Rats, Inbred Strains
Rats, Inbred WKY
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Rats, Inbred SHR
Hypertension
Pressure
Blood Pressure Monitoring, Ambulatory
Antihypertensive Agents
Drugs used in the treatment of acute or chronic vascular HYPERTENSION regardless of pharmacological mechanism. Among the antihypertensive agents are DIURETICS; (especially DIURETICS, THIAZIDE); ADRENERGIC BETA-ANTAGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; CALCIUM CHANNEL BLOCKERS; GANGLIONIC BLOCKERS; and VASODILATOR AGENTS.
Animals, Congenic
Disease Models, Animal
Phenotype
Kidney
Hypertension, Renal
Renin
Rats, Inbred Dahl
Hemodynamics
Rats, Sprague-Dawley
Blood Pressure Monitors
Body Weight
Vascular Resistance
Angiotensin II
An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.
Rats, Wistar
Sympathetic Nervous System
The thoracolumbar division of the autonomic nervous system. Sympathetic preganglionic fibers originate in neurons of the intermediolateral column of the spinal cord and project to the paravertebral and prevertebral ganglia, which in turn project to target organs. The sympathetic nervous system mediates the body's response to stressful situations, i.e., the fight or flight reactions. It often acts reciprocally to the parasympathetic system.
Desoxycorticosterone
Angiotensin-Converting Enzyme Inhibitors
A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.
Hypertrophy, Left Ventricular
Pulse
Analysis of Variance
Norepinephrine
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Hypotension
Arterial Pressure
Sodium, Dietary
Dose-Response Relationship, Drug
Captopril
A potent and specific inhibitor of PEPTIDYL-DIPEPTIDASE A. It blocks the conversion of ANGIOTENSIN I to ANGIOTENSIN II, a vasoconstrictor and important regulator of arterial blood pressure. Captopril acts to suppress the RENIN-ANGIOTENSIN SYSTEM and inhibits pressure responses to exogenous angiotensin.
Diet, Sodium-Restricted
Intracranial Pressure
Renin-Angiotensin System
A BLOOD PRESSURE regulating system of interacting components that include RENIN; ANGIOTENSINOGEN; ANGIOTENSIN CONVERTING ENZYME; ANGIOTENSIN I; ANGIOTENSIN II; and angiotensinase. Renin, an enzyme produced in the kidney, acts on angiotensinogen, an alpha-2 globulin produced by the liver, forming ANGIOTENSIN I. Angiotensin-converting enzyme, contained in the lung, acts on angiotensin I in the plasma converting it to ANGIOTENSIN II, an extremely powerful vasoconstrictor. Angiotensin II causes contraction of the arteriolar and renal VASCULAR SMOOTH MUSCLE, leading to retention of salt and water in the KIDNEY and increased arterial blood pressure. In addition, angiotensin II stimulates the release of ALDOSTERONE from the ADRENAL CORTEX, which in turn also increases salt and water retention in the kidney. Angiotensin-converting enzyme also breaks down BRADYKININ, a powerful vasodilator and component of the KALLIKREIN-KININ SYSTEM.
Telemetry
Baroreflex
A response by the BARORECEPTORS to increased BLOOD PRESSURE. Increased pressure stretches BLOOD VESSELS which activates the baroreceptors in the vessel walls. The net response of the CENTRAL NERVOUS SYSTEM is a reduction of central sympathetic outflow. This reduces blood pressure both by decreasing peripheral VASCULAR RESISTANCE and by lowering CARDIAC OUTPUT. Because the baroreceptors are tonically active, the baroreflex can compensate rapidly for both increases and decreases in blood pressure.
Chromosomes, Mammalian
Circadian Rhythm
Reference Values
Cardiovascular System
Aging
Risk Factors
Genotype
Hydrochlorothiazide
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
Amlodipine
Aldosterone
Sequence Analysis, DNA
Pressoreceptors
Cardiovascular Diseases
Prospective Studies
Vasodilation
Vasoconstriction
Rats, Transgenic
Sodium
Mesenteric Arteries
Age Factors
Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.
Venous Pressure
Losartan
Enalapril
Sphygmomanometers
Atenolol
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Myocardium
Angiotensin II Type 1 Receptor Blockers
Follow-Up Studies
Crosses, Genetic
Sex Factors
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Atmospheric Pressure
Double-Blind Method
Body Mass Index
An indicator of body density as determined by the relationship of BODY WEIGHT to BODY HEIGHT. BMI=weight (kg)/height squared (m2). BMI correlates with body fat (ADIPOSE TISSUE). Their relationship varies with age and gender. For adults, BMI falls into these categories: below 18.5 (underweight); 18.5-24.9 (normal); 25.0-29.9 (overweight); 30.0 and above (obese). (National Center for Health Statistics, Centers for Disease Control and Prevention)
Cardiac Output
Calcium Channel Blockers
Air Pressure
Cardiomegaly
Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Obesity
A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).
Cross-Sectional Studies
Nitric Oxide
A free radical gas produced endogenously by a variety of mammalian cells, synthesized from ARGININE by NITRIC OXIDE SYNTHASE. Nitric oxide is one of the ENDOTHELIUM-DEPENDENT RELAXING FACTORS released by the vascular endothelium and mediates VASODILATION. It also inhibits platelet aggregation, induces disaggregation of aggregated platelets, and inhibits platelet adhesion to the vascular endothelium. Nitric oxide activates cytosolic GUANYLATE CYCLASE and thus elevates intracellular levels of CYCLIC GMP.
Sex Characteristics
Chromosome Mapping
Aorta, Thoracic
African Continental Ancestry Group
Hypertension, Pregnancy-Induced
A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Phenylephrine
Pregnancy Complications, Cardiovascular
Hypertension, Malignant
Peptidyl-Dipeptidase A
A peptidyl-dipeptidase that catalyzes the release of a C-terminal dipeptide, -Xaa-*-Xbb-Xcc, when neither Xaa nor Xbb is Pro. It is a Cl(-)-dependent, zinc glycoprotein that is generally membrane-bound and active at neutral pH. It may also have endopeptidase activity on some substrates. (From Enzyme Nomenclature, 1992) EC 3.4.15.1.
Ventricular Pressure
The pressure within a CARDIAC VENTRICLE. Ventricular pressure waveforms can be measured in the beating heart by catheterization or estimated using imaging techniques (e.g., DOPPLER ECHOCARDIOGRAPHY). The information is useful in evaluating the function of the MYOCARDIUM; CARDIAC VALVES; and PERICARDIUM, particularly with simultaneous measurement of other (e.g., aortic or atrial) pressures.
Regression Analysis
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Dogs
Intracranial Hemorrhage, Hypertensive
Bleeding within the SKULL that is caused by systemic HYPERTENSION, usually in association with INTRACRANIAL ARTERIOSCLEROSIS. Hypertensive hemorrhages are most frequent in the BASAL GANGLIA; CEREBELLUM; PONS; and THALAMUS; but may also involve the CEREBRAL CORTEX, subcortical white matter, and other brain structures.
Blood Flow Velocity
Angiotensinogen
An alpha-globulin of about 453 amino acids, depending on the species. It is produced by the liver and secreted into blood circulation. Angiotensinogen is the inactive precursor of natural angiotensins. Upon successive enzyme cleavages, angiotensinogen yields angiotensin I, II, and III with amino acids numbered at 10, 8, and 7, respectively.
Echocardiography
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Carotid Arteries
Nitroprusside
RNA, Ribosomal, 16S
Adrenergic beta-Antagonists
Central Venous Pressure
Angiotensin Receptor Antagonists
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Treatment Outcome
Nifedipine
Receptor, Angiotensin, Type 1
Compliance
Atrial Natriuretic Factor
Nephrosclerosis
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Endothelium, Vascular
Prevalence
Perindopril
NG-Nitroarginine Methyl Ester
Cardiovascular Physiological Phenomena
Disease Susceptibility
Glomerular Filtration Rate
DNA, Ribosomal
Pregnancy
Hypertensive Encephalopathy
Brain dysfunction or damage resulting from sustained MALIGNANT HYPERTENSION. When BLOOD PRESSURE exceeds the limits of cerebral autoregulation, cerebral blood flow is impaired (BRAIN ISCHEMIA). Clinical manifestations include HEADACHE; NAUSEA; VOMITING; SEIZURES; altered mental status (in some cases progressing to COMA); PAPILLEDEMA; and RETINAL HEMORRHAGE.
Heart Ventricles
Autonomic Nervous System
The ENTERIC NERVOUS SYSTEM; PARASYMPATHETIC NERVOUS SYSTEM; and SYMPATHETIC NERVOUS SYSTEM taken together. Generally speaking, the autonomic nervous system regulates the internal environment during both peaceful activity and physical or emotional stress. Autonomic activity is controlled and integrated by the CENTRAL NERVOUS SYSTEM, especially the HYPOTHALAMUS and the SOLITARY NUCLEUS, which receive information relayed from VISCERAL AFFERENTS.
Bacterial Typing Techniques
Rats, Inbred BB
Potassium
An element in the alkali group of metals with an atomic symbol K, atomic number 19, and atomic weight 39.10. It is the chief cation in the intracellular fluid of muscle and other cells. Potassium ion is a strong electrolyte that plays a significant role in the regulation of fluid volume and maintenance of the WATER-ELECTROLYTE BALANCE.
Reflex
Escherichia coli
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Cerebrovascular Disorders
Brain
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Sodium Chloride Symporter Inhibitors
Cross-Over Studies
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Linear Models
Random Allocation
Methyldopa
Imidazoles
Nitric Oxide Synthase
Mutation
Lisinopril
Pulmonary Wedge Pressure
Arterioles
Prehypertension
Blood pressure levels that are between normotension and hypertension. Individuals with prehypertension are at a higher risk for developing cardiovascular diseases. Generally, prehypertension is defined as SYSTOLIC PRESSURE of 131-139 mm Hg and/or DIASTOLIC PRESSURE of 81-89 when the optimal is 120/80 mm Hg. For diabetics and other metabolism diseases the prehypertension is around 110-129/70-79 mm Hg.
Genetic Predisposition to Disease
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Animals, Outbred Strains
Virulence
Propranolol
Amino Acid Sequence
Gene Expression
Complement C6
A 105-kDa serum glycoprotein with significant homology to the other late complement components, C7-C9. It is a polypeptide chain cross-linked by 32 disulfide bonds. C6 is the next complement component to bind to the membrane-bound COMPLEMENT C5B in the assembly of MEMBRANE ATTACK COMPLEX. It is encoded by gene C6.
Angiotensin I
Kidney Cortex
Ventricular Function, Left
Hypotension, Orthostatic
A significant drop in BLOOD PRESSURE after assuming a standing position. Orthostatic hypotension is a finding, and defined as a 20-mm Hg decrease in systolic pressure or a 10-mm Hg decrease in diastolic pressure 3 minutes after the person has risen from supine to standing. Symptoms generally include DIZZINESS, blurred vision, and SYNCOPE.
Diabetes Mellitus, Type 2
A subclass of DIABETES MELLITUS that is not INSULIN-responsive or dependent (NIDDM). It is characterized initially by INSULIN RESISTANCE and HYPERINSULINEMIA; and eventually by GLUCOSE INTOLERANCE; HYPERGLYCEMIA; and overt diabetes. Type II diabetes mellitus is no longer considered a disease exclusively found in adults. Patients seldom develop KETOSIS but often exhibit OBESITY.
NIH Guide: SUPPLEMENTS FOR EMBRYONIC CRYOPRESERVATION OF HYPERTENSIVE RATSTRAINS
... appropriately inbred rats of fixed genotype are crucial. A system for banking specific hypertensive rat strains and appropriate ... range of pressures for each rat is suggested. The age and weight of the rats at the time of blood pressure determination, ... For example, WKY rats exhibit considerable heterogeneity when obtained from different sources. This heterogeneity is observed ... were convened to evaluate the current status and need for genetically defined animal models for the study of hypertension. The ...
MeSH Browser
Dahl Salt-Sensitive Rat Dahl Salt-Sensitive Rats Previous Indexing. Rats (1980-1981). Rats, Inbred Strains (1982-1998). Public ... Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure ... Rats, Inbred WF [B01.050.150.900.649.313.992.635.505.700.400.360] * Rats, Inbred WKY [B01.050.150.900.649.313.992.635.505.700. ... Dahl Hypertensive Rats Dahl Rat Dahl Rats Dahl Salt-Resistant Rats ...
MeSH Browser
Dahl Salt-Sensitive Rat Dahl Salt-Sensitive Rats Previous Indexing. Rats (1980-1981). Rats, Inbred Strains (1982-1998). Public ... Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure ... Rats, Inbred WF [B01.050.150.900.649.313.992.635.505.700.400.360] * Rats, Inbred WKY [B01.050.150.900.649.313.992.635.505.700. ... Dahl Hypertensive Rats Dahl Rat Dahl Rats Dahl Salt-Resistant Rats ...
Hypertension in Metabolic Syndrome: Vascular Pathophysiology
In particular, the Zucker fatty rat and the spontaneously hypertensive obese rat (SHROB). This one suffers macro- and ... Rat. The obese spontaneously hypertensive rat (SHROB), also known as Koletsky rat, is a rat strain of spontaneous hypertension ... Interestingly, control lean SHROB rats also develop diabetic retinopathy [142]. The effect of diet on blood pressure changes ... V. Sexl, G. Mancusi, G. Raberger, and W. Schutz, "Age-related changes in vascular reactivity in genetically diabetic rats," ...
Buy Ritosin Online
To study the clinical significance of presenting blood pressure parameters and heart rate in patients with hypertensive crisis ... WKY) rats, we determined the surface and volume densities of cerebral capillaries, and the regional cerebral blood flow distal ... Understanding the effects of inbreeding and genetic drift within populations and hybridization between genetically ... regardless of the heterozygosity of strain-specific DNA sequences present in these mouse strains. Further research is needed to ...
PMID- 9085387
... sustained reduction of blood pressure in genetically hypertensive rats and provide important information for a potential gene ... Rats MH - Rats, Inbred SHR MH - Rats, Inbred WKY MH - Rats, Wistar MH - Receptors, Endothelin/*antagonists & inhibitors MH - ... PG - 144-7 AB - Strains of A. eucrenophila isolated from fresh water (2 strains) and infected fish (4 strains) were tested for ... antiglucocorticoid properties in the rat. PG - 749-53 AB - In the rat, the conformationally highly bent steroid 21-hydroxy-6, ...
UI - 97479605
... of blood pressure in genetically hypertensive rats and provide important information for a potential gene therapy approach to ... Rats MH - Rats, Inbred SHR MH - Rats, Inbred WKY MH - Rats, Wistar MH - Receptors, Endothelin/*ANTAGONISTS & INHIBITORS MH - ... Strains of A. eucrenophila isolated from fresh water (2 strains) and infected fish (4 strains) were tested for haemolytic ... Rat livers were cold- preserved in University of Wisconsin solution for 30 hours then subjected to 1-hour warm ischemia after ...
Myocardium. Medical search
Inbred C57BLFerretsAnimals, NewbornRats, NudeMice, KnockoutRats, Inbred LewRats, Inbred WKYRats, Inbred Strains ... Blood Pressure. PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.. ... Abstract To elucidate the mechanisms controlling pH i in myocardium of the spontaneously hypertensive rat (SHR), experiments ... Genetically developed small pigs for use in biomedical research. There are several strains - Yucatan miniature, Sinclair ...
Descriptors in 2008 MeSH. Preferred term only. November 7, 2007
Inbred LEC Rats, Inbred Lew Rats, Inbred OLETF Rats, Inbred SHR Rats, Inbred Strains Rats, Inbred WF Rats, Inbred WKY Rats, ... Blood Physiology Blood Platelet Disorders Blood Platelets Blood Preservation Blood Pressure Blood Pressure Determination Blood ... Genetically Modified Animals, Inbred Strains Animals, Laboratory Animals, Newborn Animals, Outbred Strains Animals, Poisonous ... Nucleotide Exchange Factors ras Proteins ras-GRF1 Rat-Bite Fever Rate Setting and Review Ratibida Rationalization Rats Rats, ...
Spontaneously hypertensive2
- In particular, the Zucker fatty rat and the spontaneously hypertensive obese rat (SHROB). (hindawi.com)
- To demonstrate the potential therapeutic effects of somatic gene delivery in treating hypertension, we used spontaneously hypertensive rats (SHR) as a model. (nih.gov)
Hypertension9
- SUPPLEMENTS FOR EMBRYONIC CRYOPRESERVATION OF HYPERTENSIVE RATSTRAINS NIH GUIDE, Volume 21, Number 38, October 23, 1992 PA NUMBER: PA-93-010 P.T. 34 Keywords: Preservation of Organs/Tissue Hypertension Biological Resources National Heart Lung and Blood Institute PURPOSE The objective of this supplement program is to preserve embryos from phenotypically and genotypically unique rat strains used in hypertension research. (nih.gov)
- RESEARCH OBJECTIVES Summary The objective of this program is to preserve phenotypically and genotypically unique rat strains used in hypertension research. (nih.gov)
- The administrative supplement program will allow unique and valuable strains to be preserved so that both existing and newly developed models of hypertension, including those derived from traditional breeding techniques as well as molecular genetic technologies, will be available to investigators for future use. (nih.gov)
- Background The impetus for this program comes from deliberations by the NHLBI Arteriosclerosis, Hypertension, and Lipid Metabolism Advisory Committee (AHLMAC) and two separate expert panels of scientists that were convened to evaluate the current status and need for genetically defined animal models for the study of hypertension. (nih.gov)
- The expert panels noted the lack of standardized genetic rat models of hypertension due to independent breeding and the absence of appropriate inbred controls. (nih.gov)
- The panels assessed the extent to which phenotypic and genotypic variability among genetic rat models of hypertension is impeding research in the field. (nih.gov)
- Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. (nih.gov)
- PG - 229-36 AB - The tissue kallikrein-kinin system has been postulated to play a role in blood pressure homeostasis and the pathogenesis of clinical hypertension. (nih.gov)
- These results show that kallikrein gene delivery causes a sustained reduction of blood pressure in genetically hypertensive rats and provide important information for a potential gene therapy approach to human hypertension and related diseases. (nih.gov)
Arterial2
- There is a clear association between body mass index and arterial pressure even in nonobese, lean people [ 4 - 6 ]. (hindawi.com)
- The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation. (lookformedical.com)
High blood pr3
- Funds will be provided to investigators with active grants from the National Heart, Lung, and Blood Institute (NHLBI) so that embryos of hypertensive and normotensive control rat strains with well-defined phenotypic and genotypic characteristics that are of value to the study of high blood pressure can be cryopreserved for future revitalization and use. (nih.gov)
- In 1988, Reaven, hypothesized that insulin resistance is the common etiological factor of a group of disorders, such as high blood pressure, hyperinsulinemia, high levels of low density lipoproteins (LDL), triglycerides, and cholesterol, and low levels of high density lipoproteins (HDL). (hindawi.com)
- A single injection of naked human kallikrein DNA constructs caused a prolonged reduction of high blood pressure for up to 8 weeks. (nih.gov)
Vessels3
- Quoting prof. Yki-Järvinen "…after all, from a clinical point of view, type II diabetes mellitus is a disease of blood vessels, not muscle. (hindawi.com)
- The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. (lookformedical.com)
- The circulation of blood through the CORONARY VESSELS of the HEART. (lookformedical.com)
Tissue3
- A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. (lookformedical.com)
- Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION). (lookformedical.com)
- Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. (lookformedical.com)
Heart3
- This program announcement, Supplements for Embryonic Cryopreservation of Hypertensive Rat Strains, is related to the priority area of heart disease and stroke. (nih.gov)
- NECROSIS of the MYOCARDIUM caused by an obstruction of the blood supply to the heart (CORONARY CIRCULATION). (lookformedical.com)
- Damage to the MYOCARDIUM resulting from MYOCARDIAL REPERFUSION (restoration of blood flow to ischemic areas of the HEART. (lookformedical.com)
Result1
- This effort is necessary due to extensive genetic heterogeneity associated with many hypertensive rat strains and to the emergence of new molecular genetic technologies that will result in the availability of many new strains in the near future. (nih.gov)
Muscle1
- It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow. (lookformedical.com)