A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Any method used for determining the location of and relative distances between genes on a chromosome.
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Genotypic differences observed among individuals in a population.
Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Genetic loci associated with a QUANTITATIVE TRAIT.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
The relationships of groups of organisms as reflected by their genetic makeup.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
A specific HLA-B surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-B*15 allele family.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A plant family of the order Capparales, subclass Dilleniidae, class Magnoliopsida. It is a small family of herbs and shrubs. Some produce GLUCOSINOLATES.
Establishing the father relationship of a man and a child.
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Contamination of bodies of water (such as LAKES; RIVERS; SEAS; and GROUNDWATER.)
The genetic complement of a plant (PLANTS) as represented in its DNA.
The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."
Deoxyribonucleic acid that makes up the genetic material of plants.
An individual having different alleles at one or more loci regarding a specific character.
The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
The mating of plants or non-human animals which are closely related genetically.
The science dealing with the earth and its life, especially the description of land, sea, and air and the distribution of plant and animal life, including humanity and human industries with reference to the mutual relations of these elements. (From Webster, 3d ed)
The most common of the microsatellite tandem repeats (MICROSATELLITE REPEATS) dispersed in the euchromatic arms of chromosomes. They consist of two nucleotides repeated in tandem; guanine and thymine, (GT)n, is the most frequently seen.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
A field of study concerned with the principles and processes governing the geographic distributions of genealogical lineages, especially those within and among closely related species. (Avise, J.C., Phylogeography: The History and Formation of Species. Harvard University Press, 2000)
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
A theorem in probability theory named for Thomas Bayes (1702-1761). In epidemiology, it is used to obtain the probability of disease in a group of people with some characteristic on the basis of the overall rate of that disease and of the likelihood of that characteristic in healthy and diseased individuals. The most familiar application is in clinical decision analysis where it is used for estimating the probability of a particular diagnosis given the appearance of some symptoms or test result.
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
The change in gene frequency in a population due to migration of gametes or individuals (ANIMAL MIGRATION) across population barriers. In contrast, in GENETIC DRIFT the cause of gene frequency changes are not a result of population or gamete movement.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.
Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.
Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
Copies of DNA sequences which lie adjacent to each other in the same orientation (direct tandem repeats) or in the opposite direction to each other (INVERTED TANDEM REPEATS).
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.
A set of statistical methods used to group variables or observations into strongly inter-related subgroups. In epidemiology, it may be used to analyze a closely grouped series of events or cases of disease or other health-related phenomenon with well-defined distribution patterns in relation to time or place or both.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
Any of several large carnivorous mammals of the family CANIDAE that usually hunt in packs.
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
The functional hereditary units of PLANTS.
The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease.
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Computer-based representation of physical systems and phenomena such as chemical processes.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).
Identification of genetic carriers for a given trait.
Vaccines used in conjunction with diagnostic tests to differentiate vaccinated animals from carrier animals. Marker vaccines can be either a subunit or a gene-deleted vaccine.
Allelic variants of the gamma-immunoglobulin heavy chain (IMMUNOGLOBULIN GAMMA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN HEAVY CHAIN GENES.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A technique for identifying individuals of a species that is based on the uniqueness of their DNA sequence. Uniqueness is determined by identifying which combination of allelic variations occur in the individual at a statistically relevant number of different loci. In forensic studies, RESTRICTION FRAGMENT LENGTH POLYMORPHISM of multiple, highly polymorphic VNTR LOCI or MICROSATELLITE REPEAT loci are analyzed. The number of loci used for the profile depends on the ALLELE FREQUENCY in the population.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Sequential operating programs and data which instruct the functioning of a digital computer.
A mutation named with the blend of insertion and deletion. It refers to a length difference between two ALLELES where it is unknowable if the difference was originally caused by a SEQUENCE INSERTION or by a SEQUENCE DELETION. If the number of nucleotides in the insertion/deletion is not divisible by three, and it occurs in a protein coding region, it is also a FRAMESHIFT MUTATION.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
A phylum of bacteria comprised of three classes: Bacteroides, Flavobacteria, and Sphingobacteria.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Deoxyribonucleic acid that makes up the genetic material of protozoa.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The application of molecular biology to the answering of epidemiological questions. The examination of patterns of changes in DNA to implicate particular carcinogens and the use of molecular markers to predict which individuals are at highest risk for a disease are common examples.
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
An individual in which both alleles at a given locus are identical.
Allelic variants of the immunoglobulin light chains (IMMUNOGLOBULIN LIGHT CHAINS) or heavy chains (IMMUNOGLOBULIN HEAVY CHAINS) encoded by ALLELES of IMMUNOGLOBULIN GENES.
A genus of toxic herbaceous Eurasian plants of the Plantaginaceae which yield cardiotonic DIGITALIS GLYCOSIDES. The most useful species are Digitalis lanata and D. purpurea.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)
Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Individuals whose ancestral origins are in the continent of Europe.
Mapping of the KARYOTYPE of a cell.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Elements of limited time intervals, contributing to particular results or situations.
A genus of the family SALMONIDAE (salmons and trouts). They are named for their hooked (onco) nose (rhynchus). They are usually anadromous and occasionally inhabit freshwater. They can be found in North Pacific coastal areas from Japan to California and adjacent parts of the Arctic Ocean. Salmon and trout are popular game and food fish. Various species figure heavily in genetic, metabolism, and hormone research.
Materials used as reference points for imaging studies.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
DNA sequences encoding RIBOSOMAL RNA and the segments of DNA separating the individual ribosomal RNA genes, referred to as RIBOSOMAL SPACER DNA.
The fluctuation of the ALLELE FREQUENCY from one generation to the next.
Erythrocyte isoantigens of the Rh (Rhesus) blood group system, the most complex of all human blood groups. The major antigen Rh or D is the most common cause of erythroblastosis fetalis.
A family composed of spouses and their children.
Individuals whose ancestral origins are in the southeastern and eastern areas of the Asian continent.
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules.
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
An order comprising three families of eukaryotic viruses possessing linear, nonsegmented, positive sense RNA genomes. The families are CORONAVIRIDAE; ARTERIVIRIDAE; and RONIVIRIDAE.
A hereditary disease of the hip joints in dogs. Signs of the disease may be evident any time after 4 weeks of age.
The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.
Databases devoted to knowledge about specific genes and gene products.
Biochemical identification of mutational changes in a nucleotide sequence.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
The total genetic information possessed by the reproductive members of a POPULATION of sexually reproducing organisms.
The chromosomal constitution of cells, in which each type of CHROMOSOME is represented twice. Symbol: 2N or 2X.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Excrement from the INTESTINES, containing unabsorbed solids, waste products, secretions, and BACTERIA of the DIGESTIVE SYSTEM.
A complication of pregnancy in which the UMBILICAL CORD wraps around the fetal neck once or multiple times. In some cases, cord entanglement around fetal neck may not affect pregnancy outcome significantly. In others, the nuchal cord may lead to restricted fetal blood flow, oxygen transport, fetal development, fetal movement, and complicated delivery at birth.
The functional hereditary units of BACTERIA.
The genetic complement of MITOCHONDRIA as represented in their DNA.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Animals which have become adapted through breeding in captivity to a life intimately associated with humans. They include animals domesticated by humans to live and breed in a tame condition on farms or ranches for economic reasons, including LIVESTOCK (specifically CATTLE; SHEEP; HORSES; etc.), POULTRY; and those raised or kept for pleasure and companionship, e.g., PETS; or specifically DOGS; CATS; etc.
The male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans and in some other male-heterogametic species in which the homologue of the X chromosome has been retained.
The intergenic DNA segments that are between the ribosomal RNA genes (internal transcribed spacers) and between the tandemly repeated units of rDNA (external transcribed spacers and nontranscribed spacers).
One of the early purine analogs showing antineoplastic activity. It functions as an antimetabolite and is easily incorporated into ribonucleic acids.
Diminished or failed response of an organism, disease or tissue to the intended effectiveness of a chemical or drug. It should be differentiated from DRUG TOLERANCE which is the progressive diminution of the susceptibility of a human or animal to the effects of a drug, as a result of continued administration.
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Genes that are located on the MITOCHONDRIAL DNA. Mitochondrial inheritance is often referred to as maternal inheritance but should be differentiated from maternal inheritance that is transmitted chromosomally.
A subdiscipline of genetics which deals with the genetic mechanisms and processes of microorganisms.
Application of statistical procedures to analyze specific observed or assumed facts from a particular study.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
An individual that contains cell populations derived from different zygotes.
Enzyme systems containing a single subunit and requiring only magnesium for endonucleolytic activity. The corresponding modification methylases are separate enzymes. The systems recognize specific short DNA sequences and cleave either within, or at a short specific distance from, the recognition sequence to give specific double-stranded fragments with terminal 5'-phosphates. Enzymes from different microorganisms with the same specificity are called isoschizomers. EC 3.1.21.4.
A protozoan parasite that causes vivax malaria (MALARIA, VIVAX). This species is found almost everywhere malaria is endemic and is the only one that has a range extending into the temperate regions.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
A country spanning from central Asia to the Pacific Ocean.
Procedures for identifying types and strains of bacteria. The most frequently employed typing systems are BACTERIOPHAGE TYPING and SEROTYPING as well as bacteriocin typing and biotyping.
Allelic variants of the kappa light chains (IMMUNOGLOBULIN KAPPA-CHAINS) encoded by ALLELES of IMMUNOGLOBULIN LIGHT CHAIN GENES.
A country in northern Africa between ALGERIA and LIBYA. Its capital is Tunis.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A subdiscipline of genetics which deals with the genetic basis of the immune response (IMMUNITY).
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
The total process by which organisms produce offspring. (Stedman, 25th ed)
Abnormal number or structure of chromosomes. Chromosome aberrations may result in CHROMOSOME DISORDERS.
A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).
Tumors or cancer of the PROSTATE.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The human male sex chromosome, being the differential sex chromosome carried by half the male gametes and none of the female gametes in humans.
Methods used for detecting the amplified DNA products from the polymerase chain reaction as they accumulate instead of at the end of the reaction.
Tumors or cancer of the human BREAST.
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A specific pair GROUP C CHROMSOMES of the human chromosome classification.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
A constitution or condition of the body which makes the tissues react in special ways to certain extrinsic stimuli and thus tends to make the individual more than usually susceptible to certain diseases.
The study of chance processes or the relative frequency characterizing a chance process.
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
A plant genus of the family OLEACEAE. Members contain suspensaside.
The pattern of GENE EXPRESSION at the level of genetic transcription in a specific organism or under specific circumstances in specific cells.
Established cell cultures that have the potential to propagate indefinitely.
Mathematical procedure that transforms a number of possibly correlated variables into a smaller number of uncorrelated variables called principal components.
The portion of an interactive computer program that issues messages to and receives commands from a user.
An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).

11q23.1 and 11q25-qter YACs suppress tumour growth in vivo. (1/12529)

Frequent allelic deletion at chromosome 11q22-q23.1 has been described in breast cancer and a number of other malignancies, suggesting putative tumour suppressor gene(s) within the approximately 8 Mb deleted region. In addition, we recently described another locus, at the 11q25-qter region, frequently deleted in breast cancer, suggesting additional tumour suppressor gene(s) in this approximately 2 Mb deleted region. An 11q YAC contig was accessed and three YACs, one containing the candidate gene ATM at 11q23.1, and two contiguous YACs (overlapping for approximately 400-600 kb) overlying most of the 11q25 deleted region, were retrofitted with a G418 resistance marker and transfected into murine A9 fibrosarcoma cells. Selected A9 transfectant clones (and control untransfected and 'irrelevant' alphoid YAC transfectant A9 clones) were assayed for in vivo tumorigenicity in athymic female Balb c-nu/nu mice. All the 11q YAC transfectant clones demonstrated significant tumour suppression compared to the control untransfected and 'irrelevant' YAC transfected A9 cells. These results define two discrete tumour suppressor loci on chromosome 11q by functional complementation, one to a approximately 1.2 Mb region on 11q23.1 (containing the ATM locus) and another to a approximately 400-600 kb subterminal region on 11q25-qter.  (+info)

Superimposed histologic and genetic mapping of chromosome 9 in progression of human urinary bladder neoplasia: implications for a genetic model of multistep urothelial carcinogenesis and early detection of urinary bladder cancer. (2/12529)

The evolution of alterations on chromosome 9, including the putative tumor suppressor genes mapped to the 9p21-22 region (the MTS genes), was studied in relation to the progression of human urinary bladder neoplasia by using whole organ superimposed histologic and genetic mapping in cystectomy specimens and was verified in urinary bladder tumors of various pathogenetic subsets with longterm follow-up. The applicability of chromosome 9 allelic losses as non-invasive markers of urothelial neoplasia was tested on voided urine and/or bladder washings of patients with urinary bladder cancer. Although sequential multiple hits in the MTS locus were documented in the development of intraurothelial precursor lesions, the MTS genes do not seem to represent a major target for p21-23 deletions in bladder cancer. Two additional tumor suppressor genes involved in bladder neoplasia located distally and proximally to the MTS locus within p22-23 and p11-13 regions respectively were identified. Several distinct putative tumor suppressor gene loci within the q12-13, q21-22, and q34 regions were identified on the q arm. In particular, the pericentromeric q12-13 area may contain the critical tumor suppressor gene or genes for the development of early urothelial neoplasia. Allelic losses of chromosome 9 were associated with expansion of the abnormal urothelial clone which frequently involved large areas of urinary bladder mucosa. These losses could be found in a high proportion of urothelial tumors and in voided urine or bladder washing samples of nearly all patients with urinary bladder carcinoma.  (+info)

Multiple target sites of allelic imbalance on chromosome 17 in Barrett's oesophageal cancer. (3/12529)

Twelve Barrett's adenocarcinomas have been analysed for the occurrence of allelic imbalance (LOH) on chromosome 17 using 41 microsatellite markers. This study provides evidence for 13 minimal regions of LOH, six on 17p and seven on 17q. Four of these centre in the vicinity of the known tumour suppressor genes (TSGs) TP53 (17p13.1), NFI (17q11.2), BRCA1 (17q21.1), and a putative TSG (17p13.3). The tumours all displayed relatively small regions of LOH (1-10 cM), and in several tumours extensive regions of LOH were detected. One tumour displayed only two very small regions of LOH; 17p11.2 and 17p13.1. The frequency of allelic imbalance has been calculated based on the LOH encompassing only one minimal region, and based on all the LOH observations. By both evaluations the highest LOH frequencies were found for regions II (p53), III (17p13.1 centromeric to p53), IV (17p12), V (17p11.2) and VII (NF1, 17q11.2). Our data supports the existence of multiple TSGs on chromosome 17 and challenges the view that p53 is the sole target of LOH on 17p in Barrett's adenocarcinoma.  (+info)

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma. (4/12529)

The association of p53 abnormalities with the prognosis of patients with non-small cell lung carcinoma (NSCLC) has been extensively investigated to date, however, this association is still controversial. Therefore, we investigated the prognostic significance of p53 mutations through exons 2 to 11 and p53 protein expression in 103 cases of stage I NSCLC. p53 mutations were detected in 49 of 103 (48%) tumors. Two separate mutations were detected in four tumors giving a total of 53 unique mutations in 49 tumors. Ten (19%) of mutations occurred outside exons 5-8. Positive immunohistochemical staining of p53 protein was detected in 41 of 103 (40%) tumors. The concordance rate between mutations and protein overexpression was only 69%. p53 mutations, but not expression, were significantly associated with a shortened survival of patients (P<0.001). Furthermore, we investigated the correlation between the types of p53 mutations and prognosis. p53 missense mutations rather than null mutations were associated with poor prognosis (P < 0.001 in missense mutations and P=0.243 in null mutations). These results indicated that p53 mutations, in particular missense mutations, rather than p53 expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.  (+info)

p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent. (5/12529)

p73, a novel p53 family member, is a recently identified candidate neuroblastoma (NBL) suppressor gene mapped at chromosome 1p36.33 and was found to inhibit growth and induce apoptosis in cell lines. To test the hypothesis that p73 is a NBL suppressor gene, we analysed the p73 gene in primary human NBLs. Loss of heterozygosity (LOH) for p73 was observed in 19% (28/151) of informative cases which included 92 mass-screening (MS) tumors. The high frequency of p73 LOH was significantly associated with sporadic NBLs (9% vs 34%, P<0.001), N-myc amplification (10% vs 71%, P<0.001), and advanced stage (14% vs 28%, P<0.05). Both p73alpha and p73beta transcripts were detectable in only 46 of 134 (34%) NBLs at low levels by RT-PCR methods, while they were easily detectable in most breast cancers and colorectal cancers under the same conditions. They found no correlation between p73 LOH and its expression levels (P>0.1). We found two mutations out of 140 NBLs, one somatic and one germline, which result in amino acid substitutions in the C-terminal region of p73 which may affect transactivation functions, though, in the same tumor samples, no mutation of the p53 gene was observed as reported previously. These results suggest that allelic loss of the p73 gene may be a later event in NBL tumorigenesis. However, p73 is infrequently mutated in primary NBLs and may hardly function as a tumor suppressor in a classic Knudson's manner.  (+info)

High polymorphism level of genomic sequences flanking insertion sites of human endogenous retroviral long terminal repeats. (6/12529)

The polymorphism at the multitude of loci adjacent to human endogenous retrovirus long terminal repeats (LTRs) was analyzed by a technique for whole genome differential display based on the PCR suppression effect that provides selective amplification and display of genomic sequences flanking interspersed repeated elements. This strategy is simple, target-specific, requires a small amount of DNA and provides reproducible and highly informative data. The average frequency of polymorphism observed in the vicinity of the LTR insertion sites was found to be about 12%. The high incidence of polymorphism within the LTR flanks together with the frequent location of LTRs near genes makes the LTR loci a useful source of polymorphic markers for gene mapping.  (+info)

Structure of cag pathogenicity island in Japanese Helicobacter pylori isolates. (7/12529)

BACKGROUND: cag pathogenicity island (PAI) is reported to be a major virulence factor of Helicobacter pylori. AIM: To characterise cagA and the cag PAI in Japanese H pylori strains. METHODS: H pylori isolates from Japanese patients were evaluated for CagA by immunoblot, for cagA transcription by northern blot, and for cagA and 13 other cag PAI genes by Southern blot. cagA negative strains from Western countries were also studied. Induction of interleukin-8 secretion from gastric epithelial cells was also investigated. RESULTS: All Japanese strains retained cagA. Fifty nine of 63 (94%) strains had all the cag PAI genes. In the remaining four, cag PAI was partially deleted, lacking cagA transcripts and not producing CagA protein. Details of the PAI of these strains were checked; three lacked cagB to cagQ (cagI) and continuously cagS to cag13 (cagII), and the remaining one lacked cagB to cag8. Western cagA negative strains completely lacked cag PAI including cagA. Nucleotide sequence analysis in one strain in which the cag PAI was partially deleted showed that the partial deletion contained 25 kb of cag PAI and the cagA promoter. Interleukin-8 induction was lower with the cag PAI partial deletion strains than with the intact ones. All Japanese cag PAI deleted strains were derived from patients with non-ulcer dyspepsia, whereas 41 of 59 (70%) CagA-producing strains were from patients with peptic ulcers or gastric cancer (p<0.05). CONCLUSIONS: Most Japanese H pylori strains had the intact cag PAI. However, some lacked most of the cag PAI in spite of the presence of cagA. Thus the presence of the cagA gene is not an invariable marker of cag PAI related virulence in Japanese strains.  (+info)

Screening for mutations of the cationic trypsinogen gene: are they of relevance in chronic alcoholic pancreatitis? (8/12529)

BACKGROUND: In hereditary pancreatitis mutations of exons 2 (N21I) and 3 (R117H) of the cationic trypsinogen gene have been described. AIMS: To investigate whether the same mutations can also be found in patients with chronic alcoholic pancreatitis. METHODS: Leucocyte DNA was prepared from 23 patients with chronic alcoholic pancreatitis, 21 with alcoholic liver cirrhosis, 34 individuals from seven independent families with hereditary pancreatitis, and 15 healthy controls. DNA was also obtained from pancreatic tissue (n=7) and from pancreatic juice (n=5) of patients suffering from chronic alcoholic pancreatitis. R117H was detected by restriction digestion with Afl III. N21I was identified by an allele specific polymerase chain reaction (PCR). RESULTS: R117H was detected in four families with hereditary pancreatitis. The N21I mutation was identified in three families. All mutations were confirmed by sequencing of the corresponding DNAs. In patients with chronic alcoholic pancreatitis neither the exon 2 nor exon 3 mutations were present in blood leucocytes, pancreatic juice, or pancreatic tissue. DNA of the patients with alcoholic liver cirrhosis as well as all controls was of wild type. CONCLUSIONS: The allele specific PCR may be used to screen for the N21I mutation of cationic trypsinogen. Both trypsinogen mutations were found in hereditary pancreatitis but do not seem to be major pathogenic factors in chronic alcoholic pancreatitis.  (+info)

Simple Sequence Length Polymorphisms (SSLPs) are used as genetic markers with polymerase chain reaction (PCR). An SSLP is a type of polymorphism: a difference in DNA sequence amongst individuals. SSLPs are repeated sequences over varying base lengths in intergenic regions of deoxyribonucleic acid (DNA). Variance in the length of SSLPs can be used to understand genetic variation between two individuals in a certain species. An example of the usage of SSLPs (microsatellites) is seen in a study by Rosenberg et al., where SSLPs were used to cluster different continental races. The study was critical to Nicholas Wades New York Times Bestseller, Before the Dawn: Recovering the Lost History of Our Ancestors. Rosenberg studied 377 SSLPs in 1000 people in 52 different regions of the world. By using PCR and cluster analysis, Rosenberg was able to group individuals that had the same SSLPs . These SSLPs were extremely useful to the experiment because they do not affect the phenotypes of the individuals, ...
A population size of 100 was simulated for 10 biallelic or multiallelic marker loci for 100 generations before pedigree recording. In each generation, the number of male and female parents was 50 and their alleles were transmitted to descendants on the basis of Mendelian segregation using the gene-dropping method (MacCluer et al. 1986). Parents were randomly mated with a total of two offspring for each of 50 mating pairs. In the multiallelic marker model (e.g., microsatellites), the number of alleles assumed in each marker locus was 4 and base allele frequencies were all at 0.25. In the biallelic marker model (e.g., SNP), the number of alleles was 2 and starting allele frequencies were 0.5. The marker alleles were mutated at rates of 4 × 10−4 per generation in multiallelic markers (Dallas 1992; Weber and Wong 1993; Ellegren 1995) and 2.5 × 10−8 per generation in biallelic markers (Nachman and Crowell 2000). A mutated locus was switched between the two existing alleles for biallelic markers ...
A linkage map of cacao based on codominant markers has been constructed by integrating 201 new simple sequence repeats (SSR) developed in this study with a number of isoenzymes, restriction fragment...
A maximum-likelihood approach is used in order to estimate recombination fractions between markers showing segregation distortion in backcross populations. It is assumed that the distortions are induced by viability differences between gametes or zygotes due to one or more selected genes. We show th …
The HCP5 genetic marker was not a good predictor of quitting abacavir, perhaps because the study considered stopping abacavir for any reason, not just the hypersensitivity reaction, and because people in Switzerland started getting HLA-B*5701 screening before beginning abacavir during this period. For the other four drugs, hazard ratios adjusted for other risk factors found that genetic markers independently predicted stopping efavirenz (adjusted hazard ratio [aHR] 3.10, 95% confidence interval [CI] 1.48 to 6.46, P = 2.59 x 10(-3) and atazanavir (aHR 7.31, 95% CI 2.86 to 18.72, P = 3.30 x 10(-6)). There was a strong trend toward an independent effect of genetic markers on quitting tenofovir (aHR 2.30, 95% CI 0.99 to 5.31, P = 0.052) but not lopinavir (aHR 1.42, 95% CI 0.62 to 3.25, P = 0.41 ...
Breeding technique allows farmers to conventionally breed plants based on genetic markers; GMOs are unnecessary, costly, dangerous and now obsolete
An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific journals.
Detail záznamu - An Improved Consensus Linkage Map of Barley Based on Flow-Sorted Chromosomes and Single Nucleotide Polymorphism Markers - Detail záznamu - Knihovna Akademie věd České republiky
A specific sequence of DNA at a known location on a chromosome. There are many genetic markers on each chromosome. Genetic markers and genes that are close to each other on a chromosome are usually inherited (passed from parent to child) together. This may help researchers find a gene near a marker that may cause a certain disease or trait within a family. Examples of genetic markers are single polymorphism nucleotides (SNPs) and microsatellites ...
Genome informatics company Cypher Genomics, Inc. will use its diagnostics technology to assist Celgene in discovering novel genomic biomarkers that identify patients who respond well to specific drugs. The collaboration comes during industrys push in increasing efforts in precision medicine, tailoring therapy based on a patients genetic makeup. The companies announced …. ...
Sheindlin will be joined on Judy Justice by a new television bailiff and stenographer. Sarah Rose, a law clerk and Sheindlins granddaughter, will be a legal analyst.. Shes smart, sassy and opinionated, her grandmother said. Who knows where she gets those traits?. Filming for the old Judge Judy ended after CBS bought the shows old episodes from Sheindlin. That enabled CBS to continue selling rights to air them through the syndication market without having to pay her to make new episodes. Sheindlin was widely believed to be the countrys highest-paid television star.. Sheindlin, a former New York judge, was also said to be unhappy with CBS for giving priority time slots to Drew Barrymores new show at the expense of Hot Bench, another court show that Sheindlin created, according to The Wall Street Journal.. We had a nice marriage, Sheindlin told the Journal earlier this year. Its going to be a Bill and Melinda Gates divorce.. Two of her longtime producers, Randy Douthit and Amy ...
Granddaughter Age 10 Birthday Cards, size 9x6 *RANDOM SELECTION From publishers such as: IC&G, Noel Tatt, Regal Publishing, Wishing Well, Nigel Quiney Select the quantity you require and we will pick as many different designs as possible. *Images are samples designs and may not be included in your selection.
Woman jailed in granddaughters slaying ruled sane in 2015 - AP News: LOS ANGELES (AP) - A California woman suspected of fatally .12/18/2017 18:39:01PM EST.
Jack Banda of Marshfield watched his daughter, Nicole Puzzo, struggle to carry his granddaughter, Stella, onto the beach. Stella, now four, has cerebral palsy. A retired engineer, Banda designed a child-size
Dallas Green speaks about his 9-year-old granddaughter, Christina Taylor Green, who was a victim in the Arizona shooting tragedy last month. - Philly.com, Philadelphia Philly.com
Testing genetic markers for Hardy-Weinberg equilibrium is an important issue in genetic association studies. The HardyWeinberg package o ers the classical tests for equilibrium, functions for power computation and for the simulation of marker data under equilibrium and disequilibrium. Functions for testing equilibrium in the presence of missing data by using multiple imputation are provided. The package also supplies various graphical tools such as ternary plots with acceptance regions, log-ratio plots and Q-Q plots for exploring the equilibrium status of a large set of diallelic markers. Classical tests for equilibrium and graphical representations for diallelic marker data are reviewed. Several data sets illustrate the use of the package ...
Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. In phase l, the plan isto describe a method to identify large-numbers of the new markers and to isolate and characterizeseveral examples. In addition, the basic expectations that they will produce precise amplificationproducts and that their allelic content can be determined more efficiently, safely, and cheaply than othersystems will be demonstrated. This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large number of the markers, more thorough ...
A summary of the results for AFLP, SNP, and microsatellite data sets in Tables 3-5⇑ is shown. The PPV is defined as the proportion of markers detected as being under selection that are correctly classified. Results are presented using cutoff values that lead to a 5% total false-positive rate for both the reversible-jump (RJ) method introduced here and the informal criterion (IC) originally proposed by Beaumont and Balding (2004). ...
Trans2K® DNA Marker,DNA markers,DNA Molecular Weight Standards,Products,Beijing TransGen Biotech Co.Ltd,OverviewContents& storageCitations & referencesRelated ImagesDownloadOverviewDescriptionTrans2K® DNA Marker is a premixed, ready-to-load
Blank lines in the input file are ignored. The file is organized in several fields separated by one or more space or TAB characters. The first non-blank line gives the start position of the DNA fragment to be drawn after the keyword Start. The end position is on the second line following the keyword End. Then, one or more groups (up to a maximum of 20) of genetic markers are defined. Each group begins with a line consisting of the keyword group and ends with a line consisting of the keyword endgroup. If desired, a group name can be given on the very next line but will not be displayed (only for compatibilty with lindna). Next, the individual markers (up to a maximum of 1000) of the group are described. Each marker begins with a line consisting of the keyword label and ends with a line consisting of the keyword endlabel. Do not start a new marker (by using a label line) before you have closed the previous marker (by using an endlabel line). You must end a previous marker ...
Blank lines in the input file are ignored. The file is organized in several fields separated by one or more space or TAB characters. The first non-blank line gives the start position of the DNA fragment to be drawn after the keyword Start. The end position is on the second line following the keyword End. Then, one or more groups (up to a maximum of 20) of genetic markers are defined. Each group begins with a line consisting of the keyword group and ends with a line consisting of the keyword endgroup. If desired, a group name can be given on the very next line but will not be displayed (only for compatibilty with lindna). Next, the individual markers (up to a maximum of 1000) of the group are described. Each marker begins with a line consisting of the keyword label and ends with a line consisting of the keyword endlabel. Do not start a new marker (by using a label line) before you have closed the previous marker (by using an endlabel line). You must end a previous marker ...
It can be described as some sort of variation present can arise due to mutation or alteration in the genomic loci that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (SNP), or a long one, like microsatellites. Some commonly used types of genetic markers are RFLP, VNTR, Microsatellite Polymorphism, SNP, STR ...
reference to the John Coltrane composition Mr. P.C. The song was written for Paul Chambers, Tranes long-time bassist, and I realized last night how much Chambers is the star of that piece, driving everyone in the band to perform fabulous solos without being featured himself. Thats a jazz thing. That is exactly what Nan did each week with her solid devotion to me and my colleagues: she pushed the music along, influencing us without getting in the way. Nan fell by the station for a visit once when her granddaughter was in town from California. Nan was dressed like Norma Desmond, with black sunglasses and a brocade wrap around her head. I know she was training her granddaughter to listen to jazz by insisting on the outing. The two of them sat quietly in the studio and watched me program the entire afternoon. From then on, the weekly letters not only included stories from Nans active memory and tales of her daily activities, Nan also kept me apprised of the goings on of her beloved granddaughter. ...
Trans2K® Plus II DNA Marker,DNA markers,DNA Molecular Weight Standards,Products,Beijing TransGen Biotech Co.Ltd,OverviewContents& storageCitations & referencesRelated ImagesDownloadOverviewDescriptionTrans2K® Plus II DNA Marker is a premixed
A fragment of genetic material associated with a certain location in the genome is known as molecular marker. Molecular markers have been useful in determining hybrid purity, identifying genotypes, discovering genes linked to known markers and also enable an in-depth analysis of quantitative traits, allowing interesting alleles to be found in wild or cultivated germplasm. Due to its heritability and relatively easy to assay, made DNA based markers more advantageous than the other markers. The predominate sequence based markers like Single Nucleotide Polymorphisms (SNPs), Simple Sequence Repeats (SSRs) and high throughput DArT assays are widely used in the genetic analysis.. This portal provides the convenient link to molecular marker resources which are identified and validated by IBP partners and collaborators or available in public domain to make easier to the researchers.. To access Molecular resources, click on the appropriate area in the sidebar on the left. For additional information and ...
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy ...
Rheenen, H A van and Moss, J P and Kapoor, R K and Seetharama, N and Davies, D R and Ellis, T H N and Poyser, S and Loader, P A and Knox, M (1996) The development and exploitation of novel genetic markers in the improvement of chickpea and pigeonpea. Project Report. DFID, UK. ...
The largest gene-probing study ever done has fished out dozens of new genetic markers that flag a person's susceptibility to breast, ovarian and
The largest gene-probing study ever done has fished out dozens of new genetic markers that flag a person's susceptibility to breast, ovarian and
beginning-of-information marker вчт. маркер начала информации beginning-of-tape marker вчт. маркер начала ленты boundary marker ограничительный знак marker закладка (в книге) marker клеймовщик; клеймовщица marker клеймовщик marker школ. лицо, отмечающее присутствующих учеников; преподаватель, проверяющий письменные работы marker вчт. маркер marker маркер marker горн. маркирующий горизонт; not a marker to (или on) разг. ничто по сравнению с; = в подметки не годится marker маркер marker амер. мемориальная доска marker горн. маркирующий горизонт; not a marker to (или on) разг. ничто по сравнению с; = в подметки не ...
I cant believe the hatchet job mainstream reporting does on the effectiveness and safety of nutritional supplements. The idea of health and illness is very complicated, which these reports seldom acknowledge. Just like prescribed drugs, not everything is going to work for every person. If fact, the newest research is on genetic markers showing whether or not new drugs will work on the individual person. Medicine knows there are many cofactors that go hand in hand with any illness as well as usefulness of medications. Id add supplements to the list.. As for genetics, something has to flip the genetic switch for illness to happen. The thing that flips or stops the switch is called a cofactor. As for the role of the dice, chance does come into play, but cofactors are a big player as well. Here are some examples according to Julian Whittaker, MD. He says in his newsletter that if everyone 65 and older took calcium and vitamin D, about 776,000 hospitalizations for hip fractures could be avoided. He ...
Date: January 28, 2021 Time: 7:00am (PST), 10:00am (EST) Many of the newly recognized clinically significant genetic markers in pediatric leukemias cannot be reliably detected by routine dia
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Only ~50% of the SNPs detected using raw data coincide between SMA and Blossoc methods. This percentage increased to 67% when using corrected data. The disagreement between the corrected methods was due to 4 SNPs: SNP 331 was detected with SMA (QxPak). This SNP showed high LD with SNP 402 (D ≈ 1, r2 = 0.3), which was highly associated with the phenotype. The equivalent SNP in the SMA raw (323) showed low BPP (0.1). Therefore, SNP 331 is probably a false positive. SNP 3952 was detected with Blossoc and also with SMA raw (BPP = 0.99), suggesting that it is a true QTL. The SNP identified in the beginning of Chromosome 3 (2133) by the SMA method (BPP = 0.89) was also detected with Blossoc on raw data, but was not selected with Blossoc on corrected data. This SNP showed a well defined peak with corrected Blossoc, close to the significance threshold (HQ = 13). Therefore, SNP 2133 is probably also a true QTL. These results indicate that the thresholds defined here for both SMA and Blossoc on ...
This article takes a quantitative approach to the grammar of English two-part discourse marker sequences like oh well, you know I mean, etc. We investigate the internal ordering preferences of such sequences in spoken American English corpus data from the perspective of grammaticalization. From this perspective, the development of many discourse markers can be understood as involving a process of increasing syntactic de-categorialization (Hopper 1991) as the grammaticalizing element loses its original grammatical constraints and comes to function as a marker at the level of discourse. We test the hypothesis that discourse marker grammaticalization results in largely unconstrained ordering possibilities. Our analysis shows that, on the contrary, discourse marker sequencing is highly constrained. We interpret these constraints in terms of Auers (1996) model of discourse marker grammaticalization. Discourse marker sequencing is characterized by strong persistence of a markers original syntactic category
The study, published in the February issue of the American Journal of Human Genetics, involved 3,636 people enrolled in a large trial on the genetics of hypertension. To see whether genetic markers correspond to the standard racial categories, the scientists first analyzed the volunteers DNA, identifying which genetic markers they carried. They then used a computer program to cluster people based on genetic similarities; those who shared genetic markers were grouped together. Finally, the scientists compared those groupings with the volunteers self-identified race. The result: people who considered themselves white had been grouped by the computer, based on their genetic markers, in one cluster, while people who consider themselves African-American had been grouped in a second, different cluster ...
This is the first recorded adventure featuring James Allenvale Bunduki Gunn, the second adopted son of Tarzan, Lord Greystoke. Dawn Drummond-Clayton, the granddaughter of John Korak Drummond-Clayton, is also featured. Story by J.T. Edson in J.T.s Hundredth. 1972 DEATH TO SIMBA NYUSE This is the first recorded adventure of Dawn Drummond-Clayton, the daughter of Armand John and Hazel Drummond-Clayton, and the granddaughter of John Korak Drummond-Clayton. There is also a reference to Sanders of the River. Story by J.T. Edson in J.T.s Ladies. John Korak Drummond-Clayton was the first adopted son of Tarzan and the biological brother of Hugh Bulldog Drummond. The Sanders of the River series was written by Edgar Wallace. November 1972 - The Godwulf Manuscript, the first recorded case of Boston private eye Spenser, as narrated by Spenser and edited by Robert B. Parker. Spenser is the nephew of Philip Marlowe. May 1973 - Policeman Neil Howie travels to the Scottish isle of Summerisle to solve ...
Another thing that was not helpful was my co-worker bursting into the cubicle where I was talking with a colleague and waving around the card she got for the birth of her granddaughter, which featured a disturbing photo of a babys head being held by two hands, taken from the top of the head (Note to everyone I know: If I ever find myself holding a baby that is mine and am lucky enough to get a congratulations card from you, please do not pick the one featuring one or more babies in unnatural or vaguely humiliating positions or outfits. This includes being dressed up like flowers or animals. This practice is not okay and to my mind should be banned by law.). Im not sure what her point was in showing this to us, although my sensitive/vaguely human side does see that one might be excited about a granddaughter. But still. I just really, really do not need to be reminded about my infertility while Im at work trying to forget about it. Can we all agree to that? Yeah, thanks ...
article{b12300dc-2501-4695-a587-8e7248e6b8db, author = {Bjartell, Anders}, issn = {1873-7560}, language = {eng}, pages = {29--31}, publisher = {Elsevier}, series = {European Urology}, title = {Genetic Markers and the Risk of Developing Prostate Cancer.}, url = {http://dx.doi.org/10.1016/j.eururo.2011.03.005}, volume = {60}, year = {2011 ...
The cagefighter looked excited, but exhausted, as he welcomed his parents Carol and Bob to the Essex home he shares with fiancée Chantelle Houghton.
2 Answers (question resolved) - Posted in: oxygen, baby - Answer: The doctor would have known the baby was in distress long before the 6 hr ...
As mentioned elsewhere in this document, in the clinical research process and assistance it will be essential the use of genetic biomarkers, this will allow to generate drugs for groups of patients (stratification) or in some cases individualization. For the current Clinical Test concept, knowledge of the genetic profile can help to avoid interactions with other drugs. From the assistance point of view it is essential to generate an assistance model that stratifies / personalizes the prescription. Among the genetic markers, those that determine the metabolic capacity are the most studied and those most included in the regulation framework. However, one of the great problems is the extrapolation of the phenotype data from the genotype, therefore, it is necessary to generate a new algorithm that allows qualitative information to be transformed into quantitative information, something that can be done from the existing data in the literature and that generated within the project. The possibility of ...
University of Chicago researchers said they have identified a genetic marker that will help identify children who are most likely to develop asthma after they catch a cold
The IP Industry Base is a public available database about the global market of IP practitioners. Currently is provides high-quality profiles of more than 4900 companies, 15620 professionals and 4260 places. The service of the IP Industry Base is dedicated to technology managers, IP professionals and IPR academia. The open data of the IP Industry Base aims to create transparency for the market of IP practitioners.
Gene variants analyzed refers to the total number of variants in our database. Gene variants present in your data will always be either equal to or less than the gene variants analyzed, since different companies test for different numbers of gene markers. ...
markers - MedHelps markers Center for Information, Symptoms, Resources, Treatments and Tools for markers. Find markers information, treatments for markers and markers symptoms.
Geneseeq offers analytically and clinically validated companion diagnostic tests to detect genetic biomarkers to help patients access precision oncology treatment
Etc. [34, 35]. However, it still remains challenging to identify one single marker or several combined markers to specifically identify all the CSCs in ovarian tumor, and the exact roles of these `stemness related markers, are still poorly understood due to either a current lack of understanding...
Sclerostin is a potent inhibitor of Wnt signaling and bone formation. However, there is currently no information on the relation of circulating sclerostin levels to age, gender, or bone mass in humans. Thus we measured serum sclerostin levels in a population-based sample of 362 women [123 premenopausal, 152 postmenopausal not on estrogen treatment (ET), and 87 postmenopausal on ET] and 318 men, aged 21 to 97 years. Sclerostin levels (mean ± SEM) were significantly higher in men than women (33.3 ± 1.0 pmol/L versus 23.7 ± 0.6 pmol/L, p , .001). In pre- and postmenopausal women not on ET combined (n = 275) as well as in men, sclerostin levels were positively associated with age (r = 0.52 and r = 0.64, respectively, p , .001 for both). Over life, serum sclerostin levels increased by 2.4- and 4.6-fold in the women and men, respectively. Moreover, for a given total-body bone mineral content, elderly subjects (age ≥ 60 years) had higher serum sclerostin levels than younger subjects (ages 20 to 39 ...
Several molecular marker systems have been developed for assessing genetic diversity in crop germplasm collections. A trade-off often exists between the number of loci that can feasibly be sampled by a marker system and the amount of information provided by each locus. We compared the usefulness of two marker systems for revealing genetic diversity and population structure in cassava (Manihot esculenta Crantz): simple sequence repeats (SSRs) and diversity array technology (DArT) markers. DArTs survey many more loci per reaction than do SSRs; however, as bi-allelic, dominant markers, DArTs provide less polymorphism information per locus. Genetic differentiation was assessed in a randomly selected set of 436 cassava accessions, consisting of 155 African and 281 Latin American accessions. A genome-wide set of 36 SSR markers and a DArT array of approximately 1000 polymorphic clones were used to assess genetic diversity and differentiation. Cluster analyses were performed using principal coordinate ...
Background Genetic markers and linkage mapping are basic prerequisites for marker-assisted selection and map-based cloning. In the case of the key grassland species Lolium spp., numerous mapping populations have been developed and characterised for various traits. Although some genetic linkage maps of these populations have been aligned with each other using publicly available DNA markers, the number of common markers among genetic maps is still low, limiting the ability to compare candidate gene and QTL locations across germplasm. Results A set of 204 expressed sequence tag (EST)-derived simple sequence repeat (SSR) markers has been assigned to map positions using eight different ryegrass mapping populations. Marker properties of a subset of 64 EST-SSRs were assessed in six to eight individuals of each mapping population and revealed 83% of the markers to be polymorphic in at least one population and an average number of alleles of 4.88. EST-SSR markers polymorphic in multiple populations ...
Scientists from an international consortium have identified a large number of new genetic markers that predispose individuals to lupus.
To increase the utility of the previously constructed physical map of the chromosome of Neisseria gonorrhoeae FA1090, 28 additional genetic markers were localized on the map. Cloned gonococcal genes were used to probe Southern blots of restriction enzyme-digested DNA separated on pulsed-field gels, thus identifying the fragment in each of several digests to which the probe hybridized and the map location of each gene. The addition of the new markers brings the total number of mapped loci for this strain to 68; the locations of all of those markers on the updated map are shown. ...
A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species. It can be described as a variation (which may arise due to mutation or alteration in the genomic loci) that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (single nucleotide polymorphism, SNP), or a long one, like minisatellites. For many years, gene mapping was limited to identifying organisms by traditional phenotype markers. This included genes that encoded easily observable characteristics such as blood types or seed shapes. The insufficient number of these types of characteristics in several organisms limited the mapping efforts that could be done. This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation). Some commonly used types of genetic markers are: RFLP (or Restriction fragment ...
The development of array-based high-throughput genotyping methods created significant opportunities to increase the number of genetic populations for linkage analysis. In the present study, a strategy was proposed for mapping QTLs (quantitative trait loci) based on DArT (diversity arrays technology) genotyping system. A consensus linkage map was constructed with both DArT and SSR markers by utilizing a subgroup DH population, and a second linkage map was constructed with SSR markers alone and a more extensive full DH population. Resistance to barley net-type net blotch disease was analyzed using the subpopulation data with the high-density consensus linkage map and the full-population data with the low-density SSR linkage map, respectively. Two interactive QTLs were detected either by the sub- or full population. Simulation studies were conducted to validate the strategy presented in this chapter. In addition, a computer program written in C++ is freely available on the web to deal with the data ...
Introduction. Genetic linkage maps have been obtained for several plant species and are the basis for advanced genetic studies that provide a better understanding of the inheritance, identification and isolation of genes (Roose et al., 2000). Cloning and gene insertion through genetic transformation have been widely used in species with well-defined genetic maps (Gmitter Jr. et al., 1996).. Different types of molecular markers have been used to obtain genetic linkage maps. Molecular markers are used because they are highly polymorphic and are not influenced by the environment. Among these, random amplified polymorphic DNA (RAPD) markers are the most common because the technique is easy, inexpensive, uses a low amount of genomic DNA, and produces markers that are highly polymorphic and that represent the whole genome (Ferreira and Grattapaglia, 1998). RAPD markers are detected by the random amplification of genomic DNA fragments of different sizes through the polymerase chain reaction (PCR) ...
Simple sequence repeats (SSRs) or microsatellites were tandemly arranged repeats of short DNA motifs (1-6 nucleotides long), which extensively distributed in eukaryotes including the plants, animals and microorganisms, as well as in some prokaryotes [1]. SSRs were commonly regarded as genomic junk with no significant role as genomic information in a long time until the more utilizing of SSR repeat-number variation and accumulating evidence to support the hypothesis that SSRs could play a positive role in adaptive evolution [2-4]. For assaying genetic variation, SSRs markers based on the repeat number variation were showing significant advantages over the variety of other molecular markers, including restriction fragment length polymorphisms (RFLPs), random amplification of polymorphic DNA (RAPD), and amplified fragment length polymorphisms (AFLPs) [5-7]. As a codominant marker, SSRs have proven to be highly polymorphic, easily reproducible, low costing, facility amplified, and not specifically ...
To facilitate mapping of the cystic fibrosis locus (CF) and to isolate the corresponding gene, we have screened a flow-sorted chromosome 7-specific library for additional DNA markers in the 7q31-q32 region. Unique (single-copy) DNA segments were selected from the library and used in hybridization analysis with a panel of somatic cell hybrids containing various portions of human chromosome 7 and patient cell lines with deletion of this chromosome. A total of 258 chromosome 7-specific single-copy DNA segments were identified, and most of them localized to subregions. Fifty three of these corresponded to DNA sequences in the 7q31-q32 region. Family and physical mapping studies showed that two of the DNA markers, D7S122 and D7S340, are in close linkage with CF. The data also showed that D7S122 and D7S340 map between MET and D7S8, the two genetic markers known to be on opposite sides of CF. The study thus reaffirms the general strategy in approaching a disease locus on the basis of chromosome ...
We present a genetic map for Xenopus tropicalis, consisting of 2886 Simple Sequence Length Polymorphism (SSLP) markers. Using a bioinformatics-based strategy, we identified unique SSLPs within the X. tropicalis genome. Scaffolds from X. tropicalis genome assembly 2.0 (JGI) were scanned for Simple Sequence Repeats (SSRs); unique SSRs were then tested for amplification and polymorphisms using DNA from inbred Nigerian and Ivory Coast individuals. Thus identified, the SSLPs were genotyped against a mapping cross panel of DNA samples from 190 F2 individuals. Nearly 4000 SSLPs were genotyped, yielding a 2886-marker genetic map consisting of 10 major linkage groups between 73 and 132cM in length, and 4 smaller linkage groups between 7 and 40cM. The total effective size of the map is 1658cM, and the average intermarker distance for each linkage group ranged from 0.27 to 0.75cM. Fluorescence In Situ Hybridization (FISH) was carried out using probes for genes located on mapped scaffolds to assign linkage ...
The field of molecular phylogenetics has benefited greatly from the recent advances of modern sequencing approaches that allow for the generation of large genomics data sets Nonetheless a lack of suitable genetic markers and incomplete taxon sampling remain common problems in studies of evolutionary relatedness. Most phylogenetic studies are based on mitochondrial DNA (mtDNA) because information about the nuclear genome and strategies to develop new genetic markers are often not available. The use of appropriate genetic markers and the inclusion of both a geographically and phylogenetically comprehensive taxon sampling are required for adequately reconstructing evolutionary histories among different taxa. This is particularly true for studies of recent diversification. Mayflies (Ephemeroptera) are ancient freshwater insects, dating back more than 300 million years, but at the same time have been reported to successfully colonize and diversify on recently formed Atlantic oceanic islands. This combination
Development of DNA markers in forest genetics has overcome the limitations on the number of the used to date morphological and biochemical markers and provided the tools that study variation in coding, non-coding and highly variable regions of both nuclear and organelle (chloroplast and mitochondrial) genomes. In phylogeografic and phylogenetic studies of tree populations as well as gene flow, organelle genomes and highly variable genetic markers proved to be highly informative. Many genetic markers belong to so-called anonymous DNA marker type. Techniques based on these markers are: microsatellites or simple sequence repeats (SSRs), restriction fragment length polymorphisms (RFLPs), random amplified polymorphic DNA (RAPDs), and amplified fragment length polymorphisms (AFLPs). These marker types generally measure neutral DNA variation. They proved to be very useful (with different efficiency) in the analyses of phylogenetic relationships, population structure, mating system, gene flow, parental ...
A 77-year-old man killed in a crash involving a Plymouth Police Department squad car was on his way to a memorial for his granddaughter, who died by suicide over the weekend, according to loved ones.
Fed up with unreturned calls to the FDA, Frank LaFountain drove himself to Washington, DC on Tuesday in a last-ditch attempt to save the life of his 12-year-old granddaughter, McKenzie Lowe.
Michelle Sears, a 44-year-old Sarasota granny, is accused of bringing along her 6-year-old granddaughter while she did drug deals, according to an arrest affidavit from the Sarasota Couonty Sheriff's Office. A deputy had stopped Sears for driving with a suspended license. When the deputy asked Sears...
Schizophrenia is a complicated disease that often appears in early adulthood. Although scientists have not traced the genetic causes, more than 80% of schizophrenia cases are considered to have a hereditary cause. In a…
After testing several genome complexity reduction methods we identified the PstI/TaqI method as the most effective for Eucalyptus and developed 18 genomic libraries from PstI/TaqI representations of 64 different Eucalyptus species. A total of 23,808 cloned DNA fragments were screened and 13,300 (56%) were found to be polymorphic among 284 individuals. After a redundancy analysis, 6,528 markers were selected for the operational array and these were supplemented with 1,152 additional clones taken from a library made from the E. grandis tree whose genome has been sequenced. Performance validation for diversity studies revealed 4,752 polymorphic markers among 174 individuals. Additionally, 5,013 markers showed segregation when screened using six inter-specific mapping pedigrees, with an average of 2,211 polymorphic markers per pedigree and a minimum of 859 polymorphic markers that were shared between any two pedigrees ...
BEHEREGARAY, L. B., SCHWARTZ, T. S., MÖLLER, L. M., CALL, D., CHAO, N. L. and CACCONE, A. (2004), A set of microsatellite DNA markers for the one-lined pencilfish Nannostomus unifasciatus, an Amazonian flooded forest fish. Molecular Ecology Notes, 4: 333-335. doi: 10.1111/j.1471-8286.2004.00687.x ...
After accounting for the larger physical size of the RGSC 6.0/rn6 rat genome build (2,619 Mb) compared with the original Baylor 3.4/rn4 rate genome build (2,554 Mb), the increased size of the rat genetic map (1,708 cM) is proportional to the original Jensen-Seaman map (1,542 cM). Thus, although the coordinates of highly recombinant regions in the rat genome were refined in the revised rat genetic map, the sex-averaged genomewide recombination rates did not change (0.66 cM/Mb vs. 0.65 cM/Mb). Although the genomewide recombination rates did not change, fine-scale localization of highly recombinant regions differed between the Jensen-Seaman map and the revised rat genetic map. One potential reason for the refined localization of highly recombinant regions in the revised rat genetic map is the greater potential of genetic variation due to the possibility of eight informative HS founder haplotypes per genomic position, whereas prior rat genetic maps relied on crosses between two parental strains with ...
We report the establishment of a hybridization-based marker system for the rat genome based on the PCR amplification of interspersed repetitive sequences (IRS). Overall, 351 IRS markers were mapped within the rat genome. The IRS marker panel consists of 210 nonpolymorphic and 141 polymorphic markers that were screened for presence/absence polymorphism patterns in 38 different rat strains and substrains that are commonly used in biomedical research. The IRS marker panel was demonstrated to be useful for rapid genome screening in experimental rat crosses and high-throughput characterization of large-insert genomic library clones. Information on corresponding YAC clones is made available for this IRS marker set distributed over the whole rat genome. The two existing rat radiation hybrid maps were integrated by placing the IRS markers in both maps. The genetic and physical mapping data presented provide substantial information for ongoing positional cloning projects in the rat. (C) 2000 Academic ...
The genetic identification consists to establish the unique and unforgeable DNA fingerprint of a dog, by analysing its DNA.. The DNA fingerprint is made of 22 genetic markers : 21 markers and 1 marker for gender. The genetic markers are coded in letters. The markers combinaison is different from a dog to another , even if they are related ( except true twins).. During parentage verifiation, ANTAGENE compares the DNA fingerprint of the father, the mother and the puppy. The compatible DNA fingerprints betwwen the puppy and the declared parents certify the lineage and brings a DNA certification of the parentage.. The markers panel used by ANTAGENE is following the ISAG 2006 norm.. The ISAG 2006 norm is recognised and validated at the international level by the International Society of Animal Genetics (ISAG). The ISAG 2006 norm is recognised by the FCI (Fédération Cynologique Internationale) and used by almost all Laboratories in Europe.. ANTAGENE is a member of ISAG and scored 100% in the ...
Purpose: BHLHB4 is a transcription factor essential to the maturation of rod bipolar cells (RBs). Adult Bhlhb4-/- mice lack RBs; whilst born in normal numbers, RBs die from postnatal day 8 (PN8) in Bhlhb4-/- retina, suggesting BHLHB4 is required for RB survival. Here we compare the transcriptomes of developing and adult Bhlhb4-/- retina to wildtype (WT) in order to identify novel genetic markers of RBs that may also be important for RB development and/or function.. Methods: Bhlhb4-/- and WT retinal transcriptomes were compared using gene expression microarrays in adult mice (Affymetrix, n=4) and by RNAseq in PN7 mice (n=6): a time that immediately predates significant differences in RB numbers between Bhlhb4-/- and WT retina. Candidate genes were investigated for co-expression with known RB-specific markers in mature RBs using immunofluorescence (IF) and evaluated for differential expression in developing Bhlhb4-/- RBs compared to WT at PN7 with rtPCR and IF.. Results: In adult mice, 97 genes ...
It can be described as some sort of variation present can arise due to mutation or alteration in the genomic loci that can be observed. A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change (SNP), or a long one, like microsatellites. Some commonly used types of genetic markers are RFLP, VNTR, Microsatellite Polymorphism, SNP, STR ...
Interpretive Summary: Microsatellite markers form the scaffolding for the construction of the bovine genetic maps and the mapping of genes influencing economically important traits. They have been used to study the divergence, evolution, and domestication of the bovids and genetic differences across and within breeds. Two bloodlines of Romosinuano cattle exist in the U.S.A. today; one from Costa Rica developed by upgrading (COR) and the other, purebred, from Colombia (COL). Because the bloodlines cannot be distinguished by physical appearance, we attempted to find out if genetic markers could be used to: (1) determine the genetic variation between the two bloodlines and (2) whether an individuals bloodline of origin could be determined based on genetic markers. The discernment of bloodline of origin for individual animals has not yet been accomplished in beef cattle. Using 50 public microsatellite markers, we found that allele frequencies among the shared alleles and alleles unique to either ...
Upon returning from the funeral service for his 26-year-old granddaughter, Samantha Louise Thomas, Ucluelet resident Mike Dickie earnestly wants to share this message with his community:. For everybody taking drugs recreationally, be very careful. Not only does it affect the person thats taking them, but its devastating for friends and family.. His granddaughter, who was working and going to school in Vancouver, passed away on Jan. 13, 2018 after overdosing on a fatal pill. A toxicology report would later confirm she had ingested a mixture of cocaine, morphine, and fentanyl.. As far as I know, she was going to a party and somebody gave her a pill. She got into a taxi and died. She was visiting her mom, he said. [Samantha] was so loved. She didnt have an enemy in the world and she never said a bad thing about anybody. Thats all I can say. She was so loved.. Dickie remembers taking his granddaughter fishing in his rowboat and hanging out at local coffee shops when she came to visit the ...
The project aims to develop a novel strategy to improve longevity and maternal traits in a pig breeding program. We will evaluate the use of genetic markers on crossbred animals to strength pig breeding. A method called genomic selection (GS) will be used, which utilizes DNA-markers for the genetic …. Läs mer ...
VANCOUVER, B.C. AND LOS ANGELES - An upcoming feature-length documentary, Mixed Match, explores the unique challenges faced by multiethnic patients with deadly blood diseases when searching for bone marrow donors.. Mixed Match, inspired by the work of L.A.-based outreach group Mixed Marrow, explains how race and ethnicity play a critical role in finding a marrow match for patients suffering from fatal blood diseases.. In order for a marrow or stem cell match to occur between a patient and donor, genetic markers on the cells must align. Because many of these markers are specific to certain ethnic groups, multiracial people often carry markers in uncommon combinations.. To put this in perspective, if a patient diagnosed with leukemia has a mixed Egyptian, Japanese and Russian background, chances are high that only a person with a similar ethnic blend could be a possible donor. For mixed patients, mono-racial parents and relatives will not likely be a genetic match-even siblings hold only a 1 ...
Unique Jan Brouwer Genetic Marker Found: Results from extending the Y-DNA test to 67 markers in some members of the Jan Brouwer descendants has revealed that we have a marker value that is so rare that it is specific to identifying our own family branch within the larger haplogroup I2b1c. A very rare DYS565 Allele value of 7 repeats has been found in the Jan Brouwer descendants. This value defines a unique family branch within the major haplogroup I2b1c; a mutation that likely occurred in an ancestor living in the Belgium / Netherlands / Germany region 400 to 700 years before the present. If two people share the allele value on this marker and are similar enough across the rest of the markers to share a common ancestor in a genealogical time frame, then they belong to the same family branch and everyone without the rare allele does not. - Richard Brewer. ...
The analysis of genetic marker data is increasingly being conducted in the context of the spatial arrangement of strata (e.g. populations) necessitating a more flexible set of analysis tools. GeneticStudio consists of four interacting programs: (i) Geno a spreadsheet-like interface for the analysis of spatially explicit marker-based genetic variation; (ii) Graph software for the analysis of Population Graph and network topologies, (iii) Manteller, a general purpose for matrix analysis program; and (iv) SNPFinder, a program for identifying single nucleotide polymorphisms. The GeneticStudio suite is available as source code as well as binaries for OSX and Windows and is distributed under the GNU General Public License.
TY - JOUR. T1 - DogMap: An international collaboration toward a low-resolution canine genetic marker map. AU - Dolf, G. AU - Batt, R. AU - Baumle, E. AU - Binns, M. AU - Brenig, B. AU - Bull, B. AU - Dunner, S. AU - Fredholm, M. AU - Gaillard, C. AU - Gerlach, J. AU - Giger, U. AU - Goldspink, G. AU - Graphodatsky, AS. AU - Holmes, N. AU - Judd, S. AU - Juneja, K. AU - Kelly, EP. AU - Kent, MG. AU - King, WA. AU - Lingaas, F. AU - Long, SE. AU - Lubas, G. AU - Mariat, D. AU - Marki, U. AU - Matthews, M. AU - Mellersh, C. AU - Mohan, Ram V. AU - Molyneux, K. AU - Morris, B. AU - Niini, T. AU - Panthier, JJ. AU - Pascal, O. AU - Patterson, D. AU - Pihkanen, S. AU - Randi, E. AU - Reimann, N. AU - Rothuizen, J. AU - Sampson, J. AU - Sanchez, A. AU - Sargan, DR. AU - Schelling, C. AU - Schook, LB. AU - Stranzinger, G. AU - Switonski, M. AU - Troyer, D. AU - Van, de Weghe A. AU - Ward OG, null. PY - 1999/1/1. Y1 - 1999/1/1. M3 - Article. VL - 90. SP - 3. EP - 6. JO - Journal of Heredity. JF - Journal ...
Creation of a genetic risk score comprised of multiple genetic markers associated with cardiovascular disease (CVD) was not associated with significant improvement in CVD risk prediction in a study that included more than 19,000 women, according to a study in the Feb. 17 issue of the Journal of the American Medical Association.
The timely characterization and identification of foodborne bacteria for risk assessment purposes is an integral operation in outbreak investigations. recognition of dispersed conserved genomic markers as an excellent control metric to make sure the validity from the analysis. STEC virulence markers had been determined in every isolates examined properly, and solitary colonies were determined within 9 hrs. This technique gets the potential to create high-resolution characterization of STEC isolates, and whole-genome sequence data generated following the GeneSippr analysis could be 53251-94-8 used for isolate identification in place of lengthy biochemical characterization and typing methodologies. Significant advantages of this procedure include ease of adaptation to the detection of any gene marker of interest, as well as to the identification of other foodborne 53251-94-8 pathogens for which genomic markers have been defined. Introduction Traditional techniques for the detection of pathogenic ...
HILDEN, Germany and GERMANTOWN, Maryland, January 10, 2012 /PRNewswire/ -- Licenses diagnostic rights for ALK (anaplastic lymphoma kinase) gene, a promising target for novel class of lung cancer
Genome-wide association studies have identified at least 22 new genetic markers for CHD risk. The current debate around the value of CRP for CHD risk assessment could be considered a warm-up for things to come.
A study carried out by dozens of scientists, and published in Nature Genetics, identified 15 new genetic markers that can increase the risk of breast cancer. Each of these genetic variations, identified through this study and other research, is known to raise a womans risk of breast cancer by a small amount. Its another step towards a better understanding of how genetic variations work to increase the risk of this type of cancer. ...
Molecular phylogenetic is the branch of phylogeny that analyzes hereditary molecular diversity, mainly in DNA sequences, to increase data on an organisms evolutionary relationships. Due to the taxonomic levels of the study, various molecular markers are applied in molecular phylogeny. The selection of molecular instrument is of paramount matter to ensure that a proper level of variation is meliorated to respond the phylogenetic question. In this review, we have been trying to discuss about gene markers used in the plant phylogeny at various taxonomic levels. The current gene markers used in phylogeny include: the ribosomal nuclear genes, low copy nuclear genes and the extra-nuclear genome (mitochondrial and chloroplastic genomes). Conserved regions could be used at higher taxonomic levels in phylogenetics studies and regions with more changes could be applied between closely related taxa. One of the most common sequences for studying the phylogenetic relationships at the generic and infrageneric
Sarah Williams, health information officer at Cancer Research UK, said: This study was carried out in rats, so we cant say whether similar effects could be seen in people. But studies like this can give us hints about whats going on behind the scenes when cancer develops. ...
While most fans would think that the story of House Frey would be over following the vengeance Arya wrought upon them at the end of Season 6/ the beginning of Season 7 for what they did to her own family at the Red Wedding, apparently there is just a little more story to come from the infamous House before Game of Thrones is over.. According to fan-site The Watchers on the Wall, an actress named Danielle Galligan has been cast as a character named Sarra, who fans of George R.R. Martins source books will recall is the name of Walder Freys granddaughter (her name is even dropped in Season 3 of the series as a potential bride for Robb Stark when Walder is trying to get the King of the North to marry into his family). Of course, there is a chance that this Sarra is not the Sarra who is Walder Freys granddaughter, but that would be odd for Thrones to use the name and spelling of a character already mentioned on the show for a brand new character.. So if she is a Frey, does this mean more ...
Well, this is very inneresting!. On Wednesday, a grandmother gave birth to her own granddaughter in Texas! Tracey Thompson welcomed her granddaughter into the world at the Medical Center of Plano, but we promise its not weird!. The story is actually super sweet!. It turns out Traceys daughter, Kelley McKissack, and her husband, Aaron, have been struggling with infertility for quite a while.. Related: Gay Man Wants To Marry His Adopted Son!. After three years of trying to have a baby of their own, three tragic miscarriages, and multiple infertility treatments, the 28-year-olds mother - who had been post-menopause for seven years - offered to carry the child herself.. Doctors gave the 54-year-old a series of treatments that prepared her body for childbearing, and last April she was successfully implanted with one of Kelleys embryos!. Tracey even shared the adorable announcement on Facebook! Ch-ch-check it out (below)! Tags: aaron mckissack, amazing, baby blabber, crazzzzy, family, ...
I have only one more rad treatment left on Monday & I have felt no ill effects of fatigue lately - praise the Lord! Life is Good! My best friends daughter was married last night & it was a beautiful wedding. They are family to us & it was a very heartwarming event. My oldest 2 granddaughters attended the guest book & my next youngest granddaughter was a flower girl. It sure makes you realize how quickly life passes - the bride, her sister (the Maid of Honor) & my 3 girls grew up together taking family trips to the beach, to the lake, & many times celebrating New Years Eve together! It was a blessed event & made me realize how lucky I am to be at the end of chemotherapy & radiation treatments & be able to feel so great & to have had such a wonderful time last night at this sweet wedding!!! No matter what we go through, life is good, & God remains faithful & true ...
Patti, thanks for taking the time to read my tribute to Livie. I have to say even though my heart has been so heavy since the moment we found out about Livies Trisomy 18, God has been there the whole time. God cares about what we care about. Youre right. There will be many that want to see this little miracle who wasnt supposed to make it to the day of her birth, but was instead a gift of joy to us for 14 months, and still is. Thank you for any whispers of prayer you sent up to the Father. He heard them.. ...
Patti, thanks for taking the time to read my tribute to Livie. I have to say even though my heart has been so heavy since the moment we found out about Livies Trisomy 18, God has been there the whole time. God cares about what we care about. Youre right. There will be many that want to see this little miracle who wasnt supposed to make it to the day of her birth, but was instead a gift of joy to us for 14 months, and still is. Thank you for any whispers of prayer you sent up to the Father. He heard them.. ...
TY - JOUR. T1 - Combining genetic markers with an adaptive meristic trait improves performance of mixed-stock analysis in Baltic whitefish. AU - Ozerov, M. AU - Himberg, Mikael. AU - Debes, P. AU - Hägerstrand, Henry. AU - Vasemägi, A.. PY - 2016. Y1 - 2016. U2 - 10.1093/icesjms/fsw122. DO - 10.1093/icesjms/fsw122. M3 - Artikel. VL - 73. SP - 2529. EP - 2538. JO - ICES Journal of Marine Science. JF - ICES Journal of Marine Science. SN - 1054-3139. IS - 10. ER - ...
The Rolling Stones frontman Mick Jagger has had a life full of romances, as youd imagine any iconic rock stars would be. These days, Jagger is with ballerina Melanie Hamrick, with whom he has one child, four-year-old Deveraux Jagger. Deveraux is Micks eighth child; his other kids range from 22 to 50 years old. And in addition to his children, 78-year-old Mick Jagger also has five grandchildren, including Assisi Jackson, who gave him two great-grandkids. To see the youngest descendants of the
For most children, babysitters are just responsible strangers chosen by their parents. However, some children have the pleasure of calling their babysitters family. One story...
Genetic markers[edit]. Genetic markers are commonly used in Drosophila research, for example within balancer chromosomes or P- ... History of use in genetic analysis[edit]. Alfred Sturtevant's Drosophila melanogaster genetic linkage map: This was the first ... Recessive lethal "balancer chromosomes" carrying visible genetic markers can be used to keep stocks of lethal alleles in a ... Classic genetic mutations[edit]. Drosophila genes are traditionally named after the phenotype they cause when mutated. For ...
"New Research Sheds Light on Old Pedigrees". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. ... "Who's Your Momma III: Some Lines Misplaced". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E ... However, modern genetic studies have revealed that there are some cases where the haplotype in the mtDNA of modern ... A basic understanding of these theories can also help the racing public understand a horse's theoretical genetic potential. The ...
"Who's Your Momma II: Some Lines Converge". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. W ... "New Research Sheds Light on Old Pedigrees". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E. ... "Who's Your Momma III: Some Lines Misplaced". Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17. which cites Hill, E ... One genetic study indicates that 95% of all male Thoroughbreds trace their direct male line (via the Y chromosome) to the ...
"Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... "Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... "Genetic Markers. Thoroughbred Heritage. Retrieved 2008-02-17.. which cites Hill, E. W.; et al. (2002). "History and Integrity ... Although the Thoroughbred is primarily bred for racing, the breed is also used for show jumping and combined training because ...
Such genetic markers[which?] suggest the genetic layout of Southern Chinese peoples is quite similar to that of Southeast ... Molecular anthropologists[who?] have used classical genetic markers and mtDNA to analyze the similarities between early Chinese ... Oota, H., Kurosaki, K., Pookajorn, S., Ishida, T., & Ueda, S. (2001). "Genetic study of the Paleolithic and Neolithic Southeast ... early indigenous Australo-Melanesian peoples comprised the first population of Southeast Asia before their genetic integration ...
Anthropology and genetic markers". Hum. Immunol. 62 (10): 1063. doi:10.1016/S0198-8859(01)00350-0. PMID 11600210. Robin McKie ( ... for having found a marker on Chromosome 7 that is common to Black Africans and, among Caucasoid populations, is found only in ... However they used the same methodology (same gene markers) and same data samples like Arnaiz-Villena et al. Other authors ... They stated that "Using results from the analysis of a single marker, particularly one likely to have undergone selection, for ...
Sources Kole, Chittaranjan (2007). "Molecular Markers and Genetic Mapping". Oilseeds. Volume 2 of Genome Mapping and Molecular ... "Genetic Diversity of Jatropha Curcas With SRAP Molecular Markers". Journal of Zhejiang Forestry College. 27 (3): 347-353. ISSN ... "DNA Polymorphisms Amplified by Arbitrary Primers Are Useful as Genetic Markers". Nucleic Acids Research. 18 (22): 6531-6535. ... "Discriminating Ability of Molecular Markers and Morphological Characterization in the Establishment of Genetic Relationships in ...
Genetic maps, markers and polymorphisms; The C. elegans physical map; Gene expression profiles (stage, tissue and cell) from ... Genetic regulatory relationships; Details of intra- and inter-specific sequence homologies (with links to other Model Organism ...
Drewnowski, Adam; Henderson, Susan Ahlstrom; Barratt-Fornell, Anne (2001). "Genetic taste markers and food preferences". Drug ... Subsequent work revealed that the ability to taste PTC was genetic. In the 1960s, Roland Fischer was the first to link the ... Dinehart, M.E.; Hayes, J.E.; Bartoshuk, L.M.; Lanier, S.L.; Duffy, V.B. (2006). "Bitter taste markers explain variability in ... The term originates with experimental psychologist Linda Bartoshuk, who has spent much of her career studying genetic variation ...
Mourant AE (1977). "The genetic markers of the blood". In Harrison GA (ed.). Population Structure and Human Variation. ... Huang CH, Reid ME, Xie SS, Blumenfeld OO (May 1996). "Human red blood cell Wright antigens: a genetic and evolutionary ... Eriksson AW, Lehmann W, Simpson NE (1980). "Genetic Studies on circumpolar populations". In Milan FA (ed.). The Human Biology ... a genetic characteristic of early immigrants to South America". Science. 134 (3485): 1077-8. Bibcode:1961Sci...134.1077L. doi: ...
Falk, Raphael (21 January 2015). "Genetic markers cannot determine Jewish descent". Frontiers in Genetics. 2014, 5: 462: 462. ... Genetic studies on Jews Interfaith marriage in Judaism Who is a Jew? Reviewed by Louis Jacobs, [1] Originally published in ...
Palo JU, Ulmanen I, Lukka M, Ellonen P, Sajantila A (April 2009). "Genetic markers and population history: Finland revisited". ... The majority of genetic diseases reported in Finland are not part of the Finnish disease heritage and their prevalence is not ... The diseases are not restricted to Finns; they are genetic diseases with far wider distribution in the world, but due to ... Some genetic diseases are disproportionately rare in Finns. These include cystic fibrosis and phenylketonuria. In Finland, ...
European Community, Community Research and Development Information Service (CORDIS) (24 February 2016). "Genetic markers signal ... Genetic analysis of wild einkorn wheat suggests that it was first grown in the Karacadag Mountains in southeastern Turkey. ... 4. International Plant Genetic Resources Institute, Rome, Italy. Archived from the original on 4 December 2007. Saltini Antonio ... "Press Release: ICARDA safeguards world heritage of genetic resources during the conflict in Syria". International Center for ...
December 1986). "Biology of the People of Sikkim, India: 1. Studies on the Variability of Genetic Markers". Zeitschrift für ... April 1992). "Genetic structure of the population of Sicily". American Journal of Physical Anthropology. 87 (4): 395-406. doi: ... December 1987). "Genetic variation of five blood group polymorphisms in ten populations of Assam, India". International Journal ... He also did research on the Indian peoples' genetic variability with respect to the country's ethno-social, regional, and ...
"Early genetic markers of Alzheimer's risk identified". BBC News. Retrieved 16 July 2016. AP via The Washington Post "Postal ... University scientists announce in a study published in the journal Neuron that they have identified a number of genetic markers ... www.foxnews.com/politics/2013/12/22/monday-deadline-for-obamacare-is-milestone-and-marker-uncertainty/[permanent dead link] Fox ...
Chen KH, Cann H, Chen TC, Van West B, Cavalli-Sforza L (1985). "Genetic markers of an aboriginal Taiwanese population". Am J ... Genetic studies have also found similarities between the Atayal and other people in the Philippines and Thailand, and to a ... However, genetic analysis suggests that the different peoples may have different ancestral source populations originating in ... Rachel A. Chow; Jose L. Caeiro; Shu-Juo Chen; Ralph L. Garcia-Bertrand; Rene J. Herrera (2005). "Genetic characterization of ...
"Early genetic markers of Alzheimer's risk identified". BBC. 4 April 2013. Retrieved 4 April 2013. Angela Stark (4 April 2013 ... American scientists announce that they have identified a number of genetic markers that are associated with an increased risk ... 21 May Genetic samples from a museum specimen have revealed the pathogen that caused the 19th-century Great Famine of Ireland. ... A new genetic analysis shows that the first rapid population growth of humans occurred in the Paleolithic (60,000-80,000 years ...
"Managing Boar Taint: Focus on Genetic Markers". The Pig Site. 12 August 2007. Archived from the original on 15 April 2015. ... Jump to navigation Jump to search Surgical or chemical action that removes use of testicles ...
... genetic characterization by microsatellite markers. Italian Journal of Animal Science 2: 223-230. Documentary on Pentro Horse ... G. Cicia, E. D'Ercole, D. Marino (2003). Costs and benefits of preserving farm animal genetic resources from extinction: CVM ...
This was demonstrated using highly variable genetic markers. Sperm was also found stored in the spermathecas of queens. Sexual ... However, antibiotic assays and genetic screenings suggest that it is not an endosymbiont such as Wolbachia causing the ... "Cryptic sexual populations account for genetic diversity and ecological success in a widely distributed, asexual fungus-growing ... reproduction was suggested as a mechanism for maintaining the genetic diversity seen in this species. In summary, M. smithii is ...
1967 Genetic markers as tracers in cell culture. Nat Cancer Inst Monogr 26: 167-195 Gartler, SM. 1968 Apparent HeLa cell ... Since the use of genetic markers to characterize and distinguish cell lines at the time was virtually non-existent, ... Cross culture contamination is now a generally accepted risk, and there are many genetic markers available to accurately ... Examining isoenzymes, he typed them for a number of genetic polymorphisms, including the X linked G6PD variant. The cell lines ...
"Genetic markers for testosterone, estrogen level regulation identified". ScienceDaily.. ...
Holzman, Philip S. (1992). "Behavioral markers of schizophrenia useful for genetic studies". Journal of Psychiatric Research. ... was an investigator of schizophrenia and one of the first to engage in the scientific study of the genetic constituents of its ...
"What is a Genetic Marker?". warwick.ac.uk. Retrieved 2020-05-16. "Genotype versus phenotype". evolution.berkeley.edu. Retrieved ... These markers are analysed by forensic scientists when identifying an unknown body. DNA markers are either a genotype or a ... DNA markers are used to identify specific DNA characteristics that allow for the distinction between different individuals. ... Since then, the method of DNA typing in forensic science has advanced and many techniques to identify microRNA markers in ...
"OCD: New Genetic Marker Reported". 2014-06-07. Retrieved 2015-08-16. Cancer Genome Atlas Network, Koboldt DC, Fulton RS, ...
Brett Lee Shelton; J.D. and Jonathan Marks (2008). "Genetic Markers Not a Valid Test of Native Identity". Counsel for ... "Tribal Enrollment and Genetic Testing - Genetics". genetics.ncai.org. ScienceDaily (2008). "Genetic Ancestral Testing Cannot ... Though DNA testing for ancestry is limited more recent genetic testing research of 2015, have found that varied ancestries show ... Many researchers have published articles that caution that genetic ancestry DNA testing has limitations and should not be ...
Appel J, Friedman JH (January 2004). "Genetic markers and the majority's right not to know". Mov. Disord. 19 (1): 113-4. doi: ... The direct detection of the genetic mutation responsible for MJD has been available since 1995. Genetic testing looks at the ... The symptoms are caused by a genetic mutation that results in an expansion of abnormal "CAG" trinucleotide repeats in the ATXN3 ... Journal of Genetic Counseling. 15 (5): 375-391. doi:10.1007/s10897-006-9033-8. hdl:10316/8027. PMID 17004133. S2CID 23191007. ...
Szathmáry (1981). "Genetic markers in Siberian and northern North American populations". Yearbook of Physical Anthropology. 24 ... the problem of first origins and genetic relations". The First Americans: Origins, Affinities, and Adaptations. Szathmáry, ...
O. A. Ryder et al, ibid Bowling, Ann T.; Ryder, Oliver A. (1987). "Genetic studies of blood markers in Przewalski's horse" (PDF ... As a result of such efforts, the extant herd has retained a far greater genetic diversity than its genetic bottleneck made ... Genetic diversity received a much needed boost from this new source, with the spread of her bloodline through the inbred ... His ideas led to the creation of the Frozen Zoo as a genetic library. Once the foal matures, he will be relocated to the San ...
Jump to navigation Jump to search This article has multiple issues. Please help improve it or discuss these issues on the talk ... Then, they could reliably identify fetal DNA, which would in turn allow them to diagnose certain fetal genetic conditions such ... So they wanted to focus on genetic fragments containing paternally inherited sequences the mother did not share, but had ...
Genetic analysis indicates that there has been an unbroken genetic continuity[clarification needed] of the inhabitants over the ... Jump to navigation Jump to search Major river in Central and Eastern Europe ...
Main article: Genetic causes of type 2 diabetes. Most cases of diabetes involve many genes, with each being a small contributor ... Vitamin D supplementation to people with type 2 diabetes may improve markers of insulin resistance and HbA1c.[119] ... The development of type 2 diabetes is caused by a combination of lifestyle and genetic factors.[25][28] While some of these ... increases the risk of developing diabetes by 1.5 times and is the greatest risk of the common genetic variants.[13] Most of the ...
Ash fungus genetic code unravelled - BBC News *^ a b c "Chalara dieback of ash (Chalara fraxinea)". Forestry Commission. ... Jump to navigation Jump to search Hymenoscyphus fraxineus Scientific classification Kingdom: Fungi ... A Danish study found that substantial genetic variation between ash trees affected their level of susceptibility.[24] However, ... Gross, A.; Grünig, C. R.; Queloz, V.; Holdenrieder, O. (2012). "A molecular toolkit for population genetic investigations of ...
While schizophrenia is widely believed to be multifactorially genetic by biopsychiatrists, no characteristic genetic markers ... The method makes use of a genetic map of the typed markers, and, like analysis of variance, assumes the presence of a single ... Third, when the markers are widely spaced, the QTL may be quite far from all markers, and so the power for QTL detection will ... The choice of marker covariates has not been solved, however. Not surprisingly, the appropriate markers are those closest to ...
A genetic diversity study of endangered Psiadia species endemic from Mauritius Island using PCR markers». Biochemical ...
Jump to navigation Jump to search Marsh Arabs. Maʻdān معدان. Marsh Arab girl from Al Kurhra, Iraq. ... In search of the genetic footprints of Sumerians: a survey of Y-chromosome and mtDNA variation in the Marsh Arabs of Iraq - - ... Many scholars have proposed historical and genetic links between the Marsh Arabs and the ancient Sumerians based on shared ...
The Gotland rabbit has therefore managed to retain a large genetic diversity in terms of shape and colour, at the same time ... Jump to navigation Jump to search Gotland rabbit. The Gotland rabbit is a Swedish variety of rabbit of medium size that comes ... The Gotland rabbit is considered a hardy variety that is rarely affected by disease or genetic defects.[4] ... maintaining good health and few known genetic illnesses.[2] As show breeds gained popularity, the farm rabbits became rarer ...
"UGT1A1 Genetic Polymorphisms, Endogenous Estrogen Exposure, Soy Food Intake, and Endometrial Cancer Risk". Vanderbilt ...
Genetic information can vary up to 10% between strains.[15] Transformation[edit]. Natural bacterial transformation involves the ... Jump to navigation Jump to search Streptococcus pneumoniae S. pneumoniae in spinal fluid. FA stain (digitally colored). ... S. pneumoniae played a central role in demonstrating that genetic material consists of DNA. In 1928, Frederick Griffith ...
Many genetic principles were discovered or confirmed in this species. It was used by Punnett in early studies of genetic ... Jump to navigation Jump to search Species of flowering plant in the pea and bean family Fabaceae ... It is highly suitable as a genetic subject because of its ability to self-pollinate and its easily observed Mendelian traits ...
CDG syndromes are genetic disorders of the glycosylation pathway. They are labelled "Type I" if the defective gene is for an ... Jump to navigation Jump to search STT3. Structure of yeast OST [1] ...
Jump to navigation Jump to search Organelle. Details. Latin. organella. Identifiers. Code. Padron:TerminologiaHistologica. ...
Jump to navigation Jump to search Paleo-Indians hunting a Glyptodon. Glyptodons were hunted to extinction within two millennia ... Archaeological and genetic data suggest that the source populations of Paleolithic humans survived in sparsely wooded areas and ... According to current archaeological and genetic models, there were at least two notable expansion events subsequent to peopling ...
Jump to navigation Jump to search This article is about a skin disease common during adolescence. For other acneiform skin ... Acne can be a feature of rare genetic disorders such as Apert's syndrome.[15] Severe acne may be associated with XYY syndrome.[ ...
Jump to navigation Jump to search For other uses, see Barnacle (disambiguation). ... Harley, C. D. G.; Pankey, M. S.; Wares, J. P.; Grosberg, R. K.; Wonham, M. J. (December 2006). "Color Polymorphism and Genetic ... To facilitate genetic transfer between isolated individuals, barnacles have extraordinarily long penises⁠. Barnacles probably ...
... he discovered genetic markers that could confirm donor matches. The first physician to perform a successful human bone marrow ... Jump to navigation Jump to search "Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, ... Δ32 homozygous individual with two genetic copies of a rare variant of a cell surface receptor. This genetic trait confers ... In addition, a genetic mismatch as small as a single DNA base pair is significant so perfect matches require knowledge of the ...
... we need massive amounts of genetic sequencing. Not just for new cases, but we need to go back and sequence old cases - from ... Jump to navigation Jump to search The Wikipedia Reference Desk covering the topic of science.. Science #eee #f5f5f5 #eee #aaa # ...
In cultured mammalian cells, such as the Chinese hamster ovary cell line, a number of genetic loci are present in a functional ... Jump to navigation Jump to search Homozygous and heterozygous. Zygosity (/zaɪˈɡɒsɪti/) is the degree of similarity of the ... As discussed above, "zygosity" can be used in the context of a specific genetic locus (example[5]). In addition, the word " ... "zygosity" may also be used to describe the genetic similarity or dissimilarity of twins.[6] Identical twins are monozygotic, ...
Fig#1 shows how TipN interact with two other polar proteins : the flagellar marker PodJ , and the stalk marker DivJ. [25] ... The genetic network logic responds to signals received from the environment and from internal cell status sensors to adapt the ... The genetic basis of the phenotypic differences between the two strains results from coding, regulatory, and insertion/deletion ... The central feature of the cell cycle regulation is a cyclical genetic circuit-a cell cycle engine-that is centered around the ...
Galun, Esra, 1927- (2007). Plant patterning : structural and molecular genetic aspects. Singapore: World Scientific. ISBN 981- ... Jump to navigation Jump to search Rastoči apikalni meristem pri pasijonki (Passiflora) ...
Jump to navigation Jump to search Transmission electron micrograph of a mesenchymal stem cell displaying typical ... before any genetic or morphological criteria were put in place for bone marrow or connective tissues. Osteoprogenitor cells can ... Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the ...
Jump to navigation Jump to search The science and practice of the diagnosis, treatment, and prevention of disease ... as the causative genes of most monogenic genetic disorders have now been identified, and the development of techniques in ... transcription and translation of the genetic material. ...
Agrobacterium-mediated genetic engineering techniques were developed in the late 1980s that could successfully transfer genetic ... Jump to: navigation, search Plant physiologist Athanasios Theologis with tomatoes that contain the bioengineered ACC synthase ... A genetically modified tomato, or transgenic tomato, is a tomato that has had its genes modified, using genetic engineering. ... Tomato as a model system: I. Genetic and physical mapping of jointless". MGG Molecular & General Genetics. 242 (6). doi:10.1007 ...
Jump to navigation Jump to search Height of a human which is below typical ... Genetic skeletal dysplasias also known as osteochondrodysplasia usually manifest in short-limbed disproportionate short stature ... The deficiency may be genetic. Among children without growth hormone deficiency, short stature may be caused by Turner syndrome ... On the other hand, most genetic skeletal dysplasias are known for short stature that may be proportionate or disproportionate. ...
Jump to: navigation, search Interactive Specialization is a theory of brain development proposed by the British cognitive ... Development is not a simple question of a brain being built according to a pre-specified genetic blueprint - rather, the ...
Jump to navigation Jump to search The tendency for maximum complexity to increase over time, though without any overall ...
Jump to navigation Jump to search Infectious disease caused by Borrelia bacteria, spread by ticks ... Polymerase chain reaction (PCR) tests for Lyme disease have also been developed to detect the genetic material (DNA) of the ... CSF pleocytosis tests revert to normal after infection ends and therefore can be used as objective markers of treatment success ... this is more common after infection by certain Borrelia strains in people with certain genetic and immunologic characteristics. ...
... genetic factors; immunodeficiencies; loss of habitat; changing beekeeping practices; or a combination of factors.[218][219] ... Marker, Laurie; Marnewick, Kelly; Melzheimera, Joerg; Merkle, Johnathan; M'sokab, Jassiel; Msuhac, Maurus; O'Neill, Helen; ...
Jump to navigation Jump to search This article is about the species Lens culinaris. For the meaning of "lentil" in Indian ... Wild Lens species are a significant source of genetic variation for improving the relatively narrow genetic base of this crop. ... Serious genetic improvement for yield has been made, however, the full potential of production and productivity could not yet ... Although lentils have been an important crop for centuries, lentil breeding and genetic research has a relatively short history ...
RAD markers (or Restriction site associated DNA markers). Molecular genetic markers can be divided into two classes a) ... Genetic markers are employed in genealogical DNA testing for genetic genealogy to determine genetic distance between ... Jump to navigation Jump to search Chicks atop a picture of a genetic map of a chicken. The chicken genome has 39 pairs of ... Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a ...
Genetic markers are thus estimators of biological relatedness, and when they are shared by individuals they are interpreted as ... Genetic MarkerA genetic marker is a trait transmitted from parent to child, thus potentially permitting the reconstruction of ... Genetic Marker Encyclopedia of Race and Racism COPYRIGHT 2008 Thomson Gale. Genetic Marker. A genetic marker is a trait ... A common genetic marker is less valuable than a rare one, for the simple reason that a match between two samples is more likely ...
Scientists have identified early genetic markers that can potentially predict who is at an increased risk for developing ... Genetic markers found to predict Alzheimers Published April 05, 2013. Fox News ... Scientists have identified early genetic markers that can potentially predict who is at an increased risk for developing ... After performing a genetic analysis on 1,269 patients, Goate and her team identified genetic mutations in a previously ...
Delles C., Dominiczak A.F. (2010) Redox-Related Genetic Markers of Cardiovascular Diseases. In: Sauer H., Shah A., Laurindo F ... Genetic determinants of response to clopidogrel and cardiovascular events. N Engl J Med 360(4):363-375PubMedCrossRefGoogle ... Rapp JP (2000) Genetic analysis of inherited hypertension in the rat. Physiol Ver 80:135-172Google Scholar ... Tang NP, Wang LS, Yang L, Gu HJ, Sun QM, Cong RH, Zhou B, Zhu HJ, Wang B (2008) Genetic variant in glutathione peroxidase 1 ...
Research locates new genetic markers that may show an elevated risk of developing prostate cancer. This will help to identify ... With these data, they were able to identify 63 new genetic markers in those with prostate cancer - markers that did not appear ... These genetic markers might make it easier to determine the necessity, as well as the rate, of regular prostate cancer ... Genetic markers - also known as single nucleotide polymorphisms (SNPs) - are detected at the DNA level. These are not only ...
DNA analysis of thousands of people with and without pancreatic cancer finds five new genetic risk markers that could be used ... Prostate cancer: Scientists find 63 new genetic markers Research locates new genetic markers that may show an elevated risk ... New study brings to nine the number of genetic markers for pancreatic cancer. This new study, PanScan III, brings to nine the ... "Pancreatic cancer study finds new genetic risk markers." Medical News Today. MediLexicon, Intl., 4 Aug. 2014. Web.. 22 Apr. ...
... has identified specific genetic markers for scoliosis. And its using the knowledge in a DNA-based prognostic test for spinal ... A Salt Lake company, Axial Biotech Inc., has identified specific genetic markers for scoliosis. And its using the knowledge in ... Scoliosis is a genetic disease that occurs when the spine twists and curves sideways. Adolescent idiopathic scoliosis is that ... Researchers at the company are also analyzing data they hope will lead to better understanding of genetic factors that cause ...
... is considered as one of the major tools in genetic improvement of crop plants in this genomics era. This book describes basics ... Genetic mapping and marker assisted selection (MAS) is considered as one of the major tools in genetic improvement of crop ... Genetic diversity Linkage mapping Marker assisted selection Molecular breeding QTL mapping Authors and affiliations. *N. ... To summarize, this book describes technologies for identification of genes of interest through genetic mapping, recaps the ...
In addition to confirming the eight genetic variants that had already been linked to longevity, this study found 17 more to ... Number of genetic markers linked to lifespan triples An international study found 25 genetic variants linked to human longevity ... number-genetic-markers-linked-lifespan-triples/. More in Medicine & Health. * Featured research from NUTRITION 2020 LIVE ONLINE ... Number of genetic markers linked to lifespan triples. University of Connecticut. Journal. Aging. Funder. Medical Research ...
Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. This is the ... largest set of markers of lifespan uncovered to date. ... This is the largest set of lifespan-associated genetic markers ... Researchers uncover 16 genetic markers linked to decreased lifespan. *Download PDF Copy ... Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. This is the ...
... Sergey Zotchev sergey.zotchev at chembio.ntnu.no Tue Aug 29 10:18:17 EST 2000 *Previous ... I would appreciate any information on the available antibiotic resistance markers other than apramycinR, thiostreptonR, ... hygromycinR, linkomycinR, erythromycinR, viomycinR, neomycinR, kanamycinR and streptomycinR, which can be used for genetic ...
He and his colleagues asked whether any genetic markers could indicate the extent of aging in different tissues and among ... Researchers have long searched for molecular markers that track the rate of physical deterioration that accumulates with age. ... Such work has led to a mishmash of markers that have little in common, notes Zahn. ...
Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer. Previously ... characterized mutations in markers at 8q24 are associated with a broader population than previously reported and with much more ... Genetic Marker For Aggressive Prostate Cancer 36 Posted by kdawson on Monday May 21, 2007 @01:28AM. from the like-a-racehorse ... "Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer. Previously ...
These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker ... The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. In phase l, the plan isto ... This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large ... will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic ...
Genetic markers cannot determine Jewish descent. Raphael Falk*. *Department of Genetics, Program for History and Philosophy of ... 4. ^Haplotype, a contraction of the phrase "haploid genotype," is a set of closely linked genetic markers, a combination of DNA ... Citation: Falk R (2015) Genetic markers cannot determine Jewish descent. Front. Genet. 5:462. doi: 10.3389/fgene.2014.00462 ... Still, the tradition of following discrete genetic markers on the one hand, and the development of methods for following a ...
New research suggests that a simple genetic test could be used to identify multiple sclerosis patients at risk of developing ... Scientists discover genetic markers for severe form of multiple sclerosis Findings may open door to precision medicine for ... The genetic markers for high MIF expression are especially prevalent among men, who disproportionately suffer from the more ... Scientists discover genetic markers for severe form of multiple sclerosis. Oregon Health & Science University ...
Predicting genetic predisposition in humans: the promise of whole-genome markers.. de los Campos G1, Gianola D, Allison DB. ... A perhaps overlooked explanation lies in the limitations of the genetic models and statistical techniques commonly used in ... Although genome-wide association studies have identified markers that are associated with various human traits and diseases, ...
An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific ... An international study on genetic markers was published in Nature.com, which is one of the worlds most prestigious scientific ... International study identifies genetic markers for cancer. Study holds tremendous implications for early detection and ...
Genetic relationships of five Indian horse breeds using microsatellite markers - Volume 1 Issue 4 - R. Behl, J. Behl, N. Gupta ... Genetic relationships of five Indian horse breeds using microsatellite markers. * R. Behl (a1), J. Behl (a1), N. Gupta (a1) and ... Horse genetic resources of India: Spiti ponies. NBAGR Publication, National Bureau of Animal Genetic Resources, Karnal, India. ... Genetic data analysis. Sinauer, Sunderland, MA, USA.. Weir, BS and Cockerham, CC 1984. Estimating F-statistics for the analysis ...
... Rosmeri K. Lazzaretti,1 Aline S. Gasparotto,2 ... M.-H. Chang, A. Yesupriya, R. M. Ned, P. W. Mueller, and N. F. Dowling, "Genetic variants associated with fasting blood lipids ... A. Kay, W. März, M. M. Hoffmann et al., "Coronary artery disease and dyslipidemia within Europe: genetic variants in lipid ... ancestry-informative marker (AIM) panel," Human Mutation, vol. 31, no. 2, pp. 184-190, 2010. View at Publisher · View at Google ...
Study On Rabbit Brain Reveals Genetic Markers Of Domestication. January 17, 2021. Texas A&M ... researchers are able to better understand the link between genetic changes and the mechanisms of evolution in rabbits and, at a ...
Genetic Markers for Focal Segmental Glomerulosclerosis. The safety and scientific validity of this study is the responsibility ... We will draw blood for genetic testing. Our purpose is to determine whether particular genetic variants, including those in ... Currently, over thirteen genetic mutations are associated with FSGS. We are interested in expanding our understanding of these ... Genetic and Rare Diseases Information Center resources: Focal Segmental Glomerulosclerosis Glomerulonephritis U.S. FDA ...
N. D. Young, "Constructing a plant genetic linkage map with DNA markers," in DNA-Based Markers in Plants, pp. 39-57, Kluwer ... Molecular Markers and Cotton Genetic Improvement: Current Status and Future Prospects. Waqas Malik,1 Javaria Ashraf,1 Muhammad ... N. Murtaza, "Cotton genetic diversity study by AFLP markers," Electronic Journal of Biotechnology, vol. 9, no. 4, pp. 456-460, ... N. A. Baird, P. D. Etter, T. S. Atwood et al., "Rapid SNP discovery and genetic mapping using sequenced RAD markers," PLoS ONE ...
Genetic traceability of black pig meats using microsatellite markers.. Oh JD1, Song KD1, Seo JH1, Kim DK1, Kim SH1, Seo KS2, ... In total 800 Jeju black pigs and 351 Berkshires were genotyped at thirteen microsatellite (MS) markers. Analyses on the genetic ... In addition, genetic structure analysis revealed the possibility of gene flow from population B to population J. The expected ... To examine the feasibility of such a system, we aim to provide basic genetic information of the two black pig populations and ...
Shares of the clinical-stage biopharma Applied Genetic Technologies Corporation rose by 23% today on a huge surge in volume ... Why Applied Genetic Technologies Corporation Stock Jumped Today. By George Budwell. Published July 02, 2015. Fool.com ... The article Why Applied Genetic Technologies Corporation Stock Jumped Today originally appeared on Fool.com. ... 30 million investment in Applied Genetic shares. If any products make it to the commercial stage, Applied Genetic would also be ...
Consortium to Identify Genetic Markers that Predict Drug-related Serious Adverse Events. September 27, 2007 , by Walter Jessen ... the U.S. Food and Drug Administration (FDA), and academic institutions plans to identify and validate genetic markers that may ... Genetic Test Results Do Not Trigger Increased Use of Health Services. May 21, 2012 , by NIH Newsbot ... People have increasing opportunities to participate in genetic testing that can indicate their range of risk for developing a ...
In total 80 alleles were detected among 28 genotypes with an average of four alleles per locus and an average marker diversity ... Th e objective of this study was to assess genetic diversity and relationships of 23 soybean genotypes representing several ... use of these genotypes in making crosses to develop further breeding cycles can result in an insuffi cient level of genetic ... breeding sources from Southeastern Europe and fi ve plant introductions from Western Europe and Canada using 20 SSR markers. ...
Assessment of genetic diversity in 35Pisum sativumaccessions using microsatellite markers. Can. J. Plant Sci. 92: 1075-1081. ... Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers. ... "Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers," Canadian Journal of Plant Science ... "Assessment of genetic diversity in 35 Pisum sativum accessions using microsatellite markers," Canadian Journal of Plant Science ...
Demonstrating gains or losses of DNA segments ,1 kb, CNVs are the most common type of variations in genetic structure. More ... Germline CN variants (CNVs) have emerged as key determinants in genetic predisposition to breast cancer and other diseases. ... Based largely on single nucleotide polymorphisms (SNPs) in genes, genetic pathways, or whole-genome scans, studies have ...
A new study suggests that a genetic allele commonly associated with Alzheimers also conveys an increased risk of late-life ... An allele is a form of a gene that can be used to predict the genetic likelihood of someones susceptibility -- and APOE ε4 is ... APOE ε4 might be a marker for identifying older persons at risk to develop depression or dementia, which could be important for ...
  • In gene-mapping studies, DNA markers are commonly differences of a single base among individuals in a population (such differences are called single nucleotide polymorphisms, or SNPs). (encyclopedia.com)
  • Genetic markers - also known as single nucleotide polymorphisms (SNPs) - are detected at the DNA level. (medicalnewstoday.com)
  • The markers are single-nucleotide polymorphisms (SNPs or 'snips'), where a single letter variation occurs in a sequence of DNA in the genome. (medicalnewstoday.com)
  • Based largely on single nucleotide polymorphisms (SNPs) in genes, genetic pathways, or whole-genome scans, studies have identified thousands of SNPs that have significant associations with various aspects of breast cancer, the authors continued. (medpagetoday.com)
  • The SNP array, a technology used to examine hundreds of thousands of features within DNA, detects single nucleotide polymorphisms and establishes genetic markers that can be used to understand the entire genome, particularly with respect to disease susceptibility and the likely success of insecticides and other mosquito-targeted interventions. (scienceblog.com)
  • Professor Armand Sánchez and his colleagues from the Department of Animal and Food Sciences, Universitat Autònoma de Barcelona, and scientists from Applied Biosystems have developed a panel of 46 genetic markers that are all single nucleotide polymorphisms (SNPs), which are single sites of variation in the animal's DNA sequence. (thepoultrysite.com)
  • Genetic diversity, including single nucleotide polymorphisms, contributes to both disease susceptibility and variability in drug response. (nih.gov)
  • Although CRC is a disease that is largely influenced by lifestyle and dietary factors ( 4 ), recent studies have suggested that interindividual genetic variations such as single-nucleotide polymorphisms (SNP) may affect risk for CRC ( 5-7 ). (aacrjournals.org)
  • Genetic markers have been used to establish paternity, to identify the origin of a biological sample at a crime scene, to create maps of disease-causing genes, and to link people who have never met one another into new networks of kinship relations. (encyclopedia.com)
  • By demonstrating that domestic animals acquired tolerance toward humans through regulatory changes of certain genes, researchers are able to better understand the link between genetic changes and the mechanisms of evolution in rabbits and, at a larger scale, of plants and animals in general. (scienceblog.com)
  • Third, when we identify families with multiple affected individuals and which lack known genetic mutations affecting FSGS genes, we will pursue positional cloning. (clinicaltrials.gov)
  • Using DNA sequencing technologies, Zhang's team found that tumors with mutated KMT2 genes, a family of proteins, exhibit a feature of genetic instability with numerous mutations in the genome. (genengnews.com)
  • The results, published online in PLoS Genetics, also reveal that some of the genetic markers for this protein are near genes related to liver function, metabolism and type 2 diabetes, demonstrating an important genetic connection between the metabolic and reproductive systems in men and women. (fiercebiotech.com)
  • These markers have revealed that when mosquito populations begin to separate from each other, it is a very complicated process that can involve hundreds of genes. (scienceblog.com)
  • Any allele or gene associated with a specific chromosome and used in genetic research, as in the identification and location of the other genes in a linkage group. (yourdictionary.com)
  • 5 In addition, genetic variations on the CYP450 genes controlling hepatic metabolism of drugs have been well investigated in recent decades. (mja.com.au)
  • This region is the genetic locus for many diseases and contains many genes associated with immune function. (mja.com.au)
  • Indeed, it could be easier and faster to look at molecular markers that are linked to genes involved in parasitization performances, rather than to check for the variation in the corresponding biological traits ( e.g. , fecundity, sex ratio, longevity, or emergence rate) in such a small insect. (genetics.org)
  • Quantitative traits are usually affected by many genes and consequently the benefit from marker-assisted selection is limited by the proportion of the genetic variance explained by the QTL. (genetics.org)
  • Dr. Offit's research team is now confirming that this risk marker is observed in other populations, and is studying possible changes in two genes in the chromosome 6q region. (mskcc.org)
  • performed a case-controlled analysis in 123 patients with such early in-stent thrombosis of 23 genetic variants in 15 different genes. (sciencemag.org)
  • that licenses the use of DNA markers in four genes. (thepigsite.com)
  • That marker is an increased number of copies of two genes ( plasmepsin II and plasmepsin III ) in those parasites that resist piperaquine. (nih.gov)
  • A research team at the University of Turku discovered a link between the interplay of certain simultaneously occurring genetic changes in the HOXB13 and CIP2A genes, aggressiveness of prostate cancer, high risk of developing the disease, and poorer survival rates of patients. (utu.fi)
  • A set of SSR markers was developed for use in the construction of a genetic map to identify genes involved in controlling genomic restructuring in flax ( Linum usitatissimum L.). SSR sequences were isolated from the flax genome using a modified fast isolation by amplified fragment length polymorphism of sequences containing repeats (FIASCO) procedure. (dovepress.com)
  • Here, we show that several aging related genes may serve as the genetic risk factors for cervical and esophagus cancers. (frontiersin.org)
  • The determination of genetic features of centenarians and genetic status of key genes involved in the pathogenesis of age-related pathologies represent the main approaches to define the key components of active aging and longevity. (frontiersin.org)
  • Genetic polymorphisms in pre-miRNA genes may influence the biogenesis and functions of their host miRNAs. (aacrjournals.org)
  • Our data suggest that genetic polymorphisms in pre-miRNA genes may impact CRC prognosis especially in patients receiving chemotherapy, a finding that warrants further independent validation. (aacrjournals.org)
  • Scientists have found certain variations, or "markers" in human genes that they call Native American markers because they believe all "original" Native Americans had these genetic traits. (councilforresponsiblegenetics.org)
  • 9 Are Genes Good Markers of Biological Traits? (nap.edu)
  • The genetic relationships of five Indian horse breeds, namely Marwari, Spiti, Bhutia, Manipuri and Zanskari were studied using microsatellite markers. (cambridge.org)
  • Genetic traceability of black pig meats using microsatellite markers. (nih.gov)
  • Regions of DNA variation are commonly used for identification purposes, such as in human paternity tests and genetic fingerprinting, but these methods have traditionally relied on larger areas of polymorphism in the DNA sequence known as microsatellite markers. (thepoultrysite.com)
  • With the aid of genetic markers, researchers were able to provide conclusive evidence that the cancerous tumor cell evolved into a transmissible parasite. (wikipedia.org)
  • Researchers from Washington University School of Medicine in St. Louis have identified genetic mutations that can influence the accumulation of Tau proteins, according to Medical Daily. (foxnews.com)
  • The researchers say that there are between 500 and 1,000 genetic markers that could be linked with prostate cancer. (medicalnewstoday.com)
  • As well as investigating which genetic variants are most likely to predict increased risk (work that Schumacher and colleagues are currently focused on), researchers are also looking at genetic changes in men of different races, including African Americans and those of Asian descent. (medicalnewstoday.com)
  • Dr. Wolpin says as well as helping to develop a screening test for pancreatic cancer, another reason the discovery of the markers is important is that it will help researchers looking for molecular explanations of why some people are more susceptible to pancreatic cancer. (medicalnewstoday.com)
  • Researchers at the company are also analyzing data they hope will lead to better understanding of genetic factors that cause the disease. (deseretnews.com)
  • In a study published in the [date] issue of The New England Journal of Medicine , the researchers report that, based on the presence or absence of each marker, 95 percent of gliomas fall into one of five distinct groups, which vary in terms of median survival times and other characteristics. (eurekalert.org)
  • Researchers found a genetic risk score combining the top 10 variants was statistically associated with parents being centenarians. (eurekalert.org)
  • Researchers have identified 16 genetic markers associated with a decreased lifespan, including 14 new to science. (news-medical.net)
  • Researchers have long searched for molecular markers that track the rate of physical deterioration that accumulates with age. (sciencenews.org)
  • Northwestern University researchers have found a genetic marker associated with aggressive forms of prostate cancer . (slashdot.org)
  • Researchers believe that environmental factors may interact with genetic mutations to cause FSGS, at least in some patients. (clinicaltrials.gov)
  • University of Chicago researchers said they have identified a genetic marker that will help identify children most likely to develop asthma after they catch a cold. (sun-sentinel.com)
  • The researchers found that 90 percent of children under age 3 who wheezed after catching a cold and had the genetic marker, which is a DNA sequence associated with a particular gene, developed asthma by the time they turned 6. (sun-sentinel.com)
  • Those children who had two copies of the genetic marker were almost four times as likely to develop asthma as children who did not wheeze when they caught a cold and do not have the genetic marker, the researchers said. (sun-sentinel.com)
  • Researchers at the Wake Forest School of Medicine, part of Wake Forest Baptist Health, say they have identified a set of new genetic biomarkers that could potentially lead to new personalized treatments for lung cancer. (genengnews.com)
  • An international project involving Canadian scientists has identified scores of new genetic markers associated with the risk of breast cancer, a discovery that researchers believe will allow them to more precisely identify who is most at risk. (theglobeandmail.com)
  • We have developed a set of 400,000 markers with which we can study the genetics of the malaria vector mosquito Anopheles gambiae ," said Muskavitch, the DeLuca Professor of Biology at Boston College, who co-authored the paper with an international team of researchers. (scienceblog.com)
  • Researchers have linked genetic markers on eight chromosomes in the tissue surrounding breast tumors to the grade of the cancer and the spread of the disease to the lymph nodes. (emaxhealth.com)
  • In their work, the researchers tested the hypothesis that genetic alterations in stroma, or tissue surrounding breast tumors, significantly altered tumor behavior, as reflected in clinicopathological features at the time of diagnosis. (emaxhealth.com)
  • The researchers completed a cross-sectional analysis of DNA from the epithelium and stroma of 220 primary sporadic invasive breast cancer tumors to identify genetic alterations. (emaxhealth.com)
  • The researchers found eight significant genetic markers that correlated with variances in clinicopathological features. (emaxhealth.com)
  • WEDNESDAY, March 12 (HealthDay News) -- Certain genetic alterations in tumors and tissue from patients with early-stage lung cancer may identify those at greatest risk for cancer recurrence, say researchers at the Johns Hopkins Kimmel Cancer Center. (bio-medicine.org)
  • Fox Chase Cancer Center researchers have identified a genetic marker that is associated with an earlier onset of prostate cancer in Caucasian men who have a family history of prostate cancer. (biologynews.net)
  • The marker, while associated with drug resistance, likely does not play a functional role in enabling parasites to resist piperaquine, according to the researchers. (nih.gov)
  • The researchers analyzed the PNPLA3 gene, the most important genetic factor for both alcoholic liver disease and nonalcoholic fatty liver disease, according to Dunn, and specifically focused on the rs738409 polymorphism, a variation in a single base pair of DNA in the PNPLA3 gene. (healio.com)
  • K-State researchers part of team that discovers marker for costly porcine reproductive and respiratory syndrome. (farmprogress.com)
  • Rowland and researchers Jack Dekkers from Iowa State University and Joan Lunney from the Agricultural Research Service discovered a genetic marker called a quantitative trait locus, which is associated with porcine reproductive and respiratory syndrome virus susceptibility. (farmprogress.com)
  • Researchers found that only four of nearly 630 patients without either marker died as a result of papillary thyroid cancer. (southlakeoncology.com)
  • The researchers looked in rats' brains for the genetic instructions needed to make a key "pleasure receptor", called D2, that allows brain cells to receive signals sent by the brain chemical dopamine - or cocaine. (technologynetworks.com)
  • Now, a new study by based researchers at the University of Cambridge and the Pirbright Institute in the UK has identified key genetic changes in SARS-CoV-2 that may be responsible for the virus's jump from bats to humans. (news-medical.net)
  • This chapter describes which gene polymorphisms and serological markers may be used to distinguish between ulcerative colitis and Crohn's disease in patients with histologically unclassified colitis. (edu.mt)
  • These markers are valuable for pomegranate varietal group identification, but they show limited levels of detection of inter-varietal and intra-varietal polymorphisms on account of their environmental plasticity. (scielo.cl)
  • After evaluation, the genetic structure of this collection (200 accessions) was compared with that of landraces from the states of Oaxaca, Chiapas and Veracruz (10 genotypes from each), as well as a further 10 cultivars, by means of four amplified fragment length polymorphisms (AFLP) +3/+3 primer combinations and seven simple sequence repeats (SSR) loci, in order to define genetic diversity, variability and mutual relationships. (scielo.br)
  • However, investigation of genetic causes of idiosyncratic drug reactions has the potential to be more worthwhile than the investigation of effects like myopathy with statins in terms of the predictive value of the polymorphisms. (mja.com.au)
  • Haplotypes of IL-4 receptor and CD14 genetic polymorphisms are markers of susceptibility for diisocyanate asthma. (cdc.gov)
  • Genetic markers are employed in genealogical DNA testing for genetic genealogy to determine genetic distance between individuals or populations. (wikipedia.org)
  • Because type O blood is the most ubiquitous blood type among all human populations, two people who are not close relatives are nevertheless very likely to exhibit this genetic marker. (encyclopedia.com)
  • To examine the feasibility of such a system, we aim to provide basic genetic information of the two black pig populations and assess the possibility of genetically distinguishing between the two breeds. (nih.gov)
  • Analyses on the genetic diversity of the two populations were carried out in the programs MS toolkit and FSTAT. (nih.gov)
  • In addition, genetic structure analysis revealed the possibility of gene flow from population B to population J. The expected probability of identify value of the 13 MS markers was 9.87×10(-14) in population J, 3.17×10(-9) in population B, and 1.03×10(-12) in the two populations. (nih.gov)
  • These results support a model in which genetic changes in both stroma and epithelial compartments occur during (the formation of tumors) and progression is co-determined by local interaction between these cell populations within the primary tumor," the JAMA study reports. (emaxhealth.com)
  • Individual genetic markers are then used to estimate the demographic parameters of these populations. (innovations-report.com)
  • 2005). Nevertheless, domestication has caused genetic drift in populations planted in the primary domestication centers (Gepts, 2004). (scielo.br)
  • Three linkage maps of the genome of the microhymenopteran Trichogramma brassicae were constructed from the analysis of segregation of random amplified polymorphic DNA markers in three F 2 populations. (genetics.org)
  • These populations were composed of the haploid male progeny of several virgin F 1 females, which resulted from the breeding of four parental lines that were nearly fixed for different random amplified polymorphic DNA markers and that were polymorphic for longevity and fecundity characters. (genetics.org)
  • As the order of markers common to the three mapping populations was found to be well conserved, a composite linkage map was constructed. (genetics.org)
  • Consequently, population stratification has become one of the most important confounding factors in population-based genetic association studies, especially in Latino populations. (scirp.org)
  • 2010) Genetic Make up and Structure of Colombian Populations by Means of Uniparental and Biparental DNA Markers. (scirp.org)
  • In order to detect the genetic relationship of different Cotoneaster schantungensis natural populations, 16 samples were selected for genetic diversity analysis based on SRAP markers. (scirp.org)
  • The genetic differentiation coefficient in populations (Gst) was 0.0788, gene flow Nm was 5.8467, indicating that there was 7.88% of the variation among populations and 92.12% of the variance within populations and the variation within populations was relatively high. (scirp.org)
  • These results indicate that C. schantungensis has high genetic diversity and low differentiation among populations. (scirp.org)
  • Cole, C.T. and Kuchengeuther, M.A. (2001) Molecular Markers Reveal Little Genetic Differentiation among Aconitum noveboracense and A. columbianum (Ranunculaceae) Populations. (scirp.org)
  • Su, H.L. and Tang, S.Q. (2004) Genetic Diversity of the Endangered Plant Abiesziyuanensis in Two Populations. (scirp.org)
  • The objective of this study was to estimate genetic variability among and within maize and teosinte populations ( Zea mays mexicana). (scielo.br)
  • Two sweet maize populations (BR400 and BR402), two common maize populations (Suwan and Pampa) and one teosinte population were analyzed using microsatellites markers. (scielo.br)
  • Results indicated that 64,5% of the variation was detected within the populations, suggesting the possibility of obtaining genetic progress by selection within each population. (scielo.br)
  • populations from the species O. ficus-indica , O. elata , O. dillenii and O. robusta using nuclear microsatellite (nuSSR) markers. (mdpi.com)
  • The estimated Dice coefficient among populations varied from 0.26 to 1.0, indicating high interspecific genetic diversity but low genetic diversity at the intraspecific level. (mdpi.com)
  • The results revealed a low level of genetic diversity among the Portuguese populations of O. ficus-indica . (mdpi.com)
  • Are there genetic markers for alcoholism in African populations? (aphrc.org)
  • This study was initiated to assess the levels of genetic diversity and differentiation in the remaining populations of Phyllostegia stachyoides and Melicope zahlbruckneri in Hawai`i Volcanoes National Park and determine the extent of gene flow to identify genetically distinct individuals or groups for conservation purposes. (usgs.gov)
  • Analysis of molecular variance of P. stachyoides showed that 4% of the observed genetic differentiation occurred between populations in different k ī puka and 96% when individuals were pooled from all k ī puka. (usgs.gov)
  • Bayesian and multivariate analyses both classified the P. stachyoides and M. zahlbruckneri populations into genetic groups with considerable sub-structuring detected in the P. stachyoides population. (usgs.gov)
  • The proportion of genetic differentiation among populations explained by geographical distance was estimated by Mantel tests. (usgs.gov)
  • No spatial correlation was found between genetic and geographic distances in both populations. (usgs.gov)
  • The results of this study highlight the utility of a multi-allelic DNA-based marker in screening a large number of polymorphic loci in small and closely related endangered populations and revealed the presence of genetically unique groups of individuals in both M. zahlbruckneri and P. stachyoides populations. (usgs.gov)
  • Although genome-wide association studies have identified markers that are associated with various human traits and diseases, our ability to predict such phenotypes remains limited. (nih.gov)
  • Construction of a genetic linkage map and QTL analysis of fiber-related traits in upland cotton ( Gossypium hirsutum L.)," Euphytica , vol. 144, no. 1-2, pp. 91-99, 2005. (hindawi.com)
  • Genomic variation affecting traits of adaptive significance can be considered as the prime diversity to optimize in genetic resources collections. (wur.nl)
  • Crosses between teosinte and maize occur freely and teosinte serves as genetic source of agronomic traits for introduction in maize. (scielo.br)
  • The SNPlex platform is ideal for analyzing larger numbers of markers, and additional markers can be easily added to the panel as required, such as when breeders wish to identify specific genetic traits. (thepoultrysite.com)
  • The tests could also be useful for animal breeders and farmers who wish to identify genetic markers associated with particularly desirable traits in terms of meat quality and flavor, and could be adapted for identification and traceability in other animal species, such as sheep, cows and poultry. (thepoultrysite.com)
  • The candidate gene approach has been widely used to search for the genetic basis of pharmacogenomic traits. (nih.gov)
  • By focusing on non-model plant organisms and by using transcriptomics and/or genomics, we seek to develop and characterize genetic markers that are associated to certain traits (e.g. drought resistance). (ait.ac.at)
  • The more that addiction is seen as having biological roots and origins in genetic traits that are inherited through families or amplified by drug taking, the better treatment options and public policy around drugs and drug users can be, she hopes. (technologynetworks.com)
  • Raised for dozens of generations in the lab of senior author Huda Akil, Ph.D., at the U-M Molecular and Behavioral Neuroscience Institute under carefully controlled conditions, the two breeds act as a way to study the effects of genetic and inherited traits on addiction-related behaviors. (technologynetworks.com)
  • Even before the development of the science of genetics, however, similarities of the language, skeleton, and teeth were being understood as crude genetic markers. (encyclopedia.com)
  • M. J. Iqbal, O. U. K. Reddy, K. M. El-Zik, and A. E. Pepper, "A genetic bottleneck in the 'evolution under domestication' of upland cotton Gossypium hirsutum L. examined using DNA fingerprinting," Theoretical and Applied Genetics , vol. 103, no. 4, pp. 547-554, 2001. (hindawi.com)
  • One of the most important findings in the study is that now we have a genetic marker that helps us identify those children with the highest risk of developing asthma,' said co-senior author Carole Ober, a professor of human genetics at the U. of C. 'In the first three years of life, one-third of children who get sick and wheeze go on to develop asthma. (sun-sentinel.com)
  • Their findings, published in two separate studies in the journals Nature and Nature Genetics on Monday, reveal 72 new genetic variants that predispose women to breast cancer. (theglobeandmail.com)
  • One justification for molecular genetics research on livestock and crop species is the expectation that information at the DNA level will lead to faster genetic gain than that achieved based on phenotypic data only. (genetics.org)
  • Rapid developments in cancer genetics have exposed a knowledge vacuum about genetic testing for susceptibility to cancer. (dtic.mil)
  • By studying the genetics of the tumours, they discovered that instead of one cancer, the tumours have three sub-types featuring distinct genetic abnormalities and leading to different outcomes for patients. (healthcanal.com)
  • With state-of-the-art genotyping technologies we further utilize genetic markers in the frame of breeding and selection processes, for species identification (e.g. via DNA barcoding), population genetics and diversity analyses, for paternity testing, or for the proof of a sample's origin and authenticity. (ait.ac.at)
  • The study authors analyzed genetic and clinical data from 1,087 malignant glioma patients and 11,590 healthy controls from Mayo Clinic, UCSF and The Cancer Genome Atlas, a program of the National Cancer Institute. (eurekalert.org)
  • Predicting genetic predisposition in humans: the promise of whole-genome markers. (nih.gov)
  • Together, the two studies, for which Genome Canada, Génome Québec and the Canadian Institutes of Health Research are among the principle funders, involved analyzing the genetic data of about 275,000 women, including 146,000 who had been diagnosed with breast cancer. (theglobeandmail.com)
  • Each marker is like a genetic signpost along the genome. (scienceblog.com)
  • By using correlations among genetic markers close to one another in the genome, the method can succeed even if the datasets contain no overlapping markers. (pnas.org)
  • Thus, for example, genome-wide association study samples typed with different SNP sets are routinely combined by cross-imputation, in which markers typed only in a subset of samples are probabilistically imputed in each sample, so that all markers can be analyzed in all samples ( 1 ⇓ - 3 ). (pnas.org)
  • In a genetic context, record matching involves the identification of the same individual genome across multiple datasets when unique identifiers, such as participant names, are unavailable. (pnas.org)
  • The completion of the Human Genome Project in 2003 and the development of cost-effective means for scanning large regions of DNA have paved the way for large-scale pharmacogenetic investigations involving many genetic loci. (mja.com.au)
  • A genome of 1000 cM was simulated with a marker spacing of 1 cM. (genetics.org)
  • The study used a genome-wide association design in which the frequencies of hundreds of thousands of genetic variations across the genome are compared between large numbers of cases and unaffected controls. (innovations-report.com)
  • In the first stage, more than 620,000 genetic variations were analyzed in the whole genome of 1,817 women with ovarian cancer and compared to 2,353 women without the disease. (innovations-report.com)
  • The study used a methodology called genome-wide association mapping, which looks at genetic variations across the entire genome that alter the individual building blocks of DNA makeup. (mskcc.org)
  • The four markers made available by Iowa State University precede the current effort to sequence the swine genome, but they are an indication of how this research can be applicable on the farm. (thepigsite.com)
  • Now, by comparing the complete genomes of 297 parasites isolated from Cambodian malaria patients to a reference malaria parasite genome, the team has identified two genetic markers that are strongly associated with the parasites' ability to resist piperaquine. (nih.gov)
  • Eight genetic variants had already been linked to lifespan, mainly variants that are involved in heart disease and dementia. (eurekalert.org)
  • The results confirm that many genetic variants combine to influence human lifespan: no single gene variant has been found to be responsible. (eurekalert.org)
  • In the present study, we are addressing the hypothesis that genetic variation contributes to the pathogenesis of idiopathic FSGS and collapsing glomerulopathy, both idiopathic and HIV associated variants. (clinicaltrials.gov)
  • Germline CN variants (CNVs) have emerged as key determinants in genetic predisposition to breast cancer and other diseases. (medpagetoday.com)
  • Although these genetic variants only explain a small fraction of the sex hormone variability seen between individuals, they could provide insight into the diseases connected to sex hormone regulation. (fiercebiotech.com)
  • The results, published in the journal Aging NY, confirm that many genetic variants - not one - combine to influence human lifespan. (indianexpress.com)
  • Genetic testing in patients with established pulmonary fibrosis is also being conducted to determine if certain genetic variants influence outcomes or capture different disease states. (brighamandwomens.org)
  • While the risk associated with this genetic marker is much lower than that of BRCA genetic mutations for example, this discovery will increase the understanding of the genetic variants that contribute to breast cancer. (mskcc.org)
  • After performing a genetic analysis on 1,269 patients, Goate and her team identified genetic mutations in a previously implicated region, found in the gene TREM2, as putting people at risk for Alzheimer's. (foxnews.com)
  • Previously characterized mutations in markers at 8q24 are associated with a broader population than previously reported and with much more aggressive tumors. (slashdot.org)
  • Currently, over thirteen genetic mutations are associated with FSGS. (clinicaltrials.gov)
  • Their discovery: The tumors have three subtypes--each with particular genetic mutations that give patients different outcomes. (fiercebiotech.com)
  • He says that instead of pinning one's hopes on new genetic markers, efforts would be better spent on providing genetic tests for BRCA1 and BRCA2 mutations to a wider population. (theglobeandmail.com)
  • A recent study has shed light on particular genetic mutations that may signal an elevated morality risk. (southlakeoncology.com)
  • More than 1800 individuals sampled from 105 sites were analyzed with a set of allozyme loci (hopefully representing neutral or nearly neutral markers) and X-linked loci (which are assumed to be under selection). (bioone.org)
  • We show that records can be matched across genotype datasets that have no shared markers based on linkage disequilibrium between loci appearing in different datasets. (pnas.org)
  • Abstract Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. (sbir.gov)
  • Genetic markers have also been used to measure the genomic response to selection in livestock. (wikipedia.org)
  • The invention relates to the screening of tissue samples and genomic regions to discover markers for genetic disorders such as cancer. (google.com)
  • We show that the method can link a dataset similar to those used in genomic studies with another dataset containing markers used for forensics. (pnas.org)
  • The estimated genetic distance confirmed the genomic similarity of maize and teosinte. (scielo.br)
  • The paper, Markers of Survival and Metastatic Potential in Childhood CNS Primitive Neuro-Ectodermal Brain Tumours: an Integrative Genomic Analysis, can be accessed via The Lancet's website. (healthcanal.com)
  • The array features 400,000 SNPs from among the 3 million found in four sequenced strains of Anopheles gambiae , which provides an immensely higher resolution than the 42- and 1,536-marker sets previously available to malaria vector biologists. (scienceblog.com)
  • This task is relatively simple when large numbers of SNPs are shared between marker sets: if records from different datasets match at enough of the shared SNPs, then they can be taken to represent the same individual. (pnas.org)
  • The SNPlex Genotyping System allows the simultaneous genotyping of up to 48 SNPs against a single biological sample, and can be used with genetic analyzers from Applied Biosystems, which set the standard as the most robust line of capillary electrophoresis systems available in the market. (thepoultrysite.com)
  • In addition, emerging evidence has shown that SNPs may be used as surrogate biomarkers of the genetic background of CRC patients to predict therapeutic response and prognosis ( 8-11 ). (aacrjournals.org)
  • Genetic markers have to be easily identifiable, associated with a specific locus , and highly polymorphic , because homozygotes do not provide any information. (wikipedia.org)
  • This will establish the superiority of this marker class and support thework of phase Il which includes isolation of a large number of the markers, more thorough characteriza-tion of their polymorphic content, and application in generation of linkage maps. (sbir.gov)
  • The objective of the present study is to assess genetic diversity in 35 diverse Pisum accessions using 15 polymorphic microsatellites located on different pea chromosomes. (bioone.org)
  • These markers were scored by their polymorphic information content (PIC), ranging from 0.055 (AA206) to 0.660 (AB72) with an average of 0.460, and by their discriminating power (D), which varied from 0.057 (AA206) to 0.679 (AB 72) with an average of 0.475. (bioone.org)
  • Recently, attention has been focused on the use of different molecular markers such as RAPD (randomly amplified polymorphic DNA), SSR (simple sequence repeat), SRAP (sequence-related amplified polymorphism), ISSR (inter-simple sequence repeat) and AFLP (amplified fragment length polymorphism) in different fruit species to determine genetic diversity and relationships among cultivars. (scielo.cl)
  • DNA markers linked to insensitivity were obtained by bulked segregant analysis using random amplified polymorphic DNA (RAPD) markers and the Dutch and Mexican crosses. (apsnet.org)
  • A Salt Lake company, Axial Biotech Inc., has identified specific genetic markers for scoliosis. (deseretnews.com)
  • The test was developed in collaboration with Applied Biosystems, an Applera Corporation business, and uses a number of specific genetic markers to identify individual animals, providing complete meat traceability and ensuring protection for consumers. (thepoultrysite.com)
  • The U.S. Food and Drug Administration today cleared for marketing the Xpert Carba-R Assay, an infection control aid that tests patient specimens to detect specific genetic markers associated with bacteria that are resistant to Carbapenem antibiotics. (fda.gov)
  • The study in question focused in on two specific genetic markers - BRAF V600E and TERT. (southlakeoncology.com)
  • And each group had a separate genetic signature based on variations in the way they expressed the LIN28 and OLIG2 genetic markers. (fiercebiotech.com)
  • They found that each group had its own genetic signature through subtle differences in the way they expressed two genetic markers, LIN28 and OLIG2. (healthcanal.com)
  • Ultimately, the research has identified the two genetic markers LIN28 and OLIG2 as a promising basis for more effective tools for diagnosing and predicting outcomes for young patients with these types of brain tumours. (healthcanal.com)
  • A genetic marker is a gene or DNA sequence with a known location on a chromosome that can be used to identify individuals or species . (wikipedia.org)
  • For many years, gene mapping was limited to identifying organisms by traditional phenotype markers. (wikipedia.org)
  • This prompted the development of gene markers which could identify genetic characteristics that are not readily observable in organisms (such as protein variation). (wikipedia.org)
  • Molecular genetic markers can be divided into two classes a) biochemical markers which detect variation at the gene product level such as changes in proteins and amino acids and b) molecular markers which detect variation at the DNA level such as nucleotide changes: deletion, duplication, inversion and/or insertion. (wikipedia.org)
  • Genetic markers can be used to study the relationship between an inherited disease and its genetic cause (for example, a particular mutation of a gene that results in a defective protein ). (wikipedia.org)
  • This property enables the use of a marker, which can then be used to determine the precise inheritance pattern of the gene that has not yet been exactly localized. (wikipedia.org)
  • Shares of the clinical-stage biopharma Applied Genetic Technologies Corporation rose by 23% today on a huge surge in volume after the company inked a broad research collaboration with biotech giant Biogen to develop multiple gene therapy treatments for rare diseases of the eye. (foxbusiness.com)
  • Regarding Applied Genetic, this tiny biopharma could receive milestone payments in excess of $1 billion, if its gene therapy platform bears fruit. (foxbusiness.com)
  • An allele is a form of a gene that can be used to predict the genetic likelihood of someone's susceptibility -- and APOE ε4 is particularly associated with dementia. (wired.co.uk)
  • It could be concluded that markers that are targeted to specific gene sequences may still behave as anonymous markers if their relationship with the phenotypic variation has not been established. (wur.nl)
  • Ledig, F.T. and Conkle, M.T. (1983) Gene Diversity and Genetic Structure in a Narrow Endemic, Torrey Pine (Pinustorreyana Parry ex Carrière). (scirp.org)
  • Li, G. and Quiros, C.F. (2001) Sequence-Related Amplified Polymorphism (SRAP), a New Marker System Based on a Simple PCR Reaction: Its Application to Mapping and Gene Tagging in Brassica. (scirp.org)
  • The new marker was found on chromosome 9, close to the BNC2 (basonuclin 2) gene that encodes a protein which plays a role in regulation of DNA transcription and is highly expressed in reproductive tissues. (innovations-report.com)
  • The first gene marker is MC4R and it controls growth and leanness. (thepigsite.com)
  • The second gene marker is PRKAG3. (thepigsite.com)
  • The third gene marker is CAST, a gene that affects tenderness and meat quality. (thepigsite.com)
  • The fourth gene marker is HMGA1, which is highly associated with backfat and lean growth. (thepigsite.com)
  • The first marker they identified is a change of one subunit in a gene on the parasite's chromosome 13. (nih.gov)
  • Working on something like SCCOHT seemed an obvious choice as it is a unique genetic disease driven by loss of a single gene, SMARCA4 ," explains Dr. Huang, who is also a member of McGill's Goodman Cancer Research Centre. (mcgill.ca)
  • Especially for the latter, a genetic marker reflects a DNA sequence which is linked to a gene or trait of interest, and can thereby be directly used in marker-assisted selection (MAS). (ait.ac.at)
  • 10 This was the first time a regulatory authority had recognised a genetic predisposition for a hypersensitivity reaction. (mja.com.au)
  • Previous family studies have demonstrated that approximately 50 per cent of the variation in SHBG concentrations in the bloodstream is inherited from parents, suggesting that SHBG levels are under significant genetic control. (fiercebiotech.com)
  • Here, SSR analysis indicated a reduced number of shared haplotypes among accessions, whereas the highest genetic components of AMOVA variation were found within accessions. (scielo.br)
  • Complex genetic patterns found in Cartagena's population emphasize the importance to know the genetic variation in order to diminish the inconsistence for future genetic association studies. (scirp.org)
  • Genetic diversity is a decisive factor of successful response of one specie to human disturbance, and the degree of intra specific genetic variation also has key effect on its potentiality of evolution . (omicsonline.org)
  • Q. H. Xu, X. L. Zhang, and Y. C. Nie, "Genetic diversity evaluation of cultivars ( G. hirsumtum L.) from the Changjiang river valley and Tellow river valley by RAPD markers," Acta Genetica Sinica , vol. 28, no. 7, pp. 683-690, 2001. (hindawi.com)
  • Among them, RAPD has been extensively used in pomegranate because of its simplicity and low cost, but this marker system generates a limited number of polymorphism in pomegranate (Durgac et al. (scielo.cl)
  • While this technique is fast and convenient, the major drawback of RAPD markers is their dominant mode of inheritance. (genetics.org)
  • Torres, E., Iriondo, J.M. and Pérez, C. (2003) Genetic Structure of a Endangered Plant, Antirrhinum microphyllum (Scrophulariaceae ): Allozyme and RAPD Analysis. (scirp.org)
  • Han, C.Y., Sun, W.B. and Gao, L.M. (2004) Analysis of Genetic Diversity of Trigonobalanus doichangensis (Fagaceae) by RAPD. (scirp.org)
  • By studying the linkage relationships between these markers and the insensitivity in each cross by RAPD or restriction fragment length polymorphism analysis, it appeared that the same chromosomal locus conferred insensitivity in the Mexican and Dutch isolates. (apsnet.org)
  • Genetic mapping and marker assisted selection (MAS) is considered as one of the major tools in genetic improvement of crop plants in this genomics era. (springer.com)
  • Scientists have identified early genetic markers that can potentially predict who is at an increased risk for developing Alzheimer's, Medical Daily reported. (foxnews.com)
  • These markers will potentially allow us to predict the course of gliomas more accurately, treat them more effectively and identify more clearly what causes them in the first place. (eurekalert.org)
  • the U.S. Food and Drug Administration (FDA) , and academic institutions plans to identify and validate genetic markers that may help predict which individuals are at risk for serious adverse drug events. (highlighthealth.com)
  • It is rather remarkable that genetic alterations in seven chromosomal regions that predict for poor outcome, such as spread of tumor to the lymph glands and aggressive appearance of the tumor, reside in the stroma," said Dr. Eng. (emaxhealth.com)
  • Genetic Markers May Predict Lung Cancer R... ( DNA evidence in lymph nodes could alt. (bio-medicine.org)
  • CHICAGO - A research team identified genetic markers that predict which patients with hepatitis C and cirrhosis will most likely improve with direct-acting antiviral agent and those who will fail to improve or possibly worsen, according to a presentation at Digestive Disease Week. (healio.com)
  • Genetic ancestry services principally use markers derived from Y chromosome DNA and mitochondrial DNA to establish matches between samples of presumptive relatives. (encyclopedia.com)
  • In this paper, we present results of the first comprehensive study of the introgression of both autosomal and sex-chromosome markers across the central European portion of the hybrid zone between two house mouse subspecies, Mus musculus musculus and M. m. domesticus . (bioone.org)
  • Chromosome segments that contain the same rare marker haplotypes are likely to be identical by descent (IBD) and hence carry the same QTL allele. (genetics.org)
  • Our approach is to estimate the effect on the quantitative trait of small chromosome segments defined by the haplotypes of marker alleles that they carry. (genetics.org)
  • However, a dense marker map defines a very large number of chromosome segments and so there will be many effects to be estimated, probably more than there are phenotypic data points from which to estimate them. (genetics.org)
  • Molecular marker DNA marking Eukaryotic chromosome fine structure Repeated sequence (DNA) Benjamin A. Pierce (2013-12-27). (wikipedia.org)
  • The markers are principally analyzed in two locations in people's genetic material: in their mitochondrial DNA (mtDNA) and on the Y-chromosome. (councilforresponsiblegenetics.org)
  • Y-chromosome and mtDNA markers are the most commonly used genetic markers for the analysis of Native American ancestry. (councilforresponsiblegenetics.org)
  • Genetic markers associated with certain diseases can be used to determine whether an individual is at risk for developing an inherited disease. (yourdictionary.com)
  • Consequently, use of these genotypes in making crosses to develop further breeding cycles can result in an insuffi cient level of genetic variability. (psu.edu)
  • Th e objective of this study was to assess genetic diversity and relationships of 23 soybean genotypes representing several independent breeding sources from Southeastern Europe and fi ve plant introductions from Western Europe and Canada using 20 SSR markers. (psu.edu)
  • In total 80 alleles were detected among 28 genotypes with an average of four alleles per locus and an average marker diversity of 0.585. (psu.edu)
  • In this study, we attempted to characterize 19 promising pomegranate genotypes originating from the Coruh Valley in using fluorescent dye AFLP markers and capillary electrophoresis. (scielo.cl)
  • Therefore, the results showed that molecular characterization is necessary to get reliable relationships among pomegranate genotypes and AFLP markers can be used effectively in pomegranate. (scielo.cl)
  • 11 Genetic mapping involved a comparison of HLA genotypes for 44 patients with Stevens-Johnson syndrome or toxic epidermal necrolysis with those of 101 controls who had taken carbamazepine for at least 3 months without development of any skin reaction, and 93 healthy individuals. (mja.com.au)
  • Although selection based mainly on seed-class has reduced genetic diversity in cultivars developed in several production areas, variety in consumer preference has been of aid in its maintenance (Rosales Serna et a l., 2005). (scielo.br)
  • Evidence of linkage disequilibrium among these markers will be sought between patients with and without FSGS. (clinicaltrials.gov)
  • Due to finite population size ( N e = 100), the marker haplotypes were in linkage disequilibrium with the QTL located between the markers. (genetics.org)
  • This agreement is obviously a much bigger deal for Applied Genetic than Biogen, but it does signal that Biogen is deeply interested in diversifying its clinical pipeline. (foxbusiness.com)
  • The two companies agreed to a rather fluid deal that allows Applied Genetic to opt-in in terms of sharing development costs and profits after the initial clinical data are a known entity. (foxbusiness.com)
  • Applied Genetic will also be responsible for shepherding these experimental products through the clinical trial process, with Biogen playing a supportive role during this process. (foxbusiness.com)
  • To address this problem, the team is embarking on a novel research study involving both the clinical assessment and genetic testing of patients with established pulmonary fibrosis, and then testing their first-degree relatives for genetic risk factors. (brighamandwomens.org)
  • This newly identified genetic marker will not have any immediate clinical implications or impact on current screening guidelines for familial breast cancer," said Dr. Offit. (mskcc.org)
  • Although the predictive accuracy of the genetic-only model (positive likelihood ratio of 2.0) was comparable with that of the clinical-only model (positive likelihood ratio of 2.1), the combination of the two models generated a statistically significant increase in predictive power (positive likelihood ratio of 3.4). (sciencemag.org)
  • Soon, we may be able to better care for patients by using a risk-adapted strategy based on a combination model of clinical, radiographic, laboratory, and genetic risk factors. (sciencemag.org)
  • Clinical, angiographic, and genetic factors associated with early coronary stent thrombosis. (sciencemag.org)
  • Novartis) and certain drugs that demonstrate variable efficacy or adverse effects that are attributed to metabolizing enzymes, for most drugs, the genetic variations that determine their clinical response remain uncovered. (nih.gov)
  • Applied Genetic Technologies Corp is a clinical-stage biotechnology company. (equities.com)
  • To identify demographic, clinical, genetic, immunologic and/or microbial (i.e., fecal stream characterization) risk factors that influence the likelihood of development of the HAEC phenotype in children who carry the diagnosis of HD. (centerwatch.com)
  • The presence of different alleles due to a distorted segregation at the genetic markers is indicative of the difference between selected and non-selected livestock. (wikipedia.org)
  • Similarly, datasets gathered on short tandem repeat (STR) markers with different protocols can be computationally adjusted to enlarge samples for joint analysis when sets of alleles at individual markers differ between datasets ( 4 , 5 ). (pnas.org)
  • Therefore, some marker alleles will be correlated with positive effects on the quantitative trait across all families and can be used for selection without the need to establish linkage phase in each family. (genetics.org)
  • The accessions were also described morphologically, and all characterization methods were evaluated against the genetic diversity assessed by a panel of three crop experts. (wur.nl)
  • Molecular tools were used for genetic characterization of 7000 georeferenced biological samples taken from livestock during inventories. (innovations-report.com)
  • W. Okello-Anyanga, K. Hansel-Hohl, A. Burg, S. Gaubitzer, P. R. Rubaihayo, J. Vollmann, P. T. Gibson, S. Fluch, E. M. Sehr (2017) Towards the selection of superior sesame lines based on genetic and phenotypic characterization for Uganda. (ait.ac.at)
  • The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus that causes COVID-19, is commonly thought to be a zoonotic disease that originated in bats and then subsequently jumped to humans. (news-medical.net)
  • Yet, whether the virus directly jumped to humans or through an intermediate host is still unclear. (news-medical.net)
  • The study findings suggest that there may be a common mechanism by which coronaviruses mutate for them to jump from animal hosts to humans. (news-medical.net)
  • Although the functional significance of these findings is uncertain, these haplotypes could be susceptibility markers for DA and may be useful aids in the diagnosis of DA. (cdc.gov)
  • The species now only exists in captivity, and there is a substantial risk of genetic drift due to inbreeding and interspecific crossing. (innovations-report.com)
  • However, the usefulness of information from a sparse marker map in outbreeding species is limited because the linkage phase between a marker and QTL must be established for every family in which the marker is to be used for selection. (genetics.org)
  • Wild species are important sources of genetic variability and may be exploited by breeding programs. (scielo.br)
  • Analysis of the genetic relationships among Thai gibbon species using AFLP markers. (scialert.net)
  • Information about genetic diversity is a key component for the creation of novel and desirable germplasm to develop elite pea breeding lines. (bioone.org)
  • However, little is known about the structure and the genetic diversity of the pomegranate germplasm in this area. (scielo.cl)
  • A core collection of the common bean ( Phaseolus vulgaris L.), representing genetic diversity in the entire Mexican holding, is kept at the INIFAP (Instituto Nacional de Investigaciones Forestales, Agricolas y Pecuarias, Mexico) Germplasm Bank. (scielo.br)
  • Genetic diversity observed in the common-bean core collection represents an important sample of the total Phaseolus genetic variability at the main Germplasm Bank of INIFAP. (scielo.br)
  • 2007). Concomitantly, genetic diversity is being maintained at the INIFAP Germplasm Bank located near Texcoco. (scielo.br)
  • This study analyzes the level of genetic diversity of L. tulipifera germplasm by using SSR markers . (omicsonline.org)
  • E.-M. Halbauer, V. Bohinec, M. Wittenberger, K. Hansel-Hohl, S. Gaubitzer, E. M. Sehr (2017) Genetic diversity of flax accessions originating in the Alpine region - a case study for ex situ germplasm evaluation based on molecular markers. (ait.ac.at)
  • After comparing the DNA of thousands of people with and without the disease, a new study has identified five genetic markers for pancreatic cancer that raise the risk for developing the deadly disease. (medicalnewstoday.com)
  • This new study brings to nine the total number of significant genetic markers that the scientists have discovered for pancreatic cancer. (medicalnewstoday.com)
  • A new large-scale international study expands the number of genetic markers now known to be associated with exceptional longevity. (eurekalert.org)
  • This study will attempt to identify genetic factors associated with the development of FSGS. (clinicaltrials.gov)
  • The results of this study are useful in distinguishing between the two black pig breeds and can be used as a foundation for further development of DNA markers. (nih.gov)
  • A research study led by the Peninsula College of Medicine and Dentistry, University of Exeter, and Boston University School of Medicine, in collaboration with a global consortium, has identified genetic markers that influence a protein involved in regulating oestrogen and testosterone levels in the bloodstream. (fiercebiotech.com)
  • The study was carried out in collaboration with the Framingham Heart Study and investigators from 15 international epidemiologic studies participating in the Cohorts for Heart and Aging Research in Genetic Epidemiology (CHARGE) consortium. (fiercebiotech.com)
  • This study aims to identify known genetic causes of heart rhythm and sudden death related disorders in patients with epilepsy. (mayo.edu)
  • Pulmonologists and geneticists in the Lung Center at Brigham and Women's Hospital are developing a novel study incorporating genetic testing to identify patients at risk for pulmonary fibrosis with the goal of detecting and treating the disease at earlier stages. (brighamandwomens.org)
  • Testing of first-degree relatives (siblings and children) in this study will include CT scanning, pulmonary function testing, and genetic testing. (brighamandwomens.org)
  • In addition to exploring whether genetic testing can help in the earlier diagnosis of pulmonary fibrosis, an important part of this study is to understand whether or not providing otherwise- healthy family members with the results of their genetic tests causes more harm than good," said Dr. Raby. (brighamandwomens.org)
  • 2003) Study on Population Genetic Diversity and Genetic Differentiation of Disanthus Cercidifolius Maxim var. (scirp.org)
  • In this study, twenty seven bermudagrass accessions and introductions, mostly from different parts of Iran, were assayed by inter-simple sequence repeat (ISSR) markers to differentiate and explore their genetic relationships. (biomedsearch.com)
  • The Nottingham study aimed to identify molecular markers as a first step to improving the treatments and therapies available to fight the cancer. (healthcanal.com)
  • Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: a genotype-phenotype association study. (nih.gov)
  • As Torres, the only Spanish researcher participating in the study published today in the journal Scientific Reports , explains to SINC: "The cell activation markers most used today are pERK1/2 and c-Fos, but both have their limitations. (medindia.net)
  • Scientists can take this new genetic tool and study different infectious diseases in these world-class research facilities. (farmprogress.com)
  • The road to answering these questions may have a lot to do with specific genetic factors that vary from individual to individual, a new study in rats suggests. (technologynetworks.com)
  • However, limited data from a previous study suggest a similar decay rate between host-associated and QPCR-measured Enterococcus, E. coli and Bacteroidales genetic markers suggesting that apportionment may be possible for these organisms, however further work is needed to confirm. (epa.gov)
  • Recently, a new screening study was able to identify 153 children with genetic markers of T1D. (jdrf.org)
  • 1 kb, CNVs are the most common type of variations in genetic structure. (medpagetoday.com)
  • The most likely area of DNA for genetic variations that predispose to drug hypersensitivity reactions is the human leukocyte antigen (HLA) region ( Box 1 ). (mja.com.au)
  • If that great-grandmother happened to have the genetic variations that have been labeled A, B, C, D, or X, then, by having the same mtDNA yourself, you will have inherited a "Native American" mtDNA marker. (councilforresponsiblegenetics.org)
  • In some embodiments, the specimens may be tissue specimens from different tumors, which are subjected to multiple parallel molecular (including genetic and immunological) analyses. (google.com)
  • The results of the parallel analyses are then used to detect common molecular characteristics of the genetic disorder type, which can subsequently be used in the diagnosis or treatment of the disease. (google.com)
  • Manifold analyses and corrections were required to maximize core collection representation and increase use in genetic breeding programs. (scielo.br)
  • In 2004, he and his students at the University of North Carolina at Chapel Hill used genetic analyses to identify red snapper, finding out that a significant number of the fish sold in markets were not what were advertised. (bio-medicine.org)
  • Seeking new pain markers continues to be very important in the field of nociception, which analyses the subjective experience of pain, and a need that has not yet been met," adds Torres P rez. (medindia.net)
  • Wrensch suggested that once these or similar molecular markers are accepted by clinicians as part of the classification system, "it may make a great deal of difference in treatment approach for individual patients. (eurekalert.org)
  • In the long run, studies that demonstrate a genetic basis for FSGS may help us identify patients earlier and may lead to improved therapies. (clinicaltrials.gov)
  • But knowing individuals' genetic risk could allow clinicians to identify high-risk patients and screen them at a younger age and more frequently, while those with lower risk may need less-frequent screening, Simard says. (theglobeandmail.com)
  • The work of Dr. Eng and her colleagues indicates that genetic alterations within breast cancer tumors are likely the prime reason for the variability among patients. (emaxhealth.com)
  • Earlier work by this team has shown that patients with IPF and those with early stages of pulmonary fibrosis share a high prevalence of specific genetic determinants (N Engl J Med. (brighamandwomens.org)
  • The Xpert Carba-R Assay tests specimens directly taken from patients, which are usually obtained by rectal swabs, for the presence of five different genetic markers that are associated with carbapenemase, the enzyme produced by CRE. (fda.gov)
  • The challenge became how to find a way to exploit this genetic deficiency to better treat these patients. (mcgill.ca)
  • Thus, it is anticipated that genetic research will soon generate new information that can be used to develop novel therapeutic strategies and diagnostic tests that will ultimately lead to safer and more efficacious drugs for all patients. (nih.gov)
  • Genetic testing for HOXB13-CIP2A could help identify these patients sooner and may bring new opportunities for the early detection and precision oncology in prostate cancer. (utu.fi)
  • Serological and biochemical genetic markers in 76 patients with cleft lip with or without cleft palate [CL(P)] and 24 patients with isolated cleft palate (CP) were studied and compared with healthy control subjects. (biomedsearch.com)
  • Identifying this genetic marker continues to move toward precision medicine that we are seeing today, where health care providers can develop specific treatment plans based on the individual needs of patients," Dunn said in the press program. (healio.com)
  • The number of patients who died was also slight in cases where one or the other marker was found. (southlakeoncology.com)
  • When patients presented with both markers, however, the mortality rate rose to nearly 23 percent. (southlakeoncology.com)
  • Now it is possible to perform rigorous studies of the genetic, immune, and microbial differences in HD patients who develop HAEC compared with those children with HD that have not developed HAEC. (centerwatch.com)
  • Assessment of Genetic Diversity of Bermudagrass (Cynodon dactylon) Using ISSR Markers. (biomedsearch.com)
  • Assessment of Genetic Diversity in Opuntia spp. (mdpi.com)
  • Ribeiro, M.M. Assessment of Genetic Diversity in Opuntia spp. (mdpi.com)
  • Reis CMG, Raimundo J, Ribeiro MM. Assessment of Genetic Diversity in Opuntia spp. (mdpi.com)
  • A team of scientists from UC San Francisco and Mayo Clinic has shown that using just three molecular markers will help clinicians classify gliomas - the most common type of malignant brain tumors - more accurately than current methods. (eurekalert.org)
  • The scientists found that among grade II and III tumors, 29 percent were "triple positive," showing all three markers. (eurekalert.org)
  • But scientists at The University of Nottingham in the U.K. have identified genetic markers that they think will lead to vital new diagnostics for the condition. (fiercebiotech.com)
  • By identifying new genetic markers associated with breast-cancer risk, scientists envision a future in which a simple genetic test applied to the general population could determine which individuals need earlier and more frequent screening. (theglobeandmail.com)
  • The project, which involved some 550 scientists around the world and was carried out by the OncoArray Consortium, exemplifies the kind of collaborative research involved in pursuing personalized medicine, where treatment and interventions can be tailored to individuals based on their genetic profiles. (theglobeandmail.com)
  • A new genetic marker associated with ovarian cancer risk was recently discovered by an international research group, led by scientists from the Cancer Research Genetic Epidemiology Unit in the United Kingdom. (innovations-report.com)
  • Drs. Marc Goodman, Galina Lurie, Michael Carney, and Keith Terada of the University of Hawai'i at Mânoa's Cancer Research Center of Hawai'i participated in the validation of the discovered genetic marker as a part of the Ovarian Cancer Association Consortium, a worldwide forum of scientists performing ovarian cancer research. (innovations-report.com)
  • An international group of investigators led by scientists at Memorial Sloan Kettering Cancer Center (MSKCC) and the National Cancer Institute has identified a new genetic marker of risk for breast cancer . (mskcc.org)
  • Genetic and serological markers (antibodies) may have a role in identifying unclassified colitis. (edu.mt)
  • Serological and biochemical genetic markers in congenital cleft lip and cleft palate anomalies. (biomedsearch.com)
  • 1e: To collect serum samples at the time of recruitment in a subset cohort (n=50 HD only, n=50 HD + HAEC) for serological immune markers known for inflammatory bowel disease (IBD) including ANCA, ASCA, OMPC, I2, and CBir1 and any newly identified markers. (centerwatch.com)
  • These genetic markers might make it easier to determine the necessity, as well as the rate, of regular prostate cancer screenings. (medicalnewstoday.com)
  • These recent findings increase the known prostate cancer genetic markers by more than 50 percent. (medicalnewstoday.com)
  • With these data, they were able to identify 63 new genetic markers in those with prostate cancer - markers that did not appear in the DNA of men without the disease. (medicalnewstoday.com)
  • He also notes that this "genetic score" might be an important factor that doctors consider when approaching prostate cancer treatment, as well. (medicalnewstoday.com)
  • If the data are confirmed, the marker may help clinicians personalize prostate cancer screening. (biologynews.net)
  • Genetic testing for prostate cancer is not yet clinically well characterized as it is for breast, ovarian cancer and colon cancer," Giri says. (biologynews.net)
  • They then evaluated this marker in 183 Caucasian men who have a family history of prostate cancer undergoing follow-up in the Prostate Cancer Risk Assessment Program. (biologynews.net)
  • A genetic marker may be a short DNA sequence, such as a sequence surrounding a single base-pair change ( single nucleotide polymorphism , SNP), or a long one, like minisatellites . (wikipedia.org)
  • Ferriol, M., Pico, B., de Cordova, P.F. and Nuez, F. (2004) Molecular Diversity of a Germ Plasm Collection of Squash (Cucurbita moschata) Determined by SRAP and AFLP Markers. (scirp.org)
  • Through the Ovarian Cancer Association Consortium, the most promising markers were subsequently investigated among an additional 7,922 women with ovarian cancer and 10,577 women without disease. (innovations-report.com)
  • These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. (sbir.gov)
  • The markers will alsobe amenable to fluorescent analysis rather than requiring radioactive detection. (sbir.gov)
  • Genetic Diversity Analysis of Cotoneaster schantungensis Klotz. (scirp.org)
  • Ji, Z.X. and Li, J.M. (2007) ISSR Analysis on Genetic Diversity of Endangered Relic Shrub Sinocanthus chinensis. (scirp.org)
  • 2007) Genetic Diversity of Endangered Plant Monimopetalumchinense in China Detected by ISSR Analysis. (scirp.org)
  • This includes the 48-capillary 3730 DNA Analyzer for medium to high throughput genetic analysis. (thepoultrysite.com)
  • Applied Biosystems is a global leader in the development and commercialization of instrument-based systems, consumables, software, and services for the life-science market and has set the standard for quality genetic analysis by providing the most robust line of capillary electrophoresis (CE) systems available in the market. (thepoultrysite.com)
  • The data was transferred to Iowa State University for genetic analysis that led to the discovery of the QTL. (farmprogress.com)
  • There are even several companies that claim to be able to help people determine their Native American heritage with genetic analysis. (councilforresponsiblegenetics.org)
  • Another problem is that genetic analysis, and some of the processes involved, can be problematic for indigenous people in terms of their own cultural knowledge. (councilforresponsiblegenetics.org)
  • Put simply, there are things involved in genetic analysis that some indigenous cultures consider violations of their principles or values. (councilforresponsiblegenetics.org)
  • The point that is frequently lost in the debate about using genetic analysis to determine whether one is Native American is that the genetic analysis itself is not conclusive, even on strictly scientific terms. (councilforresponsiblegenetics.org)
  • This article will explain the scientific shortcomings of trying to use genetic analysis to prove native identity. (councilforresponsiblegenetics.org)
  • For a complete fundamental analysis analysis of Applied Genetic Technologies Corp, check out Equities.com's Stock Valuation Analysis report for AGTC . (equities.com)
  • Technically, the team in which the Spanish expert works has demonstrated in mice that a population of superficial neurons in the spinal cord controls an epigenetic marker known as pS10H3. (medindia.net)
  • It's also the first demonstration that a DNA tag called an epigenetic marker can predispose an individual to addiction and relapse. (technologynetworks.com)
  • The article Why Applied Genetic Technologies Corporation Stock Jumped Today originally appeared on Fool.com. (foxbusiness.com)
  • Genetic markers associated with certain diseases can often be detected in the blood serum, where their presence is used to determine whether a person is at high risk for developing a disease. (yourdictionary.com)
  • Ethnicity has been associated with the incidence of diseases and consequently it is a cornerstone in medical genetic studies. (scirp.org)
  • Genetic diversity in a selected set of 80 Lactuca accessions was estimated using the anonymous marker systems SSR, AFLP and SSAP, and the targeted marker systems SRAP, TRAP and NBS profiling. (wur.nl)
  • AFLP indicated that the highest genetic diversity was to be found in ten commercial-seed classes from two major groups of accessions from Central Mexico and Chiapas, which seems to be an important center of diversity in the south. (scielo.br)
  • It can be concluded that there exists a wide genetic base of bermudograss in Iran and that ISSR markers are effective in determining genetic diversity and relationships among them. (biomedsearch.com)
  • In this article, the common uses and potential applications of different retrotransposon-based marker types in agricultural biotechnology will be discussed. (doaj.org)
  • They occur in less than 1 per cent of women, Simard says, whereas some of the newly identified genetic markers are much more common. (theglobeandmail.com)
  • however, their concentrations are not necessarily amenable to source apportionment because the markers may differ in prevalence across sources. (epa.gov)
  • This discovery could potentially lead to an early genetic test, which could help reveal those who are most at risk for Alzheimer's - leading to earlier, more effective treatments. (foxnews.com)
  • Much of the genetic research on Alzheimer's centers on amyloid-beta, a key component of brain plaques that build up in the brains of people with the disease. (healthcanal.com)
  • Even so, the results were promising because they showed that if you don't have the genetic marker for Alzheimer's disease, you stand a very good chance of avoiding it altogether by use of the supplement. (inquisitr.com)
  • According to the Forbes report, "it's still possible that starting fish oil supplementation during or before middle age could protect against developing Alzheimer's even for people with the genetic marker. (inquisitr.com)
  • Blood group A phenotype and homozygous plasma haptoglobin (2-2) were found associated with CL(P). The findings suggest that the individuals possessing these markers are more likely to develop congenital CL(P). (biomedsearch.com)
  • Thus, well-designed, multi-disciplinary investigations of genetic, immune and microbial etiologies of HAEC, with sufficient power to detect differences in disease phenotype are critically needed. (centerwatch.com)
  • The reliability of the inferences derived from any genetic marker is a function of three properties: (1) mode of inheritance, (2) stability, and (3) rarity. (encyclopedia.com)
  • The mode of inheritance of a genetic marker may be quite variable. (encyclopedia.com)
  • Simple sequence repeats (SSRs) are useful molecular markers for genetic mapping and variety identification. (dovepress.com)
  • Furthermore, molecular genetic markers were used to resolve the issue of natural transmission, the breed of origin ( phylogenetics ), and the age of the canine tumor. (wikipedia.org)
  • Recent advances in molecular genetic techniques will make dense marker maps available and genotyping many individuals for these markers feasible. (genetics.org)
  • Others use nuclear DNA markers from small samples of diverse peoples as a baseline to establish a customer's "racial" affiliation, which simply expresses an overall pattern of similarity to one or more of these standard samples. (encyclopedia.com)
  • Genetic similarity values ranged from 0.074 (between Maple pea NZ and Line 45760) to 0.875 (between Galena and Dakota) with an average of 0.336. (bioone.org)
  • Now we have a genetic marker to potentially help differentiate between transient and persistent wheezers. (sun-sentinel.com)
  • Can genotype records that rely on disjoint sets of markers be linked? (pnas.org)
  • No genetic differences were found between the inermis form, O. ficus-indica f. ficus-indica , and the rewilded spiny one, O . ficus-indica f. amyclaea . (mdpi.com)
  • Torres found that blocking a new genetic marker can reduce the neural activation caused by painful stimuli. (medindia.net)
  • Further, they found that the genetic adaptations identified were similar to those made by the severe acute respiratory syndrome coronavirus (SARS-CoV), which caused the 2002-2003 severe acute respiratory syndrome (SARS) outbreak. (news-medical.net)
  • Questionnaires developed here will help us to assess the psychosocial impact of the disclosure of genetic test results. (brighamandwomens.org)
  • Richard Rosenquist Brandell conducts research into how leukaemias arise, and how genetic markers can be used to assess prognosis and to select the most effective treatment. (ki.se)