum Tumor, also known as a paraganglioma of the middle ear, is a rare, benign tumor that develops from the glomus body, which is a small collection of cells located near the middle ear's round window. These tumors typically appear as red or bluish masses behind the eardrum (tympanic membrane) and can cause symptoms such as hearing loss, pulsatile tinnitus (a rhythmic sound in the ear that matches the heartbeat), and vertigo (dizziness).
The growth of these tumors is usually slow, but they can become quite large over time if left untreated. While glomus tympanicum tumors are not cancerous, they can still cause significant problems with hearing and balance due to their location in the middle ear. Treatment options for these tumors typically include surgical removal or radiation therapy. Regular follow-up care is necessary to monitor for any recurrence of the tumor after treatment.
Glomus tympanicum is a small, highly vascular tumor that develops in the middle ear, specifically in the glomus body which is a part of the tympanic plexus (a network of blood vessels) near the hearing bones. It's also known as paraganglioma of the middle ear. These tumors are usually benign but they can cause serious problems due to their location, such as conductive hearing loss, pulsatile tinnitus (a rhythmic buzzing or whooshing sound in the ear), and less commonly, disequilibrium or vertigo. Treatment options include observation, radiation therapy, or surgical removal.
Paraganglia, nonchromaffin are neuroendocrine tissues that originate from the neural crest and are widely distributed throughout the body. They are similar to chromaffin paraganglia (which contain catecholamines) but do not contain catecholamines or only contain them in trace amounts. Instead, they produce and secrete various neuropeptides and hormones, such as serotonin, somatostatin, and calcitonin gene-related peptide (CGRP).
Nonchromaffin paraganglia are divided into two main groups: the head and neck (HNP) and the thoracoabdominal (TAP) paraganglia. The HNP include the carotid body, jugular body, vagal body, and laryngeal paraganglia, while the TAP include the aorticopulmonary, organ of Zuckerkandl, and other abdominal and pelvic paraganglia.
Nonchromaffin paragangliomas are rare tumors that arise from these tissues. They can be functional or nonfunctional, depending on whether they produce and secrete hormones or not. Functional tumors can cause a variety of symptoms due to the excessive release of hormones, while nonfunctional tumors usually present as masses that may compress surrounding structures.
Ear neoplasms refer to abnormal growths or tumors that occur in the ear. These growths can be benign (non-cancerous) or malignant (cancerous) and can affect any part of the ear, including the outer ear, middle ear, inner ear, and the ear canal.
Benign ear neoplasms are typically slow-growing and do not spread to other parts of the body. Examples include exostoses, osteomas, and ceruminous adenomas. These types of growths are usually removed surgically for cosmetic reasons or if they cause discomfort or hearing problems.
Malignant ear neoplasms, on the other hand, can be aggressive and may spread to other parts of the body. Examples include squamous cell carcinoma, basal cell carcinoma, and adenoid cystic carcinoma. These types of tumors often require more extensive treatment, such as surgery, radiation therapy, and chemotherapy.
It is important to note that any new growth or change in the ear should be evaluated by a healthcare professional to determine the nature of the growth and develop an appropriate treatment plan.
Paraganglioma, extra-adrenal, is a type of rare tumor that develops in the nervous system's paraganglia, which are groups of specialized cells that are responsible for regulating blood pressure and other bodily functions. Unlike adrenal paragangliomas, which form in the adrenal glands located on top of the kidneys, extra-adrenal paragangliomas develop outside of the adrenal glands, in various locations along the sympathetic and parasympathetic nervous systems. These tumors can be functional or nonfunctional, meaning they may or may not produce hormones such as catecholamines (epinephrine, norepinephrine, and dopamine). Functional extra-adrenal paragangliomas can cause symptoms related to excessive hormone production, including hypertension, sweating, headaches, and rapid heartbeat. Treatment typically involves surgical removal of the tumor, along with preoperative preparation to manage potential hormonal imbalances.
The Eustachian tube, also known as the auditory tube or pharyngotympanic tube, is a narrow canal that connects the middle ear cavity to the back of the nasopharynx (the upper part of the throat behind the nose). Its function is to maintain equal air pressure on both sides of the eardrum and to drain any fluid accumulation from the middle ear. The Eustachian tube is lined with mucous membrane and contains tiny hair-like structures called cilia that help to move mucus and fluid out of the middle ear. It opens and closes to regulate air pressure and drainage, which typically occurs during swallowing or yawning.
A Glomus tumor is a rare, benign (non-cancerous) neoplasm that arises from the glomus body, a specialized form of blood vessel found in the skin, particularly in the fingers and toes. These tumors are highly vascular and usually appear as small, blue or red nodules just beneath the nail bed or on the fingertips. They can also occur in other parts of the body such as the stomach, lung, and kidney, but these locations are much less common.
Glomus tumors typically present with symptoms like severe pain, especially when exposed to cold temperatures or pressure. The pain is often described as sharp, stabbing, or throbbing, and it can be debilitating for some individuals. Diagnosis of glomus tumors usually involves a physical examination, imaging studies such as MRI or CT scans, and sometimes biopsy. Treatment options include surgical excision, which is often curative, and in some cases, embolization or sclerotherapy may be used to reduce the blood flow to the tumor before surgery.
The middle ear is the middle of the three parts of the ear, located between the outer ear and inner ear. It contains three small bones called ossicles (the malleus, incus, and stapes) that transmit and amplify sound vibrations from the eardrum to the inner ear. The middle ear also contains the Eustachian tube, which helps regulate air pressure in the middle ear and protects against infection by allowing fluid to drain from the middle ear into the back of the throat.
X-ray intensifying screens are medical imaging devices that contain phosphorescent materials, which emit light in response to the absorption of X-ray radiation. They are used in conjunction with X-ray film to enhance the visualization of radiographic images by converting X-rays into visible light. The screens are placed inside a cassette, along with the X-ray film, and exposed to X-rays during medical imaging procedures such as radiography or fluoroscopy.
The phosphorescent materials in the intensifying screens absorb most of the X-ray energy and re-emit it as visible light, which then exposes the X-ray film. This process increases the efficiency of the X-ray exposure, reducing the amount of radiation required to produce a diagnostic image. The use of intensifying screens can significantly improve the quality and detail of radiographic images while minimizing patient exposure to ionizing radiation.
A Glomus Jugulare Tumor is a rare, usually benign, slow-growing tumor that develops from the glomus body, a small collection of modified blood vessels involved in temperature regulation, located near the jugular bulb in the skull. This type of tumor can cause symptoms such as hearing loss, pulsatile tinnitus (a rhythmic sound in the ear), and cranial nerve palsies due to its proximity to critical structures in the head and neck. Treatment typically involves surgical removal or radiation therapy.
Glomeromycota is a phylum of fungi that form arbuscular mycorrhizae, which are symbiotic associations with the roots of most land plants. These fungi exist exclusively as tiny, threadlike structures called hyphae, which penetrate the cells of plant roots and form unique structures called arbuscules where nutrient exchange occurs. The fungi receive carbon from the plant in the form of sugars, while they provide essential mineral nutrients like phosphorus and nitrogen to the plant.
Glomeromycota fungi have a mutualistic relationship with plants, helping them to grow and survive in nutrient-poor soils. They also play a crucial role in soil ecology by promoting aggregate formation, improving soil structure, and increasing its water-holding capacity. These fungi are found worldwide and can be detected in almost all terrestrial ecosystems.
It is worth noting that Glomeromycota fungi lack a sexual reproductive stage, and their identification and classification rely on the morphology of their vegetative structures and molecular data.
Mycorrhizae are symbiotic associations between fungi and the roots of most plant species. In a mycorrhizal association, fungi colonize the root tissues of plants and extend their mycelial networks into the surrounding soil. This association enhances the nutrient uptake capacity of the host plant, particularly with regards to phosphorus and nitrogen, while the fungi receive carbohydrates from the plant for their own growth and metabolism.
Mycorrhizal fungi can be broadly classified into two types: ectomycorrhizae and endomycorrhizae (or arbuscular mycorrhizae). Ectomycorrhizae form a sheath around the root surface, while endomycorrhizae penetrate the root cells and form structures called arbuscules, where nutrient exchange occurs. Mycorrhizal associations play crucial roles in maintaining ecosystem stability, promoting plant growth, and improving soil structure and fertility.
The carotid body is a small chemoreceptor organ located near the bifurcation of the common carotid artery into the internal and external carotid arteries. It plays a crucial role in the regulation of respiration, blood pressure, and pH balance by detecting changes in the chemical composition of the blood, particularly oxygen levels, carbon dioxide levels, and hydrogen ion concentration (pH).
The carotid body contains specialized nerve endings called glomus cells that are sensitive to changes in these chemical parameters. When there is a decrease in oxygen or an increase in carbon dioxide or hydrogen ions, the glomus cells release neurotransmitters such as acetylcholine and dopamine, which activate afferent nerve fibers leading to the brainstem's nucleus tractus solitarius. This information is then integrated with other physiological signals in the brainstem, resulting in appropriate adjustments in breathing rate, depth, and pattern, as well as changes in heart rate and blood vessel diameter to maintain homeostasis.
Dysfunction of the carotid body can lead to various disorders, such as hypertension, sleep apnea, and chronic lung disease. In some cases, overactivity of the carotid body may result in conditions like primary breathing pattern disorders or pseudohypoxia, where the body responds as if it is experiencing hypoxia despite normal oxygen levels.
Tympanic nerve
Paraganglioma
List of MeSH codes (C04)
List of MeSH codes (A09)
List of MeSH codes (A08)
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Tumor13
- Glomus tympanicum (GT) is a highly vascular, benign, and slow-growing tumor of the middle ear. (otolaryngrhinojournal.com)
- CT scan showing: the presence of eroding jugular bulb is the most important thing to distinguish glomus tympanicum and glomus jugulare and assess the extension of the tumor to make good surgical planning. (otolaryngrhinojournal.com)
- A large retrospective, multicenter, international study analyzed the long-term outcome in 132 patients with primary radiation treatment or radiation after partial resection of a glomus tumor. (medscape.com)
- A German study of 32 patients who underwent stereotactic radiosurgery for glomus jugulare tumors showed that stereotactic linear accelerator (LINAC) radiosurgery achieved excellent long-term tumor control, along with a low rate of morbidity. (medscape.com)
- Glomus jugulare tumor. (naqlafshk.com)
- This is the most common type of glomus tumor of the head and neck. (naqlafshk.com)
- Glomus vagale tumor. (naqlafshk.com)
- Glomus jugulare tumor surgery. (lookfordiagnosis.com)
- Dr. Mark Levenson removes a glomus tympanicum tumor. (lookfordiagnosis.com)
- This is part to of us explaining our lives with a glomus jugular tumor. (lookfordiagnosis.com)
- In fact, if PT is the only symptom of a presumed glomus tumor, it should give rise to a though that perhaps it is not glomus after all. (neuroangio.org)
- Here is a typical glomus tumor in a patient presenting with facial nerve palsy and pulsatile tinnitus. (neuroangio.org)
- Glomus tympanicum tumors are a rare type of middle ear tumor that often present with symptoms such as pulsatile tinnitus, hearing loss, and ear fullness. (jcohns.org)
Diagnosis2
- A high-resolution temporal bone computed tomography (CT) scan demonstrating a contrast-enhancing mass limited to the middle ear at the level of the cochlear promontory with an intact plate of bone at the lateral aspect of the jugular fossa suggests the diagnosis of glomus tympanicum. (medscape.com)
- Diagnosis: glomus tympanicum type II. (otolaryngrhinojournal.com)
Paraganglioma3
- Glomus tumors, also known as non-chromaffin cell paraganglioma, arise from the neural crest cells [1]. (otolaryngrhinojournal.com)
- The tympanic nerve may be involved by paraganglioma, in this location referred to as a glomus tympanicum tumour. (wikipedia.org)
- Glomus tumors are part of "paraganglioma" family of tumors. (neuroangio.org)
Tumors are diagnosed1
- Often, glomus jugulare tumors are diagnosed within the sixth or seventh decade of life and can be followed by imaging only and may not need surgical intervention. (medscape.com)
Pulsatile tinnitus3
- Glomus tumors are rare, and the majority do not present with isolated pulsatile tinnitus. (neuroangio.org)
- Nevertheless, Glomus Jugulare and Glomus Tympanicum tumors are well-known to cause pulsatile tinnitus. (neuroangio.org)
- Rarely tumors may also present with a pulsatile tinnitus, including glomus tympanicum, glomus jugulare, or tumors next to the brain impacting the hearing nerves. (advancedhearingatlanta.com)
Excision3
- Huyen PX, Nhan HH, The PT, Hoa CC. Transcanal Endoscopic Excision of Glomus Tympanicum in can tho Ent Hospital: Three Cases Report. (otolaryngrhinojournal.com)
- From 2021 to 2022, there were three cases of glomus tympanicum tumors operated by trans-canal endoscopic excision in Can Tho ENT hospital. (otolaryngrhinojournal.com)
- New video: 'Endoscopic glomus tympanicum excision using Calvian endo-pen®' performed by Brandon Isaacson, M.D. (sutter-usa.com)
Carotid5
- Glomus tumors are classified into types depending on where they begin to grow: tympanicum, jugulare, glomus vagale, or carotid body. (otolaryngrhinojournal.com)
- About 80% of all glomus tumors are carotid body tumors or glomus jugulare tumors. (naqlafshk.com)
- Haller introduced glomus tumors of the head and neck into the medical record in 1762 when he described a mass at the carotid bifurcation that had a glomus body-like structure. (naqlafshk.com)
- Glomus tumors of the head and neck are associated with 4 primary locations, the jugular bulb, middle ear cavity, vagus nerve, and carotid body. (naqlafshk.com)
- Carotid body glomus tumors, also called carotid body tumors, occur at the bifurcation of the common carotid artery and arise from the tissue of the normal carotid body (see the image below). (naqlafshk.com)
Bulb2
- Glomus jugulare arise from paraganglia in or around the jugular bulb, and as they grow they occlude this venous structure. (earsite.com)
- Nonchromaffin paragangliomas (chemodectomas) arise in the temporal bone from glomus bodies in the jugular bulb (glomus jugulare tumors) or the medial wall of the middle ear (glomus tympanicum tumors). (msdmanuals.com)
Vagale1
- Tumors in region of the vagus nerve are commonly called glomus vagale tumors because of their usual close association with the vagus nerve (see the image below). (naqlafshk.com)
Temporal bone2
- Temporal bone CT has historically been even better than MRI for glomus, especially glomus tympanicum - an unusual situation since for most tumors MRI is a better test. (neuroangio.org)
- In other words, if you've had a negative temporal bone CT and negative MRI brain with contrast, the chances of having a glomus tympanicum or jugulare are pretty much zero. (neuroangio.org)
Paragangliomas2
- Imaging is the primary investigative modality for glomus tumors of the head and neck (paragangliomas). (naqlafshk.com)
- Paragangliomas, also known as glomus tumors, arise from paraganglion cells which form the basis of the extra-adrenal neuroendocrine system. (springeropen.com)
Arise1
- they arise from the glomus bodies that run with the tympanic branch of the glossopharyngeal nerve. (naqlafshk.com)
Resection2
- The mainstay of glomus treatment used to be surgical resection. (neuroangio.org)
- En bloc resection of the ear canal with sparing of the facial nerve is done when lesions are limited to the canal and have not invaded the middle ear. (msdmanuals.com)
Jugular foramen2
- Glomus jugulare ones grow in the jugular foramen, and therefore present with symptoms related to destruction/invasion of adjacent structures. (neuroangio.org)
- Cranial nerve palsies of the 9th, 10th, or 11th nerve may accompany glomus jugulare tumors that extend through the jugular foramen. (msdmanuals.com)
Approach1
- A study from Vanderbilt University found that in the absence of brainstem compression or concern for malignancy, observation of glomus jugulare tumors can be a viable initial management approach for elderly patients. (medscape.com)
Small2
- Glomus tympanicum tumors are small sized tumors originating in the middle ear. (earsite.com)
- Standard MRI with contrast and MRA are very good for picking up these tumors, except perhaps a small glomus tympanicum. (neuroangio.org)
Surgery2
- Surgery is the treatment of choice for glomus jugulare tumors. (medscape.com)
- Of 22 patients with glomus jugulare tumors who underwent Gamma Knife surgery, neurologic status improved in 12 patients, 7 showed stable clinical condition, and 3 patients developed new moderate deficits. (medscape.com)
Symptoms1
- If it is in fact a glomus, usually other symptoms are present as well. (neuroangio.org)
Head1
- Although glomus tympanicum tumors are the most common primary neoplasms of the middle ear, these tumors are the rarest of head and neck glomus tumors. (naqlafshk.com)
Tumors20
- Ibrahim R, Ammori MB, Yianni J, Grainger A, Rowe J, Radatz M. Gamma Knife radiosurgery for glomus jugulare tumors: a single-center series of 75 cases. (medscape.com)
- Microsurgical resection of glomus jugulare tumors with facial nerve reconstruction: 3-dimensional operative video. (medscape.com)
- Okada O, Demitsu T, Manabe M, Yoneda K. A case of multiple subungual glomus tumors associated with neurofibromatosis type 1. (medscape.com)
- Semaan MT, Megerian CA. Current assessment and management of glomus tumors. (medscape.com)
- Gamma knife radiosurgery for glomus jugulare tumors: Therapeutic advantages of minimalism in the skull base. (medscape.com)
- Image-guided robotic radiosurgery for glomus jugulare tumors - multicenter experience and review of the literature. (medscape.com)
- Long-term outcomes after radiosurgery for glomus jugulare tumors. (medscape.com)
- Stereotactic Radiosurgical Treatment of Glomus Jugulare Tumors. (medscape.com)
- Dobberpuhl MR, Maxwell S, Feddock J, St Clair W, Bush ML. Treatment Outcomes for Single Modality Management of Glomus Jugulare Tumors With Stereotactic Radiosurgery. (medscape.com)
- Clinical characteristics and surgical strategy of glomus tympanicum tumors. (bvsalud.org)
- Nonchromaffin paragangliomas (chemodectomas) arise in the temporal bone from glomus bodies in the jugular bulb (glomus jugulare tumors) or the medial wall of the middle ear (glomus tympanicum tumors). (msdmanuals.com)
- Cranial nerve palsies of the 9th, 10th, or 11th nerve may accompany glomus jugulare tumors that extend through the jugular foramen. (msdmanuals.com)
- Glomus tumors arise from tissue that senses gases in the blood and are virtually always benign, non-cancerous. (tampabayhearing.com)
- The more limited form of glomus tumors arise in the middle ear and are called glomus tympanicum. (tampabayhearing.com)
- The more extensive forms of glomus tumors involve the jugular bulb, the nerves of swallowing, voice box functioning, facial movement, tongue movement, and shoulder elevation. (tampabayhearing.com)
- Management of glomus jugulare tumors is usually by surgery, but radiation may sometimes be employed. (tampabayhearing.com)
- Glomus tumors rarely secrete hormones which cause high blood pressure and may cause a severe form of rapid heart beat that can be fatal. (tampabayhearing.com)
- Management of glomus tumors may require highly a specialized radiology procedure called embolization. (tampabayhearing.com)
- Pham V, Young D, Quinn FB, Quinn MS. Glomus tumors of the temporal bone: synopsis of glomus tympanicum and jugulare. (ijorl.com)
- More pronounced deficits that put the patient will continue to occur during middle ear mastoiditis) causes, or tumors (glomus tympanicum or jugulo tympanicum and meningioma). (cide.edu)
Middle ear4
- A high-resolution temporal bone computed tomography (CT) scan demonstrating a contrast-enhancing mass limited to the middle ear at the level of the cochlear promontory with an intact plate of bone at the lateral aspect of the jugular fossa suggests the diagnosis of glomus tympanicum. (medscape.com)
- 5. [The condition of the middle ear mucosa in chemodectoma of the tympanic glomus at the early stage of the disease]. (nih.gov)
- En bloc resection of the ear canal with sparing of the facial nerve is done when lesions are limited to the canal and have not invaded the middle ear. (msdmanuals.com)
- Middle ear masses include congenital cholesteatoma , glomus tympanicum, or middle ear adenoma, for example. (medscape.com)
Jugular2
- These glomus bodies are most commonly found in the jugular bulb, the top of the internal jugular vein, before it exits the skull base. (tampabayhearing.com)
- In general, most HNPGLs (carotid body, glomus jugulotympanicum, vagal, and jugular paragangliomas) are nonsecretory and may be treated with active observation, surgical resection, or radiation therapy. (nih.gov)
Mass1
- strong>A differential of glomus tympanicum must be considered in cases which present with bleeding left external auditory canal mass and otalgia, although the most common presentations are hearing loss and tinnitus. (peertechzpublications.com)