Trimethylsilyl Compounds: Organic silicon derivatives used to characterize hydroxysteroids, nucleosides, and related compounds. Trimethylsilyl esters of amino acids are used in peptide synthesis.Azides: Organic or inorganic compounds that contain the -N3 group.Sodium Azide: A cytochrome oxidase inhibitor which is a nitridizing agent and an inhibitor of terminal oxidation. (From Merck Index, 12th ed)Gas Chromatography-Mass Spectrometry: A microanalytical technique combining mass spectrometry and gas chromatography for the qualitative as well as quantitative determinations of compounds.Chromatography, Gas: Fractionation of a vaporized sample as a consequence of partition between a mobile gaseous phase and a stationary phase held in a column. Two types are gas-solid chromatography, where the fixed phase is a solid, and gas-liquid, in which the stationary phase is a nonvolatile liquid supported on an inert solid matrix.AcetalsSilanes: Compounds similar to hydrocarbons in which a tetravalent silicon atom replaces the carbon atom. They are very reactive, ignite in air, and form useful derivatives.Hydrocarbons, IodinatedCarboxylic Acids: Organic compounds containing the carboxy group (-COOH). This group of compounds includes amino acids and fatty acids. Carboxylic acids can be saturated, unsaturated, or aromatic.Stereoisomerism: The phenomenon whereby compounds whose molecules have the same number and kind of atoms and the same atomic arrangement, but differ in their spatial relationships. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)KetonesCyclization: Changing an open-chain hydrocarbon to a closed ring. (McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Cerebrosides: Neutral glycosphingolipids that contain a monosaccharide, normally glucose or galactose, in 1-ortho-beta-glycosidic linkage with the primary alcohol of an N-acyl sphingoid (ceramide). In plants the monosaccharide is normally glucose and the sphingoid usually phytosphingosine. In animals, the monosaccharide is usually galactose, though this may vary with the tissue and the sphingoid is usually sphingosine or dihydrosphingosine. (From Oxford Dictionary of Biochemistry and Molecular Biology, 1st ed)Cells, Immobilized: Microbial, plant, or animal cells which are immobilized by attachment to solid structures, usually a column matrix. A common use of immobilized cells is in biotechnology for the bioconversion of a substrate to a particular product. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Silicon: A trace element that constitutes about 27.6% of the earth's crust in the form of SILICON DIOXIDE. It does not occur free in nature. Silicon has the atomic symbol Si, atomic number 14, and atomic weight [28.084; 28.086].Mass Spectrometry: An analytical method used in determining the identity of a chemical based on its mass using mass analyzers/mass spectrometers.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Psidium: A plant genus of the family MYRTACEAE that bears an edible fruit and contains guavin B and quercetin glycosides.Ionic Liquids: Salts that melt below 100 C. Their low VOLATILIZATION can be an advantage over volatile organic solvents.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Click Chemistry: Organic chemistry methodology that mimics the modular nature of various biosynthetic processes. It uses highly reliable and selective reactions designed to "click" i.e., rapidly join small modular units together in high yield, without offensive byproducts. In combination with COMBINATORIAL CHEMISTRY TECHNIQUES, it is used for the synthesis of new compounds and combinatorial libraries.EthersAlcohols: Alkyl compounds containing a hydroxyl group. They are classified according to relation of the carbon atom: primary alcohols, R-CH2OH; secondary alcohols, R2-CHOH; tertiary alcohols, R3-COH. (From Grant & Hackh's Chemical Dictionary, 5th ed)Flame Ionization: Pyrolysis of organic compounds at the temperature of a hydrogen-air flame to produce ionic intermediates which can be collected and the resulting ion current measured by gas chromatography.Morphine Derivatives: Analogs or derivatives of morphine.Cholestenones: CHOLESTENES with one or more double bonds and substituted by any number of keto groups.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Alkynes: Hydrocarbons with at least one triple bond in the linear portion, of the general formula Cn-H2n-2.Magnetic Resonance Spectroscopy: Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).Substance Abuse Detection: Detection of drugs that have been abused, overused, or misused, including legal and illegal drugs. Urine screening is the usual method of detection.Chemistry: A basic science concerned with the composition, structure, and properties of matter; and the reactions that occur between substances and the associated energy exchange.Benzoates: Derivatives of BENZOIC ACID. Included under this heading are a broad variety of acid forms, salts, esters, and amides that contain the carboxybenzene structure.Methods: A series of steps taken in order to conduct research.Cyanides: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.Chemical Phenomena: The composition, conformation, and properties of atoms and molecules, and their reaction and interaction processes.Acyl Coenzyme A: S-Acyl coenzyme A. Fatty acid coenzyme A derivatives that are involved in the biosynthesis and oxidation of fatty acids as well as in ceramide formation.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Fatty Acids: Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)Deuterium: Deuterium. The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.Isomerism: The phenomenon whereby certain chemical compounds have structures that are different although the compounds possess the same elemental composition. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Hydrolysis: The process of cleaving a chemical compound by the addition of a molecule of water.Reference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Kinetics: The rate dynamics in chemical or physical systems.Dinitrophenols: Organic compounds that contain two nitro groups attached to a phenol.Ascorbate Oxidase: An enzyme that converts ascorbic acid to dehydroascorbic acid. EC 1.10.3.3.Acylation: The addition of an organic acid radical into a molecule.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)PhotochemistryCatalysis: The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction.PeroxidasesCopper: A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Cycloaddition Reaction: Synthetic organic reactions that use reactions between unsaturated molecules to form cyclical products.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.
The T-bone and porterhouse are steaks of beef cut from the short loin (called the sirloin in Commonwealth countries and Ireland). Both steaks include a "T"-shaped bone with meat on each side. Porterhouse steaks are cut from the rear end of the short loin and thus include more tenderloin steak, along with (on the other side of the bone) a large strip steak. T-bone steaks are cut closer to the front, and contain a smaller section of tenderloin. The smaller portion of a T-bone, when sold alone, is known as a filet mignon, especially if it's cut from the small forward end of the tenderloin. There is little agreement among experts on how large the tenderloin must be to differentiate a T-bone steak from porterhouse. The United States Department of Agriculture's Institutional Meat Purchase Specifications state that the tenderloin of a porterhouse must be at least 1.25 inches (32 mm) thick at its widest, while that of a T-bone must be at least 0.5 inches (13 mm). However, steaks with a large tenderloin ...
ˈmiːnjɒ̃/;[1] French for "tender fillet", "delicate fillet", or fine fillet") is a steak cut of beef taken from the smaller end of the tenderloin, or psoas major of the cow carcass, usually a steer or heifer. In French this cut is always called filet de bœuf ("beef fillet") as filet mignon refers to pork tenderloin. The tenderloin runs along both sides of the spine, and is usually harvested as two long snake-shaped cuts of beef. The tenderloin is sometimes sold whole. When sliced along the short dimension, creating roughly round cuts, and tube cuts, the cuts (fillets) from the small forward end are considered to be filet mignon. Those from the center are tournedos; however, some butchers in the United States label all types of tenderloin steaks "filet mignon". In fact, the shape of the true filet mignon may be a hindrance when cooking, so most restaurants sell steaks from the wider end of the tenderloin - it is both cheaper and much more presentable. The tenderloin is the most tender cut of ...
The loins (or: lumbus) are the sides between the lower ribs and pelvis, and the lower part of the back. It is often used when describing the anatomy of humans and quadrupeds (such as horses, pigs or cattle). The anatomical reference also carries over into the description of cuts of meat from some such animals, e.g. tenderloin or sirloin steak. In human anatomy the term "loin" or "loins" refers to the side of the human body below the rib cage to just above the pelvis. It is frequently used to reference the general area below the ribs. While the term "loin" is generally not used in medical science, some names of disorders do contain it. The lumbar region of the spinal column is located in the loin area of the body. The term also has become euphemistic for human genitals because of their prominence in that anatomical region. Because of this euphemistic use of the term, the article of clothing that is worn around the genital area has been named a loincloth. In the Authorized King James Version of ...
Francis Warren Nicholls, Jr. (* 18. január 1955, Bronx, New York, USA - † 31. marec 2014, Chicago, Illinois, USA), viac známy ako Frankie Knuckles, bol americký DJ a hudobný producent.[2] Knuckles zohral významnú rolu vo vývoji a zpopularizovaní žánru house v Chicagu počas 80. rokov, keď bol house v ranom štádiu vývinu. Pre svoju dôležitú rolu vo vývoji housu bol známy ako "The Godfather of House Music."[3] V Chicagu bola preto po ňom nazvaná časť ulice. Za svoje úspechy získal Knuckles v roku 1997 cenu Grammy. V roku 2005 bol uvedený do Dance Music Hall of Fame.. Dňa 31. marca 2014 Frankie Knuckles vo veku 59 rokov zomrel na komplikácie spôsobené cukrovkou 2. typu.[4][5] Toto ochorenie získal okolo roku 2005.[6]. ...
Dry-aged beef is beef that has been hung or placed on a rack to dry for several weeks. After the animal is slaughtered and cleaned, it is hung as a full or half carcass. Primal (large distinct sections) or sub primal cuts, such as strip loins, rib eyes, and sirloin, are placed in a refrigerator unit, also known as a "hot box". This process involves considerable expense, as the beef must be stored near freezing temperatures. Subprimal cuts can be dry aged on racks either in specially climate-controlled coolers or within a moisture-permeable drybag. Moreover, only the higher grades of meat can be dry aged, as the process requires meat with a large, evenly distributed fat content. Because of this, dry-aged beef is seldom available outside of steak restaurants and upscale butcher shops or groceries. The key effect of dry aging is the concentration and saturation of the natural flavour, as well as the tenderization of the meat texture. The process changes beef by two means. Firstly, moisture is ...
The Curtius rearrangement (or Curtius reaction or Curtius degradation), first defined by Theodor Curtius in 1885, is the thermal decomposition of an acyl azide to an isocyanate with loss of nitrogen gas. The isocyanate then undergoes attack by a variety of nucleophiles such as water, alcohols and amines, to yield a primary amine, carbamate or urea derivative respectively. Several reviews have been published. The acyl azide is usually made from the reaction of acid chlorides or anydrides with sodium azide or trimethylsilyl azide. Acyl azides are also obtained from treating acylhydrazines with nitrous acid. Alternatively, the acyl azide can be formed by the direct reaction of a carboxylic acid with ...
... (phosphaethyne) is a chemical compound which was the first phosphaalkyne compound discovered, containing the unusual C≡P carbon-phosphorus triple bond. Methylidynephosphane is the phosphorus analogue of hydrogen cyanide, with the nitrile nitrogen replaced by phosphorus. Methylidynephosphane can be synthesised via the reaction of phosphine with carbon, but it is extremely reactive and polymerises readily at temperatures above −120 °C. However, several types of derivatives, with bulky groups, such as tert-butyl or trimethylsilyl, substituted for the hydrogen atom, are much more stable, and are useful reagents for the synthesis of various organophosphorus compounds. The PCO− and PCS− anions are also known. While the existence of the molecule had been discussed, and early attempts had been made to prepare it (see following), methylidynephosphane was first successfully synthesised in this protio form in 1961, by T.E. Gier of E. I. duPont de Nemours, Inc.; earlier reports ...
... , or The San Francisco Comedy Festival, is an American comedy festival founded in 2002 by Bay Area actor-comedians David Owen, Janet Varney and Cole Stratton. It takes place every January and February in a variety of Bay Area venues and features sketch comedy, improv comedy, film and television tributes and reunions, solo performers, podcasts and stand-up comedy performers. In its first year, SF Sketchfest presented six Bay Area sketch groups in the intimate 80-seat Shelton Theatre: The Fresh Robots, Kasper Hauser, The Meehan Brothers, Please Leave The Bronx, Totally False People and White Noise Radio Theatre. The Second Annual SF Sketchfest featured Fred Willard and his Hollywood Players, the Upright Citizens Brigade, The Sklar Brothers, The Vestibules and The Tenderloins performing at the 200-seat Eureka Theatre. The Third Annual SF Sketchfest featured a tribute to Amy Sedaris; a panel discussion with Bill Corbett, Kevin Murphy and Michael J. Nelson from Mystery Science Theater ...
... (Chinese: 延川县; pinyin: Yánchuān Xiàn) is a county under the administration of the prefecture-level city of Yan'an, in the northeast of Shaanxi Province, bordering Shanxi Province across the Yellow River to the east. The county spans 1,985 kilometers in area, and is home to 192,000 people as of 2017.[1] In 1969, Xi Jinping was sent to work in Liangjiahe Village [zh], Wen'anyi [zh], Yanchuan County, as part of Mao Zedong's Down to the Countryside Movement.[2][3] This has launched the county into the national spotlight, making the area a tourist site for many.[3] ...
Naʼashjéʼii éí nahasdzáán tʼáá siʼą́ą́ ńtʼę́ę́ʼ bikáaʼgi dahólǫ́; ndaʼałkaahí éí "Araneomorphae" deiłníigo deiyózhí.. Naʼashjéʼii éí tʼáá ałtso bijáád tseebíí, adóó éí bitłʼóól hólǫ́. Binááʼ éí tseebíi łeh; łaʼ éí binááʼ tʼóó hastą́ą ndi. Naʼashjéʼii éí chʼosh deildeeł łeh; łaʼ éí chʼil deiłchozh ndi, náánáłaʼ éí atsįʼ deilghał ałdóʼ.. Naʼashjéʼii éí 36,000 ánéelą́ą́ʼ alʼąą ádaatʼé.. ...
Azido azetikoa konposatu organiko bat da. Formula kimiko hau du: CH3-COOH (C2H4O2).. Kolorerik gabeko likidoa da. Azido azetikoa ozpinaren osagai nagusia da. Azido ahultzat sailkatzen den arren, kontzentrazio altuetan korrosiboa da, eta gizakiaren larruazalari kalte egin diezaioke.. Azido azetiko sinpleena azido karboxilikoa da. Konposatu garrantzitsua da erreaktiboetan eta industria kimikoan, batez ere zeluloide azetatoa, argazki filma eta polibinil azetatoa ekoizteko. Zuntz sintetikoetan ere erabil daiteke. Etxebizitzetan, diluituta erabiltzen da. Kaltzioa kentzeko (E260) azidotasun erregulatzailetzat eta ongailutzat erabiltzen da.. ...
... is a neutrally charged polynitrogen allotrope of the chemical formula N 4 and consists of four nitrogen atoms. The tetranitrogen cation is the positively charged ion, N+ 4, which is more stable than the neutral tetranitrogen and is thus more studied. The structure, stability and properties of these molecules have been of great interest to research scientists in the last ten years.[when?] Polynitrogen compounds have been well known and characterized by chemists for many years. Molecular nitrogen (N 2) was first isolated by Daniel Rutherford in 1772 and the azide ion (N− 3) was discovered by Theodor Curtius in 1890. Discoveries of other related nitrogenous allotypes during the twentieth century include the aromatic molecule pentazole and the radical molecule N• 3. However, none of these complexes could be isolated or synthesized on a macroscopic scale like N 2 and azide; it was not until 1999 that a large scale synthesis was devised for a ...
Azido maliko (HO2CCH2CHOHCO2H) landare eta fruitu ugaritan -sagar berdeetan, batik bat- izaten den bi azidodun alkohola da. Landareen eta animalien zelulen metabolismoan parte hartzen du. 100 °C-tan urtzen diren kristalak eratzen ditu, eta uretan eta alkoholean urtzen da. Sintesiz ere lor daiteke, azido maleikoa berotuz, edo azido tartarikotik, sukzinikotik eta aspartikotik.. ...
The acyl azide is usually made from the reaction of acid chlorides or anydrides with sodium azide or trimethylsilyl azide. Acyl ... which is reacted with nitrous acid to give the acyl azide. Heating the azide in ethanol yields the ethyl carbamate via the ... azides are also obtained from treating acylhydrazines with nitrous acid. Alternatively, the acyl azide can be formed by the ... used the Curtius rearrangement in one of the key steps in converting the acyl azide to the amide group in the target molecule. ...
PhN3 Alkyl or aryl acyl chlorides react with sodium azide in aqueous solution to give acyl azides, which give isocyanates in ... Aryl azides may be prepared by displacement of the appropriate diazonium salt with sodium azide, or trimethylsilyl azide; ... Protonation of azide salts gives toxic hydrazoic acid in the presence of strong acids: H+ + N− 3 → HN3 Azide salts may react ... Heavy metal azides, such as lead azide are primary high explosives detonable when heated or shaken. Heavy-metal azides are ...
Warren, J. D., Press, J. B. Trimethylsilylazide/KN3/18-crown-6. Formation and Curtius rearrangement of acyl azides from ... in toluene or benzene reacts readily with acid chlorides to give acyl azides. These are heated in solution to afford the ... The sodium azide pathway (Pathway A), Figure 4, begins with a thionylchloride treatment of the free acid to form the acyl ... acyl azides from is mentioned: [Pg.504] [Pg.935] [Pg.106] [Pg.500] [Pg.8] [Pg.804] [Pg.843] [Pg.337] [Pg.804] [Pg.216] [Pg.862] ...
... hydroxy groups were modified by the tosyl-azide exchange method. The commonly used conditions for click reaction between the ... Deoxynucleoside conjugates of 13α-estrone were synthesized by applying the copper-catalyzed alkyne-azide click reaction (CuAAC ... trimethylsilyl azide or zinc azide-pyridine complex [53] is also a possible alternative to prepare azides from nucleosides, ... 3.1.1. General Procedure for Synthesis of 3′-O-Acetyl-N-acyl-protected-2′-deoxynucleosides 8a-d. 10 mmol of 5′-O-DMTr-N-acyl- ...
The chemistry of azides has been reviewed several times, some of these overviews focus only on one subclass of azides.1 The ... The (R)-β-azidophenylethanols 11-15 (1.0 mmol), 2-(trimethylsilyl)phenyl triflate (1.5 mmol, 0.45 g), acetonitrile (5 mL) and ... vinyl acetate as the acyl donor and hexane as solvent in an orbital shaker. The results are shown in Table 1. The development ... and the chemical shifts were given in ppm using tetramethylsilane (TMS) as internal standard. Infrared (IR) spectra were ...
In this study, azide ω-functional PEG-b-PS121 or PEG-b-PtBA122 diblock copolymers were synthesized by ATRP from a PEG-based ... 5) in the presence of CuBr/bpy as the catalyst to give the corresponding PHEMA (Mn = 3.9, 7.9, 15.7 kDa, Mw/Mn = 1.20-1.25) ... 24 Structure of sugar azides used for the synthesis of glycopolymers by a combination of CLRP and click chemistry.. ... N-acyl switch that guided the self assembly of the bioconjugate into densely twisted tapelike microstructures.101 AFM and TEM ...
Examples of electrophilic latent reactive groups include, but are not limited to, acyl sulfonamides (RCONHSO2R′), acyl azides ( ... The solution was filtered through a 0.25 micron filter and the solvent was removed under reduced pressure to give atan solid ( ... The solid was dried, and (trimethylsilyl)diazomethane (TMSCHN2, 35 μL, 0.0702 mmol, Aldrich) and methanol (350 μL) were added ... R6 can include a latent reactive group selected from an azide, a nitro group, a disulfide, a hydrazine, a hydrazide, a ...
The use of t-BuOK in wet DMF as desilylating reagent in a cycloaddition reaction of aromatic azides and trimethylsilyl alkynes ... N-N bond formation and an acyl migration-based C-C bond formation. This metal- and azide-free method proceeds in the presence ... A ruthenium-catalyzed cycloaddition of N-Boc ynamides with azides gives protected 5-amino-1,2,3-triazole-4-carboxylic acids, ... A copper-catalyzed three-component reaction of methyl ketones, organic azides, and DMF as one-carbon (C1) donor provides 4-acyl ...
Preferably, a given reactive group will react with a given complementary reactive group exactly once. In one embodiment, ... For example, a building block including an alkyne can be reacted with an organic azide, or a building block including an azide ... The acyl groups can also be activated in situ, as is known in the art, by reaction with a suitable activating compound. ... One example of such complementary reactive groups are alkynes and organic azides, which react under suitable conditions to form ...
... to give the pentasulfated pentasaccharide API2-CB. The intermediate API2-CB was then hydrogenated to reduce the three azides on ... An improved method for the simultaneous removal of O-benzyl and N-carboxybenzyl groups as well as reducing azide groups to ... In this strategy, all of the hydroxyl groups that are to be sulfated are protected with an acyl protective group, for example, ... The reactor was purged with nitrogen and was chilled to 0° C., after which 2598 mL of trimethylsilyl iodide (TMSI, 3636 g, 18 ...
... because the azide group is introduced only later and so the special precautionary measures to be taken when using azides are ... Special preference is given to the compounds 1d, 1e, 2a, 2b, 2c, 2d, 2e, 2f, 3a, 3b, 3d, 3e, 4a, 4b, 6a, 6b, 6c, 6d, 6e, 6f, ... Suitable hydroxy-protecting groups are especially selected from those of the acyl or ester type, e.g. lower alkanoyl, such as ... trimethylsilyl)ethoxy]ethyl, 1-methyl-1-methoxyethyl, 1-methyl-1-benzyloxyethyl, 1-methyl-1-benzyloxy-2-fluoroethyl, 1-methyl-1 ...
The downsizing of the 42-mer peptide to an 11-mer and the incorporation of three Aoc residues gave rise to a KD of 550 nM, ... Esterification was achieved via the acyl chloride method and via alkylation of SWNT-(COO-)n, the latter being the more ... Finally, tris(trimethylsilyl)silylmethaneamide (hypersilylamide) together with catalytic amounts of triflic acid were found to ... Parallelly to amide coupling reactions, copper(I)-catalyzed alkyne azide cycloaddition is used for fast and high-yielding late- ...
The hazards associated with hydrazoic acid are essentially eliminated, shock-sensitive metal azides such as zinc (II) azide are ... A fast and efficient high temperature protocol for the ring opening of 2-oxazolines to generate mono-acyl 1,4-diamines under ... Their approach involves the in situ generation of hydrazoic acid by methanolysis of trimethylsilylazide and concomitant ... They found that both glass microreactors and stainless steel coil reactors were equally effective, the latter giving a higher ...
Aryl alkyl alkynes reacted with N-iodosuccinimide (NIS) and trimethylsilyl azide (TMSN₃), leading to α,α-diazidoketones via the ... ortho-Lithiation of N-Boc-3-bromopyrroles (7b, 7d) with LDA in THF at −75°C, followed by reactions with ethyl formate gave ... regioselectivity, etc ; azides; chemical structure; cycloaddition reactions; oxidation; Show all 5 Subjects. Abstract:. ... A ... an acyl, or another electron withdrawing group. The triple bond polarization renders ynamides broadly useful building blocks ...
As 1,2-acyl or -phosphoryl migration is preferred, single regioisomers are obtained. Furthermore, in the presence of a Lewis ... Given the prevalence of amides in pharmaceuticals and natural products, we anticipate that this method will simplify the ... Copper(I)-catalyzed azide-alkyne cycloaddition has become a commonly employed method for the synthesis of complex molecular ... In this report, we demonstrate the use of commercially available tris(trimethylsilyl)silane with metallaphotoredox catalysis to ...
The IRC gives a unique connection from a given transition structure to local minima of the reactant and product sides. This ... A mechanism for the formation of silanimine from the reaction of silylene and azide is discussed using theoretical calculations ... trimethylsilyl)butane-1,4-diyl) were synthesized as air-sensitive crystals by the reaction of isolable dialkylsilylene 4 with ... typically lack the electron-withdrawing inductive effects needed to participate in nucleophilic acyl substitution reactions. ...
The required azides were prepared via the reaction of aryl amine with sodium nitrite, HCl & Sodium azide. The synthesized ... These dyes give a wide range of orange to violet shades on each fibres. All dyes were identified by spectroscopic technique and ... Complexes Involving Acyl pyrazoline-5-one Derivatives and Substituted b-diketoenolates: Synthesis, Spectral, Thermal ... and sulphur in presence of morpholine followed by the treatment of the diazotized amine function with trimethylsilylazide. Due ...
Boron azides in Staudinger oxidations and cycloadditions. Abstract Stephan, Douglas W. Department of Chemistry and University ... Mild P4 activation to give an anionic diphosphorus complex with a dual binding ability at a single P site. Abstract ... Cycloaddition reactions between dicyclohexylboron azide and alkynes. Abstract Stephan, Douglas W. Department of Chemistry and ... Cp*Rh-based heterometallic metallarectangles: size-dependent Borromean link structures and catalytic acyl transfer. Abstract ...
A metal bis(trimethylsilyl)amide/Cs2CO3 co-catalyzed benzylation of in situ generated N-(trimethylsilyl) aldimines with toluene ... Obviously, this reaction only proceeds if one carbonyl compound reacts faster with the amine to give an imine, and the other ... A copper(I)-mediated tandem three-component reaction using alkynes, azides, allyl iodides, CuI and NaNH2 provides 5-allyl-1,2,3 ... The C-H bond thionation of α-azido ketones with elemental sulfur could form α-ketothioacyl azide, which was then ...
... enamines with trimethylsilylazide was realized to give the target products with good yields. [ DOI ] ... More ionic metal azides (N1, Mg, Al, Sc, Ni, Yb) tend to react by initial nucleophilic attack of N3− anion on the silicon atom ... Depending on the nature of metal and the [M]/N3− ratio, addition of the azide ion to the C,C-double bond proceeds with ... Acylation of cyclic nitronates with acyl bromides produces 3‐bromomethyl‐substituted 5,6‐dihydro‐2H‐1,2‐oxazines via an unusual ...