Polymorphism, Single Nucleotide
Genotype
Haplotypes
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Genetics, Population
Alleles
Genetic Predisposition to Disease
Gene Frequency
Linkage Disequilibrium
Phenotype
Selection, Genetic
Models, Genetic
Sequence Analysis, DNA
Geography
Microsatellite Repeats
Genetic Association Studies
Biological Evolution
Case-Control Studies
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Evolution, Molecular
Genetic Markers
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Genome, Human
Base Sequence
Genome-Wide Association Study
Genetic Loci
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Quantitative Trait, Heritable
Pharmacogenetics
DNA Copy Number Variations
Chromosome Mapping
Gene Flow
INDEL Mutation
A mutation named with the blend of insertion and deletion. It refers to a length difference between two ALLELES where it is unknowable if the difference was originally caused by a SEQUENCE INSERTION or by a SEQUENCE DELETION. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a FRAMESHIFT MUTATION.
DNA, Mitochondrial
Crosses, Genetic
European Continental Ancestry Group
Heterozygote
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Antigenic Variation
Change in the surface ANTIGEN of a microorganism. There are two different types. One is a phenomenon, especially associated with INFLUENZA VIRUSES, where they undergo spontaneous variation both as slow antigenic drift and sudden emergence of new strains (antigenic shift). The second type is when certain PARASITES, especially trypanosomes, PLASMODIUM, and BORRELIA, survive the immune response of the host by changing the surface coat (antigen switching). (From Herbert et al., The Dictionary of Immunology, 4th ed)
Mutation
Asian Continental Ancestry Group
Phylogeography
Environment
Breeding
Risk Factors
Epistasis, Genetic
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Random Amplified Polymorphic DNA Technique
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Population Dynamics
Inheritance Patterns
Polymorphism, Restriction Fragment Length
Genetic Linkage
Principal Component Analysis
Ecosystem
Cluster Analysis
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
Hybridization, Genetic
Seasons
Adaptation, Biological
Cohort Studies
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
Drosophila melanogaster
Recombination, Genetic
Adaptation, Physiological
Genome
Gene-Environment Interaction
Amplified Fragment Length Polymorphism Analysis
Analysis of Variance
Multifactorial Inheritance
Reproducibility of Results
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Ethnic Groups
Catechol O-Methyltransferase
Bayes Theorem
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
DNA Primers
Genomic Structural Variation
Genotyping Techniques
Algorithms
Exons
Endangered Species
Trees
Genetic Structures
Sequence Alignment
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Amino Acid Sequence
Mating Preference, Animal
Genetic Fitness
African Continental Ancestry Group
Models, Biological
Computational Biology
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Genetic Speciation
Computer Simulation
Animals, Inbred Strains
Genetic Pleiotropy
Demography
Gene Dosage
The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.
HapMap Project
Risk
Ecology
The branch of science concerned with the interrelationship of organisms and their ENVIRONMENT, especially as manifested by natural cycles and rhythms, community development and structure, interactions between different kinds of organisms, geographic distributions, and population alterations. (Webster's, 3d ed)
Pinus
Genetic Testing
Promoter Regions, Genetic
Climate
Introns
Models, Statistical
Chromosomes, Human, Y
Likelihood Functions
Regression Analysis
Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable.
Fertility
High-Throughput Nucleotide Sequencing
Techniques of nucleotide sequence analysis that increase the range, complexity, sensitivity, and accuracy of results by greatly increasing the scale of operations and thus the number of nucleotides, and the number of copies of each nucleotide sequenced. The sequencing may be done by analysis of the synthesis or ligation products, hybridization to preexisting sequences, etc.
Host-Parasite Interactions
Oligonucleotide Array Sequence Analysis
Sex Characteristics
Linear Models
Population Groups
Minisatellite Repeats
Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.
Serotonin Plasma Membrane Transport Proteins
Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of serotonergic neurons. They are different than SEROTONIN RECEPTORS, which signal cellular responses to SEROTONIN. They remove SEROTONIN from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS. Regulates signal amplitude and duration at serotonergic synapses and is the site of action of the SEROTONIN UPTAKE INHIBITORS.
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Cytochromes b
Circadian Rhythm
Conservation of Natural Resources
Gene Expression Profiling
Gene Expression Regulation
Observer Variation
The failure by the observer to measure or identify a phenomenon accurately, which results in an error. Sources for this may be due to the observer's missing an abnormality, or to faulty technique resulting in incorrect test measurement, or to misinterpretation of the data. Two varieties are inter-observer variation (the amount observers vary from one another when reporting on the same material) and intra-observer variation (the amount one observer varies between observations when reporting more than once on the same material).
Butterflies
Odds Ratio
The ratio of two odds. The exposure-odds ratio for case control data is the ratio of the odds in favor of exposure among cases to the odds in favor of exposure among noncases. The disease-odds ratio for a cohort or cross section is the ratio of the odds in favor of disease among the exposed to the odds in favor of disease among the unexposed. The prevalence-odds ratio refers to an odds ratio derived cross-sectionally from studies of prevalent cases.
Nutrigenomics
Software
Ecotype
Pedigree
Plant Leaves
Pan troglodytes
Smegmamorpha
Group of fish under the superorder Acanthopterygii, separate from the PERCIFORMES, which includes swamp eels, mullets, sticklebacks, seahorses, spiny eels, rainbowfishes, and KILLIFISHES. The name is derived from the six taxa which comprise the group. (From http://www.nanfa.org/articles/Elassoma/elassoma.htm, 8/4/2000)
Sex Factors
Maleness or femaleness as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or effect of a circumstance. It is used with human or animal concepts but should be differentiated from SEX CHARACTERISTICS, anatomical or physiological manifestations of sex, and from SEX DISTRIBUTION, the number of males and females in given circumstances.
Cistus
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Genetic Heterogeneity
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
African Americans
Seeds
Daphnia
Cattle
Quercus
Genetics, Medical
Asia
The largest of the continents. It was known to the Romans more specifically as what we know today as Asia Minor. The name comes from at least two possible sources: from the Assyrian asu (to rise) or from the Sanskrit usa (dawn), both with reference to its being the land of the rising sun, i.e., eastern as opposed to Europe, to the west. (From Webster's New Geographical Dictionary, 1988, p82 & Room, Brewer's Dictionary of Names, 1992, p34)
Temperature
Genetic Diseases, Inborn
Amino Acid Substitution
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent amino acid is substituted, the protein may retain wild-type activity. Substitution may also diminish, enhance, or eliminate protein function. Experimentally induced substitution is often used to study enzyme activities and binding site properties.
Arabidopsis
Mutation Rate
Continental Population Groups
Chromosomes
DNA, Ribosomal Spacer
Logistic Models
Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.
Reference Values
Animals, Wild
Beetles
Human Genome Project
Polyploidy
DNA Fingerprinting
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
Mutation, Missense
Gene Pool
Exome
RNA, Messenger
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
5' Flanking Region
Enzymes
Chromosomes, Plant
Hidden genetic variability within electromorphs in finite populations. (1/30484)
The amount of hidden genetic variability within electromorphs in finite populations is studied by using the infinite site model and stepwise mutation model simultaneously. A formula is developed for the bivariate probability generating function for the number of codon differences and the number of electromorph state differences between two randomly chosen cistrons. Using this formula, the distribution as well as the mean and variance of the number of codon differences between two identical or nonidentical electromorphs are studied. The distribution of the number of codon differences between two randomly chosen identical electromorphs is similar to the geometric distribution but more leptokurtic. Studies are also made on the number of codon differences between two electromorphs chosen at random one from each of two populations which have been separated for an arbitrary number of generations. It is shown that the amount of hidden genetic variability is very large if the product of effective population size and mutation rate is large. (+info)The Lewontin and Krakauer test on quantitative characters. (2/30484)
It is shown that LEWONTIN and KRAKAUER's test could also be applied to quantitative characters that do not show important dominance and epistatic genetic variances. The design of experiments for this purpose and the error of the estimation of F are discussed. (+info)Expression of the naturally occurring truncated trkB neurotrophin receptor induces outgrowth of filopodia and processes in neuroblastoma cells. (3/30484)
We have investigated the effects of the truncated trkB receptor isoform T1 (trkB.T1) by transient transfection into mouse N2a neuroblastoma cells. We observed that expression of trkB.T1 leads to a striking change in cell morphology characterized by outgrowth of filopodia and processes. A similar morphological response was also observed in SH-SY5Y human neuroblastoma cells and NIH3T3 fibroblasts transfected with trkB.T1. N2a cells lack endogenous expression of trkB isoforms, but express barely detectable amounts of its ligands, brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4). The morphological change was ligand-independent, since addition of exogenous BDNF or NT-4 or blockade of endogenous trkB ligands did not influence this response. Filopodia and process outgrowth was significantly suppressed when full-length trkB.TK+ was cotransfected together with trkB.T1 and this inhibitory effect was blocked by tyrosine kinase inhibitor K252a. Transfection of trkB.T1 deletion mutants showed that the morphological response is dependent on the extracellular, but not the intracellular domain of the receptor. Our results suggest a novel ligand-independent role for truncated trkB in the regulation of cellular morphology. (+info)Over-representation of a germline RET sequence variant in patients with sporadic medullary thyroid carcinoma and somatic RET codon 918 mutation. (4/30484)
The aetiology of sporadic medullary thyroid carcinoma is unknown. About 50% harbour a somatic mutation at codon 918 of RET (M918T). To investigate whether other RET sequence variants may be associated with or predispose to the development of sporadic medullary thyroid carcinoma, we analysed genomic DNA from the germline and corresponding tumour from 50 patients to identify RET sequence variants. In one patient, tumour DNA showed a novel somatic 12 bp in-frame deletion in exon 15. More interestingly, we found that the rare polymorphism at codon 836 (c.2439C > T; S836S) occurred at a significantly higher frequency than that in control individuals without sporadic medullary thyroid carcinoma (Fisher's exact test, P = 0.03). Further, among the nine evaluable cases with germline c.2439C/T, eight also had the somatic M918T mutation in MTC DNA which was more frequent than in patients with the more common c.2439C/C (89% vs 40%, respectively; Fisher's exact test, P = 0.01). These findings suggest that the rare sequence variant at codon 836 may somehow play a role in the genesis of sporadic medullary thyroid carcinoma. (+info)The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. (5/30484)
The nuclear receptor (NR) superfamily is the most abundant class of transcriptional regulators encoded in the Caenorhabditis elegans genome, with >200 predicted genes revealed by the screens and analysis of genomic sequence reported here. This is the largest number of NR genes yet described from a single species, although our analysis of available genomic sequence from the related nematode Caenorhabditis briggsae indicates that it also has a large number. Existing data demonstrate expression for 25% of the C. elegans NR sequences. Sequence conservation and statistical arguments suggest that the majority represent functional genes. An analysis of these genes based on the DNA-binding domain motif revealed that several NR classes conserved in both vertebrates and insects are also represented among the nematode genes, consistent with the existence of ancient NR classes shared among most, and perhaps all, metazoans. Most of the nematode NR sequences, however, are distinct from those currently known in other phyla, and reveal a previously unobserved diversity within the NR superfamily. In C. elegans, extensive proliferation and diversification of NR sequences have occurred on chromosome V, accounting for > 50% of the predicted NR genes. (+info)Hemoglobin Providence. A human hemoglobin variant occurring in two forms in vivo. (6/30484)
Hemoglobin Providence Asn and Hemoglobin Providence Asp are two abnormal hemoglobins which apparently arise from a single genetic change that substitutes asparagine for lysine at position 82 (EF6) in the beta chain of human hemoglobin. The second form appears to be thr result of a partial in vivo deamidation of the asparagine situated at position beta 82. Cellulose acetate and citrate agar electrophoresis of hemolysates from patients with this abnormality shows three bands. Globin chain electrophoresis at acid and alkaline pH shows three beta chains. These three chains correspond to the normal beta A chain and two abnormal beta chains. Sequence analysis indicates that the two abnormal chains differ from beta A at only position beta 82. In the two abnormal chains, the residue which is normally lysine is substituted either by asparagine or by aspartic acid. These substitutions are notable because beta 82 lysine is one of the residues involved in 2,3-diphosphoglycerate binding. Additionally, beta 82 lysine is typically invariant in hemoglobin beta chain sequences. Sequence data on the two forms of Hemoglobin Providence are given in this paper. The functional properties of these two forms are described in the next paper. (+info)Isolation and characterization of two mouse L cell lines resistant to the toxic lectin ricin. (7/30484)
Two variant mouse L cell lines (termed CL 3 and CL 6) have been selected for resistant to ricin, a galactose-binding lectin with potent cytotoxic activity. The resistant lines exhibit a 50 to 70% decrease in ricin binding and a 300- to 500-fold increase in resistance to the toxic effects of ricin. Crude membrane preparations of CL 3 cells have increased sialic acid content (200% of control), while the galactose, mannose, and hexosamine content is within normal limits. Both the glycoproteins and glycolipids of CL 3 cells have increased sialic acid, with the GM3:lactosylceramide ratios for parent L and CL 3 cells being 0.29 and 1.5, respectively. In contrast, the membranes of CL 6 cells have a decrease in sialic acid, galactose, and hexosamine content with mannose being normal. Both cell lines have specific alterations in glycosyltransferase activities which can account for the observed membrane sugar changes. CL 3 cells have increased CMP-sialic acid:glycoprotein sialyltransferase and GM3 synthetase activities, while CL 6 cells have decrease UDP-GlcNAc:glycoproteinN-acetylglucosaminyltransferase and DPU-galactose:glycoprotein galactosyltransferase activities. The increased sialic acid content of CL 3 cells serves to mask ricin binding sites, since neuraminidase treatment of this cell line restores ricin binding to essentially normal levels. However, the fact that neuraminidase-treated CL 3 cells are still 45-fold resistant to ricin indicates that either a special class of productive ricin binding sites is not being exposed or that the cell line has a second mechanism for ricin resistance. (+info)Constitutional genetic variation at the human aromatase gene (Cyp19) and breast cancer risk. (8/30484)
The activity of the aromatase enzyme, which converts androgens into oestrogens and has a major role in regulating oestrogen levels in the breast, is thought to be a contributing factor in the development of breast cancer. We undertook this study to assess the role of constitutional genetic variation in the human aromatase gene (Cyp19) in the development of this disease. Our genotyping of 348 cases with breast cancer and 145 controls (all Caucasian women) for a published tetranucleotide repeat polymorphism at intron 4 of the Cyp19 gene revealed the presence of six common and two rare alleles. Contingency table analysis revealed a significant difference in allelic distribution between cases and controls (chi2 5df = 13.52, P = 0.019). The allele measuring 171 bp was over-represented in cases; of 14 individuals homozygous for this allele, 13 were cases. These individuals had a higher incidence of cancer in family members and an earlier age at diagnosis than other cases. In sequencing Cyp19's coding exons and regulatory regions, we discovered a perfect association between a silent polymorphism (G-->A at Val80) and the high-risk genotype. Our conclusion is that constitutional genetic variation at the Cyp19 locus is associated with the risk of developing breast cancer, with the 171-bp allele serving as the high-risk allele. (+info)
The nature of quantitative genetic variation in drosophila. II* average dominance of abdominal bristle polygenes<...
High genetic diversity at the regional scale and possible speciation in Sebacina epigaea and S. incrustans | BMC Evolutionary...
Ch 3 - Nature Nurture & Human Diversity - Nature Nurture Nature Human Diversity 100 Oct 6 08 True or False 1 Even complex...
Contribution of trans regulatory eQTL to cryptic genetic variation in C. elegans | BMC Genomics | Full Text
Ethnicity Predicts How Gene Variations Affect Response To Schizophrenia Medications | EmaxHealth
The impact of human genetic variation on HIV disease in the era of HAART | BC Centre for Excellence in HIV/AIDS
Haplotype Variation and Linkage Disequilibrium in 313 Human Genes | Science
Natural genetic variation caused by small insertions and deletions in the human genome
Sex-Biased Evolutionary Forces Shape Genomic Patterns of Human Diversity
Population Diversity of ORFan Genes in Escherichia coli : Genome Biology and Evolution - oi
Natural Genetic Variation in Transcriptome Reflects Network Structure by Sergey Nuzhdin, Jennifer A. Brisson et al.
Human genetic variation - Wikipedia
Genetic diversity among INERA maize inbred lines with single nucleotide polymorphism (SNP) markers and their relationship with...
Drift, selection, or migration? Processes affecting genetic differentiation and variation along a latitudinal gradient in an...
640Lecture0705 - TYPES OF GENETIC VARIATION protein variation how do we measure variability structural similarity how...
The effect of deleterious mutations on neutral molecular variation. | Genetics
PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data from...
A systematic survey of loss-of-function variants in human protein-coding genes<...
Geographic distribution of genetic variation in the rare orchid Isotri by Emily Devlin
Human genetic variation/Human genetic variation - Wanweipedia/wanweibaike
The Adaptive Hypothesis of Clinal Variation Revisited: Single-Locus Clines as a Result of Spatially Restricted Gene Flow |...
Estimating KIR Haplotype Frequencies on a Cohort of 10,000 Individuals: A Comprehensive Study on Population Variations, Typing...
Population size influences the type of nucleotide variations in humans | BMC Genetics | Full Text
dna testing song - Research Foundation
9780131838765 - Race and Human Diversity: A Biocultural | eCampus.com
Heritability and coefficient of genetic variation analyses of phenotypic traits provide strong basis for high-resolution QTL...
Genetic Variation Influences How Sweet Or Bitter Alcohol Tastes To You
KVAR1 - Overview: Known Variant Analysis-1 Variant, Varies
NKX3.1 and β-catenin expression variations might be re | Open-i
Moffitt Cancer Center Researchers Discover Link between Inherited Genetic Variations, Outcomes of Non-Small Cell Lung Cancer...
Identification of common genetic variation that modulates alternative splicing. - Oxford Big Data Institute
Genomic Medicine
Distribution and effects of nonsense polymorphisms in human genes<...
The Genetic Architecture of Maize Flowering Time | Science
ASPPH | UNC Study Finds Genetic Variation May Protect Against Certain Oral Cancers
Diversity | Free Full-Text | Potential Population Genetic Consequences of Habitat Fragmentation in Central European Forest...
Some genetic variations may affect our health by altering how DNA coils and interacts in its 3-D shape - https://debuglies.com
Genetic Variations May Hold Clues to RA Severity, Outcomes - MPR
Contribution of Trans Regulatory eQTL to Cryptic Genetic Variation in C. Elegans - PubMed
Examining functional variation in oncogene biology : the role of somatic mutations and germline variation on c-Myc and c-Myb /...
Vive la Différence | I, Science
CBA seminar: On the maintenance of adaptive genetic variation to cope with environmental change: considerations from population...
RACE - History - Ancestry and DNA
Disovery of genetic variations to better understand breast cancer | Génome Québec
nbsp;How would different models of genetic variation affect genomic selection? | WCGALP Archive
Information Processing: Human genetic variation, Fst and Lewontins fallacy in pictures
Genetic variation and neurological disease<...
RNA-seq analysis reveals considerable genetic diversity and provides genetic markers saturating all chromosomes in the diploid...
Aneuvis: Web-based exploration of numerical chromosomal variation in single cells
Genetic diversity and population structure analysis between Indian red jungle fowl and domestic chicken using microsatellite...
Ex situ conservation - Offline Wikipedia
Genetic variation and population structure of the garden escaper Lupinus polyphyllus in Finland - CONVERIS Research Information...
Genome-wide patterns of genetic variation in sweet and grain sorghum (Sorghum bicolor) | Genome Biology | Full Text
Genetic diversity of Setipinna taty (Engraulidae) populations from the China Sea based on mitochondrial DNA control region...
Genetic variation and structure of house sparrow populations: is there an island effect? - Jensen - 2013 - Molecular Ecology -...
Spiral: A global reference for human genetic variation
Dienekes Anthropology Blog: High genetic differentiation between populations often driven by classic selective sweeps
A probabilistic method for identifying rare variants underlying complex traits | BMC Genomics | Full Text
Neandertal origin of genetic variation at the cluster of OAS immunity genes<...
The Most Comprehensive Catalog of Human Genome Variations - SciTechDaily
Genetic variants associated with caffeine intake ... ( Two genes in which variation affects...)
Population Genetic Diversity in the Australian Seascape: A Bioregion Approach
POT1 loss-of-function variants predispose to familial melanoma<...
Mitochondrial diversity in European and Chinese pigs is consistent with population expansions that occurred prior to...
Patient understanding of how genotype variation affects benefits of tamoxifen therapy for breast cancer | RTI
Genetic Diversity, Population Structure Analysis Using Ultra-High Throughput Diversity array Technology (DArTseq) in Different...
MEETINGS | Human Genome Variation Society
Genetic Diversity Analysis of Maize Hybrids Through Morphological Traits and Simple Sequence Repeat Markers
Lipid and sterol gene sequence variation in autism and correlates with neurodevelopmental status: A pilot study<...
Genetic Diversity Analysis by SSR of Summer Sowing Soybean in Hubei--《Journal of Wuhan Botanical Research》2007年06期
Cytoplasmic genetic variation and extensive cytonuclear interactions influence natural variation in the metabolome - Danish...
Agronomy | Free Full-Text | Genetic Variation in Soybean at the Maturity Locus E4 Is Involved in Adaptation to Long Days at...
Genetic Variation and Evolution of Floral Display in Primula farinosa
New data resource to aid the study of genetic variation and recombination in P. falciparum | Centre for Genomics and Global...
A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control. |...
Theories of Population Variation in Genes and Genomes: Christiansen, Freddy Bugge: Hardcover: 9780691133676: Powells Books
The molecular systematics of Leiopotherapon unicolor (Günther, 1859): testing for cryptic speciation in Australias most...
DiVA - Søkeresultat
Genetic Diversity and the Structure of Genealogies in Rapidly Adapting Populations
multiplephenotypes - ZarLab
Population genetic estimation of the loss of genetic diversity during horizontal transmission of HIV-1 | BMC Evolutionary...
Genetic diversity and population structure analysis based on the high density SNP markers in Ethiopian durum wheat (Triticum...
Are males just simpler?
Landmark deCODE Study Links Recombination Rate with Fertility: A Mechanism for Increasing Human Diversity | deCODE genetics
Calculating Variant Allele Fraction of Structural Variation in Next Generation Sequencing by Maximum Likelihood
WHI - Genome Wide Association Studies (GWAS)
Genetic variation among pelt sheep population using microsatellite markers
| African Journal of Biotechnology
Selection in Natural Populations - Jeffry B. Mitton - Google Books
Essay on Genetic Diversity at Meiosis | Proessay.com
Plus it
The effects of stabilizing and directional selection on phenotypic and genotypic variation in a population of RNA enzymes -...
Genetic variation
Genetic diversity Genetic variability Human genetic variation "What is genetic variation?". EMBL-EBI Train online. 2017-06-05. ... "Genetic Variation" in Griffiths, A.J.F. Modern Genetic Analysis, Vol 2., p. 7 "How is Genetic Variation Maintained in ... Genetic variation can be divided into different forms according to the size and type of genomic variation underpinning genetic ... Genetic variation can be identified at many levels. Identifying genetic variation is possible from observations of phenotypic ...
Genetic variation (disambiguation)
Genetic variation may refer to Genetic diversity Genetic variability Genetic variance Genetic variation Genetic variant ( ... This disambiguation page lists articles associated with the title Genetic variation. If an internal link led you here, you may ...
Human genetic variation
... is the genetic differences in and among populations. There may be multiple variants of any given gene ... When copy number variation is included, human-to-human genetic variation is estimated to be at least 0.5% (99.5% similarity). ... Structural variation is the variation in structure of an organism's chromosome. Structural variations, such as copy-number ... in Europe Genetic history of Europe Genetic history of indigenous peoples of the Americas Genetic history of South Asia Genetic ...
Copy number variation
"Huge genetic variation in healthy people". New Scientist. 7 August 2004. Carter NP (September 2004). "As normal as normal can ... Copy number variations were generally associated only with small tandem repeats or specific genetic disorders, therefore, copy ... Copy number variations appear to be higher in brain cells than in other cell types. A likely source of copy number variation is ... It was thought that these large-scale chromosomal rearrangements give rise to normal variation and genetic diseases, including ...
2000s
Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID 18096770. Vogel, Gretchen ( ... Human genetic variation Reprogramming cells High-energy cosmic rays Receptor visions Beyond silicon: oxide interfaces Quantum ... Genomes Project an international research effort to establish by far the most detailed catalogue of human genetic variation. ...
Stabilizing selection
This narrowing of phenotypes causes a reduction in genetic diversity in a population. Maintaining genetic variation is ... "Low genetic variation". evolution.berkeley.edu. Retrieved 2018-05-13. Linnen CR, Hoekstra HE (2009). "Measuring natural ... "Reconciling strong stabilizing selection with the maintenance of genetic variation in a natural population of black field ... "Variation in Clutch Sizes". web.stanford.edu. Retrieved 2018-05-13. "A Simple Definition and Prominent Examples of Stabilizing ...
Ancestry-informative marker
Pennisi, Elizabeth (2007). "Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID ... A set of aAIMs can be used to identify the ancestry of ancient populations and eventually quantify the genetic similarity to ... NGS enables the study of genetic markers by isolating specific gene sequences. One such method for sequence extraction is the ... Though AIM panels can be useful for disease screening, the Genetic Information Nondiscrimination Act (GINA) prevents the use of ...
Breakthrough of the Year
Human Genetic Variation". Science. 318 (5858): 1842-1843. doi:10.1126/science.318.5858.1842. PMID 18096770. Gretchen Vogel ( ... Human genetic variation 2008: Cellular reprogramming 2009: Ardipithecus ramidus 2010: The first quantum machine 2011: HIV ...
Genetic diversity
... area Evolutionary biology portal Biodiversity Center of diversity Genetic variation Genetic resources Human genetic variation ... Random mutations consistently generate genetic variation. A mutation will increase genetic diversity in the short term, as a ... Genetic diversity is the total number of genetic characteristics in the genetic makeup of a species, it ranges widely from the ... It is distinguished from genetic variability, which describes the tendency of genetic characteristics to vary. Genetic ...
History of the Basques
"European Genetic Variation". Online maps. Archived from the original on 5 December 2006. Collins, Roger (1990). The Basques ( ... Along the same lines, a genetic study carried out in 2001 revealed that the Y-chromosome of Celtic populations do not differ ... Juan Lizariturry from Uppsala University in Sweden analysed genetic material from eight Stone Age human skeletons found in El ... Throughout this region, which underwent similar cultural developments with some local variation, Aurignacian culture was ...
Mutation
Nonlethal mutations accumulate within the gene pool and increase the amount of genetic variation. The abundance of some genetic ... In the neutral theory of molecular evolution, neutral mutations provide genetic drift as the basis for most variation at the ... Mutation is the ultimate source of all genetic variation, providing the raw material on which evolutionary forces such as ... A 2007 study on genetic variations between different species of Drosophila suggested that, if a mutation changes a protein ...
Peter Keightley
His research investigates genetic variation and adaptation through the analysis of nucleotide variation within natural ... Keightley was educated at the University of Edinburgh where he was awarded a PhD in 1989 for research on genetic variation ... Barton, N. H.; Keightley, P. D. (2002). "Understanding quantitative genetic variation". Nature Reviews Genetics. 3 (1): 11-21. ... subscription required) Keightley, Peter (1988). Studies of quantitative genetic variation (PhD thesis). University of Edinburgh ...
FINDbase
Genetic variation Georgitsi, Marianthi; Viennas Emmanouil; Antoniou Dimitris I; Gkantouna Vassiliki; van Baal Sjozef; Petricoin ... FINDbase was founded in 2006 to be a relational database for these frequencies of causative genetic variations of inherited ... The Frequency of INherited Disorders database (FINDbase) is a database of frequencies of causative genetic variations worldwide ... a worldwide database for genetic variation allele frequencies updated". Nucleic Acids Res. 39 (Database issue): D926-32. doi: ...
Multiregional origin of modern humans
"Selection, nuclear genetic variation, and mtDNA". john hawks weblog. 5 September 2005. Retrieved 2011-01-05. Thorne, A.G.; ... Thorne, A.G.; Wolpoff, M. H.; Eckhardt, R.B. (1993). "Genetic variation in Africa". Science. 261 (5128): 1507-1508. Bibcode: ... "Variation in NAT1 and NAT2". john hawks weblog. 15 January 2006. Retrieved 2011-01-04. Garrigan, D.; Mobasher, Z.; Severson, T ... 2010-12-23). "Genetic history of an archaic hominin group from Denisova Cave in Siberia". Nature. 468 (7327): 1053-60. Bibcode: ...
Hugh Loxdale
... intra-clonal genetic variation; rapid evolution in insect populations due to various genetic-ecological mechanisms; population ... underwent increased genetic variation, so did that of its parasitoid. This suggested a fine-grained co-evolutionary tracking to ... 2010) Rapid genetic changes in natural insect populations. Ecological Entomology (special issue) 35, 155-164. Biron DG, Loxdale ... Loxdale has written reviews on absence of strict genetic uniformity in populations of clonal organisms such as aphids. This ...
Inbreeding
With continuous inbreeding, genetic variation is lost and homozygosity is increased, enabling the expression of recessive ... Inbreeding is especially problematic in small populations where the genetic variation is already limited. By inbreeding, ... There are genetic assays being scheduled for lions to determine their genetic diversity. The preliminary studies show results ... Ramel, C (1998). "Biodiversity and intraspecific genetic variation". Pure and Applied Chemistry. 70 (11): 2079-2084. CiteSeerX ...
Roland L. Fischer
ISBN 0-306-48484-6. Prescott, J.; Tepper, Beverly J. (2004). Genetic Variation in Taste Sensitivity. CRC Press. ISBN 0203023439 ... Genetic and Environmental Variation in Taste: Associations With Sweet Intensity, Preference, and Intake. Topics in Clinical ...
Sri Lankan Moors
Retrieved 2006-04-30.{{cite web}}: CS1 maint: unfit URL (link) Mastana, Sarabjit (November 1996). "Genetic variation in Sri ... The Nei genetic distance for Sinhalese and Moors is 0.0123, SL Tamil and Moors is 0.0233 while Indian Tamil and Moors 0.0293. ... According to the genetic distance calculated the Moors were closest to Sinhalese and then Sri Lankan Tamil with a significant ... 2021) in their genetic analysis of the Moors stated the following in their report: "In contrast, Sri Lankan Moors have ...
List of Sri Lankan Moors
Papiha, S.S.; Mastana, S.S.; Jaysekara, R. (October 1996). "Genetic Variation in Sri Lanka". Human Biology. 68 (5): 707-737 [ ...
Dwarf sperm whale
Chivers, S. J.; Leduc, R. G.; Robertson, K. M.; Barros, N. B.; Dizon, A. E. (2006). "Genetic Variation of Kogia spp. with ... The variation can either be due to loss of bones during preparation of a specimen, or individual variations. It is not known to ... Genetic testing in 2006 suggests that K. sima may actually represent two species, one in the Atlantic and one in the Indo- ... Dunphy-Daly, M. M.; Heithaus, M. R. (2007). "Temporal Variation in Dwarf Sperm Whale (Kogia sima) Habitat Use and Group Size ...
Color terminology for race
Jorde, Lynn B.; Wooding, Stephen P. (2004). "Genetic variation, classification and 'race'". Nature. 36 (11 Suppl): S28-S33. doi ... Ancestry, then, is a more subtle and complex description of an individual's genetic makeup than is race. This is in part a ... "Why Your Race Isn't Genetic". Pacific Standard. Retrieved 13 December 2014. [O]ngoing contacts, plus the fact that we were a ... with variation depending on author. René Lesson in 1847 presented a division into six groups based on simple color adjectives: ...
Drosophila silvestris
Craddock, EM; Johnson, WE (March 1979). "Genetic Variation in Hawaiian Drosophila. V. Chromosomal and Allozymic Diversity in ... There is some variation in the number of male tibial bristles, as 20-30 extra bristles can be found in the middle of the two ... Both of these fly species are native to Hawaii, and genetic similarities such as the sharing of a unique inversion in ... Genetic and phylogenetic relationships of natural populations of D. silvestris and D. heteroneura". Heredity. 56 (1): 87-96. ...
Genetic studies on Sinhalese
A study looking at genetic variation of the FUT2 gene in the Sinhalese and Sri Lankan Tamil population, found similar genetic ... Another study has also found "no significant genetic variation among the major ethnic groups in Sri Lanka". This is further ... July 2015). "Global analysis of genetic variations in a 56-bp variable number of tandem repeat polymorphisms within the human ... Mastana, Sarabjit (November 1996). "Genetic variation in Sri Lanka". Scientific Reports: 26-27. Soejima M, Koda Y (December ...
Consanguinity
Jorde, Lynn B; Wooding, Stephen P (2004). "Genetic variation, classification and 'race'". Nature Genetics. 36 (11s): S28-S33. ... Due to variation in geographical and ethnic background and the loci chosen to genotype there is some 2.4% variation expected. ... Coefficient of relationship Cognatic kinship Cousin marriage in the Middle East Endogamy Exogamy Genetic distance Genetic ... The extent to which the risk increases depends on the degree of genetic relationship between the parents; so the risk is ...
Albuca bracteata
Seed production provides genetic variation. Micropropagation of Albuca bracteata has been achieved. Bulblet production was ...
F-statistics
Early studies argued that 85-90% of the genetic variation is found within individuals residing in the same populations within ... Jorde, Lynn B; Wooding, Stephen P (2004). "Genetic variation, classification and 'race'". Nature Genetics. 36 (11s): S28-33. ... It is well established that the genetic diversity among human populations is low, although the distribution of the genetic ... This correlation is influenced by several evolutionary processes, such as genetic drift, founder effect, bottleneck, genetic ...
Basel Computational Biology Conference
2013 "Genetic Variation + Human Health" 2012 "ECCB'12, 11th European Conference on Computational Biology" in association with ... "Genetic Variation and Human Health". "European Conference on Computational Biology 2012". "Multiscale Modeling". "Regulation ...
Multiracial people
"Genetic variation, classification and 'race'". Nature Genetics. 36 (11 Suppl): S28-S33. doi:10.1038/ng1435. PMID 15508000. ... Genetic studies shows that Central Asian Turkic people and Hazara are a mixture of Northeast Asians and Indo-European people. ... According to genetic research, most Brazilians of all racial groups (except Asian-Brazilians and natives) are, to some extent, ... According to a recent genetic study in 2019, North African populations are composed of admixture of extensive gene flow from ...
Dandie Dinmont Terrier
Weiner, Michael P; Gabriel, Stacey B; Stephens, J Claiborne (2007). Genetic Variation: a Laboratory Manual. Cold Spring Harbor ... As a concerted effort has been made to breed out genetic abnormalities, there are no especially common conditions affecting the ...
Kīpuka
Craddock, Elysse M.; Johnson, Walter E. (1979). "Genetic Variation in Hawaiian Drosophila. V. Chromosomal and Allozymic ... any similarly noticeable variation or change of form, such as an opening in a forest, or a clear place in a congested setting, ...
Turquoise cichlid
... as there are significant variations in the appearance and genetic studies have shown clear differences between those from the ... Tuira River of Panama and the Atrato River of Colombia (genetic data is lacking for other populations). Adults have an ...
List of birds of the Falkland Islands
Variation in length of legs and bills enables multiple species to feed in the same habitat, particularly on the coast, without ... there are enough genetic differences to warrant their placement in a separate family. Leach's storm-petrel, Hydrobates ...
Assyria
Because of variation in artwork elsewhere, the artwork of early Assur was also highly variable depending on the time period, ... Assyrian continuity is generally scholarly accepted based on both historical and genetic evidence in the sense that the modern ...
Obstetric ultrasonography
Soft markers are variations from normal anatomy, which are more common in aneuploid fetuses compared to euploid ones. These ... the ISUOG recommends that pregnant patients who desire genetic testing have obstetric ultrasounds between 11 weeks' and 13 ...
Norovirus
Some people have common variations of the MDA-5 gene that could make them more susceptible to norovirus infection. Viruses in ... Vinjé J, Green J, Lewis DC, Gallimore CI, Brown DW, Koopmans MP (2000). "Genetic polymorphism across regions of the three open ... which can be further divided into different genetic clusters or genotypes. Noroviruses commonly isolated in cases of acute ...
Baum-Welch algorithm
Copy-number variations (CNVs) are an abundant form of genome structure variation in humans. A discrete-valued bivariate HMM ( ... and in particular genetic information. They have since become an important tool in the probabilistic modeling of genomic ... "Systematic prediction and validation of breakpoints associated with copy-number variations in the human genome". Proceedings of ...
Negrito
However, genetic studies suggest that they consist of several separate groups descended from the same ancient East Eurasian ... Our interpretations of negrito origins and adaptation must account for this phenotypic variation. Zhang, Xiaoming; Liu, Qi; ... February 2022). "Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia". Molecular Biology and ... Yang, Melinda A. (6 January 2022). "A genetic history of migration, diversification, and admixture in Asia". Human Population ...
Papillary carcinomas of the breast
... analyses studies have reported that EPS tumor cells in some individuals have copy number variations such as loses of genetic ... No specific genetic alterations have been as yet been clearly associated with the tumor cells in individuals diagnosed with IPC ... and gains of genetic material in the q arm of chromosome 1. Studies have also identified individuals with EPS tumors that have ... material in the q (i.e. long) arm of chromosome 16, gains of genetic material in the p (or short) arm of chromosome 16, ...
Drosophila simulans
Variation in Antiviral Protection Mediated By Different Wolbachia Strains in Drosophila simulans. PLOS. 11: e1000656-e1000656. ... Such progeny often have reduced fitness due to increased genetic homozygosity leading to expression of deleterious recessive ... Jallon, Jean-Marc; David, Jean R. (1987). "Variations in Cuticular Hydrocarbons Among the Eight Species of the Drosophila ...
Multiple system atrophy
September 2009). "Genetic variants of the alpha-synuclein gene SNCA are associated with multiple system atrophy". PLOS ONE. 4 ( ... revealed substantial variation in α-synuclein protein deposition across both cases and brain regions within cases, providing ... The study concluded that these repeats were absent in pathologically confirmed MSA, suggesting an alternative genetic cause. ... likely reflecting heterogeneity of the disease in different genetic backgrounds."[clarification needed] Another study ...
Metabolism
These genetic modifications usually aim to reduce the amount of energy used to produce the product, increase yields and reduce ... July 2005). "Diel variations in carbon metabolism by green nonsulfur-like bacteria in alkaline siliceous hot spring microbial ... Several variations on this basic structure exist, including backbones such as sphingosine in sphingomyelin, and hydrophilic ... Nucleic acids are critical for the storage and use of genetic information, and its interpretation through the processes of ...
Genomic imprinting
A hypothesis for the origin of this genetic variation states that the host-defense system responsible for silencing foreign DNA ... Natural selection for genomic imprinting requires genetic variation in a population. ... The first imprinted genetic disorders to be described in humans were the reciprocally inherited Prader-Willi syndrome and ... It is an epigenetic process that involves DNA methylation and histone methylation without altering the genetic sequence. These ...
Sex determination in Silene
For example, there are two genetic variations that can lead to male sterility in S. latifolia: if it possesses two Y ... leaving most of the genetic material in the Y chromosome intact. Several studies concentrated on Silene latifolia have shown a ... of possible sex-related genes that an individual Silene can have in one Y chromosome are what creates the rich variation of ...
Endless Forms Most Beautiful (book)
... coli to Elephants This chapter tells the tale of the genetic code, and the lac operon, showing that the environment and genetic ... Such variation is brought about by alterations in genes that control how cells in the developing embryo behave. Thus one cannot ... Evidently, a genetic switch could be reused for different purposes. 9. Paint It Black Carroll looks at zebra stripes, ... Most of the changes are in genetic control, not in proteins. 11. Endless Forms Most Beautiful Carroll concludes by revisiting ...
Genome size
As much as 90% of the genetic material can be lost when a species makes the evolutionary transition from a free-living to an ... For reasons of conceptual clarification, the various puzzles that remain with regard to genome size variation instead have been ... This process seems to be dominated by genetic drift resulting from small population size, low recombination rates, and high ... Wernegreen, J. J.; Moran, N. A. (1999-01-01). "Evidence for genetic drift in endosymbionts (Buchnera): analyses of protein- ...
Pirate perch
Fletcher, D. E.; Dakin, E. E.; Porter, B. A.; Avise, J. C. (2004). "Spawning behavior and genetic parentage in the pirate perch ... and variation in fish avoidance in colonizing beetles" (PDF). Ecology. 97 (12): 3517-3529. doi:10.1002/ecy.1593. PMID 27912024 ...
Dominique Bergmann
Bergmann, along with her team (collectively known as "The Bergmann Lab"), use a large variety of genetic, genomic and imaging ... methods to inquire into different variations of cell development, and they are also examining gene expression in singular cells ...
Transgenerational stress inheritance
Variations in maternal care, such as maternal licking and grooming, indicates reduced HPA axis reactivity in subsequent ... Small non-coding RNAs may serve as a potential mechanism for stress-related genetic changes in offspring. Mouse models of ... Epigenetic modification in response to stress results in molecular and genetic alterations that in turn results in mis- ...
Fragmentation (cell biology)
Here, DNA fragmentation is a molecular genetic technique that permits researchers to use recombinant DNA technology to prepare ... and manipulation of purified DNA fragment There are numerous experimental variations to this scheme, but these steps are ...
Marsh Arabs
2011). "In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of ... Other scholars have proposed historical and genetic links between the Marsh Arabs and the ancient Sumerians due shared ...
N6AMT1
"Interactive Influence of N6AMT1 and As3MT Genetic Variations on Arsenic Metabolism in the Population of Inner Mongolia, China ...
Interferon
"Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance". Nature. 461 (7262): 399-401. Bibcode: ... However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and ...
QIAGEN Silicon Valley
... collaborations with both Laboratory Corporation and Quest Diagnostics to develop a solution for scoring genetic variation for ...
Helmy Eltoukhy
Methods and systems for detecting genetic variants, (2015). Methods to detect rare mutations and copy number variation, (2016 ... Philippidis, Alex (14 Jan 2019). "Guardant Health Launches Blood-Based Early Cancer Assay for Research Use". Genetic ... EP 2893040, Talasaz, AmirAli & Eltoukhy, Helmy, "Methods to detect rare mutations and copy number variation", published 2016-11 ... EP 3087204, Eltoukhy, Helmy & Talasaz, AmirAli, "Methods and systems for detecting genetic variants", published 2015-07-15, ...
DNA annotation
2012). "An integrated map of genetic variation from 1,092 human genomes". Nature. 491 (7422): 56-65. Bibcode:2012Natur.491... ... Identifying the locations of genes and other genetic control elements is often described as defining the biological "parts list ... For DNA annotation, a previously unknown sequence representation of genetic material is enriched with information relating ...
Prunus × nudiflora
June 1998). "Genetic relationship of Prunus yedoensis, native and cultivar, based on internal transcribed spacer sequences of ... Most characters of king cherry were smaller in size than those of Yoshino cherry although the limits of variation of the ... nudiflora as it deserves to be a separate variety from Yoshino cherry according to the variations observed.[Note 1] Although ... nudiflora from Yoshino cherry when he proposed a new variation Prunus yedoensis var. nudiflora. According to Park Man-Kyu (1965 ...
Promoter (genetics)
Some cases of many genetic diseases are associated with variations in promoters or transcription factors. Examples include: ... Variations in promoters or transcription factors cause some diseases. Misunderstandings can result from using canonical ... Wikimedia Commons has media related to Genetic promoter regions. ORegAnno - Open Regulatory Annotation Database Identifying a ... Promoters are important gene regulatory elements used in tuning synthetically designed genetic circuits and metabolic networks ...
Sexual anomalies
These genetic abnormalities occur during the prenatal stage of an individuals' fetal development. During this stage, genetic ... DSDs caused by chromosomal variation generally do not present with genital ambiguity. This includes sex chromosome DSDs such as ... Genetic abnormalities or environmental factors that influence these procedures may lead to the incomplete development of the ... This helps classify the patient in one of the three main categories of DSD: chromosomal variation, gonadal development ...
Marine mammal
The variation observed in range size is a result of the different ecological requirements of each species and their ability to ... Baker, C. S.; Cipriano, F.; Palumbi, S. R. (1996). "Molecular genetic identification of whale and dolphin products from ... Mangel, J. C.; Whitty, T.; Medina-Vogel, G.; Alfaro-Shigueto, J.; Cáceres, C.; Godley, B. J. (2010). "Latitudinal variation in ... doi:10.1111/j.1748-7692.1999.tb00857.x. Hutchins, J. (1996). "Spatial and temporal variation in the density of northern cod and ...
CYP2B6
Elens L, Vandercam B, Yombi JC, Lison D, Wallemacq P, Haufroid V (September 2010). "Influence of host genetic factors on ... "Allelic variations in CYP2B6 and CYP2C19 and survival of patients receiving cyclophosphamide prior to myeloablative ... and CYP2B6 genetic polymorphisms on the induction of bupropion hydroxylation by rifampin". Drug Metabolism and Disposition. 39 ...
genetic variation | ScienceBlogs
The higher the FST the greater the proportion of genetic variation which can be attributed to between population differences, ... To provide a more extensive and complete sampling of human genetic variation, we have… ... but characterization of genetic variation and of relationships among populations across the continent has been enigmatic. We ... Dienekes points me to a new paper, Fine-scaled human genetic structure revealed by SNP microarrays: We report an analysis of ...
An integrated map of genetic variation from 1,092 human genomes | Nature
... the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. Here we describe ... By characterizing the geographic and functional spectrum of human genetic variation, ... Genetic variation within and between populations. The integrated data set provides a detailed view of variation across several ... Recent efforts to map human genetic variation by sequencing exomes1 and whole genomes2,3,4 have characterized the vast majority ...
Natural Protection of Genetic Variation
Genetic scent signals. Nature has created a special protection against dangerous reduction of genetic variation in the MHC gene ... It would be too harmful to the development of our basic organs to have too much genetic variation in the genetic systems ... will not preserve genetic variation in all gene systems. In some cases there is need for genetic stability. As living creatures ... Normally there is genetic variation in systems responsible for body size and form, colour, length and thickness of the fur and ...
Primary Open-Angle Glaucoma Linked to 2 Genetic Variations
Two genetic variations associated with primary open-angle glaucoma involve genes on chromosomes 9 and 8 that may interact with ... The investigators identified genetic variations associated with POAG, including NPG. These are the first genetic variations ... April 30, 2012 - Two genetic variations associated with primary open-angle glaucoma (POAG) involve genes on chromosomes 9 and ... Cite this: Primary Open-Angle Glaucoma Linked to 2 Genetic Variations - Medscape - Apr 30, 2012. ...
Frontotemporal Dementia and Frontotemporal Lobar Degeneration: Overview, Etiology, Genetic Distribution and Variation
Genetic Distribution and Variation. The cause of frontotemporal lobe dementia (FTD) is unknown, but, as discussed earlier, ... The genetic test for APOE-4 is less useful in FTD than in Alzheimer disease. A study by Mesulam et al found no association ... What is the genetic distribution of frontotemporal dementia (FTD)?. What is the prevalence of frontotemporal dementia (FTD) in ... Finally, a genetic disease with combined inclusion body myopathy and FTD has been described. [32] ...
Просмотр по теме "Genetic Variation"
Identification of Genetic Variation among Dengue Virus DEN-4 Isolates with Heteroduplex Analysis.
Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
Genetic variation in OGDH and human longevity
Genetic Variation and The Diverse Range of Behaviors in Autism | Disabled World
Research in human and animal models points to potential biological and genetic mechanisms contributing to the diversity of ... www.disabled-world.com/news/pressreleases/genetic-variation.php",Genetic Variation and The Diverse Range of Behaviors in Autism ... Genetic Variation and The Diverse Range of Behaviors in Autism. Published: 2022-11-10. Author: Society for Neuroscience , ... Genetic Variation and The Diverse Range of Behaviors in Autism , Society for Neuroscience (sfn.org). Disabled World makes no ...
Single-gene resolution of locally adaptive genetic variation in Mexican maize | bioRxiv
Single-gene resolution of locally adaptive genetic variation in Mexican maize. Daniel J Gates, Dan Runcie, Garrett M. Janzen, ... We further identify genetic associations with environment across Mexico and show that such loci are associated with variation ... Single-gene resolution of locally adaptive genetic variation in Mexican maize Message Subject (Your Name) has forwarded a page ... While considerable adaptive variation exists in traditional landraces, natural populations of crop wild relatives, and ex situ ...
Genetic Variation for Enzyme in Lung May Point to Cancer Susceptibility Gene, Mechanisms That May Cause Cancer
Patterns of phenotypic and genetic variation in three species of endemic Mesoamerican Peromyscus (Rodentia: Cricetidae)
... ... "Patterns of phenotypic and genetic variation in three species of endemic Mesoamerican Peromyscus (Rodentia: Cricetidae)," ... "Patterns of phenotypic and genetic variation in three species of endemic Mesoamerican Peromyscus (Rodentia: Cricetidae)," ... We investigated if previously proposed phenetic relationships among these 3 taxa were supported by morphometric and genetic ...
Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice | Journal of Neuroscience
Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice. Robert W. Williams, Richelle C. Strom, ... Genetic factors are most important in controlling this variation; 76% of the variance is heritable and up to 90% is ... How much of the remarkable variation in neuron number within a species is generated by genetic differences, and how much is ... Genetic and Environmental Control of Variation in Retinal Ganglion Cell Number in Mice ...
Genetic variations may modify cardiovascular benefit of aspirin | health.am
Genetic variations may modify cardiovascular benefit of aspirin ... Genetic variations may modify cardiovascular benefit of aspirin ... Now, a new study suggests that common genetic variation in the gene for catechol-O-methyltransferase (COMT) may modify the ... the investigators also wanted to learn if genetic variation in COMT would influence aspirins potential benefit. ... "This is one of the few cases where you can identify a single genetic polymorphism which has a significant interaction with ...
Genetic Variation in Picea mariana × P. rubens Hybrid Populations Assessed with ISSR and RAPD Markers
The objective of the present study was to assess the level of genetic variation in populations of P. mariana × P. rubens ... This confirms the genetic closeness of P. mariana and P. rubens species. ... The objective of the present study was to assess the level of genetic variation in populations of P. mariana × P. rubens ... Genetic Variation in Picea mariana × P. rubens Hybrid Populations Assessed with ISSR and RAPD Markers () ...
Genetic Variation of SARS Coronavirus in Beijing Hospital - Volume 10, Number 5-May 2004 - Emerging Infectious Diseases journal...
Genetic Variation of SARS Coronavirus in Beijing Hospital On This Page Materials and Methods Results Discussion Cite This ... The genetic variation of SARS-CoV remains limited in relation to many other RNA viruses such as HIV-1, HCV, and MHV. The ... Genetic Variation of SARS Coronavirus in Beijing Hospital. Emerging Infectious Diseases. 2004;10(5):789-794. doi:10.3201/ ... Xu, D., Zhang, Z., Chu, F., Li, Y., Jin, L., Zhang, L....Wang, F. (2004). Genetic Variation of SARS Coronavirus in Beijing ...
Study finds cancer-causing gene regulates genetic variation in prostate cancer
... discovered a novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation ... A group of researchers discovered a novel role for a cancer-causing gene in controlling an important genetic process that ... Study finds cancer-causing gene regulates genetic variation in prostate cancer. ANI , Updated: Oct 01, 2022 15:26 IST ... discovered a novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation ...
Genetic Variation in C57BL/6 ES Cells and Knockout Mice | Taconic Biosciences
Genetic variation between ES cell lines and their derivative animal models can distort experimental outcomes. How can you avoid ... Genetic Variation in C57BL/6 ES Cells and Kno.... Genetic Variation in C57BL/6 ES Cells and Knockout Mice. Philip Dubé, PhD. ... Control for genetic variation that may have been introduced into your knockout line and verify genetic background by SNP ... more recent studies have identified considerable genetic variation within C57BL/6 substrains (Figure 2)6. This known variation ...
Identification of Genetic Variation on the Horse Y Chromosome and the Tracing of Male Founder Lineages in Modern Breeds | PLOS...
Frontiers | Dissecting the Effect of Genetic Variation on the Hepatic Expression of Drug Disposition Genes across the...
The analysis revealed a substantial impact of genetic variation acting on drug biotransformation, allowed mapping of potential ... The analysis revealed a substantial impact of genetic variation acting on drug biotransformation, allowed mapping of potential ... mouse reference population is a promising model for pharmacogenomic studies because of its large amount of genetic variation, ... mouse reference population is a promising model for pharmacogenomic studies because of its large amount of genetic variation, ...
Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure
... Luo, Z., Adluru, N ... Genetic and Environmental Influences of Variation in Diffusion MRI Measures of White Matter Microstructure. ... Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure. Alexander, PhD, A ... Genetic and environmental influences of variation in diffusion MRI measures of white matter microstructure ...
"Genetic Variation and Differentiation of North American Waterfowl (Ana" by David W. Oates and Joann D. Principato
Genetic data strongly contradict inclusion of Chen canagica (emperor goose) within the genus Chen. Clangula hyemalis (oldsquaw ... Relationships were estimated using the resulting data from the patterns of allozyme variation and summarized in both phenetic ... with a starch-gel electrophoretic survey of protein variation at 25 loci. ... This study examines the genetic variation in 45 taxa of all tribes and most species of North American waterfowl (Anatidae) ...
New Genetic Variations Discovered in Swimming Behavior of Sperm Cells
... TOPICS:Cell BiologyGeneticsNew York University ... Be the first to comment on New Genetic Variations Discovered in Swimming Behavior of Sperm Cells. ... Some Sperms Poison Their Competitors: A Genetic Factor Helps Sperm Cells Outcompete Their Peers ... "Until now, the predominant view was that this variation in swimming behavior reflected the overall genetics of the male rather ...
Study finds a patchwork of genetic variation in the brain - Salk Institute for Biological Studies
Study finds a patchwork of genetic variation in the brain. Salk scientists find a surprising degree of variation among genomes ... Study finds a patchwork of genetic variation in the brain. Salk scientists find a surprising degree of variation among genomes ... Home - Salk News - Study finds a patchwork of genetic variation in the brain ... "Contrary to what we once thought, the genetic makeup of neurons in the brain arent identical, but are made up of a patchwork ...
Genetic Variation of Venezuelan Equine Encephalitis Virus Strains of the ID Variety in Colombia in: The American Journal of...
Genetic Variation of Venezuelan Equine Encephalitis Virus Strains of the ID Variety in Colombia published on Jan 1988 by The ... Genetic Variation of Venezuelan Equine Encephalitis Virus Strains of the ID Variety in Colombia ... To determine the degree of genetic variation within one serologic group of Venezuelan equine encephalitis virus and the ... Thus, genetic relatedness within Venezuelan equine encephalitis strains in Colombia seems to be a function of geography rather ...
Low genetic variation support bottlenecks in Scandinavian red deer | The James Hutton Institute
Cancer-causing gene regulates genetic variation in prostate cancer: Research
A novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate ... A novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate ... A novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate ... Cancer-causing gene regulates genetic variation in prostate cancer: Research. ANI , Updated: Sep 27, 2022 23:35 IST ...
Frost on Chickens | Genetic variations alter production and behavioral responses following heat stress in 2 strains of laying...
Genetic variations alter production and behavioral responses following heat stress in 2 strains of laying hens. ... Genetic variations alter production and behavioral responses following heat stress in 2 strains of laying hens.JPG (image/jpeg ... Genetic variations alter production and behavioral responses following heat stress in 2 strains of laying hens ... Genetic differences alter the type and degree of hensresponses and their ability to adapt to a stressor. This study examined ...
Phenotypic plasticity in Pinus pinaster δ13C: environment modulates genetic variation | Annals of Forest Science
Lack of genetic variation in tree ring δ13C suggests a uniform, stomatally-driven response to drought stress across Pinus ... Genetic variation for carbon isotope composition in honey mesquite (Prosopis glandulosa). Tree Physiol. 19: 583-589. [PubMed] [ ... Genetic variation in growth, carbon isotope discrimination, and foliar N concentration in Picea mariana: analyses from a half- ... Genetic-variation in carbon isotope discrimination and its relationship to growth under field conditions in full-sib families ...
GenesLociVariabilityPhenotypicGenomesVariantsDiversityDifferencesCorrelationsTraitsPolymorphismPopulationsStrainsMetabolismGeneticsIsolatesCommon genetic variationInfluencesCopy number variationsDifferentiationProportionAntigenicHumanTraitIdentificationGenomeStudySpeciesBehavioralTaxaGenomicDeterminantsSequenceDiseasesRare geneticSpecific geneticDifferent geneticAnalysesCOMTAdaptationMakeupVarianceImportant geneticInvestigatorsFactorsPinusPerson'sBehaviorsCardiovascularPatternsPopulationDisordersParametersResearchEvidenceAutismResearchersStudiesSuggestsSubstantial
Genes15
- April 30, 2012 - Two genetic variations associated with primary open-angle glaucoma (POAG) involve genes on chromosomes 9 and 14 that may interact with transforming growth factor-beta (TGF-beta), according to the results of a study reported online April 26 in PLoS Genetics . (medscape.com)
- A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
- Using GWAS, we further identify a large number of loci underlying the variation of responses to plant hormones, in particular to abscisic acid, find links between local adaptation and root responses to hormones, and finally using mutants for GWAS candidate genes, identify novel players involved in regulating hormone responses. (biorxiv.org)
- To characterize genetic variation of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) transmitted in the Beijing area during the epidemic outbreak of 2003, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients on our unit, the Beijing 302 Hospital. (cdc.gov)
- To characterize genetic variation among SARS-CoV transmitted in the Beijing area, we sequenced 29 full-length S genes of SARS-CoV from 20 hospitalized SARS patients, since S glycoprotein plays a key role in virus-host interaction and is predicted to be the main target of immune response ( 14 ). (cdc.gov)
- She said the enzyme may also lead to lung cancer by generating free radicals which are molecules that disrupt the copying of genes and cause genetic errors that can lead to cancer. (nih.gov)
- These findings indicate that different alleles at one or two genes have major effects on normal variation in ganglion cell number. (jneurosci.org)
- Alternative splicing is the process whereby segments of genes are shuffled to create different combinations of genetic code known as 'splice variants,' which provide the instructions to make proteins. (aninews.in)
- Some rare mutations in genes are known to be risk factors for the condition, and a range of commonly occurring changes in DNA sequence have been linked to autism but only account for a small proportion of its genetic basis. (technologynetworks.com)
- The aim of this study was to investigate whether previous identified and studied genetic polymorphisms at DRD2, ANKK1, DRD3, HTR2A, HTR2C, RGS2, COMT, and BDNF genes are associated with antipsychotic-related parkinsonism in elderly patients.This cross-sectional study included 150 inpatients aged 65 years and older who were treated with haloperidol. (eur.nl)
- To identify epilepsy risk signals, we tested all protein-coding genes for an excess of ultra-rare genetic variation among the cases, compared with control samples with no known epilepsy or epilepsy comorbidity sequenced through unrelated studies. (elsevier.com)
- For the individuals with familial non-acquired focal epilepsy, we found that five known epilepsy genes ranked as the top five genes enriched for ultra-rare deleterious variation. (elsevier.com)
- Interpretation We identified excess ultra-rare variation in known epilepsy genes, which establishes a clear connection between the genetics of common and rare, severe epilepsies, and shows that the variants responsible for epilepsy risk are exceptionally rare in the general population. (elsevier.com)
- I agree that my blood may be kept for future studies using my genes to help understand genetic links to medical conditions. (cdc.gov)
- Antimicrobial resistance occurs through different mechanisms, which include spontaneous (natural) genetic mutations and horizontal transfer of resistant genes through deoxyribonucleic acid (DNA). (who.int)
Loci2
- This study examines the genetic variation in 45 taxa of all tribes and most species of North American waterfowl (Anatidae) with a starch-gel electrophoretic survey of protein variation at 25 loci. (unl.edu)
- Here, we summarise and critique the last 10 years or so of molecular genetic ( DNA -based) research on intelligence , including the discovery of genetic loci associated with intelligence , DNA -based heritability, and intelligence 's genetic correlations with other traits. (bvsalud.org)
Variability7
- Natural genetic variability in the human population may lead to the spectrum of behaviors associated with autism diagnosis and contribute to differential rates of diagnosis and symptomology in males and females. (disabled-world.com)
- A knowledge of the drivers of genetic variability will help us understand the disease better, and improve treatments. (aninews.in)
- Although high levels of FOXA1 reduced splicing variability, the team found that FOXA1 enhanced the inclusion of genetic segments into splice variants that are strong markers of prostate cancer recurrence. (aninews.in)
- Dr Rajan said: "This study illustrates how we can exploit the power of genomics to make important scientific discoveries about how genetic variability in prostate cancer is controlled. (aninews.in)
- Genetic analysis of a soybean genetic pool using ISSR marker: Effect of gamma radiation on genetic variability. (scialert.net)
- Alternatively, small populations might exhibit larger variation in VA and QST if habitat fragmentation increases variability in habitat types. (datadryad.org)
- Human genome epidemiology is the basic science for translating genomic research, relating genetic variation with variability in health status among well-defined groups of people. (cdc.gov)
Phenotypic4
- Which type of selection leads to increased phenotypic and genetic variation quizlet? (scienceoxygen.com)
- Directional selection causes an increase in phenotypic (and genetic) variance associated with each module (Fig. (scienceoxygen.com)
- The Human Genome Variation Society (HGVS) has begun a grass-roots effort to compile a list of locus-specific databases (LSDBs), which are curated collections of mutations, often reported with associated phenotypic information ( 10 ). (cdc.gov)
- From this solid phenotypic foundation and importance for life , comes an interest in the environmental, social, and genetic aetiologies of intelligence , and in the foundations of intelligence differences in brain structure and functioning. (bvsalud.org)
Genomes4
- By characterizing the geographic and functional spectrum of human genetic variation, the 1000 Genomes Project aims to build a resource to help to understand the genetic contribution to disease. (nature.com)
- Recent efforts to map human genetic variation by sequencing exomes 1 and whole genomes 2 , 3 , 4 have characterized the vast majority of common single nucleotide polymorphisms (SNPs) and many structural variants across the genome. (nature.com)
- But if all cells get identical genomes there can be no genetic adaptation to changes in the environment. (pawpeds.com)
- This novel variation extends the pattern of variation catalogued in the 1000 Genomes and Exome Sequencing Projects to a spectrum of populations representing the wide range of West African genomic diversity. (elsevier.com)
Variants9
- Database of human genetic variants associated with longevity. (senescence.info)
- The findings were published in the journal Cell Reports, revealing how the gene influences the generation of genetic variants in prostate cancer that may predict disease relapse and represent new drug targets to improve patient survival. (aninews.in)
- By assessing alternative splicing in cell line models and primary cases of prostate cancer , the team found that high levels of FOXA1 limited genetic diversity towards splice variants that have a functional benefit for the cancer cells. (aninews.in)
- there are numerous genetic variants between these two strains which could subtly affect experimental outcomes. (taconic.com)
- Context: Biological and translational insights from large-scale, array-based genetic studies of fat distribution, a key determinant of metabolic health, have been limited by the difficulty in linking predominantly non-coding variants to specific gene targets. (cam.ac.uk)
- Sometimes these genetic variations, called copy number variants, are inherited from parents, while some appear for the first time in offspring. (technologynetworks.com)
- Scientists had wondered if some copy number variants that occur only rarely (in fewer than one in 100 people) might account for a significant proportion of autism's missing genetic component. (technologynetworks.com)
- By the 1990s, OMIM was adding more than 150 disease-related genetic variants per year, nearly all of them rare mutations discovered in families ( 1 ). (cdc.gov)
- There's also genetic variation within dengue virus types, with some variants showing higher levels of virulence. (cdc.gov)
Diversity5
- Research in human and animal models points to potential biological and genetic mechanisms contributing to the diversity of behaviors seen in autism. (disabled-world.com)
- While the CC lines are phenotypically diverse, their genetic diversity in drug disposition processes, such as detoxification reactions, is still largely uncharacterized. (frontiersin.org)
- These results are the first demonstration of genetic diversity in durum germplasm for FCR tolerance and they provide a basis for breeding for this trait. (edu.au)
- These individuals from CAAPA also comprise a large swath of the African Diaspora population and incorporate historical genetic diversity covering nearly the entire Atlantic coast of the Americas. (elsevier.com)
- In order to address this aspect, as well as to further understand relationships and geographic patterns, we carried out phylogenetic, genetic diversity, and population dynamic analyses using partial 18S rRNA and COI mtDNA sequences of Heligmosomoides specimens. (pdx.edu)
Differences9
- Analyses focused on behavioral and genomic differences between sibling pairs reveal genetic locations that could prove relevant to autism-related social difficulties. (disabled-world.com)
- Studies like those presented today confirm that autism is driven by sources of genetic variation that naturally exist in the human population," says Nicola Grissom, an assistant professor of psychology at the University of Minnesota who studies individual and sex differences in motivated behavior and executive function in mouse models. (disabled-world.com)
- How much of the remarkable variation in neuron number within a species is generated by genetic differences, and how much is generated by environmental factors? (jneurosci.org)
- This study is the first to demonstrate that genetic differences can directly affect the swimming behavior of sperm cells. (scitechdaily.com)
- It's been long established that sperm from different males vary in their characteristics because of the genetic differences between the males. (scitechdaily.com)
- Genetic differences alter the type and degree of hens'responses and their ability to adapt to a stressor. (usda.gov)
- Introduction Genetic factors contribute to individual differences in physical activity, but it remains uncertain whether the magnitude of the genetic effects is modified by variations in home environments. (jyu.fi)
- Thus, we tested for genetic differences between African and European workers in their preference for tasks associated with brood production by monitoring individual African and European workers cross-fostered in common colony environments. (elsevier.com)
- Genetic variation, brain, and intelligence differences. (bvsalud.org)
Correlations3
- These common genetic influences explained 93% of the trait correlations found in men and 85% in women. (jyu.fi)
- Anxiety showed significant positive genetic correlations with depression and insomnia as well as coronary artery disease, mirroring findings from epidemiological studies. (gale.com)
- The results on genetic correlations imply that selection on calf's birth weight leads on one hand to calves being born earlier and on the other hand to dams with later parturition. (uit.no)
Traits10
- Here we assess variation of root traits in response to perturbations of the auxin, cytokinin, and abscisic acid pathways in 192 Arabidopsis accessions. (biorxiv.org)
- Finally, we show that natural variation in root traits is significantly associated with climate parameters relevant for local adaption in Arabidopsis thaliana and that, in particular, ABA regulated lateral root traits are likely to be relevant for adaptation to soil moisture. (biorxiv.org)
- F. C. Yeh and T. J. B. Boyle, "Population Genetic Analysis of Codominant and Dominant Markers and Quantitative Traits," Belgian Journal of Botany, Vol. 129, 1997, pp. 157-163. (scirp.org)
- Individual trait measurements and pedigrees used in animal models to estimate quantitative genetic parameters for fifteen traits for nine brook trout populations from Cape Race, Newfoundland, Canada. (datadryad.org)
- Quantitative genetic parameter values (QGV) and QST values for fifteen traits for nine brook trout populations estimated from animal models and used to generate figures and in statistical analyses. (datadryad.org)
- The traits had coefficient of variation of 37 and 14%, respectively. (uit.no)
- The variation in both traits was affected by year and sex (male calves heavier) and by management factors, such as the age distribution of females and males. (uit.no)
- In both traits the heritability was moderate (0.23 and 0.24) with a high proportion of maternal genetic variation (0.23) in birth weight. (uit.no)
- The North Atlantic Oscillation (NAO) indices, summarizing the major weather conditions prior to rut, explained part of the annual variation in the traits. (uit.no)
- The amount of total genetic variation in relation to trait mean, or the evolvability, was 21% in birth date and 10% in birth weight indicating that selection could successfully be used to improve herd productivity and that the traits have substantial potential for adapting to possible changing environmental conditions. (uit.no)
Polymorphism1
- This is one of the few cases where you can identify a single genetic polymorphism which has a significant interaction with aspirin such that it affects whether or not it protects against cardiovascular disease," says first author Kathryn Hall, PhD, MPH, an investigator in the Division of General Medicine and Primary Care at BIDMC and Research Fellow at Harvard Medical School. (health.am)
Populations17
- One of the research team's major strengths was the great size of the patient populations that were under study, which empowered them to discover important genetic risk factors for glaucoma. (medscape.com)
- Because of the poor fidelity of RNA-dependent RNA polymerase, genetic variation typically forms a heterogeneous virus pool in RNA virus populations, including coronaviruses such as mouse hepatitis virus (MHV) ( 5 , 6 ). (cdc.gov)
- The objective of the present study was to assess the level of genetic variation in populations of P. mariana × P. rubens hybrids derived from artificial crosses. (scirp.org)
- R. Narendrula and K. Nkongolo, "Genetic Variation in Picea mariana × P. rubens Hybrid Populations Assessed with ISSR and RAPD Markers," American Journal of Plant Sciences , Vol. 3 No. 6, 2012, pp. 731-737. (scirp.org)
- K. K. Nkongolo, "RAPD Variations among Pure and Hybrid Populations of Picea mariana, P. rubens, and P. glauca (Pinaceae), and Cytogenetic Stability of Picea Hybrids: Identification of Species-Specific RAPD Markers," Plant Systematics and Evolution, Vol. 215, No. 1-4, 1999, pp. 229-239. (scirp.org)
- M. S. Mehes, K. K. Nkongolo and P. Michael, "Genetic Analysis of Pinus strobus and Pinus monticola Populations from Canada Using ISSR and RAPD Markers: Development of Genome-Specific SCAR Markers," Plant Systematics and Evolution, Vol. 267, No. 1-4, 2007, pp. 47-63. (scirp.org)
- Variations in growth, survival and carbon isotope composition (δ 13 C) among Pinus pinaster populations of different geographic origins. (afs-journal.org)
- Morphological and physiological variation in western redcedar ( Thuja plicata ) populations under contrasting soil water. (afs-journal.org)
- How population size influences quantitative genetic variation and differentiation among natural, fragmented populations remains unresolved. (datadryad.org)
- Small, isolated populations might occupy poor quality habitats and lose genetic variation more rapidly due to genetic drift than large populations. (datadryad.org)
- This suggests that (i) small populations of some species may retain adaptive potential according to commonly adopted quantitative genetic measures and (ii) populations of varying sizes experience a variety of environmental conditions in nature, however extremely large studies are likely required before any firm conclusions can be made. (datadryad.org)
- A table summarizing, per population, the number of females and males used to generate families as well as the range and mean number of crosses per male for the common garden experiment used to estimate quantitative genetic parameters for Cape Race brook trout populations. (datadryad.org)
- A primary goal of The Consortium on Asthma among African-ancestry Populations in the Americas (CAAPA) is to develop an 'African Diaspora Power Chip' (ADPC), a genotyping array consisting of tagging SNPs, useful in comprehensively identifying African specific genetic variation. (elsevier.com)
- This novel array covers African specific variation far better than other commercially available arrays, and will enable better GWAS analyses for researchers with individuals of African descent in their study populations. (elsevier.com)
- A recent study cataloging variation in continental African populations suggests this type of African-specific genotyping array is both necessary and valuable for facilitating large-scale GWAS in populations of African ancestry. (elsevier.com)
- This was supported by the high degree of divergence and differentiation found among populations, significant population structure between locations, and a modest positive association between geographic and genetic distances. (pdx.edu)
- Enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations. (cdc.gov)
Strains6
- Nongenetic factors are still appreciable and account for a coefficient of variation that averages ∼3.6% within inbred strains and isogenic F 1 hybrids. (jneurosci.org)
- Variation within isogenic strains appears to be generated mainly by developmental noise. (jneurosci.org)
- Our findings provide a resource for investigating drug disposition in the CC strains, and offer a new paradigm for integrating biotransformation reactions to corresponding variations in DNA sequences. (frontiersin.org)
- A reference enzootic strain from Colombia showed more genetic relatedness to three epizootic strains isolated in the same country, than to its own serogroup prototype strain isolated in Panama. (ajtmh.org)
- Thus, genetic relatedness within Venezuelan equine encephalitis strains in Colombia seems to be a function of geography rather than epidemiology. (ajtmh.org)
- Furthermore, over time, antigenic variation (antigenic drift) within a subtype may be so marked that infection or vaccination with one strain may not induce immunity to distantly related strains of the same subtype. (cdc.gov)
Metabolism5
- The analysis revealed a substantial impact of genetic variation acting on drug biotransformation, allowed mapping of potential joint genetic effects in the context of individual drugs, and demonstrated crosstalk between drug metabolism and lipid metabolism. (frontiersin.org)
- Because cytochrome P450 oxidoreductase helps regulate the activity of these enzymes, researchers suspect that normal variations in the POR gene may influence a person's response to particular drugs (drug metabolism). (medlineplus.gov)
- P450 oxidoreductase: genetic polymorphisms and implications for drug metabolism and toxicity. (medlineplus.gov)
- Impact of genetic variation in acrylamide metabolism on hemoglobin adduct levels. (cdc.gov)
- In this volume on carotenoids their chemical and physical characteristics, occurrence, production, use, analysis and human exposure, metabolism, kinetics and genetic variation are studied, as well as their cancer-preventive effects, other beneficial effects, carcinogenicity and other toxic effects. (who.int)
Genetics2
- Until now, the predominant view was that this variation in swimming behavior reflected the overall genetics of the male rather than the variable genetics of the individual sperm cells," explains Richard Borowsky, a professor emeritus in NYU's Department of Biology and the senior author of the paper, which will be published today (November 11) in the journal Scientific Reports . (scitechdaily.com)
- Genetics of P450 oxidoreductase: sequence variation in 842 individuals of four ethnicities and activities of 15 missense mutations. (medlineplus.gov)
Isolates3
- Identification of Genetic Variation among Dengue Virus DEN-4 Isolates with Heteroduplex Analysis. (who.int)
- To determine the degree of genetic variation within one serologic group of Venezuelan equine encephalitis virus and the relatedness of viruses with different epidemiologic backgrounds isolated within the same country, virion RNA from 16 isolates belonging to subtype I were compared by RNase T1 oligonucleotide fingerprinting. (ajtmh.org)
- S. zooepidemicus displays a wide genetic variation between different isolates. (cdc.gov)
Common genetic variation2
- Now, a new study suggests that common genetic variation in the gene for catechol-O-methyltransferase (COMT) may modify the cardiovascular benefit of aspirin, and in some people, may confer slight harm. (health.am)
- We conclude that common genetic variation accounts for a substantive proportion of the genetic architecture underlying anxiety. (gale.com)
Influences3
- Alexander, PhD, A., D. Dean III, PhD, and H. H. Goldsmith, PhD. Genetic and Environmental Influences of Variation in Diffusion MRI Measures of White Matter Microstructure . (wisc.edu)
- Additionally, genetic influences on participation in physical activities correlated moderately between adolescence and adulthood (rA = 0.51 95% CI 0.39-0.64 and 0.44 95% CI 0.34-0.55, respectively). (jyu.fi)
- Conclusions Genetic and unique environmental influences explain a large proportion of variation in the number of leisure-time physical activities. (jyu.fi)
Copy number variations1
- The scientists took a high-level view of the entire genome-looking for large deletions and duplications of DNA called copy number variations or CNVs-and found that as many as 41 percent of neurons had at least one unique, massive CNV that arose spontaneously, meaning it wasn't passed down from a parent. (salk.edu)
Differentiation1
- Collectively, this might result in directional changes in additive genetic variation (VA) and trait differentiation (QST) from small to large population size. (datadryad.org)
Proportion1
- Our results suggest that the emerging paradigm of targeting of treatments to the genetic cause in rare devastating epilepsies might also extend to a proportion of common epilepsies. (elsevier.com)
Antigenic1
- Although influenza B viruses have shown more antigenic stability than influenza A viruses, antigenic variation does occur. (cdc.gov)
Human5
- A preliminary study by scientists at the National Institute of Environmental Health Sciences indicates that a human gene variation that reduces production of an enzyme in the lungs also makes people less susceptible to lung cancer. (nih.gov)
- IMSEAR at SEARO: Human genetic variation and personalized medicine. (who.int)
- Agrawal S, Khan F. Human genetic variation and personalized medicine. (who.int)
- Human genome sequencing results revealed an insight into the role of human genetic variation behind differential susceptibility of human diseases, differential response to pharmacological agents and presence of varied phenotypes. (who.int)
- Genetic influence helps explain variation in human fertility. (bvsalud.org)
Trait1
- However, little is known on how genetic and environmental factors affect this trait. (jyu.fi)
Identification1
- Genome-wide association studies should lead to the identification of additional genetic factors underlying cholestatic liver disease. (uzh.ch)
Genome2
- By generating large numbers of knockout lines on a single defined genetic background, these projects aim to uncover the function of every single coding gene in the mouse genome using a high-throughput approach . (taconic.com)
- This array is designed based on the novel variation identified in 642 CAAPA samples of African ancestry with high coverage whole genome sequence data (∼30× depth). (elsevier.com)
Study9
- This study] has identified genetic factors that help determine why some develop glaucoma and others do not, [and] has also provided further evidence that the [TGF-beta] signaling pathway is important in glaucoma pathogenesis," Dr. Fingert said. (medscape.com)
- Nonetheless they note that given that aspirin is preventively prescribed to millions of individuals and the COMT genetic variant is extremely common, this study underscores the potential importance of individualizing therapies based on genetic profiles. (health.am)
- Different substrains of C57BL/6 mice possess unique genetic characteristics that should be considered in study design and in the generation and breeding of genetically engineered animal models. (taconic.com)
- This study established that different sperm from the same male vary in their characteristics because they differ in their genetic cargo. (scitechdaily.com)
- This study examined the effects of genotypic variations on the productivity and behavior of laying hens following heat stress (HS). (usda.gov)
- The Oxford team now hope to carry out a pilot study to see whether tests that look for this type of genetic change can help in the diagnosis of new cases of autism. (technologynetworks.com)
- In this study, we test the hypothesis that variations in this gene influence the development and severity of chronic periodontitis. (muni.cz)
- Methods We did a case-control sequencing study with exome sequence data from unrelated individuals clinically evaluated for one of the two most common epilepsy syndromes: familial genetic generalised epilepsy, or familial or sporadic non-acquired focal epilepsy. (elsevier.com)
- Risk Stratification for Early-Onset Colorectal Cancer Using a Combination of Genetic and Environmental Risk Scores: An International Multi-Center Study. (who.int)
Species3
- Using the model species Arabidopsis thaliana we quantitatively explore the breadth of natural variation in plant hormone responses to three major plant hormones: auxin, cytokinin, and abscisic acid. (biorxiv.org)
- This confirms the genetic closeness of P. mariana and P. rubens species. (scirp.org)
- The morphological species concept does not rely on genetic information to differentiate between members of the same species, and the phylogenetic species concept does. (scienceoxygen.com)
Behavioral2
- Fewell, J & Bertram, SM 2002, ' Evidence for genetic variation in worker task performance by African and European honey bees ', Behavioral Ecology and Sociobiology , vol. 52, no. 4, pp. 318-325. (elsevier.com)
- Like compounds from biological sources and low-molecular-weight nonoccupational asthma, occupational asthma is probably the chemicals cause occupational asthma after a latent period of result of multiple genetic, environmental, and behavioral exposure. (cdc.gov)
Taxa1
- To determine the role of environmental and host genetic factors in shaping fungal endophyte communities we used culturing and metabarcoding techniques to quantify fungal taxa within healthy Scots pine (Pinus sylvestris) needles in a 7-y old provenance-progeny trial replicated at three sites. (reading.ac.uk)
Genomic2
- Washington [US], September 27 (ANI): A novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate cancer has been identified by researchers from Barts Cancer Institute (BCI) at Queen Mary University of London, the Italian Institute for Genomic Medicine, and the University of Milan. (aninews.in)
- We have made the first comprehensive genomic survey of S. aureus in the Philippines, which bridges the gap in genomic data from the Western Pacific Region and will constitute the genetic background for contextualizing prospective surveillance. (who.int)
Determinants1
- The review also incorporates the major findings categorizing the common diseases on the basis of genetic profiles and ethnic information and in establishing personalized disease diagnosis, drug responses and treatment modalities based on the genetic determinants. (who.int)
Sequence1
- One hundred thirteen sequence variations with nine recurrent variant sites were identified in analyzed S-gene sequences compared with the BJ01 strain of SARS-CoV. (cdc.gov)
Diseases1
- Individual variation to protect every being against diseases and infections. (pawpeds.com)
Rare genetic3
- Mutation in a subsegment of chromosome 15 is also known to cause two rare genetic disorders, Angelman and Prader-Willi Syndromes. (disabled-world.com)
- Our research strongly suggests that this type of rare genetic variation is important and accounts for a significant portion of the genetic basis of autism,' says Professor Tony Monaco. (technologynetworks.com)
- We aimed to assess the contribution of ultra-rare genetic variation to common epilepsies. (elsevier.com)
Specific genetic1
- Programs to preserve genetic health in dog breeds have been intensively discussed in Sweden in connection with the development of breed specific genetic strategies. (pawpeds.com)
Different genetic2
- Autism spectrum disorders are a diverse group of disorders characterized by different genetic variations influencing brain development. (disabled-world.com)
- However, early knockout models were produced on a different genetic background, using embryonic stem (ES) cells derived from substrains of inbred 129 mice. (taconic.com)
Analyses1
- Analyses of nongeographic and geographic variation for individuals from 36 localities in Guatemala and southeastern Mexico were conducted to assay morphologic and geographic boundaries. (bioone.org)
COMT1
- Knowing that aspirin is commonly prescribed for the prevention of incident cardiovascular disease, the investigators also wanted to learn if genetic variation in COMT would influence aspirin's potential benefit. (health.am)
Adaptation2
- Balanced variation for the entire population to make long term adaptation to a changing environment possible. (pawpeds.com)
- R. C. Lewontin and L. C. Birch, "Hybridization as a Source of Variation for Adaptation to New Environments," Evolution, Vol. 20, No. 3, 1966, pp. 315-336. (scirp.org)
Makeup3
- It is very variable in its genetic makeup, which makes diagnosis and treatment tricky, as there is not a one size fits all approach for treating patients. (aninews.in)
- The organism's genetic makeup might play a part in the activity of any of these processes and might underlie chemical toxicity and adverse drug reactions ( Meyer, 2000 ). (frontiersin.org)
- Contrary to what we once thought, the genetic makeup of neurons in the brain aren't identical, but are made up of a patchwork of DNA," says corresponding author Fred Gage , Salk's Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease. (salk.edu)
Variance2
- 76% of the variance is heritable and up to 90% is attributable to genetic factors in a broad sense. (jneurosci.org)
- Diversifying or disruptive selection increases genetic variance when natural selection selects for two or more extreme phenotypes that each have specific advantages. (scienceoxygen.com)
Important genetic1
- Washington [US], October 1 (ANI): A group of researchers discovered a novel role for a cancer-causing gene in controlling an important genetic process that underpins genetic variation in prostate cancer . (aninews.in)
Investigators1
- The investigators identified genetic variations associated with POAG, including NPG. (medscape.com)
Factors4
- In the future, when more environmental and genetic factors (like CDKN2BAS ) are discovered, physicians may be able to use genetic tests to accurately predict who is at greatest risk for developing glaucoma and target treatments to those who need them most," Dr. Fingert concluded. (medscape.com)
- Factors that influence the variation in occurrence of antipsychotic-related parkinsonism in elderly have not been well elucidated. (eur.nl)
- The factors causing variation in birth date and birth weight were analysed from the data from an experimental reindeer herd consisting of 1136 calves with parental information. (uit.no)
- Cancer is a multifactorial disease brought on by a combination of causal and predisposing genetic factors, and which at a given moment and under favorable conditions may take effect in predisposed people 1 . (bvsalud.org)
Pinus1
- Stabilité phénotypique de la croissance en hauteur et cinétique journalière de la presson de sève et de la transpiration chez le pin maritime ( Pinus pinaster Ait. (afs-journal.org)
Person's1
- What causes this malfunction is unclear, but researchers have identified some genetic variations that may increase a person's risk. (medlineplus.gov)
Behaviors1
- New research offers a better understanding of how natural genetic variation impacts brain development, gives rise to the spectrum of behaviors associated with autism and may contribute to more individualized approaches for supporting people with autism. (disabled-world.com)
Cardiovascular1
- When we examined women in the placebo arm of the trial, we found that the 23 percent of the women who were 'val/vals' were naturally protected against incident cardiovascular disease," explains senior author Daniel I. Chasman, PhD, a genetic epidemiologist in the Division of Preventive Medicine at Brigham and Women's Hospital and Associate Professor of Medicine at Harvard Medical School. (health.am)
Patterns1
- Relationships were estimated using the resulting data from the patterns of allozyme variation and summarized in both phenetic and cladistic branching diagrams. (unl.edu)
Population5
- The Collaborative Cross (CC) mouse reference population is a promising model for pharmacogenomic studies because of its large amount of genetic variation, genetic reproducibility, and dense recombination sites. (frontiersin.org)
- Genetic drift might furthermore overcome selection as population size decreases. (datadryad.org)
- What is most likely happening to the genetic variation of the population of North East Arctic cod? (scienceoxygen.com)
- The genetic variation in the population is decreasing due to selective pressure. (scienceoxygen.com)
- The MRSA population in the Philippines comprised a limited number of genetic clones, including several international epidemic clones, such as CC30-spa-t019-SCCmec-IV-PVL+, CC5-SCCmec-typeIV and ST239-spa-t030-SCCmec-typeIII. (who.int)
Disorders3
- The cause of inherited disorders - observed in so many dog breeds - is that breeders, due to ignorance or extreme breeding forced by various forms of competition trials, break down the protective barriers against genetic disorders that Nature has built over millions of years by means of natural selection. (pawpeds.com)
- Thus everybody involved in breeding ought to know at least a little bit about how the fertilized egg is protected against genetic disorders. (pawpeds.com)
- Autism spectrum disorders are known to have a predominantly genetic basis from twin and family studies, but the genetic changes responsible are varied and remain largely unknown. (technologynetworks.com)
Parameters1
- Genetic parameters and QTL analysis of delta C-13 and ring width in maritime pine. (afs-journal.org)
Research3
- Genetically engineered animal models (GEMs) are powerful tools for biomedical research and drug discovery, but genetic variation in animal models derived from distinct ES cell lines and subsequent breeding can impact both the interpretation and reproducibility of studies which employ them 1 . (taconic.com)
- A central challenge in pharmaceutical research is to investigate genetic variation in response to drugs. (frontiersin.org)
- Overall an attempt has been made to highlight the importance of studying the genetic profiles of an individual in biomedical and pharmacogenomics research. (who.int)
Evidence1
- The data provide evidence that genetic selection is a useful strategy for reducing HS response in laying hens. (usda.gov)
Autism2
- By identifying the genetic causes of autism, we hope in the future to be able to improve the diagnosis and treatment of this condition which can affect children and their families so severely. (technologynetworks.com)
- Many of the lost or duplicated DNA chunks occurred in genetic regions already implicated in autism. (technologynetworks.com)
Researchers1
- While recent advances in gene editing accelerated the migration of models to a pure C57BL/6 background, researchers should remain aware of potentially confounding results from genetic variation between C57BL/6 substrains. (taconic.com)
Studies3
- Dr. Wiggs and coworkers have conducted one of the world's largest genetic studies of glaucoma," Dr. Fingert said. (medscape.com)
- A We will store part of the blood sample that we collect in the exam center for future genetic studies. (cdc.gov)
- What genetic studies will be done with the samples? (cdc.gov)
Suggests1
- This finding, along with the fact that the neurons had unique CNVs, suggests that the genetic changes occur later in development and are not inherited from parents or passed to offspring. (salk.edu)
Substantial1
- However, while there is substantial natural variation of root architectures, it is not clear to which extent genetic variation in hormone related pathways contribute. (biorxiv.org)