Inflammation of gum tissue (GINGIVA) without loss of connective tissue.
A wedge-shaped collar of epithelial cells which form the attachment of the gingiva to the tooth surface at the base of the gingival crevice.
Non-inflammatory enlargement of the gingivae produced by factors other than local irritation. It is characteristically due to an increase in the number of cells. (From Jablonski's Dictionary of Dentistry, 1992, p400)
Exposure of the root surface when the edge of the gum (GINGIVA) moves apically away from the crown of the tooth. This is common with advancing age, vigorous tooth brushing, diseases, or tissue loss of the gingiva, the PERIODONTAL LIGAMENT and the supporting bone (ALVEOLAR PROCESS).
Excessive growth of the gingiva either by an increase in the size of the constituent cells (GINGIVAL HYPERTROPHY) or by an increase in their number (GINGIVAL HYPERPLASIA). (From Jablonski's Dictionary of Dentistry, 1992, p574)
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
Surgical reshaping of the gingivae and papillae for correction of deformities (particularly enlargements) and to provide the gingivae with a normal and functional form, the incision creating an external bevel. (Dorland, 28th ed)
Surgical excision of the gingiva at the level of its attachment, thus creating new marginal gingiva. This procedure is used to eliminate gingival or periodontal pockets or to provide an approach for extensive surgical interventions, and to gain access necessary to remove calculus within the pocket. (Dorland, 28th ed)
Abnormal enlargement or overgrowth of the gingivae brought about by enlargement of existing cells.
Any restorative and replacement device that is used as a therapeutic aid in the treatment of periodontal disease. It is an adjunct to other forms of periodontal therapy and does not cure periodontal disease by itself. (Boucher's Clinical Dental Terminology, 3d ed)
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
A loss of mucous substance of the mouth showing local excavation of the surface, resulting from the sloughing of inflammatory necrotic tissue. It is the result of a variety of causes, e.g., denture irritation, aphthous stomatitis (STOMATITIS, APHTHOUS); NOMA; necrotizing gingivitis (GINGIVITIS, NECROTIZING ULCERATIVE); TOOTHBRUSHING; and various irritants. (From Jablonski, Dictionary of Dentistry, 1992, p842)
A fluid occurring in minute amounts in the gingival crevice, believed by some authorities to be an inflammatory exudate and by others to cleanse material from the crevice, containing sticky plasma proteins which improve adhesions of the epithelial attachment, have antimicrobial properties, and exert antibody activity. (From Jablonski, Illustrated Dictionary of Dentistry, 1982)
A numerical rating scale for classifying the periodontal status of a person or population with a single figure which takes into consideration prevalence as well as severity of the condition. It is based upon probe measurement of periodontal pockets and on gingival tissue status.
The thickest and spongiest part of the maxilla and mandible hollowed out into deep cavities for the teeth.
The anteriorly located rigid section of the PALATE.
Surgical procedures used to treat disease, injuries, and defects of the oral and maxillofacial region.
The third tooth to the left and to the right of the midline of either jaw, situated between the second INCISOR and the premolar teeth (BICUSPID). (Jablonski, Dictionary of Dentistry, 1992, p817)
The flowing of blood from the marginal gingival area, particularly the sulcus, seen in such conditions as GINGIVITIS, marginal PERIODONTITIS, injury, and ASCORBIC ACID DEFICIENCY.
A dental specialty concerned with the histology, physiology, and pathology of the tissues that support, attach, and surround the teeth, and of the treatment and prevention of disease affecting these tissues.
Cancer or tumors of the MAXILLA or upper jaw.
A procedure for smoothing of the roughened root surface or cementum of a tooth after subgingival curettage or scaling, as part of periodontal therapy.
Photographic techniques used in ORTHODONTICS; DENTAL ESTHETICS; and patient education.
An abnormal extension of a gingival sulcus accompanied by the apical migration of the epithelial attachment and bone resorption.
Tissue that supports and binds other tissues. It consists of CONNECTIVE TISSUE CELLS embedded in a large amount of EXTRACELLULAR MATRIX.
One of a pair of irregularly shaped bones that form the upper jaw. A maxillary bone provides tooth sockets for the superior teeth, forms part of the ORBIT, and contains the MAXILLARY SINUS.
Tumors or cancer of the MANDIBLE.
Chronic inflammation and loss of PERIODONTIUM that is associated with the amount of DENTAL PLAQUE or DENTAL CALCULUS present. Chronic periodontitis occurs mostly in adults and was called adult periodontitis, but this disease can appear in young people.
A benign central bone tumor, usually of the jaws (especially the mandible), composed of fibrous connective tissue within which bone is formed.
Orthodontic techniques used to correct the malposition of a single tooth.
Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
A mixed radiolucent-radiopaque lesion of the jaws with features of both a cyst and a solid neoplasm. It is characterized microscopically by an epithelial lining showing a palisaded layer of columnar basal cells, presence of ghost cell keratinization, dentinoid, and calcification. (Stedman, 25th ed)
The emergence of a tooth from within its follicle in the ALVEOLAR PROCESS of the MAXILLA or MANDIBLE into the ORAL CAVITY. (Boucher's Clinical Dental Terminology, 4th ed)
Loss or destruction of periodontal tissue caused by periodontitis or other destructive periodontal diseases or by injury during instrumentation. Attachment refers to the periodontal ligament which attaches to the alveolar bone. It has been hypothesized that treatment of the underlying periodontal disease and the seeding of periodontal ligament cells enable the creating of new attachment.
The largest and strongest bone of the FACE constituting the lower jaw. It supports the lower teeth.
Tumors or cancer of the MOUTH.
Inflammation and loss of PERIODONTIUM that is characterized by rapid attachment loss and bone destruction in the presence of little local factors such as DENTAL PLAQUE and DENTAL CALCULUS. This highly destructive form of periodontitis often occurs in young people and was called early-onset periodontitis, but this disease also appears in old people.
Either of the two fleshy, full-blooded margins of the mouth.
Data collected during dental examination for the purpose of study, diagnosis, or treatment planning.
The structures surrounding and supporting the tooth. Periodontium includes the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.
An immature epithelial tumor of the JAW originating from the epithelial rests of Malassez or from other epithelial remnants of the ENAMEL from the developmental period. It is a slowly growing tumor, usually benign, but displays a marked propensity for invasive growth.
An index which scores the degree of dental plaque accumulation.
The visually perceived property of objects created by absorption or reflection of specific wavelengths of light.
Devices used for influencing tooth position. Orthodontic appliances may be classified as fixed or removable, active or retaining, and intraoral or extraoral. (Boucher's Clinical Dental Terminology, 4th ed, p19)
The part of a tooth from the neck to the apex, embedded in the alveolar process and covered with cementum. A root may be single or divided into several branches, usually identified by their relative position, e.g., lingual root or buccal root. Single-rooted teeth include mandibular first and second premolars and the maxillary second premolar teeth. The maxillary first premolar has two roots in most cases. Maxillary molars have three roots. (Jablonski, Dictionary of Dentistry, 1992, p690)
The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.
Zirconium. A rather rare metallic element, atomic number 40, atomic weight 91.22, symbol Zr. (From Dorland, 28th ed)
A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.
The most posterior teeth on either side of the jaw, totaling eight in the deciduous dentition (2 on each side, upper and lower), and usually 12 in the permanent dentition (three on each side, upper and lower). They are grinding teeth, having large crowns and broad chewing surfaces. (Jablonski, Dictionary of Dentistry, 1992, p821)
A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Any technique by which an unknown color is evaluated in terms of standard colors. The technique may be visual, photoelectric, or indirect by means of spectrophotometry. It is used in chemistry and physics. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
Oral tissue surrounding and attached to TEETH.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
Elements of limited time intervals, contributing to particular results or situations.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

Treponema denticola outer membrane enhances the phagocytosis of collagen-coated beads by gingival fibroblasts. (1/958)

Human gingival fibroblasts (HGFs) degrade collagen fibrils in physiological processes by phagocytosis. Since Treponema denticola outer membrane (OM) extract perturbs actin filaments, important structures in phagocytosis, we determined whether the OM affects collagen phagocytosis in vitro by HGFs. Phagocytosis was measured by flow cytometric assessment of internalized collagen-coated fluorescent latex beads. Confluent HGFs pretreated with T. denticola ATCC 35405 OM exhibited an increase in the percentage of collagen phagocytic cells (phagocytosis index [PI]) and in the number of beads per phagocytosing cell (phagocytic capacity [PC]) compared with untreated controls. The enhancement was swift (within 15 min) and was still evident after 1 day. PI and PC of HGFs for bovine serum albumin (BSA)-coated beads were also increased, indicating a global increase in phagocytic processes. These results contrasted those for control OM from Veillonella atypica ATCC 17744, which decreased phagocytosis. The T. denticola OM-induced increase in bead uptake was eliminated by heating the OM and by depolymerization of actin filaments by cytochalasin D treatment of HGFs. Fluid-phase accumulation of lucifer yellow was enhanced in a saturable, concentration-dependent, transient manner by the T. denticola OM. Our findings were not due to HGF detachment or cytotoxicity in response to the T. denticola OM treatment since the HGFs exhibited minimal detachment from the substratum; they did not take up propidium iodide; and there was no change in their size, granularity, or content of sub-G1 DNA. We conclude that a heat-sensitive component(s) in T. denticola OM extract stimulates collagen phagocytosis and other endocytic processes such as nonspecific phagocytosis and pinocytosis by HGFs.  (+info)

Lipoteichoic acid acts as an antagonist and an agonist of lipopolysaccharide on human gingival fibroblasts and monocytes in a CD14-dependent manner. (2/958)

CD14 has been implicated as a receptor of lipoteichoic acid (LTA) and other bacterial components as well as lipopolysaccharide (LPS). Since the structures of LTAs from various gram-positive bacteria are heterogeneous, we analyzed the effects of LTAs on the secretion of interleukin-8 (IL-8) by high- and low-CD14-expressing (CD14(high) and CD14(low)) human gingival fibroblasts (HGF). While Bacillus subtilis LTA had an IL-8-inducing effect on CD14(high) HGF which was considerably weaker than that of LPS, Streptococcus sanguis and Streptococcus mutans LTAs had practically no effect on the cells. B. subtilis LTA had only a weak effect on CD14(low) HGF, as did LPS. S. sanguis and S. mutans LTAs at a 1,000-fold excess each completely inhibited the IL-8-inducing activities of both LPS and a synthetic lipid A on CD14(high) HGF. The effect of LPS was also inhibited by the presence of an LPS antagonist, synthetic lipid A precursor IVA (LA-14-PP), with a 100-fold higher potency than S. sanguis and S. mutans LTAs and by anti-CD14 monoclonal antibody (MAb). S. sanguis and S. mutans LTAs, LA-14-PP, and anti-CD14 MAb had no significant effect on phorbol myristate acetate-stimulated IL-8 secretion by HGF. These LTAs also inhibited the IL-8-inducing activity of B. subtilis LTA on CD14(high) HGF, as did LA-14-PP and anti-CD14 MAb. The antagonistic and agonistic functions of LTAs were also observed with human monocytes. Binding of fluorolabeled LPS to human monocytes was inhibited by S. sanguis LTA, although the inhibition was 100 times weaker than that of LPS itself, and anti-CD14 MAb inhibited fluorolabeled LPS and S. sanguis LTA binding. Binding of LTAs to CD14 was also observed with nondenaturing polyacrylamide gel electrophoresis. These results indicate that LTAs act as antagonists or agonists via a CD14-dependent mechanism, probably due to the heterogeneous structure of LTAs, and that an antagonistic LTA might be a useful agent for suppressing the periodontal disease caused by gram-negative bacteria.  (+info)

Targeted disruption of fibronectin-integrin interactions in human gingival fibroblasts by the RI protease of Porphyromonas gingivalis W50. (3/958)

Cell surface integrins mediate interactions between cells and their extracellular matrix and are frequently exploited by a range of bacterial pathogens to facilitate adherence and/or invasion. In this study we examined the effects of Porphyromonas gingivalis proteases on human gingival fibroblast (HGF) integrins and their fibronectin matrix. Culture supernatant from the virulent strain W50 caused considerably greater loss of the beta1 integrin subunit from HGF in vitro than did that of the beige-pigmented strain W50/BE1. Prior treatment of the W50 culture supernatant with the protease inhibitor Nalpha-p-tosyl-L-lysine chloromethyl ketone (TLCK) blocked its effects on cultured cells, indicating that this process is proteolytically mediated. Purified arginine-specific proteases from P. gingivalis W50 were able to mimic the effects of the whole-culture supernatant on loss of beta1 integrin expression. However purified RI, an alpha/beta heterodimer in which the catalytic chain is associated with an adhesin chain, was 12 times more active than RIA, the catalytic monomer, in causing loss of the alpha5beta1 integrin (fibronectin receptor) from HGF. No effect was observed on the alphaVbeta3 integrin (vitronectin receptor). The sites of action of RI and RIA were investigated in cells exposed to proteases pretreated with TLCK to inactivate the catalytic component. Use of both monoclonal antibody 1A1, which recognizes only the adhesin chain of RI, and a rabbit antibody against P. gingivalis whole cells indicated localization of RI on the fibroblasts in a clear, linear pattern typical of that seen with fibronectin and alpha5beta1 integrin. Exact colocalization of RI with fibronectin and its alpha5beta1 receptor was confirmed by double labeling and multiple-exposure photomicroscopy. In contrast, RIA bound to fibroblasts in a weak, patchy manner, showing only fine linear or granular staining. It is concluded that the adhesin component of RI targets the P. gingivalis arginine-protease to sites of fibronectin deposition on HGF, contributing to the rapid loss of both fibronectin and its main alpha5beta1 integrin receptor. Given the importance of integrin-ligand interactions in fibroblast function, their targeted disruption by RI may represent a novel mechanism of damage in periodontal disease.  (+info)

The potential role of chemokines and inflammatory cytokines in periodontal disease progression. (4/958)

Inflammation is regulated by the expression of mediators that cause a number of pleiotropic events culminating in the recruitment of inflammatory cells and release of biologic mediators by leukocytes. If the inflammation is transient in nature, it can protect the host by activating defense mechanisms and initiating wound repair. However, if the inflammation is inappropriate, it can lead to considerable tissue damage. My colleagues and I have investigated the role of chemokines, particularly monocyte chemoattractant protein 1, in various pathological processes and the role of the proinflammatory cytokines interleukin-1 (IL-1) and tumor necrosis factor (TNF) in experimental periodontitis. I will discuss first the studies on chemokines and then the use of IL-1 and TNF blockers in inhibiting inflammation and bone loss in the periodontium.  (+info)

Induction of prostaglandin release from macrophages by bacterial endotoxin. (5/958)

This review summarizes the role of the monocytic responses to lipopolysaccharide as it relates to periodontal disease severity. Data are presented which illustrate that the levels of prostaglandin E2 (PGE2) secreted by systemic peripheral blood monocytes in culture, in the presence of bacterial endotoxins, are highly correlated with the levels observed in the gingival crevicular fluid. Furthermore, the different periodontal diagnostic categories have varying levels of monocytic and crevicular fluid PGE2, in juxtaposition with clinical disease severity. These data are consistent with the concept that there is close synchrony between the systemic responsiveness of peripheral blood monocytes with regard to prostanoid synthesis and the local levels of mediator present within the gingival crevice.  (+info)

Production of beta-defensin antimicrobial peptides by the oral mucosa and salivary glands. (6/958)

beta-Defensins are cationic peptides with broad-spectrum antimicrobial activity that are produced by epithelia at mucosal surfaces. Two human beta-defensins, HBD-1 and HBD-2, were discovered in 1995 and 1997, respectively. However, little is known about the expression of HBD-1 or HBD-2 in tissues of the oral cavity and whether these proteins are secreted. In this study, we characterized the expression of HBD-1 and HBD-2 mRNAs within the major salivary glands, tongue, gingiva, and buccal mucosa and detected beta-defensin peptides in salivary secretions. Defensin mRNA expression was quantitated by RNase protection assays. HBD-1 mRNA expression was detected in the gingiva, parotid gland, buccal mucosa, and tongue. Expression of HBD-2 mRNA was detected only in the gingival mucosa and was most abundant in tissues with associated inflammation. To test whether beta-defensin expression was inducible, gingival keratinocyte cell cultures were treated with interleukin-1beta (IL-1beta) or bacterial lipopolysaccharide (LPS) for 24 h. HBD-2 expression increased approximately 16-fold with IL-1beta treatment and approximately 5-fold in the presence of LPS. Western immunoblotting, liquid chromatography, and mass spectrometry were used to identify the HBD-1 and HBD-2 peptides in human saliva. Human beta-defensins are expressed in oral tissues, and the proteins are secreted in saliva; HBD-1 expression was constitutive, while HBD-2 expression was induced by IL-1beta and LPS. Human beta-defensins may play an important role in the innate defenses against oral microorganisms.  (+info)

Transcriptional activation of mRNA of intercellular adhesion molecule 1 and induction of its cell surface expression in normal human gingival fibroblasts by Mycoplasma salivarium and Mycoplasma fermentans. (7/958)

Lipoproteins in the cell membranes of both Mycoplasma salivarium and Mycoplasma fermentans were demonstrated to trigger the transcription of intercellular adhesion molecule-1 mRNA in normal fibroblasts isolated from human gingival tissue and to induce its cell surface expression by a mechanism distinct from that of Escherichia coli lipopolysaccharide. The lipid moiety of the lipoproteins was suggested to play a key role in the expression of the activity.  (+info)

Overgrowth of oral mucosa and facial skin, a novel feature of aspartylglucosaminuria. (8/958)

Aspartylglucosaminuria (AGU) is a lysosomal storage disorder caused by deficiency of aspartylglucosaminidase (AGA). The main symptom is progressive mental retardation. A spectrum of different mutations has been reported in this disease, one missense mutation (Cys163Ser) being responsible for the majority of Finnish cases. We were able to examine 66 Finnish AGU patients for changes in the oral mucosa and 44 of these for changes in facial skin. Biopsy specimens of 16 oral lesions, 12 of them associated with the teeth, plus two facial lesions were studied histologically. Immunohistochemical staining for AGA was performed on 15 oral specimens. Skin was seborrhoeic in adolescent and adult patients, with erythema of the facial skin already common in childhood. Of 44 patients, nine (20%) had facial angiofibromas, tumours primarily occurring in association with tuberous sclerosis. Oedemic buccal mucosa (leucoedema) and gingival overgrowths were more frequent in AGU patients than in controls (p<0.001). Of 16 oral mucosal lesions studied histologically, 15 represented fibroepithelial or epithelial hyperplasias and were reactive in nature. Cytoplasmic vacuolisation was evident in four. Immunohistochemically, expression of AGA in AGU patients' mucosal lesions did not differ from that seen in corresponding lesions of normal subjects. Thus, the high frequency of mucosal overgrowth in AGU patients does not appear to be directly associated with lysosomal storage or with alterations in the level of AGA expression.  (+info)

TY - JOUR. T1 - Impaired degradation of matrix collagen in human gingival fibroblasts by the antiepileptic drug phenytoin. AU - Kato, Takahiro. AU - Okahashi, Nobuo. AU - Kawai, Shinji. AU - Kato, Takafumi. AU - Inaba, Hiroaki. AU - Morisaki, Ichijiro. AU - Amano, Atsuo. N1 - Copyright: Copyright 2008 Elsevier B.V., All rights reserved.. PY - 2005/6. Y1 - 2005/6. N2 - Background: Gingival overgrowth (GO) is a serious adverse effect associated with the administration of phenytoin (PHT), with PHT-induced GO characterized by a massive accumulation of extracellular matrix components, especially collagen, in gingival connective tissues. However, the etiology of such collagen accumulation is still largely unknown. We examined the effects of PHT on the collagen degradation process leading to collagen accumulation in human gingival fibroblasts (HGF). Methods: HGFs were cultured with various concentrations of PHT and viable cell numbers and collagen amounts were determined. Gene and protein expressions ...
Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) cells. Quantitative immunostaining revealed the need for a high multiplicity of infection for optimal infection. Early in infection (2-12 h), P. gingivalis activated the proinflammatory transcription factor NF-kappa B, partly via the PI3 kinase/AKT pathway. This was accompanied by the induction of cellular anti-apoptotic genes, including Bfl-1, Boo, Bcl-XL, Bcl2, Mcl-1, Bcl-w and Survivin. Late in infection (24-36 h) the anti-apoptotic genes largely shut down and the pro-apoptotic genes, including Nip3, Hrk, Bak, Bik, Bok, Bax, Bad, Bim and Moap-1, were activated. Apoptosis was characterized by nuclear DNA degradation and activation of caspases-3, -6, -7 and -9 via the intrinsic mitochondrial pathway. Use of
Porphyromonas gingivalis is the foremost oral pathogen of adult periodontitis in humans. However, the mechanisms of bacterial invasion and the resultant destruction of the gingival tissue remain largely undefined. We report host-P. gingivalis interactions in primary human gingival fibroblast (HGF) cells. Quantitative immunostaining revealed the need for a high multiplicity of infection for optimal infection. Early in infection (2-12 h), P. gingivalis activated the proinflammatory transcription factor NF-kappa B, partly via the PI3 kinase/AKT pathway. This was accompanied by the induction of cellular anti-apoptotic genes, including Bfl-1, Boo, Bcl-XL, Bcl2, Mcl-1, Bcl-w and Survivin. Late in infection (24-36 h) the anti-apoptotic genes largely shut down and the pro-apoptotic genes, including Nip3, Hrk, Bak, Bik, Bok, Bax, Bad, Bim and Moap-1, were activated. Apoptosis was characterized by nuclear DNA degradation and activation of caspases-3, -6, -7 and -9 via the intrinsic mitochondrial pathway. Use of
TY - JOUR. T1 - A major human oral lysophosphatidic acid species, LPA 18:1, regulates novel genes in human gingival fibroblasts. AU - Cerutis, D. Roselyn. AU - Weston, Michael D.. AU - Alnouti, Yazen. AU - Bathena, Sai P.. AU - Nunn, Martha E.. AU - Ogunleye, Afolabi O.. AU - McVaney, Timothy P.. AU - Headen, Karmel V.. AU - Miyamoto, Takanari. PY - 2015/5/1. Y1 - 2015/5/1. N2 - Background: The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both normal physiology and inflammation in many systems. However, its actions are just beginning to be defined in oral biology and pathophysiology. Methods: Microarray analysis was used to test the hypothesis that human gingival fibroblasts (GFs) would show significant changes in wound-healing and inflammation-related gene transcripts in response to a major human salivary and gingival crevicular fluid LPA species, 18:1, and that they would express transcript for the major LPA-producing enzyme autotaxin. The microarray results were ...
BACKGROUND AND AIM: An important goal of periodontal plastic surgery is the creation of attached gingiva around the teeth. In this study, the aims were to culture gingival fibroblasts in a biodegradable scaffold and measure the width of attached gingiva after the clinical procedure.METHODS: This study was carried out on 4 patients (8 sites), with inadequate attached gingiva next to at least two teeth in contralateral quadrants of the same jaw. A biopsy of attached gingiva (epithelial + connective tissue) was taken using a surgical blade. Following culture of gingival fibroblasts, 250 × 103 cells in 250 µl nutritional medium were mixed with platelet-rich in growth factor (PRGF). Periosteal fenestration technique was done on one side (control) and tissue-engineered mucosal graft (test) was carried out on the contralateral side in each patient. The width of keratinized tissue, probing depth (PD) and width of attached gingiva were recorded at baseline and 3 months after the operation.RESULTS: An increased
TY - JOUR. T1 - Nitric oxide inhibits androgen receptor-mediated collagen production in human gingival fibroblasts. AU - Lin, S. J.. AU - Lu, H. K.. AU - Lee, H. W.. AU - Chen, Y. C.. AU - Li, C. L.. AU - Wang, Leng-Fang. PY - 2012/12. Y1 - 2012/12. N2 - Background and Objective: In our previous study, we found that flutamide [an androgen receptor (AR) antagonist] inhibited the up-regulation of collagen induced by interleukin (IL)-1β and/or nifedipine in gingival fibroblasts. The present study attempted to verify the role of nitric oxide (NO) in the IL-1β/nifedipine-AR pathway in gingival overgrowth. Material and Methods: Confluent gingival fibroblasts derived from healthy individuals (n=4) and those with dihydropyridine-induced gingival overgrowth (DIGO) (n=6) were stimulated for 48h with IL-1β (10ng/mL), nifedipine (0.34μm) or IL-1β + nifedipine. Gene and protein expression were analyzed with real-time RT-PCR and western blot analyses, respectively. Meanwhile, Sircol dye-binding and the ...
Nitric oxide synthase type-II is synthesized by human gingival tissue and cultured human gingival fibroblasts.: Nitric oxide is known to be an important inflamm
Gomez-Florit, Manuel; Ramis, Joana Maria; Xing, Rui; Taxt-Lamolle, Sebastien Francis Michel; Haugen, Håvard Jostein; Lyngstadaas, Ståle Petter & Monjo Cabrer, Marta (2014). Differential response of human gingival fibroblasts to titanium- and titanium-zirconium-modified surfaces. Journal of Periodontal Research. ISSN 0022-3484. 49(4), s 425- 436 . doi: 10.1111/jre.12121 Vis sammendrag Background and Objective: Gingival fibroblasts are responsible for the constant adaptation, wound healing and regeneration of gingival connective tissue. New titanium-zirconium (TiZr) abutment surfaces have been designed to improve soft tissue integration and reduce implant failure compared with titanium (Ti). The aim of the present study was firstly to characterize a primary human gingival fibroblasts (HGF) model and secondly to evaluate their differential response to Ti and TiZr polished (P), machined (M), and machined + acid-etched (modMA) surfaces, respectively. Material and Methods: HGF were cultured on ...
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In periodontal therapy, the use of low-level diode lasers has recently been considered to improve wound healing of the gingival tissue. However, its effects on human gingival epithelial cells (HGECs)...
Alpha-melanocyte stimulating hormone (α-MSH) is involved in normal skin wound healing and also has anti-inflammatory properties. The association of α-MSH to polyelectrolyte layers with various supports has been shown to improve these anti-inflammatory properties. This study aimed to evaluate the effects of nanofibrous membrane functionalized with α-MSH linked to polyelectrolyte layers on gingival cell inflammatory response. Human oral epithelial cells (EC) and fibroblasts (FB) were cultured on plastic or electrospun Poly-#-caprolactone (PCL) membranes with α-MSH covalently coupled to Poly-L-glutamic acid (PGA-α-MSH), for 6 to 24 h. Cells were incubated with or without Porphyromonas gingivalis lipopolysaccharide (Pg-LPS). Cell proliferation and migration were determined using AlamarBlue test and scratch assay. Expression of interleukin-6 (IL-6), tumor necrosis factor (TNF-α), and transforming growth factor-beta (TGF-β) was evaluated using RT-qPCR method. Cell cultures on plastic showed that PGA-α
Irsogladine maleate (IM) counters Aggregatibacter actinomycetemcomitans-induced reduction of the gap junction intercellular communication and the expression of zonula occludens-1, which is a major tight junction structured protein, in cultured human gingival epithelial cells (HGEC). In addition, IM obviates the A. actinomycetemcomitans-induced increase in interleukin (IL)-8 levels in HGEC. Thus, by regulating the intercellular junctional complex and chemokine secretion in HGEC, IM may be useful to prevent periodontal disease. To clarify the effects and regulatory mechanism of IM in vivo and in vitro, we examined the expression of E-cadherin and neutrophil chemotaxis induced by A. actinomycetemcomitans under IM pretreatment. Immunohistochemical studies revealed that A. actinomycetemcomitans application to the gingival sulcus decreased the number of cells positive for E-cadherin and increased those positive for cytokine-induced neutrophil chemoattractant-2α (CINC-2α) in rat gingival epithelium ...
Preventive Effect of Daiokanzoto TJ-84 on 5-Fluorouracil-Induced Human Gingival Cell Death through the Inhibition of Reactive Oxygen Species Production. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
DOI: 10.11607/prd.00.0824 Cultured gingival dermal substitute (CGDS), composed of gingival fibroblasts and matrix and fabricated using tissue-engineering techniques, has been used for root coverage procedures. Fourteen sites from four patients with ≥ 2 mm of Miller Class I or II facial gingival tissue recession were treated. The autologous CGDS sheet, prepared prior to surgical treatment, was grafted over the teeth with gingival recession and then covered with a coronally positioned flap. Vertical and horizontal recession was measured at baseline (prior to the surgical procedure) and 13 to 40 weeks (average: 30.7 9.6 weeks) after surgery. The average vertical and horizontal root coverage after surgery was 79.1% 25.7% and 75.2% 31.4%, respectively. Moreover, there was a significant increase of keratinized and attached gingival tissue at the final clinical evaluation compared with preoperative measurements (P < .05). These results demonstrate CGDS as a promising grafting material for use with ...
Wound healing is a dynamic process that involves highly coordinated cellular events, including proliferation and migration. Oral gingival fibroblasts serve a central role in maintaining oral mucosa homeostasis, and their functions include the coordination of physiological tissue repair. Recently, surface pre‑reacted glass‑ionomer (S‑PRG) fillers have been widely applied in the field of dental materials for the prevention of dental caries, due to an excellent ability to release fluoride (F). In addition to F, S‑PRG fillers are known to release several types of ions, including aluminum (Al), boron (B), sodium (Na), silicon (Si) and strontium (Sr). However, the influence of these ions on gingival fibroblasts remains unknown. The aim of the present study was to examine the effect of various concentrations of an S‑PRG filler eluate on the growth and migration of gingival fibroblasts. The human gingival fibroblast cell line HGF‑1 was treated with various dilutions of an eluent solution of ...
in Journal of Periodontal Research (1999), 34(6), 323-8. Several grafting techniques and guided tissue regeneration techniques (GTR) have been well-developed in periodontal surgery. However, these techniques could induce pain and side effects, such as a ... [more ▼]. Several grafting techniques and guided tissue regeneration techniques (GTR) have been well-developed in periodontal surgery. However, these techniques could induce pain and side effects, such as a gingival recession during the healing period following the therapy. The graft of a small autologous connective tissue, using non-invasive surgical techniques could yield several benefits for the patients. Our preliminary study explores the feasibility of collecting healthy gingival tissues, culturing them in vitro to amplify rat gingival fibroblasts (RGF) and inoculating the obtained cells into autologous rat gingival tissues in vivo. Gingival tissues samples were cultured as explants as described by Freshney et al. and Adolphe. ...
Objective: To investigate the contribution of cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) to PGE2 production in human gingival fibroblast cells stimulated with lipopolysaccharide from periodontopathogenic bacteria. Methods: Lipopolysaccharide was isolated from Porphyromonas gingivalis and Prevotella intermedia by the phenol-water method. Human gingival fibroblast cells were stimulated with lipopolysaccharide in different concentration for different time periods. The levels of PGE2 in the culture medium were measured by radioimmunoassay. The expression of COX-2 protein was observed by immunocytochemical staining; COX-1 and COX-2 mRNA expression were examined by semi-quantitative RT-PCR analysis. Results: The production of PGE2 in human gingival fibroblast cells was increased in a time- and dose-dependent manner (P < .01, P < .01). Immunocytochemical staining showed the positive expression of COX-2 protein in stimulated cells around the unstained cell nucleus, while no expression was ...
TY - JOUR. T1 - Gingival Fibroblasts as Autologous Feeders for Induced Pluripotent Stem Cells. AU - Yu, G.. AU - Okawa, H.. AU - Okita, K.. AU - Kamano, Y.. AU - Wang, F.. AU - Saeki, M.. AU - Yatani, H.. AU - Egusa, H.. PY - 2016/1/1. Y1 - 2016/1/1. N2 - Human gingival fibroblasts (hGFs) present an attractive source of induced pluripotent stem cells (iPSCs), which are expected to be a powerful tool for regenerative dentistry. However, problems to be addressed prior to clinical application include the use of animal-derived feeder cells for cultures. The aim of this study was to establish an autologous hGF-derived iPSC (hGF-iPSC) culture system by evaluating the feeder ability of hGFs. In both serum-containing and serum-free media, hGFs showed higher proliferation than human dermal fibroblasts (hDFs). Three hGF strains were isolated under serum-free conditions, although 2 showed impaired proliferation. When hGF-iPSCs were transferred onto mitomycin C-inactivated hGFs, hDFs, or mouse-derived SNL ...
C57BL/6-GFP Mouse Gingival Epithelial Cells from Creative Bioarray are isolated from C57BL/6-GFP-Tg(CAG-EGFP)1Osb/J mouse gingival tissue of pathogen-free laboratory mice. C57BL/6-GFP Mouse Gingival Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml and is delivered frozen. These cells are pre-coated with EpCAM-1 (CD326) antibody, following the application of magnetic beads pre-coated with secondary antibody Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
Hamster Gingival Epithelial Cells from Creative Bioarray are isolated from gingival tissue of pathogen-free laboratory mice. Hamster Gingival Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Creative Bioarrays Culture Complete Growth Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x10^6 cells per ml and is delivered frozen. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Creative Bioarray. Repeated freezing and thawing of cells is not recommended ...
Objective: Several local factors can affect the wound-healing process, delaying its progression and postponing tissue homeostasis. It is known that local inflammation is related to wound healing; however, the maintenance of the inflammatory reaction can impair the proliferation and migration of oral mucosal cells. The aim of this study was to evaluate the viability and chemokine expression of epithelial cells and gingival fibroblasts exposed to long-term lipopolysaccharide (LPS) treatment. Design: Epithelial cells (HaCaT, Cell Lines Service, 300493) and human gingival fibroblasts (HGFs) were seeded (1 105 cells/well) in 24-well plates and incubated for 24 h. To simulate the responses of cells to a local chronic oral mucosal inflammation, we added LPS of Escherichia coli (10 mg/ml) to Dulbeccos modified Eagles medium (DMEM), kept in contact with fibroblasts and epithelial cells for 24, 48, and 72 h. Then the cells were assessed for viability (alamarBlue assay), number (trypan blue assay), and ...
Periodontitis is a chronic inflammatory disease affecting the soft tissue and bone that surrounds the teeth. Despite extensive research, distinctive genes responsible for the disease have not been identified. The objective of this study was to elucidate transcriptome changes in periodontitis, by investigating gene expression profiles in gingival tissue obtained from periodontitis-affected and healthy gingiva from the same patient, using RNA-sequencing. Gingival biopsies were obtained from a disease-affected and a healthy site from each of 10 individuals diagnosed with periodontitis. Enrichment analysis performed among uniquely expressed genes for the periodontitis-affected and healthy tissues revealed several regulated pathways indicative of inflammation for the periodontitis-affected condition. Hierarchical clustering of the sequenced biopsies demonstrated clustering according to the degree of inflammation, as observed histologically in the biopsies, rather than clustering at the individual ...
Epithelial mesenchymal transition (EMT) has been implicated in neoplastic invasion and metastasis. We have previously generated six cell lines from human gingival mucosal keratinocytes immortalized by E6/E7 of human papillomavirus type 16. Ldk and NuB1 lines represented EMT phenotype and other four lines represented cobblestone non-EMT phenotype. These cell lines were utilized as model cells to determine whether inhibitors of apoptosis proteins and cell-cycle regulators were molecular players during EMT. EMT cells exhibited increased expression of vimentin, vascular endothelial growth factor (VEGF) receptor1 and the ability to form tubules on Matrigel as well as to grow anchorage independently. We found that EMT cells expressed significantly elevated levels of cIAP-1, Bclx and p27 kip higher than non-EMT cells. These proteins could therefore be used as intrinsic indicators of EMT of human gingival keratinocytes. © 2009 John Wiley & Sons A/S ...
Background and Aim: Previous studies have shown that some dyes used in photodynamic therapy (PDT) have a low pH and may cause root demineralization and remove the smear layer. This study aimed to assess and compare the effects of root biomodification with citric acid and PDT on the adhesion and proliferation ...
Fibroblasts are quality tested in FibroLife® S2 or FibroLife® Xeno-Free Medium to ensure proper growth and morphology for at least 15 population doublings.
Background: Evidences have shown that local anaesthetics are clinically useful compounds that exert a pharmacological effect by blocking nerve impulse propagation and also it is able to provoke proliferation and cell growth. Aims: The aim of this study w...
UCL Discovery is UCLs open access repository, showcasing and providing access to UCL research outputs from all UCL disciplines.
Direct bonding of orthodontic brackets is an established procedure and has lead to increasing number of light-cured bonding materials produced with ever-increasing bond strength and ease of delivery. However, considerably less attention is given to biocompatibility of these materials. Both in vivo and in vitro studies indicate orthodontic bonding agents are cytotoxic. Spectrophotometric analysis revealed that these resins contained a great amount of potentially toxic, leachable, un-polymerized material, even when fully cured. Hypothesis: Different light-cured bonding agents may have different cytotoxic effects depending on their chemistry. Objective: Compare and analyze the toxicity of three different light-cured bonding agents to a population of gingival cells as measured by cell growth, and viability in vitro. Method: Light Bond®, MonoLok®, and Transbond XT® orthodontic adhesives were tested. Human gingival cells were obtained from extracted third molars, pooled, and expanded until needed. ...
THEODORE ROSETT, PAMELA S. GARNER, and LOUIS P. GANGAROSA Department of Biochemistry, Temple University School of Dentistry, Philadelphia, Pennsylvania, 19140, USA and Department of Oral Biology, Medical College of Georgia, Augusta, Georgia J Dent Res May-June 1972, Vol 51 No. 3 Previous studies (RoSETT ET AL, J Dent Res 50:161, 1971; GANGAROSA and ROSETT, J Dent Res 50:163, 1971) and the present one aim to determine physiologic and metabolic processes in human gingival tissue to discover how these processes are altered during the induction of periodontal disease. We chose cattle gingival epithelium to have a readily available supply of tissues. In this study we investigated the normal levels of some enzymes involved in glucose metabolism within bovine attached gingival epithelium. In determining the relative levels of the enzyme in any particular series of metabolic pathways, it is emphasized that we are only reporting the potential for conversion of substrate to product. The existence of these ...
Dental professionals are well positioned to educate patients about the overall health implications of chronic inflammation, particularly relating to periodontal disease. A greater understanding of the role of inflammation in various seemingly unrelated conditions allows practitioners to provide alternative strategies for prevention while resolving inflammation to reduce the risk of various systemic conditions.2. Periodontitis occurs when bacteria trigger inflammation with the release of various biochemical mediators, such as cytokines, which may lead to the destruction of gingival connective tissue and bone.3 Chronic adult periodontitis is the common form of this bacterially induced inflammatory disease, which affects a substantial number of adults and has shown to be a significant contributing factor to other systemic conditions.4 Chronic diseases such as atherosclerotic cardiovascular disease, rheumatoid arthritis, and diabetes mellitus may develop or worsen in part due to uncontrolled ...
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TY - JOUR. T1 - Biofilm-stimulated epithelium modulates the inflammatory responses in co-cultured immune cells. AU - Brown, Jason L.. AU - Johnston, William. AU - Delaney, Chris. AU - Rajendran, Ranjith AU - Butcher, John. AU - Khan, Shaz. AU - Bradshaw, David. AU - Ramage, Gordon. AU - Culshaw, Shauna. N1 - Acceptance from webpage OA article. PY - 2019/10/31. Y1 - 2019/10/31. N2 - The gingival epithelium is a physical and immunological barrier to the microbiota of the oral cavity, which interact through soluble mediators with the immune cells that patrol the tissue at the gingival epithelium. We sought to develop a three-dimensional gingivae-biofilm interface model using a commercially available gingival epithelium to study the tissue inflammatory response to oral biofilms associated with health, gingivitis and periodontitis.. These biofilms were developed by sequential addition of microorganisms to mimic the formation of supra- and sub-gingival plaque in vivo. Secondly, to mimic the ...
Nadine Krockow. The aim of this literature review was to define the most favorable surface topography and macrodesign of the transmucosal zone of abutments to achieve optimal soft tissue seal. A search identified 12 articles-3 human studies, 3 animal studies, and 6 in vitro studies-meeting the inclusion criteria for final evaluation. The human histologic studies showed that laser-ablated, hydrophilic, and oxidized titanium surfaces result in perpendicular insertion of human gingival fibroblasts into the treated abutment surface. Epithelial cells seem to slightly favor zirconia and polished titanium surfaces.. 2018 January/February; 66(1):18-25. ...
Titanium tetrafluoride solutions: occlusion of dentinal tubules and citotoxicity on gingival fibroblasts. Scholarships in Brazil Scientific Initiation. Eliza Maximiano Cury. Health Sciences
409 Role of Neutrophils in Periodontal Disease 051205_lecture32 Artigo DENGUE In Adv Nutr 2011 Wallace 1 7 Osteoarthritis Interleukin-6 and Tumor Necrosis Factor-A Production After Acute Psychological Cytotoxicity of Resin Monomers on Human Gingival Fib Rob Lasts and HaCaT Keratinocytes Cell Communication Biology Tooth Movement Interluekin The Effects of Ursolic Acid on Cytokine Production Sepsis.pptx
The keratinized oral gingival epithelium provides effective protection against both mechanical trauma and bacterial invasion. The horny cell layer acts like a film of plastic wrap, allowing the body to retain moisture and protecting it from invasion by foreign substances and comprises various substances such as keratins, produced by the epidermal keratinocytes and lipids. The epidermal keratinocytes divide in the basal layer, produce keratins and differentiate, and migrate to the upper layers as they mature by a process called keratinization. The present review discusses the structure of keratin, the process of keratinization and their distribution in gingival epithelium.. ...
This study indicates that the deficient immunomodulatory function of iGMSCs could be rescued by ASA pretreatment via upregulating of FasL in mice. This strategy might serve as a practical approach to rescue deficient MSC function for further therapeutic application.
Advanced search is divided into two main parts, and one or more groups in each of the main parts. The main parts are the Search for (including) and the Remove from search (excluding) part. (The excluding part might not be visible until you hit NOT for the first time ...
Principal Investigator:SAITO Kihachi, Project Period (FY):1989 - 1990, Research Category:Grant-in-Aid for General Scientific Research (C), Research Field:Functional basic dentistry
Affiliation:愛知学院大学,歯学部,講師, Research Field:矯正・小児・社会系歯学,小児・社会系歯学, Keywords:歯周疾患,小児,細胞増殖能,b-FGF,サイトカイン,PDGF-AB,Down Syndrome,gingival fibroblasts,growth activity,歯肉線維芽細胞, # of Research Projects:7, # of Research Products:0
Dont take Seretide without checking for Side Effects | A female patient was diagnosed with asthma, gingival disorder, treated with SERETIDE and reported asthmatic crisis,gingival disorder,gingival pain. Dosage: .
Learn about the causes, symptoms, diagnosis & treatment of Periodontal Disorders from the Professional Version of the Merck Manuals.
TY - JOUR. T1 - Calcium phosphate particles induce interleukin-8 expression in a human gingival epithelial cell line via the nuclear factor-κB signaling pathway. AU - Sakai, Yu. AU - Nemoto, Eiji. AU - Kanaya, Sousuke. AU - Shimonishi, Mitsuru. AU - Shimauchi, Hidetoshi. PY - 2014/10/1. Y1 - 2014/10/1. N2 - Background: Dental calculus is calcified plaque composed primarily of calcium phosphate mineral salts, and there is a clear association between the presence of calculus and the initiation/progression of periodontitis. However, it is still inconclusive whether dental calculus can be a direct causative factor. The authors examined the effect of nano/microsized calcium phosphate particles, which may be generated in the process of early precipitation and/or dissolution of calcium phosphate mineral, on the expression of interleukin (IL)-8 in human gingival epithelial cells. Methods: Primary human gingival epithelial cells and/or a human gingival carcinoma cell line (Ca9-22) were stimulated with ...
TY - JOUR. T1 - Human gingival fibroblast feeder cells promote maturation of induced pluripotent stem cells into cardiomyocytes. AU - Matsuda, Yusuke. AU - Takahashi, Ken. AU - Kamioka, Hiroshi. AU - Naruse, Keiji. PY - 2018/9/10. Y1 - 2018/9/10. N2 - The use of human induced pluripotent stem (iPS) cells has been investigated in multiple regenerative medicine studies. However, although methods for efficient differentiation of iPS cells into heart tissues have been devised, it remains difficult to obtain cardiac tissue with high contractility. Herein, we established a method for differentiating iPS cells into highly contractile cardiomyocytes (CMs), and demonstrate that the use of human gingival fibroblasts (HGFs) as a feeder cells promotes maturation of iPS-derived CMs (iPS-CMs) in vitro. After CM differentiation of iPS cells, iPS-CMs showed increased mRNA expression of the CM specific maker cardiac troponin T (cTnT) in the absence and presence (on-feeder condition) of cocultured HGFs, and ...
Shikonin, an active ingredient of Lithospermum erythrorhizon, exerts anti-inflammatory and antibacterial effects, and promotes wound healing. We investigated whether shikonin stimulated gingival tissue wound healing in human gingival fibroblasts (hGF). In addition, we evaluated the effects of shikonin on the mitogen-activated protein kinase (MAPK) signaling pathway, which has an important role in wound healing. hGF were subjected to primary culture using gingiva collected from patients. The cells were exposed to/treated with Shikonin at concentrations ranging from 0.01 to 100 μM. The optimal concentration was determined by cell proliferation and migration assays. Type I collagen and fibronectin synthesis, the gene expression of vascular endothelial growth factor (VEGF) and FN, and the phosphorylation of Extracellular signal-regulated kinase (ERK) 1/2 were investigated. Identical experiments were performed in the presence of PD98059 our data suggest, a specific ERK 1/2 inhibitor. Shikonin
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Two novel proteins - odontogenic ameloblast-associated protein and amelotin - have recently been identified in maturation-stage ameloblasts and in the junctional epithelium. This article reviews the structure and function of the junctional epithelium, the pattern of expression of odontogenic ameloblast-associated and amelotin proteins and the potential involvement of these proteins in the formation and regeneration of the junctional epithelium. ...
Porphyromonas gingivalis, a periodontal pathogen, can invade primary cultures of gingival epithelial cells. Optimal invasion occurred at a relatively low multiplicity of infection (i.e., 100) and demonstrated saturation at a higher multiplicity of infection. Following the lag phase, during which bacteria invaded poorly, invasion was independent of growth phase. P. gingivalis was capable of replicating within the epithelial cells. Invasion was an active process requiring both bacterial and epithelial cell energy production. Invasion was sensitive to inhibitors of microfilaments and microtubules, demonstrating that epithelial cell cytoskeletal rearrangements are involved in bacterial entry. P. gingivalis, but not epithelial cell, protein synthesis was necessary for invasion. Invasion within the epithelial cells was not blocked by inhibitors of protein kinase activity. Invasion was inhibited by protease inhibitors, suggesting that P. gingivalis proteases may be involved in the invasion process. ...
OBJECTIVES The purpose of the present study was to analyse transcriptomes and mRNA expression levels for specific genes in calcium-channel blocker-induced gingival overgrowth (GO) tissues. DESIGN Eight gingival tissues samples (from both GO negative and positive sites) were harvested from four GO patients for microarray analyses. Twelve candidate genes were selected for further quantitative real time reverse transcription-polymerase chain reaction (qRT-PCR) analyses. Ten GO tissues from periodontitis patients and ten control gingival tissues from healthy subjects were compared by qRT-PCR. Mann-Whitney U-test was used for statistical evaluation. RESULTS In GO positive tissues, 163-1631 up-regulated and 100-695 down-regulated genes were identified with more than two-fold changes compared with GO negative tissues amongst patients by microarray experiments. No commonly expressed genes amongst the eight sets of microarray data were found. The clustering analysis confirmed that the entire transcriptome
Monkey periodontal ligament fibroblasts (MPLF cells), human gingival fibroblasts (HGF cells), rat embryonic calvaria cells (REC cells), porcine periodontal ligament epithelial cells (PPLE cells) and rat osteosarcoma 17/2 cells (ROS cells) were incorporated into 3-dimensional collagen gels plated in 60 mm Petri dishes in order: first, to measure the capacity of these cell types to contract; second, to investigate cell-collagen and intercellular relationships during contraction; and third, to define the cellular contribution to tissue contraction in an in vitro system. Measurements at times up to 72 h on 3 ml gels containing 5 × 10(5) cells and with a collagen concentration of 1.20 mg/ml showed that MPLF cells contracted the gels at a significantly greater rate (P less than 0.001) than did the other cell types. In addition, contraction started sooner and was of greater extent than with the other cells. HGF cells contracted the gels more rapidly than REC and PPLE cells, while ROS cells caused no ...
Background: Root surface debridement (RSD) is necessary to create an environment suitable for reattachment of the periodontium. Root surface conditioning may aid the formation of a biocompatible surface suitable for cell reattachment. BioPure™ MTAD (mixture of Doxycycline, citric acid and a detergent) is an endodontic irrigant with antibacterial properties and the ability to remove smear layer. It was hypothesized that MTAD may be useful for root surface conditioning. The efficacy of MTAD as a conditioner was measured by examining fibroblast attachment to root surfaces. Materials and Methods: Thirty-two specimens of human teeth with advanced periodontal disease were used. The surfaces were root planed until smooth. Half of the specimens were treated with 0.9% saline and the other samples with Biopure MTAD. As a negative control group, five further samples were left unscaled with surface calculus. Human gingival fibroblast cells HGF1-PI1 were cultured and poured over the tooth specimens and ...
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis ...
Gingival And Periodontal Pocket. Gingival and periodontal pockets are dental terms indicating the presence of an abnormal gingival sulcus near the point at which the gums contact a tooth. ...
Arlington Heights oral surgeon, Dr. Khan recommends gingival graft if a build-up of calculus and plaque on the root or if tooth decay has already started.
In the most drastic stage of periodontal disease, the bone and the attachment of the gums to the teeth have been destroyed. This may cause your teeth to shift or loosen and can affect how your teeth come together. You may notice a bad taste or smell in your mouth. Proper dental care must be initiated to save the teeth or they may need to be removed. Professional intervention may involve pocket reduction therapy and bone grafting along with the incorporation of other therapies.. Pocket reduction therapy is required for this form of periodontal disease when the gingival tissues have not resolved after initial treatment or tissue and root therapy. This is usually necessary when gingival tissues have not shrunk enough or when the supporting bone around the teeth has been lost. Since the gum tissue has not shrunk, they provide a greater place for bacteria to live and attack the bone and tissue causing further damage to occur.. Pocket reduction is a periodontal disease therapy that turns or pulls back ...
Periodontitis is a chronic destructive category of periodontal disease that progresses to the resorption of alveolar bone, which leads to progressive bone destruction and tooth loss. As a consequence of resorption, breakdown of products are released into periodontal tissues, migrating toward the gingival sulcus and gathering from the surrounding site in whole saliva, where several of them have been identified. 2930. Among the several host enzymes proposed as diagnostic indicators of periodontal status, ALP was one of the first to be identified. 31 ALP is released from polymorphonuclear cells (PMNs) during inflammation 10 and from osteoblasts 32 and periodontal ligament fibroblasts 33 during bone formation and periodontal regeneration respectively.. ALP activity in serum has been extensively studied, and it was suggested that ALP allows bone mineralization by releasing an organic phosphate that contributes to the deposition of calcium phosphate complexes into the osteoid matrix. 3435 ALP might ...
Quickly simulate missing gingival tissue with Renamel Gingafill. This pink composite is easily placed, readily sculptable and highly polishable. Renamel Gingafill is a great solution for lost gingival tissue, cervical erosions with loss of gingival attachment and reconstruction of lost inter-dental papilla ...
Periodontal disease occurs when bacteria from the mouth form on the pets teeth in a substance called plaque. The plaque makes its way under the gumline and sets in motion a vicious circle, which can eventually lead to tooth loss for the animal. The bacteria in the subgingival plaque will secrete toxins. These toxins damage the periodontal tissues and can decrease the attachment.. However, the bacteria will also elicit an inflammatory response from the animals gingival tissues. White blood cells and other inflammatory mediators will leak out of the periodontal tissues and into the periodontal space (between the gum or bone and the tooth). The white blood cells will release their enzymes to destroy the bacterial invaders, but will also damage the attachment of the tooth. As this progresses, the pocket will get deeper and deeper. This will weaken the bone in the area, and if it is in the lower jaw it can weaken it to the point of causing a pathologic fracture. This is most common in older small ...
Site-Wise Analysis concluded that adding LISTERINE® Antiseptic result-ed in 2x more healthy gingival sites versus brushing and flossing alone.
An item used for retraction of gingival tissues in preparation for taking impressions and setting of crowns or restorations. It controls the bleeding and seepage of tissues during dental procedures. ...
Periodontitis, an inflammatory disease that affects the tissues surrounding the teeth, is a common disease worldwide. It is caused by a dysregulation of the host inflammatory response to bacterial infection, which leads to soft and hard tissue destruction. In particular, it is the excessive inflammation in response to bacterial plaque that leads to the release of reactive oxygen species (ROS) from neutrophils, which, then play a critical role in the destruction of periodontal tissue.Generally, ROS produced from immune cells exhibit an anti-bacterial effect and play a role in host defense and immune regulation. Excessive ROS, however, can exert cytotoxic effects, cause oxidative damage to proteins and DNA, can interfere with cell growth and cell cycle progression, and induce apoptosis of gingival fibroblasts. Collectively, these effects enable ROS to directly induce periodontal tissue damage. Some ROS also act as intracellular signaling molecules during osteoclastogenesis, and can thus also play an
There are some limitations to using cadaver tissue, but it can be done. The laser aids in faster healing. There are no set rules with regard to millimeters.
Gingival biopsies were obtained from 23 children, aged 5-11 years (8.6 ± 1.8 years). Specimens were taken from areas of the gingiva adjacent to the teeth which were to be extracted because of caries or its sequelae and ...
A 62 y/o female presented with a very large gingival swelling. She stated that the swelling had been of about 3 months duration. The gingival swelling was in the area of retained roots of tooth 25 measuring 4.2 x 3.4 x 3.7 cm. The patient reported that this swelling impaired her ability to close her mouth and impacted eating but that she was otherwise asymptomatic. There was no pain, bleeding or sensitivity associated with the swelling.
The P12 Biofilm Left is a left curved insert with a circular surface and rounded tip. It is recommended for subgingival biofilm removal. Compatibility & T
The P10 Biofilm Straight is a long insert with a circular surface and rounded tip. It is recommended for subgingival biofilm removal. Power Settings: 20% Compat
A study to assess the effectiveness of Video Assisted Teaching (vat) programme on knowledge regarding management of minor disorders of newborn among primipara mothers in selected phc, Bangalore. Gingival cyst of the newborn ...
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Nous avons établi une technique pour lisolement, la caractérisation phénotypique et lanalyse fonctionnelle des cellules...
ATCC has a large collection of cell lines derived from skin, representing the normal and diseased tissue of multiple species.
ATCC has a large collection of cell lines derived from skin, representing the normal and diseased tissue of multiple species.
Gingiva • Gingival and periodontal pockets • Gingival cyst of the adult • Gingival cyst of the newborn • Gingival enlargement ...
In the epithelium of the mouth, the attached gingiva exhibit rete pegs, while the sulcular and junctional epithelia do not. ... Itoiz, ME; Carranza, FA: The Gingiva. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical Periodontology, 9th ...
... fibers that extend towards the crest of the gingiva fibers that extend laterally to the outer surface of the gingiva and fibers ... They hold the marginal gingiva against the tooth They provide the marginal gingiva with enough rigidity to withstand the forces ... circular group - these fibers are unique in that they exist entirely within the gingiva and do not contact the tooth ... Itoiz, ME; Carranza, FA: The Gingiva. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical Periodontology, 9th ...
The gingiva often possess a textured surface that is referred to as being stippled (engraved points). Stippling only presents ... Stippling used to be thought to indicate health, but it has since been shown that smooth gingiva is not an indication of ... Itoiz, ME; Carranza, FA: The Gingiva. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical Periodontology, 9th ... on the attached gingiva bound to underlying alveolar bone, not the freely moveable alveolar mucosa. ...
Itoiz, ME; Carranza, FA: The Gingiva. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranza's Clinical Periodontology, 9th ...
Nodular fasciitis Inflammatory fibroid polyp Manohar, B.; Bhuvaneshwari, S. (Jan 2011). "Plasma cell granuloma of gingiva". J ...
"Pulsed laser beam effects on gingiva". Journal of Clinical Periodontology. 21 (6): 391-396. doi:10.1111/j.1600-051X.1994. ...
The periodontium consists of four tissues: gingiva, or gum tissue, cementum, or outer layer of the roots of teeth, alveolar ... Crich, Aubrey (1932). "Blastomycosis of the gingiva and jaw". Can Med Assoc J. 26 (6): 662-65. PMC 402380 . PMID 20318753. ...
Holding the gingiva under definite tension. In case of under-developed curvature, gingival recession may result. In case of ... have great functions to oral cavity They allow the food to be deflected allowing proper degree of massage to the gingiva. They ... overdeveloped curvature, food will accumulate and there will be no massage to the gingiva and chronic inflammation may result. ...
It is most often seen in the lower labial gingiva of tobacco users. Most easily it is found in Caucasians, due to their lack of ... Hanioka T, Tanaka K, Ojima M, Yuuki K: Association of melanin pigmentation in the gingiva of children with parents who smoke. ... Occurrence and localization in the attached gingiva. Arch Dermatol 1977; 113:1533-1538. Hedin CA, Larsson Å: The ultrastructure ... Dose-Response relationship between tobacco consumption and melanin pigmentation in the attached gingiva. Arch Environ Health ...
They may remain completely underneath the gingiva. A good rule that holds true in most cases is: The further forward or rostral ...
Lesions are located on the buccal mucosa (inside of the cheeks) or on the gingiva (gums). The condition resembles Oral lichen ... Cheilitis, glossitis, gingivitis syndrome; atypical gingivostomatitis, plasma-cell gingivitis, plasmacytosis of gingiva". Oral ...
Following laser depigmentation, the gingiva heals by secondary intention. This results in a lighter and more uniform color of ...
A gingival abscess involves only the gingiva near the marginal gingiva or the interdental papilla. A periodontal abscess ... The early lesion can occupy up to 15% of the connective tissue of the marginal gingiva and up to 60-70% of collagen may be ... Attström R, Graf-de Beer M, Schroeder HE (July 1975). "Clinical and histologic characteristics of normal gingiva in dogs". J. ... Generally all gingival diseases share common features such as signs and symptoms being restricted to gingiva, clinically ...
Interactions between the gingiva and the margin of restorations. J Clin Perio 2003;30:379-385. Galen WW, Mueller KI: ... chronic pain chronic inflammation of the gingiva unpredictable loss of alveolar bone In addition to crown lengthening to ...
... desquamative gingivitis extends beyond the marginal gingiva, involving the full width of the gingiva and sometimes the alveolar ... Plasma cell gingivitis is another form of gingivitis which affects both the attached and free gingiva. Caused by various ... Desquamative gingivitis involves lesions of the free and attached gingiva. Unlike plaque-induced inflammation of the gums ( ...
The gingiva ("gums") is the mucosal tissue that overlays the jaws. There are three different types of epithelium associated ... It consists of the cementum, periodontal ligaments, alveolar bone, and gingiva. Of these, cementum is the only one that is a ... Long term use of chlorhexidine, a mouthwash, may encourage extrinsic stain formation near the gingiva on teeth. This is usually ... The sulcular epithelium is nonkeratinized stratified squamous tissue on the gingiva which touches but is not attached to the ...
The most common oral locations are on the gingiva of the mandible, tongue, and palate. It is a localized reactive proliferation ... The most predominant location is the mandibular gingiva (Houston, 1982; Bakos, 1992). Histologically, the GCF is distinctive, ...
Halhoul, N.; Colvin, J.Ross (1975). "The ultrastructure of bacterial plaque attached to the gingiva of man". Archives of Oral ...
"Traditional Tattooing of the Gingiva: Successful Treatment with the Argon Laser". Archives of Dermatology. 126 (4): 547-8. doi: ...
Kertinocytes can be isolated from different areas of the oral cavity (such as the palate or gingiva). It is important that the ... Keratinized squamous epithelium is present in the gingiva and hard palate. Keratinization is the differentiation of ...
De Impetigine De iis quae Gingivae Dentibusque accidunt. De iis qui Medico destituuntur. De Morborum Indiciis De Arthritidis ...
Small OACs can be closed by suturing the gingiva over the defect. A soft tissue flap is required when suturing is not able to ...
When the gingiva are swollen, the epithelial lining of the gingival crevice becomes ulcerated and the gums will bleed more ... If gingivitis is not responsive to treatment, referral to a periodontist (a specialist in diseases of the gingiva and bone ... This inflammation can cause an enlargement of the gingiva and subsequent formation. Early plaque in health consists of a ... The comprehensive periodontal exam consists of a visual exam, a series of radiographs, probing of the gingiva, determining the ...
The patient's jaw may also appear distorted because of the gingiva englargements. Overgrowth of the gingiva can range from ... Although, enlargement of gingiva, interdental papilla, hindered speech, and secondary inflammatory changes taking place in the ... The following can occur if left untreated: Too much gingiva exposure Oral morbidity Chronic infection of areas between the gums ... HGF is characterized as a benign, slowly progressive, nonhemorrhagic, fibrous enlargement of keratinized gingiva. It can cover ...
Healthy gingiva consists of few microorganisms, mostly coccoid cells and straight rods. Diseased gingiva consists of increased ... Clinical signs of periodontal pockets include bluish-red, thickened gingiva, gingival bleeding, localized pain and in some ... it is defined as the apical extension of the gingiva, resulting in detachment of the periodontal ligament (PDL). The PDL is a ...
They form spillways between teeth to direct food away from the gingiva. Also, they provide a mechanism for teeth to be more ... The borders of embrasures are formed by the interdental papilla of the gingiva, the adjacent teeth, and the contact point where ... The cervical embrasure usually is filled by the interdental papilla from the gingiva; in the absence of adequate gingival ... Lastly, they protect the gingiva from undue frictional trauma but also providing the proper degree of stimulation to the ...
The gingiva covers the alveolar processes, the tooth-bearing arches of the jaws. Enamel is not a vital tissue, as it lacks ... In the mouth, the soft tissues of the gingiva, mucosa, tongue, and pharynx are examined for redness, swelling or deformity. ... first with debridement of the necrotic gingiva, homecare with hydrogen peroxide mouthwash, analgesics and, when the pain has ...
This procedure is followed to create physiological gingival contours with the sole purpose of recontouring the gingiva in the ... Gingival and periodontal disease often produces deformities in the gingiva that are conducive to the accumulation of plaque and ... Gingivoplasty is the process by which the gingiva are reshaped to correct deformities. Gingivoplasty is similar to gingivectomy ... thinning the attached gingiva, creating the vertical interdental grooves and shaping the interdental papillae. Barrington, ...
Chronic gingiva inflammation can be a difficult to treat medical problem in dogs. A similar anti-inflammatory effect was ... After 30 and 45 days, the dogs using the adelmidrol gel had significantly less inflammation of the gingiva. Furthermore, the ...
Gingiva • Gingival and periodontal pockets • Gingival cyst of the adult • Gingival cyst of the newborn • Gingival enlargement ...
In the epithelium of the mouth, the attached gingiva exhibit rete pegs, while the sulcular and junctional epithelia do not. ... Itoiz, ME; Carranza, FA: The Gingiva. In Newman, MG; Takei, HH; Carranza, FA; editors: Carranzas Clinical Periodontology, 9th ...
The most common location for a fibrosarcoma of the the mouth is in the gums (gingiva). ...
Tag Archives: marginal gingiva Types of Mandibular Major Connectors Part 2 Leave a reply ... A 1 mm concavity for the base of the pontic, further apical to the maximal curvature of the adjacent marginal gingiva, is ... Unlike plaque-induced inflammation it is a dusky red colour and extends beyond the marginal gingiva, often to the full width of ... marginal gingiva, prosthetic teeth, removable partial denture on June 21, 2012. by chzechze. Types of pontic Part 2 Leave a ...
A shallow line or indentation is found on the surface of the gingiva that spllits the free gingiva via the attached gingiva is ... Connected Gingiva. *It is the section of the gingiva that extends to the top via the area of the free gingival groove towards ... Marginal (Free) Gingiva. *This part of the gingiva envelops the neck of the tooth and is not directly connected to the tooth ... Keratinized Gingiva. *The band of keratinized gingiva expands via the gingival margin to the mucogingival junction. ...
Beautifil II Gingiva Syringe G-Or Refill 2.5g. SKU: 300-Y2260 ... Beautifil II Gingiva Syringe G-Br Refill 2.5g. SKU: 300-Y2259 ... Beautifil II Gingiva Syringe G-V Refill 2.5g. SKU: 300-Y2258 ... Beautifil II Gingiva Syringe G-DP Refill 2.5g. SKU: 300-Y2257 ... Beautifil II Gingiva Syringe G-LP Refill 2.5g. SKU: 300-Y2256 ... Products Cosmetic Dentistry Composites Beautifil II Gingiva ...
I T, Miura KI, Kakehashi H, Shiraishi T, Egashira K, Asahina I. Carcinoma cuniculatum of the lower gingiva masked with ... I, T, Miura, KI, Kakehashi, H, Shiraishi, T, Egashira, K & Asahina, I 2021, Carcinoma cuniculatum of the lower gingiva masked ... Carcinoma cuniculatum of the lower gingiva masked with leukoplakia : A case of difficult diagnosis. In: Journal of Oral and ... Fingerprint Dive into the research topics of Carcinoma cuniculatum of the lower gingiva masked with leukoplakia: A case of ...
Intraorally, the most common sites are the palate and gingiva followed by mandibular gingiva and lip mucosa. Oral melanoma is ... Figure 1: Intraorally, a blackish exophytic growth in the left side maxillary gingiva. Click here to view. ... Primary mucosal melanoma of maxillary gingiva with metastasis: A rare case report with brief review of literature. Jimsha ... Kumaran JV, Daniel MJ, Krishnan M, Seetharaman D. Primary mucosal melanoma of maxillary gingiva with metastasis: A rare case ...
Conclusions: the study shows that NI can be induced in human gingiva, and such evidence could be extremely important in the ...
Design implant-supported bridges with gingiva parts in record time ... Study identifies asymptomatic state of gingivae that links gingivitis, periodontitis and ageing ... of time when creating implant-supported bridges with gingiva parts. An unparalleled variety of materials and options is ...
Gingivitis: Gingivitis is a chronic inflammation of the gum tissue (gingiva). Typically associated with poor oral hygiene, ...
Buyamag teaching ortho braces model practicing with manikin ligature tying, cuspid teeth. Study orthodontic retainers brackets, wires.
Hard plastic gingiva with molded-in plastic teeth. Fully flossable with full interproximal contacts. Simple clear ... ...
The gingiva is often red, inflammed and edematous (swollen).. Treatment for alveolar osteitis. ...
Gingiva Mask. NextDent for Ceramill Gingiva Mask Matériau pour fausses gencives Imprimante 3D ...
Gingiva Mask. NextDent for Ceramill Gingiva Mask 3D print material for gingival masks ...
Gingiva Mask. NextDent for Ceramill Gingiva Mask Matériau pour fausses gencives Imprimante 3D ...
FenderWedge Prep - Schützt Zähne und Gingiva während der Präparation von Kronen und Veneers ...
Gingivitis is an inflammation of the gums that commonly occurs as a result of plaque buildup on the teeth and gingiva. Plaque ...
Fifty-one patients with varying conditions of the gingiva were divided into two groups.. The study group received the ...
This gingiva is then attached to the area of the gum that is receding. Underneath the surface, new cells are working hard to ... Once you are comfortable, and your periodontist is sure you wont feel any pain, the gingiva to be grafted is harvested either ...
... and gingiva, while milk debris is limited to the tongue; and (3) oral Candida is rather adherent to an involved skin surface ... gingiva). While it is most commonly seen in young infants, thrush may affect toddlers, and to a lesser degree, older children ...
Raih Juara 1 Konferensi Internasional Berkat Penelitian Metabolit Sel Punca Mesenkimal Gingiva https://t.co/2uskijoIhQ ...
Raih Juara 1 Konferensi Internasional Berkat Penelitian Metabolit Sel Punca Mesenkimal Gingiva https://t.co/2uskijoIhQ ...
6. Periodontitis: Periodontitis is a chronic inflammatory disease of the gingiva and is a risk factor for development of ...
Gingiva means the gum, which is the area around the root of a gingiva is. A ... What is gingivectomy: The term gingivectomy means excision of gingiva (Gingiva means the gum, which is the area around the root ... Oral hygiene maintain and periodontal pack replacement: Advertisement The term gingivectomy means excision of gingiva Gingiva ... Resection of the gingiva. The curettage is guided along the tooth surface and under the granulation tissue, so that it is ...
Burton line - a bluish line on the free border of the gingiva, occurring in lead poisoning. Synonym(s): lead line ...
After irrigation gingiva closed w monocryl, dog blowing bubbles through one nostril but otherwise recovered well. ...
Possible complications include recurrence of gingivitis, periodontitis, trench mouth, or an infection of the gingiva or jaw ...
Prosthetic Gingival Reconstruction in a Fixed Partial Restoration - Part 1: Introduction to Artificial Gingiva as an ...
Clapton line - a greenish discoloration of the marginal gingiva in cases of chronic copper poisoning. ...
  • The supporting tissues are known as the periodontium , which includes the gingiva (gums), alveolar bone , cementum , and the periodontal ligament . (wikipedia.org)
  • Gingiva is another word for the gums, or the soft, pink tissue that surrounds and protects the bottom of the teeth where they enter the jawbone. (icoi.org)
  • A:Gingiva is the dental term for gums. (dentalqa.com)
  • The present study reported a patient with LRPLN metastasis from squamous cell carcinoma of the upper gingiva, who survived for >7 years. (spandidos-publications.com)
  • Alexander Pazoki, D.D.S.,M.D.,F.A.C.S., Director of the Johns Hopkins Division of Oral and Maxillofacial Surgery and Dentistry, and Assistant Professor of Otolaryngology-Head and Neck Surgery, presents the case of a 68-year-old male with squamous cell carcinoma of the left mandible gingiva. (hopkinsmedicine.org)
  • Pada gingiva selama kehamilan (Pregnancy gingivitis). (scribd.com)
  • Photos courtesy of Dr. Jan Bellows) Gingivitis, or inflammation of the gingiva, is the most common disease in dogs and cats. (dvm360.com)
  • Gingivitis is an infectious inflammation of the gingiva that is caused by the long-term effects of plaque, a bacterial colonization of the teeth and the gingiva. (priaid.ch)
  • Gingivitis is an infectious inflammation occurring in the gingiva. (priaid.ch)
  • Gingivitis is normally the long-term effect of plaque, a bacterially colonized biofilm deposited on the teeth and the gingiva. (priaid.ch)
  • In the presence of gingivitis, people often have symptoms such as bad oral odor and swelling, redness, ulcerations and bleeding on the gingiva. (priaid.ch)
  • The following report is another case of bilateral symmetrical lymphangioma of the gingiva which occurred in anterior maxillary gingiva as areas of hyperplastic gingivitis. (biomedcentral.com)
  • The presence of gingivitis increases this risk by making the gingiva more likely to bleed with simple manipulation (eg, dental scaling). (medscape.com)
  • The width of the attached gingiva varies in different areas of the mouth and is widest at the maxillary canines (Figures 3A and 3B). (dvm360.com)
  • The gingival margin of the tooth, therefore the entire dentogingival complex, moves coronally with a resulting increase in width of the attached gingiva. (dentaldevotee.com)
  • The inner surface (next to the tooth) of the free gingiva forms the gingival wall of the sulcus. (dvm360.com)
  • The attached gingiva extends apically from the free gingiva to the alveolar mucosa. (dvm360.com)
  • The tissues that sit above the alveolar bone crest are considered the free gingiva. (wikipedia.org)
  • A natural space called the gingival sulcus lies apically to the gingival margin, between the tooth and the free gingiva. (wikipedia.org)
  • [4] [5] The middle or centre part of the interdental papilla is made up of attached gingiva, whereas the borders and tip are formed by the free gingiva. (wikipedia.org)
  • Metastatic lung malignancy to mandibular gingiva. (bvsalud.org)
  • Lymphangioma of the gingiva is a rare lesion that manifest as a pebbly hyperplasia on gingiva. (biomedcentral.com)
  • Bilateral lymphangioma of the gingiva is a very rare lesion which its origin is controversial. (biomedcentral.com)
  • This model was obtained through a method of low density seeding epithelialization, from a seeding made up of dissociated human gingiva epithelial cells, of a connective tissue equivalent composed of human fibroblasts included in a collagen gel. (meta.org)
  • Even though this model has less of a differentiation than that of an in vivo gingival epithelium, it does actually reproduce exactly the structures of the human gingiva namely a multilayered epithelium lying on a connective tissue. (meta.org)
  • Some histological and histochemical observations on the connective tissue of chronically inflamed human gingiva. (semanticscholar.org)
  • The suitable cleaning of the oral cavity and within it firstly the teeth and the gingiva is a problem equal in age with the humanity since the failure of the oral hygiene can be accompanied with pain and suffering as well as with digestive anomalies. (google.com)
  • that portion of the gingiva that covers the buccal surfaces of the teeth and alveolar process. (thefreedictionary.com)
  • Peripheral manifestation include the canine area and buccal gingiva around the canine area. (thefreedictionary.com)
  • On intra oral examination there was a solitary swelling with ill-defined borders of size 5x4 centimeter was noted on the right buccal gingiva extending from mesial aspect of 14 to distal aspect of 17 (Figure 2). (thefreedictionary.com)
  • The microscopic analysis was performed on the buccal gingiva of the mandibular right first molar by a single calibrated blind examiner using a light transmission microscope BX51 (Olympus, Melville, NY, USA). (thefreedictionary.com)
  • The palatal and buccal gingiva of the upper anterior region was sutured into position. (thefreedictionary.com)
  • A 39-year-old male patient presented with a fibrous mass on the attached buccal gingiva of the upper left cuspid teeth. (biomedcentral.com)
  • A fibrous mass on the attached buccal gingiva of the upper left cuspid teeth was seen during the clinical intraoral examination. (biomedcentral.com)
  • Gingiva is an integral part of the periodontium and has recently been identified as a source of adult gingiva-derived mesenchymal stem cells (GMSCs). (nih.gov)
  • Flow cytometry demonstrated cells isolated from healthy and diseased gingiva met the criteria defining mesenchymal stem cells (MSCs). (nih.gov)
  • This study in mice with established collagen-induced arthritis (CIA) was undertaken to determine whether substitution of human gingiva-derived mesenchymal stem cells (G-MSCs) would significantly improve the therapeutic effects. (nih.gov)
  • The oral epithelium, also called the outer gingival epithelium, is a keratinized or para-keratinized covering of the oral surface of the attached gingiva and gingival papillae. (dvm360.com)
  • It is a stratified squamous keratinizing epithelium, that lines the vestibular and oral surfaces of the gingiva it extends from the mucogingival junction to the gingival epithelium except for the palatal epithelium where it blends with the palatal epithelium. (juniordentist.com)
  • This is the epithelium which covers the gingiva present in the sulcus depths. (juniordentist.com)
  • The gingiva is covered with Keratinized Stratified squamous epithelium the outer most layer of gingiva. (juniordentist.com)
  • The outer layers of the epithelium are keratinized and are stratified so the size of the cells increases as we go into the gingiva. (juniordentist.com)
  • it begins at the gingival margin and ends at the base of the sulcus where the junctional epithelium and attached gingiva begins. (wikipedia.org)
  • In the epithelium of the mouth, the attached gingiva exhibit rete pegs, while the sulcular and junctional epithelia do not. (wikipedia.org)
  • The attached gingiva meets with the loose alveolar mucosa at the mucogingival junction, also referred as the mucogingival line. (dvm360.com)
  • The mucogingival junction remains stationary throughout life, although the gingiva around it may change in height because of attachment loss. (dvm360.com)
  • Gingiva is the soft tissue around the teeth which is continous with the Mucosa of the Oral cavity, this junction is called the mucogingival junction. (juniordentist.com)
  • [5] [6] The attached gingiva lies between the free gingival line or groove and the mucogingival junction. (wikipedia.org)
  • Because the mucogingival junction remains stationary throughout adult life, changes in the width of attached gingiva are caused by the modification in the position of the coronal end. (dentaldevotee.com)
  • Epinephrine could evoke intense vasoconstriction propagating to the mucogingival junction, indicating the presence of spreading vasoconstriction in the human gingiva. (biomedcentral.com)
  • A 73-year-old White Spanish man presented a persistent nodular mass involving his upper gingiva. (springermedizin.de)
  • The marginal gingiva extends from the free gingival margin to the attached gingiva (Figure 2). (dvm360.com)
  • The gingival sulcus is a shallow space between the marginal gingiva and the tooth. (dvm360.com)
  • In clinical examination clear vesicular asymptomatic lesions were found on the attached and marginal gingiva in canine area. (biomedcentral.com)
  • The construction of Artificial gingiva begins by making an impression of labial surface of the bridge and ridge of the patient. (denturesaffordable.com)
  • Wax up of artificial gingiva. (denturesaffordable.com)
  • After excellent esthetics is attained, the wax artificial gingiva will be prepared for processing. (denturesaffordable.com)
  • Artificial gingiva is usually processed from 8 to 10 hours. (denturesaffordable.com)
  • Processed artificial gingiva. (denturesaffordable.com)
  • Artificial gingiva after trimming and polishing. (denturesaffordable.com)
  • Objectives: The aim of this study is to evaluate the effects of three different retraction agents on the color of dentin and artificial gingiva following the gingival retraction. (journalijdr.com)
  • Following the removal of the waxes, 3 mm artificial gingiva was created by a silicone material. (journalijdr.com)
  • After the calculation of ΔE values, the discoloration of the dentine and artificial gingiva was determined. (journalijdr.com)
  • We present the second case of oral amyloidosis arising in the gingiva ever reported, to the best of our knowledge. (springermedizin.de)
  • Localized amyloidosis of the gingiva is an extremely rare condition that seems to show no clinically distinct feature. (springermedizin.de)
  • Gingiva, commonly called the gum, is the soft tissue that covers and protects the root of the tooth. (innerbody.com)
  • Endoscopic visualization of the submarginal gingiva dental sulcus and tooth root surfaces. (nih.gov)
  • The invention relates to a tooth- and gingiva-cleaning construction which develops a vibration motion by the help of the in situ originating carbon dioxide gas in a perforated, from outside roughened membrane which is directly connected with the set of teeth and forms a cleaning tool. (google.com)
  • In the present study, the expression and localization of three basement membrane-specific molecules-laminin 5 (γ2 chain), type IV collagen (α1 chain), and laminin 10 (α5 chain)-and one tooth-specific molecule, amelotin, was analyzed in adult murine gingiva by using in situ hybridization and immunohistochemistry. (springer.com)
  • Clinical examination of her lower anterior teeth revealed tooth surface loss (attrition) and gingival abnormalities, such as recession, ulcerations without destruction of interdental papillae, mild swelling with loss of gingival striping with white diffuse lesions in both free and attached gingivae. (dental-update.co.uk)
  • The attached gingiva dissipates functional and masticatory stresses placed on the gingival tissues during common activities such as mastication, tooth brushing and speaking. (wikipedia.org)
  • The interdental gingiva takes up the space beneath a tooth contact point, between two adjacent teeth. (wikipedia.org)
  • The gingiva is attached to the tooth, which forms a seal between the mouth and the underlying bone. (icoi.org)
  • The width of attached gingiva increases with age and in supraerupted teeth, with the wear of the incisal edge and continued tooth eruption. (dentaldevotee.com)
  • Several predisposing conditions may contribute to gingival recession, including a thin alveolar housing, tooth malposition, insufficient supporting alveolar bone, and a deficient amount of attached gingiva, among others. (cdeworld.com)
  • The soft tissues and connective fibres that cover and protect the underlying cementum, periodontal ligament and alveolar bone are known as the gingivae. (wikipedia.org)
  • [4] Collagen fibres bind the attached gingiva tightly to the underlying periodontium including the cementum and alveolar bone and varies in length and width, [4] depending on the location in the oral cavity and on the individual. (wikipedia.org)
  • Mandibles of 4-month-old and 14- to 18-month-old freshly slaughtered steers were utilized to quantitate the immunoglobulin content of the dental pulp and gingiva. (nyu.edu)
  • Using a single radial immunodiffusion technique, IgG was found in lower concentrations in the pulp and gingiva than in sera. (nyu.edu)
  • The steer provided an animal model system for the study of immunoglobulin levels in normal dental pulp and gingiva. (nyu.edu)
  • Alshaarani F, Barngkgei I, Joury E, Elias K (2018) Itching Gingiva: An Early Sign of Pre-Inflammatory Pulp Necrosis or Unsuccessful Endodontic Treatment - A Case Series. (clinmedjournals.org)
  • Clinical examination revealed a solitary, well defined, soft tissue growth on the posterior gingiva measuring about 2.5 1.5 cm, extending from the lingual and distal aspect of 36 to posteriorly 1 cm short of the anterior border of the ramus. (hindawi.com)
  • We report a rare case of extra skeletal chondroma of the gingiva in a 31-year-old male patient following trauma to the anterior maxillary soft and hard tissues.Case Description: This is a case of a 31year old hypertensive patient with 3weeks history of gingival swelling in relation to the upper incisors which were fractured following an injury sustained from a motorbike fall. (who.int)
  • The gingiva shapers come in two different designs, concave anterior and concave posterior, to cope with the most varied indications. (sic-invent.com)
  • The high labial frenal attachment in mandibular anterior segment is most commonly associated with inadequate width of attached gingiva. (who.int)
  • The gingiva, or gum, is the keratinized oral mucosa covering the alveolar processes of the jaws, encircling the necks of erupted teeth (Figure 1). (dvm360.com)
  • Gingiva is the soft tissue covering that surrounds the teeth consisting of fibrous tissue which is continuous with the periodontial ligament and the mucosa covering the teeth. (juniordentist.com)
  • It is Differentiated by the line seen in the image which demarcates it due the dark color of the mucosa (due to high vasculature) and the light color of the gingiva (due to presence of more fibers) comparitively. (juniordentist.com)
  • The gingiva above the maxillary incisors and canines in a dog. (dvm360.com)
  • Authors report a rare case of a peripheral calcifying cystic odontogenic tumor of the maxillary gingiva. (biomedcentral.com)
  • The mean values of attached gingiva varied in different areas of the mouth with greatest width in maxillary central incisors and least in mandibular molars. (who.int)
  • It is caused by bacteria, which normally count as regular flora of the mouth, and it leads to redness and swelling of the gingiva up to ulcerations with bleeding. (priaid.ch)
  • Since plaque and tartar can bring a lot of bacteria to the gingiva, an infection may occur even though the bacteria are considered to be part of the normal oral flora. (priaid.ch)
  • Bacteria containing plaque accumulation in the gingival pockets are in direct proximity to the areas of disrupted gingiva, increasing the likelihood of bacteria escaping into the general circulation. (medscape.com)
  • This case report describes a rare benign tumor, which presented as a soft tissue swelling on posterior gingiva. (hindawi.com)
  • A 50-years-old man suffered from gingival itching in the left mandibular first molar (36) area, though the gingiva appeared healthy upon the clinical examination. (clinmedjournals.org)
  • This case report describes an unusual presentation of solitary neurofibroma on the lingual gingiva of the mandibular posterior region of a 22-year-old woman. (agd.org)
  • Capillary hemangioma of the gingiva in an adult: a. (who.int)
  • Weak and sporadic expression of type IV collagen in addition to laminin 10 in the gingiva indicates that these molecules undergo turnover less frequently in adult animals. (springer.com)
  • IMSEAR at SEARO: Width of attached gingiva in an Indian population: A descriptive study. (who.int)
  • Objectives: Attached gingiva is important for maintaining periodontium in a healthy state. (who.int)
  • A 32-year-old man was presented with bilateral hyperplasia of gingiva in upper canine regions. (biomedcentral.com)
  • Akut pada gingiva (itd ppl. (scribd.com)
  • Fremitus dan kebiasaan para fungsi Rangsangan antigen (plak ) yang berada pada sulkus gingiva masuk kedalam jaringan gingiva, menyebabkan respon sel mast yang mengeluarkan histamin dan beberapa mediator kimia lainnya sehingga menginduksi terjadinya vasodilatasi pembuluh darah. (prezi.com)
  • Sel endotel pada dinding pembuluh darah menghasilkan sitokin eselektin yang menyebabkan PMN terhenti, aktivasi oleh jaringan gingiva dengan mengeluarkan sitokin. (prezi.com)
  • A clinical and fine needle aspiration cytology study of gingiva in acute leukemia background oral manifestations are frequently the initial signs of acute leukemia prompting the patient to consult the dentist first. (salonmazal.org)
  • A model of human gingiva to be used in pharmacological, basic and clinical research was performed in vitro. (meta.org)
  • Clinical relevance Inadequate width of keratinised gingiva contributed to the difficulty in oral hygiene maintenance and ultimately poor gingival health. (who.int)
  • In 10 subjects, a custom-made algometer was used to apply pressure at a constant rate to 12 sites on the attached gingivae apical to teeth 11 to 16 and 41 to 46. (biomedsearch.com)
  • Defined as exposure of the root surface at the gingival margin, gingival recession is an apical shift in the position of the gingiva secondary to loss of attachment that can negatively affect smile esthetics, increase susceptibility to root caries, and lead to dentin hypersensitivity. (cdeworld.com)
  • The palatal gingival swelling was excised under local anesthesia, while gingivoplasty was performed on the labial gingiva of the same teeth. (who.int)
  • Because each therapy is characterized by the type of grafting material used, the manner in which the grafting material is harvested, and the respective technique for placing the grafting material, understanding their differences will benefit dentists when determining the most appropriate treatment for patients who present with gingival recession and areas of deficient attached gingiva. (cdeworld.com)
  • Understanding the differences among the therapies will benefit dentists when determining the most appropriate treatment for patients who present with gingival recession and areas of deficient attached gingiva. (cdeworld.com)
  • 11,14 Instead, FGGs aim to increase the strength of the soft tissue for resistance against future recession by increasing not only the vertical dimension of the gingiva, but more importantly, its horizontal thickness. (cdeworld.com)
  • The aim of this study is to evaluate the effects of lovastatin on the cell viability and osteogenic differentiation of human gingiva-derived stem cells. (alliedacademies.org)
  • Pain-pressure threshold in human gingivae. (biomedsearch.com)
  • This suggests that the pain-pressure threshold may be measured consistently in attached human gingivae. (biomedsearch.com)
  • This trial was registered in ClinicalTrials.gov titled as Evidence of Spreading Vasoconstriction in Human Gingiva with the reference number of NCT04131283 on 16 October 2019. (biomedcentral.com)
  • This makes it possible to print parts of the model that need a certain flexibility, such as Gingiva Masks on implant models. (envisiontec.com)
  • The SICvantage gingiva shaper is used for forming the gingiva following implant exposure or, alternatively, with transgingival healing. (sic-invent.com)
  • Further studies are needed to create more reliable color gingiva shade guide with a large number of patients and different races and places. (eastjmed.org)
  • Herein we report a case of cartilaginous choristoma in a 54-year-old male who presented with a swelling on right lower gingiva. (hindawi.com)
  • This paper reports one such rare case of cartilaginous choristoma of the gingiva. (hindawi.com)
  • The case presented as an exophytic mass of gingiva , clinically resembling traumatic fibroma . (bvsalud.org)
  • The purpose of this study is to report a case of bilateral symmetrical lymphangioma of the gingiva. (biomedcentral.com)
  • In this case series, we described four cases who had a common complaint of itching gingiva. (clinmedjournals.org)
  • In this case series, we described four cases for three female and one male patients, which had a common complaint of itching gingiva. (clinmedjournals.org)