Bowman Capsule: A double-walled epithelial capsule that is the bulbous closed proximal end of the kidney tubular system. It surrounds the cluster of convoluted capillaries of KIDNEY GLOMERULUS and is continuous with the convoluted PROXIMAL KIDNEY TUBULE.WT1 Proteins: Isoforms encoded by the WT1 Wilms tumor suppressor gene (GENES, WILMS TUMOR) and produced by alternative splicings. They are zinc finger-containing transcription factors involved in both transactivation and repression, and are critical for normal development and function of the urogenital tract.Podocytes: Highly differentiated epithelial cells of the visceral layer of BOWMAN CAPSULE of the KIDNEY. They are composed of a cell body with major CELL SURFACE EXTENSIONS and secondary fingerlike extensions called pedicels. They enwrap the KIDNEY GLOMERULUS capillaries with their cell surface extensions forming a filtration structure. The pedicels of neighboring podocytes interdigitate with each other leaving between them filtration slits that are bridged by an extracellular structure impermeable to large macromolecules called the slit diaphragm, and provide the last barrier to protein loss in the KIDNEY.Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.Glomerulosclerosis, Focal Segmental: A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.Bone Marrow Neoplasms: Neoplasms located in the bone marrow. They are differentiated from neoplasms composed of bone marrow cells, such as MULTIPLE MYELOMA. Most bone marrow neoplasms are metastatic.Kidney Glomerulus: A cluster of convoluted capillaries beginning at each nephric tubule in the kidney and held together by connective tissue.Proteoglycans: Glycoproteins which have a very high polysaccharide content.Epithelium: One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.Epithelial Cells: Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.Chondroitin Sulfate Proteoglycans: Proteoglycans consisting of proteins linked to one or more CHONDROITIN SULFATE-containing oligosaccharide chains.Dermatan Sulfate: A naturally occurring glycosaminoglycan found mostly in the skin and in connective tissue. It differs from CHONDROITIN SULFATE A (see CHONDROITIN SULFATES) by containing IDURONIC ACID in place of glucuronic acid, its epimer, at carbon atom 5. (from Merck, 12th ed)Glycosaminoglycans: Heteropolysaccharides which contain an N-acetylated hexosamine in a characteristic repeating disaccharide unit. The repeating structure of each disaccharide involves alternate 1,4- and 1,3-linkages consisting of either N-acetylglucosamine or N-acetylgalactosamine.Paramphistomatidae: A family of flukes of the class Trematoda found in the intestinal tract and liver of animals and man. Some of the genera are Homalagaster, Gastrodiscus, Paramphistomum, Watsonius, Nilocotyle, Gigantocotyle, Gastrothylax, Macropotrema, Ceylonocotyle, Zygocotyle, Cotylophoron, and Calicophoron.Fasciolidae: A family of flukes of the class Trematoda occurring primarily in the liver of animals and man. There are six genera: Fasciola, Fasciolopsis, Fascioloides, Tenuifasciola, Parafasciolopsis, and Protofasciola. The adult form of Fasciolopsis occurs in the intestines of pigs and man.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Research Personnel: Those individuals engaged in research.Research Support as Topic: Financial support of research activities.Catechin: An antioxidant flavonoid, occurring especially in woody plants as both (+)-catechin and (-)-epicatechin (cis) forms.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Propyl Gallate: Antioxidant for foods, fats, oils, ethers, emulsions, waxes, and transformer oils.16,16-Dimethylprostaglandin E2: A synthetic prostaglandin E analog that protects the gastric mucosa, prevents ulceration, and promotes the healing of peptic ulcers. The protective effect is independent of acid inhibition. It is also a potent inhibitor of pancreatic function and growth of experimental tumors.Epirizole: 4-Methoxy-2-(5-methoxy-3-methylpyrazol-1-yl)-6-methylpyrimidine. A pyrimidinyl pyrazole with antipyretic, analgesic, and anti-inflammatory activity.Prostaglandins E, Synthetic: Analogs or derivatives of prostaglandins E that do not occur naturally in the body. They do not include the product of the chemical synthesis of hormonal PGE.Antigens, CD55: GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.Complement Activation: The sequential activation of serum COMPLEMENT PROTEINS to create the COMPLEMENT MEMBRANE ATTACK COMPLEX. Factors initiating complement activation include ANTIGEN-ANTIBODY COMPLEXES, microbial ANTIGENS, or cell surface POLYSACCHARIDES.Capillaries: The minute vessels that connect the arterioles and venules.Phosphoinositide Phospholipase C: A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under this classification are involved in intracellular signaling.Complement Membrane Attack Complex: A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC.Research Support, U.S. Gov't, Non-P.H.S.Research Support, U.S. Gov't, P.H.S.Research Support, Non-U.S. Gov'tResearch Support, U.S. GovernmentResearch Support, American Recovery and Reinvestment ActResearch Support, N.I.H., ExtramuralResearch Support, N.I.H., IntramuralTexasEpithelial-Mesenchymal Transition: Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.Clinical Trials, Phase I as Topic: Works about studies performed to evaluate the safety of diagnostic, therapeutic, or prophylactic drugs, devices, or techniques in healthy subjects and to determine the safe dosage range (if appropriate). These tests also are used to determine pharmacologic and pharmacokinetic properties (toxicity, metabolism, absorption, elimination, and preferred route of administration). They involve a small number of persons and usually last about 1 year. This concept includes phase I studies conducted both in the U.S. and in other countries.Mice, Transgenic: Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.Mice, Inbred C57BLDiabetic Nephropathies: KIDNEY injuries associated with diabetes mellitus and affecting KIDNEY GLOMERULUS; ARTERIOLES; KIDNEY TUBULES; and the interstitium. Clinical signs include persistent PROTEINURIA, from microalbuminuria progressing to ALBUMINURIA of greater than 300 mg/24 h, leading to reduced GLOMERULAR FILTRATION RATE and END-STAGE RENAL DISEASE.Mice, Knockout: Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.Basement Membrane: A darkly stained mat-like EXTRACELLULAR MATRIX (ECM) that separates cell layers, such as EPITHELIUM from ENDOTHELIUM or a layer of CONNECTIVE TISSUE. The ECM layer that supports an overlying EPITHELIUM or ENDOTHELIUM is called basal lamina. Basement membrane (BM) can be formed by the fusion of either two adjacent basal laminae or a basal lamina with an adjacent reticular lamina of connective tissue. BM, composed mainly of TYPE IV COLLAGEN; glycoprotein LAMININ; and PROTEOGLYCAN, provides barriers as well as channels between interacting cell layers.Glomerular Basement Membrane: The layer of EXTRACELLULAR MATRIX that lies between the ENDOTHELIUM of the glomerular capillaries and the PODOCYTES of the inner or visceral layer of the BOWMAN CAPSULE. It is the product of these two cell types. It acts as a physical barrier and an ion-selective filter.Glomerular Filtration Barrier: A specialized barrier in the kidney, consisting of the fenestrated CAPILLARY ENDOTHELIUM; GLOMERULAR BASEMENT MEMBRANE; and glomerular epithelium (PODOCYTES). The barrier prevents the filtration of PLASMA PROTEINS.Laminin: Large, noncollagenous glycoprotein with antigenic properties. It is localized in the basement membrane lamina lucida and functions to bind epithelial cells to the basement membrane. Evidence suggests that the protein plays a role in tumor invasion.Kidney: Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.Glomerular Filtration Rate: The volume of water filtered out of plasma through glomerular capillary walls into Bowman's capsules per unit of time. It is considered to be equivalent to INULIN clearance.Biological Science Disciplines: All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.Audiovisual Aids: Auditory and visual instructional materials.Computer-Assisted Instruction: A self-learning technique, usually online, involving interaction of the student with programmed instructional materials.Hemodynamics: The movement and the forces involved in the movement of the blood through the CARDIOVASCULAR SYSTEM.Teaching: The educational process of instructing.
2007). "Reduced glomerular epithelial protein 1 expression and podocyte injury in immunoglobulin A nephropathy". J. Int. Med. ... a renal glomerular epithelial cell (podocyte) membrane protein-tyrosine phosphatase. Identification, molecular cloning, and ...
The other area of interest is focused on the podocyte, or glomerular epithelial cell. The current research is focused on three ... She also identified several glomerular components that play a role in glomerular functions. In 1990, Farquhar and Palade ... The glomerular basement membrane: not gone, just forgotten. J. Clin. Invest. 116:2090-2093. Zhang YW, Luo WJ, Wang H, Lin P, ... The long-term goal for these three projects is to define the molecular mechanisms of glomerular filtration and protein ...
... are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular ... Takeda T, McQuistan T, Orlando RA, Farquhar MG (Jul 2001). "Loss of glomerular foot processes is associated with uncoupling of ... Takeda T, McQuistan T, Orlando RA, Farquhar MG (Jul 2001). "Loss of glomerular foot processes is associated with uncoupling of ... The encoded protein was originally identified as an important component of glomerular podocytes. Inactivation of the encoding ...
Likewise, the estimated glomerular filtration rate (eGFR) may progressively fall from a normal of over 90 ml/min/1.73m2 to less ... and the epithelial podocytes. The GFB is responsible for the highly selective filtration of blood entering the kidney's ... The value of the serum creatinine can be used to calculate the estimated glomerular filtration rate (eGFR), which reflects the ... This matrix invades the glomerular capillaries and produces deposits called Kimmelstiel-Wilson nodules. The mesangial cells and ...
Gerke P, Huber TB, Sellin L, Benzing T, Walz G (Apr 2003). "Homodimerization and heterodimerization of the glomerular podocyte ... and the podocytes of epithelial cells. Nephrin is a transmembrane protein that is a structural component of the slit diaphragm ... The renal filtration barrier consists of fenestrated endothelial cells, the glomerular basement membrane, ... "Nephrin is specifically located at the slit diaphragm of glomerular podocytes". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 7962-7. ...
Because the transcript they found was highly expressed in visceral glomerular epithelial cells (podocytes), TCF21 was ... and both mesenchymal and glomerular epithelial cells in the kidney. TCF21 is essential for regulating properties of the ... a mesoderm-specific basic-helix-loop-helix protein expressed in mesenchymal and glomerular epithelial cells in the developing ... TCF21 mRNA expression is very low in breast cancer cells compared with normal breast epithelial cells. This low expression is ...
... of collapsing glomerulopathy is collapse of glomerular tuft and proliferation and hyperplasia of glomerular visceral epithelial ...
This movement mainly occurs when an injury, or cell death occurs in the podocyte epithelial cells. When there is glomerular ... Specifically, it is a part of the glomerular filter, which separates blood from urine. The slit daiphragm is very thin ... Apoptosis leads to a decrease in podocyte epithelial cells which causes proteinuria and could culminate in glomerulosclerosis. ... is usually expressed during the early capillary loop stage of glomerulongenesis and creates a linear pattern on the epithelial ...
... on the glomerular epithelial cells. This, in turn, stimulates release of proteases and oxidants by the mesangial and epithelial ... The immune complexes are formed by binding of antibodies to antigens in the glomerular basement membrane. The antigens may be ... On electron microscopy, subepithelial deposits that nestle against the glomerular basement membrane seems to be the cause of ... The defining point of MGN is the presence of subepithelial immunoglobulin-containing deposits along the glomerular basement ...
... of the epithelial migrating precursors give rise to olfactory ensheathing glia that inhabit the olfactory nerve and glomerular ... axons invade the basal lamina of the glia limitans and the olfactory bulb to create the olfactory nerve and glomerular layers. ...
"Synthesis of Anticoagulantly Active Heparan Sulfate Proteoglycans by Glomerular Epithelial Cells Involves Multiple 3-O- ...
In due course, glomerular injury gives rise to scarring (glomerulosclerosis). Most of these patients have hematuria with ... producing in some cases epithelial crescents that fill Bowman's space. When extensive, immune complexes create an overall ...
Epithelial cells of the renal tubules, including all the segments of the nephron and the collecting ducts (with the exception ... Besides TKV and HtTKV, the estimated glomerular filtration rate (eGFR) has also been tentatively used to predict the ... Epithelial cell proliferation and fluid secretion that lead to cystogenesis are two hallmark features in ADPKD. During the ... glomerular filtration rate (GFR) remains normal for decades before kidney function starts to progressively deteriorate, making ...
Protein tyrosine phosphatase receptor type O, also known as glomerular epithelial protein 1 (GLEPP1), has been shown to be ... These are diffuse loss of visceral epithelial cells' foot processes (i.e., podocyte effacement), vacuolation, and growth of ... thereby increasing the glomerular permeability to serum albumin through a reduction of electrostatic repulsion. The loss of ... response with abnormal secretion of lymphokines by T cells is thought to reduce the production of anions in the glomerular ...
Her current work in inflammation and cancer focuses on trafficking in epithelial cells and on cytokine secretion in macrophages ... Stow, Farquhar and colleagues published seminal studies on glomerular basement membranes and proteoglycans. Upon leaving Yale, ... Stow and colleagues published important findings on secretion in polarized epithelial cells and published the first evidence ... US 1987 Discovered mechanism for pH dependent sorting in epithelial cells 1988 Appointment at Harvard University/Massachusetts ...
ATPase in the basolateral membrane of the epithelial cells. Thus, the glomerular filtrate becomes more concentrated, which is ... in that the osmotic potential of the fluid leaving the proximal convoluted tubule is the same as that of the initial glomerular ...
Sodium and glucose are co-transported by the SGLT-2 protein into the tubular epithelial cells across the brush-border membrane ... By inhibiting SGLT-2, medications of the gliflozin class prevent the kidneys' reuptake of glucose from the glomerular filtrate ... SGLT-2 is primarily expressed in the kidney on the epithelial cells lining the first segment of the proximal convoluted tubule ... It is the major transport protein that promotes reabsorption from the glomerular filtration glucose back into circulation and ...
Glomerular flow is decreased if the chloride concentration is above the target value. Constricting the smooth muscle cells in ... The macula densa is a collection of densely packed epithelial cells at the junction of the thick ascending limb (TAL) and ... A high protein diet affects the feedback activity by making the single nephron glomerular filtration rate higher, and the Na ... The critical target of the trans-JGA signaling cascade is the glomerular afferent arteriole; its response consists of an ...
This may have been related to the swelling of the glomerular basement membranes and the progressive fusion of epithelial cell ... renal vessels time to recover their tone sufficiently to prevent full systolic pressure being applied to the fragile glomerular ... and histology of the survivors from the original experiment showed glomerular hypercellularity which he attributed to a ... dog kidneys for 24 hours with specifically sensitised cryoprecipitated dog plasma and found that he could induce glomerular and ...
... has an important role in the maintenance of the glomerular filtration barrier. Decreased perlecan in the glomerular ... When T84 intestinal epithelial cells are exposed to hypoxic conditions for 24 hours a significant increase in perlecan mRNA and ... Olfactory neurite outgrowth in mouse development is guided at least in part by an ECM laid down by olfactory epithelial cells ( ... By contrast, tumor formation of the immortalized mouse epithelial cell line RT101 injected into rats was dependent on perlecan ...
These thin epithelial tubes are densely packed with cilia and have a distinct morpology to the other tubular epithelia of the ... The glomerular filtrate flows directly into the coelom, or a dorsal compartment of the coelom known as the nephrocoel. In ... One unique feature of pronephroi is the arrangement by which the glomerular filtrate is generated and collected by the nephron ...
Reabsorbsion of molecules and ions back into the blood from the proximal tube is done via epithelial cells. The epithelial cell ... The glomerular filtration rate of single nephrons in birds is low because avian glomeruli have small surface area. Through the ... Glomerular filtration only accounts for 10% to 20% of urinary urate. Greater than 90% of urate excreted by the kidneys is ... The osmotic gradient allows for the cotransport of Na+ with molecules such as Cl-, glucose, and vitamins into the epithelial ...
Proximal tubular epithelial cells (PTECs) have a pivotal role in kidney disease. Two mammalian cell lines are commonly used as ... occurs when the PTECs are unable to properly reabsorb glomerular filtrate so that there is increased loss of bicarbonate, ... The luminal surface of the epithelial cells of this segment of the nephron is covered with densely packed microvilli forming a ... Cuboidal epithelial cells lining the proximal tubule have extensive lateral interdigitations between neighboring cells, which ...
The most notable examples of basement membranes is the glomerular basement membrane of the kidney, by the fusion of the basal ... Early stages of malignancy that are thus limited to the epithelial layer by the basement membrane are called carcinoma in situ ... To represent the above in a visually organised manner, the basement membrane is organized as follows: Epithelial/mesothelial/ ... lamina from the endothelium of glomerular capillaries and the podocyte basal lamina, and between lung alveoli and pulmonary ...
Finally, epithelial cells of sweat gland ducts and distal colon surface respond exactly the same as the principal cells of the ... The increased blood pressure will lead to increased glomerular filtration rate and cause a decrease in renin release from the ... In the principal cells aldosterone increases activity of basolateral membrane sodium-potassium ATPase and apical epithelial ...
Epithelial sodium channel blockers: amiloride and triamterene.. Calcium-sparing diureticsEdit. The term "calcium-sparing ... Inhibits reabsorption of Na+, increase glomerular filtration rate 1. tubules Chemically, diuretics are a diverse group of ... Inhibition of Na+/K+ exchanger: Spironolactone inhibits aldosterone action, Amiloride inhibits epithelial sodium channels[17]. ... Osmotic diuretics (e.g. mannitol) are substances that increase osmolarity but have limited tubular epithelial cell permeability ...
Integrin matrix receptors on glomerular epithelial cells (GEC) may play an important role in adhesion of GEC to the glomerular ... Characterization of glomerular epithelial cell matrix receptors.. Adler S1.. Author information. 1. Department of Medicine, New ... Glomerular epithelial cell adhesion to types I and IV collagen was slightly greater than to laminin and fibronectin. Adhesion ... Beta 1 integrin matrix receptors were detected on all three glomerular cell types in rat kidney in vivo and at areas of cell- ...
Marian Miller (2015) CIL:48058, Macaca mulatta, kidney glomerular epithelial cell. CIL. Dataset. https://doi.org/doi:10.7295/ ...
Cells of renin lineage residing alongside glomerular capillaries are reported to … ... a process directly underlying progressive glomerular scarring and decline of kidney function. The inherent repair process is ... of renin lineage may enhance glomerular regeneration by serving as progenitors for glomerular epithelial cells in glomerular ... Cells of Renin Lineage Are Progenitors of Podocytes and Parietal Epithelial Cells in Experimental Glomerular Disease Am J ...
... a useful pharmacologic approach to decipher the mechanisms underlying the possible progenitor role of parietal epithelial cells ... ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases. Thus, ATRA ... Conclusion: ATRA increases the number of glomerular epithelial transition cells in experimental proteinuric glomerular diseases ... Retinoids Augment the Expression of Podocyte Proteins by Glomerular Parietal Epithelial Cells in Experimental Glomerular ...
Glomerular epithelial protein.. Glomerular epithelial protein (GLEPP1) is a membrane-bound protein-tyrosine phosphatase present ... PAX-2 plays a crucial role in early glomerular development, when most of the cell proliferation of glomerular epithelial cells ... However, an excretion of glomerular epithelial cells might indicate destructive glomerular disease; therefore, it could be ... Glomerular epithelial cells in the urine: what has to be done to make them worthwhile?. Andrej Skoberne, Andrzej Konieczny, ...
Because glomerular-basement-membrane HSPG is thought to be derived from mesangial cells and glomerular visceral epithelial ... Proteoglycan production by human glomerular visceral epithelial cells and mesangial cells in vitro. N F van Det, J van den Born ... Culture medium of glomerular visceral epithelial cells contained HSPG and a second proteoglycan with the properties of a hybrid ... Glomerular visceral epithelial cells produced significantly higher levels of HS (between 197.56 and 269.40 micrograms/72 h per ...
Cultured glomerular epithelial cell. Research Abstract. Cultured glomerular epithelial cells in the loboratory of Dr. Salant in ... Visceral epithelial cells in rat glomerular cell culture European Journal of Cell Biology. 67. 131-144 (1995). *. Description ... Visceral epithelial cells in rat glomerular cell culture European Journal of Cell Biology. 67. 131-144 (1995). *. Description ... Publications] D.J.Salant,Y.Natori,F.Shimizu (cd.by E.G.Neilson,W.G.Couser): Immunologic Renal Diseases Glomerular injury due ...
co-wlture / glomerular epithelial cells / mesangial cells / IU-beta / 糸球体再構築モデル / 透過性コラーゲン膜. ... To clarify the interaction between glomerular epithelial cells and mesangial cells, we examined ^3H-thymidine incorporation of ... These results indicate that glomerular epithelial cells regulate mesangial proliferation under both physiological and ... Analysis of interaction between glomerular epithelial cells and mesangial cells. Research Project ...
Pathologic glomerular epithelial cell (GEC) hyperplasia is characteristic of both rapidly progressive glomerulonephritis (RPGN ... Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. ... Krüppel-like factor 4 is a negative regulator of STAT3-induced glomerular epithelial cell proliferation. ... This triggered IL-6 release into the supernatant, which activated STAT3 signaling in parietal epithelial cells. Conversely, ...
glomerular visceral epithelial cell development glomerular visceral epithelial cell fate commitment glomerular visceral ... glomerular epithelial cell differentiation renal filtration cell differentiation glomerular epithelial cell differentiation ... mesonephric glomerular visceral epithelial cell differentiation metanephric glomerular visceral epithelial cell differentiation ... mesonephric glomerular visceral epithelial cell differentiation metanephric glomerular visceral epithelial cell differentiation ...
Inimeste Glomerular epiteeli rakkude, HGEC tähistab Inimeste Glomerular epiteeli rakkude ... Avaleht › 4 tähte › HGEC › Inimeste Glomerular epiteeli rakkude. HGEC: Inimeste Glomerular epiteeli rakkude Mida tähendab HGEC ...
This study was designed to investigate whether EGCG plays a cytoprotective role in glomerular epithelial cells (GECs) under ... This study was designed to investigate whether EGCG plays a cytoprotective role in glomerular epithelial cells (GECs) under ... Effects of epigallocatechin-3-gallate on high glucose-induced glomerular epithelial cell damage ... Effects of epigallocatechin-3-gallate on high glucose-induced glomerular epithelial cell damage , 2005 Year , 박성준(전남대학교). ) ...
regulation of metanephric glomerular visceral epithelial cell development - Ontology Report - Chinchilla Research Resource ... metanephric glomerular visceral epithelial cell development. 3. regulation of metanephric glomerular visceral epithelial cell ... regulation of metanephric glomerular visceral epithelial cell development. 1. positive regulation of metanephric glomerular ... regulation of metanephric glomerular visceral epithelial cell development. go back to main search page ...
title = "Decay accelerating factor regulates complement activation on glomerular epithelial cells",. abstract = "Epithelial ... N2 - Epithelial cells of the glomerular capillary are the site of C5b-9 mediated injury in rat membranous nephropathy. We ... AB - Epithelial cells of the glomerular capillary are the site of C5b-9 mediated injury in rat membranous nephropathy. We ... Epithelial cells of the glomerular capillary are the site of C5b-9 mediated injury in rat membranous nephropathy. We ...
... glomerular basement membrane; GHR, growth hormone receptor; GLEPP1, glomerular epithelial (podocyte) protein 1; IGFR, insulin ... a) A glomerulus contains a capillary tuft that receives primary structural support from the glomerular basement membrane (GBM ... Glomerular endothelial cells (E) lining the capillary lumen (CL) and mesangial cells (M) are located on the blood side of the ... it receives and transmits chemical and mechanical signals to/from the glomerular basement membrane upon which it elaborates, ...
Podocytes are terminally differentiated glomerular epithelial cells. do, however, reduce manifestation. Podocytes are ... terminally differentiated glomerular epithelial cells. do, however, reduce manifestation of WT1, a transcription element, and ... The cumulative result is a predominant nuclear localisation of endogenous BAG-1 protein in colorectal epithelial cells ( ...
Podocytes are terminally differentiated glomerular epithelial cells. do, however, reduce manifestation. Podocytes are ... terminally differentiated glomerular epithelial cells. do, however, reduce manifestation of WT1, a transcription element, and ...
Researches also reported that TWEAK/Fn14 induced apoptosis of glomerular mesangial cells and tubular epithelial cells with ... including Glomerular Activity Index (GAI) (. 𝑟. G. A. I. =. 0. .. 7. 4. 5. , 𝑟. T. I. A. I. =. 0. .. 7. 5. 1. ) and those with ... Glomerular Activity Index (GAI) (. 𝑟. =. 0. .. 7. 4. 5. , 𝑃. ,. 0. .. 0. 1. ), and Tubulointerstitial Activity Index (TIAI) (. ... glomerular activity index (. 𝑟. =. 0. .. 7. 5. 4. , 𝑃. ,. 0. .. 0. 1. ), and tubulointerstitial qualitative activity index (. 𝑟 ...
BTBR ob/ob mice exhibited enlarged glomerular tuft area and expansion of the glomerular mesangial matrix (Figure 13, D-H). BTBR ... Glomerular profiles that were closer than one glomerular diameter to the edge of the sections were excluded from the study. All ... PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. Yajuan Li,1 Qingsong Hu,1 Chunlai Li,1,2 ... Anti-inflammatory effects of triptolide in human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000;279(5): ...
Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial ... Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial ... Ribosomal biogenesis induction by high glucose requires activation of upstream binding factor in kidney glomerular epithelial ... and rDNA transcription in glomerular epithelial cells (GECs) compared with 5 mM glucose. High glucose induced Ser388 ...
Glomerular Epithelial and Mesangial Cell Culture and Characterization Heather M. Wilson, Keith N. Stewart ... Well-Differentiated Human Airway Epithelial Cell Cultures M. Leslie Fulcher, Sherif Gabriel, Kimberlie A. Burns, James R. ... New to this edition are chapters on fibroblasts, Schwann cells, gastric and colonic epithelial cells, and parathyroid cells. ... Isolation and Culture of Human Colon Epithelial Cells Using a Modified Explant Technique Employing a Noninjurious Approach ...
Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes ... glomerular visceral epithelial cell development Source: UniProtKBInferred from mutant phenotypei*19005011 ... glomerular basement membrane development Source: UniProtKB ,p>Inferred from Mutant Phenotype,/p> ,p>Describes annotations that ... Required for normal morphology of the glomerular basement membrane, normal development of foot processes by kidney podocytes ...
Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and ... glomerular visceral epithelial cell differentiation Source: UniProtKBInferred from mutant phenotypei*11086029 ... Mutant animals have a reduced glomerular filtration rate and reduced glomerular nephrin (NPHS1) content. However, there is no ... negative regulation of glomerular filtration Source: UniProtKB. *peptidyl-tyrosine dephosphorylation Source: UniProtKBInferred ...
ENaC indicates epithelial sodium channel; GFR, glomerular filtration rate; NOS1, neuronal nitric oxide synthase; NOS3, ... Regulation of the epithelial Na+ channel by endothelin-1 in rat collecting duct. Am J Physiol Renal Physiol. 2008;295:F1063- ... Endothelin-1 increases glomerular permeability and inflammation independent of blood pressure in the rat. Hypertension. 2010;56 ... The fundamental mechanism for ET-1 participation in hypertension seems to be a loss of epithelial ETB receptor function in the ...
... one synthesized by the glomerular epithelial cell (podocyte) and the other by the glomerular endothelial cell. The main ... The glomerular basement membrane (GBM) is a crucial component of the kidneys filtration barrier that separates the vasculature ... In contrast, mutations that affect GBM collagen IV or agrin do not impair glomerular development or cause immediate leakage of ... Glomerular Basement Membrane Heparan Sulfate Proteoglycans Humans Kidney Glomerulus Laminin Organogenesis Permeability ...
  • During development, the EMT process essentially works in reverse: you start with mesenchymal cells, and via cross-talk between the metanephric mesenchyme and the ureteric bud there is a gradual commitment of cells to an epithelial morphology. (blogspot.com)
  • With this knowledge comes the promise of better therapies in the future, directed toward halting pathways of injury and fibrosis, or interrupting the underlying pathophysiology of the individual diseases that lead to significant and progressive glomerular disease. (asnjournals.org)
  • Smoyer, William 2017-07-22 00:00:00 Albuminuria is both a characteristic hallmark and a known risk factor for progressive glomerular disease. (deepdyve.com)
  • Reduced local production of glomerular Vegfa in a mouse model of type 1 diabetes promotes endothelial injury accelerating the progression of glomerular injury. (diabetesjournals.org)
  • Although the molecular basis for a potential causative role for albuminuria in progressive chronic kidney disease remains poorly understood, there have been several recent advances in our understanding of the role of albumin, and its molecular modifications, in the development and progression of glomerular disease. (deepdyve.com)
  • A case of primary glomerular fibrosis associated with the accumulation of type I and type III collagen. (nii.ac.jp)
  • The purpose of this study is to determine if an investigational cell therapy called Cvac can help epithelial ovarian cancer (EOC) from returning when administered to patients who are in complete remission after surgical removal of their tumor followed by standard first-line (Part A) or second-line (Part B) chemotherapy. (clinicaltrials.gov)
  • Glomerular epithelial cell adhesion to types I and IV collagen was slightly greater than to laminin and fibronectin. (nih.gov)
  • Cadherins are a large family of transmembrane glycoproteins, that mediate calcium-dependent cell-cell adhesion in normal epithelial cells and play essential role in development, establishment and maintenance of cell polarity and tissue architecture. (uninet.edu)
  • Comments on A. Margulis and colleagues' article about the association of the loss of E-cadherin function with the disruption of cell-cell adhesion and invasion of epithelial cells into the connective tissue stroma of the dermis. (ebscohost.com)
  • We therefore examined the effect of juvenile obesity induced by exposure to a restricted activity environment from weaning until early adulthood on the molecular responses within the kidney together with glomerular area and nucleated cell number. (ahajournals.org)
more