AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Genetic LinkageGenetic MarkersChromosome MappingLod ScorePedigreeMicrosatellite RepeatsLinkage DisequilibriumQuantitative Trait LociCrosses, GeneticGenotypePolymorphism, Restriction Fragment LengthGenes, DominantGenome, PlantPhysical Chromosome MappingPolymorphism, GeneticAllelesModels, GeneticRecombination, GeneticHaplotypesChromosomes, PlantChromosomes, Human, Pair 2SyntenyChromosomes, Human, Pair 1Genetic HeterogeneityChromosomes, Artificial, BacterialExpressed Sequence TagsPolymorphism, Single NucleotideGenetic Predisposition to DiseaseAmplified Fragment Length Polymorphism AnalysisDendrobiumQuantitative Trait, HeritableSequence Tagged SitesChromosomes, Human, Pair 5Molecular Sequence DataGenomePhenotypeFamily HealthChromosomes, Human, Pair 10Chromosomes, Human, Pair 3Genes, RecessiveChromosomes, Human, Pair 12Chromosomes, Human, Pair 11Chromosomes, Human, Pair 4Base SequenceChromosomes, Human, Pair 16Nuclear FamilyHeterozygote DetectionCatfishesDNA, PlantX ChromosomePenetranceGenome, HumanChromosomes, Human, Pair 6Hybridization, GeneticChromosomes, Human, Pair 19Sequence Analysis, DNAMutationGenetic LociGenetic VariationSiblingsShiitake MushroomsLupinusChromosomesChromosomes, Human, Pair 7Gene FrequencySinapisSonchusNelumboGentianaceaeChromosomes, HumanGenes, PlantLikelihood FunctionsGenetic Diseases, InbornChromosomes, Human, Pair 17FlounderParanoid Personality DisorderRadiation Hybrid MappingChromosomes, MammalianBrassica rapaGenomicsCrossing Over, GeneticEucalyptusDNA ProbesLecythidaceaeChromosomes, Human, Pair 20Fibromatosis, GingivalEpidermolysis Bullosa DystrophicaSpecies SpecificityDNA, SatelliteContig MappingGenetics, PopulationRandom Amplified Polymorphic DNA TechniqueSoftwarePleurotusTrifoliumGenome-Wide Association StudyDNAGenotyping TechniquesArachis hypogaeaPolymerase Chain Reaction
Genetic Linkage
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Genetic Markers
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Chromosome Mapping
Any method used for determining the location of and relative distances between genes on a chromosome.
Lod Score
The total relative probability, expressed on a logarithmic scale, that a linkage relationship exists among selected loci. Lod is an acronym for "logarithmic odds."
Pedigree
The record of descent or ancestry, particularly of a particular condition or trait, indicating individual family members, their relationships, and their status with respect to the trait or condition.
Microsatellite Repeats
A variety of simple repeat sequences that are distributed throughout the GENOME. They are characterized by a short repeat unit of 2-8 basepairs that is repeated up to 100 times. They are also known as short tandem repeats (STRs).
Linkage Disequilibrium
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
Quantitative Trait Loci
Genetic loci associated with a QUANTITATIVE TRAIT.
Crosses, Genetic
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
Genotype
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Polymorphism, Restriction Fragment Length
Variation occurring within a species in the presence or length of DNA fragment generated by a specific endonuclease at a specific site in the genome. Such variations are generated by mutations that create or abolish recognition sites for these enzymes or change the length of the fragment.
Genes, Dominant
Genes that influence the PHENOTYPE both in the homozygous and the heterozygous state.
Genome, Plant
The genetic complement of a plant (PLANTS) as represented in its DNA.
Physical Chromosome Mapping
Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
Polymorphism, Genetic
The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.
Alleles
Variant forms of the same gene, occupying the same locus on homologous CHROMOSOMES, and governing the variants in production of the same gene product.
Models, Genetic
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
Recombination, Genetic
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
Haplotypes
The genetic constitution of individuals with respect to one member of a pair of allelic genes, or sets of genes that are closely linked and tend to be inherited together such as those of the MAJOR HISTOCOMPATIBILITY COMPLEX.
Chromosomes, Plant
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
Chromosomes, Human, Pair 2
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Synteny
The presence of two or more genetic loci on the same chromosome. Extensions of this original definition refer to the similarity in content and organization between chromosomes, of different species for example.
Chromosomes, Human, Pair 1
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Genetic Heterogeneity
The presence of apparently similar characters for which the genetic evidence indicates that different genes or different genetic mechanisms are involved in different pedigrees. In clinical settings genetic heterogeneity refers to the presence of a variety of genetic defects which cause the same disease, often due to mutations at different loci on the same gene, a finding common to many human diseases including ALZHEIMER DISEASE; CYSTIC FIBROSIS; LIPOPROTEIN LIPASE DEFICIENCY, FAMILIAL; and POLYCYSTIC KIDNEY DISEASES. (Rieger, et al., Glossary of Genetics: Classical and Molecular, 5th ed; Segen, Dictionary of Modern Medicine, 1992)
Chromosomes, Artificial, Bacterial
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
Expressed Sequence Tags
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
Polymorphism, Single Nucleotide
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
Genetic Predisposition to Disease
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Amplified Fragment Length Polymorphism Analysis
The detection of RESTRICTION FRAGMENT LENGTH POLYMORPHISMS by selective PCR amplification of restriction fragments derived from genomic DNA followed by electrophoretic analysis of the amplified restriction fragments.
Dendrobium
A plant genus of the family ORCHIDACEAE that contains dihydroayapin (COUMARINS) and phenanthraquinones.
Quantitative Trait, Heritable
A characteristic showing quantitative inheritance such as SKIN PIGMENTATION in humans. (From A Dictionary of Genetics, 4th ed)
Sequence Tagged Sites
Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.
Chromosomes, Human, Pair 5
One of the two pairs of human chromosomes in the group B class (CHROMOSOMES, HUMAN, 4-5).
Molecular Sequence Data
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
Genome
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Phenotype
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Family Health
The health status of the family as a unit including the impact of the health of one member of the family on the family as a unit and on individual family members; also, the impact of family organization or disorganization on the health status of its members.
Chromosomes, Human, Pair 10
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 3
A specific pair of human chromosomes in group A (CHROMOSOMES, HUMAN, 1-3) of the human chromosome classification.
Genes, Recessive
Genes that influence the PHENOTYPE only in the homozygous state.
Chromosomes, Human, Pair 12
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 11
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 4
A specific pair of GROUP B CHROMOSOMES of the human chromosome classification.
Base Sequence
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Chromosomes, Human, Pair 16
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Nuclear Family
A family composed of spouses and their children.
Heterozygote Detection
Identification of genetic carriers for a given trait.
Catfishes
Common name of the order Siluriformes. This order contains many families and over 2,000 species, including venomous species. Heteropneustes and Plotosus genera have dangerous stings and are aggressive. Most species are passive stingers.
DNA, Plant
Deoxyribonucleic acid that makes up the genetic material of plants.
X Chromosome
The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.
Penetrance
The percent frequency with which a dominant or homozygous recessive gene or gene combination manifests itself in the phenotype of the carriers. (From Glossary of Genetics, 5th ed)
Genome, Human
The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.
Chromosomes, Human, Pair 6
A specific pair GROUP C CHROMSOMES of the human chromosome classification.
Hybridization, Genetic
The genetic process of crossbreeding between genetically dissimilar parents to produce a hybrid.
Chromosomes, Human, Pair 19
A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.
Sequence Analysis, DNA
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
Mutation
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Genetic Loci
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Genetic Variation
Genotypic differences observed among individuals in a population.
Siblings
Persons or animals having at least one parent in common. (American College Dictionary, 3d ed)
Shiitake Mushrooms
Mushrooms in the order AGARICALES containing B vitamins, cortinelin, and the polysaccharide LENTINAN.
Lupinus
A plant genus of the family FABACEAE that is a source of SPARTEINE, lupanine and other lupin alkaloids.
Chromosomes
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Chromosomes, Human, Pair 7
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Gene Frequency
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
Sinapis
A plant genus of the family BRASSICACEAE. The common name of white mustard sometimes refers to other plants (MUSTARD PLANT).
Sonchus
A plant genus of the family ASTERACEAE. Sesquiterpene lactone glucosides (SESQUITERPENES) have been found in it.
Nelumbo
A plant genus of the family NELUMBONACEAE. The common name of lotus is also for LOTUS and NYMPHAEA.
Gentianaceae
A plant family of the order Gentianales, subclass Asteridae, class Magnoliopsida.
Chromosomes, Human
Very long DNA molecules and associated proteins, HISTONES, and non-histone chromosomal proteins (CHROMOSOMAL PROTEINS, NON-HISTONE). Normally 46 chromosomes, including two sex chromosomes are found in the nucleus of human cells. They carry the hereditary information of the individual.
Genes, Plant
The functional hereditary units of PLANTS.
Likelihood Functions
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
Genetic Diseases, Inborn
Diseases that are caused by genetic mutations present during embryo or fetal development, although they may be observed later in life. The mutations may be inherited from a parent's genome or they may be acquired in utero.
Chromosomes, Human, Pair 17
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Flounder
Common name for two families of FLATFISHES belonging to the order Pleuronectiformes: left-eye flounders (Bothidae) and right-eye flounders (Pleuronectidae). The latter is more commonly used in research.
Paranoid Personality Disorder
A personality disorder characterized by the avoidance of accepting deserved blame and an unwarranted view of others as malevolent. The latter is expressed as suspiciousness, hypersensitivity, and mistrust.
Radiation Hybrid Mapping
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
Chromosomes, Mammalian
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of MAMMALS.
Brassica rapa
A plant species cultivated for the seed used as animal feed and as a source of canola cooking oil.
Genomics
The systematic study of the complete DNA sequences (GENOME) of organisms.
Crossing Over, Genetic
The reciprocal exchange of segments at corresponding positions along pairs of homologous CHROMOSOMES by symmetrical breakage and crosswise rejoining forming cross-over sites (HOLLIDAY JUNCTIONS) that are resolved during CHROMOSOME SEGREGATION. Crossing-over typically occurs during MEIOSIS but it may also occur in the absence of meiosis, for example, with bacterial chromosomes, organelle chromosomes, or somatic cell nuclear chromosomes.
Eucalyptus
A genus of trees of the Myrtaceae family, native to Australia, that yields gums, oils, and resins which are used as flavoring agents, astringents, and aromatics.
DNA Probes
Species- or subspecies-specific DNA (including COMPLEMENTARY DNA; conserved genes, whole chromosomes, or whole genomes) used in hybridization studies in order to identify microorganisms, to measure DNA-DNA homologies, to group subspecies, etc. The DNA probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the DNA probe include the radioisotope labels 32P and 125I and the chemical label biotin. The use of DNA probes provides a specific, sensitive, rapid, and inexpensive replacement for cell culture techniques for diagnosing infections.
Lecythidaceae
A plant family of the order Lecythidales, subclass Dilleniidae, class Magnoliopsida.
Chromosomes, Human, Pair 20
A specific pair of GROUP F CHROMOSOMES of the human chromosome classification.
Fibromatosis, Gingival
Generalized or localized diffuse fibrous overgrowth of the gingival tissue, usually transmitted as an autosomal dominant trait, but some cases are idiopathic and others produced by drugs. The enlarged gingiva is pink, firm, and has a leather-like consistency with a minutely pebbled surface and in severe cases the teeth are almost completely covered and the enlargement projects into the oral vestibule. (Dorland, 28th ed)
Epidermolysis Bullosa Dystrophica
Form of epidermolysis bullosa characterized by atrophy of blistered areas, severe scarring, and nail changes. It is most often present at birth or in early infancy and occurs in both autosomal dominant and recessive forms. All forms of dystrophic epidermolysis bullosa result from mutations in COLLAGEN TYPE VII, a major component fibrils of BASEMENT MEMBRANE and EPIDERMIS.
Species Specificity
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
DNA, Satellite
Highly repetitive DNA sequences found in HETEROCHROMATIN, mainly near centromeres. They are composed of simple sequences (very short) (see MINISATELLITE REPEATS) repeated in tandem many times to form large blocks of sequence. Additionally, following the accumulation of mutations, these blocks of repeats have been repeated in tandem themselves. The degree of repetition is on the order of 1000 to 10 million at each locus. Loci are few, usually one or two per chromosome. They were called satellites since in density gradients, they often sediment as distinct, satellite bands separate from the bulk of genomic DNA owing to a distinct BASE COMPOSITION.
Contig Mapping
Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
Genetics, Population
The discipline studying genetic composition of populations and effects of factors such as GENETIC SELECTION, population size, MUTATION, migration, and GENETIC DRIFT on the frequencies of various GENOTYPES and PHENOTYPES using a variety of GENETIC TECHNIQUES.
Random Amplified Polymorphic DNA Technique
Technique that utilizes low-stringency polymerase chain reaction (PCR) amplification with single primers of arbitrary sequence to generate strain-specific arrays of anonymous DNA fragments. RAPD technique may be used to determine taxonomic identity, assess kinship relationships, analyze mixed genome samples, and create specific probes.
Software
Sequential operating programs and data which instruct the functioning of a digital computer.
Pleurotus
A genus of basidiomycetous fungi, family POLYPORACEAE, order POLYPORALES, that grows on logs or tree stumps in shelflike layers. The species P. ostreatus, the oyster mushroom, is a choice edible species and is the most frequently encountered member of the genus in eastern North America. (Alexopoulos et al., Introductory Mycology, 4th ed, p531)
Trifolium
A plant genus of the family FABACEAE.
Genome-Wide Association Study
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
DNA
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Genotyping Techniques
Methods used to determine individuals' specific ALLELES or SNPS (single nucleotide polymorphisms).
Arachis hypogaea
A plant species of the family FABACEAE that yields edible seeds, the familiar peanuts, which contain protein, oil and lectins.
Polymerase Chain Reaction
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Chromosomes, Human, Pair 9
A specific pair of GROUP C CHROMSOMES of the human chromosome classification.
Inheritance Patterns
The different ways GENES and their ALLELES interact during the transmission of genetic traits that effect the outcome of GENE EXPRESSION.
Sex Chromosomes
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)
Age of Onset
The age, developmental stage, or period of life at which a disease or the initial symptoms or manifestations of a disease appear in an individual.
Genetic Testing
Detection of a MUTATION; GENOTYPE; KARYOTYPE; or specific ALLELES associated with genetic traits, heritable diseases, or predisposition to a disease, or that may lead to the disease in descendants. It includes prenatal genetic testing.
Sheep, Bighorn
A species of sheep, Ovis canadensis, characterized by massive brown horns. There are at least four subspecies and they are all endangered or threatened.
Chromosomes, Human, Pair 15
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Computer Simulation
Computer-based representation of physical systems and phenomena such as chemical processes.
DNA Mutational Analysis
Biochemical identification of mutational changes in a nucleotide sequence.
Cyprinodontiformes
An order of fish with eight families and numerous species of both egg-laying and livebearing fish. Families include Cyprinodontidae (egg-laying KILLIFISHES;), FUNDULIDAEl; (topminnows), Goodeidae (Mexican livebearers), Jenynsiidae (jenynsiids), Poeciliidae (livebearers), Profundulidae (Middle American killifishes), Aplocheilidae, and Rivulidae (rivulines). In the family Poeciliidae, the guppy and molly belong to the genus POECILIA.
In Situ Hybridization, Fluorescence
A type of IN SITU HYBRIDIZATION in which target sequences are stained with fluorescent dye so their location and size can be determined using fluorescence microscopy. This staining is sufficiently distinct that the hybridization signal can be seen both in metaphase spreads and in interphase nuclei.
Chromosomes, Human, Pair 13
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Syndrome
A characteristic symptom complex.
Minisatellite Repeats
Tandem arrays of moderately repetitive, short (10-60 bases) DNA sequences which are found dispersed throughout the GENOME, at the ends of chromosomes (TELOMERES), and clustered near telomeres. Their degree of repetition is two to several hundred at each locus. Loci number in the thousands but each locus shows a distinctive repeat unit.
Chromosomes, Human, Pair 14
A specific pair of GROUP D CHROMOSOMES of the human chromosome classification.
Genes
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Pigmentation
Coloration or discoloration of a part by a pigment.
Gene Library
A large collection of DNA fragments cloned (CLONING, MOLECULAR) from a given organism, tissue, organ, or cell type. It may contain complete genomic sequences (GENOMIC LIBRARY) or complementary DNA sequences, the latter being formed from messenger RNA and lacking intron sequences.
Hyperkeratosis, Epidermolytic
A form of congenital ichthyosis inherited as an autosomal dominant trait and characterized by ERYTHRODERMA and severe hyperkeratosis. It is manifested at birth by blisters followed by the appearance of thickened, horny, verruciform scales over the entire body, but accentuated in flexural areas. Mutations in the genes that encode KERATIN-1 and KERATIN-10 have been associated with this disorder.
Amino Acid Sequence
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Hybrid Cells
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
DNA Primers
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Homozygote
An individual in which both alleles at a given locus are identical.
Centromere
The clear constricted portion of the chromosome at which the chromatids are joined and by which the chromosome is attached to the spindle during cell division.
Epistasis, Genetic
A form of gene interaction whereby the expression of one gene interferes with or masks the expression of a different gene or genes. Genes whose expression interferes with or masks the effects of other genes are said to be epistatic to the effected genes. Genes whose expression is affected (blocked or masked) are hypostatic to the interfering genes.
Chromosomes, Human, Pair 18
A specific pair of GROUP E CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 22
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Chromosomes, Human, Pair 8
A specific pair of GROUP C CHROMOSOMES of the human chromosome classification.
Cosmids
Plasmids containing at least one cos (cohesive-end site) of PHAGE LAMBDA. They are used as cloning vehicles.
Lotus
A plant genus of the family FABACEAE. This genus was formerly known as Tetragonolobus. The common name of lotus is also used for NYMPHAEA and NELUMBO.
Multigene Family
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
Algorithms
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
Restriction Mapping
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
Chromosome Segregation
The orderly segregation of CHROMOSOMES during MEIOSIS or MITOSIS.
Blotting, Southern
A method (first developed by E.M. Southern) for detection of DNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Genomic Library
A form of GENE LIBRARY containing the complete DNA sequences present in the genome of a given organism. It contrasts with a cDNA library which contains only sequences utilized in protein coding (lacking introns).
Cloning, Molecular
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Chromosome Banding
Staining of bands, or chromosome segments, allowing the precise identification of individual chromosomes or parts of chromosomes. Applications include the determination of chromosome rearrangements in malformation syndromes and cancer, the chemistry of chromosome segments, chromosome changes during evolution, and, in conjunction with cell hybridization studies, chromosome mapping.
Nucleic Acid Hybridization
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
Chromosomes, Human, Pair 21
A specific pair of GROUP G CHROMOSOMES of the human chromosome classification.
Inbreeding
The mating of plants or non-human animals which are closely related genetically.
Heterozygote
An individual having different alleles at one or more loci regarding a specific character.
Schizophrenia
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
Multiple Endocrine Neoplasia
A group of autosomal dominant diseases characterized by the combined occurrence of tumors involving two or more ENDOCRINE GLANDS that secrete PEPTIDE HORMONES or AMINES. These neoplasias are often benign but can be malignant. They are classified by the endocrine glands involved and the degree of aggressiveness. The two major forms are MEN1 and MEN2 with gene mutations on CHROMOSOME 11 and CHROMOSOME 10, respectively.
Genetic Techniques
Chromosomal, biochemical, intracellular, and other methods used in the study of genetics.
Muscular Dystrophies
A heterogeneous group of inherited MYOPATHIES, characterized by wasting and weakness of the SKELETAL MUSCLE. They are categorized by the sites of MUSCLE WEAKNESS; AGE OF ONSET; and INHERITANCE PATTERNS.
Models, Statistical
Statistical formulations or analyses which, when applied to data and found to fit the data, are then used to verify the assumptions and parameters used in the analysis. Examples of statistical models are the linear model, binomial model, polynomial model, two-parameter model, etc.
Polyploidy
The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.
Genetic Association Studies
The analysis of a sequence such as a region of a chromosome, a haplotype, a gene, or an allele for its involvement in controlling the phenotype of a specific trait, metabolic pathway, or disease.
Major Histocompatibility Complex
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Molecular Sequence Annotation
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Butterflies
Slender-bodies diurnal insects having large, broad wings often strikingly colored and patterned.
Gene Order
The sequential location of genes on a chromosome.
Karyotyping
Mapping of the KARYOTYPE of a cell.
Polymorphism, Single-Stranded Conformational
Variation in a population's DNA sequence that is detected by determining alterations in the conformation of denatured DNA fragments. Denatured DNA fragments are allowed to renature under conditions that prevent the formation of double-stranded DNA and allow secondary structure to form in single stranded fragments. These fragments are then run through polyacrylamide gels to detect variations in the secondary structure that is manifested as an alteration in migration through the gels.
European Continental Ancestry Group
Individuals whose ancestral origins are in the continent of Europe.
Evolution, Molecular
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
Phylogeny
The relationships of groups of organisms as reflected by their genetic makeup.
Breeding
The production of offspring by selective mating or HYBRIDIZATION, GENETIC in animals or plants.
Neurofibromatosis 1
An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).
Oncorhynchus mykiss
A large stout-bodied, sometimes anadromous, TROUT found in still and flowing waters of the Pacific coast from southern California to Alaska. It has a greenish back, a whitish belly, and pink, red, or lavender stripes on the sides, with usually a sprinkling of black dots. It is highly regarded as a sport and food fish. Its former name was Salmo gairdneri. The sea-run rainbow trouts are often called steelheads. Redband trouts refer to interior populations of rainbows.
Exons
The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.
Repetitive Sequences, Nucleic Acid
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
Family
A social group consisting of parents or parent substitutes and children.
Mice, Inbred Strains
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
Fabaceae
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Biological Evolution
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Selection, Genetic
Differential and non-random reproduction of different genotypes, operating to alter the gene frequencies within a population.
Chromosomes, Artificial, Yeast
Chromosomes in which fragments of exogenous DNA ranging in length up to several hundred kilobase pairs have been cloned into yeast through ligation to vector sequences. These artificial chromosomes are used extensively in molecular biology for the construction of comprehensive genomic libraries of higher organisms.
Probability
The study of chance processes or the relative frequency characterizing a chance process.
Soybeans
An annual legume. The SEEDS of this plant are edible and used to produce a variety of SOY FOODS.
Chromosomes, Bacterial
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.

Linkage and gene localization of hereditary spherocytosis (HS). (1/10869)

Fifteen kindreds with dominant hereditary spherocytosis (HS) were studied. Expansion of the data from a family with an 8/12 translocation provided further evidence that at least one locus for HS is located near the breakpoint of the translocation. Linkage analysis of all families showed a lack of linkage with all marker loci studied except for Gm (IgG). Linkage between Gm and HS was shown to be significant with a maximum lod score of 3.42 at a recombination fraction of 22%. No heterogeneity of the recombination fraction was observed either between sexes or between families. These results are compatible with the hypothesis that HS is not a heterogeneous disorder.  (+info)

Enzymes and reproduction in natural populations of Drosophila euronotus. (2/10869)

Populations of Drosophila euronotus, one from southern Louisiana )3 samples), and one from Missouri (2 samples), were classified for allele frequencies at alkaline phosphatase (APH) and acid phosphatase (ACPH) loci. The two populations differed consistently in allele frequencies at both loci. The APH locus is on the inversion-free X chromosome; the chromosomal locus of the autosomal ACPH is unknown, and could involve inversion polymorphism. Wild females from Missouri and Louisiana populations heterozygous at the APH locus carried more sperm at capture than did the corresponding homozygotes. This heterotic association was significant for the combined samples, and whether it was the result of heterosis at the enzyme locus studied, or due to geographically widespread close linkage with other heterotic loci, it should help to maintain heterozygosity at the APH locus. In a Louisiana collection which included large numbers of sperm-free females, simultaneous homozygosity at both enzyme loci was significantly associated with lack of sperm. It is suggested that the latter association is the result of young heterozygous females achieving sexual maturity earlier than do the double homozygotes. The average effective sperm load for 225 wild females was only 29.4, suggesting the necessity for frequent repeat-mating in nature to maintain female fertility. A comparison of the sex-linked APH genotypes of wild females with those of their daughters indicated that among 295 wild-inseminated females from five populations, 35% had mated more than once, and of this 35%, six females had mated at least three times. Because of ascertainment difficulties, it is clear that the true frequency of multiple-mating in nature must have been much higher than the observed 35%. Laboratory studies indicate that multiple-mating in this species does not involve sperm displacement, possibly due to the small number of sperms transmitted per mating, and the fact that the sperm receptacles are only partially filled by a given mating.  (+info)

Marker effects on reversion of T4rII mutants. (3/10869)

The frequencies of 2-aminopurine- and 5-bromouracil-induced A:T leads to G:C transitions were compared at nonsense sites throughout the rII region of bacteriophage T4. These frequencies are influenced both by adjacent base pairs within the nonsense codons and by extracodonic factors. Following 2AP treatment, they are high in amber (UAG) and lower in opal (UGA) codons than in allelic ochre (UAA) codons. In general, 5BU-induced transitions are more frequent in both amber and opal codons than in the allelic ochre codons. 2AP- and 5BU-induced transition frequencies in the first and third positions of opal codons are correlated with those in the corresponding positions of the allelic ochre codons. Similarly, the frequencies of 2AP-induced transition in the first and second positions of amber codons and their ochre alleles are correlated. However, there is little correlation between the frequencies of 5BU-induced transitions in the first and second positions of allelic amber and ochre codons.  (+info)

Aldosterone excretion rate and blood pressure in essential hypertension are related to polymorphic differences in the aldosterone synthase gene CYP11B2. (4/10869)

Significant correlation of body sodium and potassium with blood pressure (BP) may suggest a role for aldosterone in essential hypertension. In patients with this disease, the ratio of plasma renin to plasma aldosterone may be lower than in control subjects and plasma aldosterone levels may be more sensitive to angiotensin II (Ang II) infusion. Because essential hypertension is partly genetic, it is possible that altered control of aldosterone synthase gene expression or translation may be responsible. We compared the frequency of 2 linked polymorphisms, one in the steroidogenic factor-1 (SF-1) binding site and the other an intronic conversion (IC), in groups of hypertensive and normotensive subjects. In a larger population, the relationship of aldosterone excretion rate to these polymorphisms was also evaluated. In 138 hypertensive subjects, there was a highly significant excess of TT homozygosity (SF-1) over CC homozygosity compared with a group of individually matched normotensive control subjects. The T allele was significantly more frequent than the C allele in the hypertensive group compared with the control group. Similarly, there was a highly significant relative excess of the conversion allele over the "wild-type" allele and of conversion homozygosity over wild-type homozygosity in the hypertensive group compared with the control group. In 486 subjects sampled from the North Glasgow Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) population, SF-1 and IC genotypes were compared with tetrahydroaldosterone excretion rate. Subjects with the SF-1 genotypes TT or TC had significantly higher excretion rates than those with the CC genotype. The T allele was associated with higher excretion rates than the C allele. However, no significant differences were found in excretion rate between subjects of different IC genotype. Urinary aldosterone excretion rate may be a useful intermediate phenotype linking these genotypes to raised BP. However, no causal relationship has yet been established, and it is possible that the polymorphisms may be in linkage with other causative mutations.  (+info)

Familial antiphospholipid antibody syndrome: criteria for disease and evidence for autosomal dominant inheritance. (5/10869)

OBJECTIVE: To develop diagnostic criteria for a familial form of antiphospholipid antibody syndrome (APS), identify families with >1 affected member, examine possible modes of inheritance, and determine linkage to potential candidate genes. METHODS: Family members of probands with primary APS were analyzed for clinical and laboratory abnormalities associated with APS. Families with > or =2 affected members were analyzed by segregation analysis and typed for candidate genetic markers. RESULTS: Seven families were identified. Thirty of 101 family members met diagnostic criteria for APS. Segregation studies rejected both environmental and autosomal recessive models, and the data were best fit by either a dominant or codominant model. Linkage analysis showed independent segregation of APS and several candidate genes. CONCLUSION: Clinical and laboratory criteria are essential to identify the spectrum of disease associated with APS. We believe a set of criteria was developed that can precisely define affected family members with APS. Modeling studies utilizing these criteria strongly support a genetic basis for disease in families with APS and suggest that a susceptibility gene is inherited in an autosomal dominant pattern. However, in these families, APS was not linked with HLA, Fas, or other candidate genes, including beta2-glycoprotein 1, HLA, T cell receptor beta chain, Ig heavy chain, antithrombin III, Fas ligand, factor V, complement factor H, IgK, and Fas.  (+info)

Four new mutations in the erythroid-specific 5-aminolevulinate synthase (ALAS2) gene causing X-linked sideroblastic anemia: increased pyridoxine responsiveness after removal of iron overload by phlebotomy and coinheritance of hereditary hemochromatosis. (6/10869)

X-linked sideroblastic anemia (XLSA) in four unrelated male probands was caused by missense mutations in the erythroid-specific 5-aminolevulinate synthase gene (ALAS2). All were new mutations: T647C, C1283T, G1395A, and C1406T predicting amino acid substitutions Y199H, R411C, R448Q, and R452C. All probands were clinically pyridoxine-responsive. The mutation Y199H was shown to be the first de novo XLSA mutation and occurred in a gamete of the proband's maternal grandfather. There was a significantly higher frequency of coinheritance of the hereditary hemochromatosis (HH) HFE mutant allele C282Y in 18 unrelated XLSA hemizygotes than found in the normal population, indicating a role for coinheritance of HFE alleles in the expression of this disorder. One proband (Y199H) with severe and early iron loading coinherited HH as a C282Y homozygote. The clinical and hematologic histories of two XLSA probands suggest that iron overload suppresses pyridoxine responsiveness. Notably, reversal of the iron overload in the Y199H proband by phlebotomy resulted in higher hemoglobin concentrations during pyridoxine supplementation. The proband with the R452C mutation was symptom-free on occasional phlebotomy and daily pyridoxine. These studies indicate the value of combined phlebotomy and pyridoxine supplementation in the management of XLSA probands in order to prevent a downward spiral of iron toxicity and refractory anemia.  (+info)

Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups. (7/10869)

The locus for the X-borne type of Charcot-Marie-Tooth muscular atrophy is not close to the Xg locus and probably not within direct measurable distance of it.  (+info)

A novel method for determining linkage between DNA sequences: hybridization to paired probe arrays. (8/10869)

Cooperative hybridization has been used to establish physical linkage between two loci on a DNA strand. Linkage was detected by hybridization to a new type of high-density oligonucleotide array. Each synthesis location on the array contains a mixture of two different probe sequences. Each of the two probes can hybridize independently to a different target sequence, but if the two target sequences are physically linked there is a cooperative increase in hybridization yield. The ability to create and control non-linear effects raises a host of possibilities for applications of oligonucleotide array hybridization. The method has been used to assign linkage in 50:50 mixtures of DNA containing single nucleotide polymorphisms (SNPs) separated by 17, 693, 1350 and 2038 bp and to reconstruct haplotypes. Other potential uses include increasing the specificity of hybridization in mutation detection and gene expression monitoring applications, determining SNP haplotypes, characterizing repetitive sequences, such as short tandem repeats, and aiding contig assembly in sequen-cing by hybridization.  (+info)

Meta-analysis of genome-wide linkage studies of asthma and related traits | RESPIRATORY RESEARCH | Full TextMeta-analysis of genome-wide linkage studies of asthma and related traits | RESPIRATORY RESEARCH | Full Text
Asthma and allergy are complex multifactorial disorders, with both genetic and environmental components determining disease expression. The use of molecular genetics holds great promise for the identification of novel drug targets for the treatment of asthma and allergy. Genome-wide linkage studies have identified a number of potential disease susceptibility loci but replication remains inconsistent. The aim of the current study was to complete a meta-analysis of data from genome-wide linkage studies of asthma and related phenotypes and provide inferences about the consistency of results and to identify novel regions for future gene discovery. The rank based genome-scan meta-analysis (GSMA) method was used to combine linkage data for asthma and related traits; bronchial hyper-responsiveness (BHR), allergen positive skin prick test (SPT) and total serum Immunoglobulin E (IgE) from nine Caucasian asthma populations. Significant evidence for susceptibility loci was identified for quantitative traits
https://respiratory-research.biomedcentral.com/articles/10.1186/1465-9921-9-38
Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p...Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p...
TY - JOUR. T1 - Meta-analysis of five genome-wide linkage studies for body mass index reveals significant evidence for linkage to chromosome 8p. AU - Johnson, L.. AU - Luke, A.. AU - Deng, H. W.. AU - Mitchell, B. D.. AU - Comuzzie, A. G.. AU - Cole, S. A.. AU - Blangero, J.. AU - Perola, M.. AU - Teare, M. Dawn. PY - 2005/4. Y1 - 2005/4. N2 - OBJECTIVE: To perform a meta-analysis of genome-wide linkage scans using body mass index (BMI) to identify genetic loci predisposing to obesity. DATA: A total of 13 published genome scans on obesity have used BMI as their primary end point. Five of these 13 groups agreed to provide detailed results from their scans that were required for a meta-analysis. Collectively, these five studies included a total of 2814 individuals from 505 families. METHODS: The results of the five studies were analysed using the GSMA (genome scans meta-analysis) method. RESULTS: The analysis revealed significant evidence for linkage of the quantitative phenotype BMI to 8p (P , ...
https://scholars.uthscsa.edu/en/publications/meta-analysis-of-five-genome-wide-linkage-studies-for-body-mass-i
Microsatellite association mapping of a primary osteoarthritis susceptibility locus on chromosome 6p12.3-q13. - The Kennedy...
OBJECTIVE: To test a high density of microsatellite markers from within a primary osteoarthritis (OA) locus on chromosome 6 for association with OA as a means of narrowing and focusing our search for the susceptibility gene. METHODS: One hundred forty-six families, each with 2 or more women concordant for primary OA (ascertained by total hip replacement), were genotyped for 36 microsatellite markers from within a narrow interval at 6p12.3-q13 which we had previously shown to be linked to OA. Each marker was tested for linkage and for association, the latter by means of the transmission disequilibrium test and by a case-control analysis. RESULTS: The highest 2-point logarithm of odds (LOD) score was 4.8, with 11 markers having LOD scores | or =2.0. Several markers demonstrated evidence of association, in particular, a cluster of markers positioned within or near the functional candidate gene BMP5. CONCLUSION: Our linkage data reinforce the evidence of a major susceptibility locus on chromosome 6. We had
https://www.kennedy.ox.ac.uk/publications/107294
Genetic linkage financial definition of Genetic linkageGenetic linkage financial definition of Genetic linkage
Definition of Genetic linkage in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Genetic linkage? Meaning of Genetic linkage as a finance term. What does Genetic linkage mean in finance?
https://financial-dictionary.thefreedictionary.com/genetic+linkage
Half-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. | GeneticsHalf-tetrad analysis in zebrafish: mapping the ros mutation and the centromere of linkage group I. | Genetics
Analysis of meiotic tetrads is routinely used to determine genetic linkage in various fungi. Here we apply tetrad analysis to the study of genetic linkage in a vertebrate. The half-tetrad genotypes of gynogenetic diploid zebrafish produced by early-pressure (EP) treatment were used to investigate the linkage relationships of two recessive pigment pattern mutations, leopard (leo) and rose (ros). The results showed that ros is tightly linked to its centromere and leo maps 31 cM from its centromere. Analysis of half-tetrads segregating for ros and leo in repulsion revealed no homozygous ros individuals among 32 homozygous leo half-tetrads--i.e., a parental ditype (PD) to nonparental ditype (NPD) ratio of 32:0. This result shows that ros is linked to leo, a mutation previously mapped to Linkage Group I. Investigation of PCR-based DNA polymorphisms on Linkage Group I confirmed the location of ros near the centromere of this linkage group. We propose an efficient, generally useful method to assign new ...
https://www.genetics.org/content/139/4/1727
Sex linkage | Article about sex linkage by The Free DictionarySex linkage | Article about sex linkage by The Free Dictionary
Looking for sex linkage? Find out information about sex linkage. That sex of some species which produces two or more different kinds of gametes that differ in their sex chromosome content Explanation of sex linkage
http://encyclopedia2.thefreedictionary.com/sex+linkage
A genome-wide significant linkage for severe depression on chromosome 3:the depression network study - Lancaster EPrintsA genome-wide significant linkage for severe depression on chromosome 3:the depression network study - Lancaster EPrints
OBJECTIVE: The purpose of this study was to find loci for major depression via linkage analysis of a large sibling pair sample. METHOD: The authors conducted a genome-wide linkage analysis of 839 families consisting of 971 affected sibling pairs with severe recurrent major depression, comprising waves I and II of the Depression Network Study cohort. In addition to examining affected status, linkage analyses in the full data set were performed using diagnoses restricted by impairment severity, and association mapping of hits in a large case-control data set was attempted. RESULTS: The authors identified genome-wide significant linkage to chromosome 3p25-26 when the diagnoses were restricted by severity, which was a maximum LOD score of 4.0 centered at the linkage marker D3S1515. The linkage signal identified was genome-wide significant after correction for the multiple phenotypes tested, although subsequent association mapping of the region in a genome-wide association study of a U.K. depression ...
https://eprints.lancs.ac.uk/id/eprint/79930/?template=browse
Follow-up of Genetic Linkage Findings on Chromosome 16p13: Evidence of Association of N-methyl-D Aspartate Glutamate Receptor...Follow-up of Genetic Linkage Findings on Chromosome 16p13: Evidence of Association of N-methyl-D Aspartate Glutamate Receptor...
Attention deficit hyperactivity disorder (ADHD) is a childhood onset disorder, for which there is good evidence that genetic factors contribute to the aetiology. Recently reported linkage findings suggested evidence of a susceptibility locus on chromosome 16p13 (maximum LOD score of 4.2, P=5 x 10(-6 …
https://pubmed.ncbi.nlm.nih.gov/14966475/
Assessing genotype × environment interaction in linkage mapping using affected sib pairs | BMC Proceedings | Full TextAssessing genotype × environment interaction in linkage mapping using affected sib pairs | BMC Proceedings | Full Text
Rheumatoid arthritis (RA) is a complex disease that involves both environmental and genetic factors. Elucidation of the basic etiologic factors involved in RA is essential for preventing and treating this disease. However, the etiology of RA, like that of other complex diseases, is largely unknown. In the present study, we conducted autosomal multipoint linkage scans using affected sib pairs by incorporating the smoking status into analysis. We divided the affected sib pairs into three subgroups based on smoking status (ever, current, or never). Interactions between the susceptibility genes and smoking could then be assessed through linkage mapping. Results suggested that the genetic effect of chromosome 6p21.2-3 in concordant current smoker pairs was about two-fold greater than that of the concordant non-current smoker pairs or discordant pairs. With incorporation of smoking status, additional regions with evidence of linkage were identified, including chromosomes 4q and 20q; while evidence of linkage
https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-1-S1-S71
Enhanced Linkage Maps From Family-Based Genetics Studies - Full Text View - ClinicalTrials.govEnhanced Linkage Maps From Family-Based Genetics Studies - Full Text View - ClinicalTrials.gov
BACKGROUND:. Meiotic linkage maps are the foundation of both linkage and linkage disequilibrium studies for mapping disease genes. Despite the importance of precise maps, existing genome-wide linkage maps were built using only a small collection of pedigrees, and so have wide confidence intervals surrounding estimates of map distance. Incorrect marker order and map distances can have a profound effect on linkage analyses. Using a sex-averaged map instead of a sex-specific map biases the lod scores upward, markedly increasing the false positive rate. Since it is very costly to follow-up many false-positive results, there is a clear need for more precise and accurate sex-specific genetic maps. Accurate estimates of meiotic map distance cannot be obtained by any means other than by linkage analysis using genotype data.. The study is in response to a Request for Applications entitled NHLBI Innovative Research Grant Program released in July, 2001. The purpose of the initiative is to support new ...
https://clinicaltrials.gov/ct2/show/NCT00049868
Genetic linkage - Linkage mapGenetic linkage - Linkage map
Recombination frequency (θ) is when crossing-over will take place between two loci (or genes) during meiosis. Recombination frequency is a measure of genetic linkage and is used in the creation of a genetic linkage map. A centimorgan (cM) is a unit that describes a recombination frequency of 1%.. During meiosis, chromosomes assort randomly into gametes, such that the segregation of alleles of one gene is independent of alleles of another gene. This is stated in Mendels Second Law and is known as the law of independent assortment. The law of independent assortment always holds true for genes that are located on different chromosomes, but for genes that are on the same chromosome, it does not always hold true.. As an example of independent assortment, consider the crossing of the pure-bred homozygote parental strain with genotype AABB with a different pure-bred strain with genotype aabb. A and a and B and b represent the alleles of genes A and B. Crossing these homozygous parental strains will ...
http://tech1207.blogspot.com/2008/01/genetic-linkage-linkage-map.html
Type 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs | PNASType 2 diabetes: Evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs | PNAS
We analyzed a large group of Finnish type 2 diabetic families and found evidence for linkage to chromosome 20. Three linkage peaks were seen after analyses of diabetes and diabetes-related traits. These linkages were at approximately 0-25 cM, 50-60 cM, and 63-72 cM respectively from the marker D20S103. Although the second and third peaks could be explained by a single susceptibility locus, evidence for linkage on both arms on chromosome 20 argues for the presence of more than one susceptibility locus. As far as we know, we are the first group to show evidence for linkage to the proximal p arm of chromosome 20 in type 2 diabetes. Most of our evidence comes from families with affected sibships greater than two. Ordered subset analyses of our data revealed that a small number of families, with high or low values of important diabetes-related traits, give rise to large lod scores near the three peaks. These analyses provide additional evidence for more than one susceptibility locus on this ...
https://www.pnas.org/content/96/5/2198?ijkey=72d495e58d83a3702d4357794bd499d400661546&keytype2=tf_ipsecsha
A genome scan for serum triglyceride in obese nuclear families<...
TY - JOUR. T1 - A genome scan for serum triglyceride in obese nuclear families. AU - Li, Wei Dong. AU - Dong, Chuanhui. AU - Li, Ding. AU - Garrigan, Cathleen. AU - Price, R. Arlen. PY - 2005/12/1. Y1 - 2005/12/1. N2 - Serum triglyceride (TG) levels are increased in extremely obese individuals, indicating abnormalities in lipid metabolism and insulin resistance. We carried out a genome scan for serum TG in 320 nuclear families segregating extreme obesity and normal weight. Three hundred eighty-two Marshfield microsatellite markers (Screening Set 11) were genotyped. Quantitative linkage analyses were performed using family regression and variance components methods. We found linkage on the 7q36 region [D7S3058, 174 centimorgan (cM), Logarithm of Odds (LOD) = 2.98] for log-transformed TG. We also found suggestive linkages on chromosomes 20 (D20S164, 101 cM, LOD = 2.34), 13 (111 cM, LOD = 2.00), and 9 (104 cM, LOD = 1.90) as well as some weaker trends for chromosomes 1, 3, 5, 10, 12, and 22. In 58 ...
https://miami.pure.elsevier.com/en/publications/a-genome-scan-for-serum-triglyceride-in-obese-nuclear-families
Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and...Genome wide scan in a Flemish inflammatory bowel disease population: support for the IBD4 locus, population heterogeneity, and...
Given the absence of linkage on chromosome 16, and even exclusion on chromosomes 3, 7, and 12 in a smaller Belgian dataset of IBD families,37 a genome wide search in a larger Belgian IBD population was performed to see if other linkages could be identified. Lander and Kruglyak have proposed a classification with thresholds of linkage for genome wide scans.44 Although none of the identified regions in our genome scan meet the Lander and Kruglyak criteria for significant (Lod ,3.6, p = 2×10−5) or suggestive linkage (Lod,2.2, p = 7×10−4), several findings are noteworthy and deserve attention. Firstly, four of the susceptibility regions found in this genome scan coincided with regions found by other investigators. Intriguing is the fact that two of these regions-namely, on chromosomes 4 and 10-overlapped with findings from the European collaborative study.17 This study consisted of 353 affected sibling pairs originating from the UK, the Netherlands, and Germany mainly. The migration waves that ...
http://gut.bmj.com/content/53/7/980
Rabbit polyclonal to GLUT1 - BET-bromodomain inhibition researchRabbit polyclonal to GLUT1 - BET-bromodomain inhibition research
Background It has been suggested that efforts to identify genetic risk markers of autism spectrum disorder (ASD) would benefit from the analysis of more narrowly defined ASD phenotypes. software program MCLINK, a Markov chain Monte Carlo (MCMC) method that allows for multilocus linkage analysis on large extended pedigrees. Results Genome-wide significance was observed for IS at 2q37.1-q37.3 (dominant model heterogeneity lod score (hlod) 3.42) and for RSMA at 15q13.1-q14 (recessive model hlod 3.93). We found some linkage signals that overlapped and others that were not observed in our previous linkage analysis of the ASD phenotype in the same pedigrees, and regions varied in the range of phenotypes with which they were linked. A new finding with respect to Is Apilimod supplier usually was that it is positively associated with IQ if the IS-RSMA correlation is usually statistically controlled. Conclusions The finding that Is usually and Apilimod supplier RSMA are linked to different regions that ...
http://healthandwellnesssource.org/tag/rabbit-polyclonal-to-glut1/
DSLINK: A computer program for gene-centromere linkage analysis in families with a trisomic offspring<...
TY - JOUR. T1 - DSLINK. T2 - A computer program for gene-centromere linkage analysis in families with a trisomic offspring. AU - Halloran, S. L.. AU - Chakravarti, A.. PY - 1987. Y1 - 1987. N2 - Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When centromeric markers are available, linkage analysis between the centromere and any marker locus can be performed in nuclear families having one or more trisomic offspring. Since conventional linkage programs consider only disomic individuals, we have written a FORTRAN computer program, DSLINK, that performs gene-centromere linkage analysis on the basis of information on trisomic and disomic offspring. This program makes it possible to study the relationship between recombination and chromosome segregation.. AB - Trisomic individuals provide information for gene-centromere mapping, since two of the four chromatids in a meiotic tetrad can be recovered. When ...
https://jhu.pure.elsevier.com/en/publications/dslink-a-computer-program-for-gene-centromere-linkage-analysis-in-4
Exploring Positional Candidate Genes: Linkage Conditional on Measured Genotype<...Exploring Positional Candidate Genes: Linkage Conditional on Measured Genotype<...
TY - JOUR. T1 - Exploring Positional Candidate Genes. T2 - Linkage Conditional on Measured Genotype. AU - Almasy, L.. AU - Blangero, J.. N1 - Funding Information: This work was supported in part by NIH Grants MH59490, AA08403, HL70751, HL45522, and GM31575.. PY - 2004/3. Y1 - 2004/3. N2 - Variance component methods for linkage analysis of quantitative traits are now well established and have been applied with great success. Numerous QTLs influencing both normal variation between individuals and biomedically relevant quantitative risk factors have been localized in recent years. These findings have motivated recent methodological developments focused on the next step in the analytical process, moving beyond QTL localization by linkage to identifying specific genes and the functional polymorphisms in them that influence the phenotype of interest. In this paper, we describe one approach to exploring positional candidate genes in a region of linkage, linkage analysis conditional on measured ...
https://scholars.uthscsa.edu/en/publications/exploring-positional-candidate-genes-linkage-conditional-on-measu
Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG<...
TY - JOUR. T1 - Chromosomes 4 and 8 implicated in a genome wide SNP linkage scan of 762 prostate cancer families collected by the ICPCG. AU - Lu, Lingyi. AU - Cancel-Tassin, Geraldine. AU - Valeri, Antoine. AU - Cussenot, Olivier. AU - Lange, Ethan M.. AU - Cooney, Kathleen A.. AU - Farnham, James M.. AU - Camp, Nicola J.. AU - Cannon-Albright, Lisa A.. AU - Tammela, Teuvo L.J.. AU - Schleutker, Johanna. AU - Hoegel, Josef. AU - Herkommer, Kathleen. AU - Maier, Christiane. AU - Vogel, Walther. AU - Wiklund, Fredrik. AU - Emanuelsson, Monica. AU - Grönberg, Henrik. AU - Wiley, Kathleen E.. AU - Isaacs, Sarah D.. AU - Walsh, Patrick C.. AU - Helfand, Brian T.. AU - Kan, Donghui. AU - Catalona, William J.. AU - Stanford, Janet L.. AU - Fitzgerald, Liesel M.. AU - Johanneson, Bo. AU - Deutsch, Kerry. AU - McIntosh, Laura. AU - Ostrander, Elaine A.. AU - Thibodeau, Stephen N.. AU - McDonnell, Shannon K.. AU - Hebbring, Scott. AU - Schaid, Daniel J.. AU - Whittemore, Alice S.. AU - Oakley-Girvan, ...
https://jhu.pure.elsevier.com/en/publications/chromosomes-4-and-8-implicated-in-a-genome-wide-snp-linkage-scan--4
Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13 | Molecular...Pooled genome-wide linkage data on 424 ADHD ASPs suggests genetic heterogeneity and a common risk locus at 5p13 | Molecular...
Genome scan analyses and fine mapping investigations in the UCLA sample support significant linkage in three regions: 6q12 (MLS 3.30), 16p13 (MLS 3.73), and 17p11 (MLS 3.63), while the Utrecht two-stage genome scan supports significant linkage in two regions: 7p13 (MLS 3.04) and 15q15 (MLS 3.54). Both studies had lower linkage signals (1,MLS,3) at multiple locations, but only one region of overlap at 5p13 (UCLA MLS=2.55;6 Utrecht Broad Affection Criteria MLS=1.43 and Narrow Criteria MLS=0.478). In an attempt to better interpret the lack of replication across these two data sets, we pooled genotypic data and re-analyzed the pooled sample in two ways. First, we estimate linkage evidence across the whole genome using the pooled sample and empiric P-values generated by simulations (i.e. generating empiric P-values based on 1000 replicates per chromosome using the exact marker information from the individual scans; for methods, see Ogdie et al.4). For that analysis, we combined the data into a single ...
https://www.nature.com/articles/4001760?error=cookies_not_supported&code=91f741e7-be7b-4994-be11-ad76c9d8ae31
Class 12 -Biology-Genetics-Lec6-Gene Linkage, Crossing Over and Recombinant Frequency - VideoClass 12 -Biology-Genetics-Lec6-Gene Linkage, Crossing Over and Recombinant Frequency - Video
covers knowledge about gene linkage and linkage groups, crossing over with its role in variation and evolution and frequency of variation.. By: sci4you ...
https://www.genetherapy.me/gene-therapy-research/class-12-biology-genetics-lec6-gene-linkage-crossing-over-and-recombinant-frequency-video.php
Linkage of early-onset familial breast cancer to chromosome 17q21 | ScienceLinkage of early-onset familial breast cancer to chromosome 17q21 | Science
Human breast cancer is usually caused by genetic alterations of somatic cells of the breast, but occasionally, susceptibility to the disease is inherited. Mapping the genes responsible for inherited breast cancer may also allow the identification of early lesions that are critical for the development of breast cancer in the general population. Chromosome 17q21 appears to be the locale of a gene for inherited susceptibility to breast cancer in families with early-onset disease. Genetic analysis yields a lod score (logarithm of the likelihood ratio for linkage) of 5.98 for linkage of breast cancer susceptibility to D17S74 in early-onset families and negative lod scores in families with late-onset disease. Likelihood ratios in favor of linkage heterogeneity among families ranged between 2000:1 and greater than 10(6):1 on the basis of multipoint analysis of four loci in the region. ...
https://science.sciencemag.org/content/250/4988/1684?ijkey=4b15c1a847e1efe5157d76945d48a8475fc39560&keytype2=tf_ipsecsha
MLIP: using multiple processors to compute the posterior probability of linkageMLIP: using multiple processors to compute the posterior probability of linkage
Background: Localization of complex traits by genetic linkage analysis may involve exploration of a vast multidimensional parameter space. The posterior probability of linkage (PPL), a class of statistics for complex trait genetic mapping in humans, is designed to model the trait model complexity represented by the multidimensional parameter space in a mathematically rigorous fashion. However, the method requires the evaluation of integrals with no functional form, making it difficult to compute, and thus further test, develop and apply. This paper describes MLIP, a multiprocessor two-point genetic linkage analysis system that supports statistical calculations, such as the PPL, based on the full parameter space implicit in the linkage likelihood. Results: The fundamental question we address here is whether the use of additional processors effectively reduces total computation time for a PPL calculation. We use a variety of data - both simulated and real - to explore the question how close can ...
https://kb.osu.edu/handle/1811/47543
Development and applications of a molecular genetic linkage map of the mouse genomeDevelopment and applications of a molecular genetic linkage map of the mouse genome
Interspecific mouse backcrosses provide almost limitless genetic variation for gene mapping. We have used interspecific backcrosses to develop the first comprehensive molecular genetic linkage map of the mouse genome. More than 600 loci have been positioned on the map; the current average map resolu …
https://pubmed.ncbi.nlm.nih.gov/2068781/?dopt=Abstract
Mutations in FN1 cause glomerulopathy with fibronectin deposits | PNASMutations in FN1 cause glomerulopathy with fibronectin deposits | PNAS
We performed haplotype analysis in pedigree F233 by using 10 polymorphic microsatellite DNA markers spanning 22 Mb along the RCA cluster at the 1q32 locus (6) (see SI Text and SI Fig. 4).. Seventeen subjects were haplotyped. Segregation of GFND in this family was consistent with autosomal dominant inheritance and age-related penetrance. Because the disease has progressive manifestations, the absence of the disease could not be determined with certainty in the four healthy subjects of the third generation (all ,35 years of age). Data were first evaluated on the basis of affecteds-only strategy. None of the haplotypes cosegregated with GFND and linkage analysis by GENEHUNTER software gave a multipoint logarithm of odds (lod) score less than −2 throughout the chromosomal area. In further analyses, liability classes were assigned according to age at examination, as described in Methods. Results of two-point and multipoint linkage analyses confirmed the exclusion of 1q32 as disease locus in this ...
https://www.pnas.org/content/105/7/2538.long
Whole Brain and Regional Hyperintense White Matter Volume and Blood Pressure | StrokeWhole Brain and Regional Hyperintense White Matter Volume and Blood Pressure | Stroke
Our study in healthy Mexican Americans individuals aimed to replicate a finding of shared genetic loci between HWM and quantitative BP traits, previously reported by Turner et al4 in a study of hypertensive sibships. We performed these analyses in a cohort of well-characterized population of Mexican Americans. Additional, post hoc analyses were performed in a cohort that excluded subjects taking antihypertensive medications. The genetic linkage analyses in both cohorts identified the same regions of significant and suggestive linkage and these loci overlapped with several loci reported by Turner and colleagues and with several loci previously identified by the univariate linkage analyses of BP, triglyceride levels, and atherosclerosis traits performed by this and other groups. The highest linkage value (LOD=3.82/3.62 full versus normotensive cohorts) was observed for the bivariate linkage analysis of WB HWM volume and PP. This locus (chromosome 1q24) was also significant in the bivariate ...
http://stroke.ahajournals.org/content/41/10/2137
parallel motion linkage application
engines was called the parallel motion linkage, a development of Watts linkage, but using the same principle. Linkages found in a sewing machine. This paper describes the procedure of optimal synthesis of a four-bar linkage, with the application of genetic algorithm and combination of cognates of the optimal mechanism to achieve a Watts six-bar linkage. The linkage is connected to a support structure which guides its movement. Optimization of Watts Six-bar Linkage to Generate Straight and Parallel Leg Motion.pdf Journal of Humanoids, Vol. The photograph above shows various linkages and levers in a typical sewing machine. One of the problems was the construction of a linkage that converts a rotary motion into an This linkage is comprised of three straight links, connected by two axle joints. 1, (2008) ISSN 1006-7290, pp. The This linkage is commonly used in suspension systems, as shown below. Technically classed as a four-bar linkage, it can be rotated through 360° without changing its ...
http://motservicecentres.com/8xkoc6ks/971abf-parallel-motion-linkage-application
Data for Genetic Analysis Workshop (GAW) 15, Problem 1: genetics of gene expression variation in humans | BMC Proceedings |...Data for Genetic Analysis Workshop (GAW) 15, Problem 1: genetics of gene expression variation in humans | BMC Proceedings |...
The data provided to Genetic Analysis Workshop 15 (GAW15) were of several sorts. The basic collection was of data from large families, specifically 14 three-generation Centre dEtude du Polymorphisme Humain (CEPH) Utah families (approximately 8 offspring per sibship and 14 individuals per family). The CEPH Utah families are the most uniform of the three-generation CEPH families (parents and grandparents are available) and cells are available for all four grandparents. The data provided were from 14 of these. In addition, gene expression data were provided from 30 HapMap trios: these are grandparent-parent trios that are partly included among those in the 14 families, plus approximately 12 additional grandparent-parent trios of CEPH Utah individuals. The 30 trios are also part of the International HapMap Project. The data included pedigree files with information on the structure of each family.. ...
https://bmcproc.biomedcentral.com/articles/10.1186/1753-6561-1-S1-S2
QIMR Genetic Epidemiology Laboratory Home Page
Over 30 genomic regions show linkage to asthma traits. Six asthma genes have been cloned, but the putative loci in many linked regions have not been identified. To search for asthma susceptibility loci, we performed genomewide univariate linkage analyses of seven asthma traits, using 202 Australian families ascertained through a twin proband. House-dust mite sensitivity (Dpter) exceeded the empirical threshold for significant linkage at 102 cM on chromosome 20q13, near marker D20S173 (empirical pointwise P = .00001 and genomewide P = .005, both uncorrected for multiple-trait testing). Atopy, bronchial hyperresponsiveness (BHR), and forced expiratory volume in 1 s (FEV1) were also linked to this region. In addition, 16 regions were linked to at least one trait at the suggestive level, including 12q24, which has consistently shown linkage to asthma traits in other studies. Some regions were expected to be false-positives arising from multiple-trait testing. To address this, we developed a new ...
https://genepi.qimr.edu.au/general/publicationsfulllisting.cgi?pmid=16380917
JCI - Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disordersJCI - Mutations in sodium-channel gene SCN9A cause a spectrum of human genetic pain disorders
A genome-wide linkage study in a large kindred of individuals with PE detected strong evidence for linkage with polymorphic markers on chromosome 2q (35). Haplotype analysis in four additional families confirmed the locus, and recombinant events defined the critical interval to 7.94 cM. Subsequent analysis of another family allowed narrowing of the region to 5.98 cM (3). This interval contains five genes encoding sodium-channel α subunits. After confirming the presence of this genetic interval in two affected families, two candidate genes, including SCN9A, were tested (3). A missense mutation (L858H) in SCN9A was identified that segregated with the disease in a three-generation Chinese family while an I848T mutation was present in a single sporadic case. Both mutations affected conserved residues in the pore-forming α subunit of the Nav1.7 channel, and multiple alignment indicated that the affected amino acids are conserved in sodium channels. Subsequent independent studies confirmed these ...
https://www.jci.org/articles/view/33297
BIONET.MOLBIO.GENE-LINKAGE.FAQBIONET.MOLBIO.GENE-LINKAGE.FAQ
BIONET.MOLBIO.GENE-LINKAGE FREQUENTLY ASKED QUESTIONS (FAQ) AS OF 1997/10/27 1.0) FAQ ADMINISTRATIVE INFORMATION [1995/05/18] 1.1) Where can I obtain and/or access the bionet.molbio.gene-linkage FAQ? [1995/03/01] 1.2) Who created the bionet.molbio.gene-linkage FAQ? [1995/03/01] 1.3) How can I help improve this FAQ? [1995/03/01] 1.4) Contributors to this FAQ. [1995/09/09] 1.5) When was the FAQ last updated? [1996/04/28] 2.0) INFORMATION RESOURCES 2.1) What anonymous FTP sites have programs/utilities useful for linkage analysis? [1995/03/01] 2.2) What books are helpful when learning about linkage analysis? [1995/03/01] 2.3) What WWW sites have useful linkage information? [1996/01/02] 2.4) What gopher sites have useful linkage information? [1995/03/01] 2.5) What linkage centers make information and assistance available to researchers? [1995/12/11] 2.6) What journals are useful for linkage analysis? [1995/06/02] 2.7) What courses are offered in linkage analysis? [1995/09/09] 3.0) GENE-LINKAGE ...
http://www.bio.net/bionet/mm/gen-link/1997-December/001393.html
BIONET.MOLBIO.GENE-LINKAGE.FAQBIONET.MOLBIO.GENE-LINKAGE.FAQ
BIONET.MOLBIO.GENE-LINKAGE FREQUENTLY ASKED QUESTIONS (FAQ) AS OF 1995/12/11 1.0) FAQ ADMINISTRATIVE INFORMATION [1995/05/18] 1.1) Where can I obtain and/or access the bionet.molbio.gene-linkage FAQ? [1995/03/01] 1.2) Who created the bionet.molbio.gene-linkage FAQ? [1995/03/01] 1.3) How can I help improve this FAQ? [1995/03/01] 1.4) Contributors to this FAQ. [1995/09/09] 1.5) When was the FAQ last updated? [1995/09/14] 2.0) INFORMATION RESOURCES 2.1) What anonymous FTP sites have programs/utilities useful for linkage analysis? [1995/03/01] 2.2) What books are helpful when learning about linkage analysis? [1995/03/01] 2.3) What WWW sites have useful linkage information? [1996/01/02] 2.4) What gopher sites have useful linkage information? [1995/03/01] 2.5) What linkage centers make information and assistance available to researchers? [1995/12/11] 2.6) What journals are useful for linkage analysis? [1995/06/02] 2.7) What courses are offered in linkage analysis? [1995/09/09] 3.0) GENE-LINKAGE ...
http://www.bio.net/bionet/mm/gen-link/1996-January/000912.html
SEX LINKAGE Characters which are associate more with one gender © 2007 Paul Billiet ODWSODWS. - ppt downloadSEX LINKAGE Characters which are associate more with one gender © 2007 Paul Billiet ODWSODWS. - ppt download
Sex linkage explained Thomas Hunt Morgan in The Fly Room! (Columbia University 1910) Fruit Flies (Drosophila melanogaster) © 2007 Paul Billiet ODWSODWS
http://slideplayer.com/slide/3581488/
Plus itPlus it
The potential contribution of maturity-onset diabetes of the young (MODY) genes to NIDDM susceptibility in African-American and Caucasian NIDDM-affected sibling pairs with a history of adult-onset diabetic nephropathy has been evaluated. Evidence for linkage to NIDDM was found with polymorphic loci that map to the long arms of human chromosomes 20 and 12 in regions containing the MODY1 and MODY3 genes. Nonparametric analysis of chromosome 20 inheritance data collected with the MODYl-linked marker D20S197 provides evidence forlinkage to NIDDM with a P value of 0.005 in Caucasian sib pairs using affected sibpair (ASP) analyses. Nonparametric analysis of chromosome 12 inheritance data collected with the MODY3-linked markers D12S349 and D12S86 provides evidence for linkage to NIDDM with P values of 0.04 and 0.006, respectively, in Caucasian sib pairs using similar analyses. No evidence for linkage of MODY1 and MODY3 markers to NIDDM in African-American sib pairs was observed. In addition, no ...
http://diabetes.diabetesjournals.org/content/46/5/882
Linkage MapLinkage Map
A linkage map is a chromosome map of a species that demonstrates the position of its known genes or markers with respect to each other, as opposed to as particular physical focuses on each chromosome.A Linkage map is unique in relation to quality map. Thomas Hunt Morgan watched that the measure of traverse between connected genes is distinctive. It gives hybrid recurrence shows the separation isolating genes on the chromosome. Morgans understudy Alfred Sturtevant built up the primary hereditary -map, additionally called a linkage map.. Sturtevant suggested that the more prominent the separation between connected genes, the more noteworthy the possibility of traverse between non-sister chromatids. On the off chance that number of recombinant is measured, at that point the separation between the genes can be measured. This separation is known as a hereditary map unit (m.u.), or a centimorgan. It is characterized as the separation between genes for which one result of meiosis in 100 is ...
http://botanystudies.com/linkage-map/
Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.well.ox.ac.uk/publications/234864
Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q...Putative association signals identified through high-density LD mapping of the replicated T2D linkage region on chromosome 1q...
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.rdm.ox.ac.uk/publications/234864/
Biology-Online • View topic - Genes in the same linkage group are inherited together?Biology-Online • View topic - Genes in the same linkage group are inherited together?
When you have allele frequency data of a particular gene and know which genes are in the same linkage group and want to know if they are under the same or similar environmental selections, would you say that the gene of interest is in LD with gene C and they may be under the same selection even if they are 140cM away (*allele frequency of gene C is not known)? If its too far away from each other to come to a valid evolutionary inference, what is a maximum map distance (cM) where you would confidently say the genes are under the same selection? If there is any paper on this topic, please let me know ...
http://www.biology-online.org/biology-forum/about31951.html?p=153852&hilit=map
Genes in the same linkage group are inherited together? - Biology-OnlineGenes in the same linkage group are inherited together? - Biology-Online
When you have allele frequency data of a particular gene and know which genes are in the same linkage group and want to know if they are under the same or similar environmental selections, would you say that the gene of interest is in LD with gene C and they may be under the same selection even if they are 140cM away (*allele frequency of gene C is not known)? If its too far away from each other to come to a valid evolutionary inference, what is a maximum map distance (cM) where you would confidently say the genes are under the same selection? If there is any paper on this topic, please let me know ...
https://www.biology-online.org/biology-forum/viewtopic.php?t=31951&p=153816&hilit=map
Embryological effects of a minute deficiency in linkage group II of the mouse | DevelopmentEmbryological effects of a minute deficiency in linkage group II of the mouse | Development
When DArcy Wentworth Thompsons On Growth and Form was published 100 years ago, it raised the question of how biological forms arise during development and across evolution. In light of the advances in molecular and cellular biology since then, a succinct modern view of the question states: how do genes encode geometry? Our new special issue is packed with articles that use mathematical and physical approaches to gain insights into cell and tissue patterning, morphogenesis and dynamics, and that provide a physical framework to capture these processes operating across scales.. Read the Editorial by guest editors Thomas Lecuit and L. Mahadevan, as they provide a perspective on the influence of DArcy Thompsons work and an overview of the articles in this issue.. ...
http://dev.biologists.org/content/27/1/147
Chromosome Behavior and Gene Linkage - BIOL110F2014 - Confluence
Introduction and Goals Previously we examined the relationship between gene segregation and meiosis. As you should now know, Mendel was able to infer independent assortment between different genes because they were located on different chromosomes (each o
https://wikispaces.psu.edu/display/biology110/Chromosome+Behavior+and+Gene+Linkage
ESP Timeline: History of Technology vs Genetics, Development, and Evolution (1950-1959)ESP Timeline: History of Technology vs Genetics, Development, and Evolution (1950-1959)
F. H. C. Crick suggests that during protein formation the amino acid is carried to the template by an adaptor molecule containing nucleotides and that the adaptor is the part that actually fits on the RNA template. Crick thus predicts the discovery of transfer RNA. F. Jacob and E. L. Wollman demonstrate that the single linkage group of E. coli is circular and suggest that the different linkage groups found in different Hfr strains result from the insertion at different points of a factor in the circular linkage group that determines the rupture of the circle. M. Meselson and F. W. Stahl use the density gradient equilibrium centrifugation technique to demonstrate the semiconservative distribution of density label during DNA replication in E. coli. ...
http://v3r.esp.org/timeline/TEC-vs-GEV_1950-1959.html
Genomewide linkage analysis of age of onset of Huntingtons disease - Oxford Neuroscience
We use cookies to ensure that we give you the best experience on our website. If you click Continue well assume that you are happy to receive all cookies and you wont see this message again. Click Find out more for information on how to change your cookie settings ...
https://www.neuroscience.ox.ac.uk/publications/114758
Difference between revisions of BISC219/F13: Gene Linkage - OpenWetWareDifference between revisions of BISC219/F13: Gene Linkage - OpenWetWare
To start a mating, you will place 4 to 5 young adult (or L4) males on a plate with 4 young adult (or L4) hermaphrodites. We will use plates seeded with a very small drop of OP50 bacteria for our crosses. These seeded plates have been prepared for you by our hard working lab specialists. If you were working as an investigator in a worm lab, you would be doing this preparatory work yourself, including growing the bacteria to be used as worm food, pouring the agar into sterile plates, and seeding those plates with the bacteria. Yes, you should appreciate that this has been done for you! When setting up a mating, it is important to use only a small central area of the plate. Doing so helps our worms find each other quickly and helps insure a successful mating of the parental generation. In the F1 progeny, any self-cross progeny produced by the parental hermaphrodite must be distinguished from outcross progeny. Generally, the hermaphrodite is homozygous for a visible marker and the progeny from ...
https://openwetware.org/wiki/?title=BISC219/F13:_Gene_Linkage&diff=717788&oldid=717786
Collection of Clinical and Epidemiological Data for Genetic Linkage and Association Studies - Current ProtocolsCollection of Clinical and Epidemiological Data for Genetic Linkage and Association Studies - Current Protocols
Modern gene‐mapping can include linkage studies, which correlate the presence of disease to broad genomic regions in either small or large family units, and association studies, which can narrow the location of a disease‐predisposing trait to a single gene using either case‐control or family data
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-hg0101.html?quicktabs_cp=abstract
Agro-Ecosystem-wise Status of Technological Interventions Implemented under Institution-Village Linkage Programme (IVLP) in...Agro-Ecosystem-wise Status of Technological Interventions Implemented under Institution-Village Linkage Programme (IVLP) in...
Agro-Ecosystem-wise Status of Technological Interventions Implemented under Institution-Village Linkage Programme (IVLP) in India (2003-2004 ...
https://www.indiastat.com/table/agriculture-data/2/agricultural-education/9963/331271/data.aspx
Genetics: Complex Inheritance, Sex Linkage, X-Inactivation - ppt video online downloadGenetics: Complex Inheritance, Sex Linkage, X-Inactivation - ppt video online download
Incomplete Dominance Heterozygous phenotype is a blend of the 2 homozygous phenotypes Ex. Red flower crossed with white flower  heterozygous flower is pink
http://slideplayer.com/slide/3797904/
Plus itPlus it
In this study, conducted on a random sample of individuals from the isolated population of Campora, we detected a genome-wide significant linkage between BMI and a new locus on chr1q24. Interestingly, this linkage is also detected when focusing on obesity, and it is replicated for both BMI and obesity in the neighboring village of Gioi. However, in these three latter analyses, the linkage is located 7.7 cM away from the initial signal, at a position where no linkage is observed on the first BMI analysis. Whether this suggests the implication of two different loci remains an open question. Following Göring et al. (32), who demonstrated that the chromosomal position and genotype-phenotype relationship of a locus cannot both be estimated reliably by use of a single data set of current realistic size in linkage analysis, our results may well be generated by a single locus. We believe that having significant replication P values and detecting a linkage with obesity in Campora at the same marker as ...
http://diabetes.diabetesjournals.org/content/57/3/783
Detecting Gene‐Gene Interaction in Linkage Analysis - Current ProtocolsDetecting Gene‐Gene Interaction in Linkage Analysis - Current Protocols
Linkage analysis has been very successful in identifying genes for many Mendelian diseases, but has not enjoyed the same level of success for complex diseases
http://www.currentprotocols.com/WileyCDA/CPUnit/refId-hg0115.html?quicktabs_cp=toc
Linkage Analysis In Psychiatric DisordersLinkage Analysis In Psychiatric Disorders
Annual Review of Genomics and Human Genetics September 2002, Vol. 3, pp. 371-413 (doi:10.1146/annurev.genom.3.022502.103141) First published online as a Review in Advance on June 4, 2002 LINKAGE ANALYSIS IN PSYCHIATRIC DISORDERS: The Emerging Picture Pamela Sklar
https://forums.skadi.net/threads/9252-Linkage-Analysis-In-Psychiatric-Disorders?s=690d886b41d3965482112af0a1687e15
Construction of a consensus linkage map for red clover (Trifolium pratenseL.) | BMC Plant Biology | Full TextConstruction of a consensus linkage map for red clover (Trifolium pratenseL.) | BMC Plant Biology | Full Text
Red clover (Trifolium pratense L.) is a major forage legume that has a strong self-incompatibility system and exhibits high genetic diversity within populations. For several crop species, integrated consensus linkage maps that combine information from multiple mapping populations have been developed. For red clover, three genetic linkage maps have been published, but the information in these existing maps has not been integrated. A consensus linkage map was constructed using six mapping populations originating from eight parental accessions. Three of the six mapping populations were established for this study. The integrated red clover map was composed of 1804 loci, including 1414 microsatellite loci, 181 amplified fragment length polymorphism (AFLP) loci and 204 restriction fragment length polymorphism (RFLP) loci, in seven linkage groups. The average distance between loci and the total length of the consensus map were 0.46 cM and 836.6 cM, respectively. The locus order on the consensus map correlated
https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-9-57
The Blood Pressure Program Reviews - The Bloodpressure Program
the blood pressure program reviews, the blood pressure program, the blood pressure exercise program, the blood pressure solution program, the right fit blood pressure program
https://ubec2015.com/the-bloodpressure-program
The High Blood Pressure Program Review - Easiest Way To Lower Your Blood Pressure Naturally!!The High Blood Pressure Program Review - Easiest Way To Lower Your Blood Pressure Naturally!!
The High Blood Pressure Program Review: What is The High Blood Pressure Program? Read this review to reveal the truth behind The High Blood Pressure Program Ingredients!!! Try a worth now!!!
https://consumerscomment.com/the-high-blood-pressure-program-review/
Linkage Analysis of Affective Disorder Using DNA Markers on Chromosomes 11 and X<...
TY - JOUR. T1 - Linkage Analysis of Affective Disorder Using DNA Markers on Chromosomes 11 and X. AU - Nanko, Shinichiro. AU - Kobayashi, Masaru. AU - Gamou, Shinobu. AU - Kudoh, Jun. AU - Shimizu, Nobuyoshi. AU - Takazawa, Noboru. AU - Kazamatsuri, Hajime. AU - Furusho, Toshiyuki. PY - 1991/3. Y1 - 1991/3. N2 - Abstract: We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c‐Ha‐ras‐1 oncogene and the insulin gene on chromosome 11, or hypoxanthhte phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the markers on chromosomes 11 and X was ruled out with the assumption of no recombination.. AB - Abstract: We have investigated two pedigrees in an attempt to detect the putative linkages between affective disorder and c‐Ha‐ras‐1 oncogene and the insulin gene on chromosome 11, or hypoxanthhte phosphoribosyltransferase (HPRT) on X chromosome. The linkage between affective disorders and the ...
https://keio.pure.elsevier.com/en/publications/linkage-analysis-of-affective-disorder-using-dna-markers-on-chrom
Support for schizophrenia susceptibility locus on chromosome 2q detected in a Swedish isolate using a dense map of...Support for schizophrenia susceptibility locus on chromosome 2q detected in a Swedish isolate using a dense map of...
Extended pedigrees are not only very useful to identify disease genes for rare Mendelian conditions, but they may also help unravel the genetics of complex diseases such as schizophrenia. In this study we performed genome-wide multipoint non-parametric linkage (NPL) score calculations using 825 microsatellites and 5,366 single nucleotide polymorphisms (SNPs), respectively, and searched for haplotypes shared by affected individuals, in three multiplex families including 29 genotyped affected individuals which in total contains 49 relative pairs useful for linkage studies. The most consistent results for microsatellites and SNPs were observed on 2q12.3-q14.1 (NPL scores 2.0, empirical P-value 0.009). However, the overall highest NPL score was observed on chromosome 2q33.3 using SNPs (NPL score 2.2, empirical P-value 0.007). Other chromosomal regions were detected on 5q15-q22.1, with microsatellites (NPL scores 1.7, empirical P-value 0.021) and with SNPs (NPL scores 2.0, empirical P-value 0.010) ...
http://uu.diva-portal.org/smash/record.jsf?pid=diva2:217066
Hitchhikers Guide to the Galaxy on Linkage disequilibrium
In population genetics, linkage disequilibrium is the non-random association of alleles at different loci in a given population. Loci are said to be in linkage disequilibrium when the frequency of association of their different alleles is higher or lower than what would be expected if the loci were independent and associated randomly.[1]. Linkage disequilibrium is influenced by many factors, including selection, the rate of recombination, the rate of mutation, genetic drift, the system of mating, population structure, and genetic linkage. As a result, the pattern of linkage disequilibrium in a genome is a powerful signal of the population genetic processes that are structuring it.. In spite of its name, linkage disequilibrium may exist between alleles at different loci without any genetic linkage between them and independently of whether or not allele frequencies are in equilibrium (not changing with time).[1] Furthermore, linkage disequilibrium is sometimes referred to as gametic phase ...
http://hitchhikersgui.de/Linkage_disequilibrium
A genome-wide scan for loci affecting normal adult height in the Framingham Heart StudyA genome-wide scan for loci affecting normal adult height in the Framingham Heart Study
Objective: To map loci influencing normal adult height in 335 families from the Framingham Heart Study. Methods: We analyzed data consisting of 1,702 genotyped individuals who have been followed over time. The first height measurement for individuals between the ages 20-55 years was analyzed in a genome-wide scan using variance component linkage analysis. Sex, age, and cohort effects were removed before analysis. Results: Two regions (18pter-p11, 22q11.2) with multipoint LOD scores >1.0 (-log p values >2.0) were detected: we obtained LOD scores of 1.38 at D18S1364, and of 1.10 at D22S345. Analysis of height as a sex-limited phenotype revealed a peak in the 9p21 region near D9S319 with a maximum LOD score of 1.65 (-log p value >3.0) when only male height phenotypes were used. When only female phenotypes were used, a peak with a maximum LOD score of 1.85 (-log p value of 2.70) was observed in the 11q25-qter region near D11S2359. Conclusions: Our region of interest on chromosome 9 has been ...
https://scholars.uab.edu/display/pub2143028
Evidence for asthma susceptibility genes on chromosome 11 in an African-American population<...
TY - JOUR. T1 - Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. AU - Huang, Shau Ku. AU - Mathias, Rasika A.. AU - Ehrlich, Eva. AU - Plunkett, Beverly. AU - Liu, Xin. AU - Cutting, Garry R.. AU - Wang, Xin Jing. AU - Li, Xiao Dong. AU - Togias, Alkis. AU - Barnes, Kathleen C.. AU - Malveaux, Floyd. AU - Rich, Stephen. AU - Mellen, Beverly. AU - Lange, Ethan. AU - Beaty, Terri H.. PY - 2003/7/1. Y1 - 2003/7/1. N2 - Initial genome-wide scan data provided suggestive evidence for linkage of the asthma phenotype in African-American (AA), but not Caucasian, families to chromosome 11q markers (peak at D11S1985; LOD=2). To refine this region, mapping analysis of 91 AA families (51 multiplex families and 40 asthmatic case-parent trios) was performed with an additional 17 markers flanking the initial peak linkage marker. Multipoint analyses of the 51 multiplex families yielded significant evidence of linkage with a peak non-parametric linkage score of 4.38 at ...
https://tmu.pure.elsevier.com/en/publications/evidence-for-asthma-susceptibility-genes-on-chromosome-11-in-an-a
Leicester Research Archive: Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension.
It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a novel approach to uncover significant gene-gene interactions in a systematic two-dimensional (2D) genome-scan of essential hypertension. The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the British Genetics of HyperTension study. Extensive simulations were used to establish significance thresholds in the context of 2D genome-scans. Our analyses found significant and suggestive evidence for loci on chromosomes 5, 9, 11, 15, 16 and 19, which influence hypertension when gene-gene interactions are taken into account (5q13.1 and 11q22.1, two-locus lod score=5.72; 5q13.1 and 19q12, two-locus lod score=5.35; 9q22.3 and 15q12, two-locus lod score=4.80; 16p12.3 and 16q23.1, two-locus lod score=4.50). For each significant and suggestive pairwise interaction, the two-locus genetic ...
https://lra.le.ac.uk/handle/2381/17671
A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35 | Garvan Institute of...A transcript map encompassing a susceptibility locus for bipolar affective disorder on chromosome 4q35 | Garvan Institute of...
Bipolar affective disorder is one of the most common mental illnesses with a population prevalence of approximately 1%. The disorder is genetically complex, with an increasing number of loci being implicated through genetic linkage studies. However, the specific genetic variations and molecules involved in bipolar susceptibility and pathogenesis are yet to be identified. Genetic linkage analysis has identified a bipolar disorder susceptibility locus on chromosome 4q35, and the interval harbouring this susceptibility gene has been narrowed to a size that is amenable to positional cloning. We have used the resources of the Human Genome Project (HGP) and Celera Genomics to identify overlapping sequenced BAC clones and sequence contigs that represent the region implicated by linkage analysis. A combination of bioinformatic tools and laboratory techniques have been applied to annotate this DNA sequence data and establish a comprehensive transcript map that spans approximately 5.5 Mb. This map encompasses the
https://www.garvan.org.au/research/publications/1530
No evidence of linkage between the transforming growth factor-alpha gene in families with apparently autosomal dominant...
Eight families have been identified with cleft lip, with or without cleft palate (CL/P), inherited in an apparently autosomal dominant manner. Transforming growth factor-alpha (TGFA) has been tested as a candidate gene for clefting in these families. Negative lod scores were generated in an autosomal dominant model with 80% penetrance (Z = -3.152 at theta = 0.05 and Z = -2.49 at theta = 0.05 with only affected subjects scored). After testing with a reduced penetrance of 28%, less negative lod scores were generated (Z = -0.157 at theta = 0.00), but there was still no evidence of linkage. An autosomal recessive model with a penetrance of 35% was also tested. Regardless of the model used there was little evidence of linkage between TGFA and the CL/P phenotype, which is in contrast to the previously published findings of an association between TGFA and CL/P in unrelated subjects. ...
https://www.meta.org/papers/no-evidence-of-linkage-between-the-transforming/1352355
Genetic linkage - WikipediaGenetic linkage - Wikipedia
Recombination frequency is a measure of genetic linkage and is used in the creation of a genetic linkage map. Recombination frequency (θ) is the frequency with which a single chromosomal crossover will take place between two genes during meiosis. A centimorgan (cM) is a unit that describes a recombination frequency of 1%. In this way we can measure the genetic distance between two loci, based upon their recombination frequency. This is a good estimate of the real distance. Double crossovers would turn into no recombination. In this case we cannot tell if crossovers took place. If the loci were analysing are very close (less than 7 cM) a double crossover is very unlikely. When distances become higher, the likelihood of a double crossover increases. As the likelihood of a double crossover increases we systematically underestimate the genetic distance between two loci. During meiosis, chromosomes assort randomly into gametes, such that the segregation of alleles of one gene is independent of ...
https://en.m.wikipedia.org/wiki/Gene_linkage
Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic...Multiple QTLs influencing triglyceride and HDL and total cholesterol levels identified in families with atherogenic...
We conducted a genome-wide scan using variance components linkage analysis to localize quantitative-trait loci (QTLs) influencing triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol, and total cholesterol (TC) levels in 3,071 subjects from 459 families with atherogenic dyslipidemia. The most significant evidence for linkage to TG levels was found in a subset of Turkish families at 11q22 [logarithm of the odds ratio (LOD) = 3.34] and at 17q12 (LOD = 3.44). We performed sequential oligogenic linkage analysis to examine whether multiple QTLs jointly influence TG levels in the Turkish families. These analyses revealed loci at 20q13 that showed strong epistatic effects with 11q22 (conditional LOD = 3.15) and at 7q36 that showed strong epistatic effects with 17q12 (conditional LOD = 3.21). We also found linkage on the 8p21 region for TG in the entire group of families (LOD = 3.08). For HDL-C levels, evidence of linkage was identified on chromosome 15 in ...
http://researchrepository.murdoch.edu.au/id/eprint/21580/
Analysis of Human Genetic Linkage - Jurg Ott - Google BooksAnalysis of Human Genetic Linkage - Jurg Ott - Google Books
The first and still the only book of its kind, this volume offers a concise introduction to human genetic linkage analysis and gene mapping. Jurg Ott provides mathematical and statistical foundations of linkage analysis for researchers and practitioners, as well as practical comments on available computer programs and websites. Each chapter ends with a set of problems, whose solutions are found at the end of the book.New to this edition is a chapter on complex traits, such as diabetes, some cancers, and psychiatric conditions. Also new is an overview of nonparametric approaches to linkage and association analysis. A chapter on two-locus inheritance introduces the reader to many of the intricate aspects of complex traits. Although the books primary audience is in the field of genetics, physicians and others without sophisticated training in genetics can understand and apply the principles and techniques discussed.
https://books.google.com/books?id=plqENXLNAN0C&dq=related:LCCN74647139&source=gbs_citations_module_r&cad=6
Published ArticlesPublished Articles
Abstract: A previous linkage study provided evidence for a prostate cancer-susceptibility locus at 1q24-25. Subsequent reports in additional collections of families have yielded conflicting results. In addition, evidence for locus heterogeneity has been provided by the identification of other putative hereditary prostate cancer loci on Xq27-28, 1q42-43, and 1p36. The present study describes a combined analysis for six markers in the 1q24-25 region in 772 families affected by hereditary prostate cancer and ascertained by the members of the International Consortium for Prostate Cancer Genetics (ICPCG) from North America, Australia, Finland, Norway, Sweden, and the United Kingdom. Overall, there was some evidence for linkage, with a peak parametric multipoint LOD score assuming heterogeneity (HLOD) of 1.40 (P=.01) at D1S212. The estimated proportion of families (alpha) linked to the locus was.06 (1-LOD support interval.01-.12). This evidence was not observed by a nonparametric approach, presumably ...
http://www.fredhutch.org/en/labs/phs/projects/progress-study/pub.html
In silico polymorphism analysis for the development of simple sequence repeat and transposon markers and construction of...In silico polymorphism analysis for the development of simple sequence repeat and transposon markers and construction of...
In this study, we developed a high-density genetic linkage map, SKF2, of a total length of 2,166.4 cM consisting of 1,114 marker loci (Figure 1, Table 2, Additional file 6). Genetic linkage maps in Arachis spp. have been constructed using mapping populations derived from crosses between interspecific diploids [14, 19, 22, 23] or synthetic tetraploids [13, 27], as well as cultivated tetraploids [21, 24-26]. In addition, the integration of more than two maps by connecting common markers as anchors has been conducted to produce a higher number of marker loci than that on single maps [28-31]. While it is true that map integration is an effective way to increase marker loci on a single map, the development of new markers is still required to saturate linkage maps in peanut. As far as we know, the SKF2 map covering 2,166.4 cM with 1,114 loci is the highest-density genetic linkage map in Arachis, and probably covers a large portion of the peanut genome because the total length of the map is almost ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-12-80
Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat, Mammalian Genome | 10.1007/s003350010226 | DeepDyveGenome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat, Mammalian Genome | 10.1007/s003350010226 | DeepDyve
Read Genome-wide linkage analysis of inherited hydrocephalus in the H-Tx rat, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/genome-wide-linkage-analysis-of-inherited-hydrocephalus-in-the-h-tx-aW57NpwDhT
A genome-wide linkage scan for age at menarche in three populations of European descent<...
TY - JOUR. T1 - A genome-wide linkage scan for age at menarche in three populations of European descent. AU - Anderson, Carl A.. AU - Zhu, Gu. AU - Falchi, Mario. AU - van den Berg, Stephanie M.. AU - Treloar, Susan A.. AU - Spector, Timothy D.. AU - Martin, Nicholas G.. AU - Boomsma, Dorret I.. AU - Visscher, Peter M.. AU - Montgomery, Grant W.. PY - 2008/10. Y1 - 2008/10. N2 - Context: Age at menarche (AAM) is an important trait both biologically and socially, a clearly defined event in female pubertal development, and has been associated with many clinically significant phenotypes.Objective: The objective of the study was to identify genetic loci influencing variation in AAM in large population-based samples from three countries.Design/Participants: Recalled AAM data were collected from 13,697 individuals and 4,899 pseudo-independent sister-pairs from three different populations (Australia, The Netherlands, and the United Kingdom) by mailed questionnaire or interview. Genome-wide variance ...
https://www.research.ed.ac.uk/en/publications/a-genome-wide-linkage-scan-for-age-at-menarche-in-three-populatio
QTL analysis of flowering time and ripening traits suggests an impact of a genomic region on linkage group 1 in Vitis.
In the recent past, genetic analyses of grapevine focused mainly on the identification of resistance loci for major diseases such as powdery and downy mildew. Currently, breeding programs make intensive use of these results by applying molecular markers linked to the resistance traits. However, modern genetics also allows to address additional agronomic traits that have considerable impact on the selection of grapevine cultivars. In this study, we have used linkage mapping for the identification and characterization of flowering time and ripening traits in a mapping population from a cross of V3125 (Schiava Grossa × Riesling) and the interspecific rootstock cultivar Börner (Vitis riparia × Vitis cinerea). Comparison of the flowering time QTL mapping with data derived from a second independent segregating population identified several common QTLs. Especially a large region on linkage group 1 proved to be of special interest given the genetic divergence of the parents of the two ...
https://pub.uni-bielefeld.de/publication/2689802
A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF)...
Fingerprint Dive into the research topics of A genomewide linkage study of 1,933 families affected by premature coronary artery disease: The British Heart Foundation (BHF) Family Heart Study. Together they form a unique fingerprint. ...
https://pureportal.coventry.ac.uk/en/publications/a-genomewide-linkage-study-of-1933-families-affected-by-premature/fingerprints/?sortBy=alphabetically
Willoughby, Mol Vis 2005; 11:587-593. Table 2.Willoughby, Mol Vis 2005; 11:587-593. Table 2.
Table 2. LOD scores for linkage between cataract with microcornea and 22q11.2-q12.2 markers. Two-point LOD scores for linkage in microsatellite markers across the β-crystallin gene cluster in the chromosomal regions 22q11.2-q12.2. The maximum two-point lod score was achieved for D22S1114 at θ=0. Zmax, the maximum lod score achieved, is given for each marker. Significant linkage was found with microsatellite marker D22S1144 with pair-wise lod score exceeding 3.0.. ...
http://www.molvis.org/molvis/v11/a69/willoughby-table2.html
Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease | Journal of Medical...Genome-wide linkage and association mapping identify susceptibility alleles in ABCC4 for Kawasaki disease | Journal of Medical...
Methods and results A 26-family linkage study followed by fine mapping was performed in a cohort of 1284 KD subjects and their family members (total 3248 individuals). Suggestive evidence of disease linkage (logarithm of odds (LOD) ≥3.0, p,1.00×10−4) was found for five genomic locations (Chr 3q, 4q, 10p, 13q, 21q). Two of these loci (Chr 4q and Chr 13q) overlapped with validated findings from a recent KD genome-wide association study. Fine mapping analysis revealed three single nucleotide polymorphisms (SNPs) in ATP-binding cassette, subfamily C, member 4 (ABCC4) underlying the Chr 13q linkage peak showing evidence of association to KD (lowest p=8.82×10−5; combined OR 2.00, 95% CI 1.41 to 2.83). ABCC4 is a multifunctional cyclic nucleotide transporter that stimulates the migratory capacity of dendritic cells. It is also a mediator of prostaglandin efflux from human cells and is inhibited by non-steroidal anti-inflammatory medications such as aspirin. ...
http://jmg.bmj.com/content/early/2011/05/13/jmg.2010.086611
The Blood Pressure Program Review - Christian Goodman - Tried & TestedThe Blood Pressure Program Review - Christian Goodman - Tried & Tested
This is a comprehensive Christian Goodmans The blood pressure program Review. Does this program really work to help lower blood pressure?
https://linkingo.com/the-blood-pressure-program-review-christian-goodman/
Linkage of a gene causing high bone mass to human chromosome 11 (11q12- 13)<...
TY - JOUR. T1 - Linkage of a gene causing high bone mass to human chromosome 11 (11q12- 13). AU - Johnson, Mark L.. AU - Gong, Guodong. AU - Kimberling, William. AU - Recker, Susan M.. AU - Kimmel, Donald B.. AU - Recker, Robert R.. PY - 1997/6. Y1 - 1997/6. N2 - The purpose of this paper is to report the linkage of a genetic locus (designated HBM) in the human genome to a phenotype of very high spinal bone density, using a single extended pedigree. We measured spinal bone mineral density, spinal Z(BMD), and collected blood from 22 members of this kindred. DNA was genotyped on an Applied Biosystems model 377 (ABI PRISM Linkage Mapping Sets; Perkin Elmer Applied Biosystems), by use of fluorescence-based marker sets that included 345 markers. Both two-point and multipoint linkage analyses were performed, by use of affected/unaffected and quantitative-trait models. Spinal Z(BMD) for affected individuals (N = 12) of the kindred was 5.54 ± 1.40; and for unaffected individuals (N = 16) it was 0.41 ...
https://creighton.pure.elsevier.com/en/publications/linkage-of-a-gene-causing-high-bone-mass-to-human-chromosome-11-1
Linkage map of Salmonella typhimurium, edition VII<...
TY - JOUR. T1 - Linkage map of Salmonella typhimurium, edition VII. AU - Sanderson, K. E.. AU - Roth, J. R.. PY - 1988. Y1 - 1988. N2 - The genes of Salmonella typhimurium LT2 are located on a closed circular linkage map. The original map was determined by interrupted mating in F-mediated conjugation. More recent data are derived primarily from bacteriophage P22- and P1-mediated transduction and frome gene cloning and molecular analysis. The circular linkage map is set at 100 U to correspond with the 100-min map of Escherichia coli K-12. In this seventh edition of the linkage map, 750 genes are listed, with 680 of these located on the map and the remaining 70 being genes for which mutant alleles are known or which are cloned but not yet mapped. The linkage maps of S. typhimurium and E. coli K-12 are very similar. A plasmid, pSLT, present in all strains of LT2 except those from which it has been intentionally eliminated can carry mutations which affect the phenotype of the cell. Genetic materials ...
https://ucdavis.pure.elsevier.com/en/publications/linkage-map-of-salmonella-typhimurium-edition-vii
Linkage and Recombination - Basic Concepts, Calculating Linkage And Map Distance, Statistical Approaches - Chromosome, Genes,...
Linkage refers to the association and co-inheritance of two DNA segments because they reside close together on the same chromosome. Recombination is the process by which they become separated during crossing over, Physical linkage of genes simply means they are on the same chromosome. To be genetically linked, a pair of genes must be close enough that they are unlikely to be separated by crossing over. which occurs during meiosis. The existence of linkage and the frequency of recombination allow chromosomes to be mapped to determine the relative positions and distances of the genes and other DNA sequences on them. Linkage analysis is also a key tool for discovering the location and ultimate identity of genes for inherited diseases.. ...
http://medicine.jrank.org/pages/2479/Linkage-Recombination.html
Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19 |...Analysis of positional candidate genes in the AAA1 susceptibility locus for abdominal aortic aneurysms on chromosome 19 |...
Background Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA susceptibility locus...
https://rd.springer.com/article/10.1186/1471-2350-12-14
Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study | BMC Genomic Data | Full...Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study | BMC Genomic Data | Full...
Previously, we reported significant linkage of body mass index (BMI) to chromosomes 6 and 11 across six examinations, covering 28 years, of the Framingham Heart Study. These results were on all individuals available at each exam, thus the sample size varied from exam to exam. To remove any effect of sample size variation we have now constructed six subsets; for each exam individuals were only included if they were measured at every exam, i.e. for each exam, included individuals comprise the intersection of the original six exams. This strategy preferentially removed older individuals who died before reaching the sixth exam, thus the intersection datasets are smaller (n = 1114) and significantly younger than the full datasets. We performed variance components linkage analysis on these intersection datasets and on their sex-specific subsets. Results from the sex-specific genome scans revealed 11 regions in which a sex-specific maximum lodscore was at least 2.0 for at least one dataset. Randomization tests
https://bmcgenomdata.biomedcentral.com/articles/10.1186/1471-2156-7-7/figures/1
Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study | BMC Genomic Data | Full...Sex and age specific effects of chromosomal regions linked to body mass index in the Framingham Study | BMC Genomic Data | Full...
Previously, we reported significant linkage of body mass index (BMI) to chromosomes 6 and 11 across six examinations, covering 28 years, of the Framingham Heart Study. These results were on all individuals available at each exam, thus the sample size varied from exam to exam. To remove any effect of sample size variation we have now constructed six subsets; for each exam individuals were only included if they were measured at every exam, i.e. for each exam, included individuals comprise the intersection of the original six exams. This strategy preferentially removed older individuals who died before reaching the sixth exam, thus the intersection datasets are smaller (n = 1114) and significantly younger than the full datasets. We performed variance components linkage analysis on these intersection datasets and on their sex-specific subsets. Results from the sex-specific genome scans revealed 11 regions in which a sex-specific maximum lodscore was at least 2.0 for at least one dataset. Randomization tests
https://bmcgenomdata.biomedcentral.com/articles/10.1186/1471-2156-7-7/figures/4
Linkage study - ConservapediaLinkage study - Conservapedia
A linkage study aims at establishing linkage between genes. Linkage is the tendency for genes and other genetic markers to be inherited together because of their location near one another on the same chromosome. A genetic marker is simply a segment of DNA with an identifiable physical location on a chromosome whose inheritance can be followed. A genetic marker can have a function and thus be a gene. Or a marker can be a section of DNA with no known function. Because DNA segments that lie near each other on a chromosome tend to be inherited together, markers are often used as tools for tracking the inheritance pattern of a gene that has not yet been identified but whose approximate location is known. The statistical estimate of whether two loci are likely to lie near each other on a chromosome and are therefore likely to be inherited together is called a LOD score. A LOD score of 3 or more is generally taken to indicate that the two loci are linked and are close to one another. Today linkage ...
http://www.conservapedia.com/Linkage_study
Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15...Significant evidence of one or more susceptibility loci for endometriosis with near-Mendelian inheritance on chromosome 7p13-15...
The collaborative International Endogene Study consists of two data sets (Oxford and Australia) comprising 1176 families with multiple affecteds.. The aim of the research team was to investigate whether the apparent concentration of cases in a proportion of families could be explained by one or more rare variants with (near-)Mendelian autosomal inheritance.. Linkage analyses (aimed at finding chromosomal regions harbouring disease-predisposing genes) were conducted in families with three or more affected women with endometriosis. (Oxford: n=52; Australia: n=196). In the Oxford data set, a non-parametric linkage score (Kong & Cox (K&C) Log of ODds (LOD)) of 3.52 was observed on chromosome 7p (genome-wide significance P=0.011). A parametric MOD score (equal to maximum LOD maximized over 357 possible inheritance models) of 3.89 was found at 65.72 cM (D7S510) for a dominant model with reduced penetrance.. After including the Australian data set, the non-parametric K&C LOD of the combined data set ...
http://endometriosis.org/news/research/evidence-of-susceptibility-loci-for-endometriosis-with-near-mendelian-inheritance-on-chromosome-7p13-15/
A genome-wide linkage scan and targeted family-based association analysis of dyslexia - UBC Library Open CollectionsA genome-wide linkage scan and targeted family-based association analysis of dyslexia - UBC Library Open Collections
Learning, knowledge, research, insight: welcome to the world of UBC Library, the second-largest academic research library in Canada.
https://open.library.ubc.ca/cIRcle/collections/ubctheses/24/items/1.0066433
Localization of a gene for familial recurrent arthritis<...
TY - JOUR. T1 - Localization of a gene for familial recurrent arthritis. AU - Wise, Carol A.. AU - Bennett, Lynda B.. AU - Pascual, Virginia. AU - Gillum, Joseph D.. AU - Bowcock, Anne M.. PY - 2000/12/10. Y1 - 2000/12/10. N2 - Objective. To localize the gene for familial recurrent arthritis via a genome-wide linkage scan in an extended kindred with the disease. Methods. A 3-generation family in which 9 members were diagnosed with juvenile idiopathic arthritis (JIA) was ascertained. In this family the disease was of very early onset and included episodic inflammation leading to eventual destruction of joints, muscle, and skin. We treated this disorder as a distinct clinical entity that we have named familial recurrent arthritis. A genome-wide linkage scan with polymorphic microsatellites at 10 - 15-cM resolution was initiated. Results. The genome-wide scan generated a maximum 2-point logarithm of odds score with D15S211 (Z(max) = 3.27 at θ(max) = 0.0010). Haplotype reconstruction defined a ...
https://utsouthwestern.pure.elsevier.com/en/publications/localization-of-a-gene-for-familial-recurrent-arthritis
The rate we acquire genetic mutations could help predict lifespan, fertility - ScienceDaily - The Hub Press
However, Cawthon and colleagues theorized that these mutations could be a biomarker for rates of aging and potentially predict lifespan in younger individuals as well as fertility in women.. The researchers sequenced DNA from 61 men and 61 women who were grandparents in 41 three-generational families. The families were part of the Centre dEtude du Polymorphisme Humain (CEPH) consortium, which was central to many key investigations that have contributed toward a modern understanding of human genetics.. The researchers analyzed blood DNA sequences in trios consisting of pairs of grandparents from the first generation and one of their children from the second generation. Thats because germline mutations are passed on to their offspring. Mutations found in the childs blood DNA that were not present in either parents blood DNA were then inferred to have originated in the parents germlines. The researchers were then able to determine which parent each germline mutation came from, and, therefore, ...
https://thehub.press/2020/06/21/the-rate-we-acquire-genetic-mutations-could-help-predict-lifespan-fertility-sciencedaily/
linkage analysis method
Patients with osteosarcoma were diagnosed at the Hemato-Oncology Unit, Hospital Infantil La Paz, Madrid. Linkage Analysis and genotyping analysis techniques with bioinformatics tools. Hashimoto T, Takahashi R, Yandell DW, et al. O ( Cawkwell L, Bell SM, Lewis FA, et al. Application of linkage analysis to genetic counselling in families with hereditary, 14. If you continue browsing the site, you agree to the use of cookies on this website. 800-638-3030 (within USA), 301-223-2300 (international). O In sporadic (hereditary nonfamilial) retinoblastoma, genotyping is irrelevant but the microsatellite analysis is important to the detection of large deletions, and functions as prescreening in the search of mutations that help to determine the risk in offspring. Lippincott Journals Subscribers, use your username or email along with your password to log in. Application of intragenic DNA probes in prenatal screening for, 29. Molecular detection of constitutional deletions in patients with, 2. Although ...
https://carolienmertens.com/blog/b38329-linkage-analysis-method
Genetic linkage studies in schizophrenia | BJPsych BulletinGenetic linkage studies in schizophrenia | BJPsych Bulletin
Thank you for your interest in spreading the word about BJPsych Bulletin.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
http://pb.rcpsych.org/content/21/4/255
High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q, Mammalian Genome | 10.1007...High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q, Mammalian Genome | 10.1007...
Read High-resolution mapping of a linkage group on mouse chromosome 8 conserved on human chromosome 16Q, Mammalian Genome on DeepDyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips.
https://www.deepdyve.com/lp/springer_journal/high-resolution-mapping-of-a-linkage-group-on-mouse-chromosome-8-CfdKQB50JF
QIMR Genetic Epidemiology Laboratory Home Page
Genes involved in pathways regulating body weight may operate differently in men and women. To determine whether sex-limited genes influence the obesity-related phenotype body mass index (BMI), we have conducted a general nonscalar sex-limited genome-wide linkage scan using variance components analysis in Mx (Neale, 2002). BMI measurements and genotypic data were available for 2053 Australian female and male adult twins and their siblings from 933 families. Clinical measures of BMI were available for 64.4% of these individuals, while only self-reported measures were available for the remaining participants. The mean age of participants was 39.0 years of age (SD 12.1 years). The use of a sex-limited linkage model identified areas on the genome where quantitative trait loci (QTL) effects differ between the sexes, particularly on chromosome 8 and 20, providing us with evidence that some of the genes responsible for BMI may have different effects in men and women. Our highest linkage peak was ...
https://genepi.qimr.edu.au/general/publicationsfulllisting.cgi?pmid=16363087
CCTG 593: Testing and Linkage to Care - Full Text View - ClinicalTrials.govCCTG 593: Testing and Linkage to Care - Full Text View - ClinicalTrials.gov
Duration: Each subject who agrees to linkage will receive ALERT follow-up until successful linkage or 60 days following enrollment for linkage to care or 90 days following enrollment for linkage to PrEP, whichever comes first. The duration of the 593 project will be for 3.5 years or until all subjects have been enrolled and successfully linked, or 60 days pass for linkage to care or 90 days for linkage to PrEP.. Sample Size: Up to 600 subjects will be tested and offered linkage across all CCTG sites: LA County-USC Medical Center, Harbor-UCLA/City of Long Beach Department of Health and Human Services, UCSD/San Diego Health and Human Services Agency.. Study Population: Eligible subjects will include any persons 18 years of age or older who have been tested for HIV at one of the CCTG testing sites (LA County + USC, Long Beach Department of Health and Human Services, and San Diego Health and Human Services Agency). ...
https://clinicaltrials.gov/show/NCT01941121?order=404
Difference between revisions of BISC 219/F10: Gene Linkage - OpenWetWareDifference between revisions of BISC 219/F10: Gene Linkage - OpenWetWare
To start a mating, place 4 to 5 young adult (or L4) males on a plate with 4 young adult (or L4) hermaphrodites. We will use plates seeded with a very small drop of OP50 bacteria for our crosses. Using only a small central area of the plate helps our worms find each other quickly and mate. The self-cross progeny produced by the hermaphrodite must be distinguished from outcross progeny. Generally, the hermaphrodite is homozygous for a visible marker and the progeny from self-crossing will show the same phenotype as the hermaphrodite, while progeny from a cross with a wild type male (outcross) will be heterozygous for the maternal marker and thus appear wild type if the mutation is recessive. When no other way is available to distinguish selfcross from outcross progeny, only males are scored. It is the outcross progeny of a mating that are of interest; essentially, all male progeny are crossprogeny. For this reason it is critical than the male transfer not be contaminated with any eggs or ...
https://openwetware.org/wiki/?title=BISC_219/F10:_Gene_Linkage&diff=450393&oldid=450391
Human Genome News January-February 1995Human Genome News January-February 1995
A course for researchers who have a basic understanding of linkage analysis but little or no experience in using linkage programs will be held June 12-16 at Columbia Presbyterian Medical Center in New York City. Topics will include an introduction to linkage analysis, practical aspects of data collection, strategies and methods of linkage analysis, incomplete penetrance (narrow and wide definition), inbreeding loops, simple risk calculations, and introduction to computer simulation. A major part of the course will consist of exercises using LINKAGE software programs. Attendance is limited to 30. [Contact: Katherine Montague (212/960-2507, Fax: /568-2750, [email protected]).]. ...
http://web.ornl.gov/sci/techresources/Human_Genome/publicat/hgn/v6n5/13linkage.shtml
A genetic linkage map of the mouse: current applications and future prospects | ScienceA genetic linkage map of the mouse: current applications and future prospects | Science
Thank you for your interest in spreading the word about Science.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
https://science.sciencemag.org/content/262/5130/57?ijkey=dbd4a9ecd057b1cc54a37d05dc934a312fd963ac&keytype2=tf_ipsecsha
ADHDgene Database
Linkage of genomewide scan: LOD=1.98, MLS=2.829, NPL=3 with ...... Linkage of genomewide scan: LOD=1.98, MLS=2.829, NPL=3 with marker D17S799; Family-specific linkage of fine mapping: LOD=3.4, NPLall Zb >12.0 with marker D17S1876;LOD=3.5, NPLall Zb >12.0 with marker D17S678;LOD=3.9, NPLall Zb >12.0 with marker D17S1881;LOD=3.8, NPLall Zb >12.0 with marker D17S1844;LOD=3.7, NPLall Zb >12.0 with marker D17S1791; Linkage of fine mapping in combined families: LOD=2.5, NPLall Zb >12.0 with marker D17S1876 More... ...
http://adhd.psych.ac.cn/regionDetail.do?name=17p11
Identification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data | BMC Genetics | Full TextIdentification of polymorphisms explaining a linkage signal: application to the GAW14 simulated data | BMC Genetics | Full Text
In contrast, Dupuis and Van Eerdewegh HST method [3] conditions on parental genotypes. They argue that if a parent is homozygous at all risk SNPs in a linked region, then it should not matter which haplotype is transmitted to affected offspring because they confer the same disease susceptibility. Hence, there should be no excess IBD sharing by affected siblings inherited from parents who are homozygous at all risk variants. However, if a particular set of SNPs is in linkage equilibrium with the susceptibility SNPs, the sharing probabilities should not depend on the parental genotypes, and the probabilities of IBD sharing from homozygous and heterozygous parents should be the same. For the intermediate situation in which the tested SNPs are in LD with risk variants, some increased sharing may be observed from homozygous parents, and the degree of excess sharing will depend on the LD between the tested SNPs and the disease SNPs. Therefore, they propose to compare the observed IBD sharing from ...
https://bmcgenet.biomedcentral.com/articles/10.1186/1471-2156-6-S1-S88
Papers with the keyword STMI | Read by QxMDPapers with the keyword STMI | Read by QxMD
Linkage of at least two complementation groups of ataxia-telangiectasia (AT) to the chromosomal region 11q23 is now well established. We provide here an 18-point map of the surrounding genomic region, derived from linkage analysis of 40 CEPH families. On the basis of this map, 111 AT families from Turkey, Israel, England, Italy, and the United States were analyzed, localizing the AT gene(s) to an 8-cM sex-averaged interval between the markers STMY and D11S132/NCAM. A new Monte Carlo method for computing approximate location scores estimates this location as being at least 10(8) times more likely than the next most likely interval, with a support interval midway between STMY and D11S132 that is either 5 ...
https://www.readbyqxmd.com/keyword/1605
Genetic linkageGenetic linkage
Recombination frequency is a measure of genetic linkage and is used in the creation of a genetic linkage map. Recombination ... A linkage map is not a physical map (such as a radiation reduced hybrid map) or gene map. Linkage analysis is a genetic method ... Linkage maps help researchers to locate other markers, such as other genes by testing for genetic linkage of the already known ... A linkage map (also known as a genetic map) is a table for a species or experimental population that shows the position of its ...
https://en.wikipedia.org/wiki/Genetic_linkage
Genetic heterogeneityGenetic heterogeneity
Initial research on genetic heterogeneity was conducted using genetic linkage analyses, which map genetic loci of related ... 8 (1): 6. doi:10.1016/S1672-2930(13)50002-X. Teare, Dawn; Barrett, Jennifer (September 15, 2005). "Genetic linkage studies". ... Genetic heterogeneity occurs through the production of single or similar phenotypes through different genetic mechanisms. There ... Disorders on the Autism spectrum have high levels of genetic heterogeneity and result from multiple genetic pathways including ...
https://en.wikipedia.org/wiki/Genetic_heterogeneity
Family studyFamily study
Linkage studies aimed at identifying specific genetic loci that have a moderate to large effect on risk Genetic linkage occurs ... "linkage , Learn Science at Scitable". www.nature.com. Retrieved 2021-11-05. "3.10: Genetic Linkage". Biology LibreTexts. 2016- ... In genetic epidemiology, family studies are studies of whether a disease or trait "runs in a family". In other words, they are ... Chromosomes carry genetic information across all of it, each gene having its specific location and position. There are 40,000 ...
https://en.wikipedia.org/wiki/Family_study
Gene mapGene map
They found that the CF gene resides around 7q31-q32 (see chromosomal nomenclature). Gene mapping Genetic linkage Nussbaum, ... Pulst, Stefan M. (June 1999). "Genetic Linkage Analysis". JAMA Neurology. 56 (6): 667-672. doi:10.1001/archneur.56.6.667. PMID ... Genetic mapping on the other hand uses genetic techniques to indirectly find association between genes. Techniques can include ... These sites usually contain genetic polymorphisms making them sources of viable genetic markers (as they differ from other ...
https://en.wikipedia.org/wiki/Gene_map
Three-point crossThree-point cross
"Genetic linkage & mapping". Khan Academy. AMGEN Foundation. Retrieved 2021-03-29. (Genetics). ...
https://en.wikipedia.org/wiki/Three-point_cross
CunicultureCuniculture
The early genetic research focused on linkage distance between various gross phenotypes using linkage analysis. Between 1924 ... Castle, W. E.; Sawin, P. B. (1941). "Genetic linkage in the rabbit". Proceedings of the National Academy of Sciences. 27 (11): ... Each of these groups has different needs for genetic information. In the biomedical research community and the pharmaceutical ... Carneiro, M. (2011). "The Genetic Structure of Domestic Rabbits". Molecular Biology and Evolution. 28 (6): 1801-1816. doi: ...
https://en.wikipedia.org/wiki/Cuniculture
Natural computingNatural computing
ISBN 978-3-540-23774-7. Thierens, Dirk (11 September 2010). "The Linkage Tree Genetic Algorithm". Parallel Problem Solving from ... Genetic algorithms have been used to optimize computer programs, called genetic programming, and today they are also applied to ... Genetic algorithms initially consisted of an input population of individuals encoded as fixed-length bit strings, the genetic ... "On the performance of linkage-tree genetic algorithms for the multidimensional knapsack problem". Neurocomputing. 146: 17-29. ...
https://en.wikipedia.org/wiki/Natural_computing
Jürg OttJürg Ott
Ott, Jurg (1999). Analysis of human genetic linkage. Baltimore: Johns Hopkins University Press. ISBN 978-0-8018-6140-6. OCLC ...
https://en.wikipedia.org/wiki/Jürg_Ott
Rex mutationRex mutation
Castle, WE; Sawin, PB (1941). "Genetic linkage in the rabbit". Proceedings of the National Academy of Sciences. 27 (11): 519- ... Of the 3 genetic sources of rex rabbits, the one due to the gene r1 is the most popular with fanciers and has the simple ... It was not linked with any other genes known at the time although it was eventually found to be in the same linkage group as r2 ... The diversity of genetic factors results in variable coat thickness/density and fur length. A great variety exists within rex ...
https://en.wikipedia.org/wiki/Rex_mutation
Genetic associationGenetic association
Disease gene identification Association mapping Family based QTL mapping Genetic epidemiology Genetic linkage Genome-wide ... this is known as genetic linkage.[citation needed] Linkage disequilibrium (LD) is a term used in the study of population ... NATURE GENETICS v. 40 N.7 July 2008 pp 841-843 A list of computer programs for genetic analysis including genetic association ... Genetic association studies are performed to determine whether a genetic variant is associated with a disease or trait: if ...
https://en.wikipedia.org/wiki/Genetic_association
Epidemiology of autismEpidemiology of autism
Genetic linkage analysis has been inconclusive; many association analyses have had inadequate power. Studies have examined more ... As late as the mid-1970s there was little evidence of a genetic role in autism; evidence from genetic epidemiology studies now ... It has been shown to be related to genetic disorders and with epilepsy. ASD is believed to be largely inherited, although the ... Trottier G, Srivastava L, Walker CD (March 1999). "Etiology of infantile autism: a review of recent advances in genetic and ...
https://en.wikipedia.org/wiki/Epidemiology_of_autism
GeneGene
Lobo I, Shaw K (2008). "Discovery and Types of Genetic Linkage". Nature Education Knowledge. SciTable. Nature Publishing Group ... The genetic variation in relative frequencies of different alleles in a population is due to both natural selection and genetic ... The related term synthetic biology is sometimes used to refer to extensive genetic engineering of an organism. Genetic ... known as genetic linkage). Genes that are very close are essentially never separated because it is extremely unlikely that a ...
https://en.wikipedia.org/wiki/Gene
Haseman-Elston regressionHaseman-Elston regression
Penrose, L.S. (1938). "Genetic linkage in graded human characters". Annals of Eugenics. 8 (3): 233-7. doi:10.1111/j.1469- ... Genetic linkage analysis, All stub articles, Genetics stubs). ... A much earlier source of sib-pair linkage implementation was, ... Penrose, L.S. (1935). "The detection of autosomal linkage in data which consist of pairs of brothers and sisters of unspecified ... Haseman, J. K.; Elston, R. C. (March 1972). "The investigation of linkage between a quantitative trait and a marker locus". ...
https://en.wikipedia.org/wiki/Haseman–Elston_regression
Heritability of autismHeritability of autism
The Autism Genome Project database contains genetic linkage and CNV data that connect autism to genetic loci and suggest that ... Genetic linkage analysis has been inconclusive; many association analyses have had inadequate power. For each autistic ... March 2007). "Mapping autism risk loci using genetic linkage and chromosomal rearrangements". Nature Genetics. 39 (3): 319-28. ... "Exploratory subsetting of autism families based on savant skills improves evidence of genetic linkage to 15q11-q13". Journal of ...
https://en.wikipedia.org/wiki/Heritability_of_autism
David SiegmundDavid Siegmund
Siegmund, David (1998). "Genetic linkage analysis: An irregular statistical problem". Doc. Math. (Bielefeld) Extra Vol. ICM ...
https://en.wikipedia.org/wiki/David_Siegmund
Multiplex polymerase chain reactionMultiplex polymerase chain reaction
"Welcome , Forensic DNA Profiling Facility" (PDF). Reis, Andre (1991). "PCR in Linkage Analysis of Genetic Diseases". PCR Topics ... Pathogen Identification High Throughput SNP Genotyping Mutation Analysis Gene Deletion Analysis Template Quantitation Linkage ...
https://en.wikipedia.org/wiki/Multiplex_polymerase_chain_reaction
NeurogeneticsNeurogenetics
This process is referred to sometimes as linkage analysis. By the 1990s ever advancing technology had made genetic analysis ... Tanzi RE (October 1991). "Genetic linkage studies of human neurodegenerative disorders". Current Opinion in Neurobiology. 1 (3 ... focusing in particular how the genetic code an organism carries affects its expressed traits. Mutations in this genetic ... The discovery of linkages could then lead to therapeutic drugs, which could reverse brain degeneration. One of the most ...
https://en.wikipedia.org/wiki/Neurogenetics
Gametic phaseGametic phase
... is influenced by genetic linkage. Taylor, Duncan; Bright, Jo-Anne; Buckleton, John S. (2016). "Biological basis ...
https://en.wikipedia.org/wiki/Gametic_phase
Eliminative materialismEliminative materialism
This is the phenomenon of genetic linkage. The traits that the genes coded for will be coextensive in a population because the ... is wait around for the genetic material to be broken at just the right place between their respective genes. Once this happens ... process Darwin discovered can't tell the difference between these two genes or their traits until cross-over breaks the linkage ...
https://en.wikipedia.org/wiki/Eliminative_materialism
VPS13AVPS13A
... genetic linkage to chromosome 9q21". American Journal of Human Genetics. 61 (4): 899-908. doi:10.1086/514876. PMC 1715977. PMID ... clinical and genetic findings in three families from the Arabian peninsula". Movement Disorders. 18 (4): 403-7. doi:10.1002/mds ...
https://en.wikipedia.org/wiki/VPS13A
PTPN14PTPN14
"The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246-339. doi:10.1038/ng0694supp-246. PMID ...
https://en.wikipedia.org/wiki/PTPN14
Family-based QTL mappingFamily-based QTL mapping
Genetic linkage is the phenomenon where by alleles at different loci cosegregate in families. The strength of cosegregation is ... CRC Press, Boca Raton, pp 145-161 Lander, E. S.; Green, P. (1987). "Construction of multilocus genetic linkage maps in humans ... Extended pedigree are attractive for linkage-based analysis. Linkage and association analysis are primary tools for gene ... In linkage studies, we seek to identify the loci that cosegregate with a specific genomic region, tagged by polymorphic markers ...
https://en.wikipedia.org/wiki/Family-based_QTL_mapping
SLURP1SLURP1
Fischer J, Bouadjar B, Heilig R, Fizames C, Prud'homme JF, Weissenbach J (1999). "Genetic linkage of Meleda disease to ...
https://en.wikipedia.org/wiki/SLURP1
FLT4FLT4
... evidence for linkage and genetic heterogeneity". Human Molecular Genetics. 7 (13): 2073-8. doi:10.1093/hmg/7.13.2073. PMID ...
https://en.wikipedia.org/wiki/FLT4
Helen Donis-KellerHelen Donis-Keller
She continued to work on the genetic linkage map and led research into understanding the genetic basis of cystic fibrosis, ... Doniskeller, H (October 1987). "A genetic linkage map of the human genome". Cell. 51 (2): 319-337. doi:10.1016/0092-8674(87) ... National Academies Press (US). Group, NIH/CEPH Collaborative Mapping (1992). "A Comprehensive Genetic Linkage Map of the Human ... "A Genetic Linkage Map of the Human Genome" (PDF). Cell. 51 (2): 319-337. doi:10.1016/0092-8674(87)90158-9. PMID 3664638. S2CID ...
https://en.wikipedia.org/wiki/Helen_Donis-Keller
Scheuermanns diseaseScheuermann's disease
McKenzie L, Sillence D (January 1992). "Familial Scheuermann disease: a genetic and linkage study". Journal of Medical Genetics ...
https://en.wikipedia.org/wiki/Scheuermann's_disease
XRCC1XRCC1
"The 1993-94 Généthon human genetic linkage map". Nature Genetics. 7 (2 Spec No): 246-339. doi:10.1038/ng0694supp-246. PMID ... Hung RJ, Hall J, Brennan P, Boffetta P (Nov 2005). "Genetic polymorphisms in the base excision repair pathway and cancer risk: ...
https://en.wikipedia.org/wiki/XRCC1
Phycomyces blakesleeanusPhycomyces blakesleeanus
A genetic linkage map was developed for P.blakesleeanus. This genetic map was constructed from 121 progeny of a cross between ... Chaudhary S, Polaino S, Shakya VP, Idnurm A (2013). "A new genetic linkage map of the zygomycete fungus Phycomyces ...
https://en.wikipedia.org/wiki/Phycomyces_blakesleeanus
Dennis DraynaDennis Drayna
Drayna, D.; White, R. (1985-11-15). "The genetic linkage map of the human X chromosome". Science. 230 (4727): 753-758. Bibcode: ... where he created the first full length genetic linkage map of the human X chromosome. After completing his post-doctoral ... "Mice with genetic defect for human stuttering offer new insight into speech disorder , Washington University School of Medicine ... In 2010, Drayna uncovered the first genetic basis of stuttering in humans. Since the initial discovery, he has expanded the ...
https://en.wikipedia.org/wiki/Dennis_Drayna
F13BF13B
1987). "Coagulation factor XIII: genetic linkage studies with F13B". Genet. Epidemiol. 4 (1): 43-9. doi:10.1002/gepi.1370040106 ... 1993). "Two genetic defects in a patient with complete deficiency of the b-subunit for coagulation factor XIII". Blood. 82 (1 ...
https://en.wikipedia.org/wiki/F13B
MetabolismMetabolism
These genetic modifications usually aim to reduce the amount of energy used to produce the product, increase yields and reduce ... a glycerol molecule attached to three fatty acids by ester linkages is called a triacylglyceride. Several variations on this ... Nucleic acids are critical for the storage and use of genetic information, and its interpretation through the processes of ... Class of genetic diseases Iron-sulfur world hypothesis - Hypothetical scenario for the origin of life, a "metabolism first" ...
https://en.wikipedia.org/wiki/Metabolism
HLA-A36HLA-A36
HLA DR3-DQ2 linkage and frequency indicates a strong possibility of a recent migration from either North or West Africa in ... Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in ... 2001). "HLA class I in three West African ethnic groups: genetic distances from sub-Saharan and Caucasoid populations". Tissue ...
https://en.wikipedia.org/wiki/HLA-A36
InterferonInterferon
However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and ... Tan YH, Tischfield J, Ruddle FH (February 1973). "The linkage of genes for the human interferon-induced antiviral protein and ... "Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance". Nature. 461 (7262): 399-401. Bibcode: ...
https://en.wikipedia.org/wiki/Interferon
PDCD10PDCD10
Guclu B, Ozturk AK, Pricola KL, Seker A, Ozek M, Gunel M (Nov 2005). "Cerebral venous malformations have distinct genetic ... "Multilocus linkage identifies two new loci for a mendelian form of stroke, cerebral cavernous malformation, at 7p15-13 and ... a clinical and genetic study". Archives of Ophthalmology. 124 (6): 885-6. doi:10.1001/archopht.124.6.885. PMID 16769843. Chen ...
https://en.wikipedia.org/wiki/PDCD10
Congenital mirror movement disorderCongenital mirror movement disorder
That is, the severity of clinical signs and symptoms does not correlate with the type of genetic variant. Mutations in the ... have been found in many CMM disorder patients through genome-wide linkage analysis and exome sequencing. In a mouse model, ... Experiments in mice also support the claim that CMM disorder is associated with genetic mutations in DCC. Kanga mice, lacking ... Congenital mirror movement disorder (CMM disorder) is a rare genetic neurological disorder which is characterized by mirrored ...
https://en.wikipedia.org/wiki/Congenital_mirror_movement_disorder
UteroglobinUteroglobin
However contrary to the animal model claims, human genetic data might suggest that the effect may be indirect Uteroglobin ... "Human CC10 gene expression in airway epithelium and subchromosomal locus suggest linkage to airway disease". Am. J. Physiol. ...
https://en.wikipedia.org/wiki/Uteroglobin
GenealogyGenealogy
"The Genetic Genealogy Standards". The Genetic Genealogy Standards. Archived from the original on 24 July 2019. Retrieved 23 ... G. J. A. Guth, "Surname Spellings and Computerised Record Linkage," Historical Methods Newsletter, vol. 10, no. 1, pp. 10-19, ... "The History of Genetic Genealogy and Unknown Parentage Research: An Insider's View." Journal of Genetic Genealogy 8.1 (2016): ... Individual genetic test results are collected in databases to match people descended from a relatively recent common ancestor. ...
https://en.wikipedia.org/wiki/Genealogy
Design structure matrixDesign structure matrix
A DSM is a square matrix, representing linkages between the system elements. The system elements are often labeled in the rows ... Sequencing algorithms (using optimization, genetic algorithms) are typically trying to minimize the number of feedback loops ... In modeling activities precedence it allows representing feedback linkages that cannot be modeled by Gantt chart/PERT modeling ... The marking then has developed to indicate quantitative relation Numeric DSM indicating the "strength" of the linkage, or ...
https://en.wikipedia.org/wiki/Design_structure_matrix
Lactuca serriolaLactuca serriola
This genetic diversity is considered a resource for lettuce breeding because it provides a greater variety of genes to be used ... These genes are mapped in four linkage groups, so the genes within each group will be more likely to be inherited together. ... Farrara, B. F.; Ilot, T. W.; Michelmore, R. W. (1987). "Genetic analysis of factors for resistance to downy mildew Bremia ... Samples of L. serriola can be found around the world with genetic diversity between populations regarding the Dm genes. ...
https://en.wikipedia.org/wiki/Lactuca_serriola
Lyme diseaseLyme disease
The Lyme-related Borrelia species are collectively known as Borrelia burgdorferi sensu lato, and show a great deal of genetic ... Eisen L, Eisen RJ (September 2016). "Critical evaluation of the linkage between tick-based risk measures and the occurrence of ... Polymerase chain reaction (PCR) tests for Lyme disease have also been developed to detect the genetic material (DNA) of the ... this is more common after infection by certain Borrelia strains in people with certain genetic and immunologic characteristics ...
https://en.wikipedia.org/wiki/Lyme_disease
Postpartum psychosisPostpartum psychosis
In a disorder with a strong genetic element and links to the reproductive process, costly imaging, molecular-genetic and ... Among the outstanding contributions were Delay's unique investigation using serial curettage and Kendell's record-linkage study ... The genetic, anatomical and neurochemical basis of bipolar disorder is at present unknown, and is one of the most important ... genome-wide significant evidence for linkage to chromosome 16. American Journal of Psychiatry 164: 1099-1104. Lewis K J S, ...
https://en.wikipedia.org/wiki/Postpartum_psychosis
HLA A1-B8-DR3-DQ2HLA A1-B8-DR3-DQ2
... genetic) linkage between A1 and B1, this was extended to Cw7 locus. And while the level of A-B linkage in general was nowhere ... Linkage could not be extended to HLA-DPB1 locus. Outside of Europe the DRB1*0301 and DR3-DQ2 loci have been linked to disease ... Linkage with disease could more firmly be attributed to B8::DQ2 portion of A1::DQ2 relative to A30-B18::DQ2, indicating some ... June 2004). "Genetic polymorphisms in tumor necrosis factor (TNF)-alpha and TNF-beta in a population-based study of systemic ...
https://en.wikipedia.org/wiki/HLA_A1-B8-DR3-DQ2
Classical geneticsClassical genetics
Linkage maps are still used today, especially in breeding for plant improvement. After the discovery of the genetic code and ... A key discovery of classical genetics in eukaryotes was genetic linkage. The observation that some genes do not segregate ... The genotype of an offspring is known as its genetic makeup. The alleles of genes can either be dominant or recessive. A ... Some classical genetic ideas have been supplanted with the mechanistic understanding brought by molecular discoveries, but many ...
https://en.wikipedia.org/wiki/Classical_genetics
Trichorrhexis invaginataTrichorrhexis invaginata
A Guide to Clinical Diagnosis, Genetic Counseling, and Therapy. Berlin: Springer Verlag, 1989. Ali M, Marks R, Young E, et al. ... by linkage analysis and homozygosity mapping". The American Journal of Human Genetics. 66 (3): 914-21. doi:10.1086/302824. ISSN ...
https://en.wikipedia.org/wiki/Trichorrhexis_invaginata
Conservation biologyConservation biology
Applied ecology Bird observatory Conservation-reliant species Ecological extinction Gene pool Genetic erosion Genetic pollution ... Some animals, such as amphibians with their semi-permeable skin and linkages to wetlands, have an acute sensitivity to ... The meeting was prompted due to concern over tropical deforestation, disappearing species, and eroding genetic diversity within ... including genetic, population and ecosystem diversity. Extensive, systematic, and rapid rates of biodiversity loss threatens ...
https://en.wikipedia.org/wiki/Conservation_biology
Arabis alpinaArabis alpina
The first genetic linkage map has been created and the first phenotypes, especially perenniality, are tackled by QTL mapping. A ... In genetic terms, the highest diversity is found in Asia Minor. In central and northern Europe, A. alpina seems to be ...
https://en.wikipedia.org/wiki/Arabis_alpina
Secret Warriors (2017 series)Secret Warriors (2017 series)
And Sinister loves a genetic crisis as much as the next insane geneticist. [...] I knew early on that we wanted the book to be ... 2". He highlighted that the only linkage between the volumes is Daisy Johnson - "it's certainly less espionage-focused and more ...
https://en.wikipedia.org/wiki/Secret_Warriors_(2017_series)
RNF144ARNF144A
The ubiquitin ligase activity of RNF144A catalyzes ubiquitin linkages at the K6-, K11- and K48- positions of ubiquitin in vitro ... Somatic mutations of RNF144A have been catalogued in cancer genetic databases in several primary human tumors, including breast ... Michel MA, Swatek KN, Hospenthal MK, Komander D (October 2017). "Ubiquitin Linkage-Specific Affimers Reveal Insights into K6- ...
https://en.wikipedia.org/wiki/RNF144A
Waldenström macroglobulinemiaWaldenström macroglobulinemia
There are genetic factors, with first-degree relatives of Waldenström macroglobulinemia patients shown to have a highly ... "Genomewide linkage screen for Waldenstrom macroglobulinemia susceptibility loci in high-risk families". American Journal of ... "Waldenstrom macroglobulinemia". Genetic and Rare Diseases Information Center (GARD) - an NCATS Program. Retrieved 2018-04-17. ... Although believed to be a sporadic disease, studies have shown increased susceptibility within families, indicating a genetic ...
https://en.wikipedia.org/wiki/Waldenström_macroglobulinemia
Fusarium oxysporum f.sp. cubenseFusarium oxysporum f.sp. cubense
Researchers at University Sains Malaysia are examining variability in the genome of the pathogen and its genetic variability is ... One study of the linkage disequilibrium of gametes showed relatively high disequilibrium and another a high degree of ... correlation between independent genetic markers, both of which are diagnostic for a lack of recombination and thus a clonal ...
https://en.wikipedia.org/wiki/Fusarium_oxysporum_f.sp._cubense
Snagger (software)Snagger (software)
de Bakker P. I., Yelensky R., Pe'er I., Gabriel S. B., Daly M. J., Altshuler D. (2005). "Efficiency and power in genetic ... Snagger is a bioinformatics software program for selecting tag SNPs using pairwise r2 linkage disequilibrium. It is implemented ...
https://en.wikipedia.org/wiki/Snagger_(software)
Prostate cancerProstate cancer
At a genetic level, prostate cancer visibility on MRI seems to be linked with genetic features of aggressive disease including ... February 2002). "Germline mutations in the ribonuclease L gene in families showing linkage with HPC1". Nature Genetics. 30 (2 ... Inherited genetic variation of the chromosome 8q24 locus, one that is prominently observed through genome-wide association ... Dupont WD, Breyer JP, Johnson SH, Plummer WD, Smith JR (May 2021). "Prostate cancer risk variants of the HOXB genetic locus". ...
https://en.wikipedia.org/wiki/Prostate_cancer
Mapuche historyMapuche history
A cultural linkage of this sort may help explain parallels in mythological cosmologies among Mapuches and peoples of the ... Ritchie Key, Mary (1978). "Araucanian genetic relationships". International Journal of American Linguistics. 44 (4): 280-293. ... "HLA genetic profile of Mapuche (Araucanian) Amerindians from Chile". Molecular Biology Reports. 40 (7): 4257-4267. doi:10.1007/ ...
https://en.wikipedia.org/wiki/Mapuche_history
Arginine catabolic mobile elementArginine catabolic mobile element
The arginine catabolic mobile element (ACME) is a mobile genetic element of Staphylococcus bacterial species. This genetic ... "The Arginine Catabolic Mobile Element and Staphylococcal Chromosomal Cassette Linkage: Convergence of Virulence and Resistance ... Mobile genetic elements Otto, Michael (August 2013). "Community-associated MRSA: What makes them special?". International ... v t e (Molecular biology, Mobile genetic elements, All stub articles, Genetics stubs). ...
https://en.wikipedia.org/wiki/Arginine_catabolic_mobile_element
Cycling probe technologyCycling probe technology
Cleavage occurs at the RNA internucleotide linkages and results in dissociation of the probe from the target, thereby making it ... "Integrated microfluidic electrophoresis system for analysis of genetic materials using signal amplification methods". ...
https://en.wikipedia.org/wiki/Cycling_probe_technology
DNA damage theory of agingDNA damage theory of aging
Werner syndrome (WS), a premature aging condition in humans, is caused by a genetic defect in a RecQ helicase that is employed ... Specifically, Acharya noted that double-strand breaks and a "cross-linkage joining both strands at the same point is ... A-type lamins promote genetic stability by maintaining levels of proteins that have key roles in the DNA repair processes of ... Lu L, Jin W, Wang LL (2017). "Aging in Rothmund-Thomson syndrome and related RECQL4 genetic disorders". Ageing Res. Rev. 33: 30 ...
https://en.wikipedia.org/wiki/DNA_damage_theory_of_aging
Rosh PinnaRosh Pinna
... and Putative Quasi-Linkage". Genome Research. 10 (10): 1509-1531. doi:10.1101/gr.150300. PMID 11042150 - via genome.cshlp.org ... "Molecular Genetic Maps in Wild Emmer Wheat, Triticum dicoccoides: Genome-Wide Coverage, Massive Negative Interference, ...
https://en.wikipedia.org/wiki/Rosh_Pinna
GeneNetworkGeneNetwork
"Towards systems genetic analyses in barley: Integration of phenotypic, expression and genotype data into GeneNetwork". BMC ... Architecture of larger networks of traits Quantitative trait locus mapping and causal models of the linkage between sequence ... Manly's Map Manager QT mapping program to produce an online system for real-time genetic analysis. In early 2003, the first ... Massive collections of genetic, genomic, and phenotype data for large cohorts of individuals Sophisticated statistical analysis ...
https://en.wikipedia.org/wiki/GeneNetwork
Genetic Linkage on the macGenetic Linkage on the mac
... JMILLER%VXBIO.SPAN at STAR.STANFORD.EDU JMILLER%VXBIO.SPAN at STAR.STANFORD.EDU Fri Dec 7 15:11:07 ... According to the LINKAGE newsletter distributed by Jung Ott, there IS a macintosh version of LINKAGE available. You might want ... I am on the look-out for two types of computer programs, ,preferably ftp-able from some site: , 1) Programs for linkage ...
http://bio.net/hypermail/BIO-SOFTWARE/1990-December/002072.html
Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology:...Pedigree with frontotemporal lobar degeneration--motor neuron disease and Tar DNA binding protein-43 positive neuropathology:...
Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. ... Re-analysis of linkage data using the new affection status revealed a maximal two-point LOD score of 3.24 and a multipoint LOD ... Linkage to chromosome 9p had been reported for pedigrees with the neurodegenerative disorder, frontotemporal lobar degeneration ... Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease ...
https://www.garvan.org.au/research/publications/10056
Why have genetic linkage studies of schizophrenia failed?
... their specific findings and the real genetic architecture of the disorder. The idea of genetic linkage studies is that if you ... Feel free to check my new blog out for some discussion of specific genetic linkage studies. It is a work in progress, but I ... Each time a new genetic linkage study comes out, it is often front page news that gene for schizophrenia has been found. We ... I would say that 3 decades of failed genetic linkage studies should at least raise the question of whether genes have anything ...
http://www.wiringthebrain.com/2012/08/why-have-genetic-linkage-studies-of.html?showComment=1388150528636
A genetic linkage map of lentil (Lens sp.) based on RAPD and AFLP markers using recombinant inbred lines<...
A genetic linkage map of lentil (Lens sp.) based on RAPD and AFLP markers using recombinant inbred lines. In: Theoretical and ... A genetic linkage map of lentil (Lens sp.) based on RAPD and AFLP markers using recombinant inbred lines. / Eujayl, I; Baum, M ... Eujayl I, Baum M, Powell W, Erskine W, Pehu E. A genetic linkage map of lentil (Lens sp.) based on RAPD and AFLP markers using ... Eujayl, I., Baum, M., Powell, W., Erskine, W., & Pehu, E. (1998). A genetic linkage map of lentil (Lens sp.) based on RAPD and ...
https://research-repository.uwa.edu.au/en/publications/a-genetic-linkage-map-of-lentil-lens-sp-based-on-rapd-and-aflp-ma
Ricki Lewis - Genetic Linkage
Genetic Linkage Pandemic Too Fast to Follow as Three Waves of Infection Wash Over the US: Delta, Omicron, and Flu December 18, ... Genetic material is well known to flit from genome to genome, crossing what we humans call species boundaries. But there are ... An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all. ...
https://www.rickilewis.com/blog/posts/40002
A study of genetic linkage heterogeneity in adult polycystic kidney disease. - SCNi
Such genetic heterogeneity of linkage would invalidate the general use of chromosome 16 markers for the purposes of detection ... No evidence was found to suggest heterogeneity of genetic linkage between alpha-globin and the APKD locus in this population. ... has previously been localised to chromosome 16 by the demonstration of genetic linkage with the loci for the alpha-chain of ... on only nine families so that the possibility remained that mutations at other genetic loci might produce the disease. ...
https://www.scni.ox.ac.uk/publications/560747
Pleiotropy or linkage? Their relative contributions to the genetic correlation of quantitative traits and detection by multi...
... simulations with four different genetic architectures to compare how pleiotropy and linkage differentially affect the genetic ... A fourth genetic architecture consisted of 120 unlinked, additive, pleiotropic loci that affected both quantitative traits. ... To examine the effects of mutational input on genetic correlation between traits, different sets of simulations were run with ... To examine the effects of migration from a source population on genetic correlation between traits, additional sets of ...
https://zenodo.org/record/3370185
Construction of genetic linkage map and identification of a novel major locus for resistance to pine wood nematode in Japanese...
The linkage map of Tanabe 54 consisted of 167 loci, and covered 14 linkage groups (LGs), with a total genetic distance of ... The linkage map of Tanabe 54 consisted of 167 loci, and covered 14 linkage groups (LGs), with a total genetic distance of ... The linkage map of Tanabe 54 consisted of 167 loci, and covered 14 linkage groups (LGs), with a total genetic distance of ... The linkage map of Tanabe 54 consisted of 167 loci, and covered 14 linkage groups (LGs), with a total genetic distance of ...
https://kyushu-u.pure.elsevier.com/ja/publications/construction-of-genetic-linkage-map-and-identification-of-a-novel
Using disease symptoms to improve detection of linkage under genetic heterogeneity. | Centre de recherche CERVOUsing disease symptoms to improve detection of linkage under genetic heterogeneity. | Centre de recherche CERVO
Adult, Autistic Disorder, Child, Genetic Heterogeneity, Genetic Linkage, Genetic Predisposition to Disease, Humans, Models, ... Using disease symptoms to improve detection of linkage under genetic heterogeneity.. Publication Type:. Journal Article ... In this paper, we propose approaches to use the resulting latent class probabilities in linkage analysis. We present results ... In an analysis of autism symptoms in families from the Autism Genetics Research Exchange, linkage signals obtained with latent ...
https://cervo.ulaval.ca/fr/using-disease-symptoms-improve-detection-linkage-under-genetic-heterogeneity
Category:Genetics - WikipediaCategory:Genetics - Wikipedia
... analysis of genetic interactions. Within organisms, genetic information generally is carried in chromosomes, where it is ... and counseling patients with genetic disorders. Humans began applying knowledge of genetics in prehistory with the ... Genetic linkage analysis‎ (3 P). M. *. Mobile genetic elements‎ (2 C, 49 P) ...
https://en.wikipedia.org/wiki/Category:Genetics
Construction of a genetic linkage map and QTL analysis of erucic acid content and glucosinolate components in yellow mustard ...Construction of a genetic linkage map and QTL analysis of erucic acid content and glucosinolate components in yellow mustard ...
The linkage map based on ILP and SSR markers was constructed and used for QTL analysis of seed quality traits in yellow mustard ... The constructed map covered a total genetic length of 890.4 cM with an average marker interval of 3.3 cM. The QTL for ... A total of 250 ILP and 14 SSR markers were mapped on 12 linkage groups and designated as Sal01-12 in yellow mustard. ... applicability of ILP markers from Brassica species and Arabidopsis makes them possible to be used for genetic linkage mapping ...
https://bmcplantbiol.biomedcentral.com/articles/10.1186/1471-2229-13-142/tables/4
Genetic linkage mapping of economically important traits in cultivated tetraploid potato (<i>Solanum tuberosum</i...
Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L.). In: G3: Genes ... Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L.). G3: Genes , ... Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L.). / Massa, ... Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L.). ...
https://discovery.dundee.ac.uk/en/publications/genetic-linkage-mapping-of-economically-important-traits-in-culti
Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans...Similar patterns of genetic diversity and linkage disequilibrium in Western chimpanzees (Pan troglodytes verus) and humans...
... the levels of genetic diversity and linkage disequilibrium observed in contemporary chimpanzees were globally similar to those ... we analysed several indexes of genetic diversity and linkage disequilibrium across seven MHC genes on four cohorts of ... and both significant global linkage disequilibrium and the greatest proportions of haplotypes in linkage disequilibrium were ... A reduction of genetic diversity at major histocompatibility complex (MHC) genes may have dramatic effects on populations ...
https://bmcecolevol.biomedcentral.com/articles/10.1186/s12862-020-01669-6/tables/6
Integrated Mechanical and Thermodynamic Optimization of an Engine Linkage Using a Multi-Objective Genetic Algorithm | J. Mech....Integrated Mechanical and Thermodynamic Optimization of an Engine Linkage Using a Multi-Objective Genetic Algorithm | J. Mech....
Integrated Mechanical and Thermodynamic Optimization of an Engine Linkage Using a Multi-Objective Genetic Algorithm Thomas A. ... "Integrated Mechanical and Thermodynamic Optimization of an Engine Linkage Using a Multi-Objective Genetic Algorithm." ASME. J. ... In order to improve the thermodynamic efficiency of an internal combustion engine (ICE), a Stephenson-III six-bar linkage is ... Synthesis of Quasi-Constant Transmission Ratio Planar Linkages J. Mech. Des (October,2015) ...
https://manufacturingscience.asmedigitalcollection.asme.org/mechanicaldesign/article-abstract/137/2/024501/376162/Integrated-Mechanical-and-Thermodynamic?searchresult=1
Colonial bentgrass genetic linkage mapping.Colonial bentgrass genetic linkage mapping.
... David Rotter1, Scott Warnke2, Stacy A. Bonos1, William Meyer1, and Faith Belanger3 ... Our progress in generating a colonial bentgrass genetic linkage map will be presented. ... we are developing a genetic linkage map of colonial bentgrass. We are using both AFLPs and gene-based markers for map ... Back to Genetic and Disease Evaluation of Turfgrasses. Back to C05 Turfgrass Science. Back to The ASA-CSSA-SSSA International ...
https://crops.confex.com/crops/2006am/techprogram/P24791.HTM
Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. - Radcliffe Department of...Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. - Radcliffe Department of...
... suggesting that haplotype structure is influenced by factors other than genetic drift, including both selection and ... Detailed knowledge of linkage disequilibrium (LD) is regarded as a prerequisite for population-based disease gene mapping. ... Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. ... Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. ...
https://www.rdm.ox.ac.uk/publications/135340
Episode Sixty-One | Just Genetic Marker Linkages - ForensicRTIEpisode Sixty-One | Just Genetic Marker Linkages - ForensicRTI
Episode Sixty-One , Just Genetic Marker Linkages. Lauren Mangum2018-09-10T12:44:49-04:00 Just Genetic Marker Linkages. In the ... He is the first author of a recent study on LD-based genetic record linkage (Edge et al., 2017, PNAS), which he conducted while ... Michael Edge of UC Davis about his research with record linkage of CODIS profiles with SNP genotypes. ... Just science discusses with Doc the possibilities of linkages between CODIS and SNPs databases for identity and familial ...
https://forensicrti.org/jss5-e6/
Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated...Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated...
Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated ... Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated ... A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab. ... A comparative short tandem repeat analysis revealed genetic similarities to a previous healthy gestation seventeen years prior ...
https://scholarshare.temple.edu/handle/20.500.12613/8114?show=full
A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21
This study has identified eight genomic locations with linkage of LOD , 2.0. This data should be of value in assisting ... Studies of QUS in twins have shown that both derived parameters are under substantial genetic control, independent of BMD. ... Multipoint linkage analyses provided maximum evidence of linkage for BUA (LOD 2.1-5.1) to 2q33-37. Linkage for VOS (LOD 2.2-3.4 ... A genome-screen of a large twin cohort reveals linkage for quantitative ultrasound of the calcaneus to 2q33-37 and 4q12-21 J ...
https://pubmed.ncbi.nlm.nih.gov/14969397/?dopt=Abstract
A Genetic Linkage Study of Gilles de la Tourette Syndrome | Global Research ProjectsA Genetic Linkage Study of Gilles de la Tourette Syndrome | Global Research Projects
We are continuing our systematic screening of the autosomal genome for strong evidence of a genetic linkage between a major ... Home » Neurology and Mental Health » A Genetic Linkage Study of Gilles de la Tourette Syndrome ... both typing of additional markers and re-analysis of all existing marker data using revised/updated diagnoses and genetic ...
https://globalprojects.ucsf.edu/project/genetic-linkage-study-gilles-de-la-tourette-syndrome
Genetic isolates in Corsica (France): linkage disequilibrium extension analysis on the Xq13 region
... LATINI, VERONICA;Sole G; ... In these populations, the disease allele reveals linkage disequilibrium (LD) with markers over significant genetic intervals, ... In these populations, the disease allele reveals linkage disequilibrium (LD) with markers over significant genetic intervals, ... Genetic isolates with a history of a small founder population, long-lasting isolation and population bottlenecks represent ...
https://iris.unica.it/handle/11584/108131
IMSEAR at SEARO: Construction of genetic linkage map of the medicinal and ornamental plant Catharanthus roseus.
An integrated genetic linkage map of the medicinal and ornamental plant Catharanthus roseus, based on different types of ... Gupta S, Pandey-Rai S, Srivastava S, Naithani SC, Prasad M, Kumar S. Construction of genetic linkage map of the medicinal and ... Construction of genetic linkage map of the medicinal and ornamental plant Catharanthus roseus. ... Linkage was observed between the morphological markers concerned with lamina shape and petiole size of leaf on LG1 and leaf, ...
https://imsear.searo.who.int/handle/123456789/114410?locale=es
Rapid Constructing a Genetic Linkage Map by AFLP Technique and Mapping a New Gene]tms5
... JIA Jian-Hang, LI Chuan-You, DENG Qi-Yun ... Rapid Constructing a Genetic Linkage Map by AFLP Technique and Mapping a New Gene]tms5[J]. J Integr Plant Biol., 2003, 45(5): ... An F2 population from the cross between Annong S-1 and Nanjing 11 was used to construct a genetic linkage map of rice. Total of ... In this study, we reported the repaid construction of a molecular marker linkage map of rice (Oryza sativa L.). ...
https://www.jipb.net/EN/abstract/abstract25262.shtml
Potential Pathway for Rare Neurological Disorder DiscoveredPotential Pathway for Rare Neurological Disorder Discovered
Childhood Form of ALS Discovered, Genetic Linkages Revealed. Molecule Expressed from Noncoding Genome Region Linked to Tumor ...
https://www.genengnews.com/news/potential-pathway-for-rare-neurological-disorder-discovered/
Are humans putting too much emphasis on genetic linkages in cancer research?Are humans putting too much emphasis on genetic linkages in cancer research?
... maybe as a result of the relative simplicity with which scientists are able to perform genetic cancer research, practically ... Are humans putting too much emphasis on genetic linkages in cancer research?. Obianuju Chukwu November 11, 2021. Breast Cancer ... Due to the fact that associations do not often imply true causal linkages, much of this research may be useless statistical ... In part, maybe as a result of the relative simplicity with which scientists are able to perform genetic cancer research, ...
https://www.nccmed.com/are-humans-putting-too-much-emphasis-on-genetic-linkages-in-cancer-research/
Frontiers | Proso Millet (Panicum miliaceum L.) and Its Potential for Cultivation in the Pacific Northwest, U.S.: A ReviewFrontiers | Proso Millet (Panicum miliaceum L.) and Its Potential for Cultivation in the Pacific Northwest, U.S.: A Review
SNP Markers, Genetic Linkage Map and Next-Generation Sequencing. Rajput et al. (2016) constructed the first genetic linkage map ... 833 SNPs were eventually used to construct the linkage map which has 18 linkage groups. Since this is the first genetic map for ... With the construction of the first genetic linkage map using SNPs and the first QTL mapping study conducted in proso millet ( ... genetic linkage analysis, genome-wide association studies and genomic selection in proso millet are now distinct possibilities ...
https://www.frontiersin.org/articles/10.3389/fpls.2016.01961/full
Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case - New...Wastewater Testing and Detection of Poliovirus Type 2 Genetically Linked to Virus Isolated from a Paralytic Polio Case - New...
Genetic linkage to Rockland County patient§. Unknown¶. No. Yes. Nassau. 4. 84.6. Mar 9-Oct 6. 1. 87. 2. 1. 0. 0. 1. 84. ... High-quality sequences are needed to characterize the virus and confirm linkages between viruses. Because the total number of ... Some samples had sequencing insufficient to determine relation to the Rockland County patient (i.e., linkage to patient unknown ... nucleotide differences is small, a single nucleotide change can be critical in confirming a linkage between viruses. Second, ...
https://www.cdc.gov/mmwr/volumes/71/wr/mm7144e2.htm
QTL mapping for microtuber dormancy and GA3 content in a diploid potato population | Biology Open | The Company of BiologistsQTL mapping for microtuber dormancy and GA3 content in a diploid potato population | Biology Open | The Company of Biologists
Genetic linkage map construction. In total, 134 primer pairs were used to amplify 182 polymorphic bands, averaging 1.35 bands ... Paternal linkage map construction and QTL analysis. To construct a linkage map of the long dormancy paternal parent PI 320285, ... A linkage map was constructed based on the paternal specific markers, which consisted of 12 linkage groups that could be ... JoinMap ®4, Software for the Calculation of Genetic Linkage Maps in Experimental Populations ...
https://journals.biologists.com/bio/article/7/1/bio027375/1595/QTL-mapping-for-microtuber-dormancy-and-GA3
DisequilibriumLociGenesMarkersGeneticsAnalysesVariationHeterogeneityRecombinationPolymorphismTraitsHumansChromosomesSNPsAllelesAnalysisLocusGenome-wideDiseasesPopulationsDiversityMutationGenomicFamiliesVariantsAllelePhenotypeAbstract2018PolymorphismsStudyDrosophilaDisordersBehaviorEtiologyStrainsApproachesSusceptibilityGenomesSpeciesComparativeResistanceDataStudiesSeventeenClinicalInherited genetic factors
Disequilibrium7
  • When we confi ned analysis to samples from northeast- the summers of 2004, 2005, 2006, and 2007, as described ern states, we confi rmed linkage disequilibrium between ospC and IGS1 loci ( 7 , 10 , 14 ). (cdc.gov)
  • Haplotype-specific linkage disequilibrium patterns define the genetic topography of the human MHC. (ox.ac.uk)
  • Detailed knowledge of linkage disequilibrium (LD) is regarded as a prerequisite for population-based disease gene mapping. (ox.ac.uk)
  • In these populations, the disease allele reveals linkage disequilibrium (LD) with markers over significant genetic intervals, therefore facilitating disease locus identification. (unica.it)
  • The global level of linkage disequilibrium was 3.4 cM. (biomedcentral.com)
  • In 5 cases, CNVs located were in strong linkage disequilibrium with tag SNPs, either within or adjacent to the same haplotype block. (usda.gov)
  • The development of linkage disequilibrium (LD) maps is very important for understanding the nature of non-linear association between phenotypes and genes, as LD can be defined as the non-random segregation of a pair of alleles at polymorphic sites. (embrapa.br)
Loci17
  • More than one-fourth of the distorted loci were clustered in one linkage group. (edu.au)
  • The mutation for adult polycystic kidney disease (APKD) has previously been localised to chromosome 16 by the demonstration of genetic linkage with the loci for the alpha-chain of haemoglobin and phosphoglycolate phosphatase. (ox.ac.uk)
  • These studies were carried out, however, on only nine families so that the possibility remained that mutations at other genetic loci might produce the disease. (ox.ac.uk)
  • Three different sets of genetic architecture had varying distances between 120 pairs of additive loci affecting two quantitative traits. (zenodo.org)
  • Each pair of loci was located on its own chromosome (i.e., unlinked to other pairs) and the recombination distance between each pair on a chromosome was either 0cM, 0.1cM, or 1cM apart for a particular genetic architecture representing no recombination between linked loci, as well as an average and an extreme value of recombination at ``hotspots'' in the human genome, respectively. (zenodo.org)
  • A fourth genetic architecture consisted of 120 unlinked, additive, pleiotropic loci that affected both quantitative traits. (zenodo.org)
  • Constructing a detailed linkage map of DNA markers and identifying PWD resistance genes/loci lead to improved resistance in Pinus thunbergii, as well as other Pinus species that are also susceptible to PWD. (elsevier.com)
  • The linkage map of 'Tanabe 54' consisted of 167 loci, and covered 14 linkage groups (LGs), with a total genetic distance of 1214.6 cM. (elsevier.com)
  • The linkage map of 'Tosashimizu 63' consisted of 252 loci, and covered 14 LGs, with a total genetic distance of 1422.1 cM. (elsevier.com)
  • Results from quantitative trait loci (QTL) analysis using phenotype data and linkage maps indicated that PWN resistance is controlled by a single dominant allele, which was derived from the 'Tanabe 54' female parent. (elsevier.com)
  • The objective of this study was to construct a single nucleotide polymorphism (SNP)-based genetic map at the cultivated tetraploid level to locate quantitative trait loci (QTL) contributing to economically important traits in potato (Solanum tuberosum L.). The 156 F1 progeny and parents of a cross (MSL603) between "Jacqueline Lee" and "MSG227-2" were genotyped using the Infinium 8303 Potato Array. (dundee.ac.uk)
  • The significance of such a segmented genome and the apparent potential for variation in genetic recombination will be relevant to haplotype stability and the longevity of future anticoccidial strategies based upon multiple loci targeted by novel chemotherapeutic drugs or recombinant subunit vaccines. (ox.ac.uk)
  • A high-density linkage map is a valuable tool for fine mapping quantitative trait loci (QTL) and map-based gene cloning. (rosaceae.org)
  • Genome-wide association studies (GWAS) is a useful tool to uncover genetic association with disease of interest, while linkage analysis is a commonly used method to identify statistical association between the inheritance of a human disease and inheritance of marker loci that are in linkage with disease causing loci. (scirp.org)
  • Linkage analysis is a commonly used method to identify statistical association between the inheritance of a human disease and inheritance of marker loci before the era of GWAS. (scirp.org)
  • 10.4194/1303-2712-v19_11_08 Viewed : 2359 - Downloaded : 1936 In the present study, 43 quantitative trait loci (QTL) associated with body length and body weight were identified based on the high density genetic map of O. potamophila composed of 6,311 SLAF markers. (trjfas.org)
  • Much attention has been paid to the identification of quantitative trait loci (QTL) associated with milk, fat, and protein yield and the genetic and molecular mechanisms underlying them. (usda.gov)
Genes11
  • Screening of all candidate genes within this region did not reveal any novel genetic alterations that co-segregate with disease haplotype, suggesting that one individual carrying a meiotic recombination may represent a phenocopy. (garvan.org.au)
  • An ideal starting point for anyone who wants to know more about genes, DNA, genomes, and the genetic ties that bind us all. (rickilewis.com)
  • Genetics is the study of genes , heredity , and the variation of organisms , as well as the medical practice of diagnosing, treating, and counseling patients with genetic disorders . (wikipedia.org)
  • Suggestive linkage of QUS parameters to 2q33-37 and 4q12-21 highlighted these regions as potentially important for studies of genes that regulate bone. (nih.gov)
  • Genetic isolates with a history of a small founder population, long-lasting isolation and population bottlenecks represent exceptional resources in the identification of genes involved in the pathogenesis of multifactorial diseases. (unica.it)
  • The clinical severity of β-thalassemia syndromes is also influenced by genetic factors unlinked to globin genes as well as environmental conditions and management. (nature.com)
  • The pattern of inheritance of genes conferring resistance to malathion and genetic consequences of linkage between an autosomal male-determining factor and resistance genes on the second chromosome were investigated in a strain of house fly, Musca domestica L., selected for malathion resistance. (metu.edu.tr)
  • Asociación hereditaria de dos o más GENES no alélicos debido a que están situados más o menos cerca en el mismo CROMOSOMA. (bvsalud.org)
  • In several other vertebrates, part of that individual variation in recombination rate (in the gametes passed on by that individual) is genetic, and associated with regions close to known meiosis-genes. (onunicornsandgenes.blog)
  • Genetic subdivision and candidate genes under selection in North American grey wolves. (princeton.edu)
  • In several high-ranking candidate genes, including LEPR, TYR and SLC14A2, we found variation in allele frequencies that follow environmental changes in temperature and precipitation, a result that is consistent with local adaptation rather than genetic drift. (princeton.edu)
Markers14
  • Genetic linkage and haplotype analyses, defined a critical region between markers D9S169 and D9S1845 on chromosome 9p21. (garvan.org.au)
  • The idea of genetic linkage studies is that if you have a disease segregating in a particular family, you can use neutral genetic markers across the genome to look at the inheritance of different segments of chromosomes through the pedigree and track which ones co-segregate with the disease. (wiringthebrain.com)
  • Such genetic heterogeneity of linkage would invalidate the general use of chromosome 16 markers for the purposes of detection of the disease, and complicate the characterisation of APKD at the molecular level. (ox.ac.uk)
  • The resulting genetic maps contained 1972 SNP markers with an average density of 1.36 marker per cM. (dundee.ac.uk)
  • An integrated genetic linkage map of the medicinal and ornamental plant Catharanthus roseus, based on different types of molecular and morphological markers was constructed, using a F(2) population of 144 plants. (who.int)
  • Linkage was observed between the morphological markers concerned with lamina shape and petiole size of leaf on LG1 and leaf, stem and petiole pigmentation and pod size on LG8. (who.int)
  • We are continuing our systematic screening of the autosomal genome for strong evidence of a genetic linkage between a major locus for Gilles de la Tourette Syndrome (GTS) and the simple Mendelian polymorphic markers that we are typing. (ucsf.edu)
  • This work will involve both typing of additional markers and re-analysis of all existing marker data using revised/updated diagnoses and genetic models. (ucsf.edu)
  • The development of a genetic map for E. maxima, presented here based upon 647 amplified fragment length polymorphism markers typed from 22 clonal hybrid lines and assembled into 13 major linkage groups, is a major new resource for work with this parasite. (ox.ac.uk)
  • Conversion of ∼14% of the markers representing the major linkage groups to sequence characterised amplified region markers can provide a scaffold for the assembly of future genomic sequences as well as providing a foundation for more detailed genetic maps. (ox.ac.uk)
  • Comparison with the Eimeria tenella genetic map produced 10years ago has revealed a less biased marker distribution, with no more than nine markers mapped within any unresolved heritable unit. (ox.ac.uk)
  • The linkage map consists of 3143 SNP markers and 98 SSRs, 3241 markers in total, spanning 2243.4 cM, with an average marker distance of 0.70 cM. (rosaceae.org)
  • In contrast, a highly significant linkage was detected with a number of markers located in the vicinity of the type I keratin gene cluster on band 17q21, with maximum 2-lod scores of 4.16 and 3.717 for the markers D17S1787 and D17S1886, respectively. (medscape.com)
  • [ 4 ] The genetic defect appears to be a region of the gene encoding the KRT14 nonhelical head (E1/V1) domain located between the microsatellite markers D17S798 and D17S957, which are separated by approximately 26.97 cM. (medscape.com)
Genetics7
  • In an analysis of autism symptoms in families from the Autism Genetics Research Exchange, linkage signals obtained with latent class-derived phenotypes were stronger than those obtained using the original autism spectrum disorder diagnosis. (ulaval.ca)
  • In modern research, genetics provides important tools in the investigation of the function of a particular gene, e.g. analysis of genetic interactions . (wikipedia.org)
  • The well characterised immunogenicity and genetic diversity associated with E. maxima promote its use in genetics-led studies on avian coccidiosis. (ox.ac.uk)
  • This was a 3-year Training Fellowship in the UCLA Intercampus Medical Genetics Training Program and the project involved the genetic mapping of PSACH and MED mutations in large families with these diseases. (ncl.ac.uk)
  • Postdoc Sarah Earle continues research into pathogen genetic risk factors for diseases including tuberculosis and meningococcal meningitis, while Steven Lin has continued to pursue work on hepatitis C virus genetics and epidemiology. (me.uk)
  • There was a considerable genetic component to many of them, with genetics accounting for 25 percent or more of the variations in human sociability, toy-directed behavior, ability and interest in responding to orders, among other traits. (nwctrail.com)
  • Genetic studies in tetraploids are lagging behind in comparison with studies of diploids as the complex genetics of tetraploids require much more elaborated computational methodologies. (biomedcentral.com)
Analyses5
  • Linkage analyses and QTL mapping were performed using a novel approach that incorporates allele dosage information. (dundee.ac.uk)
  • Multipoint linkage analyses provided maximum evidence of linkage for BUA (LOD 2.1-5.1) to 2q33-37. (nih.gov)
  • Toutefois, après une étude plus approfondie des cas ayant des parentes au premier et second degré touchées, nous avons observé une différence significative entre le pourcentage de patientes positives pour les grands réarrangements génomiques sur le gène BRCA1 et celui des patientes dont les analyses étaient négatives en la matière. (who.int)
  • We conclude that combining CNV with SNP analyses reveals more genetic variations underlying milk production traits than those revealed by SNPs alone. (usda.gov)
  • Along with groups at McGill and the Broad Institute , I have contributed analyses of UK Biobank to investigate genetic risk factors for COVID-19. (me.uk)
Variation14
  • Each simulation was run with 5,000 initially monomorphic (variation is gradually introduced through mutations), diploid individuals for 10,000 generations achieving mutation-selection(-migration) balance in order to observe general patterns of genetic correlation in the near-absence of drift. (zenodo.org)
  • The genome-wide association (GWA) approach represents an alternative to biparental linkage mapping for determining the genetic basis of trait variation. (biomedcentral.com)
  • To date only one GWA-based study of variation in eggplant has been performed [ 16 ] but the present study used a larger number of accessions (191 vs 141 ) and a more densely populated genetic map (384 SNPs (single nucleotide polymorphisms) vs 105 microsatellites) and targeted traits related to anthocyanin accumulation and fruit color. (biomedcentral.com)
  • 2003). Support for association of schizophrenia with genetic variation in the 6p22.3 gene, dysbindin, in sib-pair families with linkage and in an additional sample of triad families. (bvsalud.org)
  • Our paper on genetic variation in recombination in the pig just came out the other week. (onunicornsandgenes.blog)
  • The effect of genetic variation on promoter usage and enhancer activity. (coriell.org)
  • Adaptation requires genetic variation, but founder populations are generally genetically depleted. (wurmlab.com)
  • Depletion of genetic variation is detrimental to species evolution and adaptation 1 . (wurmlab.com)
  • Low genetic and phenotypic variation is common in founder populations, where only one or a few genotypes are isolated from a source population. (wurmlab.com)
  • This raises the question of how genetic variation as the raw material for adaptation is generated in such systems. (wurmlab.com)
  • Under such conditions, genetic drift is predicted to drastically deplete genetic variation, thus leaving little for selection to act on. (wurmlab.com)
  • We find clear phenotypic differences between the populations and strong correlation between accumulations of TEs ('TE islands') and genetic variation. (wurmlab.com)
  • Dermatopathia pigmentosa reticularis, allelic to NFJ, shares many features and may be a variation of the same genetic defect, but is distinguished by alopecia, reticulate pigmentation that lasts into adulthood, and the lack of dental abnormalities. (medscape.com)
  • 2014) Geographical and environmental gradients shape phenotypic trait variation and genetic structure in Populus trichocarpa . (wikidot.com)
Heterogeneity8
  • A study of genetic linkage heterogeneity in adult polycystic kidney disease. (ox.ac.uk)
  • No evidence was found to suggest heterogeneity of genetic linkage between alpha-globin and the APKD locus in this population. (ox.ac.uk)
  • Using disease symptoms to improve detection of linkage under genetic heterogeneity. (ulaval.ca)
  • This has not been demonstrated in most families with Paget disease, however, which suggests genetic heterogeneity. (medscape.com)
  • We propose a likelihood ratio test for genome-wide linkage analysis under genetic heterogeneity using family data. (scirp.org)
  • Our extensive simulation studies indicate that the proposed test has proper type I error and good power under genetic heterogeneity. (scirp.org)
  • In order to simplify application of the proposed method for non-statisticians, we develop an R package gLRTH to implement the proposed LRT for genome-wide linkage analysis as well as Qian and Shao's LRT for GWAS under heterogeneity. (scirp.org)
  • However, the standard GWAS analysis methods ignore the widely existing genetic heterogeneity. (scirp.org)
Recombination4
  • Strong and extensive LD is found across both common and rare haplotypes, suggesting that haplotype structure is influenced by factors other than genetic drift, including both selection and differential haplotype recombination. (ox.ac.uk)
  • Comparison with genetic maps produced for other coccidial parasites indicates relatively high levels of genetic recombination. (ox.ac.uk)
  • The major advantages of GWA over biparental linkage mapping lie in the much wider variability in phenotype and genotype made accessible, a history of multiple rounds of recombination in many different lineages and the inclusion of germplasm of direct relevance to crop improvement. (biomedcentral.com)
  • Recombination between chromosomes during meiosis leads to shuffling of genetic material between chromosomes, creating new combinations of alleles. (onunicornsandgenes.blog)
Polymorphism1
  • Whole genome resequencing can identify DNA biomarkers such as single nucleotide polymorphism (SNPs), insertions and deletions (indels), structure variations (SVs), copy number variations (CNVs) and other genetic changes of the sequenced species with high accuracy. (cd-genomics.com)
Traits13
  • Their relative contributions to the genetic correlation of quantitative traits and detection by multi-trait GWA studies. (zenodo.org)
  • Results from simulations with four different genetic architectures to compare how pleiotropy and linkage differentially affect the genetic correlation between traits. (zenodo.org)
  • To examine the effects of mutational input on genetic correlation between traits, different sets of simulations were run with mutation rates of 0.001, 0.0001, or 0.00001, and mutational effect sizes of 0.1, 0.01, or 0.001. (zenodo.org)
  • To examine the effects of migration from a source population on genetic correlation between traits, additional sets of simulations were run with uni-directional migration from a second population (as in an island-mainland model with each population consisting of 5000 individuals) with backward migration rates of 0.1, 0.01, and 0.001. (zenodo.org)
  • Genetic linkage mapping of economically important traits in cultivated tetraploid potato (Solanum tuberosum L. (dundee.ac.uk)
  • Dive into the research topics of 'Genetic linkage mapping of economically important traits in cultivated tetraploid potato ( Solanum tuberosum L.)'. Together they form a unique fingerprint. (dundee.ac.uk)
  • This high-density linkage map of pear is a worthy reference for mapping important fruit traits, QTL identification, and comparison and combination of different genetic maps. (rosaceae.org)
  • Graham King has developed and characterised a range of Brassica genetic and genomic resources underpinning crop improvement traits. (edu.au)
  • These have including reference mapping populations, linkage maps and detailed analysis of QTL for physiological and developmental traits, and resistance to diseases. (edu.au)
  • Advances in understanding the genetic basis of crop traits requires detailed knowledge of the complex genome structure of Brassica species. (edu.au)
  • It shows that the growth traits of O. potamophila were likely controlled by 10 QTLs distributed on three genetic linkage groups (LG4, LG6 and LG16). (trjfas.org)
  • Recombinant inbred strains were viewed as useful for evaluating the linkage between traits and determining chromosomal locations. (cdc.gov)
  • The genome-wide association (GWA) approach represents an alternative to biparental linkage mapping for the determination of the genetic basis of traits [ 12 ]. (biomedcentral.com)
Humans3
  • Genetic material is well known to flit from genome to genome, crossing what we humans call species boundaries. (rickilewis.com)
  • Are humans putting too much emphasis on genetic linkages in cancer research? (nccmed.com)
  • Because of this strategy, they discovered an entertaining result: "gets trapped behind things" was the individual behavior with the strongest genetic relationship, which they tracked down to a tiny section of the genome that has a gene connected with cognitive ability in humans. (nwctrail.com)
Chromosomes4
  • Within organisms , genetic information generally is carried in chromosomes , where it is represented in the chemical structure of particular DNA molecules . (wikipedia.org)
  • In other words, the linkage maps of the chromosomes are really summaries of many statistical observations on the outcomes of hybridization experiments. (britannica.com)
  • Anchoring SSRs were able to anchor seventeen linkage groups to their corresponding chromosomes. (rosaceae.org)
  • The homologous linkage groups on human chromosomes 9p2I, 1p36, 9q and 8q are altered in asbestos -induced human lung adenocarcinoma. (cdc.gov)
SNPs2
  • Just science discusses with Doc the possibilities of linkages between CODIS and SNPs databases for identity and familial matching, and dispel preconceptions associated with them. (forensicrti.org)
  • In this study, we firstly constructed a high-density linkage map of pear using SNPs integrated with SSRs, developed by the rapid and robust technology of restriction-associated DNA sequencing (RADseq). (rosaceae.org)
Alleles2
  • There is a fairly strong genetic background to pemphigus vulgaris with linkage to HLA class II alleles. (bvsalud.org)
  • Under such conditions, reduced effective population size (Ne) should decrease selection efficiency and increase genetic drift, resulting in only weak selection against mildly deleterious alleles which can thus accumulate 2 . (wurmlab.com)
Analysis17
  • Re-analysis of linkage data using the new affection status revealed a maximal two-point LOD score of 3.24 and a multipoint LOD score of 3.41 at marker D9S1817. (garvan.org.au)
  • In this paper, we propose approaches to use the resulting latent class probabilities in linkage analysis. (ulaval.ca)
  • Construction of a genetic linkage map and QTL analysis of erucic acid content and glucosinolate components in yellow mustard (Sinapis albaL. (biomedcentral.com)
  • A comparative short tandem repeat analysis revealed genetic similarities to a previous healthy gestation seventeen years prior. (temple.edu)
  • Due to the fact that associations do not often imply true causal linkages, much of this research may be useless statistical noise that makes productive analysis more challenging. (nccmed.com)
  • oncogene activation, mechanisms of signal transduction, and genetic linkage analysis. (cdc.gov)
  • Genetic linkage analysis to identify a gene required for the addition of phosphoethanolamine to meningococcal lipopolysaccharide. (ox.ac.uk)
  • Subsequent genetic linkage analysis was used to define a region of DNA containing a single intact open reading frame which is sufficient to confer B5 reactivity to a B5 negative meningococcal isolate. (ox.ac.uk)
  • The genome-wide association study (GWAS) and linkage analysis are two classical approaches for studying human genetic disorders. (scirp.org)
  • Association analysis uses common variants and allows for finer mapping than linkage analysis in general. (scirp.org)
  • Linkage analysis again becomes important to identify causal variants using family-based deep sequencing data. (scirp.org)
  • We expect to recruit 400 responders for this genetic analysis. (cdc.gov)
  • A framework for analyzing both linkage and association: an analysis of Genetic Analysis Workshop 16 simulated data. (bvsalud.org)
  • A lifespan approach will be applied to a broad range of topics, including historical considerations, diagnostic issues, prevalence/incidence, profile of ASD including the triad of impairments, genetic linkages, cognitive processing and executive functioning, and evidence-informed interventions including an introduction to applied behavioural analysis and positive behavioural support models. (nipissingu.ca)
  • Using linkage mapping, transcriptome analysis, and genome editing, we identify csf1 as a causative gene for red pectoral fins that are unique to male Oryzias woworae. (archive.org)
  • This high-bone-mass trait (HBM) was originally localized by linkage analysis to chromosome 11q12-13. (elsevier.com)
  • One of Breeding Insight's aims is to accelerate breeding efforts by integrating the use of phenomics (trait analysis) with genomics and integrated web-based software to increase the rate of genetic gain to create healthy, nutritious, and sustainable specialty crops and animals. (academicjobsonline.org)
Locus3
  • 20 infected I. pacifi cus adults from Contra Costa County, Genetic Locus California (J. Bunikis and A.G. Barbour, unpub. (cdc.gov)
  • The objective in this study is to identify the genetic locus in a multi-generational Australian family with FTLD-MND. (garvan.org.au)
  • Linkage of pyrethroid insecticide resistance to a sodium-channel locus in the tobacco budworm. (mpg.de)
Genome-wide2
  • In the last two decades, linkage based gene mapping has been marginalized by the population-based genome-wide association study. (scirp.org)
  • What's more, whole genome re-sequencing is an indispensable part of genome-wide association study (GWAS), where common genetic variants in different individuals are assessed to determine if a variant is associated with a particular phenotype. (cd-genomics.com)
Diseases4
  • Where linkage studies of other diseases have been successful, those are the kinds of pedigrees that have been analysed. (wiringthebrain.com)
  • It is well known that common and complex human diseases usually have heterogeneous disease etiology, which often involves interplay of multiple genetic and environmental factors, leading to latent population substructure. (scirp.org)
  • Disruptions to these processes lead to growth plate dysplasia and result in a heterogeneous group of genetic diseases known as skeletal dysplasias that are characterised predominantly by short-limb dwarfism. (ncl.ac.uk)
  • Hartley CL, Edwards S, Mullan L, Bell PA, Fresquet M, Boot-Handford RP, Briggs MD. Armet/Manf and Creld2 are components of a specialized ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases . (ncl.ac.uk)
Populations5
  • Recent evidence has highlighted that the genetic proximity between the populations of Corsica and Sardinia is particularly true for the internal conservative populations. (unica.it)
  • Genetic variants in embryonic lethal, abnormal vision, Drosophila-like 4 (ELAVL4) have been reported to be associated with onset age of Parkinson disease (PD) or risk for PD affection in Caucasian populations. (healthpartners.com)
  • A direct assessment of the role of genetic drift in determining allele frequency in populations of Euphydryas editha. (mpg.de)
  • In spite of strong genetic bottlenecks, even single colonies with few reproductive individuals suffice to establish stable populations. (wurmlab.com)
  • Our results suggest that TE islands might function as spring wells for genetic diversification in founder populations of this invasive species. (wurmlab.com)
Diversity1
  • In a bi-parental population, only the polymorphisms between the two parents can be queried, whereas in a GWA population the number of polymorphisms is determined by the genetic diversity of the entire germplasm panel. (biomedcentral.com)
Mutation1
  • Heterogeneous Phenotype of Long QT Syndrome Caused by the KCNH2-H562R Mutation: Importance of Familial Genetic Testing. (cdc.gov)
Genomic1
  • The large amount of genetic information accumulated in the post-genomic era needs to be transformed into knowledge 1 . (nature.com)
Families3
  • It is true that many genetic linkage studies have been performed to look for mutations that are segregating with schizophrenia across multiple affected members in families. (wiringthebrain.com)
  • This is the first identification of CLCC1 as a cause of human disease and enables improved understanding of the molecules important for eye development and function, as well as providing a genetic diagnosis for families with RP. (plos.org)
  • Congenital heart defects run in families and may have a genetic linkage with disorders like the Down's syndrome. (verikshop.com)
Variants2
  • This argument is often trotted out in discussions of the genetic architecture of schizophrenia, which centre on the question of whether it is caused by rare, single mutations in most cases or whether it is due to unfortunate combinations of thousands of common variants segregating in the population. (wiringthebrain.com)
  • Legal, ethical issues loom over topic of recontacting patients: Advances in research, next-generation sequencing lead geneticists to consider approaching former patients with results about genetic variants. (cdc.gov)
Allele1
  • For 741 Ixodes ticks from northeastern and north-cen- the extent of genomewide genetic exchange in this spe- tral United States or from northern California, 1 ospC allele cies may have been underestimated ( 6 ). (cdc.gov)
Phenotype4
  • Another thing that is absolutely imperative for linkage studies to work is that you know you are looking at the right phenotype - you must be certain of the affected status of each member of the pedigree. (wiringthebrain.com)
  • Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. (nature.com)
  • Previous genetic studies of the highly mobile grey wolf (Canis lupus) found population structure that coincides with habitat and phenotype differences. (princeton.edu)
  • Genetic adaptation, heritable genetic change that improves the mean fitness of a population in an environment 5 , enables resilience by shifting the mean phenotype of the population to tolerate different conditions. (digitalmarylandnews.com)
Abstract1
  • abstract = "A genetic linkage map of Lens sp. (edu.au)
20181
  • In the sixth episode of the 2018 R&D Season, Just Science speaks with Dr. Michael Edge of UC Davis about his research with record linkage of CODIS profiles with SNP genotypes. (forensicrti.org)
Polymorphisms1
  • The creation of double congenic inbred strains for the study of two genetic polymorphisms was also addressed. (cdc.gov)
Study5
  • So, finding really large pedigrees where schizophrenia is clearly segregating across multiple generations has not been easy - in fact, there are very few reported that would be large enough by themselves to allow a highly powered linkage study. (wiringthebrain.com)
  • He is the first author of a recent study on LD-based genetic record linkage (Edge et al. (forensicrti.org)
  • In this study, we reported the repaid construction of a molecular marker linkage map of rice (Oryza sativa L.). An F2 population from the cross between Annong S-1 and Nanjing 11 was used to construct a genetic linkage map of rice. (jipb.net)
  • No genetic study has been reported in familial PKC up to now. (bmj.com)
  • A qualitative study on asymptomatic women living with genetic risk of breast/ovarian cancer. (cdc.gov)
Drosophila1
  • Alfred Sturtevant, one of Morgan's students, did most of the work on the Drosophila linkage maps. (dnaftb.org)
Disorders2
  • This is a particular problem for neuropsychiatric disorders, which we are now realising have highly overlapping genetic etiology . (wiringthebrain.com)
  • These mechanisms of transmission include genetic and neurobiological influences, fetal alcohol spectrum disorders, assortative mating (attraction of those exposed to parental addition to individuals who share this family history), co-occurring conditions, temperament, developmental and historical trauma, family dynamics (e.g., parental/sibling modeling and collusion), early age of alcohol and other drug (AOD) exposure, and disruption of family rituals. (facesandvoicesofrecovery.org)
Behavior1
  • The researchers compared the breed/behavior linkage of members of a breed to the same linkage in dogs randomly selected from the entire population in order to determine whether any of these behaviors were associated with specific breeds. (nwctrail.com)
Etiology1
  • Although the etiology of Paget disease is unknown, both genetic and environmental contributors have been suggested. (medscape.com)
Strains1
  • Advantages of inbred strains included the stability of strain characteristics, genetic reliability and homogeneity, and the elimination of genetic confounders. (cdc.gov)
Approaches1
  • Genome-wide approaches to epidermal function include short interfering RNA-based genetic screens in cultured human epidermal cells 8 and RNA interference-mediated gene knockdown via in utero microinjection of lentiviral vectors 9 . (nature.com)
Susceptibility1
  • Dr. Zarbl is known for his work in areas of toxicogenomics, and mechanisms of and genetic susceptibility to chemical carcinogenesis, mechanisms of mutagenesis and toxicity, and technology development. (cdc.gov)
Genomes1
  • The seven chromosome scaffolds were anchored to a previously published genetic linkage map with a high degree of synteny and comparisons to genomes of closely related species within the Rosoideae revealed chromosome-scale rearrangements that have occurred over relatively short evolutionary periods. (nibio.no)
Species2
  • At the same time, the combination of prolonged inbreeding with severe genetic bottlenecks strongly reduces Ne in this species. (wurmlab.com)
  • Genetic studies in tetraploid species are lagging behind those of diploids. (biomedcentral.com)
Comparative1
  • Comparative genetic linkage mapping in insects. (mpg.de)
Resistance1
  • As one approach to identifying the regions of the colonial bentgrass genome conferring dollar spot resistance, we are developing a genetic linkage map of colonial bentgrass. (confex.com)
Data5
  • In order for linkage studies to have power, you need to get data from many such transmissions and you therefore need big pedigrees - really huge pedigrees, actually, with information across multiple generations and preferably extending to lots of second or third degree relatives. (wiringthebrain.com)
  • Data for 'Pleiotropy or linkage? (zenodo.org)
  • For example, by extracting data from clinicians' notes and combining the results with protein and genetic information, Danish scientist Francisco Roque and his colleagues at Technical University of Denmark discovered hidden linkages between health problems that were believed to be unrelated, such as migraines and hair loss, or glaucoma and a hunching back. (the-scientist.com)
  • We have published a paper describing the dynamic data linkage in Microbial Genomics ( press release ). (me.uk)
  • It was paired with genetic data, including previously released genome sequences from more than 500 purebred dogs, to produce a comprehensive picture of the dogs' health. (nwctrail.com)
Studies6
  • Why have genetic linkage studies of schizophrenia failed? (wiringthebrain.com)
  • This depends very much on the details of how these studies were carried out, their underlying assumptions, their specific findings and the real genetic architecture of the disorder. (wiringthebrain.com)
  • Studies of QUS in twins have shown that both derived parameters are under substantial genetic control, independent of BMD. (nih.gov)
  • These results should complement genome screens of BMD and bone structure and serve to enable further targeted positional candidate and positional cloning studies to advance our understanding of genetic control of bone quality and risk of fracture. (nih.gov)
  • Some studies suggest a genetic linkage for Paget disease located on chromosome arm 18q. (medscape.com)
  • The historical approach to setting OELs has in- genetic information extensively, but to date such factors have not volved investigators observing workers as well transmitted between been used to protect workers by incorpora- as conducting laboratory and animal studies. (cdc.gov)
Seventeen1
  • Pisani D, Calleja-Agius J, Di Fiore R, O'Leary JJ, Beirne JP, O'Toole SA, Felix A, Said-Huntingford I. Epithelioid Trophoblastic Tumour: A Case with Genetic Linkage to a Child Born over Seventeen Years Prior, Successfully Treated with Surgery and Pembrolizumab. (temple.edu)
Clinical1
  • Case meets the clinical and epidemiologic linkage criteria. (cdc.gov)
Inherited genetic factors1
  • In this review, we focus primarily on inherited genetic factors and their role in occupational health standard setting. (cdc.gov)