Genetic Markers: A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.Biological Markers: Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.Microsatellite Repeats: A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).Chromosome Mapping: Any method used for determining the location of and relative distances between genes on a chromosome.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Genetic Linkage: The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.Alleles: Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Polymorphism, Genetic: The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.Genetic Variation: Genotypic differences observed among individuals in a population.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Models, Genetic: Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.Sequence Analysis, DNA: A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.Polymerase Chain Reaction: In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.Gene Frequency: The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.Haplotypes: The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.Genetics, Population: The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.Phenotype: The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.Polymorphism, Restriction Fragment Length: Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.Quantitative Trait Loci: Genetic loci associated with a QUANTITATIVE TRAIT.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Crosses, Genetic: Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Linkage Disequilibrium: Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.Recombination, Genetic: Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.Pedigree: The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.Physical Chromosome Mapping: Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)Genome-Wide Association Study: An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.DNA Primers: Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.HLA-B15 Antigen: A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.Expressed Sequence Tags: Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.Quantitative Trait, Heritable: A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)DNA, Mitochondrial: Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.Case-Control Studies: Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.DNA, Bacterial: Deoxyribonucleic acid that makes up the genetic material of bacteria.Resedaceae: A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. It is a small family of herbs and shrubs. Some produce GLUCOSINOLATES.Paternity: Establishing the father relationship of a man and a child.Breeding: The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.Hybridization, Genetic: The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.Genetic Loci: Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.Water Pollution: Contamination of bodies of water (such as LAKES; RIVERS; SEAS; and GROUNDWATER.)Genome, Plant: The genetic complement of a plant (PLANTS) as represented in its DNA.Lod Score: The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."DNA, Plant: Deoxyribonucleic acid that makes up the genetic material of plants.Heterozygote: An individual having different alleles at one or more loci regarding a specific character.Amplified Fragment Length Polymorphism Analysis: The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.Inbreeding: The mating of plants or non-human animals which are closely related genetically.Geography: The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)Dinucleotide Repeats: The most common of the microsatellite tandem repeats (MICROSATELLITE REPEATS) dispersed in the euchromatic arms of chromosomes. They consist of two nucleotides repeated in tandem; guanine and thymine, (GT)n, is the most frequently seen.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Phylogeography: A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)Likelihood Functions: Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.Bayes Theorem: A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.Random Amplified Polymorphic DNA Technique: Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.Gene Flow: The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.Chromosomes, Artificial, Bacterial: DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.Minisatellite Repeats: Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.Sequence Tagged Sites: Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.Contig Mapping: Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.Tandem Repeat Sequences: Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).Cattle: Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.Transformation, Genetic: Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.Cluster Analysis: A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.Genome: The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.Blood Group Antigens: Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Models, Statistical: Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.Genetic Diseases, Inborn: Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.Wolves: Any of several large carnivorous mammals of the family CANIDAE that usually hunt in packs.Chromosomes, Bacterial: Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.Chromosomes, Plant: Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.Genes, Plant: The functional hereditary units of PLANTS.Genetic Association Studies: The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease.Genes, Dominant: Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Genotyping Techniques: Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).Heterozygote Detection: Identification of genetic carriers for a given trait.Vaccines, Marker: Vaccines used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. Marker vaccines can be either a subunit or a gene-deleted vaccine.Immunoglobulin Gm Allotypes: Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)DNA Fingerprinting: A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Software: Sequential operating programs and data which instruct the functioning of a digital computer.INDEL Mutation: A mutation named with the blend of insertion and deletion. It refers to a length difference between two ALLELES where it is unknowable if the difference was originally caused by a SEQUENCE INSERTION or by a SEQUENCE DELETION. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a FRAMESHIFT MUTATION.Genes: A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.Genetic Testing: Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.Bacteroidetes: A phylum of bacteria comprised of three classes: Bacteroides, Flavobacteria, and Sphingobacteria.Genomics: The systematic study of the complete DNA sequences (GENOME) of organisms.DNA, Protozoan: Deoxyribonucleic acid that makes up the genetic material of protozoa.Risk Factors: An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.Molecular Epidemiology: The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.Selection, Genetic: Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.HLA Antigens: Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.Cell Differentiation: Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.Homozygote: An individual in which both alleles at a given locus are identical.Immunoglobulin Allotypes: Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.Digitalis: A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.DNA Transposable Elements: Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Repetitive Sequences, Nucleic Acid: Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).Genetics: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Hybrid Cells: Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.Pharmacogenetics: A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).DNA, Satellite: Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Karyotyping: Mapping of the KARYOTYPE of a cell.Cloning, Molecular: The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Oncorhynchus: A genus of the family SALMONIDAE (salmons and trouts). They are named for their hooked (onco) nose (rhynchus). They are usually anadromous and occasionally inhabit freshwater. They can be found in North Pacific coastal areas from Japan to California and adjacent parts of the Arctic Ocean. Salmon and trout are popular game and food fish. Various species figure heavily in genetic, metabolism, and hormone research.Fiducial Markers: Materials used as reference points for imaging studies.Predictive Value of Tests: In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.DNA, Ribosomal: DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.Genetic Drift: The fluctuation of the ALLELE FREQUENCY from one generation to the next.Rh-Hr Blood-Group System: Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.Nuclear Family: A family composed of spouses and their children.Asian Continental Ancestry Group: Individuals whose ancestral origins are in the southeastern and eastern areas of the Asian continent.Blotting, Southern: A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.Gene Library: A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.Computational Biology: A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.Molecular Biology: A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.Chromosomes, Human, Pair 1: A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.Chromosomes: In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Reverse Transcriptase Polymerase Chain Reaction: A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.Crossing Over, Genetic: The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.Nucleic Acid Hybridization: Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)Nidovirales: An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.Hip Dysplasia, Canine: A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.Forensic Genetics: The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.DNA Restriction Enzymes: Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.Restriction Mapping: Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.In Situ Hybridization, Fluorescence: A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.Gene Pool: The total genetic information possessed by the reproductive members of a POPULATION of sexually reproducing organisms.Diploidy: The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Feces: Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.Nuchal Cord: A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.Genealogy and HeraldryGenes, Bacterial: The functional hereditary units of BACTERIA.Genome, Mitochondrial: The genetic complement of MITOCHONDRIA as represented in their DNA.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Animals, Domestic: Animals which have become adapted through breeding in captivity to a life intimately associated with humans. They include animals domesticated by humans to live and breed in a tame condition on farms or ranches for economic reasons, including LIVESTOCK (specifically CATTLE; SHEEP; HORSES; etc.), POULTRY; and those raised or kept for pleasure and companionship, e.g., PETS; or specifically DOGS; CATS; etc.Y Chromosome: The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.DNA, Ribosomal Spacer: The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).Azaguanine: One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.Drug Resistance: Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.Epistasis, Genetic: A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.Genetic Techniques: Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.Sequence Alignment: The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.Genes, Mitochondrial: Genes that are located on the MITOCHONDRIAL DNA. Mitochondrial inheritance is often referred to as maternal inheritance but should be differentiated from maternal inheritance that is transmitted chromosomally.Genetics, Microbial: A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.Data Interpretation, Statistical: Application of statistical procedures to analyze specific observed or assumed facts from a particular study.Oryza sativa: Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.Chimera: An individual that contains cell populations derived from different zygotes.Deoxyribonucleases, Type II Site-Specific: Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.Plasmodium vivax: A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.HLA-DQ Antigens: A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.China: A country spanning from central Asia to the Pacific Ocean.Bacterial Typing Techniques: Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.Immunoglobulin Km Allotypes: Allelic variants of the kappa light chains (IMMUNOGLOBULIN KAPPA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN LIGHT CHAIN GENES.EuropeTunisia: A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.HLA-DR Antigens: A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Immunogenetics: A subdiscipline of genetics which deals with the genetic basis of the immune response (IMMUNITY).Chromosomes, Human, Pair 8: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Chromosome Aberrations: Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.Genomic Library: A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).Prostatic Neoplasms: Tumors or cancer of the PROSTATE.HLA-B Antigens: Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.Chromosomes, Human, Pair 16: A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Chromosomes, Human, Y: The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.Real-Time Polymerase Chain Reaction: Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.Breast Neoplasms: Tumors or cancer of the human BREAST.DNA Probes: Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.Chromosomes, Human: Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.Mice, Inbred Strains: Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.Chromosomes, Human, Pair 6: A specific pair GROUP C CHROMSOMES of the human chromosome classification.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Chromosomes, Human, Pair 7: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Disease Susceptibility: A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.Probability: The study of chance processes or the relative frequency characterizing a chance process.Chromosomes, Human, Pair 11: A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.Forsythia: A plant genus of the family OLEACEAE. Members contain suspensaside.Transcriptome: The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Principal Component Analysis: Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.User-Computer Interface: The portion of an interactive computer program that issues messages to and receives commands from a user.Streptomycin: An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.

11q23.1 and 11q25-qter YACs suppress tumour growth in vivo. (1/12529)

Frequent allelic deletion at chromosome 11q22-q23.1 has been described in breast cancer and a number of other malignancies, suggesting putative tumour suppressor gene(s) within the approximately 8 Mb deleted region. In addition, we recently described another locus, at the 11q25-qter region, frequently deleted in breast cancer, suggesting additional tumour suppressor gene(s) in this approximately 2 Mb deleted region. An 11q YAC contig was accessed and three YACs, one containing the candidate gene ATM at 11q23.1, and two contiguous YACs (overlapping for approximately 400-600 kb) overlying most of the 11q25 deleted region, were retrofitted with a G418 resistance marker and transfected into murine A9 fibrosarcoma cells. Selected A9 transfectant clones (and control untransfected and 'irrelevant' alphoid YAC transfectant A9 clones) were assayed for in vivo tumorigenicity in athymic female Balb c-nu/nu mice. All the 11q YAC transfectant clones demonstrated significant tumour suppression compared to the control untransfected and 'irrelevant' YAC transfected A9 cells. These results define two discrete tumour suppressor loci on chromosome 11q by functional complementation, one to a approximately 1.2 Mb region on 11q23.1 (containing the ATM locus) and another to a approximately 400-600 kb subterminal region on 11q25-qter.  (+info)

Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. (2/12529)

The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with longterm follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma.  (+info)

Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. (3/12529)

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. (4/12529)

The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.  (+info)

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. (5/12529)

p73, a novel p53 family member, is a recently identified candidate neuroblastoma (NBL) suppressor gene mapped at chromosome 1p36.33 and was found to inhibit growth and induce apoptosis in cell lines. To test the hypothesis that p73 is a NBL suppressor gene, we analysed the p73 gene in primary human NBLs. Loss of heterozygosity (LOH) for p73 was observed in 19% (28/151) of informative cases which included 92 mass-screening (MS) tumors. The high frequency of p73 LOH was significantly associated with sporadic NBLs (9% vs 34%, P<0.001), N-myc amplification (10% vs 71%, P<0.001), and advanced stage (14% vs 28%, P<0.05). Both p73alpha and p73beta transcripts were detectable in only 46 of 134 (34%) NBLs at low levels by RT-PCR methods, while they were easily detectable in most breast cancers and colorectal cancers under the same conditions. They found no correlation between p73 LOH and its expression levels (P>0.1). We found two mutations out of 140 NBLs, one somatic and one germline, which result in amino acid substitutions in the C-terminal region of p73 which may affect transactivation functions, though, in the same tumor samples, no mutation of the p53 gene was observed as reported previously. These results suggest that allelic loss of the p73 gene may be a later event in NBL tumorigenesis. However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.  (+info)

High polymorphism level of genomic sequences flanking insertion sites of human endogenous retroviral long terminal repeats. (6/12529)

The polymorphism at the multitude of loci adjacent to human endogenous retrovirus long terminal repeats (LTRs) was analyzed by a technique for whole genome differential display based on the PCR suppression effect that provides selective amplification and display of genomic sequences flanking interspersed repeated elements. This strategy is simple, target-specific, requires a small amount of DNA and provides reproducible and highly informative data. The average frequency of polymorphism observed in the vicinity of the LTR insertion sites was found to be about 12%. The high incidence of polymorphism within the LTR flanks together with the frequent location of LTRs near genes makes the LTR loci a useful source of polymorphic markers for gene mapping.  (+info)

Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. (7/12529)

BACKGROUND: cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. AIM: To characterise cagA and the cag PAI in Japanese H pylori strains. METHODS: H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. RESULTS: All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. Details of the PAI of these strains were checked; three lacked cagB to cagQ (cagI) and continuously cagS to cag13 (cagII), and the remaining one lacked cagB to cag8. Western cagA negative strains completely lacked cag PAI including cagA. Nucleotide sequence analysis in one strain in which the cag PAI was partially deleted showed that the partial deletion contained 25 kb of cag PAI and the cagA promoter. Interleukin-8 induction was lower with the cag PAI partial deletion strains than with the intact ones. All Japanese cag PAI deleted strains were derived from patients with non-ulcer dyspepsia, whereas 41 of 59 (70%) CagA-producing strains were from patients with peptic ulcers or gastric cancer (p<0.05). CONCLUSIONS: Most Japanese H pylori strains had the intact cag PAI. However, some lacked most of the cag PAI in spite of the presence of cagA. Thus the presence of the cagA gene is not an invariable marker of cag PAI related virulence in Japanese strains.  (+info)

Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis? (8/12529)

BACKGROUND: In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS: To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS: Leucocyte DNA was prepared from 23 patients with chronic alcoholic pancreatitis, 21 with alcoholic liver cirrhosis, 34 individuals from seven independent families with hereditary pancreatitis, and 15 healthy controls. DNA was also obtained from pancreatic tissue (n=7) and from pancreatic juice (n=5) of patients suffering from chronic alcoholic pancreatitis. R117H was detected by restriction digestion with Afl III. N21I was identified by an allele specific polymerase chain reaction (PCR). RESULTS: R117H was detected in four families with hereditary pancreatitis. The N21I mutation was identified in three families. All mutations were confirmed by sequencing of the corresponding DNAs. In patients with chronic alcoholic pancreatitis neither the exon 2 nor exon 3 mutations were present in blood leucocytes, pancreatic juice, or pancreatic tissue. DNA of the patients with alcoholic liver cirrhosis as well as all controls was of wild type. CONCLUSIONS: The allele specific PCR may be used to screen for the N21I mutation of cationic trypsinogen. Both trypsinogen mutations were found in hereditary pancreatitis but do not seem to be major pathogenic factors in chronic alcoholic pancreatitis.  (+info)

Simple Sequence Length Polymorphisms (SSLPs) are used as genetic markers with polymerase chain reaction (PCR). An SSLP is a type of polymorphism: a difference in DNA sequence amongst individuals. SSLPs are repeated sequences over varying base lengths in intergenic regions of deoxyribonucleic acid (DNA). Variance in the length of SSLPs can be used to understand genetic variation between two individuals in a certain species. An example of the usage of SSLPs (microsatellites) is seen in a study by Rosenberg et al., where SSLPs were used to cluster different continental races. The study was critical to Nicholas Wades New York Times Bestseller, Before the Dawn: Recovering the Lost History of Our Ancestors. Rosenberg studied 377 SSLPs in 1000 people in 52 different regions of the world. By using PCR and cluster analysis, Rosenberg was able to group individuals that had the same SSLPs . These SSLPs were extremely useful to the experiment because they do not affect the phenotypes of the individuals, ...
A population size of 100 was simulated for 10 biallelic or multiallelic marker loci for 100 generations before pedigree recording. In each generation, the number of male and female parents was 50 and their alleles were transmitted to descendants on the basis of Mendelian segregation using the gene-dropping method (MacCluer et al. 1986). Parents were randomly mated with a total of two offspring for each of 50 mating pairs. In the multiallelic marker model (e.g., microsatellites), the number of alleles assumed in each marker locus was 4 and base allele frequencies were all at 0.25. In the biallelic marker model (e.g., SNP), the number of alleles was 2 and starting allele frequencies were 0.5. The marker alleles were mutated at rates of 4 × 10−4 per generation in multiallelic markers (Dallas 1992; Weber and Wong 1993; Ellegren 1995) and 2.5 × 10−8 per generation in biallelic markers (Nachman and Crowell 2000). A mutated locus was switched between the two existing alleles for biallelic markers ...
A linkage map of cacao based on codominant markers has been constructed by integrating 201 new simple sequence repeats (SSR) developed in this study with a number of isoenzymes, restriction fragment...
The HCP5 genetic marker was not a good predictor of quitting abacavir, perhaps because the study considered stopping abacavir for any reason, not just the hypersensitivity reaction, and because people in Switzerland started getting HLA-B*5701 screening before beginning abacavir during this period. For the other four drugs, hazard ratios adjusted for other risk factors found that genetic markers independently predicted stopping efavirenz (adjusted hazard ratio [aHR] 3.10, 95% confidence interval [CI] 1.48 to 6.46, P = 2.59 x 10(-3) and atazanavir (aHR 7.31, 95% CI 2.86 to 18.72, P = 3.30 x 10(-6)). There was a strong trend toward an independent effect of genetic markers on quitting tenofovir (aHR 2.30, 95% CI 0.99 to 5.31, P = 0.052) but not lopinavir (aHR 1.42, 95% CI 0.62 to 3.25, P = 0.41 ...
Breeding technique allows farmers to conventionally breed plants based on genetic markers; GMOs are unnecessary, costly, dangerous and now obsolete
An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific journals.
Detail záznamu - An Improved Consensus Linkage Map of Barley Based on Flow-Sorted Chromosomes and Single Nucleotide Polymorphism Markers - Detail záznamu - Knihovna Akademie věd České republiky
A specific sequence of DNA at a known location on a chromosome. There are many genetic markers on each chromosome. Genetic markers and genes that are close to each other on a chromosome are usually inherited (passed from parent to child) together. This may help researchers find a gene near a marker that may cause a certain disease or trait within a family. Examples of genetic markers are single polymorphism nucleotides (SNPs) and microsatellites ...
Genome informatics company Cypher Genomics, Inc. will use its diagnostics technology to assist Celgene in discovering novel genomic biomarkers that identify patients who respond well to specific drugs. The collaboration comes during industrys push in increasing efforts in precision medicine, tailoring therapy based on a patients genetic makeup. The companies announced …. ...
Woman jailed in granddaughters slaying ruled sane in 2015 - AP News: LOS ANGELES (AP) - A California woman suspected of fatally .12/18/2017 18:39:01PM EST.
Jack Banda of Marshfield watched his daughter, Nicole Puzzo, struggle to carry his granddaughter, Stella, onto the beach. Stella, now four, has cerebral palsy. A retired engineer, Banda designed a child-size
Dallas Green speaks about his 9-year-old granddaughter, Christina Taylor Green, who was a victim in the Arizona shooting tragedy last month. - Philly.com, Philadelphia Philly.com
Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package o ers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package ...
Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. In phase l, the plan isto describe a method to identify large-numbers of the new markers and to isolate and characterizeseveral examples. In addition, the basic expectations that they will produce precise amplificationproducts and that their allelic content can be determined more efficiently, safely, and cheaply than othersystems will be demonstrated. This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large number of the markers, more thorough ...
A summary of the results for AFLP, SNP, and microsatellite data sets in Tables 3-5⇑ is shown. The PPV is defined as the proportion of markers detected as being under selection that are correctly classified. Results are presented using cutoff values that lead to a 5% total false-positive rate for both the reversible-jump (RJ) method introduced here and the informal criterion (IC) originally proposed by Beaumont and Balding (2004). ...
Trans2K® DNA Marker,DNA markers,DNA Molecular Weight Standards,Products,Beijing TransGen Biotech Co.Ltd,OverviewContents& storageCitations & referencesRelated ImagesDownloadOverviewDescriptionTrans2K® DNA Marker is a premixed, ready-to-load
Blank lines in the input file are ignored. The file is organized in several fields separated by one or more space or TAB characters. The first non-blank line gives the start position of the DNA fragment to be drawn after the keyword Start. The end position is on the second line following the keyword End. Then, one or more groups (up to a maximum of 20) of genetic markers are defined. Each group begins with a line consisting of the keyword group and ends with a line consisting of the keyword endgroup. If desired, a group name can be given on the very next line but will not be displayed (only for compatibilty with lindna). Next, the individual markers (up to a maximum of 1000) of the group are described. Each marker begins with a line consisting of the keyword label and ends with a line consisting of the keyword endlabel. Do not start a new marker (by using a label line) before you have closed the previous marker (by using an endlabel line). You must end a previous marker ...
Blank lines in the input file are ignored. The file is organized in several fields separated by one or more space or TAB characters. The first non-blank line gives the start position of the DNA fragment to be drawn after the keyword Start. The end position is on the second line following the keyword End. Then, one or more groups (up to a maximum of 20) of genetic markers are defined. Each group begins with a line consisting of the keyword group and ends with a line consisting of the keyword endgroup. If desired, a group name can be given on the very next line but will not be displayed (only for compatibilty with lindna). Next, the individual markers (up to a maximum of 1000) of the group are described. Each marker begins with a line consisting of the keyword label and ends with a line consisting of the keyword endlabel. Do not start a new marker (by using a label line) before you have closed the previous marker (by using an endlabel line). You must end a previous marker ...
It can be described as some sort of variation present can arise due to mutation or alteration in the genomic loci that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (SNP), or a long one, like microsatellites. Some commonly used types of genetic markers are RFLP, VNTR, Microsatellite Polymorphism, SNP, STR ...
reference to the John Coltrane composition Mr. P.C. The song was written for Paul Chambers, Tranes long-time bassist, and I realized last night how much Chambers is the star of that piece, driving everyone in the band to perform fabulous solos without being featured himself. Thats a jazz thing. That is exactly what Nan did each week with her solid devotion to me and my colleagues: she pushed the music along, influencing us without getting in the way. Nan fell by the station for a visit once when her granddaughter was in town from California. Nan was dressed like Norma Desmond, with black sunglasses and a brocade wrap around her head. I know she was training her granddaughter to listen to jazz by insisting on the outing. The two of them sat quietly in the studio and watched me program the entire afternoon. From then on, the weekly letters not only included stories from Nans active memory and tales of her daily activities, Nan also kept me apprised of the goings on of her beloved granddaughter. ...
Trans2K® Plus II DNA Marker,DNA markers,DNA Molecular Weight Standards,Products,Beijing TransGen Biotech Co.Ltd,OverviewContents& storageCitations & referencesRelated ImagesDownloadOverviewDescriptionTrans2K® Plus II DNA Marker is a premixed
A fragment of genetic material associated with a certain location in the genome is known as molecular marker. Molecular markers have been useful in determining hybrid purity, identifying genotypes, discovering genes linked to known markers and also enable an in-depth analysis of quantitative traits, allowing interesting alleles to be found in wild or cultivated germplasm. Due to its heritability and relatively easy to assay, made DNA based markers more advantageous than the other markers. The predominate sequence based markers like Single Nucleotide Polymorphisms (SNPs), Simple Sequence Repeats (SSRs) and high throughput DArT assays are widely used in the genetic analysis.. This portal provides the convenient link to molecular marker resources which are identified and validated by IBP partners and collaborators or available in public domain to make easier to the researchers.. To access Molecular resources, click on the appropriate area in the sidebar on the left. For additional information and ...
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy ...
Rheenen, H A van and Moss, J P and Kapoor, R K and Seetharama, N and Davies, D R and Ellis, T H N and Poyser, S and Loader, P A and Knox, M (1996) The development and exploitation of novel genetic markers in the improvement of chickpea and pigeonpea. Project Report. DFID, UK. ...
The largest gene-probing study ever done has fished out dozens of new genetic markers that flag a person's susceptibility to breast, ovarian and
The largest gene-probing study ever done has fished out dozens of new genetic markers that flag a person's susceptibility to breast, ovarian and
beginning-of-information marker вчт. маркер начала информации beginning-of-tape marker вчт. маркер начала ленты boundary marker ограничительный знак marker закладка (в книге) marker клеймовщик; клеймовщица marker клеймовщик marker школ. лицо, отмечающее присутствующих учеников; преподаватель, проверяющий письменные работы marker вчт. маркер marker маркер marker горн. маркирующий горизонт; not a marker to (или on) разг. ничто по сравнению с; = в подметки не годится marker маркер marker амер. мемориальная доска marker горн. маркирующий горизонт; not a marker to (или on) разг. ничто по сравнению с; = в подметки не ...
I cant believe the hatchet job mainstream reporting does on the effectiveness and safety of nutritional supplements. The idea of health and illness is very complicated, which these reports seldom acknowledge. Just like prescribed drugs, not everything is going to work for every person. If fact, the newest research is on genetic markers showing whether or not new drugs will work on the individual person. Medicine knows there are many cofactors that go hand in hand with any illness as well as usefulness of medications. Id add supplements to the list.. As for genetics, something has to flip the genetic switch for illness to happen. The thing that flips or stops the switch is called a cofactor. As for the role of the dice, chance does come into play, but cofactors are a big player as well. Here are some examples according to Julian Whittaker, MD. He says in his newsletter that if everyone 65 and older took calcium and vitamin D, about 776,000 hospitalizations for hip fractures could be avoided. He ...
Date: January 28, 2021 Time: 7:00am (PST), 10:00am (EST) Many of the newly recognized clinically significant genetic markers in pediatric leukemias cannot be reliably detected by routine dia
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Only ~50% of the SNPs detected using raw data coincide between SMA and Blossoc methods. This percentage increased to 67% when using corrected data. The disagreement between the corrected methods was due to 4 SNPs: SNP 331 was detected with SMA (QxPak). This SNP showed high LD with SNP 402 (D ≈ 1, r2 = 0.3), which was highly associated with the phenotype. The equivalent SNP in the SMA raw (323) showed low BPP (0.1). Therefore, SNP 331 is probably a false positive. SNP 3952 was detected with Blossoc and also with SMA raw (BPP = 0.99), suggesting that it is a true QTL. The SNP identified in the beginning of Chromosome 3 (2133) by the SMA method (BPP = 0.89) was also detected with Blossoc on raw data, but was not selected with Blossoc on corrected data. This SNP showed a well defined peak with corrected Blossoc, close to the significance threshold (HQ = 13). Therefore, SNP 2133 is probably also a true QTL. These results indicate that the thresholds defined here for both SMA and Blossoc on ...
This article takes a quantitative approach to the grammar of English two-part discourse marker sequences like oh well, you know I mean, etc. We investigate the internal ordering preferences of such sequences in spoken American English corpus data from the perspective of grammaticalization. From this perspective, the development of many discourse markers can be understood as involving a process of increasing syntactic de-categorialization (Hopper 1991) as the grammaticalizing element loses its original grammatical constraints and comes to function as a marker at the level of discourse. We test the hypothesis that discourse marker grammaticalization results in largely unconstrained ordering possibilities. Our analysis shows that, on the contrary, discourse marker sequencing is highly constrained. We interpret these constraints in terms of Auers (1996) model of discourse marker grammaticalization. Discourse marker sequencing is characterized by strong persistence of a markers original syntactic category
The study, published in the February issue of the American Journal of Human Genetics, involved 3,636 people enrolled in a large trial on the genetics of hypertension. To see whether genetic markers correspond to the standard racial categories, the scientists first analyzed the volunteers DNA, identifying which genetic markers they carried. They then used a computer program to cluster people based on genetic similarities; those who shared genetic markers were grouped together. Finally, the scientists compared those groupings with the volunteers self-identified race. The result: people who considered themselves white had been grouped by the computer, based on their genetic markers, in one cluster, while people who consider themselves African-American had been grouped in a second, different cluster ...
This is the first recorded adventure featuring James Allenvale Bunduki Gunn, the second adopted son of Tarzan, Lord Greystoke. Dawn Drummond-Clayton, the granddaughter of John Korak Drummond-Clayton, is also featured. Story by J.T. Edson in J.T.s Hundredth. 1972 DEATH TO SIMBA NYUSE This is the first recorded adventure of Dawn Drummond-Clayton, the daughter of Armand John and Hazel Drummond-Clayton, and the granddaughter of John Korak Drummond-Clayton. There is also a reference to Sanders of the River. Story by J.T. Edson in J.T.s Ladies. John Korak Drummond-Clayton was the first adopted son of Tarzan and the biological brother of Hugh Bulldog Drummond. The Sanders of the River series was written by Edgar Wallace. November 1972 - The Godwulf Manuscript, the first recorded case of Boston private eye Spenser, as narrated by Spenser and edited by Robert B. Parker. Spenser is the nephew of Philip Marlowe. May 1973 - Policeman Neil Howie travels to the Scottish isle of Summerisle to solve ...
Another thing that was not helpful was my co-worker bursting into the cubicle where I was talking with a colleague and waving around the card she got for the birth of her granddaughter, which featured a disturbing photo of a babys head being held by two hands, taken from the top of the head (Note to everyone I know: If I ever find myself holding a baby that is mine and am lucky enough to get a congratulations card from you, please do not pick the one featuring one or more babies in unnatural or vaguely humiliating positions or outfits. This includes being dressed up like flowers or animals. This practice is not okay and to my mind should be banned by law.). Im not sure what her point was in showing this to us, although my sensitive/vaguely human side does see that one might be excited about a granddaughter. But still. I just really, really do not need to be reminded about my infertility while Im at work trying to forget about it. Can we all agree to that? Yeah, thanks ...
article{b12300dc-2501-4695-a587-8e7248e6b8db, author = {Bjartell, Anders}, issn = {1873-7560}, language = {eng}, pages = {29--31}, publisher = {Elsevier}, series = {European Urology}, title = {Genetic Markers and the Risk of Developing Prostate Cancer.}, url = {http://dx.doi.org/10.1016/j.eururo.2011.03.005}, volume = {60}, year = {2011 ...
The cagefighter looked excited, but exhausted, as he welcomed his parents Carol and Bob to the Essex home he shares with fiancée Chantelle Houghton.
2 Answers (question resolved) - Posted in: oxygen, baby - Answer: The doctor would have known the baby was in distress long before the 6 hr ...
As mentioned elsewhere in this document, in the clinical research process and assistance it will be essential the use of genetic biomarkers, this will allow to generate drugs for groups of patients (stratification) or in some cases individualization. For the current Clinical Test concept, knowledge of the genetic profile can help to avoid interactions with other drugs. From the assistance point of view it is essential to generate an assistance model that stratifies / personalizes the prescription. Among the genetic markers, those that determine the metabolic capacity are the most studied and those most included in the regulation framework. However, one of the great problems is the extrapolation of the phenotype data from the genotype, therefore, it is necessary to generate a new algorithm that allows qualitative information to be transformed into quantitative information, something that can be done from the existing data in the literature and that generated within the project. The possibility of ...
University of Chicago researchers said they have identified a genetic marker that will help identify children who are most likely to develop asthma after they catch a cold
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markers - MedHelps markers Center for Information, Symptoms, Resources, Treatments and Tools for markers. Find markers information, treatments for markers and markers symptoms.
Etc. [34, 35]. However, it still remains challenging to identify one single marker or several combined markers to specifically identify all the CSCs in ovarian tumor, and the exact roles of these `stemness related markers, are still poorly understood due to either a current lack of understanding...
Director of USDA Central Small Grain Genotyping Lab, Guihua Bai turns the spotlight on to the wonderful world of wheat and DNA markers
My name is Angela, though I prefer to be called Abbey (a long story for another time). I am 39, have 2 children, 2 granddaughters, an amazing husband and live in Wollongong, Australia. I have never been 100% happy with the way I look and feel but have only ever put in 60% effort to change it. That all stopped less than 3 weeks ago. 18 days ago while scrolling through Facebook, a post appeared and curiosity got the better of me so I clicked the link to check it out and it led me halfway here, to the start of my brand new mindset. For under $50 I thought this program was worth a try. After an easy download I got right into reading and started the program the next day (with trepidation). After the first day I was astounded. I wasnt hungry at all, I had no cravings, and with the addition of fruit and healthy fats I felt as though I was cheating (not too many plans allow this). I am now 3 days short of finishing the 21 Day program and my brand new mindset hasnt changed, I am still astounded. My ...
I get to meet a lot of different people, Cox said. I have lived in the area since 1972, but only in the last 5 years I have seen the community in a different way by having my own business. I like the people. I like going to different places, that can be fun or interesting. I even had my granddaughter with me one time. He said he does not repair windows, but he will help with information on repairing windows or other things in the home to get the help that is needed. I like to see businesses sprout up that are home-owned businesses, Cox said ...
So . . . spring has passed and we are in the throes of an early and hot summer here on the West Coast. Just a few miles from us in Ojai, temperatures were as high as 110 degrees. Closer in, the temperatures were in the high 80s - breaking one record here and one in Oxnard. Ive been home for nearly 3 weeks now, yet this is my first post this month. As all moves go, we ran into some snags. My friends van was not electrically ready for to tow a trailer, even though all the wiring was there. Result: we rented a truck. Of course it was more money than I was prepared for and I had to rent a car to send them home. Shes handicapped and access on planes or trains is just not right for.. I left a few things up north that I will have to collect when I go for my next visit up there. Id go now if I could, but finances will not allow. Besides, there are wildfires burning and my daughters and granddaughter are in danger of being evacuated. Id appreciate your prayers for them and their neighbors.. I got ...
Is every child my child? Does ideology end at the bedside of a sick child? I ponder those questions every day when I watch the bravest person I know - my granddaughter. Consider this:
Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently no information on the relation of circulating sclerostin levels to age, gender, or bone mass in humans. Thus we measured serum sclerostin levels in a population-based sample of 362 women [123 premenopausal, 152 postmenopausal not on estrogen treatment (ET), and 87 postmenopausal on ET] and 318 men, aged 21 to 97 years. Sclerostin levels (mean ± SEM) were significantly higher in men than women (33.3 ± 1.0 pmol/L versus 23.7 ± 0.6 pmol/L, p , .001). In pre- and postmenopausal women not on ET combined (n = 275) as well as in men, sclerostin levels were positively associated with age (r = 0.52 and r = 0.64, respectively, p , .001 for both). Over life, serum sclerostin levels increased by 2.4- and 4.6-fold in the women and men, respectively. Moreover, for a given total-body bone mineral content, elderly subjects (age ≥ 60 years) had higher serum sclerostin levels than younger subjects (ages 20 to 39 ...
Several molecular marker systems have been developed for assessing genetic diversity in crop germplasm collections. A trade-off often exists between the number of loci that can feasibly be sampled by a marker system and the amount of information provided by each locus. We compared the usefulness of two marker systems for revealing genetic diversity and population structure in cassava (Manihot esculenta Crantz): simple sequence repeats (SSRs) and diversity array technology (DArT) markers. DArTs survey many more loci per reaction than do SSRs; however, as bi-allelic, dominant markers, DArTs provide less polymorphism information per locus. Genetic differentiation was assessed in a randomly selected set of 436 cassava accessions, consisting of 155 African and 281 Latin American accessions. A genome-wide set of 36 SSR markers and a DArT array of approximately 1000 polymorphic clones were used to assess genetic diversity and differentiation. Cluster analyses were performed using principal coordinate ...
Background Genetic markers and linkage mapping are basic prerequisites for marker-assisted selection and map-based cloning. In the case of the key grassland species Lolium spp., numerous mapping populations have been developed and characterised for various traits. Although some genetic linkage maps of these populations have been aligned with each other using publicly available DNA markers, the number of common markers among genetic maps is still low, limiting the ability to compare candidate gene and QTL locations across germplasm. Results A set of 204 expressed sequence tag (EST)-derived simple sequence repeat (SSR) markers has been assigned to map positions using eight different ryegrass mapping populations. Marker properties of a subset of 64 EST-SSRs were assessed in six to eight individuals of each mapping population and revealed 83% of the markers to be polymorphic in at least one population and an average number of alleles of 4.88. EST-SSR markers polymorphic in multiple populations ...
Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.
To increase the utility of the previously constructed physical map of the chromosome of Neisseria gonorrhoeae FA1090, 28 additional genetic markers were localized on the map. Cloned gonococcal genes were used to probe Southern blots of restriction enzyme-digested DNA separated on pulsed-field gels, thus identifying the fragment in each of several digests to which the probe hybridized and the map location of each gene. The addition of the new markers brings the total number of mapped loci for this strain to 68; the locations of all of those markers on the updated map are shown. ...
A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (single nucleotide polymorphism, SNP), or a long one, like minisatellites. For many years, gene mapping was limited to identifying organisms by traditional phenotype markers. This included genes that encoded easily observable characteristics such as blood types or seed shapes. The insufficient number of these types of characteristics in several organisms limited the mapping efforts that could be done. This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation). Some commonly used types of genetic markers are: RFLP (or Restriction fragment ...
The development of array-based high-throughput genotyping methods created significant opportunities to increase the number of genetic populations for linkage analysis. In the present study, a strategy was proposed for mapping QTLs (quantitative trait loci) based on DArT (diversity arrays technology) genotyping system. A consensus linkage map was constructed with both DArT and SSR markers by utilizing a subgroup DH population, and a second linkage map was constructed with SSR markers alone and a more extensive full DH population. Resistance to barley net-type net blotch disease was analyzed using the subpopulation data with the high-density consensus linkage map and the full-population data with the low-density SSR linkage map, respectively. Two interactive QTLs were detected either by the sub- or full population. Simulation studies were conducted to validate the strategy presented in this chapter. In addition, a computer program written in C++ is freely available on the web to deal with the data ...
Introduction. Genetic linkage maps have been obtained for several plant species and are the basis for advanced genetic studies that provide a better understanding of the inheritance, identification and isolation of genes (Roose et al., 2000). Cloning and gene insertion through genetic transformation have been widely used in species with well-defined genetic maps (Gmitter Jr. et al., 1996).. Different types of molecular markers have been used to obtain genetic linkage maps. Molecular markers are used because they are highly polymorphic and are not influenced by the environment. Among these, random amplified polymorphic DNA (RAPD) markers are the most common because the technique is easy, inexpensive, uses a low amount of genomic DNA, and produces markers that are highly polymorphic and that represent the whole genome (Ferreira and Grattapaglia, 1998). RAPD markers are detected by the random amplification of genomic DNA fragments of different sizes through the polymerase chain reaction (PCR) ...
Simple sequence repeats (SSRs) or microsatellites were tandemly arranged repeats of short DNA motifs (1-6 nucleotides long), which extensively distributed in eukaryotes including the plants, animals and microorganisms, as well as in some prokaryotes [1]. SSRs were commonly regarded as genomic junk with no significant role as genomic information in a long time until the more utilizing of SSR repeat-number variation and accumulating evidence to support the hypothesis that SSRs could play a positive role in adaptive evolution [2-4]. For assaying genetic variation, SSRs markers based on the repeat number variation were showing significant advantages over the variety of other molecular markers, including restriction fragment length polymorphisms (RFLPs), random amplification of polymorphic DNA (RAPD), and amplified fragment length polymorphisms (AFLPs) [5-7]. As a codominant marker, SSRs have proven to be highly polymorphic, easily reproducible, low costing, facility amplified, and not specifically ...
To facilitate mapping of the cystic fibrosis locus (CF) and to isolate the corresponding gene, we have screened a flow-sorted chromosome 7-specific library for additional DNA markers in the 7q31-q32 region. Unique (single-copy) DNA segments were selected from the library and used in hybridization analysis with a panel of somatic cell hybrids containing various portions of human chromosome 7 and patient cell lines with deletion of this chromosome. A total of 258 chromosome 7-specific single-copy DNA segments were identified, and most of them localized to subregions. Fifty three of these corresponded to DNA sequences in the 7q31-q32 region. Family and physical mapping studies showed that two of the DNA markers, D7S122 and D7S340, are in close linkage with CF. The data also showed that D7S122 and D7S340 map between MET and D7S8, the two genetic markers known to be on opposite sides of CF. The study thus reaffirms the general strategy in approaching a disease locus on the basis of chromosome ...
We present a genetic map for Xenopus tropicalis, consisting of 2886 Simple Sequence Length Polymorphism (SSLP) markers. Using a bioinformatics-based strategy, we identified unique SSLPs within the X. tropicalis genome. Scaffolds from X. tropicalis genome assembly 2.0 (JGI) were scanned for Simple Sequence Repeats (SSRs); unique SSRs were then tested for amplification and polymorphisms using DNA from inbred Nigerian and Ivory Coast individuals. Thus identified, the SSLPs were genotyped against a mapping cross panel of DNA samples from 190 F2 individuals. Nearly 4000 SSLPs were genotyped, yielding a 2886-marker genetic map consisting of 10 major linkage groups between 73 and 132cM in length, and 4 smaller linkage groups between 7 and 40cM. The total effective size of the map is 1658cM, and the average intermarker distance for each linkage group ranged from 0.27 to 0.75cM. Fluorescence In Situ Hybridization (FISH) was carried out using probes for genes located on mapped scaffolds to assign linkage ...
The field of molecular phylogenetics has benefited greatly from the recent advances of modern sequencing approaches that allow for the generation of large genomics data sets Nonetheless a lack of suitable genetic markers and incomplete taxon sampling remain common problems in studies of evolutionary relatedness. Most phylogenetic studies are based on mitochondrial DNA (mtDNA) because information about the nuclear genome and strategies to develop new genetic markers are often not available. The use of appropriate genetic markers and the inclusion of both a geographically and phylogenetically comprehensive taxon sampling are required for adequately reconstructing evolutionary histories among different taxa. This is particularly true for studies of recent diversification. Mayflies (Ephemeroptera) are ancient freshwater insects, dating back more than 300 million years, but at the same time have been reported to successfully colonize and diversify on recently formed Atlantic oceanic islands. This combination
A 77-year-old man killed in a crash involving a Plymouth Police Department squad car was on his way to a memorial for his granddaughter, who died by suicide over the weekend, according to loved ones.
Fed up with unreturned calls to the FDA, Frank LaFountain drove himself to Washington, DC on Tuesday in a last-ditch attempt to save the life of his 12-year-old granddaughter, McKenzie Lowe.
Michelle Sears, a 44-year-old Sarasota granny, is accused of bringing along her 6-year-old granddaughter while she did drug deals, according to an arrest affidavit from the Sarasota Couonty Sheriff's Office. A deputy had stopped Sears for driving with a suspended license. When the deputy asked Sears...
Schizophrenia is a complicated disease that often appears in early adulthood. Although scientists have not traced the genetic causes, more than 80% of schizophrenia cases are considered to have a hereditary cause. In a…
After testing several genome complexity reduction methods we identified the PstI/TaqI method as the most effective for Eucalyptus and developed 18 genomic libraries from PstI/TaqI representations of 64 different Eucalyptus species. A total of 23,808 cloned DNA fragments were screened and 13,300 (56%) were found to be polymorphic among 284 individuals. After a redundancy analysis, 6,528 markers were selected for the operational array and these were supplemented with 1,152 additional clones taken from a library made from the E. grandis tree whose genome has been sequenced. Performance validation for diversity studies revealed 4,752 polymorphic markers among 174 individuals. Additionally, 5,013 markers showed segregation when screened using six inter-specific mapping pedigrees, with an average of 2,211 polymorphic markers per pedigree and a minimum of 859 polymorphic markers that were shared between any two pedigrees ...
BEHEREGARAY, L. B., SCHWARTZ, T. S., MÖLLER, L. M., CALL, D., CHAO, N. L. and CACCONE, A. (2004), A set of microsatellite DNA markers for the one-lined pencilfish Nannostomus unifasciatus, an Amazonian flooded forest fish. Molecular Ecology Notes, 4: 333-335. doi: 10.1111/j.1471-8286.2004.00687.x ...
After accounting for the larger physical size of the RGSC 6.0/rn6 rat genome build (2,619 Mb) compared with the original Baylor 3.4/rn4 rate genome build (2,554 Mb), the increased size of the rat genetic map (1,708 cM) is proportional to the original Jensen-Seaman map (1,542 cM). Thus, although the coordinates of highly recombinant regions in the rat genome were refined in the revised rat genetic map, the sex-averaged genomewide recombination rates did not change (0.66 cM/Mb vs. 0.65 cM/Mb). Although the genomewide recombination rates did not change, fine-scale localization of highly recombinant regions differed between the Jensen-Seaman map and the revised rat genetic map. One potential reason for the refined localization of highly recombinant regions in the revised rat genetic map is the greater potential of genetic variation due to the possibility of eight informative HS founder haplotypes per genomic position, whereas prior rat genetic maps relied on crosses between two parental strains with ...
The genetic identification consists to establish the unique and unforgeable DNA fingerprint of a dog, by analysing its DNA.. The DNA fingerprint is made of 22 genetic markers : 21 markers and 1 marker for gender. The genetic markers are coded in letters. The markers combinaison is different from a dog to another , even if they are related ( except true twins).. During parentage verifiation, ANTAGENE compares the DNA fingerprint of the father, the mother and the puppy. The compatible DNA fingerprints betwwen the puppy and the declared parents certify the lineage and brings a DNA certification of the parentage.. The markers panel used by ANTAGENE is following the ISAG 2006 norm.. The ISAG 2006 norm is recognised and validated at the international level by the International Society of Animal Genetics (ISAG). The ISAG 2006 norm is recognised by the FCI (Fédération Cynologique Internationale) and used by almost all Laboratories in Europe.. ANTAGENE is a member of ISAG and scored 100% in the ...
Purpose: BHLHB4 is a transcription factor essential to the maturation of rod bipolar cells (RBs). Adult Bhlhb4-/- mice lack RBs; whilst born in normal numbers, RBs die from postnatal day 8 (PN8) in Bhlhb4-/- retina, suggesting BHLHB4 is required for RB survival. Here we compare the transcriptomes of developing and adult Bhlhb4-/- retina to wildtype (WT) in order to identify novel genetic markers of RBs that may also be important for RB development and/or function.. Methods: Bhlhb4-/- and WT retinal transcriptomes were compared using gene expression microarrays in adult mice (Affymetrix, n=4) and by RNAseq in PN7 mice (n=6): a time that immediately predates significant differences in RB numbers between Bhlhb4-/- and WT retina. Candidate genes were investigated for co-expression with known RB-specific markers in mature RBs using immunofluorescence (IF) and evaluated for differential expression in developing Bhlhb4-/- RBs compared to WT at PN7 with rtPCR and IF.. Results: In adult mice, 97 genes ...
It can be described as some sort of variation present can arise due to mutation or alteration in the genomic loci that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (SNP), or a long one, like microsatellites. Some commonly used types of genetic markers are RFLP, VNTR, Microsatellite Polymorphism, SNP, STR ...
Interpretive Summary: Microsatellite markers form the scaffolding for the construction of the bovine genetic maps and the mapping of genes influencing economically important traits. They have been used to study the divergence, evolution, and domestication of the bovids and genetic differences across and within breeds. Two bloodlines of Romosinuano cattle exist in the U.S.A. today; one from Costa Rica developed by upgrading (COR) and the other, purebred, from Colombia (COL). Because the bloodlines cannot be distinguished by physical appearance, we attempted to find out if genetic markers could be used to: (1) determine the genetic variation between the two bloodlines and (2) whether an individuals bloodline of origin could be determined based on genetic markers. The discernment of bloodline of origin for individual animals has not yet been accomplished in beef cattle. Using 50 public microsatellite markers, we found that allele frequencies among the shared alleles and alleles unique to either ...
Upon returning from the funeral service for his 26-year-old granddaughter, Samantha Louise Thomas, Ucluelet resident Mike Dickie earnestly wants to share this message with his community:. For everybody taking drugs recreationally, be very careful. Not only does it affect the person thats taking them, but its devastating for friends and family.. His granddaughter, who was working and going to school in Vancouver, passed away on Jan. 13, 2018 after overdosing on a fatal pill. A toxicology report would later confirm she had ingested a mixture of cocaine, morphine, and fentanyl.. As far as I know, she was going to a party and somebody gave her a pill. She got into a taxi and died. She was visiting her mom, he said. [Samantha] was so loved. She didnt have an enemy in the world and she never said a bad thing about anybody. Thats all I can say. She was so loved.. Dickie remembers taking his granddaughter fishing in his rowboat and hanging out at local coffee shops when she came to visit the ...
The project aims to develop a novel strategy to improve longevity and maternal traits in a pig breeding program. We will evaluate the use of genetic markers on crossbred animals to strength pig breeding. A method called genomic selection (GS) will be used, which utilizes DNA-markers for the genetic …. Läs mer ...
VANCOUVER, B.C. AND LOS ANGELES - An upcoming feature-length documentary, Mixed Match, explores the unique challenges faced by multiethnic patients with deadly blood diseases when searching for bone marrow donors.. Mixed Match, inspired by the work of L.A.-based outreach group Mixed Marrow, explains how race and ethnicity play a critical role in finding a marrow match for patients suffering from fatal blood diseases.. In order for a marrow or stem cell match to occur between a patient and donor, genetic markers on the cells must align. Because many of these markers are specific to certain ethnic groups, multiracial people often carry markers in uncommon combinations.. To put this in perspective, if a patient diagnosed with leukemia has a mixed Egyptian, Japanese and Russian background, chances are high that only a person with a similar ethnic blend could be a possible donor. For mixed patients, mono-racial parents and relatives will not likely be a genetic match-even siblings hold only a 1 ...
Unique Jan Brouwer Genetic Marker Found: Results from extending the Y-DNA test to 67 markers in some members of the Jan Brouwer descendants has revealed that we have a marker value that is so rare that it is specific to identifying our own family branch within the larger haplogroup I2b1c. A very rare DYS565 Allele value of 7 repeats has been found in the Jan Brouwer descendants. This value defines a unique family branch within the major haplogroup I2b1c; a mutation that likely occurred in an ancestor living in the Belgium / Netherlands / Germany region 400 to 700 years before the present. If two people share the allele value on this marker and are similar enough across the rest of the markers to share a common ancestor in a genealogical time frame, then they belong to the same family branch and everyone without the rare allele does not. - Richard Brewer. ...
TY - JOUR. T1 - DogMap: An international collaboration toward a low-resolution canine genetic marker map. AU - Dolf, G. AU - Batt, R. AU - Baumle, E. AU - Binns, M. AU - Brenig, B. AU - Bull, B. AU - Dunner, S. AU - Fredholm, M. AU - Gaillard, C. AU - Gerlach, J. AU - Giger, U. AU - Goldspink, G. AU - Graphodatsky, AS. AU - Holmes, N. AU - Judd, S. AU - Juneja, K. AU - Kelly, EP. AU - Kent, MG. AU - King, WA. AU - Lingaas, F. AU - Long, SE. AU - Lubas, G. AU - Mariat, D. AU - Marki, U. AU - Matthews, M. AU - Mellersh, C. AU - Mohan, Ram V. AU - Molyneux, K. AU - Morris, B. AU - Niini, T. AU - Panthier, JJ. AU - Pascal, O. AU - Patterson, D. AU - Pihkanen, S. AU - Randi, E. AU - Reimann, N. AU - Rothuizen, J. AU - Sampson, J. AU - Sanchez, A. AU - Sargan, DR. AU - Schelling, C. AU - Schook, LB. AU - Stranzinger, G. AU - Switonski, M. AU - Troyer, D. AU - Van, de Weghe A. AU - Ward OG, null. PY - 1999/1/1. Y1 - 1999/1/1. M3 - Article. VL - 90. SP - 3. EP - 6. JO - Journal of Heredity. JF - Journal ...
Creation of a genetic risk score comprised of multiple genetic markers associated with cardiovascular disease (CVD) was not associated with significant improvement in CVD risk prediction in a study that included more than 19,000 women, according to a study in the Feb. 17 issue of the Journal of the American Medical Association.
The timely characterization and identification of foodborne bacteria for risk assessment purposes is an integral operation in outbreak investigations. recognition of dispersed conserved genomic markers as an excellent control metric to make sure the validity from the analysis. STEC virulence markers had been determined in every isolates examined properly, and solitary colonies were determined within 9 hrs. This technique gets the potential to create high-resolution characterization of STEC isolates, and whole-genome sequence data generated following the GeneSippr analysis could be 53251-94-8 used for isolate identification in place of lengthy biochemical characterization and typing methodologies. Significant advantages of this procedure include ease of adaptation to the detection of any gene marker of interest, as well as to the identification of other foodborne 53251-94-8 pathogens for which genomic markers have been defined. Introduction Traditional techniques for the detection of pathogenic ...
HILDEN, Germany and GERMANTOWN, Maryland, January 10, 2012 /PRNewswire/ -- Licenses diagnostic rights for ALK (anaplastic lymphoma kinase) gene, a promising target for novel class of lung cancer
Genome-wide association studies have identified at least 22 new genetic markers for CHD risk. The current debate around the value of CRP for CHD risk assessment could be considered a warm-up for things to come.
A study carried out by dozens of scientists, and published in Nature Genetics, identified 15 new genetic markers that can increase the risk of breast cancer. Each of these genetic variations, identified through this study and other research, is known to raise a womans risk of breast cancer by a small amount. Its another step towards a better understanding of how genetic variations work to increase the risk of this type of cancer. ...
Molecular phylogenetic is the branch of phylogeny that analyzes hereditary molecular diversity, mainly in DNA sequences, to increase data on an organisms evolutionary relationships. Due to the taxonomic levels of the study, various molecular markers are applied in molecular phylogeny. The selection of molecular instrument is of paramount matter to ensure that a proper level of variation is meliorated to respond the phylogenetic question. In this review, we have been trying to discuss about gene markers used in the plant phylogeny at various taxonomic levels. The current gene markers used in phylogeny include: the ribosomal nuclear genes, low copy nuclear genes and the extra-nuclear genome (mitochondrial and chloroplastic genomes). Conserved regions could be used at higher taxonomic levels in phylogenetics studies and regions with more changes could be applied between closely related taxa. One of the most common sequences for studying the phylogenetic relationships at the generic and infrageneric
Sarah Williams, health information officer at Cancer Research UK, said: This study was carried out in rats, so we cant say whether similar effects could be seen in people. But studies like this can give us hints about whats going on behind the scenes when cancer develops. ...
Well, this is very inneresting!. On Wednesday, a grandmother gave birth to her own granddaughter in Texas! Tracey Thompson welcomed her granddaughter into the world at the Medical Center of Plano, but we promise its not weird!. The story is actually super sweet!. It turns out Traceys daughter, Kelley McKissack, and her husband, Aaron, have been struggling with infertility for quite a while.. Related: Gay Man Wants To Marry His Adopted Son!. After three years of trying to have a baby of their own, three tragic miscarriages, and multiple infertility treatments, the 28-year-olds mother - who had been post-menopause for seven years - offered to carry the child herself.. Doctors gave the 54-year-old a series of treatments that prepared her body for childbearing, and last April she was successfully implanted with one of Kelleys embryos!. Tracey even shared the adorable announcement on Facebook! Ch-ch-check it out (below)! Tags: aaron mckissack, amazing, baby blabber, crazzzzy, family, ...
I have only one more rad treatment left on Monday & I have felt no ill effects of fatigue lately - praise the Lord! Life is Good! My best friends daughter was married last night & it was a beautiful wedding. They are family to us & it was a very heartwarming event. My oldest 2 granddaughters attended the guest book & my next youngest granddaughter was a flower girl. It sure makes you realize how quickly life passes - the bride, her sister (the Maid of Honor) & my 3 girls grew up together taking family trips to the beach, to the lake, & many times celebrating New Years Eve together! It was a blessed event & made me realize how lucky I am to be at the end of chemotherapy & radiation treatments & be able to feel so great & to have had such a wonderful time last night at this sweet wedding!!! No matter what we go through, life is good, & God remains faithful & true ...
Patti, thanks for taking the time to read my tribute to Livie. I have to say even though my heart has been so heavy since the moment we found out about Livies Trisomy 18, God has been there the whole time. God cares about what we care about. Youre right. There will be many that want to see this little miracle who wasnt supposed to make it to the day of her birth, but was instead a gift of joy to us for 14 months, and still is. Thank you for any whispers of prayer you sent up to the Father. He heard them.. ...
Patti, thanks for taking the time to read my tribute to Livie. I have to say even though my heart has been so heavy since the moment we found out about Livies Trisomy 18, God has been there the whole time. God cares about what we care about. Youre right. There will be many that want to see this little miracle who wasnt supposed to make it to the day of her birth, but was instead a gift of joy to us for 14 months, and still is. Thank you for any whispers of prayer you sent up to the Father. He heard them.. ...
Just before the fights began on Saturday night, a grandmother who was about to see her granddaughter get rocked by several hard right hands was at the breaking point. Im so damned nervous! she cried out amid the din of the Red Mouse sports bar in Cross Plains.. As it turned out, she had nothing to worry about. Because boxing is a sport in which even the losers emerge with their honor glinting beneath the bright lights. Her granddaughter lost the fight, but she gained the crowds respect when she refused to go down, and refused to quit, even after a flurry of punches turned her knees to Jell-O.. This was the second annual White Collar Boxing Tournament, a fundraiser for the esteemed Bob Lynch Boxing Foundation. Twenty people entered the ring. Half of them won. Half of them lost. All of them learned what they were made of. They went home proud of their trophies and their various hematomas. ...
Lie a Little Our dorm shared the bathroom with the one next door. We werent exactly friends with our neighbors but we didnt barricade ourselves in our room...well, sometimes we did, especially at night as it would look peculiar if we were found sharing the same bed, regardless of how we could try to explain it. We were in an all-guys dorm, after all. I thought that I could handle being surrounded by a legion of guys of every shape, size and color...and I could...sometimes.
Pascale Mitterrand, 41, filed a complaint with police against Minister Nicolas Hulot. She was outed by French media. Later her lawyer confirmed to MailOnline she was indeed the alleged victim.
The newest reality television show is in some ways like any other: mother and daughters, sibling rivalry, family gossip and talk of Big Grandpa, who
A FIFTY-YEAR-old woman of Mansa has narrated before the local court how her daughters mother in-law went to her house and told her that her daughter was not good enough for her son. This was heard in a case in which Christina Kasanse sued Joyce Kabungo, 60, and Cecilia Chipeta, 16, claiming compensation for insults ...
GENERATIONS fans are sitting on the edges of their seats, sharing the tension faced by the Khumalos as they wait to find out what has happened to their granddaughter Christina. GENERATIONS fans are sitting on the edges of their seats, sharing the tension faced by the Khumalos as they wait to find out what has happened to their granddaughter Christina.
Hi Don, I dfropped in from Scotts Just Used Pixels blog to explore fellow bloggers photo blogs. This was a very original and clever idea. Congrats too on your new little granddaughter. We also have a grandson (5) and a granddaughter (5 mos) and couldnt be more thrilled with them as well.. ReplyDelete ...
Researchers at the University of Southern California (USC) and USC/Norris Comprehensive Cancer Center have identified genetic markers in cancer cells that predicted the benefit of a novel cancer drug prior to chemotherapy.
"New Research Sheds Light on Old Pedigrees". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. ... "Who's Your Momma III: Some Lines Misplaced". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E ... However, modern genetic studies have revealed that there are some cases where the haplotype in the mtDNA of modern ...
"Who's Your Momma II: Some Lines Converge". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. W ... "New Research Sheds Light on Old Pedigrees". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. ... "Who's Your Momma III: Some Lines Misplaced". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E ... One genetic study indicates that 95% of all male Thoroughbreds trace their direct male line (via the Y chromosome) to the ...
Anthropology and genetic markers". Hum. Immunol. 62 (10): 1063. doi:10.1016/S0198-8859(01)00350-0. PMID 11600210. Robin McKie ( ... for having found a marker on Chromosome 7 that is common to Black Africans and, among Caucasoid populations, is found only in ... However they used the same methodology (same gene markers) and same data samples like Arnaiz-Villena et al. Other authors ... They stated that "Using results from the analysis of a single marker, particularly one likely to have undergone selection, for ...
Sources Kole, Chittaranjan (2007). "Molecular Markers and Genetic Mapping". Oilseeds. Volume 2 of Genome Mapping and Molecular ... "Genetic Diversity of Jatropha Curcas With SRAP Molecular Markers". Journal of Zhejiang Forestry College. 27 (3): 347-353. ISSN ... "DNA Polymorphisms Amplified by Arbitrary Primers Are Useful as Genetic Markers". Nucleic Acids Research. 18 (22): 6531-6535. ... "Discriminating Ability of Molecular Markers and Morphological Characterization in the Establishment of Genetic Relationships in ...
"OCD: New Genetic Marker Reported". Retrieved 2015-08-16. Cancer Genome Atlas Network, Koboldt DC, Fulton RS, McLellan MD, ...
Genetic maps, markers and polymorphisms; The C. elegans physical map; Gene expression profiles (stage, tissue and cell) from ... Genetic regulatory relationships; Details of intra- and inter-specific sequence homologies (with links to other Model Organism ...
Bourgeron, T., Giros, B.,(2003). " Genetic Markers in Psychiatric Genetics". In Leboyer, M, Bellivier, F. Psychiatric genetics ... Several genetic risk factors have been found with the endophenotypes of psychiatric disorders, rather than with the diagnoses ... Genetic Linkage studies attempt to find a correlation between the diagnosis and inheritance of certain alleles within families ... In one study, 100% of patients with bipolar disorder indicated that they would probably take a genetic test to determine if he ...
Genetic markers[edit]. Genetic markers are commonly used in Drosophila research, for example within balancer chromosomes or P- ... History of use in genetic analysis[edit]. Alfred Sturtevant's Drosophila melanogaster genetic linkage map: This was the first ... Recessive lethal "balancer chromosomes" carrying visible genetic markers can be used to keep stocks of lethal alleles in a ... Classic genetic mutations[edit]. Drosophila genes are traditionally named after the phenotype they cause when mutated. For ...
"Genetic markers for scoliosis are ID'd". Deseret News. 2008-09-14. Archived from the original on 2009-10-15. Retrieved 2009-10- ... Today, lab workers use special equipment to read each of those 53 genetic markers for all patients who take the ScoliScore test ... Axial Biotech performed a genome-wide association study, testing millions of genetic markers to find any associated with ... "Researchers at Axial Biotech Develop a DNA Test for Scoliosis," PR Newswire, September 11, 2008 "Genetic markers for scoliosis ...
Drewnowski, Adam; Henderson, Susan Ahlstrom; Barratt-Fornell, Anne (2001). "Genetic taste markers and food preferences". Drug ... Subsequent work revealed that the ability to taste PTC was genetic. In the 1960s, Roland Fischer was the first to link the ... Dinehart, M.E.; Hayes, J.E.; Bartoshuk, L.M.; Lanier, S.L.; Duffy, V.B. (2006). "Bitter taste markers explain variability in ... The term originates with experimental psychologist Linda Bartoshuk who has spent much of her career studying genetic variation ...
Mourant, A. E. (1977). "The genetic markers of the blood". In Geoffrey Ainsworth Harrison. Population Structure and Human ... Huang, Cheng-Han; Marion E. Reid; Shen-S- Xie; Olga O. Blumenfeld (1996). "Human red blood cell Wright antigens: a genetic and ... Layrisse, M; Wilbert, J (1961). "Absence of the Diego antigen, a genetic characteristic of early immigrants to South America". ... Eriksson, A. W.; W. Lehmann; N. E. Simpson (1980). "Genetic Studies on circumpolar populations". In Frederick A. Milan. The ...
"Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... "Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... "Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... Although the Thoroughbred is primarily bred for racing, the breed is also used for show jumping and combined training because ...
Palo JU, Ulmanen I, Lukka M, Ellonen P, Sajantila A (April 2009). "Genetic markers and population history: Finland revisited". ... The majority of genetic diseases reported in Finland are not part of the Finnish disease heritage and their prevalence is not ... Genetic governance: Health, risk, and ethics in the biotech era. Routledge. p. 215. ISBN 0-415-35407-2. Levo A, Jääskeläinen J ... Genetic diversity in autosomal chromosomes and in mitochondrial DNA (maternally inherited) is as high among Finns as among ...
"Researchers discover genetic marker linked to OCD". Retrieved November 28, 2016. The Discovery of the Unconscious: The History ... 2014 - The genetic marker associated with the development of obsessive compulsive disorder (OCD) has been identified. ...
... the availability of large-scale genetic markers generated through NGS technology will facilitate trait mapping and make marker- ... European Community, Community Research and Development Information Service (CORDIS) (24 February 2016). "Genetic markers signal ... thereby recognizing crossover events occurring in every progeny line and inserting markers on genetic and physical maps without ... Genetic analysis of wild einkorn wheat suggests that it was first grown in the Karacadag Mountains in southeastern Turkey. ...
Chen KH, Cann H, Chen TC, Van West B, Cavalli-Sforza L (1985). "Genetic markers of an aboriginal Taiwanese population". Am J ... Genetic studies have also found similarities between the Atayal and other people in the Philippines and Thailand, and to a ... However, genetic analysis suggests that the different peoples may have different ancestral source populations originating in ... Rachel A. Chow; Jose L. Caeiro; Shu-Juo Chen; Ralph L. Garcia-Bertrand; Rene J. Herrera (2005). "Genetic characterization of ...
People bearing genetic markers ancestral to Haplogroups C and D came through coastal India and proceeded to Southeast Asia. ... Some northern Chinese have this genetic marker. Another branch, Haplogroups N and O, went south and by 35,000 years ago went on ... This marker alone is carried by all populations in South Asia, Southeast Asia, East Asia, Oceania, and most of the Ameridian ... Genetic evidence indicates that groups of humans began to enter the region 50-60,000 years ago, probably from Africa, settling ...
... genetic characterization by microsatellite markers. Italian Journal of Animal Science 2: 223-230. Documentary on Pentro Horse ... G. Cicia, E. D'Ercole, D. Marino (2003). Costs and benefits of preserving farm animal genetic resources from extinction: CVM ...
... q36.1 and identification of an intragenic genetic marker". Cytogenet. Cell Genet. 73 (1-2): 145-8. doi:10.1159/000134327. PMID ... "Differential splicing of the IA-2 mRNA in pancreas and lymphoid organs as a permissive genetic mechanism for autoimmunity ...
This was demonstrated using highly variable genetic markers. Sperm was also found stored in the spermathecas of queens. Sexual ... However, antibiotic assays and genetic screenings suggest that it is not an endosymbiont such as Wolbachia causing the ... "Cryptic sexual populations account for genetic diversity and ecological success in a widely distributed, asexual fungus-growing ... reproduction was suggested as a mechanism for maintaining the genetic diversity seen in this species. In summary, M. smithii is ...
1967 Genetic markers as tracers in cell culture. Nat Cancer Inst Monogr 26: 167-195 Gartler, SM. 1968 Apparent HeLa cell ... Since the use of genetic markers to characterize and distinguish cell lines at the time was virtually non-existent, ... Cross culture contamination is now a generally accepted risk, and there are many genetic markers available to accurately ... Examining isoenzymes, he typed them for a number of genetic polymorphisms, including the X linked G6PD variant. The cell lines ...
Ikemoto S, Minaguchi K, Suzuki K, Tomita K (1977). "New Genetic marker in human parotid saliva (pm)". Science. 197 (4301): 378- ...
Brett Lee Shelton; J.D. and Jonathan Marks (2008). "Genetic Markers Not a Valid Test of Native Identity". Counsel for ... ScienceDaily (2008). "Genetic Ancestral Testing Cannot Deliver On Its Promise, Study Warns". ScienceDaily. Retrieved 2008-10-02 ... A study reported in The American Journal of Human Genetics stated, "We analyzed the European genetic contribution to 10 ...
Brett Lee Shelton; J.D. and Jonathan Marks (2008). "Genetic Markers Not a Valid Test of Native Identity". Counsel for ... Many researchers have published articles that caution that genetic ancestry DNA testing has limitations and should not be ... http://genetics.ncai.org/tribal-enrollment-and-genetic-testing.cfm ScienceDaily (2008). "Genetic Ancestral Testing Cannot ...
This technology jump-started the modern-day genetic revolution. It is part of Historical Collections of the National Museum of ... He collaborated with J. Claude Bennett researching the genetic coding for protein structure, gene splicing and monoclonal ... the National Institutes of Health as a National Polio Foundation postdoctoral and as a research scientist studying the genetic ...
"Genetic relationship of Porteresia coarctata Tateoka using molecular markers". Plant Biosystems. 136 (3): 339-348. doi:10.1080/ ...
Appel J, Friedman JH (January 2004). "Genetic markers and the majority's right not to know". Mov. Disord. 19 (1): 113-4. doi: ... Presymptomatic diagnosis of MJD can be made with a genetic test. The direct detection of the genetic mutation responsible for ... Genetic testing looks at the number of CAG repeats within the coding region of the MJD/ATXN3 gene on chromosome 14. The test ... The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 ...
Szathmáry (1981). "Genetic markers in Siberian and northern North American populations". Yearbook of Physical Anthropology. 24 ... the problem of first origins and genetic relations". The First Americans: Origins, Affinities, and Adaptations. Szathmáry, ...
Auxotrophic genetic markers are often used in molecular genetics; they were famously used in Beadle and Tatum's Nobel prize- ... Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 775-776: 55-68. doi:10.1016/j.mrgentox.2014.10.005. " ...
"Genetic Correlation between dressage and show jumping ability" (PDF). Dutch Horses Unlimited. Ane Visser. "Genetic Progress for ... In 2010, Dutch Warmbloods were ranked #1 in jumping by the World Breeding Federation for Sport Horses (WBFSH). as well as in ... behind the choice for specialisation is the negative genetic correlation between the ability for dressage and show jumping. By ... WBFSH Jumping statistics, 2010 WBFSH Dressage statistics, 2010 "Search Centre: Results by Competitor". International Federation ...
Jump to navigation Jump to search This article has multiple issues. Please help improve it or discuss these issues on the talk ... Then, they could reliably identify fetal DNA, which would in turn allow them to diagnose certain fetal genetic conditions such ... So they wanted to focus on genetic fragments containing paternally inherited sequences the mother did not share, but had ...
Genetic analysis indicates that there has been an unbroken genetic continuity[clarification needed] of the inhabitants over the ... Jump to navigation Jump to search Major river in Central and Eastern Europe ...
Main article: Genetic causes of type 2 diabetes. Most cases of diabetes involve many genes, with each being a small contributor ... Vitamin D supplementation to people with type 2 diabetes may improve markers of insulin resistance and HbA1c.[119] ... The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors.[25][28] While some of these ... increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants.[13] Most of the ...
Ash fungus genetic code unravelled - BBC News *^ a b c "Chalara dieback of ash (Chalara fraxinea)". Forestry Commission. ... Jump to navigation Jump to search Hymenoscyphus fraxineus Scientific classification Kingdom: Fungi ... A Danish study found that substantial genetic variation between ash trees affected their level of susceptibility.[24] However, ... Gross, A.; Grünig, C. R.; Queloz, V.; Holdenrieder, O. (2012). "A molecular toolkit for population genetic investigations of ...
While schizophrenia is widely believed to be multifactorially genetic by biopsychiatrists, no characteristic genetic markers ... The method makes use of a genetic map of the typed markers, and, like analysis of variance, assumes the presence of a single ... Third, when the markers are widely spaced, the QTL may be quite far from all markers, and so the power for QTL detection will ... The choice of marker covariates has not been solved, however. Not surprisingly, the appropriate markers are those closest to ...
A genetic diversity study of endangered Psiadia species endemic from Mauritius Island using PCR markers». Biochemical ...
Jump to navigation Jump to search Marsh Arabs. Maʻdān معدان. Marsh Arab girl from Al Kurhra, Iraq. ... In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq - - ... Many scholars have proposed historical and genetic links between the Marsh Arabs and the ancient Sumerians based on shared ...
The Gotland rabbit has therefore managed to retain a large genetic diversity in terms of shape and colour, at the same time ... Jump to navigation Jump to search Gotland rabbit. The Gotland rabbit is a Swedish variety of rabbit of medium size that comes ... The Gotland rabbit is considered a hardy variety that is rarely affected by disease or genetic defects.[4] ... maintaining good health and few known genetic illnesses.[2] As show breeds gained popularity, the farm rabbits became rarer ...
"UGT1A1 Genetic Polymorphisms, Endogenous Estrogen Exposure, Soy Food Intake, and Endometrial Cancer Risk". Vanderbilt ...
Genetic information can vary up to 10% between strains.[15] Transformation[edit]. Natural bacterial transformation involves the ... Jump to navigation Jump to search Streptococcus pneumoniae S. pneumoniae in spinal fluid. FA stain (digitally colored). ... S. pneumoniae played a central role in demonstrating that genetic material consists of DNA. In 1928, Frederick Griffith ...
Many genetic principles were discovered or confirmed in this species. It was used by Punnett in early studies of genetic ... Jump to navigation Jump to search Species of flowering plant in the pea and bean family Fabaceae ... It is highly suitable as a genetic subject because of its ability to self-pollinate and its easily observed Mendelian traits ...
CDG syndromes are genetic disorders of the glycosylation pathway. They are labelled "Type I" if the defective gene is for an ... Jump to navigation Jump to search STT3. Structure of yeast OST [1] ...
Jump to navigation Jump to search Organelle. Details. Latin. organella. Identifiers. Code. Padron:TerminologiaHistologica. ...
Jump to navigation Jump to search Paleo-Indians hunting a Glyptodon. Glyptodons were hunted to extinction within two millennia ... Archaeological and genetic data suggest that the source populations of Paleolithic humans survived in sparsely wooded areas and ... According to current archaeological and genetic models, there were at least two notable expansion events subsequent to peopling ...
Jump to navigation Jump to search This article is about a skin disease common during adolescence. For other acneiform skin ... Acne can be a feature of rare genetic disorders such as Apert's syndrome.[15] Severe acne may be associated with XYY syndrome.[ ...
Jump to navigation Jump to search For other uses, see Barnacle (disambiguation). ... Harley, C. D. G.; Pankey, M. S.; Wares, J. P.; Grosberg, R. K.; Wonham, M. J. (December 2006). "Color Polymorphism and Genetic ... To facilitate genetic transfer between isolated individuals, barnacles have extraordinarily long penises⁠. Barnacles probably ...
... he discovered genetic markers that could confirm donor matches. The first physician to perform a successful human bone marrow ... Jump to navigation Jump to search "Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, ... Δ32 homozygous individual with two genetic copies of a rare variant of a cell surface receptor. This genetic trait confers ... In addition, a genetic mismatch as small as a single DNA base pair is significant so perfect matches require knowledge of the ...
In cultured mammalian cells, such as the Chinese hamster ovary cell line, a number of genetic loci are present in a functional ... Jump to navigation Jump to search Homozygous and heterozygous. Zygosity (/zaɪˈɡɒsɪti/) is the degree of similarity of the ... As discussed above, "zygosity" can be used in the context of a specific genetic locus (example[5]). In addition, the word " ... "zygosity" may also be used to describe the genetic similarity or dissimilarity of twins.[6] Identical twins are monozygotic, ...
Fig#1 shows how TipN interact with two other polar proteins : the flagellar marker PodJ , and the stalk marker DivJ. [25] ... The genetic network logic responds to signals received from the environment and from internal cell status sensors to adapt the ... The genetic basis of the phenotypic differences between the two strains results from coding, regulatory, and insertion/deletion ... The central feature of the cell cycle regulation is a cyclical genetic circuit-a cell cycle engine-that is centered around the ...
Jump to navigation Jump to search Transmission electron micrograph of a mesenchymal stem cell displaying typical ... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the ...
Jump to navigation Jump to search The science and practice of the diagnosis, treatment, and prevention of disease ... as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in ... transcription and translation of the genetic material. ...
Agrobacterium-mediated genetic engineering techniques were developed in the late 1980s that could successfully transfer genetic ... Jump to: navigation, search Plant physiologist Athanasios Theologis with tomatoes that contain the bioengineered ACC synthase ... A genetically modified tomato, or transgenic tomato, is a tomato that has had its genes modified, using genetic engineering. ... Tomato as a model system: I. Genetic and physical mapping of jointless". MGG Molecular & General Genetics. 242 (6). doi:10.1007 ...
Genetic skeletal dysplasias also known as osteochondrodysplasia usually manifest in short-limbed disproportionate short stature ... Jump to navigation Jump to search Short stature. Specialty. Endocrinology Short stature refers to a height of a human being ... The deficiency may be genetic. Among children without growth hormone deficiency, short stature may be caused by Turner syndrome ... On the other hand, most genetic skeletal dysplasias are known for short stature that may be proportionate or disproportionate. ...
Jump to: navigation, search Interactive Specialization is a theory of brain development proposed by the British cognitive ... Development is not a simple question of a brain being built according to a pre-specified genetic blueprint - rather, the ...
Jump to navigation Jump to search The tendency for maximum complexity to increase over time, though without any overall ...
... genetic factors; immunodeficiencies; loss of habitat; changing beekeeping practices; or a combination of factors.[218][219] ... Marker, Laurie; Marnewick, Kelly; Melzheimera, Joerg; Merkle, Johnathan; M'sokab, Jassiel; Msuhac, Maurus; O'Neill, Helen; ...
Jump to navigation Jump to search This article is about the species Lens culinaris. For the meaning of "lentil" in Indian ... Wild Lens species are a significant source of genetic variation for improving the relatively narrow genetic base of this crop. ... Serious genetic improvement for yield has been made, however, the full potential of production and productivity could not yet ... Although lentils have been an important crop for centuries, lentil breeding and genetic research has a relatively short history ...
Jump to: navigation, search This article is about androgens as natural hormones. For androgens as medications, see Anabolic ... a genetic disorder resulting in complete or partial insensitivity to androgens and a lack of external male genitalia. ...
... as revealed by genetic markers". Royal Society Publishing. 2: 150450. doi:10.1098/rsos.150450. PMC 4807452. PMID 27019731.. ... Genetic considerationsEdit. The wolf-like canids are a group of large carnivores that are genetically closely related because ... Documenting Domestication:New Genetic and Archaeological Paradigms. University of California Press. pp. 279-295. ISBN ... However, recent genetic and morphological evidence suggests that the red wolf is a unique taxon. Wilson et al. (2000) report ...
This compares with 25% of Cw7-B7 that extend to A3::DQ6 [4] Of 25 potential genetic recombinants of A1::DQ2, none exceed 10% of ... Jump to navigation Jump to search Multi-gene haplotype, human HLA region on chromosome 6 ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ... February 1999). "The genetic basis for the association of the 8.1 ancestral haplotype (A1, B8, DR3) with multiple ...
He and his colleagues asked whether any genetic markers could indicate the extent of aging in different tissues and among ... Researchers have long searched for molecular markers that track the rate of physical deterioration that accumulates with age. ... Such work has led to a mishmash of markers that have little in common, notes Zahn. ...
These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker ... The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. In phase l, the plan isto ... This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large ... will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic ...
An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific ... An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific ... International study identifies genetic markers for cancer. Study holds tremendous implications for early detection and ...
University of Chicago researchers said they have identified a genetic marker that will help identify children who are most ... One of the most important findings in the study is that now we have a genetic marker that helps us identify those children with ... Those children who had two copies of the genetic marker were almost four times as likely to develop asthma as children who did ... The researchers found that 90 percent of children under age 3 who wheezed after catching a cold and had the genetic marker, ...
The HCP5 genetic marker was not a good predictor of quitting abacavir, perhaps because the study considered stopping abacavir ... Respective rates for men were 50% and 24.3%. The SHCS investigators noted that certain genetic markers they analyzed are more ... For the other four drugs, hazard ratios adjusted for other risk factors found that genetic markers independently predicted ... Among women, 80% of those with a risk marker versus 42.5% of those without a risk marker stopped efavirenz. ...
Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg ... CitacióGraffelman, J. Exploring Diallelic genetic markers: The Hardy Weinberg package. "Journal of statistical software", Març ... Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets ... log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. ...
... Bjartell, Anders LU (2011) In European Urology 60. p.29-31 *Mark ... Genetic Markers and the Risk of Developing Prostate Cancer.}, url = {http://dx.doi.org/10.1016/j.eururo.2011.03.005}, volume ...
Breeding technique allows farmers to conventionally breed plants based on genetic markers; GMOs are unnecessary, costly, ... In contrast, MAS uses biotechnology only to identify genetic markers linked to traits that farmers find desirable, such as pest ... Breeding technique allows farmers to conventionally breed plants based on genetic markers; GMOs are unnecessary, costly, ... Breeding technique allows farmers to conventionally breed plants based on genetic markers; GMOs are unnecessary, costly, ...
Many of the newly recognized clinically significant genetic markers in pediatric leukemias cannot be reliably detected by ... Utilization of Optical Genome Mapping in Detection and Characterization of Rare Genetic Markers in Pediatric Leukemias. ... Many of the newly recognized clinically significant genetic markers in pediatric leukemias cannot be reliably detected by ... Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic ...
Guihua Bai turns the spotlight on to the wonderful world of wheat and DNA markers ... and tightly linked markers to these genes for their application in marker-assisted breeding; (2) Develop innovative DNA marker ... which significantly increases marker analysis efficiency and reduces the cost of marker assay for marker-assisted breeding. ... Home Open Access News Environment News DNA markers for wheat genetic improvement ...
There are many genetic markers on each chromosome. Genetic markers and genes that are close to each other on a chromosome are ... genetic marker (jeh-NEH-tik MAR-ker) listen A specific sequence of DNA at a known location on a chromosome. ... This may help researchers find a gene near a marker that may cause a certain disease or trait within a family. Examples of ...
RAD markers (or Restriction site associated DNA markers). Molecular genetic markers can be divided into two classes a) ... Genetic markers are employed in genealogical DNA testing for genetic genealogy to determine genetic distance between ... Jump to navigation Jump to search Chicks atop a picture of a genetic map of a chicken. The chicken genome has 39 pairs of ... Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a ...
Genetic markers are thus estimators of biological relatedness, and when they are shared by individuals they are interpreted as ... Genetic MarkerA genetic marker is a trait transmitted from parent to child, thus potentially permitting the reconstruction of ... Genetic Marker Encyclopedia of Race and Racism COPYRIGHT 2008 Thomson Gale. Genetic Marker. A genetic marker is a trait ... A common genetic marker is less valuable than a rare one, for the simple reason that a match between two samples is more likely ...
Scientists have identified early genetic markers that can potentially predict who is at an increased risk for developing ... Genetic markers found to predict Alzheimers Published April 05, 2013. Fox News ... Scientists have identified early genetic markers that can potentially predict who is at an increased risk for developing ... After performing a genetic analysis on 1,269 patients, Goate and her team identified genetic mutations in a previously ...
Delles C., Dominiczak A.F. (2010) Redox-Related Genetic Markers of Cardiovascular Diseases. In: Sauer H., Shah A., Laurindo F ... Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 360(4):363-375PubMedCrossRefGoogle ... Rapp JP (2000) Genetic analysis of inherited hypertension in the rat. Physiol Ver 80:135-172Google Scholar ... Tang NP, Wang LS, Yang L, Gu HJ, Sun QM, Cong RH, Zhou B, Zhu HJ, Wang B (2008) Genetic variant in glutathione peroxidase 1 ...
DNA analysis of thousands of people with and without pancreatic cancer finds five new genetic risk markers that could be used ... Prostate cancer: Scientists find 63 new genetic markers Research locates new genetic markers that may show an elevated risk ... New study brings to nine the number of genetic markers for pancreatic cancer. This new study, PanScan III, brings to nine the ... "Pancreatic cancer study finds new genetic risk markers." Medical News Today. MediLexicon, Intl., 4 Aug. 2014. Web.. 22 Apr. ...
... has identified specific genetic markers for scoliosis. And its using the knowledge in a DNA-based prognostic test for spinal ... A Salt Lake company, Axial Biotech Inc., has identified specific genetic markers for scoliosis. And its using the knowledge in ... Scoliosis is a genetic disease that occurs when the spine twists and curves sideways. Adolescent idiopathic scoliosis is that ... Researchers at the company are also analyzing data they hope will lead to better understanding of genetic factors that cause ...
Genaissance Pharmaceuticals has identified some genetic markers in people that indicate they will benefit most from cholesterol ... said it has identified some genetic markers in people that indicate they will benefit most from cholesterol-lowering drugs. ...
... is considered as one of the major tools in genetic improvement of crop plants in this genomics era. This book describes basics ... Genetic mapping and marker assisted selection (MAS) is considered as one of the major tools in genetic improvement of crop ... Genetic diversity Linkage mapping Marker assisted selection Molecular breeding QTL mapping Authors and affiliations. *N. ... To summarize, this book describes technologies for identification of genes of interest through genetic mapping, recaps the ...
In addition to confirming the eight genetic variants that had already been linked to longevity, this study found 17 more to ... Number of genetic markers linked to lifespan triples An international study found 25 genetic variants linked to human longevity ... number-genetic-markers-linked-lifespan-triples/. More in Medicine & Health. * Featured research from NUTRITION 2020 LIVE ONLINE ... Number of genetic markers linked to lifespan triples. University of Connecticut. Journal. Aging. Funder. Medical Research ...
Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. This is the ... largest set of markers of lifespan uncovered to date. ... This is the largest set of lifespan-associated genetic markers ... Researchers uncover 16 genetic markers linked to decreased lifespan. *Download PDF Copy ... Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. This is the ...
Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer. Previously ... characterized mutations in markers at 8q24 are associated with a broader population than previously reported and with much more ... Genetic Marker For Aggressive Prostate Cancer 36 Posted by kdawson on Monday May 21, 2007 @01:28AM. from the like-a-racehorse ... "Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer. Previously ...
Genetic markers cannot determine Jewish descent. Raphael Falk*. *Department of Genetics, Program for History and Philosophy of ... 4. ^Haplotype, a contraction of the phrase "haploid genotype," is a set of closely linked genetic markers, a combination of DNA ... Citation: Falk R (2015) Genetic markers cannot determine Jewish descent. Front. Genet. 5:462. doi: 10.3389/fgene.2014.00462 ... Still, the tradition of following discrete genetic markers on the one hand, and the development of methods for following a ...
New research suggests that a simple genetic test could be used to identify multiple sclerosis patients at risk of developing ... Scientists discover genetic markers for severe form of multiple sclerosis Findings may open door to precision medicine for ... The genetic markers for high MIF expression are especially prevalent among men, who disproportionately suffer from the more ... Scientists discover genetic markers for severe form of multiple sclerosis. Oregon Health & Science University ...
Predicting genetic predisposition in humans: the promise of whole-genome markers.. de los Campos G1, Gianola D, Allison DB. ... A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in ... Although genome-wide association studies have identified markers that are associated with various human traits and diseases, ...
Genetic relationships of five Indian horse breeds using microsatellite markers - Volume 1 Issue 4 - R. Behl, J. Behl, N. Gupta ... Genetic relationships of five Indian horse breeds using microsatellite markers. * R. Behl (a1), J. Behl (a1), N. Gupta (a1) and ... Horse genetic resources of India: Spiti ponies. NBAGR Publication, National Bureau of Animal Genetic Resources, Karnal, India. ... Genetic data analysis. Sinauer, Sunderland, MA, USA.. Weir, BS and Cockerham, CC 1984. Estimating F-statistics for the analysis ...
... Rosmeri K. Lazzaretti,1 Aline S. Gasparotto,2 ... M.-H. Chang, A. Yesupriya, R. M. Ned, P. W. Mueller, and N. F. Dowling, "Genetic variants associated with fasting blood lipids ... A. Kay, W. März, M. M. Hoffmann et al., "Coronary artery disease and dyslipidemia within Europe: genetic variants in lipid ... ancestry-informative marker (AIM) panel," Human Mutation, vol. 31, no. 2, pp. 184-190, 2010. View at Publisher · View at Google ...
Study On Rabbit Brain Reveals Genetic Markers Of Domestication. January 17, 2021. Texas A&M ... researchers are able to better understand the link between genetic changes and the mechanisms of evolution in rabbits and, at a ...
Genetic Markers for Focal Segmental Glomerulosclerosis. The safety and scientific validity of this study is the responsibility ... We will draw blood for genetic testing. Our purpose is to determine whether particular genetic variants, including those in ... Currently, over thirteen genetic mutations are associated with FSGS. We are interested in expanding our understanding of these ... Genetic and Rare Diseases Information Center resources: Focal Segmental Glomerulosclerosis Glomerulonephritis U.S. FDA ...
... Rosmeri K. Lazzaretti,1 Aline S. Gasparotto,2 ...
Genetic traceability of black pig meats using microsatellite markers.. Oh JD1, Song KD1, Seo JH1, Kim DK1, Kim SH1, Seo KS2, ... In total 800 Jeju black pigs and 351 Berkshires were genotyped at thirteen microsatellite (MS) markers. Analyses on the genetic ... In addition, genetic structure analysis revealed the possibility of gene flow from population B to population J. The expected ... To examine the feasibility of such a system, we aim to provide basic genetic information of the two black pig populations and ...
Shares of the clinical-stage biopharma Applied Genetic Technologies Corporation rose by 23% today on a huge surge in volume ... Why Applied Genetic Technologies Corporation Stock Jumped Today. By George Budwell. Published July 02, 2015. Fool.com ... The article Why Applied Genetic Technologies Corporation Stock Jumped Today originally appeared on Fool.com. ... 30 million investment in Applied Genetic shares. If any products make it to the commercial stage, Applied Genetic would also be ...
Consortium to Identify Genetic Markers that Predict Drug-related Serious Adverse Events. September 27, 2007 , by Walter Jessen ... the U.S. Food and Drug Administration (FDA), and academic institutions plans to identify and validate genetic markers that may ... Genetic Test Results Do Not Trigger Increased Use of Health Services. May 21, 2012 , by NIH Newsbot ... People have increasing opportunities to participate in genetic testing that can indicate their range of risk for developing a ...
In total 80 alleles were detected among 28 genotypes with an average of four alleles per locus and an average marker diversity ... Th e objective of this study was to assess genetic diversity and relationships of 23 soybean genotypes representing several ... use of these genotypes in making crosses to develop further breeding cycles can result in an insuffi cient level of genetic ... breeding sources from Southeastern Europe and fi ve plant introductions from Western Europe and Canada using 20 SSR markers. ...
Assessment of genetic diversity in 35Pisum sativumaccessions using microsatellite markers. Can. J. Plant Sci. 92: 1075-1081. ... Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers. ... "Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers," Canadian Journal of Plant Science ... "Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers," Canadian Journal of Plant Science ...
Identification of SSR markers for hybridity and seed genetic purity testing in sunflower (Helianthus annuus L.) ... In order to identify pure hybrids and pollen shedders/offtypes an investigation was done to identify an ideal SSR marker. 58 ... primer pairs were screened to identify specific markers associated with each hybrid and parental lines. Hybrid KBSH-44 could be ...
Demonstrating gains or losses of DNA segments ,1 kb, CNVs are the most common type of variations in genetic structure. More ... Germline CN variants (CNVs) have emerged as key determinants in genetic predisposition to breast cancer and other diseases. ... Based largely on single nucleotide polymorphisms (SNPs) in genes, genetic pathways, or whole-genome scans, studies have ...
A new study suggests that a genetic allele commonly associated with Alzheimers also conveys an increased risk of late-life ... An allele is a form of a gene that can be used to predict the genetic likelihood of someones susceptibility -- and APOE ε4 is ... APOE ε4 might be a marker for identifying older persons at risk to develop depression or dementia, which could be important for ...
  • DNA marker is an emerging technology that can speed up breeding process and improve selection accuracy by breeding selection to stack multiple genes/traits simultaneously by selecting DNA markers that selecting either tightly linked markers to the target genes or part of gene sequences. (openaccessgovernment.org)
  • DNA isolated from a small piece of leaf tissue is enough for evaluation of hundreds of genes/markers. (openaccessgovernment.org)
  • Using new genomics and marker technologies, our Genotyping Lab identified new genes or quantitative trait loci (QTLs) controlling many important wheat traits including wheat resistance to aluminium toxicity, stem rust, leaf rust, soilborne mosaic virus, Fusarium head blight, tan spot and preharvest sprouting and yield and quality-related traits. (openaccessgovernment.org)
  • Breeder-friendly markers were developed for most of these genes/QTLs and have been used in routine breeding practice, to help breeders to select for the target genes in their breeding materials. (openaccessgovernment.org)
  • Our lab cloned two important wheat genes for resistance to pre-harvest sprouting and Fusarium head blight and developed diagnostic markers for these genes. (openaccessgovernment.org)
  • To improve a throughput of marker analysis and use next-generation sequencing technologies in breeding, our lab developed a new technology called genotyping by multiplexing amplicon sequencing (GBMAS) for high-throughput assays of wheat target genes. (openaccessgovernment.org)
  • Genetic markers and genes that are close to each other on a chromosome are usually inherited (passed from parent to child) together. (cancer.gov)
  • There are many genetic markers on each chromosome. (cancer.gov)
  • The Double marker check helps to find out this situation by checking for markers that are altered if a fetus with this further chromosome is current. (dbdigitech.com)
  • These markers will also be used to detect different trisomies, particularly, Edward syndrome (trisomy of chromosome 18) and Patau syndrome (trisomy of chromosome 13). (dbdigitech.com)
  • Examples of genetic markers are single polymorphism nucleotides (SNPs) and microsatellites. (cancer.gov)
  • Recent advances in high-throughput genotyping have made it easier to combine information from different mapping populations into consensus genetic maps, which provide increased marker density and genome coverage compared to individual maps. (cas.cz)
  • Researchers have long searched for molecular markers that track the rate of physical deterioration that accumulates with age. (sciencenews.org)
  • This may help researchers find a gene near a marker that may cause a certain disease or trait within a family. (cancer.gov)
  • In contrast, MAS uses biotechnology only to identify genetic markers linked to traits that farmers find desirable, such as pest or drought resistance. (naturalnews.com)
  • Conventional plant breeding is highly effective at producing complex, multi-genetic traits -- unlike genetic engineering, which can only modify traits produced by a single gene at a time. (naturalnews.com)
  • Abstract Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. (sbir.gov)
  • Armed with this more specific information about a plant's genetics, farmers are able to use conventional breeding techniques to produce new strains much more rapidly -- and much more quickly and effectively than can be delivered by genetic engineering. (naturalnews.com)
  • As mentioned elsewhere in this document, in the clinical research process and assistance it will be essential the use of genetic biomarkers, this will allow to generate drugs for groups of patients (stratification) or in some cases individualization. (proyectomedea.es)
  • The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. (sbir.gov)
  • In phase l, the plan isto describe a method to identify large-numbers of the new markers and to isolate and characterizeseveral examples. (sbir.gov)
  • These Genotyping Labs provide free marker service to the breeders in each region, therefore, all the wheat breeding programmes have access to newly developed marker technologies and use them in their routine breeding. (openaccessgovernment.org)
  • These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. (sbir.gov)
  • To successfully use DNA markers in routine breeding, however, a breeding programme needs to have specialised equipment and well-trained personnel for DNA marker analysis, which is often unaffordable for many small breeding programmes. (openaccessgovernment.org)
  • Indeed, the conventional breeding technique known as marker-assisted selection (MAS) allows farmers to rapidly develop new strains of important crops, without the high costs or dangers of genetic engineering. (naturalnews.com)
  • Date: October 29, 2020 Time: 6:00am (PDT), 9:00am (EDT), Chronic inflammation can occur as a result of a combination of genetic predispositions and environmental factors. (labroots.com)
  • Among the genetic markers, those that determine the metabolic capacity are the most studied and those most included in the regulation framework. (proyectomedea.es)
  • The genetic relationships of five Indian horse breeds, namely Marwari, Spiti, Bhutia, Manipuri and Zanskari were studied using microsatellite markers. (cambridge.org)
  • Genetic traceability of black pig meats using microsatellite markers. (nih.gov)
  • Regions of DNA variation are commonly used for identification purposes, such as in human paternity tests and genetic fingerprinting, but these methods have traditionally relied on larger areas of polymorphism in the DNA sequence known as microsatellite markers. (thepoultrysite.com)
  • In gene-mapping studies, DNA markers are commonly differences of a single base among individuals in a population (such differences are called single nucleotide polymorphisms, or SNPs). (encyclopedia.com)
  • The markers are single-nucleotide polymorphisms (SNPs or 'snips'), where a single letter variation occurs in a sequence of DNA in the genome. (medicalnewstoday.com)
  • The SNP array, a technology used to examine hundreds of thousands of features within DNA, detects single nucleotide polymorphisms and establishes genetic markers that can be used to understand the entire genome, particularly with respect to disease susceptibility and the likely success of insecticides and other mosquito-targeted interventions. (scienceblog.com)
  • Professor Armand Sánchez and his colleagues from the Department of Animal and Food Sciences, Universitat Autònoma de Barcelona, and scientists from Applied Biosystems have developed a panel of 46 genetic markers that are all single nucleotide polymorphisms (SNPs), which are single sites of variation in the animal's DNA sequence. (thepoultrysite.com)
  • Although CRC is a disease that is largely influenced by lifestyle and dietary factors ( 4 ), recent studies have suggested that interindividual genetic variations such as single-nucleotide polymorphisms (SNP) may affect risk for CRC ( 5-7 ). (aacrjournals.org)
  • This chapter describes which gene polymorphisms and serological markers may be used to distinguish between ulcerative colitis and Crohn's disease in patients with histologically unclassified colitis. (edu.mt)
  • However, investigation of genetic causes of idiosyncratic drug reactions has the potential to be more worthwhile than the investigation of effects like myopathy with statins in terms of the predictive value of the polymorphisms. (mja.com.au)
  • Haplotypes of IL-4 receptor and CD14 genetic polymorphisms are markers of susceptibility for diisocyanate asthma. (cdc.gov)
  • The study authors analyzed genetic and clinical data from 1,087 malignant glioma patients and 11,590 healthy controls from Mayo Clinic, UCSF and The Cancer Genome Atlas, a program of the National Cancer Institute. (eurekalert.org)
  • Predicting genetic predisposition in humans: the promise of whole-genome markers. (nih.gov)
  • Together, the two studies, for which Genome Canada, Génome Québec and the Canadian Institutes of Health Research are among the principle funders, involved analyzing the genetic data of about 275,000 women, including 146,000 who had been diagnosed with breast cancer. (theglobeandmail.com)
  • Each marker is like a genetic signpost along the genome. (scienceblog.com)
  • By using correlations among genetic markers close to one another in the genome, the method can succeed even if the datasets contain no overlapping markers. (pnas.org)
  • Thus, for example, genome-wide association study samples typed with different SNP sets are routinely combined by cross-imputation, in which markers typed only in a subset of samples are probabilistically imputed in each sample, so that all markers can be analyzed in all samples ( 1 ⇓ - 3 ). (pnas.org)
  • In a genetic context, record matching involves the identification of the same individual genome across multiple datasets when unique identifiers, such as participant names, are unavailable. (pnas.org)
  • The completion of the Human Genome Project in 2003 and the development of cost-effective means for scanning large regions of DNA have paved the way for large-scale pharmacogenetic investigations involving many genetic loci. (mja.com.au)
  • A genome of 1000 cM was simulated with a marker spacing of 1 cM. (genetics.org)
  • The study used a genome-wide association design in which the frequencies of hundreds of thousands of genetic variations across the genome are compared between large numbers of cases and unaffected controls. (innovations-report.com)
  • In the first stage, more than 620,000 genetic variations were analyzed in the whole genome of 1,817 women with ovarian cancer and compared to 2,353 women without the disease. (innovations-report.com)
  • The study used a methodology called genome-wide association mapping, which looks at genetic variations across the entire genome that alter the individual building blocks of DNA makeup. (mskcc.org)
  • The four markers made available by Iowa State University precede the current effort to sequence the swine genome, but they are an indication of how this research can be applicable on the farm. (thepigsite.com)
  • Now, by comparing the complete genomes of 297 parasites isolated from Cambodian malaria patients to a reference malaria parasite genome, the team has identified two genetic markers that are strongly associated with the parasites' ability to resist piperaquine. (nih.gov)
  • More than 1800 individuals sampled from 105 sites were analyzed with a set of allozyme loci (hopefully representing neutral or nearly neutral markers) and X-linked loci (which are assumed to be under selection). (bioone.org)
  • We show that records can be matched across genotype datasets that have no shared markers based on linkage disequilibrium between loci appearing in different datasets. (pnas.org)
  • A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species . (wikipedia.org)
  • For many years, gene mapping was limited to identifying organisms by traditional phenotype markers. (wikipedia.org)
  • This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation). (wikipedia.org)
  • Molecular genetic markers can be divided into two classes a) biochemical markers which detect variation at the gene product level such as changes in proteins and amino acids and b) molecular markers which detect variation at the DNA level such as nucleotide changes: deletion, duplication, inversion and/or insertion. (wikipedia.org)
  • Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a particular mutation of a gene that results in a defective protein ). (wikipedia.org)
  • This property enables the use of a marker, which can then be used to determine the precise inheritance pattern of the gene that has not yet been exactly localized. (wikipedia.org)
  • The results confirm that many genetic variants combine to influence human lifespan: no single gene variant has been found to be responsible. (eurekalert.org)
  • Shares of the clinical-stage biopharma Applied Genetic Technologies Corporation rose by 23% today on a huge surge in volume after the company inked a broad research collaboration with biotech giant Biogen to develop multiple gene therapy treatments for rare diseases of the eye. (foxbusiness.com)
  • Regarding Applied Genetic, this tiny biopharma could receive milestone payments in excess of $1 billion, if its gene therapy platform bears fruit. (foxbusiness.com)
  • An allele is a form of a gene that can be used to predict the genetic likelihood of someone's susceptibility -- and APOE ε4 is particularly associated with dementia. (wired.co.uk)
  • The abacavir hypersensitivity marker they focused on was not HLA-B*5701 [2], but the HCP5 gene shift designated rs2395029. (natap.org)
  • It could be concluded that markers that are targeted to specific gene sequences may still behave as anonymous markers if their relationship with the phenotypic variation has not been established. (wur.nl)
  • Li, G. and Quiros, C.F. (2001) Sequence-Related Amplified Polymorphism (SRAP), a New Marker System Based on a Simple PCR Reaction: Its Application to Mapping and Gene Tagging in Brassica. (scirp.org)
  • The new marker was found on chromosome 9, close to the BNC2 (basonuclin 2) gene that encodes a protein which plays a role in regulation of DNA transcription and is highly expressed in reproductive tissues. (innovations-report.com)
  • The first gene marker is MC4R and it controls growth and leanness. (thepigsite.com)
  • The second gene marker is PRKAG3. (thepigsite.com)
  • The third gene marker is CAST, a gene that affects tenderness and meat quality. (thepigsite.com)
  • The fourth gene marker is HMGA1, which is highly associated with backfat and lean growth. (thepigsite.com)
  • The first marker they identified is a change of one subunit in a gene on the parasite's chromosome 13. (nih.gov)
  • Working on something like SCCOHT seemed an obvious choice as it is a unique genetic disease driven by loss of a single gene, SMARCA4 ," explains Dr. Huang, who is also a member of McGill's Goodman Cancer Research Centre. (mcgill.ca)
  • Dr. Jerome F. Strauss III, dean of the Virginia Commonwealth University's School of Medicine, found that African American babies are three times more likely than babies of European descent to have genetic variation of the SERPINH1 gene which results to the production of less collagen, and therefore weakened fetal membranes which contributes to an increased chance of premature rupture of the membranes and premature birth. (biotech-weblog.com)
  • Dr. Xiaobin Wang, from the Children's Memorial Hospital in Chicago, Illinois, on the other hand, discovered that a genetic variant of the prolylcarboxypeptidase gene is linked to incidence of preeclampsia, a condition that can develop around the 20th week of gestation, characterized by high blood pressure and high levels of protein in the urine. (biotech-weblog.com)
  • Especially for the latter, a genetic marker reflects a DNA sequence which is linked to a gene or trait of interest, and can thereby be directly used in marker-assisted selection (MAS). (ait.ac.at)
  • And each group had a separate genetic signature based on variations in the way they expressed the LIN28 and OLIG2 genetic markers. (fiercebiotech.com)
  • They found that each group had its own genetic signature through subtle differences in the way they expressed two genetic markers, LIN28 and OLIG2. (healthcanal.com)
  • Ultimately, the research has identified the two genetic markers LIN28 and OLIG2 as a promising basis for more effective tools for diagnosing and predicting outcomes for young patients with these types of brain tumours. (healthcanal.com)
  • Genetic markers have to be easily identifiable, associated with a specific locus , and highly polymorphic , because homozygotes do not provide any information. (wikipedia.org)
  • This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large number of the markers, more thorough characteriza-tion of their polymorphic content, and application in generation of linkage maps. (sbir.gov)
  • These markers were scored by their polymorphic information content (PIC), ranging from 0.055 (AA206) to 0.660 (AB72) with an average of 0.460, and by their discriminating power (D), which varied from 0.057 (AA206) to 0.679 (AB 72) with an average of 0.475. (bioone.org)
  • DNA markers linked to insensitivity were obtained by bulked segregant analysis using random amplified polymorphic DNA (RAPD) markers and the Dutch and Mexican crosses. (apsnet.org)
  • Consequently, use of these genotypes in making crosses to develop further breeding cycles can result in an insuffi cient level of genetic variability. (psu.edu)
  • The work of Dr. Eng and her colleagues indicates that genetic alterations within breast cancer tumors are likely the prime reason for the variability among patients. (emaxhealth.com)
  • Wild species are important sources of genetic variability and may be exploited by breeding programs. (scielo.br)
  • This agreement is obviously a much bigger deal for Applied Genetic than Biogen, but it does signal that Biogen is deeply interested in diversifying its clinical pipeline. (foxbusiness.com)
  • The two companies agreed to a rather fluid deal that allows Applied Genetic to opt-in in terms of sharing development costs and profits after the initial clinical data are a known entity. (foxbusiness.com)
  • Applied Genetic will also be responsible for shepherding these experimental products through the clinical trial process, with Biogen playing a supportive role during this process. (foxbusiness.com)
  • This newly identified genetic marker will not have any immediate clinical implications or impact on current screening guidelines for familial breast cancer," said Dr. Offit. (mskcc.org)
  • Although the predictive accuracy of the genetic-only model (positive likelihood ratio of 2.0) was comparable with that of the clinical-only model (positive likelihood ratio of 2.1), the combination of the two models generated a statistically significant increase in predictive power (positive likelihood ratio of 3.4). (sciencemag.org)
  • Soon, we may be able to better care for patients by using a risk-adapted strategy based on a combination model of clinical, radiographic, laboratory, and genetic risk factors. (sciencemag.org)
  • Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis. (sciencemag.org)
  • 10 This was the first time a regulatory authority had recognised a genetic predisposition for a hypersensitivity reaction. (mja.com.au)
  • If the data are confirmed, the marker may help clinicians personalize prostate cancer screening. (biologynews.net)
  • Genetic testing for prostate cancer is not yet clinically well characterized as it is for breast, ovarian cancer and colon cancer," Giri says. (biologynews.net)
  • They then evaluated this marker in 183 Caucasian men who have a family history of prostate cancer undergoing follow-up in the Prostate Cancer Risk Assessment Program. (biologynews.net)
  • Genetic testing for HOXB13-CIP2A could help identify these patients sooner and may bring new opportunities for the early detection and precision oncology in prostate cancer. (utu.fi)
  • Genetic Markers and the Risk of Developing Prostate Cancer. (lu.se)
  • Serological and biochemical genetic markers in congenital cleft lip and cleft palate anomalies. (biomedsearch.com)
  • Serological and biochemical genetic markers in 76 patients with cleft lip with or without cleft palate [CL(P)] and 24 patients with isolated cleft palate (CP) were studied and compared with healthy control subjects. (biomedsearch.com)
  • Analysis of the genetic relationships among Thai gibbon species using AFLP markers. (scialert.net)
  • Wrensch suggested that once these or similar molecular markers are accepted by clinicians as part of the classification system, "it may make a great deal of difference in treatment approach for individual patients. (eurekalert.org)
  • In the long run, studies that demonstrate a genetic basis for FSGS may help us identify patients earlier and may lead to improved therapies. (clinicaltrials.gov)
  • But knowing individuals' genetic risk could allow clinicians to identify high-risk patients and screen them at a younger age and more frequently, while those with lower risk may need less-frequent screening, Simard says. (theglobeandmail.com)
  • 11 Genetic mapping involved a comparison of HLA genotypes for 44 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis with those of 101 controls who had taken carbamazepine for at least 3 months without development of any skin reaction, and 93 healthy individuals. (mja.com.au)
  • The Xpert Carba-R Assay tests specimens directly taken from patients, which are usually obtained by rectal swabs, for the presence of five different genetic markers that are associated with carbapenemase, the enzyme produced by CRE. (fda.gov)
  • The challenge became how to find a way to exploit this genetic deficiency to better treat these patients. (mcgill.ca)
  • Identifying this genetic marker continues to move toward precision medicine that we are seeing today, where health care providers can develop specific treatment plans based on the individual needs of patients," Dunn said in the press program. (healio.com)
  • The number of patients who died was also slight in cases where one or the other marker was found. (southlakeoncology.com)
  • When patients presented with both markers, however, the mortality rate rose to nearly 23 percent. (southlakeoncology.com)
  • Technically, the team in which the Spanish expert works has demonstrated in mice that a population of superficial neurons in the spinal cord controls an epigenetic marker known as pS10H3. (medindia.net)
  • It's also the first demonstration that a DNA tag called an epigenetic marker can predispose an individual to addiction and relapse. (technologynetworks.com)
  • 1 kb, CNVs are the most common type of variations in genetic structure. (medpagetoday.com)
  • The most likely area of DNA for genetic variations that predispose to drug hypersensitivity reactions is the human leukocyte antigen (HLA) region ( Box 1 ). (mja.com.au)
  • If that great-grandmother happened to have the genetic variations that have been labeled A, B, C, D, or X, then, by having the same mtDNA yourself, you will have inherited a "Native American" mtDNA marker. (councilforresponsiblegenetics.org)
  • W. Okello-Anyanga, K. Hansel-Hohl, A. Burg, S. Gaubitzer, P. R. Rubaihayo, J. Vollmann, P. T. Gibson, S. Fluch, E. M. Sehr (2017) Towards the selection of superior sesame lines based on genetic and phenotypic characterization for Uganda. (ait.ac.at)
  • In this article, the common uses and potential applications of different retrotransposon-based marker types in agricultural biotechnology will be discussed. (doaj.org)
  • A team of scientists from UC San Francisco and Mayo Clinic has shown that using just three molecular markers will help clinicians classify gliomas - the most common type of malignant brain tumors - more accurately than current methods. (eurekalert.org)
  • The scientists found that among grade II and III tumors, 29 percent were "triple positive," showing all three markers. (eurekalert.org)
  • They targeted markers linked to (1) central nervous system toxicity with efavirenz, (2) Gilbert syndrome with atazanavir, (3) cardiovascular disease with lopinavir, (4) renal proximal tubulopathy with tenofovir, and (5) hypersensitivity to abacavir. (natap.org)
  • The species now only exists in captivity, and there is a substantial risk of genetic drift due to inbreeding and interspecific crossing. (innovations-report.com)
  • However, the usefulness of information from a sparse marker map in outbreeding species is limited because the linkage phase between a marker and QTL must be established for every family in which the marker is to be used for selection. (genetics.org)
  • But scientists at The University of Nottingham in the U.K. have identified genetic markers that they think will lead to vital new diagnostics for the condition. (fiercebiotech.com)
  • By identifying new genetic markers associated with breast-cancer risk, scientists envision a future in which a simple genetic test applied to the general population could determine which individuals need earlier and more frequent screening. (theglobeandmail.com)
  • The project, which involved some 550 scientists around the world and was carried out by the OncoArray Consortium, exemplifies the kind of collaborative research involved in pursuing personalized medicine, where treatment and interventions can be tailored to individuals based on their genetic profiles. (theglobeandmail.com)
  • A new genetic marker associated with ovarian cancer risk was recently discovered by an international research group, led by scientists from the Cancer Research Genetic Epidemiology Unit in the United Kingdom. (innovations-report.com)
  • Drs. Marc Goodman, Galina Lurie, Michael Carney, and Keith Terada of the University of Hawai'i at Mânoa's Cancer Research Center of Hawai'i participated in the validation of the discovered genetic marker as a part of the Ovarian Cancer Association Consortium, a worldwide forum of scientists performing ovarian cancer research. (innovations-report.com)
  • An international group of investigators led by scientists at Memorial Sloan Kettering Cancer Center (MSKCC) and the National Cancer Institute has identified a new genetic marker of risk for breast cancer . (mskcc.org)
  • A genetic marker is a trait transmitted from parent to child, thus potentially permitting the reconstruction of patterns of descent on the basis of its distribution among population members. (encyclopedia.com)
  • A common genetic marker is less valuable than a rare one, for the simple reason that a match between two samples is more likely to be due to chance, rather than to familial descent, if the genetic marker is a common one. (encyclopedia.com)
  • however, their concentrations are not necessarily amenable to source apportionment because the markers may differ in prevalence across sources. (epa.gov)
  • This discovery could potentially lead to an early genetic test, which could help reveal those who are most at risk for Alzheimer's - leading to earlier, more effective treatments. (foxnews.com)
  • Much of the genetic research on Alzheimer's centers on amyloid-beta, a key component of brain plaques that build up in the brains of people with the disease. (healthcanal.com)
  • Even so, the results were promising because they showed that if you don't have the genetic marker for Alzheimer's disease, you stand a very good chance of avoiding it altogether by use of the supplement. (inquisitr.com)
  • According to the Forbes report, "it's still possible that starting fish oil supplementation during or before middle age could protect against developing Alzheimer's even for people with the genetic marker. (inquisitr.com)
  • No genetic differences were found between the inermis form, O. ficus-indica f. ficus-indica , and the rewilded spiny one, O . ficus-indica f. amyclaea . (mdpi.com)
  • Torres found that blocking a new genetic marker can reduce the neural activation caused by painful stimuli. (medindia.net)
  • Blood group A phenotype and homozygous plasma haptoglobin (2-2) were found associated with CL(P). The findings suggest that the individuals possessing these markers are more likely to develop congenital CL(P). (biomedsearch.com)
  • The reliability of the inferences derived from any genetic marker is a function of three properties: (1) mode of inheritance, (2) stability, and (3) rarity. (encyclopedia.com)
  • The mode of inheritance of a genetic marker may be quite variable. (encyclopedia.com)
  • Simple sequence repeats (SSRs) are useful molecular markers for genetic mapping and variety identification. (dovepress.com)
  • Genetic markers associated with certain diseases can often be detected in the blood serum, where their presence is used to determine whether a person is at high risk for developing a disease. (yourdictionary.com)
  • Genetic markers associated with certain diseases can be used to determine whether an individual is at risk for developing an inherited disease. (yourdictionary.com)
  • Ethnicity has been associated with the incidence of diseases and consequently it is a cornerstone in medical genetic studies. (scirp.org)
  • Maximum-likelihood models for mapping genetic markers showing segregation distortion. (nih.gov)
  • We show that dominant markers provide very poor information in the case of segregation distortion and, therefore, should be used with circumspection. (nih.gov)
  • Others use nuclear DNA markers from small samples of diverse peoples as a baseline to establish a customer's "racial" affiliation, which simply expresses an overall pattern of similarity to one or more of these standard samples. (encyclopedia.com)
  • Genetic similarity values ranged from 0.074 (between Maple pea NZ and Line 45760) to 0.875 (between Galena and Dakota) with an average of 0.336. (bioone.org)
  • Now we have a genetic marker to potentially help differentiate between transient and persistent wheezers. (sun-sentinel.com)
  • Can genotype records that rely on disjoint sets of markers be linked? (pnas.org)
  • They occur in less than 1 per cent of women, Simard says, whereas some of the newly identified genetic markers are much more common. (theglobeandmail.com)
  • Uniparental markers (on mitochondrial or Y chromosomal DNA) are studied for assessing maternal or paternal lineages . (wikipedia.org)
  • On the mitochondrial DNA, there are a total of five different "haplotypes"(DEFINE), called A, B, C, D, and X, which are increasingly called "Native American markers," and are believed to be a genetic signature of the founding ancestors. (councilforresponsiblegenetics.org)
  • Genetic markers are used in paternity testing, studies of evolution, and evaluating genetic contributions to phenotypes including disease. (yourdictionary.com)
  • Markers such as this one are useful because they may help clinicians distinguish between men who are at risk for earlier onset of disease where intensive screening approaches can be discussed. (biologynews.net)
  • A Salt Lake company, Axial Biotech Inc., has identified specific genetic markers for scoliosis. (deseretnews.com)
  • Therefore, specific likelihood equations have to be developed for each case, including dominant and codominant markers. (nih.gov)
  • The U.S. Food and Drug Administration today cleared for marketing the Xpert Carba-R Assay, an infection control aid that tests patient specimens to detect specific genetic markers associated with bacteria that are resistant to Carbapenem antibiotics. (fda.gov)
  • The vulnerability of individuals to becoming "hooked" on drugs may involve specific genetic factors - both inherited and influenced by drug use. (technologynetworks.com)