Bone Transplantation: The grafting of bone from a donor site to a recipient site.Bone Banks: Centers for acquiring, characterizing, and storing bones or bone tissue for future use.Bone and Bones: A specialized CONNECTIVE TISSUE that is the main constituent of the SKELETON. The principle cellular component of bone is comprised of OSTEOBLASTS; OSTEOCYTES; and OSTEOCLASTS, while FIBRILLAR COLLAGENS and hydroxyapatite crystals form the BONE MATRIX.Liver Transplantation: The transference of a part of or an entire liver from one human or animal to another.Transplantation, Homologous: Transplantation between individuals of the same species. Usually refers to genetically disparate individuals in contradistinction to isogeneic transplantation for genetically identical individuals.Bone Marrow Transplantation: The transference of BONE MARROW from one human or animal to another for a variety of purposes including HEMATOPOIETIC STEM CELL TRANSPLANTATION or MESENCHYMAL STEM CELL TRANSPLANTATION.Kidney Transplantation: The transference of a kidney from one human or animal to another.Bone Remodeling: The continuous turnover of BONE MATRIX and mineral that involves first an increase in BONE RESORPTION (osteoclastic activity) and later, reactive BONE FORMATION (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium HOMEOSTASIS. An imbalance in the regulation of bone remodeling's two contrasting events, bone resorption and bone formation, results in many of the metabolic bone diseases, such as OSTEOPOROSIS.Hematopoietic Stem Cell Transplantation: Transfer of HEMATOPOIETIC STEM CELLS from BONE MARROW or BLOOD between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). Hematopoietic stem cell transplantation has been used as an alternative to BONE MARROW TRANSPLANTATION in the treatment of a variety of neoplasms.Transplantation, Autologous: Transplantation of an individual's own tissue from one site to another site.Heart Transplantation: The transference of a heart from one human or animal to another.Lung Transplantation: The transference of either one or both of the lungs from one human or animal to another.Bone Density: The amount of mineral per square centimeter of BONE. This is the definition used in clinical practice. Actual bone density would be expressed in grams per milliliter. It is most frequently measured by X-RAY ABSORPTIOMETRY or TOMOGRAPHY, X RAY COMPUTED. Bone density is an important predictor for OSTEOPOROSIS.Stem Cell Transplantation: The transfer of STEM CELLS from one individual to another within the same species (TRANSPLANTATION, HOMOLOGOUS) or between species (XENOTRANSPLANTATION), or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS). The source and location of the stem cells determines their potency or pluripotency to differentiate into various cell types.Transplantation Conditioning: Preparative treatment of transplant recipient with various conditioning regimens including radiation, immune sera, chemotherapy, and/or immunosuppressive agents, prior to transplantation. Transplantation conditioning is very common before bone marrow transplantation.Graft Survival: The survival of a graft in a host, the factors responsible for the survival and the changes occurring within the graft during growth in the host.Organ Transplantation: Transference of an organ between individuals of the same species or between individuals of different species.Bone Marrow: The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.Bone Resorption: Bone loss due to osteoclastic activity.Bone Marrow Cells: Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.Graft Rejection: An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient.Pancreas Transplantation: The transference of a pancreas from one human or animal to another.Tissue Donors: Individuals supplying living tissue, organs, cells, blood or blood components for transfer or transplantation to histocompatible recipients.Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Transplantation: Transference of a tissue or organ from either an alive or deceased donor, within an individual, between individuals of the same species, or between individuals of different species.Transplantation Immunology: A general term for the complex phenomena involved in allo- and xenograft rejection by a host and graft vs host reaction. Although the reactions involved in transplantation immunology are primarily thymus-dependent phenomena of cellular immunity, humoral factors also play a part in late rejection.Cell Transplantation: Transference of cells within an individual, between individuals of the same species, or between individuals of different species.Transplantation Chimera: An organism that, as a result of transplantation of donor tissue or cells, consists of two or more cell lines descended from at least two zygotes. This state may result in the induction of donor-specific TRANSPLANTATION TOLERANCE.Bone Neoplasms: Tumors or cancer located in bone tissue or specific BONES.Bone Development: The growth and development of bones from fetus to adult. It includes two principal mechanisms of bone growth: growth in length of long bones at the epiphyseal cartilages and growth in thickness by depositing new bone (OSTEOGENESIS) with the actions of OSTEOBLASTS and OSTEOCLASTS.Bone Diseases: Diseases of BONES.Graft vs Host Disease: The clinical entity characterized by anorexia, diarrhea, loss of hair, leukopenia, thrombocytopenia, growth retardation, and eventual death brought about by the GRAFT VS HOST REACTION.Immunosuppressive Agents: Agents that suppress immune function by one of several mechanisms of action. Classical cytotoxic immunosuppressants act by inhibiting DNA synthesis. Others may act through activation of T-CELLS or by inhibiting the activation of HELPER CELLS. While immunosuppression has been brought about in the past primarily to prevent rejection of transplanted organs, new applications involving mediation of the effects of INTERLEUKINS and other CYTOKINES are emerging.Transplantation, Isogeneic: Transplantation between genetically identical individuals, i.e., members of the same species with identical histocompatibility antigens, such as monozygotic twins, members of the same inbred strain, or members of a hybrid population produced by crossing certain inbred strains.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Living Donors: Non-cadaveric providers of organs for transplant to related or non-related recipients.Transplantation, Heterotopic: Transplantation of tissue typical of one area to a different recipient site. The tissue may be autologous, heterologous, or homologous.Cord Blood Stem Cell Transplantation: Transplantation of STEM CELLS collected from the fetal blood remaining in the UMBILICAL CORD and the PLACENTA after delivery. Included are the HEMATOPOIETIC STEM CELLS.Bone Regeneration: Renewal or repair of lost bone tissue. It excludes BONY CALLUS formed after BONE FRACTURES but not yet replaced by hard bone.Heart-Lung Transplantation: The simultaneous, or near simultaneous, transference of heart and lungs from one human or animal to another.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Tissue and Organ Procurement: The administrative procedures involved with acquiring TISSUES or organs for TRANSPLANTATION through various programs, systems, or organizations. These procedures include obtaining consent from TISSUE DONORS and arranging for transportation of donated tissues and organs, after TISSUE HARVESTING, to HOSPITALS for processing and transplantation.Transplantation Tolerance: An induced state of non-reactivity to grafted tissue from a donor organism that would ordinarily trigger a cell-mediated or humoral immune response.Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Bone Matrix: Extracellular substance of bone tissue consisting of COLLAGEN fibers, ground substance, and inorganic crystalline minerals and salts.Peripheral Blood Stem Cell Transplantation: Transplantation of stem cells collected from the peripheral blood. It is a less invasive alternative to direct marrow harvesting of hematopoietic stem cells. Enrichment of stem cells in peripheral blood can be achieved by inducing mobilization of stem cells from the BONE MARROW.Immunosuppression: Deliberate prevention or diminution of the host's immune response. It may be nonspecific as in the administration of immunosuppressive agents (drugs or radiation) or by lymphocyte depletion or may be specific as in desensitization or the simultaneous administration of antigen and immunosuppressive drugs.Histocompatibility Testing: Identification of the major histocompatibility antigens of transplant DONORS and potential recipients, usually by serological tests. Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (King, Dictionary of Genetics, 4th ed)Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)Fetal Tissue Transplantation: Transference of fetal tissue between individuals of the same species or between individuals of different species.Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.Skin Transplantation: The grafting of skin in humans or animals from one site to another to replace a lost portion of the body surface skin.Mesenchymal Stem Cell Transplantation: Transfer of MESENCHYMAL STEM CELLS between individuals within the same species (TRANSPLANTATION, HOMOLOGOUS) or transfer within the same individual (TRANSPLANTATION, AUTOLOGOUS).Transplantation, Heterologous: Transplantation between animals of different species.Recurrence: The return of a sign, symptom, or disease after a remission.Whole-Body Irradiation: Irradiation of the whole body with ionizing or non-ionizing radiation. It is applicable to humans or animals but not to microorganisms.Waiting Lists: Prospective patient listings for appointments or treatments.Bone Diseases, MetabolicHistocompatibility: The degree of antigenic similarity between the tissues of different individuals, which determines the acceptance or rejection of allografts.
The primary treatment for CAMT is bone marrow transplantation. Bone marrow/stem cell transplant is the only remedy for this ... genetic disease. Frequent platelet transfusions are required to keep the patient from bleeding to death until transplant has ... This crosses the bone marrow barrier to the blood and is consumed in the lung by alveolar macrophages. Cytokines are signals ... TPO is primarily synthesized in the liver but can be made by kidneys, testes, brain, and even bone marrow stromal cells. It has ...
The primary treatment for CAMT is bone marrow transplantation. Bone Marrow/Stem Cell Transplant is the only thing that ... ultimately cures this genetic disease. Frequent platelet transfusions are required to ensure that platelet levels do not fall ... Amegakaryocytic Thrombocytopenia research study of Inherited Bone Marrow Failure Syndromes (IBMFS) CAMT Specific Infant Bone ... There is an absence of megakaryocytes in the bone marrow with no associated physical abnormalities. The cause for this disorder ...
The aplastic anemia and immunodeficiency can be treated by bone marrow transplantation. Supportive treatment for ... Genetic counselling. Dyskeratosis congenita Glousker G, Touzot F, Revy P, Tzfati Y, Savage SA (2015). "Unraveling the ... The primary cause of death in HHS is bone marrow failure, but mortality from cancer and pulmonary fibrosis is also significant ... Patients with HHS typically present in early childhood with cerebellar hypoplasia, immunodeficiency, progressive bone marrow ...
Allogenic bone marrow transplantation is possible and genetic therapy is currently under development. The most frequent CGD ... A global approach such as haplotype analysis is probably a better approach to understand the impact of CYBA genetic variability ... and genetic characterization of chronic granulomatous disease in 89 Turkish patients". The Journal of Allergy and Clinical ... "Absence of both the 91kD and 22kD subunits of human neutrophil cytochrome b in two genetic forms of chronic granulomatous ...
Typing for these polymorphisms is routinely done for bone marrow transplantation. Several alleles of HLA-DQB1 are associated ... The locus also has the genetic name IDDM1 as it is the highest genetic risk for type 1 diabetes. Again the DQB1*0201 and DQB1* ... The risk is partially shared with the HLA-DR locus (DR3 and DR4 serotypes). Celiac1 is a genetic name for DQB1, the HLA DQB1* ... Major histocompatibility complex, class II, DQ beta 1, also known as HLA-DQB1, is a human gene and also denotes the genetic ...
"Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey". Lancet. 358 (9278): 271-276 ... There are genetic testing techniques under development to detect any mutation in genes associated with female infertility. ... Many genetic defects (as also detailed previously) also disturb ovarian function. Polycystic ovary syndrome (also see ... Although factors of female infertility can be classified as either acquired or genetic, female infertility is usually more or ...
Pregnancy outcomes after peripheral blood or bone marrow transplantation: a retrospective survey. Lancet. 2001, 358 (9278): 271 ... Sultan C, Biason-Lauber A, Philibert P. Mayer-Rokitansky-Kuster-Hauser syndrome: recent clinical and genetic findings. Gynecol ... 骨塑型蛋白受體 1B(英语:Bone morphogenetic protein receptor 1B). 卵巢功能障礙、高促性腺激素性性腺功能低下症(英语:Hypergonadotropic hypogonadism)、肢端肢中部骨骺
The only treatment for Omenn syndrome is chemotherapy followed by a bone marrow transplantation. Without treatment, it is ... "The genetic and biochemical basis of Omenn syndrome". Immunol Rev. 178: 64-74. doi:10.1034/j.1600-065X.2000.17818.x. PMID ...
... allogeneic bone marrow transplantation may be curative. The prognosis is generally poor. The RS score (Richter syndrome score ... It is thought that genetic defects may introduce the additional abnormalities necessary to transform CLL cells into Richter's ... in Patients With Richter's Syndrome Treated With Chemotherapy or Chemoimmunotherapy With or Without Stem-Cell Transplantation ...
... high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation". Blood ... An example target for targeted therapy is the protein produced by the Philadelphia chromosome, a genetic lesion found commonly ... "Biology of Blood and Marrow Transplantation. 15 (12): 1628-33. PMC 2861656 . PMID 19896087. doi:10.1016/j.bbmt.2009.07.004.. ... Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. 72: 39-41. doi:10.1001/ ...
1987). "Bone marrow transplantation in the treatment of alpha-mannosidosis". Disease in Childhood. 62 (10): 1044-1049. doi: ... a b c d e f g h Borgwardt L, Lund AM, Dali CI (2014). Alpha-mannosidosis - a review of genetic, clinical findings and options ... 2004).Effective treatment of alpha-mannosidosis by allogeneic hematopoietic stem cell transplantation. J Pediatr, 144:569-573. ... C. Genetic testing Identification of disease-causing mutations is achieved using DNA from peripheral blood cells, by polymerase ...
... high-dose cyclophosphamide with or without high-dose busulfan or total-body irradiation and bone marrow transplantation". Blood ... These factors lead to accumulations of genetic mutations in oncogenes (genes that control the growth rate of cells) and tumor ... Krumbhaar EB (1919). "Role of the blood and the bone marrow in certain forms of gas poisoning". JAMA. 72: 39-41. doi:10.1001/ ... Arnon J, Meirow D, Lewis-Roness H, Ornoy A (2001). "Genetic and teratogenic effects of cancer treatments on gametes and embryos ...
Kay HE (November 1982). "Bone marrow transplantation: 1982". British Medical Journal. 285 (6351): 1296-8. doi:10.1136/bmj. ... A multi-locus genetic risk score study based on a combination of 27 loci, including the ABO gene, identified individuals at ... Yamamoto F, Clausen H, White T, Marken J, Hakomori S (May 1990). "Molecular genetic basis of the histo-blood group ABO system ... Yamamoto F, McNeill PD, Yamamoto M, Hakomori S, Harris T (1993). "Molecular genetic analysis of the ABO blood group system: 3. ...
Signs of progressive marrow failure may warrant bone marrow transplantation (BMT). This has been used successfully to treat ... The gene responsible for the disease has been identified and genetic testing is now available. Though useful in diagnostics, a ... Bone marrow is typically hypocellular, with maturation arrest in the myeloid lineages that give rise to neutrophils, ... Shwachman H, Diamond LK, Oski FA, Khaw KT (1964). "The syndrome of pancreatic insufficiency and bone marrow dysfunction". J ...
Kay, H E (1982-11-06). "Bone marrow transplantation: 1982". British Medical Journal (Clinical research ed.). 285 (6351): 1296- ... A multi-locus genetic risk score study based on a combination of 27 loci, including the ABO gene, identified individuals at ... Morgan, W. T. J.; Watkins, W. M (1969). "Genetic and biochemical aspects of human blood-group A-, B-, H-, Le-a- and Le-b- ... 1990). "Molecular genetic basis of the histo-blood group ABO system". Nature. 345: 229-233. doi:10.1038/345229a0. PMID 2333095 ...
A new development, announced by the University of Cincinnati Medical School in May 2007, would use bone marrow stem cells to ... This technique, which proved successful in mouse trials, would be of use to those suffering from inherited genetic degenerative ... Corneal transplantation, also known as corneal grafting, is a surgical procedure where a damaged or diseased cornea is replaced ... Corneal transplantation. Cornea transplant approximately one week after surgery. Multiple light reflections indicate folds in ...
Contrast agents used in imaging studies as well as transplantation of bone marrow or organs have also been linked to TEN ... Certain genetic factors are associated with increased risk of TEN. For example, certain HLA-types such as, HLA-B*1502, HLA-A* ...
Bone Marrow Transplantation and Peripheral Blood Stem Cell Transplantation In National Cancer Institute Fact Sheet web site. ... After the donor somatic cell genetic material is transferred into the host oocyte with a micropipette, the somatic cell genetic ... Bone marrow transplantation is a widely used form of stem cell therapy.[28] No other forms of stem cell therapy are in clinical ... Robin Cook's 1997 novel Chromosome 6 and Michael Bay's The Island are examples of this; Chromosome 6 also features genetic ...
CLL is treated by chemotherapy, radiation therapy, biological therapy, or bone marrow transplantation. Symptoms are sometimes ... Some relevant genetic mutations may be inherited; in around 9% of CLL cases a parent had CLL. Exposure to Agent Orange ... In this case, more aggressive therapies, including lenalidomide, flavopiridol, and bone marrow (stem cell) transplantation, are ... bone marrow killing) forms of allogeneic stem cell transplantation, a high-risk treatment using blood cells from a healthy ...
Unlike bone marrow transplantation, cord blood transplantation doesn't require an exact genetic match, which makes it easier to ... Recent studies have shown that cord blood has unique advantages over traditional bone marrow transplantation, particularly in ... Bone marrow transplants require a complete match on six key antigens, which are measures of graft-versus-host reaction, known ... The odds that two siblings will have the 6/6 match required for a bone marrow transplant are 25%. The odds that two siblings ...
They can be treated only by lifelong blood transfusion and bone marrow transplantation. Reduced HBB function called thalassemia ... Mutations in the gene produce several variants of the proteins which are implicated with genetic disorders such as sickle-cell ... Total or partial absence of HBB causes a genetic disease called beta thalassemia. Total loss called, thalassemia major or beta- ... Homozygous allele has become one of the deadliest genetic factors. Whereas, people heterozygous for the mutant allele (HbS/HbA ...
Potential cures include bone marrow transplantation and gene therapy. Congenital dyserythropoietic anemia Thalassemia ... The genetic cause of CDA type III is known to be a problem with the KIF23 gene, located on the long arm of chromosome 15 at a ... bone marrow erythroid hyperplasia and giant multinucleate erythroblasts. New evidence suggests that this may be passed on ... Genetic Home References Sandstrom entry on Congenital Dyserythropoietic Anemia Type III Congenital dyserythropoietic anemia at ...
Potential cures include bone marrow transplantation and gene therapy. Congenital dyserythropoietic anemia Thalassemia ... Dyserythropoietic Anemia Type I Congenital dyserythropoietic anemia at the US National Institutes of Health Home Genetic ...
Bone marrow transplantation is the only cure and is indicated for patients with severe thalassemia major. Transplantation can ... Gene Expression and Genetic Engineering, and Mutations and Human Genetic. Universal-Publishers. ISBN 9781612331928. Weatherall ... "HLA-matched sibling bone marrow transplantation for β-thalassemia major". Blood. 117 (5): 1745-1750. doi:10.1182/blood-2010-09- ... Bone marrow transplants can be curative for some children. Patients receive frequent blood transfusions that lead to or ...
... the Director of Bone Marrow Transplantation, Cell Therapy and Transplantation Research Center at Hadassah felt that all ... conduct a preclinical study of PLX-R18 cells in umbilical cord blood transplants for the treatment of blood cancers and genetic ... Compassionate Use of Pluristem's PLX Cells Saves the Life of a Child After Bone Marrow Transplantation Failure". Benzinga. ... In September 2012 Pluristem reported saving the life of a third bone marrow disease patient using its PLacental eXpanded cell ...
In 1990, only six African-Americans were able to find a bone marrow match, and all six had common European genetic signatures.[ ... "Bone Marrow Transplant" redirects here. For the journal abbreviated Bone Marrow Transplant, see Bone Marrow Transplantation ( ... Bone marrow transplantation usually requires that the recipient's own bone marrow be destroyed (myeloablation). Prior to the ... Wikimedia Commons has media related to Hematopoietic stem cell transplantation.. *Bone marrow transplant - How it is performed ...
... recognized as a leader in the field of cord blood stem cell transplantation, has joined the team at CORD:USE Cord Blood Bank. ... who has led the development of the field of in utero stem cell transplantation and gene therapy as a means for curing genetic ... Levine was responsible for initiating the bone marrow and umbilical cord blood research programs at the NIH. ... John Wagner, M.D., recognized as a leader in the field of cord blood stem cell transplantation, has joined the team at CORD:USE ...
Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ... Genetic Testing of Diseases. Genetic testing helps to confirm a genetic condition in an individual and involves q complex ... Genetics and Stem Cells Acute Lymphoblastic Leukemia Genetic Testing of Diseases Multiple Myeloma Bone Marrow Transplantation ... Genetic Mutation Increases Risk of Recurrence in Some Older Patients With Acute Leukemia. ...
Bone Marrow Transplantation. Preferred Term is Hematopoietic stem cell transplantation. In this stem cell from bone marrow are ... Fundamentals Parkinsons Disease Surgical Treatment Genetics and Stem Cells Bone Marrow Transplantation Tissue Engineering and ... Illness-Linked Genetic Variation That Affect Neurons Revealed by Stem Cells. by Himabindu Venkatakrishnan on August 18, 2014 at ... To make sure that the differences were really due to the DISC1 variation and not to other genetic differences, graduate student ...
A model for the dosage adjustment with the inclusion of genetic and non-genetic factors should be evaluated in a future ... Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantation. Bone Marrow Transplant 2001; ... Bone Marrow Transplantation volume 48, pages939-946(2013)Cite this article ... Genetic and non-genetic factors explained 26% of EFS variability (with 11% of GSTA1*A2 contribution, P=0.05), 26% of VOD ...
Bone marrow transplantation (1). * Encephalopathy (1). * Genetic variation (1). Date ​ Choose a date option to show results ... Bone Marrow Transplantation 23 , 569-572 Rights & permissionsfor article Allogeneic hematopoietic stem cell transplantation for ... Bone Marrow Transplantation 47 , 1381-1382 Rights & permissionsfor article Posterior reversible encephalopathy syndrome in a ... Allogeneic hematopoietic stem cell transplantation for patients with hemophagocytic syndrome (HPS) in Japan *S Imashuku ...
Transplantation. 2004 Aug 27;78(4):503-8. Research Support, Non-U.S. Govt ... Genetic Testing Registry. *Influenza Virus. *Online Mendelian Inheritance in Man (OMIM). *PubMed ... Transplantation. 2004 Aug 27;78(4):503-8.. Dynamic of distribution of human bone marrow-derived mesenchymal stem cells after ... models have demonstrated that the syngeneic or xenogeneic transplantation of MSC results in donor engraftment into the bone ...
Genetic control of bone marrow transplantation in irradiated mice. Classification of mouse strains according to their ... Lotzova, E; Dicke, K A.; Trentin, J J.; and Gallagher, M T., "Genetic control of bone marrow transplantation in irradiated mice ... Hereditary Factors:, Organs:, Serology: Antigen,, Transplantation:, Congenic Resistant Lines: B10.A, B10.BR, B10.D2/O, Genes: H ... Classification of mouse strains according to their responsiveness to bone marrow allografts and xenografts." (1977). Subject ...
MedlinePlus related topics: Bone Marrow Transplantation Genetic and Rare Diseases Information Center resources: Sickle Cell ... Procedure: Bone marrow transplantation Day 0 - Transplantation of hematopoietic cells derived from bone marrow of a donor to a ... Non-Myeloablative Conditioning and Bone Marrow Transplantation. The safety and scientific validity of this study is the ... Experimental: Non-Myeloablative Conditioning and Bone Marrow Transplantation Drug: Thymoglobulin Day 9 - 0.5 mg/kg IV before ...
Genetic and Rare Diseases Information Center resources: Retinitis Pigmentosa Cone-rod Dystrophy Cone-rod Dystrophy 2 ... Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa. The safety and scientific validity of this ... Phase 1 Study Of Autologous Bone Marrow-Derived Stem Cells Transplantation For Retinitis Pigmentosa. ... The purpose of this study is to evaluate the short-term safety of a single intravitreal injection of autologous bone marrow ...
Intervention Details: Genetic: allogeneic mesenchymal stem cell transplantation 1.000.000(one million) cells/kg, IV (1/2 of ... Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic ... Efficacy of Invitro Expanded Bone Marrow Derived Allogeneic Mesenchymal Stem Cell Transplantation Via Portal Vein or Hepatic ... liver biopsies performed at sixth month after mesenchymal stem cell transplantation ]. all patients will be transplanted bone ...
... the literature using bone marrow transplantation has produced inconsistent results. AT1a receptor deficiency in bone marrow- ... This has also been combined with bone marrow transplantation to elucidate the role of a specific AngII receptor on cells on ... However, one study has used genetic deficiency of renin to determine the contribution of this enzyme activity in bone marrow- ... The effect of AT1a receptors on atherosclerosis has also been studied using bone marrow transplantation. It has primarily been ...
PF756 DONOR UNC-93 HOMOLOG B1 GENETIC VARIATION PREDICTS SURVIVAL OUTCOMES AFTER UNRELATED BONE MARROW TRANSPLANTATION. Uchino ... PF756 DONOR UNC-93 HOMOLOG B1 GENETIC VARIATION PREDICTS SURVIVAL OUTCOMES AFTER UNRELATED BONE MARROW TRANSPLANTATION. Uchino ... PF758 MULTI-CENTER, PHASE II STUDY ON HAPLOIDENTICAL BONE MARROW TRANSPLANTATION USING A RIC REGIMEN AND POST-TRANSPLANT ... PS1367 COMPREHENSIVE GENETIC ANALYSIS OF MULTIPLE MYELOMA IN JAPAN. Kanamori, T.; Sanada, M.; Ri, M.; More ...
Genetic and Rare Diseases Information Center resources: Multiple Myeloma U.S. FDA Resources ... Experimental: Transplantation Single arm combined bone marrow and kidney transplantation. Drug: Tacrolimus Tacrolimus starting ... Combined Bone Marrow and Renal Transplantation for Hematologic Disorders With End Stage Renal Disease. The safety and ... Standard bone marrow transplantation is associated with prohibitive toxicities in patients with end stage renal disease, and is ...
Transplantation immunology: organ and bone marrow. J Allergy Clin Immunol 2003;111(Suppl 2):S733--44. ... Evaluation of Genetic Tests. In 1999, the National Institutes of Health (NIH)-U.S. Department of Energy Task Force on Genetic ... Genetic Tests and PI Diseases. Advances in molecular biology and genetic technology have facilitated localization of disease ... Buckley RH, Fischer A. Bone marrow transplantation for primary immunodeficiency diseases. In: Ochs HD, Smith CIE, Puck JM, eds ...
Genetic Disorders of Haemoglobin 7. Aplastic Anaemia and Bone Marrow Failure 8. Stem Cell Transplantation 9. The White Cells 1 ... Genetic Disorders Of Haemoglobin7. Aplastic Anaemia And Bone Marrow Failure8. Stem Cell Transplantation9. The White Cells 1: ... is covered in individual chapters as well as in an expanded section on bone marrow transplantation and the management of bone ... is covered in individual chapters as well as in an expanded section on bone marrow transplantation and the management of bone ...
Those with severe thalassemia may require bone marrow transplantation. Genetic therapy is is being investigated and may soon be ... Those with severe thalassemia may require bone marrow transplantation. Genetic therapy is being investigated and may soon be ... Aplastic anemia can sometimes be cured by bone marrow transplantation. If the condition is due to immunosuppressive drugs, ... Radiation therapy to large areas of bone marrow, as in the hip area, may suppress bone marrow function and lead to anemia. ...
... cases after bone marrow stem cell transplantation. Measured by the American Spinal Injury Association (ASIA) scale, 7 (78%) out ... The bone marrow was aspirated from the anterior iliac crest under local anesthesia and the mononuclear fraction was isolated by ... Analysis of subsequent treatment results indicated that the transplantation of mononuclear-enriched autologous BMSCs is a ... A. I. Farbman, "Olfactory neurogenesis: genetic or environmental controls?" Trends in Neurosciences, vol. 13, no. 9, pp. 362- ...
Bone Marrow Transplantation* * Female * Gene Expression * Genetic Therapy / methods* * Green Fluorescent Proteins ... We have shown previously that up to 20% of lung epithelial cells can be derived from marrow following BMSC transplantation. ... We investigate the novel approach of using retrovirally transduced multipotent bone marrow-derived stem cells (BMSC) to deliver ...
diseases of the spine; and improving outcomes of bone marrow transplantation associated with oncology or genetic conditions. ... and cord blood expansion in bone marrow transplantation). ... The transplant is derived from donated bone marrow, cord blood ... Prochymal® is an intravenous preparation of MSCs using MSCs isolated from the bone marrow of healthy young adult donors. They ... A peer-reviewed article in the November 2013 scientific journal Biology of Blood and Marrow Transplantation reported that use ...
11-16 Bone marrow transplantation or gene therapy can be useful to correct genetic defects ... Bone marrow transplantation or gene therapy can be useful to correct genetic defects ... 11-19 Genetic deficiency of the macrophage chemokine co-receptor for HIV confers resistance to HIV infection in vivo ... Genetic deficiency of the macrophage chemokine co-receptor for HIV confers resistance to HIV infection in vivo ...
... and improving outcomes of bone marrow transplantation associated with oncology or genetic conditions. www.mesoblast.com ...
Hematopoietic Stem Cell Transplantation. *Bone Marrow Transplantation. *Bone Marrow Failure. *Inherited Genetic Diseases ... Allogenic Bone Marrow Transplantation (BMT), Metabolic Diseases, Hurler Syndrome. For more information, please visit our lab ... Rare Genetic Diseases, Bone Marrow Failure, Aplastic Anemia, Genomics, Fanconi Anemia (FA), Immunodeficiency (SCID), ... Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches SCIENCE Czechowicz, A., Kraft, D., ...
HEREDITY CONCEPT Heredity is the transmission of genetic characteristics from ancestor to descendant through the genes. As a ... The only known cure for SCID is bone marrow transplantation from a close relative. Short of a cure, patients may be forced to ... 2. the genetic properties and phenomena of an organism. -geneticist , n. -genetic , adj. hereditist a believer in the theory ... GENETIC DOMINANCE:. The ability of a single allele to control phenotype.. GENOTYPE:. The sum of all genetic input to a ...
Bone marrow transplantation - organ allograft.. * Therapeutic radiation.. Genetic Factors. * Patients own history of melanoma. ... Pathologic bone fracture of long bone (weight bearing) - surgery and radiation therapy. ... In the past, bone involvement had been considered to be infrequent. More recently, with widespread use of PET scanning, it has ... Genetic Factors*Gender/race. *What laboratory and imaging studies should you order to characterize this patients tumor (ie, ...
Access to advanced bone marrow stem cell transplantation techniques *Warm and knowledgeable support staff members on our MDS ... Previously, our researchers helped characterize the range of genetic changes in MDS patients by studying bone marrow samples ... Myelodysplastic syndromes (MDS) are diseases of the blood and bone marrow. In a healthy person, bone marrow stem cells divide ... A bone marrow aspirate and biopsy is typically required to make the diagnosis. Your doctor will combine this information with a ...
  • Major drivers for this transaction were Mesoblast's evaluation of the use of Prochymal® for inflammatory diseases of the bowel, including patients with Crohn's Disease who have failed other biologic agents and patients with potentially life-threatening Graft Versus Host Disease (GVHD) involving the gut and liver after a bone marrow transplant. (cnbc.com)
  • Doctors are faced with a difficult choice: Either remove the T cells from the bone marrow, increasing the risk of infection, or leave the T cells in the graft, putting the patient at risk for lethal graft-versus-host disease. (healthcanal.com)
  • Because there is diminished risk of graft-versus-host disease after transplantation of cord stem cells using matched related donors, the use of less-than-completely matched HLA cord blood stem cells may incur less risk of graft-versus-host disease than mismatched cells from either a related or unrelated "walking" donor, although this remains to be proven. (aappublications.org)
  • Elucidating the genetic pathways and molecular networks that are perturbed in t-MNs, may facilitate the identification of therapeutic targets that can be exploited for the development of urgently-needed targeted therapies. (ebscohost.com)
  • Even monozygotic twins (who develop from one zygote) have infrequent genetic differences due to mutations occurring during development and gene copy-number variation . (wikipedia.org)
  • A second important process is genetic drift , which is the effect of random changes in the gene pool, under conditions where most mutations are neutral (that is, they do not appear to have any positive or negative selective effect on the organism). (wikipedia.org)
  • [ citation needed ] The second main cause of genetic variation is due to the high degree of neutrality of most mutations . (wikipedia.org)
  • For decades physicians have known that a few children like Ceniya have unusual genetic mutations that counteract the effects of the sickle-cell flaw. (scientificamerican.com)
  • Moreover, Prof. Or serves as the Medical Director of the Volunteer Bone Marrow Bank and also as the Medical Director of the Israeli National Public Umbilical Cord Blood Bank. (isracast.com)
  • In addition to concerns about a recurrence of the cancer for which they were treated, cancer survivors are also at increased risk of developing a second type of cancer because of either their treatment for cancer (e.g., radiation), their genetic or other susceptibility, or some interaction between treatment and genetic susceptibility. (nap.edu)
  • The diagnosis of leukemia is supported by findings of the medical history and examination, and examining blood and bone marrow samples under a microscope. (medicinenet.com)
  • Acute myeloid leukemia, a cancer of the bone marrow and blood, occurs most frequently in adults over the age of 60. (cancer.gov)
  • But earlier studies by Dr. Meshinchi and his colleagues showed that some of the most common genetic features of adult AML are completely absent in childhood AML, suggesting that the biological characteristics of this leukemia may differ by patient age. (cancer.gov)
  • Although genetic factors underlying traditional risk factors are well known, 2 new data emerging from genome-wide association studies are revealing novel loci mediating disease susceptibility independent of traditional factors. (ahajournals.org)
  • We have used a murine genetic approach to map atherosclerosis susceptibility loci, including a locus on mouse chr 4 that was confirmed in a congenic strain. (ahajournals.org)
  • Five minutes of cleansing with a 10% povidone-iodine solution followed by a normal saline solution rinse appears to provide the optimal balance between effective decontamination and cellular toxicity for dropped autologous bone in the operative setting. (ebscohost.com)
  • Prof. Reuven Or, the director of the Center for Stem Cell Ttransplantation, Research, and Development, completed his fellowship in hematology/oncology at the Hadassah University Medical Center where he specialized in bone marrow transplantation. (isracast.com)
  • Today, more and more families are choosing Cincinnati Children's, a special place where hematology, oncology, bone marrow transplantation, immune deficiency and vascular malformation experts have earned a strong reputation for providing sophisticated, family-centered treatments and cutting-edge research. (cincinnatichildrens.org)
  • Methods and apparatus are presented for extracting and collecting bone marrow from the jawbone of a patient before, during, or after dental procedures. (google.es)
  • The method and apparatus further provides a readily accessible, and easily harvested, source of bone marrow without the drawbacks of current extraction methods. (google.es)
  • The present invention relates generally to methods and apparatus for recovering bone marrow from a patient and subsequent collection and storage. (google.es)
  • Bone marrow and bone are anatomically contiguous tissues that show parallel age-related changes and share several genetic features ( 9 - 11 ), suggesting a close developmental relationship. (pnas.org)
  • More specifically, the present invention relates to a method of obtaining bone marrow and bone marrow fluid from the jawbone of a patient with relative ease and minor discomfort before, during, or after dental procedures, such as the removal of impacted or redundant third molars or bicuspids for long term storage and/or for bone typing. (google.es)
  • In support of this latter scenario, it has recently been reported that acute infection with lymphocytic choriomeningitis virus (LCMV) 4 Armstrong at the time of transplantation prevents tolerance induction and induces rapid graft rejection ( 5 , 6 ). (jimmunol.org)