Genetic engineering. Medical search

Directed modification of the gene complement of a living organism by such techniques as altering the DNA, substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc.

Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.

Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.

Methods and techniques used to genetically modify cells' biosynthetic product output and develop conditions for growing the cells as BIOREACTORS.

Body of knowledge related to the use of organisms, cells or cell-derived constituents for the purpose of developing products which are technically, scientifically and clinically useful. Alteration of biologic function at the molecular level (i.e., GENETIC ENGINEERING) is a central focus; laboratory methods used include TRANSFECTION and CLONING technologies, sequence and structure analysis algorithms, computer databases, and gene and protein structure function analysis and prediction.

PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.

Application of principles and practices of engineering science to biomedical research and health care.

The study of religion and religious belief, or a particular system or school of religious beliefs and teachings (from online Cambridge Dictionary of American English, 2000 and WordNet: An Electronic Lexical Database, 1997)

DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.

Change brought about to an organisms genetic composition by unidirectional transfer (TRANSFECTION; TRANSDUCTION, GENETIC; CONJUGATION, GENETIC, etc.) and incorporation of foreign DNA into prokaryotic or eukaryotic cells by recombination of part or all of that DNA into the cell's genome.

Cultivated plants or agricultural produce such as grain, vegetables, or fruit. (From American Heritage Dictionary, 1982)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

Hydrocarbon-rich byproducts from the non-fossilized BIOMASS that are combusted to generate energy as opposed to fossilized hydrocarbon deposits (FOSSIL FUELS).

Cell growth support structures composed of BIOCOMPATIBLE MATERIALS. They are specially designed solid support matrices for cell attachment in TISSUE ENGINEERING and GUIDED TISSUE REGENERATION uses.

Toxins isolated from the venom of Laticauda semifasciata, a sea snake (Hydrophid); immunogenic, basic polypeptides of 62 amino acids, folded by four disulfide bonds, block neuromuscular end-plates irreversibly, thus causing paralysis and severe muscle damage; they are similar to Elapid neurotoxins.

The use of genetic methodologies to improve functional capacities of an organism rather than to treat disease.

Compounds derived from TYROSINE via betalamic acid, including BETAXANTHINS and BETACYANINS. They are found in the Caryophyllales order of PLANTS and some BASIDIOMYCETES.

The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.

A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.

The integration of exogenous DNA into the genome of an organism at sites where its expression can be suitably controlled. This integration occurs as a result of homologous recombination.

Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.

Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.

The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.

Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.

Proteins prepared by recombinant DNA technology.

Proteins found in plants (flowers, herbs, shrubs, trees, etc.). The concept does not include proteins found in vegetables for which VEGETABLE PROTEINS is available.

Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.

The application of engineering principles and methods to living organisms or biological systems.

The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.

Anaerobic degradation of GLUCOSE or other organic nutrients to gain energy in the form of ATP. End products vary depending on organisms, substrates, and enzymatic pathways. Common fermentation products include ETHANOL and LACTIC ACID.

Methods and techniques used to modify or select cells and develop conditions for growing cells for biosynthetic production of molecules (METABOLIC ENGINEERING), for generation of tissue structures and organs in vitro (TISSUE ENGINEERING), or for other BIOENGINEERING research objectives.

Complex sets of enzymatic reactions connected to each other via their product and substrate metabolites.

The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.

A species of gram-negative, aerobic bacteria isolated from soil and the stems, leafs, and roots of plants. Some biotypes are pathogenic and cause the formation of PLANT TUMORS in a wide variety of higher plants. The species is a major research tool in biotechnology.

Self-replicating cytoplasmic organelles of plant and algal cells that contain pigments and may synthesize and accumulate various substances. PLASTID GENOMES are used in phylogenetic studies.

A genus of bacteria that form a nonfragmented aerial mycelium. Many species have been identified with some being pathogenic. This genus is responsible for producing a majority of the ANTI-BACTERIAL AGENTS of practical value.

A plant genus of the family SOLANACEAE. Members contain NICOTINE and other biologically active chemicals; its dried leaves are used for SMOKING.

Use of naturally-occuring or genetically-engineered organisms to reduce or eliminate populations of pests.

Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.

Catalyzes the decarboxylation of an alpha keto acid to an aldehyde and carbon dioxide. Thiamine pyrophosphate is an essential cofactor. In lower organisms, which ferment glucose to ethanol and carbon dioxide, the enzyme irreversibly decarboxylates pyruvate to acetaldehyde. EC 4.1.1.1.

Recombinases that insert exogenous DNA into the host genome. Examples include proteins encoded by the POL GENE of RETROVIRIDAE and also by temperate BACTERIOPHAGES, the best known being BACTERIOPHAGE LAMBDA.

Proteins found in any species of bacterium.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in plants.

Prolonged dry periods in natural climate cycle. They are slow-onset phenomena caused by rainfall deficit combined with other predisposing factors.

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

The most abundant natural aromatic organic polymer found in all vascular plants. Lignin together with cellulose and hemicellulose are the major cell wall components of the fibers of all wood and grass species. Lignin is composed of coniferyl, p-coumaryl, and sinapyl alcohols in varying ratios in different plant species. (From Merck Index, 11th ed)

Multicellular, eukaryotic life forms of kingdom Plantae (sensu lato), comprising the VIRIDIPLANTAE; RHODOPHYTA; and GLAUCOPHYTA; all of which acquired chloroplasts by direct endosymbiosis of CYANOBACTERIA. They are characterized by a mainly photosynthetic mode of nutrition; essentially unlimited growth at localized regions of cell divisions (MERISTEMS); cellulose within cells providing rigidity; the absence of organs of locomotion; absence of nervous and sensory systems; and an alternation of haploid and diploid generations.

The functional hereditary units of PLANTS.

ANIMALS whose GENOME has been altered by GENETIC ENGINEERING, or their offspring.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.

Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.

Artificial organs that are composites of biomaterials and cells. The biomaterial can act as a membrane (container) as in BIOARTIFICIAL LIVER or a scaffold as in bioartificial skin.

DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.

Substances found in PLANTS that have antigenic activity.

A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Process of generating a genetic MUTATION. It may occur spontaneously or be induced by MUTAGENS.

Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.

The encapsulated embryos of flowering plants. They are used as is or for animal feed because of the high content of concentrated nutrients like starches, proteins, and fats. Rapeseed, cottonseed, and sunflower seed are also produced for the oils (fats) they yield.

A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.

Water swollen, rigid, 3-dimensional network of cross-linked, hydrophilic macromolecules, 20-95% water. They are used in paints, printing inks, foodstuffs, pharmaceuticals, and cosmetics. (Grant & Hackh's Chemical Dictionary, 5th ed)

A field of biological research combining engineering in the formulation, design, and building (synthesis) of novel biological structures, functions, and systems.

Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.

Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.

Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.

A genus of gram-negative, aerobic, rod-shaped bacteria that activate PLANT ROOT NODULATION in leguminous plants. Members of this genus are nitrogen-fixing and common soil inhabitants.

The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide using energy obtained from light rather than from the oxidation of chemical compounds. Photosynthesis comprises two separate processes: the light reactions and the dark reactions. In higher plants; GREEN ALGAE; and CYANOBACTERIA; NADPH and ATP formed by the light reactions drive the dark reactions which result in the fixation of carbon dioxide. (from Oxford Dictionary of Biochemistry and Molecular Biology, 2001)

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.

The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.

A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).

Elimination of ENVIRONMENTAL POLLUTANTS; PESTICIDES and other waste using living organisms, usually involving intervention of environmental or sanitation engineers.

A field of medicine concerned with developing and using strategies aimed at repair or replacement of damaged, diseased, or metabolically deficient organs, tissues, and cells via TISSUE ENGINEERING; CELL TRANSPLANTATION; and ARTIFICIAL ORGANS and BIOARTIFICIAL ORGANS and tissues.

The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.

Tools or devices for generating products using the synthetic or chemical conversion capacity of a biological system. They can be classical fermentors, cell culture perfusion systems, or enzyme bioreactors. For production of proteins or enzymes, recombinant microorganisms such as bacteria, mammalian cells, or insect or plant cells are usually chosen.

The functional hereditary units of BACTERIA.

Motifs in DNA- and RNA-binding proteins whose amino acids are folded into a single structural unit around a zinc atom. In the classic zinc finger, one zinc atom is bound to two cysteines and two histidines. In between the cysteines and histidines are 12 residues which form a DNA binding fingertip. By variations in the composition of the sequences in the fingertip and the number and spacing of tandem repeats of the motif, zinc fingers can form a large number of different sequence specific binding sites.

A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.

Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.

The fertilizing element of plants that contains the male GAMETOPHYTES.

Deoxyribonucleic acid that makes up the genetic material of plants.

The science, art or practice of cultivating soil, producing crops, and raising livestock.

The relationships of groups of organisms as reflected by their genetic makeup.

Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.

The rate dynamics in chemical or physical systems.

Diseases of plants.

A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.

Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.

The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.

Cells derived from the BLASTOCYST INNER CELL MASS which forms before implantation in the uterine wall. They retain the ability to divide, proliferate and provide progenitor cells that can differentiate into specialized cells.

A phylum of oxygenic photosynthetic bacteria comprised of unicellular to multicellular bacteria possessing CHLOROPHYLL a and carrying out oxygenic PHOTOSYNTHESIS. Cyanobacteria are the only known organisms capable of fixing both CARBON DIOXIDE (in the presence of light) and NITROGEN. Cell morphology can include nitrogen-fixing heterocysts and/or resting cells called akinetes. Formerly called blue-green algae, cyanobacteria were traditionally treated as ALGAE.

DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.

The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.

Deoxyribonucleic acid that makes up the genetic material of bacteria.

Proteins which are involved in the phenomenon of light emission in living systems. Included are the "enzymatic" and "non-enzymatic" types of system with or without the presence of oxygen or co-factors.

The genetic complement of a plant (PLANTS) as represented in its DNA.

Submicron-sized fibers with diameters typically between 50 and 500 nanometers. The very small dimension of these fibers can generate a high surface area to volume ratio, which makes them potential candidates for various biomedical and other applications.

Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.

A species of the genus SACCHAROMYCES, family Saccharomycetaceae, order Saccharomycetales, known as "baker's" or "brewer's" yeast. The dried form is used as a dietary supplement.

Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)

Established cell cultures that have the potential to propagate indefinitely.

The unfavorable effect of environmental factors (stressors) on the physiological functions of an organism. Prolonged unresolved physiological stress can affect HOMEOSTASIS of the organism, and may lead to damaging or pathological conditions.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Procedures for enhancing and directing tissue repair and renewal processes, such as BONE REGENERATION; NERVE REGENERATION; etc. They involve surgically implanting growth conducive tracks or conduits (TISSUE SCAFFOLDING) at the damaged site to stimulate and control the location of cell repopulation. The tracks or conduits are made from synthetic and/or natural materials and may include support cells and induction factors for CELL GROWTH PROCESSES; or CELL MIGRATION.

The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.

Plant cell inclusion bodies that contain the photosynthetic pigment CHLOROPHYLL, which is associated with the membrane of THYLAKOIDS. Chloroplasts occur in cells of leaves and young stems of plants. They are also found in some forms of PHYTOPLANKTON such as HAPTOPHYTA; DINOFLAGELLATES; DIATOMS; and CRYPTOPHYTA.

Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.

Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt GENETIC TRANSLATION of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation.

The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).

Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.

The parts of a macromolecule that directly participate in its specific combination with another molecule.

Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).

The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.

Methods for maintaining or growing CELLS in vitro.

Protein analogs and derivatives of the Aequorea victoria green fluorescent protein that emit light (FLUORESCENCE) when excited with ULTRAVIOLET RAYS. They are used in REPORTER GENES in doing GENETIC TECHNIQUES. Numerous mutants have been made to emit other colors or be sensitive to pH.

The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

Family of RNA viruses that infects birds and mammals and encodes the enzyme reverse transcriptase. The family contains seven genera: DELTARETROVIRUS; LENTIVIRUS; RETROVIRUSES TYPE B, MAMMALIAN; ALPHARETROVIRUS; GAMMARETROVIRUS; RETROVIRUSES TYPE D; and SPUMAVIRUS. A key feature of retrovirus biology is the synthesis of a DNA copy of the genome which is integrated into cellular DNA. After integration it is sometimes not expressed but maintained in a latent state (PROVIRUSES).

The systematic study of the complete DNA sequences (GENOME) of organisms.

Salts and esters of the 10-carbon monocarboxylic acid-decanoic acid.

A network of cross-linked hydrophilic macromolecules used in biomedical applications.

An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.

A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.

The techniques used to produce molecules exhibiting properties that conform to the demands of the experimenter. These techniques combine methods of generating structural changes with methods of selection. They are also used to examine proposed mechanisms of evolution under in vitro selection conditions.

Any of the processes by which cytoplasmic or intercellular factors influence the differential control of gene action in bacteria.

A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Bone-marrow-derived, non-hematopoietic cells that support HEMATOPOETIC STEM CELLS. They have also been isolated from other organs and tissues such as UMBILICAL CORD BLOOD, umbilical vein subendothelium, and WHARTON JELLY. These cells are considered to be a source of multipotent stem cells because they include subpopulations of mesenchymal stem cells.

Antibodies produced by a single clone of cells.

Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.

Implants constructed of materials designed to be absorbed by the body without producing an immune response. They are usually composed of plastics and are frequently used in orthopedics and orthodontics.

One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.

The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.

Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.

A continuous protein fiber consisting primarily of FIBROINS. It is synthesized by a variety of INSECTS and ARACHNIDS.

Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum. (1/3961)

We examined the effectiveness of antisense RNA (as RNA) strategies for metabolic engineering of Clostridium acetobutylicum. Strain ATCC 824(pRD4) was developed to produce a 102-nucleotide asRNA with 87% complementarity to the butyrate kinase (BK) gene. Strain ATCC 824(pRD4) exhibited 85 to 90% lower BK and acetate kinase specific activities than the control strain. Strain ATCC 824(pRD4) also exhibited 45 to 50% lower phosphotransbutyrylase (PTB) and phosphotransacetylase specific activities than the control strain. This strain exhibited earlier induction of solventogenesis, which resulted in 50 and 35% higher final concentrations of acetone and butanol, respectively, than the concentrations in the control. Strain ATCC 824(pRD1) was developed to putatively produce a 698-nucleotide asRNA with 96% complementarity to the PTB gene. Strain ATCC 824(pRD1) exhibited 70 and 80% lower PTB and BK activities, respectively, than the control exhibited. It also exhibited 300% higher levels of a lactate dehydrogenase activity than the control exhibited. The growth yields of ATCC 824(pRD1) were 28% less than the growth yields of the control. While the levels of acids were not affected in ATCC 824(pRD1) fermentations, the acetone and butanol concentrations were 96 and 75% lower, respectively, than the concentrations in the control fermentations. The lower level of solvent production by ATCC 824(pRD1) was compensated for by approximately 100-fold higher levels of lactate production. The lack of any significant impact on butyrate formation fluxes by the lower PTB and BK levels suggests that butyrate formation fluxes are not controlled by the levels of the butyrate formation enzymes. (+info)

Enhanced bioaccumulation of heavy metal ions by bacterial cells due to surface display of short metal binding peptides. (2/3961)

Metal binding peptides of sequences Gly-His-His-Pro-His-Gly (named HP) and Gly-Cys-Gly-Cys-Pro-Cys-Gly-Cys-Gly (named CP) were genetically engineered into LamB protein and expressed in Escherichia coli. The Cd2+-to-HP and Cd2+-to-CP stoichiometries of peptides were 1:1 and 3:1, respectively. Hybrid LamB proteins were found to be properly folded in the outer membrane of E. coli. Isolated cell envelopes of E. coli bearing newly added metal binding peptides showed an up to 1.8-fold increase in Cd2+ binding capacity. The bioaccumulation of Cd2+, Cu2+, and Zn2+ by E. coli was evaluated. Surface display of CP multiplied the ability of E. coli to bind Cd2+ from growth medium fourfold. Display of HP peptide did not contribute to an increase in the accumulation of Cu2+ and Zn2+. However, Cu2+ ceased contribution of HP for Cd2+ accumulation, probably due to the strong binding of Cu2+ to HP. Thus, considering the cooperation of cell structures with inserted peptides, the relative affinities of metal binding peptide and, for example, the cell wall to metal ion should be taken into account in the rational design of peptide sequences possessing specificity for a particular metal. (+info)

Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli. (3/3961)

1,2-Propanediol (1,2-PD) is a major commodity chemical that is currently derived from propylene, a nonrenewable resource. A goal of our research is to develop fermentation routes to 1,2-PD from renewable resources. Here we report the production of enantiomerically pure R-1,2-PD from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes (E. coli gldA or Klebsiella pneumoniae dhaD). We also show that E. coli overexpressing the E. coli methylglyoxal synthase gene (mgs) produced 1,2-PD. The expression of either glycerol dehydrogenase or methylglyoxal synthase resulted in the anaerobic production of approximately 0.25 g of 1,2-PD per liter. R-1,2-PD production was further improved to 0.7 g of 1,2-PD per liter when methylglyoxal synthase and glycerol dehydrogenase (gldA) were coexpressed. In vitro studies indicated that the route to R-1,2-PD involved the reduction of methylglyoxal to R-lactaldehyde by the recombinant glycerol dehydrogenase and the reduction of R-lactaldehyde to R-1, 2-PD by a native E. coli activity. We expect that R-1,2-PD production can be significantly improved through further metabolic and bioprocess engineering. (+info)

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (4/3961)

The structures of complex polyketide natural products, such as erythromycin, are programmed by multifunctional polyketide synthases (PKSs) that contain modular arrangements of functional domains. The colinearity between the activities of modular PKS domains and structure of the polyketide product portends the generation of novel organic compounds-"unnatural" natural products-by genetic manipulation. We have engineered the erythromycin polyketide synthase genes to effect combinatorial alterations of catalytic activities in the biosynthetic pathway, generating a library of >50 macrolides that would be impractical to produce by chemical methods. The library includes examples of analogs with one, two, and three altered carbon centers of the polyketide products. The manipulation of multiple biosynthetic steps in a PKS is an important milestone toward the goal of producing large libraries of unnatural natural products for biological and pharmaceutical applications. (+info)

E-CELL: software environment for whole-cell simulation. (5/3961)

MOTIVATION: Genome sequencing projects and further systematic functional analyses of complete gene sets are producing an unprecedented mass of molecular information for a wide range of model organisms. This provides us with a detailed account of the cell with which we may begin to build models for simulating intracellular molecular processes to predict the dynamic behavior of living cells. Previous work in biochemical and genetic simulation has isolated well-characterized pathways for detailed analysis, but methods for building integrative models of the cell that incorporate gene regulation, metabolism and signaling have not been established. We, therefore, were motivated to develop a software environment for building such integrative models based on gene sets, and running simulations to conduct experiments in silico. RESULTS: E-CELL, a modeling and simulation environment for biochemical and genetic processes, has been developed. The E-CELL system allows a user to define functions of proteins, protein-protein interactions, protein-DNA interactions, regulation of gene expression and other features of cellular metabolism, as a set of reaction rules. E-CELL simulates cell behavior by numerically integrating the differential equations described implicitly in these reaction rules. The user can observe, through a computer display, dynamic changes in concentrations of proteins, protein complexes and other chemical compounds in the cell. Using this software, we constructed a model of a hypothetical cell with only 127 genes sufficient for transcription, translation, energy production and phospholipid synthesis. Most of the genes are taken from Mycoplasma genitalium, the organism having the smallest known chromosome, whose complete 580 kb genome sequence was determined at TIGR in 1995. We discuss future applications of the E-CELL system with special respect to genome engineering. AVAILABILITY: The E-CELL software is available upon request. SUPPLEMENTARY INFORMATION: The complete list of rules of the developed cell model with kinetic parameters can be obtained via our web site at: http://e-cell.org/. (+info)

Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties. (6/3961)

A system has been developed for generating chimeric yellow fever/Japanese encephalitis (YF/JE) viruses from cDNA templates encoding the structural proteins prM and E of JE virus within the backbone of a molecular clone of the YF17D strain. Chimeric viruses incorporating the proteins of two JE strains, SA14-14-2 (human vaccine strain) and JE Nakayama (JE-N [virulent mouse brain-passaged strain]), were studied in cell culture and laboratory mice. The JE envelope protein (E) retained antigenic and biological properties when expressed with its prM protein together with the YF capsid; however, viable chimeric viruses incorporating the entire JE structural region (C-prM-E) could not be obtained. YF/JE(prM-E) chimeric viruses grew efficiently in cells of vertebrate or mosquito origin compared to the parental viruses. The YF/JE SA14-14-2 virus was unable to kill young adult mice by intracerebral challenge, even at doses of 10(6) PFU. In contrast, the YF/JE-N virus was neurovirulent, but the phenotype resembled parental YF virus rather than JE-N. Ten predicted amino acid differences distinguish the JE E proteins of the two chimeric viruses, therefore implicating one or more residues as virus-specific determinants of mouse neurovirulence in this chimeric system. This study indicates the feasibility of expressing protective antigens of JE virus in the context of a live, attenuated flavivirus vaccine strain (YF17D) and also establishes a genetic system for investigating the molecular basis for neurovirulence determinants encoded within the JE E protein. (+info)

A small catalytic RNA motif with Diels-Alderase activity. (7/3961)

BACKGROUND: The 'RNA world' hypothesis requires that RNA be able to catalyze a wide variety of chemical reactions. In vitro selection from combinatorial RNA libraries has been used to identify several catalytic activities, most of which have resulted in a self-modification of RNA at one of its constituents. The formation of carbon-carbon bonds is considered an essential prerequisite for a complex metabolism based on RNA. RESULTS: We describe the selection and characterization of new ribozymes that catalyze carbon-carbon bond formation by Diels-Alder reaction of a biotinylated maleimide with an RNA-tethered anthracene. Secondary structure analysis identified a 49-nucleotide RNA motif that accelerates the reaction about 20,000-fold. The motif has only 11 conserved nucleotides that are present in most of the selected sequences. The ribozyme motif is remarkably adaptable with respect to cofactor and metal-ion requirements. The motif was also re-engineered to give a 38-mer RNA that can act as a 'true' catalyst on short external substrate oligonucleotide-anthracene conjugates. CONCLUSIONS: We have identified a small, highly abundant RNA motif that can solve the complex task of forming two carbon-carbon bonds between two reactants in trans, a catalytic capacity useful for creating prebiotically relevant molecules. This is the smallest and fastest RNA catalyst for carbon-carbon bond formation reported to date. (+info)

Heterologous expression of alkene monooxygenase from Rhodococcus rhodochrous B-276. (8/3961)

Alkene monooxygenase (AMO) from Rhodococcus rhodochrous (formerly Nocardia corallina) B-276 is a three-component enzyme system encoded by the four-gene operon amoABCD. AMO catalyses the stereoselective epoxygenation of aliphatic alkenes, yielding primarily R enantiomers. The presumed site of alkene oxygenation is a dinuclear iron centre similar to that in the soluble methane monooxygenases of methanotrophic bacteria, to which AMO exhibits a significant degree of amino acid sequence identity. The AMO complex was not expressed in Escherichia coli, at least partly because that host did not produce all of the AMO polypeptides. Expression of AMO was achieved in Streptomyces lividans by cloning the AMO genes into the thiostrepton-inducible expression plasmid pIJ6021. No background of AMO activity was detected in S. lividans cells without amoABCD and expression of AMO activity, at a level comparable to that from wild-type R. rhodochrous B-276, coincided with appearance of the AMO subunits. Recombinant AMO activity in cell-free extracts of S. lividans was stimulated by the addition of NADH and produced R-epoxypropane with comparable enantiomeric excess to AMO purified from the original organism. Although the whole AMO complex could not be expressed in E. coli, the functional coupling protein (AmoB) and reductase (AmoD) were expressed individually in E. coli as fusions with glutathione S-transferase. The expression systems described here now allow structure/function studies on AMO to be carried out by site-directed mutagenesis. (+info)

Moore, Pete (2007). The Debate About Genetic Engineering (Ethical Debates). New York, NY: Rosen Central. ISBN 978-1-4042-3754-4 ... The carrier frequency in the Ashkenazi Jewish population is about one in 90.[8] Genetic counseling and genetic testing are ... FA is the result of a genetic defect in a cluster of proteins responsible for DNA repair via homologous recombination.[1] The ... Fanconi anaemia (FA) is a rare genetic disease resulting in impaired response to DNA damage. Although it is a very rare ...

https://en.wikipedia.org/wiki/Fanconi_anemia

"Genetic Engineering". Greenpeace. "Golden Rice: All glitter, no gold". Greenpeace. March 16, 2005. Greenpeace. 2005. All that ... Golden Rice is a variety of rice (Oryza sativa) produced through genetic engineering to biosynthesize beta-carotene, a ... Critics of genetically engineered crops have raised various concerns. An early issue was that Golden Rice originally did not ... The molecular-genetic characterisation of GR2E rice, including the assessment of potential toxic or allergic reaction to the ...

https://en.wikipedia.org/wiki/Golden_rice

Aspects of genetics including mutation or hybridisation, cloning (as in Brave New World), genetic engineering, and eugenics ... Schmeink, Lars (2017). Biopunk Dystopias Genetic Engineering, Society and Science Fiction. Liverpool University Press. pp. 8-. ... Stableford, Brian (15 May 2017). "Genetic Engineering". The Encyclopedia of Science Fiction. Retrieved 19 July 2018. Zimmer, ... and genetic engineering. The ethical implications of modifying humans (and all their descendants) were brought into focus with ...

https://en.wikipedia.org/wiki/Biology_in_fiction

"What Is Genetic Engineering?". Union of Concerned Scientists. Retrieved May 18, 2015. "genetic engineering". Tech Target. ... Genetic Engineering can be considered to be the purposeful alteration of the genetic makeup of an organism through the ... However, genetic engineering embodies much of what is considered postnatural, but doing so with the next level of technology ... Genetic engineering is a contentious topic and even in searching for a definition, there are several alternatives available ...

https://en.wikipedia.org/wiki/Postnaturalism

... genetic engineering; a new human condition arising from interaction with technology. The book advances a model of education for ... He studied electrical engineering, telecommunications and computer science, as well as studying at the Polytechnic University ... Mihai Nadin (born February 2, 1938 in Braşov, Romania) is a scholar and researcher in electrical engineering, computer science ...

https://en.wikipedia.org/wiki/Mihai_Nadin

Rotherham, Fiona (1 June 2001). "The genetic engineer". ShareChat. Retrieved 23 April 2013. "John Gallagher - Director". ... In 1963, Gallagher Engineering Limited was established. A mainstay of the business was the electric fence, now revised to run ... Alfred William Gallagher MBE (17 May 1911 - 8 August 1990) was a New Zealand inventor, manufacturing engineer and businessman. ...

https://en.wikipedia.org/wiki/Bill_Gallagher_(inventor)

Flanagan, Nina (August 2005). "Bioresearch Highlights Significance of SNPs". Genetic Engineering News. Vol. 25, no. 14. Mary ... Founder populations are very valuable to medical genetic research as they are pockets of low genetic variability which provide ...

https://en.wikipedia.org/wiki/Demographics_of_Quebec

"SuperGen to Merge with Astex for $25M in Cash". Genetic Engineering News. 7 April 2011. Retrieved 14 April 2021. "SuperGen, Inc ...

https://en.wikipedia.org/wiki/Astex_Pharmaceuticals

... and Genetic engineering. Having been on the Council of the Society for General Microbiology since 1966, he became President ... 1987) The Genetic Analysis of Nitrogen Fixation, Oxygen Tolerance and Hydrogen Uptake in Azotobacters. ibid, 159-171 doi: ... the creation of mobile genetic elements carrying that cluster and the transfer therewith of the ability to fix nitrogen to ... wholly new bacteria by genetic manipulation. One of the Unit's plasmids came into worldwide use to study the genetics of ...

https://en.wikipedia.org/wiki/John_Postgate_(microbiologist)

cite news}}: ,last1= has generic name (help) "Life Technologies: A Look Back". Genetic Engineering News. April 15, 2013. ... Among more than 1,200 products for stem cell research, the company offered an engineered stem cell line (BG01v/hOG) and various ...

https://en.wikipedia.org/wiki/Invitrogen

Genetic Engineering & Biotechnology News. 29 (8): 14. Retrieved 2009-04-25. Official website Business data for PTC Therapeutics ...

https://en.wikipedia.org/wiki/PTC_Therapeutics

"Teva Invests $19M More in CureTech After Positive Phase II DLBCL Data". Genetic Engineering & Biotechnology News. September ...

https://en.wikipedia.org/wiki/Pidilizumab

Sigma Advanced Genetic Engineering (SAGE) Labs is a division within Sigma-Aldrich that specializes in genetic manipulation of ... Staff (October 15, 2014). "Merck KGaA to Acquire Sigma-Aldrich for $17B". Genetic Engineering & Biotechnology News. p. 10. " ... who hired chemical engineer Daniel Broida. 1946 - Sigma was formed from Midwest Consultants and manufactured just adenosine ...

https://en.wikipedia.org/wiki/Sigma-Aldrich

Genetic Engineering & Biotechnology News. Retrieved April 21, 2015. "Teva Offers to Buy Mylan in $40.1B Cash-And-Stock Deal". ... Genetic Engineering & Biotechnology News. Retrieved April 21, 2015. Staff (April 21, 2015). "Teva Offers to Buy Mylan for $40B ... Genetic Engineering & Biotechnology News. Retrieved April 21, 2015. Staff (April 8, 2015). "Mylan Offers $28.9B for Perrigo". ... Staff (June 3, 2014). "Teva Buys Labrys, Growing Pain Franchise in Up to $825M Deal". Genetic Engineering & Biotechnology News ...

https://en.wikipedia.org/wiki/Teva_Pharmaceuticals

"Jumping genes: from phenomenon to tool". Genetic Engineering: Plants: Environment. GMO-Safety.eu. 21 April 2006. "Transposon ... The PiggyBac (PB) transposon from the cabbage looper moth Trichoplusia ni was engineered to be highly active in mammalian cells ... Transposons as a genetic tool Transposable element Transposase Barbara McClintock "Feeding hungry mouths". Biotechnology ... A newer technique called shuttle mutagenesis uses specific cloned genes from the host species to incorporate genetic elements. ...

https://en.wikipedia.org/wiki/Transposon_mutagenesis

"Ethypharm Buying Martindale Pharma". Genetic Engineering & Biotechnology News. 2017-01-19. Retrieved 2021-09-30. "PAI to buy ...

https://en.wikipedia.org/wiki/PAI_Partners

"Tissue Regeneration Promoted through Gene Suppression". Genetic Engineering & Biotechnology News. March 2016. Kato H, Tjernberg ...

https://en.wikipedia.org/wiki/ARID1A

Genetic Analysis: Biomolecular Engineering. 15 (3-5): 167-173. doi:10.1016/s1050-3862(99)00022-4. PMID 10596758. (Articles ... In the rare cases that they do integrate this new genetic information, the pattern of expression of the injected transgene's ... In mice, there is an additional option for genetic transfer that is not available in other animals. Embryonic stem cells ... They also allow precise genetic modifications by gene targeting. Modified embryonic stem cells can be selected in vitro before ...

https://en.wikipedia.org/wiki/Polly_and_Molly

Staff (2009). "Clinical Trials Update". Genetic Engineering & Biotechnology News. 29 (8): 58. v t e (All stub articles, ...

https://en.wikipedia.org/wiki/Vascular-targeting_agent

Carroll, Sean B. (June 8, 2007). "God as Genetic Engineer". Science Magazine. 316 (5830): 1427-1428. doi:10.1126/science. ... God as Genetic Engineer. A review of Michael Behe's book "The Edge of Evolution: The Search for the Limits of Darwinism" (2007 ... Carroll, Sean B. (2008). "Evo-Devo and an Expanding Evolutionary Synthesis: A Genetic Theory of Morphological Evolution". Cell ... "Genetic control of body pattern in fruit flies, butterflies, and other animals". Carroll's team has shown, in a series of ...

https://en.wikipedia.org/wiki/Sean_B._Carroll

... basic principles and prospects for genetic engineering". Biotechnology & Genetic Engineering Reviews. 2: 341-363. doi:10.1080/ ... Specific delta-endotoxins that have been inserted with genetic engineering include Cry3Bb1 found in MON 863 and Cry1Ab found in ...

https://en.wikipedia.org/wiki/Delta_endotoxin

"Products & Services Deals". Genetic Engineering & Biotechnology News. 34 (1): 11-11. January 2014. doi:10.1089/gen.34.01.08. ...

https://en.wikipedia.org/wiki/DNASTAR

"GEN Congressional Hall of Fame". Genetic Engineering & Biotechnology News. February 6, 2013. Retrieved September 24, 2013. " ... The Genetic Information Nondiscrimination Act is designed to prohibit discrimination by employers or health insurers based upon ... During her entire tenure, she was a "fierce advocate" for medical research, women's health, neurology and genetic rights. In ... Slaughter was the lead House sponsor of the Genetic Information Nondiscrimination Act, which became law in 2008. Along with ...

https://en.wikipedia.org/wiki/Louise_Slaughter

Ladner RC (2007-01-01). "Mapping the epitopes of antibodies". Biotechnology & Genetic Engineering Reviews. 24 (1): 1-30. ... This technique involves altering the genetic information of cells. Many improvements to this method lie in the improvement of ...

https://en.wikipedia.org/wiki/Immunofluorescence

Reproductive and Genetic Engineering. 2 (1): 39-49. Archived from the original (PDF) on 4 December 2014. Retrieved 3 September ... plant-reprogramming insects: from effector molecules to ecosystem engineering. 84: 90-102. doi:10.1016/j.jinsphys.2015.07.011. ...

https://en.wikipedia.org/wiki/Pseudomonas_syringae

Philipiddis, Alex (15 June 2014). "Incubators Blossom along with Their Startups". Genetic Engineering & Biotechnology News. Vol ... Genetic Engineering & Biotechnology News, Mary Ann Liebert, Inc., vol. 29, no. 9, pp. 1, 18-19, ISSN 1935-472X, OCLC 77706455, ... National Institute for Biotechnology and Genetic Engineering, Faisalabad Arfa Karim Technology Park (former Software Technology ... NE Rensselaer Technology Park at RPI Metrotech Center at New York University Tandon School of Engineering Research Triangle ...

https://en.wikipedia.org/wiki/List_of_research_parks

Genetic Analysis: Biomolecular Engineering. 12 (2): 81-4. doi:10.1016/1050-3862(95)00122-0. PMID 8574898. Gibson, Greg. Muse, ...

https://en.wikipedia.org/wiki/Fosmid

Genetic Engineering & Biotechnology News. Retrieved 2018-04-15. "Annual Report 2016" (PDF). Investor Relations. Lonza. ... Retrieved 2018-04-15.[self-published source] "Lonza Buys Capsugel for $5.5B Cash". Genetic Engineering & Biotechnology News. 15 ...

https://en.wikipedia.org/wiki/Lonza_Group

"Sweet potato is a natural GMO". Genetic Engineering & Biotechnology News. 22 April 2015. Retrieved 23 April 2015. Doucleff, ... Genetic similarities have been found between Polynesian peoples and indigenous Americans including the Zenú, a people ... This theory is also supported by genetic evidence. In Australia, about 90% of production is devoted to the orange cultivar ' ... Zhang, D.P.; Ghislain, M.; Huaman, Z.; Cervantes, J.C.; Carey, E.E. (1999). "AFLP Assessment of Sweetpotato Genetic Diversity ...

https://en.wikipedia.org/wiki/Sweet_potato

Staff (15 February 2015). "Abcam Buys Firefly for $28M to Broaden Multiplex Analysis Capabilities". Genetic Engineering & ... Genetic Engineering & Biology News. 24 May 2011. Retrieved 21 December 2015. "Abcam H1 2018 Interim Report" (PDF). www.abcamplc ...

https://en.wikipedia.org/wiki/Abcam

"A Genetic 'Chain Saw' to Target Harmful DNA". Wall Street Journal. Archived from the original on March 6, 2018. Retrieved ... delivered by engineered bacteriophages. The intended therapeutic targets are antibiotic-resistant bacterial infections. The ... Brown, Kristen V. (February 24, 2017). "Scientists Are Creating a Genetic Chainsaw to Hack Superbug DNA to Bits". Gizmodo. G/O ... Wiedenheft B, Sternberg SH, Doudna JA (February 2012). "RNA-guided genetic silencing systems in bacteria and archaea". Nature. ...

https://en.wikipedia.org/wiki/Locus_Biosciences

Many genetic sequences are expressed in a bacteriophage library in the form of fusions with the bacteriophage coat protein, so ... "CAR T Cells: Engineering Patients' Immune Cells to Treat Their Cancers". National Cancer Institute. 2013-12-06. Retrieved 9 ... The protein displayed corresponds to the genetic sequence within the phage. This phage-display library is added to the dish and ... Phage display is also a widely used method for in vitro protein evolution (also called protein engineering). As such, phage ...

https://en.wikipedia.org/wiki/Phage_display

Wright and Meyerdirk left the university to form Physionic Engineering Inc., which launched the first commercial hand-held ... the ISUOG recommends that pregnant patients who desire genetic testing have obstetric ultrasounds between 11 weeks' and 13 ...

https://en.wikipedia.org/wiki/Obstetric_ultrasonography

In electrical engineering, statistical computing and bioinformatics, the Baum-Welch algorithm is a special case of the ... and in particular genetic information. They have since become an important tool in the probabilistic modeling of genomic ... This can involve reverse engineering a channel encoder. HMMs and as a consequence the Baum-Welch algorithm have also been used ...

https://en.wikipedia.org/wiki/Baum–Welch_algorithm

Felix, Rocel C. (7 April 2006). "Genetic Engineering Eyed to Solve Problems of Abaca Industry". NewsFlash.org. STAR. Archived ...

https://en.wikipedia.org/wiki/Southern_Leyte

Sukachev, V. N. (1944). О принципах генетической классификации в биоценологии [On the principles of genetic classification in ... engineer, geographer, and corresponding member (1920) and full member (1943) of the USSR Academy of Sciences. His wife was ... Soviet engineers, 1880 births, 1967 deaths, Dendrologists, Forestry academics, Forestry in Russia, History of forestry ...

https://en.wikipedia.org/wiki/Vladimir_Sukachev

The most recent law to be passed is Title II of the Genetic Information Nondiscrimination Act of 2008. In essence, this law ... Industrial Engineer. 42 (8): 34-39. Gale A234582537. Paulhus, Delroy L. (1998). "Interpersonal and intrapsychic adaptiveness of ... or genetic information (note: additional classes may be protected depending on state or local law). More specifically, an ... prohibits the discrimination of employees or applicants due to an individual's genetic information and family medical history ...

https://en.wikipedia.org/wiki/Job_interview

Lister also realises that the in-vitro tube with Kochanski and Lister's genetic information is Lister himself, creating a ... Grogan returns in this episode, portraying an illusion of Kochanski created by the genetically engineered lifeforms the Psirens ...

https://en.wikipedia.org/wiki/Kristine_Kochanski

Through genetic engineering, Calgene hoped to slow down the ripening process of the tomato and thus prevent it from softening ... Genetic engineering in the United States, Monsanto, 1992 in biotechnology, Tomatoes). ... The harmful, parasitic genetic material was removed from the bacterial T-plasmid and was replaced by the favored genes. The ... Because some members of the public were misinformed on genetic technology, people feared the Flavr Savr and other genetically ...

https://en.wikipedia.org/wiki/Flavr_Savr

The explanation was that the simo-leap with Al had left Sam with enough of Al's genetic coding that he could leap back past his ... Fictional engineers, Fictional farmers, Fictional linguists, Fictional Nobel laureates, Fictional physicians, Fictional ... In the fifth-season episode "Trilogy (Part 2)," Sam fathers a child who proves to be his true genetic child, not the child of ... the explanation was that Sam's close genetic link with his ancestor allowed him to do this. This was also partly due to an " ...

https://en.wikipedia.org/wiki/Sam_Beckett

Cheyer was also a member of the founding team at Change.org and a founder of Sentient Technologies (formerly Genetic Finance). ... and formerly a director of engineering in the iPhone group at Apple. Cheyer attended Sharon High School, in Sharon, ...

https://en.wikipedia.org/wiki/Adam_Cheyer

October 2003). "Metabolic engineering for microbial production of shikimic acid". Metabolic Engineering. 5 (4): 277-83. doi: ... These genetic modifications usually aim to reduce the amount of energy used to produce the product, increase yields and reduce ... Koffas M, Roberge C, Lee K, Stephanopoulos G (1999). "Metabolic engineering". Annual Review of Biomedical Engineering. 1: 535- ... Thykaer J, Nielsen J (January 2003). "Metabolic engineering of beta-lactam production". Metabolic Engineering. 5 (1): 56-69. ...

https://en.wikipedia.org/wiki/Metabolism

Bergmann, along with her team (collectively known as "The Bergmann Lab"), use a large variety of genetic, genomic and imaging ... Also in 2010, Bergmann was an Obama-era recipient of the Presidential Early Career Award for Scientists and Engineers. and ...

https://en.wikipedia.org/wiki/Dominique_Bergmann

However, virus-encoded genetic elements have the ability to antagonize the IFN response contributing to viral pathogenesis and ... Annual Review of Chemical and Biomolecular Engineering. 2: 77-96. doi:10.1146/annurev-chembioeng-061010-114133. PMID 22432611. ... "Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance". Nature. 461 (7262): 399-401. Bibcode: ...

https://en.wikipedia.org/wiki/Interferon

... but these studies had a solely genetic basis rather than a microscopy based approach. In the year 2000, a study by Simpson et ... Annals of Biomedical Engineering. 37 (10): 2064-2081. doi:10.1007/s10439-009-9723-0. ISSN 1573-9686. PMC 2855900. PMID 19495981 ...

https://en.wikipedia.org/wiki/Bacillus_virus_phi29

The Boom In Genetic Engineering: Genentech's Herbert Boyer". Time. February 9, 2002. Cover. Retrieved May 7, 2019. Itakura, K; ... thereby jump-starting the field of genetic engineering. By 1969, he performed studies on a couple of restriction enzymes of the ...

https://en.wikipedia.org/wiki/Herbert_Boyer

Engineering and Medicine, International Agency for Research on Cancer (IARC) and American Association for Cancer Research (AACR ... and genetic testing." (Mentors: John D. Potter, Stephen Schwartz) 1991/92: Fulbright Scholarship and Fulbright Professional ... "Association of aspirin and non-steroidal anti-inflammatory drug use with risk of colorectal cancer according to genetic ...

https://en.wikipedia.org/wiki/Cornelia_Ulrich

Genetic Engineering and Biotechnology News. Mary Ann Liebert. Retrieved 6 Nov 2019. Baker, Liana; Roumeliotis, Greg (19 May ... "Stanford Engineering, Abbas El Gamal - Previous Students". Stanford University. Stanford University. 2019. Retrieved 5 Nov 2019 ... Dan V. Nicolau; Ramesh Raghavachari; Society of Photo-optical Instrumentation Engineers (2003). "Modeling and simulation of ... EP 3087204, Eltoukhy, Helmy & Talasaz, AmirAli, "Methods and systems for detecting genetic variants", published 2015-07-15, ...

https://en.wikipedia.org/wiki/Helmy_Eltoukhy

An increase in copy number is useful for genetic engineering applications to increase the production yield of recombinant ... which makes it suitable as a genetic engineering tool. It is capable of transfer, replication, and maintenance in most genera ... C M Thomas, and C A Smith: "Incompatibility Group P Plasmids: Genetics, Evolution, and Use in Genetic Manipulation", Annual ... as there are less superfluous genetic elements which might affect the processes being studied. Several mutants of PFF1 which ...

https://en.wikipedia.org/wiki/RK2_plasmid

Ganathan engineers repair the Falcon and equip it with a lightning cannon while the team meets Ganath's ruler, Empatojayos ... The physician had deliberately inserted genetic material and contaminants into all stored samples of the Emperor's original ... unless he can either fix his genetic material (an impossibility since no unaltered samples remain) or insert his spirit into ...

https://en.wikipedia.org/wiki/Dark_Empire

A number of genetic components of aging have been identified using model organisms, ranging from the simple budding yeast ... senescence Programmed cell death Regenerative medicine Rejuvenation SAGE KE Stem cell theory of aging Strategies for engineered ... Therefore, a genetic load of late-acting deleterious mutations could be substantial at mutation-selection balance. This concept ... If a genetic disaster... happens late enough in individual life, its consequences may be completely unimportant". Age- ...

https://en.wikipedia.org/wiki/Senescence

Genetic engineering of the paddle region from a species of volcano-dwelling archaebacteria into rat brain potassium channels ...

https://en.wikipedia.org/wiki/Voltage-gated_ion_channel

... opposes the planned use of golden rice, a variety of Oryza sativa rice produced through genetic engineering to ... Patents on Rice: the Genetic Engineering Hypocrisy Archived 3 December 2008 at the Wayback Machine. 26 April 2005. "Prof. Dr. ... genetic engineering, and anti-nuclear issues. It uses direct action, lobbying, research, and ecotage to achieve its goals. The ... "Diversity in the genetic resources of oil palm", Achieving sustainable cultivation of oil palm Volume 1, Burleigh Dodds Science ...

https://en.wikipedia.org/wiki/Greenpeace

December 2020). "Automated design of thousands of nonrepetitive parts for engineering stable genetic systems". Nature ... Some cases of many genetic diseases are associated with variations in promoters or transcription factors. Examples include: ... Wikimedia Commons has media related to Genetic promoter regions. ORegAnno - Open Regulatory Annotation Database Identifying a ... Promoters are important gene regulatory elements used in tuning synthetically designed genetic circuits and metabolic networks ...

https://en.wikipedia.org/wiki/Promoter_(genetics)

"National Academy of Engineering Elects 86 Members and 18 Foreign Members". NAE Website. "Kiran Mazumdar Shaw inducted into NAE ... Yeast expression platforms offer a desirable alternative to mammalian cell cultures for the genetic manipulation of cells for ... She was elected as a member of the United States National Academy of Engineering (NAE) in 2019 for the development of ... Kiran Mazumdar Shaw inaugurating MBA Program". Amruta Institute of Engineering and Management Sciences. Retrieved 24 September ...

https://en.wikipedia.org/wiki/Kiran_Mazumdar-Shaw

Genetic data has also supported this stratification. In three genetic studies representing the whole of South Asian Muslims, it ... Asghar Ali Engineer, Islam in India: The Impact of Civilizations. Shipra Publications, 2002. ISBN 81-7541-115-5. Mohamed Taher ... In two of the three genetic studies referenced here, in which is described that samples were taken from several regions of ... In this study 124 Sunnis and 154 Shias of Uttar Pradesh were randomly selected for their genetic evaluation. Other than Muslims ...

https://en.wikipedia.org/wiki/Islam_in_India

... "moral objection for using genetic engineering to limit this particular trend". While he did not advocate abortion, he did ... Jakobovits aroused considerable controversy when, after the discovery of a possible genetic explanation for homosexuality, he ... if there were genetic explanations for homosexuality, "the errant gene" should be "removed or repaired" to prevent the " ...

https://en.wikipedia.org/wiki/Immanuel_Jakobovits,_Baron_Jakobovits

Melissa Duvall - Genetic Engineer A year prior to the story, Melissa escaped from Elysium, where her scientific skills had been ...

https://en.wikipedia.org/wiki/Twilight_X

Baker, C. S.; Cipriano, F.; Palumbi, S. R. (1996). "Molecular genetic identification of whale and dolphin products from ... "Whales as marine ecosystem engineers". Frontiers in Ecology and the Environment. 12 (7): 377-385. doi:10.1890/130220. Archived ...

https://en.wikipedia.org/wiki/Marine_mammal

Among the most notable applications of such genetic engineering is the creation of disease or insect resistant plants, such as ... Modern food and biological process engineering relies heavily on applications of genetic manipulation. By understanding plants ... "Insect-resistant Crops Through Genetic Engineering". www.aces.uiuc.edu. Retrieved 2018-04-03. "Foodborne and Waterborne Disease ... Another biological engineering process within food engineering involves the processing of agricultural waste. Though it may ...

https://en.wikipedia.org/wiki/Food_and_biological_process_engineering

... and centralized facilities necessary to carry out complex genetic engineering and to create genetically modified mice. ... Other service offerings include genetic engineering consultation, training, custom genetic engineering projects, and provision ... The mission of the Genetic Engineering Technologies (GET) group is to provide The Jackson Laboratorys faculty a one stop shop ... We are fully competent taking a project from concept to delivery of live mice and performing genetic engineering in our ...

https://www.jax.org/research-and-faculty/resources/scientific-research-services/get-and-reproductive-sci-and-tgs/genetic-engineering-technologies

https://www.genengnews.com/category/magazine/november-15-2018-vol-38-no-20/supplement-november-15-2018-vol-38-no-20/

JavaScript is disabled for your browser. Some features of this site may not work without it ...

https://extranet.who.int/iris/restricted/handle/10665/78093/browse?authority=Genetic+Engineering&type=mesh

So biologists are finding ways to identify individual genetic information and insert it into a cell, where it begins to ... The technique of recombinant DNA engineering has even caused the barriers between dissimilar species to be broken down. Scores ... For instance, if genetically engineered traits such as herbicide resistance find their way into weeds, the altered life forms ... the complete genetic blueprint found in every cell of living beings. ...

https://www.csmonitor.com/1993/0609/09142.html

Do we have the right to control the genetic complement of the human population and other eugenic considerations? ... The development of new genes combinations increases genetic diversity, which is normally considered a positive effect, but may ... Genetic Engineering: Legal and Ethical Considerations. Legal and Ethical Considerations. Genetic Engineering. *Introduction ...

https://www.infoplease.com/math-science/biology/genetics-evolution/genetic-engineering-legal-and-ethical-considerations

EFSA gives the impression that new methods of genetic engineering do not pose any new challenges for risk assessment simply ... genetic engineering, such as the gene gun. All these effects caused by the multistep process of genome editing have to be ... is holding a public consultation on plants developed with new methods of genetic engineering (genome editing). The EFSA draft ... www.testbiotech.org/en/news/efsa-holding-public-consultation-new-methods-genetic-engineering ...

https://gmwatch.org/en/106-news/latest-news/19397

There

https://www.nationalreview.com/2012/11/opposition-genetic-engineering-moral-henry-i-miller-drew-l-kershen/

At this point, we are neither prepared to condemn altogether nor to approve of genetic engineering. But we are prepared to urge ... We can point to the benefits of genetic engineering. We can also point to wrongdoing within the scientific community when one ... If you carried hemophilia in your genes and the genetic engineers could deliver your child from this affliction, would you ... Genetic engineering seems to pit the skills of scientists against the Creator God. It also seems to pit the power of a small ...

https://www.christianitytoday.com/ct/1981/may-8/editorials.html

https://www.genengnews.com/category/topics/drug-discovery/antibodies/?filter_by=random_posts

Home » Uncategorized » Transgenic Genetic Engineering. Transgenic Genetic Engineering. April 7, 2017. September 4, 2008. by ... of genetic engineering which will likely ultimately lead to transgenic people. ... Possible future: genetically engineered for endurance of an Alaskan sled dog, cheetah like speed, gorilla strength, ... and Lead the Way to Similar Models for Other Genetic Diseases ...

https://www.nextbigfuture.com/2008/09/transgenic-genetic-engineering.html

The Pros And Cons Of Genetic Engineering. 779 Words , 4 Pages. Is Genetic engineering Safe? Genetic engineering is the ... and that idea is the genetic ¬engineering of humans. The problems of human genetic engineering are what make this topic of ... Why Is Genetic Engineering Morally Wrong. 666 Words , 3 Pages. In the 21st century, many people would say that the world is on ... Pro Genetic Engineering Argumentative Essay. 456 Words , 2 Pages. Science has enabled us to thrive in a world where change is a ...

https://www.ipl.org/essay/Should-Genetic-Engineering-Be-Allowed-In-Embryo-PKN5HEN8TT

Genetic engineering from your garage. 01/04/2018. January 4, 2018. Biohackers conduct research far away from the establishment ... De la Barrera believes that investing in genetic engineering offers great opportunities for people. The biohacking scene brings ... DIY biologist Josiah Zayner even went so far as to modify and re-inject his own genetic material. Zayner sees this - even if it ... That makes Germany different than the US, where its possible for anyone to buy a starter kit for genetic experiments on ...

https://www.dw.com/en/biohacking-genetic-engineering-from-your-garage/a-42030559

Despite its potential power to improve crop yields and nutrition, genetic modification has remained controversial and is banned ... Genetic Engineering in Agriculture 2021-2031: IDTechEx. HomeResearch ReportsGenetic Engineering in Agriculture 2021-2031 ... mean that genetic engineering in agriculture is currently at a pivotal point. Genetic Engineering in Agriculture 2021-2031 ... A comparison of genetic engineering techniques. Source: Genetic Technologies in Agriculture 2020-2030 ...

https://www.idtechex.com/en/research-report/crop-biotechnology-2020-2030/750

... Dienstag, 4. Februar 2014. Schon wieder soll gentechnisch manipulierter Mais auf unseren ...

http://www.buergerwelle.de:8080/helma/twoday/sharenews/topics/Genetic+Engineering+-+Genmanipulation/

By using these tools such as Triple CRISPR or Tol2 transgenesis, we are producing various useful genetic engineered mice within ... RIKEN Center for Biosystems Dynamics Research Laboratory for Mouse Genetic Engineering. Team Leader: Kenta Sumiyama (Ph.D.) ... We are developing new techniques in mice genetic engineering including direct genome editing on fertilized eggs of mice and ...

https://www.riken.jp/en/research/labs/bdr/mouse_genet_eng/index.html

Tag Archives: genetic engineering. We are natural, we are engineered jgalder March 17, 2018. March 17, 2018. No Comments on We ... Week 9 agriculture, climate change, environment, farming, food, Food Inc., GE food, GE seeds, genetic engineering, global food ... Week 10, Week 9 biology, community, conformity, genetic engineering, ideas, individualization, intervention, natural, seeds ... I dont think that genetic engineering is wrong on principle. However, I think it is too soon to know the effects on our health ...

https://courses.washington.edu/ps385w18/tag/genetic-engineering/

Genetic engineering/External Links ‎ (← links). *Genetic engineering/Related Articles ‎ (← links). *Archive:Monthly Write-a- ...

https://en.citizendium.org/wiki/index.php?title=Special:WhatLinksHere&target=Genetic+engineering

Genetic engineering is the direct manipulation of genetic material in order to... ... There are many benefits of genetic engineering, but there are many risks too. ... There are many benefits of genetic engineering, but there are many risks too. Genetic engineering is the direct manipulation of ... The effects that genetic engineering has on the environment, living organisms and the product being engineered have been widely ...

https://www.educationindex.com/essay/Pros-and-Cons-of-Genetic-Engineering-F3CQVRH4EZ

Members of the UCONN Genetic Engineering Team join the show. They discuss attending the International Genetically Engineered ...

https://whus.org/2014/12/dna-today-genetic-engineering-team-uconn/

In recent years, breakthroughs in nanotechnology for genetic engineering have provided more favorable tools for the genetic ... A review summarizes the types of gene carriers used in plant genetic transformation, the ways of combining with foreign genes, ... The development of plant genetic engineering lags behind the development of animal genetic engineering. Plant cells differ from ... Genetic engineering began in 1973, when biochemists Herbert Boyer and Stanley Cohen developed genetic engineering by inserting ...

https://www.nanowerk.com/spotlight/spotid=59501.php

Home , Genetic Engineering: Toward The Super Human? Genetic Engineering: Toward The Super Human?. from the November 22, 2011 ... Genetic massaging has become widespread. Students at the University of Washington won a genetic engineering contest in early ... Another UW project genetically engineered bacteria to help people digest gluten. Genetic engineering has offered a wide array ... UW Team Wins Genetic-Engineering Contest - The Seattle Times. The Mouse That Shook The World - The Independent. Super Mouse ...

https://www.khouse.org/enews_article/2011/1863/print/

Here we report a method for targeted genetic engineering in primary human B cells, utilizing electroporation … ... Genome editing in human cells with targeted nucleases now enables diverse experimental and therapeutic genome engineering ... Genetic engineering in primary human B cells with CRISPR-Cas9 ribonucleoproteins J Immunol Methods. 2018 Jun;457:33-40. doi: ... Here we report a method for targeted genetic engineering in primary human B cells, utilizing electroporation of CRISPR-Cas9 ...

https://pubmed.ncbi.nlm.nih.gov/29614266/

Read More: What Klaus Schwab, WEF and WHO Reveal About Genetic Engineering ... do they have the ability to modify human behaviour through genetic re-engineering? ... Klaus Schwabs Genetic Modification. The clip below is an excerpt from a 16-minute interview by Charlie Rose on 13 November ... It changes you, if you take a genetic editing, just as an example. Its you who are changing. And of course, this has a big ...

https://davidicke.com/2022/06/07/what-klaus-schwab-wef-and-who-reveal-about-genetic-engineering/

... revolutionizes the creation of genetic material, enabling drastically accelerated development of key microbial factories for ... DNA assembly technology significantly changes things by enabling genetic engineers to reuse genetic materials. It provides a ... Tags: AgricultureBiologyBiotechnologyFood and BeverageGenetic EngineeringIndustry NewsMicrobesProduct Resource: Industry News ... Microbial Manufacturing: Genetic Engineering Breakthrough for Urban Farming. New research of MITs Research Enterprise in ...

https://www.labmanager.com/news/microbial-manufacturing-genetic-engineering-breakthrough-for-urban-farming-1387

Genetic Algorithms and Simulation for After-sales Supply Chain Re-engineering Process A.G. Bruzzone, P. Giribone, and R. ... in this paper the authors present an innovative approach based on Genetic Algorithms applied to the Shipment Network ...

https://www.actapress.com/Abstract.aspx?paperId=27189

One real difference between genetic engineering and good old sexual reproduction, Heinemann suggested, is that genetic ... Last week, I asked how different genetic engineering was from conventional breeding. My answer (to boil some 2,000 words down ... When I asked Anastasia Bodnar of Biofortified (which generally favors genetic engineering) about this, she said that these ... Normal (non-engineered) rice, for instance, has lots of it; moreover, it has thousands of RNA sequences that match (and ...

https://grist.org/food/genetic-engineering-do-the-differences-make-a-difference/republish/

... genetic engineering and related disciplines gained fame through capacities granted by gene therapy. It appears that it should ... Recently, genetic engineering and related disciplines gained fame through capacities granted by gene therapy. It appears that ... Question: If we had the ability to perfectly genetically engineer ourselves, with no chance of failure:. *What would you change ... Lots of genes have their effect during early development; just because some trait is partly genetic doesnt mean you can affect ...

https://www.lesswrong.com/posts/HkuAWJndzryzPvgXH/genetic-engineering-how-would-you-change-your-dna

Genetic engineering in research: same same, but different. In order to better understand the recycling of receptors in the cell ... "So the cells have enough time to adapt and find ways to compensate for the consequences of this genetic manipulation.". Method ...

https://www.biozentrum.unibas.ch/news/detail/genetic-engineering-in-research-same-same-but-different

MITs Department of Mechanical Engineering (MechE) offers a world-class education that combines thorough analysis with hands-on ... Quantum Physics Meets Genetic Engineering. Researchers use engineered viruses to provide quantum-based enhancement of energy ... By engineering a virus that Belcher has worked with for years, the team was able to get it to bond with multiple synthetic ... So far, the engineered viruses collect and transport energy from incoming light, but do not yet harness it to produce power (as ...

https://meche.mit.edu/news-media/quantum-physics-meets-genetic-engineering

THE ETHICS OF USING GENETIC ENGINEERING FOR SEX SELECTION. As far as I know, no one has tried to use genetic engineering for ... Germline engineering targets the genes in eggs, sperm, or very early embryos. A way of using genetic engineering for sex ... The human genome project-launch pad for human genetic engineering. In: Stock G, Campbell J, eds. Engineering the human germline ... There are two kinds of genetic engineering: somatic and germline. Somatic engineering targets the genes in specific organs and ...

https://jme.bmj.com/content/31/2/116.full

Scores of companies are field-testing biotech products with novel genetic combinations: cantaloupe and yellow squash containing bacteria and virus genes, corn with firefly genes, and rice with pea genes. (csmonitor.com)
EFSA gives the impression that new methods of genetic engineering do not pose any new challenges for risk assessment simply because no additional genes are inserted. (gmwatch.org)
If you carried hemophilia in your genes and the genetic engineers could deliver your child from this affliction, would you reject their science? (christianitytoday.com)
They're interested in genes and genetic information and want to know how to make their own laboratory equipment without spending lots of money. (dw.com)
Together with a friend who's familiar with electrical engineering, he's also working on a device that automatically reproduces genes. (dw.com)
Based on the characteristics of nanomaterials, a new review article ( 'Nanotechnology Strategies for Plant Genetic Engineering' ) by scientists at the School of Food and Biological Engineering at the Hefei University of Technology, summarizes the types of gene carriers used in plant genetic transformation, the ways of combining with foreign genes, and the differences and advantages compared with earlier traditional transgenic methods. (nanowerk.com)
Research groups led by Botond Roska at the Friedrich Miescher Institute for Biomedical Research (FMI) and Daniel Müller at the ETH Zurich Department of Biosystems Science and Engineering (D BSSE) have developed a novel method that allows them to efficiently deliver genes into single cells in whole tissues. (phys.org)
With the help of genetic engineering it is possible to directly manipulate an organism's genes using biotechnology. (advancemarketanalytics.com)
Through genetic engineering, for example, researchers could insert genes, from a similar or unrelated species, that help a tree tolerate or fight an insect or fungus. (ien.com)
Genetics is the study of genes , heredity , and the variation of organisms , as well as the medical practice of diagnosing, treating, and counseling patients with genetic disorders . (wikipedia.org)
Genetically engineered (GE) foods have had their DNA changed using genes from other plants or animals. (medlineplus.gov)
Genetic engineering allows scientists to move desired genes from one plant or animal into another. (medlineplus.gov)
Recently, I discovered that certain "jumping genes"- mobile genetic elements found in all domains of life, including bacteria and humans-employ variant CRISPR systems to move themselves from one chromosomal site to another, without making DNA breaks. (pewtrusts.org)

The European Food Safety Authority (EFSA) is holding a public consultation on plants developed with new methods of genetic engineering (genome editing). (gmwatch.org)
The report provides in-depth technical and market insight into the different genetic technologies used in crop agriculture, including transgenics (GMOs), genome editing techniques (CRISPR, TALENs, ZFNs, etc.) and breeding strategies, while also exploring the regulatory and industrial landscapes in which they operate. (idtechex.com)
We are developing new techniques in mice genetic engineering including direct genome editing on fertilized eggs of mice and microdevice-based easy and precise aggregation method to obtain complete ES cell derived chimeric mice. (riken.jp)
The term genetic engineering describes a process in which a type of genetic modification is made to an organism's genome that involves an intended targeted change in a plant or animal gene sequence to effect a specific result through the use of DNA and, more recently, RNA technology. (nanowerk.com)
Plant genetic engineering can be categorized into three main groups: traditional plant transformation, nanomaterial-mediated gene-delivery system, and genome editing. (nanowerk.com)
Genome editing in human cells with targeted nucleases now enables diverse experimental and therapeutic genome engineering applications, but extension to primary human B cells remains limited. (nih.gov)
just because some trait is partly genetic doesn't mean you can affect it by altering the adult genome. (lesswrong.com)
The development of zinc finger nuclease (ZFN) technology has enabled the genetic engineering of the rat genome. (aspetjournals.org)
Using the ever-expanding genome engineering toolbox to facilitate drug discovery. (gene.com)
I came to Genentech in 2006 after completing a postdoctoral fellowship in mouse cancer genetics and genome engineering in the joint laboratory of Drs. Neal Copeland and Nancy Jenkins at the National Cancer Institute, Frederick, Maryland. (gene.com)
Specifically, a postdoc in my laboratory can take advantage of in-house expertise in mouse genome engineering, animal model generation and advanced cell line engineering and apply this to facilitate scientific and drug discovery. (gene.com)
In addition he/she can explore the power of genetics in model systems using innovative combinations of genetic tools and latest genome engineering technology. (gene.com)
My lab uses and develops state-of-the-art genome engineering tools to facilitate the design and generation of animal models for basic research purposes and to facilitate and accelerate drug discovery. (gene.com)
New genome engineering tools such as nucleases allow us to not only develop these models faster than before, but also enable us to make more sophisticated models. (gene.com)
Genome-wide approaches to epidermal function include short interfering RNA-based genetic screens in cultured human epidermal cells 8 and RNA interference-mediated gene knockdown via in utero microinjection of lentiviral vectors 9 . (nature.com)

Plant genetic engineering can rapidly and directionally improve the target traits of crops, break the bottleneck of conventional breeding, and achieve simultaneous improvement of crop quality and yield to meet human needs. (nanowerk.com)
Genetic engineering has many and varied effects on biodiversity, but its likely long-term result will be a decrease in genetic variability of crops and other species. (landinstitute.org)
Although genetic engineering (GE) proponents claim GE crops will cut pesticide use, this is not necessarily true. (organicitsworthit.org)
Genetically engineered (GE) crops do not necessarily reduce pesticide use, according to a World Wildlife Fund Canada report. (organicitsworthit.org)
Do Genetically Engineered Crops Reduce Pesticide Use? (organicitsworthit.org)
A report, "Impacts of Genetically Engineered Crops on Pesticide Use in the United States: The First Eight Years," prepared by Charles M. Benbrook shows the planting of GE crops in the United States since 1996 increased pesticide use by about 50 million pounds. (organicitsworthit.org)
Impacts of Genetically Engineered Crops on Pesticide Use in the United States: The First Eight Years," November 2003. (organicitsworthit.org)
Committee on genetically engineered crops: past experience and future prospects. (medlineplus.gov)
genetically engineered crops: experiences and prospects. (medlineplus.gov)
In the first half, author and consumer activist Jeffrey Smith discussed the breaking news surrounding the debate around GMO (genetically engineered) crops and foods and their potential health hazards. (coasttocoastam.com)
In quick secession the USDA approved three different genetically engineered crops, as we reported to you last month. (anh-usa.org)

Another UW project genetically engineered bacteria to help people digest gluten. (khouse.org)
Studying bacteria has lead to the relatively new science of genetic engineering. (dnatube.com)
Genetic engineering can be done with plants, animals, or bacteria and other very small organisms. (medlineplus.gov)
When a virus infects bacteria, it injects DNA or RNA into the cell, which responds by releasing a form of nuclease (Cas9) to take a snippet of the DNA or RNA sequence and store something equivalent to a genetic memory of the infection. (zmescience.com)

For instance, if genetically engineered traits such as herbicide resistance find their way into weeds, the altered life forms could disrupt natural ecosystems. (csmonitor.com)
Danielle Simmons,Ph.D states , "Of course, as genetic research advances, tests are continually being developed for traits and behaviors that are not related to disease. (ipl.org)
Genetic engineering is the direct manipulation of genetic material in order to alter the hereditary traits of a cell, organism, or population. (educationindex.com)
Genetic engineering also helps speed up the process of creating new foods with desired traits. (medlineplus.gov)
Instead of simply breeding semi-blindly and hoping that we get a good result from animals that display positive genetic traits that we wish to emphasize, we can simply cut into their DNA sequences and insert samples of that species' DNA that codes for traits we like. (zmescience.com)

Over the past few decades, the genetic engineering tools available to scientists has expanded to include methods such as mutagenesis and transgenic breeding, the technique used to develop 'genetically modified organisms' (GMOs). (idtechex.com)
Perhaps the most insidious factor in calls for acceptance of the idea of genetically engineering humans is the profound misconception of the nature of living organisms that underlies it. (cbc-network.org)
The proposed rule defines a bioengineered food as a food that "contains genetic material that has been modified through in vitro recombinant deoxyribonucleic acid (DNA) techniques and for which the modification could not otherwise be obtained through conventional breeding or found in nature"-essentially, combining DNA from two different sources, usually two different organisms. (anh-usa.org)
Within organisms , genetic information generally is carried in chromosomes , where it is represented in the chemical structure of particular DNA molecules . (wikipedia.org)

On December 30, 2022, the Turkish Government published a Biosafety Decision to reapprove the import of a genetically engineered (GE) stacked corn event, NK603 X MON 810, for feed. (usda.gov)
The Government of Argentina (GOA) approved two new genetically engineered (GE) events in 2022 (one soybean and one maize). (usda.gov)

IDTechEx research values the crop biotechnology market (i.e., seed produced by different methods of genetic manipulation) at $28.2 billion and forecasts it to reach $44.3 billion by 2031. (idtechex.com)
So the cells have enough time to adapt and find ways to compensate for the consequences of this genetic manipulation. (unibas.ch)
It's short for "clustered regularly interspaced short palindromic repeats," if you must know, and its discovery is opening the door to a massive change, on a global scale, of genetic manipulation and engineering. (sfchronicle.com)
I don't want to get into that fight here, but it is good to see biologist and science writer, Stuart A. Newman, giving purely Darwinian reasons for opposing the manipulation of the human embryo for engineering or transhumanist purposes in the Huffington Post . (cbc-network.org)
As we've written before , we are in the Wild West of genetic manipulation, hacking, and experimentation, and we need laws that can keep up with these advances. (anh-usa.org)
As the demand for biotechnology increases, there has been a concomitant effort into optimizing yield, stability and protein glycosylation through genetic engineering and the manipulation of baculovirus vector and host cells . (bvsalud.org)
From The Island of Dr. Moreau to Bladerunner to Gattaca , the world of sci-fi on the silver screen has had a long interest in genetic manipulation. (zmescience.com)
Genetic manipulation of animals has already gone on for decades, perhaps millennia if you include the way in which we as human beings have domesticated and bred animals to suit our needs. (zmescience.com)

T o apply the word engineering to genetics means that certain skilled humans can change other humans. (christianitytoday.com)
In modern research, genetics provides important tools in the investigation of the function of a particular gene, e.g. analysis of genetic interactions . (wikipedia.org)
Trained in classic and molecular mouse genetics, I was attracted to Genentech by the opportunity to be able to apply genetic tools and genetically engineered murine models to facilitate drug discovery. (gene.com)

Kang Zhou, a DiSTAP principal investigator who is also an assistant professor at the NUS Department of Chemical and Biomolecular Engineering (ChBE) and Xiaoqiang Ma, a postdoctoral associate at SMART, led the development of the technology while working on ways to support their colleagues who were working on enhancing vegetable yield in the country's urban farms. (labmanager.com)

Genetic engineering seems to pit the skills of scientists against the Creator God. (christianitytoday.com)
Scientists are trying to use genetic altering technology to save thousands of lives. (educationindex.com)
Some scientists consider the possibility of modifying the genetic code as a form of 'forward evolution. (khouse.org)
Our ability to provide a voice for scientists and engineers and to advance science depends on the support from individuals like you. (aaas.org)
Shortly after, a slew of genetic advancements came about: in 1978, scientists helped Lesley and John Brown conceive Louise Brown , the first baby born through in vitro fertilization (IVF). (carnegiecouncil.org)
Genetic engineering allows scientists to select one specific gene to implant. (medlineplus.gov)

It should also cause us to seek grace and wisdom from the Almighty that we might be spared the devastating consequences of unwarranted genetic experimentation, and that those who see no difference between tinkering with the genetic code and computer memory chips may experience a moral transformation to bring them under the perfect law of love to God and to all human kind. (christianitytoday.com)

0.19 mg/L), and all were isolated from Center for Genetic Engineering and Bio- cases of invasive disease in France. (cdc.gov)

The main health concerns of genetic modification include virus spread, antibiotic resistance, and allergen effects. (benjaminbarber.org)
Genetic modification should stop and organic farming should be used instead for the future health of the planet. (benjaminbarber.org)
According to Lappee and Bailey (1998) the most common form of genetic modification the chromosomes inside the nucleus which contains the blueprint information for building the plant or fruit. (benjaminbarber.org)
A few of the viruses proposed to be introduced for genetic modification include the rabies virus added to tomatoes to act as a low cost vaccine and the African scorpion virus which is still to be fully understood (eagle. (benjaminbarber.org)
The first meeting in the United States for developing a regulatory framework for genetic modification was held in 1975 at the Asilomar Conference , which outlined voluntary guidelines for the emerging recombinant DNA technology. (carnegiecouncil.org)
Jeffrey M. Smith gave an update on his anti-GMO work, reporting on the current state of genetic modification and the dangers he believes it poses. (coasttocoastam.com)
Directed modification of the gene complement of a living organism by such techniques as altering the DNA , substituting genetic material by means of a virus, transplanting whole nuclei, transplanting cell hybrids, etc. (bvsalud.org)

We can point to the benefits of genetic engineering. (christianitytoday.com)
There are many benefits of genetic engineering, but there are many risks too. (educationindex.com)

Neurofibromatosis type 1 (NF1), also known as peripheral neurofibromatosis or von Recklinghausen disease, is an autosomal dominant genetic condition caused by a mutation in or a deletion of the NF1 gene. (medscape.com)
This genetic mutation is innate, and clinical symptoms appear early in life and continue over many years. (medscape.com)

Through gene engineering, researchers at the Mayo Clinic were able to purge the mice of their senescent cells, effectively slowing the aging effect these old cells have on the tissues. (khouse.org)
Credit: DiSTAP, SMART (MIT's research enterprise in Singapore) Singapore, July 25, 2019 - Researchers at SMART, MIT's research enterprise in Singapore, and National University of Singapore (NUS) have developed a technology that greatly accelerates the genetic engineering of microbes that can be used to manufacture chemicals used for urban farming. (labmanager.com)
In addition to commercialization plans, the researchers are also planning to set up an e-commerce platform which can quickly create and distribute these genetic materials to researchers around the world. (labmanager.com)
Researchers use engineered viruses to provide quantum-based enhancement of energy transport. (mit.edu)
Surprisingly, the MIT researchers achieved this new approach to solar energy not with high-tech materials or microchips - but by using genetically engineered viruses. (mit.edu)
In particular, the support of the International Centre for Genetic Engineering and Biotechnology (Trieste, Italy) in providing fellowships for junior researchers is greatly appreciated. (who.int)
For Dr. McLellan and his team of researchers, the game-changer for the MERS vaccine came with determining, through genetic engineering, how to lock the spike protein in the shape it takes before combining with a human cell. (medlineplus.gov)

Biotechnology & genetic engineering reviews 2023 0 0. (cdc.gov)

However, in recent years, technological advances such as next generation DNA sequencing and gene editing techniques such as TALENs, ZFNs and CRISPR-Cas9 have vastly expanded the capabilities of genetic engineering. (idtechex.com)
Comparison between various gene-delivery systems used for plant genetic engineering. (nanowerk.com)
The authors also discuss challenges and perspectives of nanomaterial-mediated gene-delivery systems to provide new ideas for further optimizing the design and developing novel plant genetic transformation technologies. (nanowerk.com)
Recently, genetic engineering and related disciplines gained fame through capacities granted by gene therapy . (lesswrong.com)
Bioengineered" should be defined to capture the entire gambit of technologies that are used to tamper with the genetic makeup of our food, including gene-editing. (anh-usa.org)
Biotech trees - genetically engineered or gene-edited - offer just that possibility. (ien.com)
Autosomal dominant genetic transmission indicates that one copy of the altered gene is required for phenotypic expression. (medscape.com)
These genetic effects implicate the Ahl gene as contributing to NIHL susceptibility. (cdc.gov)

The large increase in genetically engineered foods has proved to have adverse effects health effects on humans. (benjaminbarber.org)
Even as the techniques of molecular biology have advanced, humans have not yet released a genetically engineered plant that is intended to spread and persist in an unmanaged environment. (ien.com)

By using these tools such as Triple CRISPR or Tol2 transgenesis, we are producing various useful genetic engineered mice within a short period of time. (riken.jp)
Relevance of CRISPR Genetic Engineering for the enhancement of Xenobiotic Degradation and ecorestoration potential of heavily polluted soil 13. (bokkilden.no)

A genetic engineer will identify the chromosome which of the desired trait, which they wish to alter. (benjaminbarber.org)
The maize has more than one genetically engineered trait. (testbiotech.org)
Quantitative trait loci analyses (log of the odds=15) indicated association of the genetic factor within a few centiMorgan of the best evidence for Ahl [Johnson et al. (cdc.gov)

Testbiotech has filed a new legal challenge against EU approval for the import of genetically engineered maize. (testbiotech.org)

Statutes of the International Centre for Genetic Engineering and Biotechnology. (un.org)
Protocol of the Reconvened Plenipotentiary Meeting on the Establishment of the International Centre for Genetic Engineering and Biotechnology. (un.org)
Amendments to Articles 6 (6) and 7(1) of the Statutes of the International Centre for Genetic Engineering and Biotechnology. (un.org)
Protocol to the Statutes of the International Centre for Genetic Engineering and Biotechnology on the Seat of the Centre. (un.org)

The mission of the Genetic Engineering Technologies (GET) group is to provide The Jackson Laboratory's faculty a one stop shop access to technical expertise, instrumentation, and centralized facilities necessary to carry out complex genetic engineering and to create genetically modified mice. (jax.org)
We are fully competent taking a project from concept to delivery of live mice and performing genetic engineering in our laboratories, including allele design, construct development, microinjection, and genotyping of founder mice. (jax.org)
Genetic basis for susceptibility to noise-induced hearing loss in mice. (cdc.gov)

Mr. Woodall's case is a dramatic example of how modern science is making use of DNA - deoxyribonucleic acid - which makes up chromosomes, the complete genetic blueprint found in every cell of living beings. (csmonitor.com)

The new legal challenge is levelled at the import approval for genetically engineered maize produced by Bayer (Monsanto). (testbiotech.org)
The 'stacked' maize which was approved in December 2018 is derived from crossing five genetically engineered maize plants (MON 87427 x MON 89034 x 1507 x MON 88017 x 59122). (testbiotech.org)

This large industry is supporting the work to constantly improve the processes (efficiency, safety and costs) of genetic engineering which will likely ultimately lead to transgenic people. (nextbigfuture.com)

Genetic engineering should only be used in most dire situations, only to cure life threatening diseases. (ipl.org)
On the third day (when the healthy embryos divide to form eight cell embryos), these embryos are biopsied to determine their sex (and whether they have genetic diseases). (bmj.com)
Due to increasing occurrences of distinctive diseases across the globe, the demand for customized or personalized medicines manufactured with the help of genetic engineering is significantly up surged in past few years. (advancemarketanalytics.com)

Last week, I asked how different genetic engineering was from conventional breeding . (grist.org)

The Rise in Pesticide Use," Friends of the Earth and Center for Food Safety ( www.foei.org/en/publications/pdfs/gmcrops2008Q-A.pdf ), February 2008. (organicitsworthit.org)
Grogan and Long (2000) provide that Of the 50 or so genetically engineered plants currently cleared by the government for use, most fall into two basic categories: plants engineered to include their own pesticide, a toxin produced by the BT (Bacillus thuringiensis) bacterium, and the plants engineered to survive weed killers, including the so-called Roundup Ready soybeans and cotton (p. 96). (benjaminbarber.org)
While the GMO experts of EFSA and the EU Commission are of the opinion that the plants are safe, just recently the pesticide experts at EFSA again confirmed there are not enough data to assess the safety of residues left from spraying the genetically engineered plants with glyphosate. (testbiotech.org)
With his appointment, Monsanto and the other pesticide and genetic engineering companies were assured of having plenty of friends and supporters in Washington. (anh-usa.org)

In recent years, breakthroughs in nanotechnology for genetic engineering have provided more favorable tools for the genetic transformation of plants. (nanowerk.com)
The argument, as suggested in the title, is that we've done enough science, and we should stop developing nanotechnology and genetic engineering now, before we lose irrecoverable aspects of our humanity. (softmachines.org)

Genetic engineering is the next scientific advancement that will stand close in the near future. (ipl.org)
Whether you're a scientist, engineer, teacher, or science advocate, together we can be a united voice for scientific progress. (aaas.org)
Although rejection of the realities of evolution is generally considered to be a sign of scientific ignorance, it unfortunately characterizes the thinking of some professional biologists who are strongly influenced by engineering disciplines. (cbc-network.org)
Scientific advancements have dominated much of the 21st century, making it impossible to ignore the ethical implications of advancing genetic procedures. (carnegiecouncil.org)
Indeed, EU regulation requires the safety of genetically engineered plants to be demonstrated in accordance with highest scientific standards before being allowed on to the market. (testbiotech.org)

Available at: https://www.britannica.com/science/genetic- engineering#ref337079. (bvsalud.org)

This has led to much excitement in the field of agricultural biotechnology, with proponents hoping that modern genetic technologies could help usher in a new Green Revolution of agricultural productivity. (idtechex.com)
Throughout the United States and the rest of the globe, genetically engineered food products are becoming increasingly used in agricultural and manufactured food goods. (benjaminbarber.org)
Sustainable farming methods are certainly key, but we will also need marker assisted selection, genetic engineering, agricultural biodiversity, integrated pest management, local food production, grain storage, seed vaults, agricultural education and extension… there is no single solution. (biofortified.org)
Mexico has not officially reported any approvals for genetically engineered (GE) agricultural products for food and feed use since May 2018. (usda.gov)

Whatever the case, detailed examination of an organism's genetic and overall biological characteristics, starting with the process that was used to generate the plants, is needed to demonstrate their safety. (gmwatch.org)

Eligo Bioscience has announced the issuance by the U.S. Patent and Trademark Office (USPTO) of patent #11,473,093 covering genetic engineering of Cutibacterium acnes to support therapeutic interventions in serious skin disorders. (gcimagazine.com)

The technique of recombinant DNA engineering has even caused the barriers between dissimilar species to be broken down. (csmonitor.com)

This market report provides a comprehensive view of the global market for genetic engineering in agriculture, focusing on crop biotechnology. (idtechex.com)
This technology is also applicable to all genetic engineering fields outside of agriculture, and we are actively looking at ways we can deploy it for easy access. (labmanager.com)
Because U.S. national organic standards and industry practices do not allow the use of genetic engineering in the production and processing of organic products, organic agriculture gives consumers who wish to avoid genetically modified foods a choice in the marketplace. (organicitsworthit.org)
Because of the increase of genetically altered foods, an increasing population has become hesitant to accept the products and agriculture derived from genetic engineering. (benjaminbarber.org)
The Cauliflower Mosaic virus is placed in most current genetically engineered agriculture (www. (benjaminbarber.org)
Poland opposes the use of genetic engineering in agriculture. (usda.gov)
7:30pm in CC Theater Unnatural Selection takes us on a panoramic world tour of some of the places that have been most directly impacted by aggressive corporate promotion of genetically engineered agriculture. (uvm.edu)

In 2018, at the request of several U.S. federal agencies and the U.S. Endowment for Forestry and Communities , the National Academies of Sciences, Engineering, and Medicine formed a committee to "examine the potential use of biotechnology to mitigate threats to forest tree health . (ien.com)

In addition to expanding the work on the resurrection of the woolly mammoth, this new round of funding will lead to expanded labs and hiring to support the development of breakthrough genetic editing tools, software, and wetware for use in human health and disease prevention, Wakeford said. (venturebeat.com)

In 2017, the United States spent a whopping 518 million dollars on genetic research alone. (carnegiecouncil.org)
Czech farmers planted genetically engineered (GE) corn from 2005 to 2017. (usda.gov)

ABSTRACT Modern advances in human genetic and reproductive technologies are among the recent developments disturbing the balance between the spiritual and the material components of life. (who.int)
This paper was presented at the International Seminar on "Human Genetic and Reproductive Technologies: Comparing Religious and Secular Perspectives", held in Cairo, Egypt, from 6−9 February 2006. (who.int)
Of the 50 mutants with an epidermal phenotype, 9 map to human genetic conditions with skin abnormalities. (nature.com)

Just because current testing techniques cannot detect GMO material in a finished product does not mean there is no modified genetic material in the food. (anh-usa.org)

Market forecast for genetic technologies in seeds, 2010-2031. (idtechex.com)
Seeds are both natural and engineered, just as we are. (washington.edu)
I know plenty of people who I consider to be smart and reasonable who believe that any critique of genetic engineering of seeds is unfounded conspiratorial thinking. (washington.edu)
Although the current regulatory framework technically allows genetically engineered (GE) seeds to enter commerce, the law stipulates they cannot be planted. (usda.gov)

12- 14 PGD was developed for patients who were at risk of having children with serious genetic disorders such as haemophilia. (bmj.com)
Neurofibromatosis type 1 (NF1) and type 2 (NF2) are neurocutaneous disorders inherited as autosomal dominant genetic syndromes. (medscape.com)
Additional genetic subtypes include progeroid syndromes, autoinflammatory disorders, and SHORT syndrome. (medscape.com)

I kept hoping that something interesting would happen, that the genetic engineering would be given a stronger basis in reality and science, or have some kind of a neat twist to is. (sunpig.com)
I read a lot of science fiction, and the underlying themes of this tale (the future shape and genetic possibilities of mankind) have been explored extensively and to much better effect in books like Greg Bear's "Darwin's Radio", Nancy Kress's "Beggars in Spain", and many others. (sunpig.com)
One most unfortunate product is the type of engineer who does not realize that in order to apply the fruits of science for the benefit of mankind, he must not only grasp the principles of science, but must also know the needs and aspirations, the possibilities and the frailties, of those whom he would serve. (asee.org)
With support from the National Science Foundation1, we created a research and educational experience that focuses on producing engineering graduate students who will be able to understand the social and ethical dimensions of complex, heterogeneous technological systems. (asee.org)
1 The work in this paper was supported by the Social Dimensions of Engineering, Science and Technology program of the National Science Foundation (SBR-9618851) and also by summer research grants from the Colgate Darden School of Business at the University of Virginia and graduate fellowship funding from the School of Engineering & Applied Science at the University of Virginia. (asee.org)
Carnegie Mellon University computer science department head Jeanette Wing, who was selected by the NSF to lead its new Information Science & Engineering Directorate beginning in July, sat down with Computerworld to discuss her vision of the project. (acm.org)
Green Sustainable Process for Chemical and Environmental Engineering and Science: Biosurfactants for the Bioremediation of Polluted Environments explores the use of biosurfactants in remediation initiatives, reviewing knowledge surrounding the creation and application of biosurfactants for addressing issues related to the release of toxic substances in ecosystems. (bokkilden.no)

When he saw Belcher's report on her work with engineered viruses, he wondered if that might provide a way to artificially induce a similar effect, in an effort to approach nature's efficiency. (mit.edu)
Genetic engineering has recently been blamed for new emergence of viruses responsible for reemerging cases of tuberculosis, cholera and malaria and emergence of the Aids, Ebola and Hepatitis C viruses (www. (benjaminbarber.org)
Different types of viruses such as lentivirus, herpes simplex and adeno-associated viruses can be used to genetically engineer individual cells or cellular assemblies. (phys.org)

Moreover, as developed nations generally enjoy a greater level of medical advancement and overall wealth, ethical consideration must be given to how continued advancement of these genetic procedures have the potential to accelerate global health inequality, further aggravating geopolitical power imbalances. (carnegiecouncil.org)

Before genetic engineering became possible, farmers have used simple selection inter- and intraspecies and crossing - for instance, today's strawberries are a cross between a strawberry species native to North America and a strawberry species native to South America. (nanowerk.com)
Spread through the infected genetically engineered species. (benjaminbarber.org)
We're working with nonprofits, conservation groups, governments, and the general public to develop genetic toolkits and support DNA databases to aid in the restoration, diversification and rewilding of endangered species," Wakeford said. (venturebeat.com)

The large amount of genetic information accumulated in the post-genomic era needs to be transformed into knowledge 1 . (nature.com)
Second, the amount of genetic material (RNA) from influenza virus on surgical masks, respirators and gloves worn by health care workers and on the surfaces of equipment and furniture in the clinic will be measured. (cdc.gov)

Genetic engineering of baculovirus-insect cell system to improve protein production. (bvsalud.org)
They used genetic engineering to exchange individual moieties of building blocks and modified the protein chemically using fluorescent dyes. (phys.org)
The human bone morphogenet ic protein (rhBMP) developed by genetic engineering, was isolated by Urist, in 1965, and it is considered a substance capable of inducing differentiation of mesenchymal stem cells into osteoblasts, the cells that are responsible for the synthesis of bone matrix. (bvsalud.org)

The objective of this study was to create a technology that can engineer microbes faster and at a lower cost," said Ma. (labmanager.com)
The new guanine/thymine (GT) DNA assembly technology significantly changes things by enabling genetic engineers to reuse genetic materials. (labmanager.com)
This paper will describe a case study we developed at the University of Virginia for teaching the social and ethical dimensions of technology to engineering students. (asee.org)
At the University of Virginia, we have created a graduate option in Engineering and Ethics that links the Darden Business School, the Division of Technology, Culture and Communications and the Department of Systems Engineering. (asee.org)
Though a multitude of ethical debates arise regarding the genetic technologies themselves, given how much the technology has already advanced, it is most practical to consider regulatory aspects of such advancements and their societal ramifications. (carnegiecouncil.org)
Smith is the founding director of the Institute for Responsible Technology and a member of the Sierra Club Genetic Engineering Committee. (coasttocoastam.com)
Our work will enhance the precision of genetic engineering and advance a technology that may be safer for use in clinical settings. (pewtrusts.org)
Inamuddin is an assistant professor at the Department of Applied Chemistry, Zakir Husain College of Engineering and Technology, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, India. (bokkilden.no)

This paper gives an Islamic perspective on some of these advances, including abortion, in vitro fertilization, genetic engineering, cloning and stem cell research. (who.int)

In order to establish a regulatory framework for genetic technologies, a multitude of ethical dilemmas must be resolved through international cooperation. (carnegiecouncil.org)

The presence of this plant cell wall, which only allows biomolecules with a diameter less than 20 nm to pass through, is limiting the application of nanomaterials in genetic engineering-mediated crop improvement. (nanowerk.com)
Schematic showing nanomaterials developed for plant genetic engineering. (nanowerk.com)

In another study, carbon nanotubes enabled delivery of functional genetic material without DNA integration in mature plants. (nanowerk.com)
In summary, we demonstrate a powerful and scalable research tool for functional genetic studies of human B cell biology that may have further applications in engineered B cell therapeutics. (nih.gov)

Their typical similarity metric is modified to a weighted Euclidean metric and automatically adjusted by a genetic algorithm, a heuristic search (optimization) technique. (bvsalud.org)

Genetic engineered heat resistant DNA polymerases, that have proofreading functions and make fewer mutations in the amplified DNA products, are available commercially. (jrank.org)

In addition, there are specific risks associated with genetically engineered plants if persisting and propagating in the environment. (gmwatch.org)

Anatomy11

Organisms17

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment28

Phenomena and Processes43

Disciplines and Occupations6

Technology, Industry, Agriculture24

Humanities1

Information Science4

Health Care3

Antisense RNA strategies for metabolic engineering of Clostridium acetobutylicum. (1/3961)

Enhanced bioaccumulation of heavy metal ions by bacterial cells due to surface display of short metal binding peptides. (2/3961)

Metabolic engineering of a 1,2-propanediol pathway in Escherichia coli. (3/3961)

Multiple genetic modifications of the erythromycin polyketide synthase to produce a library of novel "unnatural" natural products. (4/3961)

E-CELL: software environment for whole-cell simulation. (5/3961)

Yellow fever/Japanese encephalitis chimeric viruses: construction and biological properties. (6/3961)

A small catalytic RNA motif with Diels-Alderase activity. (7/3961)

Heterologous expression of alkene monooxygenase from Rhodococcus rhodochrous B-276. (8/3961)

Genetic Engineering

Protein Engineering

Tissue Engineering

Metabolic Engineering

Biotechnology

Plants, Genetically Modified

Biomedical Engineering

Theology

Genetic Vectors

Transformation, Genetic

Crops, Agricultural

Molecular Sequence Data

Biofuels

Tissue Scaffolds

Erabutoxins

Genetic Enhancement

Betalains

Gene Transfer Techniques

Escherichia coli

Gene Targeting

Transgenes

Biocompatible Materials

Base Sequence

Plasmids

Recombinant Proteins

Plant Proteins

Recombinant Fusion Proteins

Bioengineering

Amino Acid Sequence

Xylose

Fermentation

Cell Engineering

Metabolic Networks and Pathways

Cloning, Molecular

Agrobacterium tumefaciens

Chemical Engineering

Plastids

Streptomyces

Tobacco

Pest Control, Biological

Recombination, Genetic

Pyruvate Decarboxylase

Integrases

Bacterial Proteins

Gene Expression Regulation, Plant

Droughts

Genetic Therapy

Lignin

Plants

Genes, Plant

Animals, Genetically Modified

Gene Expression

Transduction, Genetic

Models, Molecular

Bioartificial Organs

Chromosomes, Artificial, Bacterial

Antigens, Plant

Multigene Family

Mutation

Mutagenesis

Mutagenesis, Site-Directed

Seeds

Sequence Analysis, DNA

Hydrogels

Synthetic Biology

Oryza sativa

Models, Biological

Porosity

Rhizobium

Photosynthesis

Cells, Cultured

Cell Differentiation

Molecular Structure

DNA

Biodegradation, Environmental

Regenerative Medicine

Materials Testing

Bioreactors

Genes, Bacterial

Zinc Fingers