Genes fungal. Medical search

SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. (1/10689)

Meiosis in Saccharomyces cerevisiae is followed by encapsulation of haploid nuclei within multilayered spore walls. Formation of this spore-specific wall requires the coordinated activity of enzymes involved in the biosynthesis of its components. Completion of late events in the sporulation program, leading to spore wall formation, requires the SWM1 gene. SWM1 is expressed at low levels during vegetative growth but its transcription is strongly induced under sporulating conditions, with kinetics similar to those of middle sporulation-specific genes. Homozygous swm1Delta diploids proceed normally through both meiotic divisions but fail to produce mature asci. Consistent with this finding, swm1Delta mutant asci display enhanced sensitivity to enzymatic digestion and heat shock. Deletion of SWM1 specifically affects the expression of mid-late and late sporulation-specific genes. All of the phenotypes observed are similar to those found for the deletion of SPS1 or SMK1, two putative components of a sporulation-specific MAP kinase cascade. However, epistasis analyses indicate that Swm1p does not form part of the Sps1p-Smk1p-MAP kinase pathway. We propose that Swm1p, a nuclear protein, would participate in a different signal transduction pathway that is also required for the coordination of the biochemical and morphological events occurring during the last phase of the sporulation program. (+info)

NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. (2/10689)

A mutation in NMD3 was found to be lethal in the absence of XRN1, which encodes the major cytoplasmic exoribonuclease responsible for mRNA turnover. Molecular genetic analysis of NMD3 revealed that it is an essential gene required for stable 60S ribosomal subunits. Cells bearing a temperature-sensitive allele of NMD3 had decreased levels of 60S subunits at the nonpermissive temperature which resulted in the formation of half-mer polysomes. Pulse-chase analysis of rRNA biogenesis indicated that 25S rRNA was made and processed with kinetics similar to wild-type kinetics. However, the mature RNA was rapidly degraded, with a half-life of 4 min. Nmd3p fractionated as a cytoplasmic protein and sedimented in the position of free 60S subunits in sucrose gradients. These results suggest that Nmd3p is a cytoplasmic factor required for a late cytoplasmic assembly step of the 60S subunit but is not a ribosomal protein. Putative orthologs of Nmd3p exist in Drosophila, in nematodes, and in archaebacteria but not in eubacteria. The Nmd3 protein sequence does not contain readily recognizable motifs of known function. However, these proteins all have an amino-terminal domain containing four repeats of Cx2C, reminiscent of zinc-binding proteins, implicated in nucleic acid binding or protein oligomerization. (+info)

Characterization and expression of the cDNA encoding a new kind of phospholipid transfer protein, the phosphatidylglycerol/phosphatidylinositol transfer protein from Aspergillus oryzae: evidence of a putative membrane targeted phospholipid transfer protein in fungi. (3/10689)

The full-length cDNA of a phospholipid transfer protein (PLTP) was isolated from Aspergillus oryzae by a RACE-PCR procedure using degenerated primer pool selected from the N-terminal sequence of the purified phosphatidylinositol/phosphatidylglycerol transfer protein (PG/PI-TP). The cDNA encodes a 173 amino acid protein of 18823 Da. The deduced amino acid sequence from position 38 to 67 is 100% identical to the N-terminal sequence (first 30 amino acids) of the purified PG/PI-TP. This amino acid sequence is preceded by a leader peptide of 37 amino acids which is predicted to be composed of a signal peptide of 21 amino acids followed by an extra-sequence of 16 amino acids, or a membrane anchor protein signal (amino acid 5-29). This strongly suggests that the PG/PI-TP is a targeted protein. The deduced mature protein is 138 amino acids long with a predicted molecular mass of 14933 Da. Comparison of the deduced PG/PI-TP sequence with other polypeptide sequences available in databases revealed a homology with a protein deduced from an open reading frame coding for an unknown protein in Saccharomyces cerevisiae (36% identity and 57% similarity). Apart from this homology, the PG/PI-TP is unique and specific to the filamentous fungi on the basis of comparison of PLTP protein sequences. Northern blot analysis of RNA isolated from A. oryzae cultures grown on glucose or glucose supplemented with phospholipids suggests that the PG/PI-TP is transcribed by only one RNA species and allows us to show that expression of the protein is regulated at the messenger RNA level. (+info)

Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (4/10689)

In HeLa cells, the tRNA processing enzyme ribonuclease P (RNase P) consists of an RNA molecule associated with at least eight protein subunits, hPop1, Rpp14, Rpp20, Rpp25, Rpp29, Rpp30, Rpp38, and Rpp40. Five of these proteins (hPop1p, Rpp20, Rpp30, Rpp38, and Rpp40) have been partially characterized. Here we report on the cDNA cloning and immunobiochemical analysis of Rpp14 and Rpp29. Polyclonal rabbit antibodies raised against recombinant Rpp14 and Rpp29 recognize their corresponding antigens in HeLa cells and precipitate catalytically active RNase P. Rpp29 shows 23% identity with Pop4p, a subunit of yeast nuclear RNase P and the ribosomal RNA processing enzyme RNase MRP. Rpp14, by contrast, exhibits no significant homology to any known yeast gene. Thus, human RNase P differs in the details of its protein composition, and perhaps in the functions of some of these proteins, from the yeast enzyme. (+info)

The Saccharomyces cerevisiae CWH8 gene is required for full levels of dolichol-linked oligosaccharides in the endoplasmic reticulum and for efficient N-glycosylation. (5/10689)

The Saccharomyces cerevisiae mutant cwh8 was previously found to have an anomalous cell wall. Here we show that the cwh8 mutant has an N -glycosylation defect. We found that cwh8 cells were resistant to vanadate and sensitive to hygromycin B, and produced glycoforms of invertase and carboxypeptidase Y with a reduced number of N -chains. We have cloned the CWH8 gene. We found that it was nonessential and encoded a putative transmembrane protein of 239 amino acids. Comparison of the in vitro oligosaccharyl transferase activities of membrane preparations from wild type or cwh8 Delta cells revealed no differences in enzyme kinetic properties indicating that the oligosaccharyl transferase complex of mutant cells was not affected. cwh8 Delta cells also produced normal dolichols and dolichol-linked oligosaccharide intermediates including the full-length form Glc3Man9GlcNAc2. The level of dolichol-linked oligosaccharides in cwh8 Delta cells was, however, reduced to about 20% of the wild type. We propose that inefficient N -glycosylation of secretory proteins in cwh8 Delta cells is caused by an insufficient supply of dolichol-linked oligosaccharide substrate. (+info)

Identification of yeasts by RFLP analysis of the 5.8S rRNA gene and the two ribosomal internal transcribed spacers. (6/10689)

The identification and classification of yeasts have traditionally been based on morphological, physiological and biochemical traits. Various kits have been developed as rapid systems for yeast identification, but mostly for clinical diagnosis. In recent years, different molecular biology techniques have been developed for yeast identification, but there is no available database to identify a large number of species. In the present study, the restriction patterns generated from the region spanning the internal transcribed spacers (ITS1 and ITS2) and the 5.8S rRNA gene were used to identify a total of 132 yeast species belonging to 25 different genera, including teleomorphic and anamorphic ascomycetous and basidiomycetous yeasts. In many cases, the size of the PCR products and the restriction patterns obtained with endonucleases CfoI, HaeIII and HinfI yielded a unique profile for each species. Accordingly, the use of this molecular approach is proposed as a new rapid and easy method of routine yeast identification. (+info)

The genes for the Golgi apparatus N-acetylglucosaminyltransferase and the UDP-N-acetylglucosamine transporter are contiguous in Kluyveromyces lactis. (7/10689)

The mannan chains of Kluyveromyces lactis mannoproteins are similar to those of Saccharomyces cerevisiae except that they lack mannose phosphate and have terminal alpha(1-->2)-linked N-acetylglucosamine. Previously, Smith et al. (Smith, W. L. Nakajima, T., and Ballou, C. E. (1975) J. Biol. Chem. 250, 3426-3435) characterized two mutants, mnn2-1 and mnn2-2, which lacked terminal N-acetylglucosamine in their mannoproteins. The former mutant lacks the Golgi N-acetylglucosaminyltransferase activity, whereas the latter one was recently found to be deficient in the Golgi UDP-GlcNAc transporter activity. Analysis of extensive crossings between the two mutants led Ballou and co-workers (reference cited above) to conclude that these genes were allelic or tightly linked. We have now cloned the gene encoding the K. lactis Golgi membrane N-acetylglucosaminyltransferase by complementation of the mnn2-1 mutation and named it GNT1. The mnn2-1 mutant was transformed with a 9.5-kilobase (kb) genomic fragment previously shown to contain the gene encoding the UDP-GlcNAc transporter; transformants were isolated, and phenotypic correction was monitored after cell surface labeling with fluorescein isothiocyanate-conjugated Griffonia simplicifolia II lectin, which binds terminal N-acetylglucosamine, and a fluorescence-activated cell sorter. The above 9.5-kb DNA fragment restored the wild-type lectin binding phenotype of the transferase mutant; further subcloning of this fragment yielded a smaller one containing an opening reading frame of 1,383 bases encoding a protein of 460 amino acids with an estimated molecular mass of 53 kDa, which also restored the wild-type phenotype. Transformants had also regained the ability to transfer N-acetylglucosamine to 3-0-alpha-D-mannopyranosyl-D-mannopyranoside. The gene encoding the above transferase was found to be approximately 1 kb upstream from the previously characterized MNN2 gene encoding the UDP-GlcNAc Golgi transporter. Each gene can be transcribed independently by their own promoter. To our knowledge this is the first demonstration of two Golgi apparatus functionally related genes being contiguous in a genome. (+info)

The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. (8/10689)

The mdm17 mutation causes temperature-dependent defects in mitochondrial inheritance, mitochondrial morphology, and the maintenance of mitochondrial DNA in the yeast Saccharomyces cerevisiae. Defects in mitochondrial transmission to daughter buds and changes in mitochondrial morphology were apparent within 30 min after shifting cells to 37 degrees C, while loss of the mitochondrial genome occurred after 4-24 h at the elevated temperature. The mdm17 lesion mapped to MGM1, a gene encoding a dynamin-like GTPase previously implicated in mitochondrial genome maintenance, and the cloned MGM1 gene complements all of the mdm17 mutant phenotypes. Cells with an mgm1-null mutation displayed aberrant mitochondrial inheritance and morphology. A version of mgm1 mutated in a conserved residue in the putative GTP-binding site was unable to complement any of the mutant defects. It also caused aberrant mitochondrial distribution and morphology when expressed at high levels in cells that also contained a wild-type copy of the gene. Mgm1p was localized to the mitochondrial outer membrane and fractionated as a component of a high molecular weight complex. These results indicate that Mgm1p is a mitochondrial inheritance and morphology component that functions on the mitochondrial surface. (+info)

... the use of fungal genomes in taxonomy is currently rare. Genome sequences can be used to expand the number of genes used in ... Fungal genomes are among the smallest genomes of eukaryotes. The sizes of fungal genomes range from less than 10 Mbp to ... The comparison of fungal genomes has been used to study the evolution of fungi, to improve the resolution of the phylogeny of ... The sizes and gene numbers of the smallest genomes of free-living fungi such as those of Wallemia ichthyophaga, Wallemia ...

https://en.wikipedia.org/wiki/Fungal_genome

2006's six-gene phylogeny) (CS1: long volume value, Articles with short description, Short description matches Wikidata, Fungal ... 2015) investigated the TEF1α gene, among a number of others, as potential genetic marker for fungal DNA barcoding. The TEF1α ... White TJ, Bruns T, Lee SJ, Taylor J (1990). "Amplification and direct sequencing of fungal ribosomal RNA genes for ... December 2015). "One fungus, which genes? Development and assessment of universal primers for potential secondary fungal DNA ...

https://en.wikipedia.org/wiki/Fungal_DNA_barcoding

Fungal Diversity. 65 (1): 77-88. doi:10.1007/s13225-013-0252-7. S2CID 15847954. G. S. de Hoog, Guarro J; Gene J; Figueras MJ ( ... When the fungal infection only concerns with systemic involvement except the brain, the probability of cure is higher. In ... Mazur, Joseph E. (1 February 2001). "A Case Report of a Dactylaria Fungal Infection in a Lung Transplant Patient. *. ". Chest. ... "Fungal Databases Nomenclature and Species Banks". International Mycological Association. BioloMICS Net. Retrieved 15 October ...

https://en.wikipedia.org/wiki/Ochroconis_gallopava

... s are common features of bacterial and most fungal genomes, and are less often found in other organisms. ... Metabolic gene clusters or biosynthetic gene clusters are tightly linked sets of mostly non-homologous genes participating in a ... Slot JC (2017). "Fungal Gene Cluster Diversity and Evolution". Advances in Genetics. 100: 141-178. doi:10.1016/bs.adgen.2017.09 ... Slot, Jason C.; Gluck-Thaler, Emile (2019-10-01). "Metabolic gene clusters, fungal diversity, and the generation of accessory ...

https://en.wikipedia.org/wiki/Metabolic_gene_cluster

A fungal past to insect color". Science. 328 (5978): 574-5. Bibcode:2010Sci...328..574F. doi:10.1126/science.1190417. PMID ... Citizendium:Horizontal gene transfer Citizendium:Horizontal gene transfer in prokaryotes Citizendium:Horizontal gene transfer ... The transferred gene (xenolog) found in the receiving species is more closely related to the genes of the donor species than ... HhMAN1 is a gene in the genome of the coffee berry borer (Hypothenemus hampei) that resembles bacterial genes, and is thought ...

https://en.wikipedia.org/wiki/Horizontal_gene_transfer

Corrêa TL, de Araújo EF (September 2020). "Fungal phytases: from genes to applications". Brazilian Journal of Microbiology. 51 ... "Directed evolution of thermostable kanamycin-resistance gene: a convenient selection marker for Thermus thermophilus". Journal ...

https://en.wikipedia.org/wiki/Thermostability

"Transcriptional Rewiring of Fungal Galactose-Metabolism Circuitry". Current Biology. 17 (12): 1007-1013. doi:10.1016/j.cub. ... They also use inputs such as trans and cis sequence regulators of genes, and outputs such as gene expression level. Depending ... These biological gene circuits can be used synthetically to act as physical models for studying regulatory function. By ... This rewiring is defined by the change in regulatory-target gene interactions, while there is still conservation of regulatory ...

https://en.wikipedia.org/wiki/Gene_regulatory_circuit

Fungal proteins, Saccharomyces cerevisiae genes, RNA splicing). ... The Prp8 gene encodes for a protein that is a central part of ... The Prp8 gene is located on chromosome VIII in yeast and chromosome 17 in humans. Pre-mRNA splicing involves two trans- ... Prp8 protein is coded by a single gene in humans with 42 exons. The size of Prp8 ranges between 230-280 kDa depending on the ... Prp8 refers to both the Prp8 protein and Prp8 gene. Prp8's name originates from its involvement in pre-mRNA processing. The ...

https://en.wikipedia.org/wiki/Prp8

Ghabrial SA (1998). "Origin, adaptation and evolutionary pathways of fungal viruses". Virus Genes. 16 (1): 119-31. doi:10.1023/ ... Some genes of RNA virus are important to the viral replication cycles and mutations are not tolerated. For example, the region ... After this DNA is integrated into the host genome using the viral enzyme integrase, expression of the encoded genes may lead to ... To date, the suggestions proposed have not been broadly accepted because of doubts over the suitability of a single gene to ...

https://en.wikipedia.org/wiki/RNA_virus

1992). "Fungal mating type genes - regulators of sexual development". Mycological Research. 96 (12): 993-1006. doi:10.1016/ ... Using elegant genetic and molecular techniques with different genetic stocks including gene deletions and gene fusions, she has ... A factors contain several duplicate genes coding for the A protein but it is only necessary for any one of these genes to be ... She was Professor Emeritus of Fungal Genetics in the Department of Plant Science at the University of Oxford, and was known for ...

https://en.wikipedia.org/wiki/Lorna_Casselton

Fungal plant pathogens and diseases, All stub articles, Capnodiales stubs, Fungal plant disease stubs). ... "Detailed information of Plant Disease - Large lady palm Brown leaf spot". www.gene.affrc.go.jp. Retrieved 2022-10-04. v t e v t ... Cercospora rhapidicola is a fungal plant pathogen. " ...

https://en.wikipedia.org/wiki/Cercospora_rhapidicola

"Decoding fungal genome: Salute to Dr Maqsudul Alam". Dhaka Courier. Archived from the original on 28 September 2014. Retrieved ... "Bangladeshi scientists invent fungus gene". New Age. 20 September 2012. Archived from the original on 13 November 2012. ... "BD scientists crack genome sequencing of fungal pathogen". The Financial Express. Dhaka. Retrieved 7 July 2013. " ...

https://en.wikipedia.org/wiki/Biotechnology_and_genetic_engineering_in_Bangladesh

Nishida, Hiromi; Yun, Choong-Soo (May 2011). "Extraction of tentative mobile introns in fungal histone genes". Mobile Genetic ... A majority of his work here centered around mitochondrial plasmid DNA found within fungal strains. Upon returning to St. Louis ...

https://en.wikipedia.org/wiki/Alan_Lambowitz

Turgeon, B.G.; Yoder, O.C. (2000). "Proposed Nomenclature for Mating Type Genes of Filamentous Ascomycetes". Fungal Genetics ... Outcrossing, through complementation, could provide the benefit of masking recessive deleterious mutations in genes which ... Mating type genes in ascomycetes are called idiomorphs rather than alleles due to the uncertainty of the origin by common ...

https://en.wikipedia.org/wiki/Mating_type

... gene rodA), these proteins are the main component of the hydrophobic sheath covering the surface of many fungal spores. Genomic ... a new Aspergillus developmental mutant induced by directed gene inactivation". Genes & Development. 5 (7): 1161-71. doi:10.1101 ... Nakari-Setälä T, Azeredo J, Henriques M, Oliveira R, Teixeira J, Linder M, Penttilä M (July 2002). "Expression of a fungal ... Wessels J, De Vries O, Asgeirsdottir SA, Schuren F (August 1991). "Hydrophobin Genes Involved in Formation of Aerial Hyphae and ...

https://en.wikipedia.org/wiki/Hydrophobin

Janson, Sven; Graneli, Edna (September 2003). "Genetic analysis of the psbA gene from single cells indicates a cryptomonad ... lichens are named and classified as fungal species. The association is termed a morphogenesis because the lichen has a form and ... The photobiont possibly triggers otherwise latent genes in the mycobiont. Trentepohlia is an example of a common green alga ... genes from Helicosporidium spp.: Evidence supporting the reclassification of Helicosporidia as green algae (Chlorophyta)". ...

https://en.wikipedia.org/wiki/Algae

Next-generation sequencing technologies generate large amounts of data, and analysis of fungal marker-gene data is an active ... fungal diversity in forest soils, stratification of fungal communities in soil horizons, and fungal succession on decomposing ... marker genes) to identify and describe the distribution of taxonomic groups in the fungal community in question, though more ... rapid taxonomic classification of fungal large-subunit rRNA genes". Applied and Environmental Microbiology. 78 (5): 1523-33. ...

https://en.wikipedia.org/wiki/Molecular_ecology

Protein pages needing a picture, Fungal proteins, Saccharomyces cerevisiae genes). ... Thus, the WHI1 gene was at first thought to perform a size control function analogous to that of Wee1 in pombe. However, it was ... The CLN3 gene was originally identified as the whi1-1 allele in a screen for small size mutants of Saccharomyces cerevisiae ( ... G1/S-specific cyclin Cln3 is a protein that is encoded by the CLN3 gene. The Cln3 protein is a budding yeast G1 cyclin that ...

https://en.wikipedia.org/wiki/Cln3

Protein pages needing a picture, Saccharomyces cerevisiae genes, Fungal proteins). ...

https://en.wikipedia.org/wiki/Pib2

The sexP gene is expressed during vegetative growth and matting while the sexM gene is expressed during mating. Glomeromycotina ... The fungal phylogeny". 21st Century Guidebook to Fungi (2nd ed.). Cambridge University Press. pp. 29-30. ISBN 978-1-108-74568-0 ... Lee SC, Idmurm A (2018). "8. Fungal sex: The Mucoromycota". In Heitman J, Howlett BJ, Crous PW, Stukenbrock EH, James TY, Gow ... Idnurm A, Walton FJ, Floyd A, Heitman J (January 2008). "Identification of the sex genes in an early diverged fungus". Nature. ...

https://en.wikipedia.org/wiki/Mucoromycota

"The Neurospora Compendium". Fungal Genetics Stock Center (FGSC). Retrieved December 27, 2005. "The Neurospora-Fungal Genome ... This led them to propose the "one gene, one enzyme" hypothesis that specific genes code for specific proteins. Their hypothesis ... The number of genes affecting the diploid stage was estimated to be at least 435 (about 4% of the total number of 9,730 genes ... This gene is necessary for the synthesis of pantothenic acid (vitamin B5), and mutants defective in this gene can be ...

https://en.wikipedia.org/wiki/Neurospora_crassa

"Application of Mating Type Gene Technology to Problems in Fungal Biology". Annual Review of Phytopathology. 36: 115-137. doi: ... The first mating pheromone-receptor genes characterized were for U. maydis. The A or b mating locus contains genes that code ... The results of these experiments led directly to the "one gene, one enzyme" hypothesis that specific genes code for specific ... The number of genes affecting the diploid stage was estimated to be at least 435 (about 4% of the total number of 9,730 genes ...

https://en.wikipedia.org/wiki/Mating_in_fungi

showed that the genes required for meiosis are present in T. marneffei, and that mating and genetic recombination occur in this ... O'Gorman CM, Fuller H, Dyer PS (January 2009). "Discovery of a sexual cycle in the opportunistic fungal pathogen Aspergillus ... Sexuality generates diversity in the aflatoxin gene cluster in A. flavus, suggesting that production of genetic variation may ... doi:10.1002/j.1537-2197.1947.tb13032.x. Nelson MA, Metzenberg RL (September 1992). "Sexual development genes of Neurospora ...

https://en.wikipedia.org/wiki/Heterothallism

Durrens P, Nikolski M, Sherman D (October 2008). "Fusion and fission of genes define a metric between fungal genomes". PLOS ... De novo gene birth ETV6-NTRK3 gene fusion Exon shuffling Gene duplication Horizontal gene transfer List of RNA-Seq ... Gene fusion plays a key role in the evolution of gene architecture. We can observe its effect if gene fusion occurs in coding ... A fusion gene is a hybrid gene formed from two previously independent genes. It can occur as a result of translocation, ...

https://en.wikipedia.org/wiki/Fusion_gene

Researchers are also attempting different gene disruption methods. With a better understanding of fungal gene regulation and ... Gene therapy is a technique that transplants normal genes into cells that contain missing or defective genes to correct genetic ... refers to the expression of a gene or part of a gene in a host organism that does not naturally have the gene or gene fragment ... Gene gun delivery/Biolistics has been an attractive method for gene delivery due to its non-viral properties, and in addition ...

https://en.wikipedia.org/wiki/Heterologous_expression

Amplification and direct sequencing of fungal ribosomal RNA genes for phylogenetics. PCR Protocols: a Guide to Methods and ... the 18S rRNA gene, the ITS1, the 5.8S rRNA gene, the ITS2, the 26S or 28S rRNA gene, and finally the 3' ETS. During rRNA ... It is not uncommon in bacteria to carry tRNA genes in the ITS. In eukaryotes, genes encoding ribosomal RNA and spacers occur in ... In bacteria and archaea, the ITS occurs in one to several copies, as do the flanking 16S and 23S genes. When there are multiple ...

https://en.wikipedia.org/wiki/Internal_transcribed_spacer

Taylor, D. J.; J. Bruenn (2009). "The evolution of novel fungal genes from non-retroviral RNA viruses". BMC Biology. 7: 88. doi ... Koonin, E. (2010). "Taming of the shrewd: novel eukaryotic genes from RNA viruses". BMC Biology. 8: 2. doi:10.1186/1741-7007-8- ...

https://en.wikipedia.org/wiki/Paleovirology

"Comparison of loline alkaloid gene clusters across fungal endophytes: predicting the co-regulatory sequence motifs and the ... of selected LOL genes by RNA interference and gene knockout have directly confirmed the involvement of two of the LOL genes in ... of at least eleven genes. The LOL genes are greatly and coordinately upregulated during loline alkaloid production, and ... These tests and similarities in the peptide sequences of the proteins encoded by these genes to known enzymes indicate that one ...

https://en.wikipedia.org/wiki/Loline_alkaloid

"The evolution of novel fungal genes from non-retroviral RNA viruses". BMC Biology. 7: 88. doi:10.1186/1741-7007-7-88. PMC ... Distinct, syncytin-like genes have been identified in primates, rodents, lagomorphs, carnivores, and ungulates, with ... Best S, Le Tissier P, Towers G, Stoye JP (August 1996). "Positional cloning of the mouse retrovirus restriction gene Fv1". ... Koonin EV (January 2010). "Taming of the shrewd: novel eukaryotic genes from RNA viruses". BMC Biology. 8: 2. doi:10.1186/1741- ...

https://en.wikipedia.org/wiki/Endogenous_viral_element

A multi-gene phylogenetic analysis of downy mildews". Fungal Genetics and Biology. 44 (2): 105-122. doi:10.1016/j.fgb.2006.07. ...

https://en.wikipedia.org/wiki/Peronosporaceae

... a human gene GalNAc-T1, a human gene Ribonuclease T1, a fungal endonuclease TNM staging system, classification for a small ...

https://en.wikipedia.org/wiki/T1

The kanamycin-resistance gene was used during the tomato's creation phase to help scientists identify plants with the genes ... The tomato has an improved shelf-life, increased fungal resistance and a slightly increased viscosity compared to its non- ... The Flavr Savr contains two genes added by Calgene; a reversed antisense polygalacturonase gene which inhibits the production ... The Flavr Savr also contained a kanamycin-resistance gene. This gene gave bacterial cells and chloroplasts resistance to ...

https://en.wikipedia.org/wiki/Flavr_Savr

... it serves as a model for studying regulation of the aflatoxin biosynthetic gene cluster (BGC). Sterigmatocystin was shown to be ... Fungal Genetics and Biology. 162: 103726. doi:10.1016/j.fgb.2022.103726. PMID 35843417. S2CID 250621883. "Sterigmatocystin". ...

https://en.wikipedia.org/wiki/Sterigmatocystin

An example for this is the deletion of recF, gene required for the function of recA, and its flanking genes. One of the ... Animal Genome Size Database Plant DNA C-values Database Fungal Genome Size Database Fungal Database Archived 2008-03-10 at the ... Evidence of the deletion of the function of repair and recombination is the loss of the gene recA, gene involved in the ... where the gene that have been lost are in fact not randomly dispersed in the ancestor gene but aggregated and the negative ...

https://en.wikipedia.org/wiki/Genome_size

Phylogenetic relationships of Sparassis inferred from nuclear and mitochondrial ribosomal DNA and a protein-coding gene (rpb2 ... Articles with 'species' microformats, Edible fungi, Taxa described in 1819, Fungi in cultivation, Polyporales, Fungal tree ... nuclear rDNA and rpb2 genes" (PDF). Mycologia. 98 (4): 584-92. doi:10.3852/mycologia.98.4.584. PMID 17139851. Blanco-Dios JB, ...

https://en.wikipedia.org/wiki/Sparassis

Gene cloning also confirmed that IFN-α was encoded by a family of many related genes. The type II IFN (IFN-γ) gene was also ... recent information demonstrates the importance of Type III IFNs in some types of virus or fungal infections. In general, type I ... elements in gene promoters. Type I IFNs can induce expression of genes with either ISRE or GAS elements, but gene induction by ... and vaccinia virus employs using the gene product of its E3L gene, p25. The ability of interferon to induce protein production ...

https://en.wikipedia.org/wiki/Interferon

"Global Characterization of Fungal Mitogenomes: New Insights on Genomic Diversity and Dynamism of Coding Genes and Accessory ... Endosymbiotic gene transfer, the process by which genes that were coded in the mitochondrial genome are transferred to the ... Adams KL, Palmer JD (December 2003). "Evolution of mitochondrial gene content: gene loss and transfer to the nucleus". ... Type 2, type 3 and type 5 mentioned in the plant and fungal genomes also exist in some protists, as do two unique genome types ...

https://en.wikipedia.org/wiki/Mitochondrial_DNA

Genes and Immunity. 14 (7): 420-6. doi:10.1038/gene.2013.34. PMC 3791179. PMID 23823019. Lien E, Ingalls RR (January 2002). " ... Several fungal ligands such as glucuronoxylomannan, phospholipomannan and zymosan have been reported. Moreover, TLR2/6 is known ... TLR6 human gene details in the UCSC Genome Browser. Overview of all the structural information available in the PDB for UniProt ... "Entrez Gene: TLR6 toll-like receptor 6". Oliveira-Nascimento L, Massari P, Wetzler LM (2012). "The Role of TLR2 in Infection ...

https://en.wikipedia.org/wiki/Toll-like_receptor_6

Deacon J. (2005). Fungal Biology. Cambridge, Massachusetts: Blackwell Publishers. pp. 262-3. ISBN 1-4051-3066-0. Morris MH, ... Worldwide Based on Multi-Gene Phylogeny, Morphology and Biogeography, and Insights on Amoenoboletus". Journal of Fungi. 8 (2): ... The characteristic feature of the mycorrhiza is the presence of a sheath of fungal tissue that encases the terminal, nutrient- ... Ortiz-Santana B, Lodge DJ, Baroni TJ, Both EE (2007). "Boletes from Belize and the Dominican Republic" (PDF). Fungal Diversity ...

https://en.wikipedia.org/wiki/Exsudoporus_frostii

Global fungal diseases > Preventing Deaths from Histoplasmosis. Untereiner, W.A.; Scott, J.A.; Naveau, F.A.; Bachewich, J. ( ... but a study of multiple genes suggests a recombining, sexual population. A recent analysis has suggested that the prevalent ... "Phylogeography of the fungal pathogen Histoplasma capsulatum". Molecular Ecology. 12 (12): 3383-401. doi:10.1046/j.1365-294x. ... dermatitidis and the South American pathogen Paracoccidioides brasiliensis in the recently recognized fungal family ...

https://en.wikipedia.org/wiki/Histoplasma_capsulatum

... a tumor suppressing gene, and at several guanine residues in the 12th and 13th codons of the ras gene, a gene whose product ... "Definition of Aspergillosis , Aspergillosis , Types of Fungal Diseases , Fungal Diseases , CDC". www.cdc.gov. Retrieved 2017-05 ... These effects seem to be largely mediated by mutations at guanine in codon 249 of the p53 gene, ... March 2004). "Clustered pathway genes in aflatoxin biosynthesis". Appl. Environ. Microbiol. 70 (3): 1253-62. Bibcode:2004ApEnM ...

https://en.wikipedia.org/wiki/Aflatoxin_B1

In general, the binding of pRb to E2F inhibits the E2F target gene expression of certain G1/S and S transition genes including ... In cells with nuclei (eukaryotes, i.e., animal, plant, fungal, and protist cells), the cell cycle is divided into two main ... Several gene expression studies in Saccharomyces cerevisiae have identified 800-1200 genes that change expression over the ... However, for reasons related to gene copy number effects, possession of extra copies of certain genes is also deleterious to ...

https://en.wikipedia.org/wiki/Cell_cycle

The majority of fungal biomass is found in the humus and litter layers of soil. Most truffle fungi produce both asexual spores ... ISBN 978-0-19-861186-8. Kohler, Annegre (2015). "Convergent losses of decay mechanisms and rapid turnover of symbiosis genes in ... Many ectomycorrhizal fungi form fungal mats in the upper layers of soils surrounding host plants. These mats have significantly ... "Tree genetics defines fungal partner communities that may confer drought tolerance". Proceedings of the National Academy of ...

https://en.wikipedia.org/wiki/Truffle

Ustilaginomycetes)". Fungal Diversity. 13: 167-173. Begerow, D., Göker, M., Lutz, M., Stoll, M. (2004). "On the evolution of ... In 2014 a new multiple gene sequence analysis showed that two additional classes, forming two independent deep lineages should ... "A phylogenetic hypothesis of Ustilaginomycotina based on multiple gene analyses and morphological data". Mycologia. 98 (6): 906 ...

https://en.wikipedia.org/wiki/Ustilaginomycotina

This method could be expanded to a wide array of genes in the entire family; as with native genes these are best deployed in ... Fungal plant pathogens and diseases, Soybean diseases, Pucciniales, Fungi described in 1914, Taxa named by Hans Sydow, Taxa ... and thus revealed that the number of ASR resistance genes in soybean germplasm is limited[16]. Resistance genes that provide ... natural resource can be used to identify additional resistance genes against ASR that are absent from the soybean gene pool." p ...

https://en.wikipedia.org/wiki/Phakopsora_pachyrhizi

... using a six-gene phylogeny including ribosomal DNA and protein-coding genes, found support for the establishment of a new class ... The fungi that are now included in the fungal class Geoglossomycetes were previously considered by mycologists to be a family ( ... Cannon PF, Kirk PM (2007). Fungal families of the world. Wallingford, UK: CAB International. ISBN 978-0-85199-827-5. (Articles ...

https://en.wikipedia.org/wiki/Geoglossaceae

Nakayama N, Miyajima A, Arai K (1985). "Nucleotide sequences of STE2 and STE3, cell type-specific sterile genes from ... Fungal pheromone mating factor receptors form a distinct family of G-protein-coupled receptors. Mating factor receptors STE2 ... structural properties deduced from the sequence of the STE2 gene". Nucleic Acids Res. 13 (23): 8463-8475. doi:10.1093/nar/13.23 ...

https://en.wikipedia.org/wiki/Fungal_mating_pheromone_receptors

One of the ways to overcome the survivability hurdle is to clone the genes encoding for the toxin into other organisms which ... Fungal Biology. 115 (8): 803-811. doi:10.1016/j.funbio.2011.06.006. ISSN 1878-6146. PMID 21802061. "Algatechnologies ... This subspecies produces a crystal composed of four main proteins encoded by four genes which are situated on a single plasmid ... One of the results of these researches is the development of a genetic engineering system for inserting genes into the genomes ...

https://en.wikipedia.org/wiki/Sammy_Boussiba

"Entrez Gene: MYD88 Myeloid differentiation primary response gene (88)". Bonnert TP, Garka KE, Parnet P, Sonoda G, Testa JR, ... "Drosophila MyD88 is required for the response to fungal and Gram-positive bacterial infections". Nature Immunology. 3 (1): 91-7 ... Genes on human chromosome 3, Immune system, Human proteins, Genes mutated in mice). ... The gene was originally discovered and cloned by Dan Liebermann and Barbara Hoffman in mice. In that species it is a universal ...

https://en.wikipedia.org/wiki/MYD88

... s disrupt the fungal plasma membrane, resulting in release of the intracellular content of the fungal cell. They also ... Therefore there are only two genes, HTN1 and HTN3. The N-terminus of Histatin 5 allows it to bind with metals, and this can ... other histatins are degradation products of Histatin 3 through the process of post-translational proteolysis of the HTN3 gene ...

https://en.wikipedia.org/wiki/Histatin

These include fungal (including lichen-forming species), invertebrate (particularly insect) and plant communities where the ... Biodiversity hotspots and coldspots are a way of recognizing that the spatial concentration of genes, species, and ecosystems ... With conservation management and planning for biodiversity at all levels, from genes to ecosystems, there are examples where ... ISBN 0-85403-617-2 Download "Orphans of Rio" (PDF). fungal-conservation.org. Retrieved 2011-07-09. Thomas, JA; Telfer, MG; Roy ...

https://en.wikipedia.org/wiki/Conservation_biology

Bennett, Joan W; Inamdar, Arati A (2015). "Are Some Fungal Volatile Organic Compounds (VOCs) Mycotoxins?". Toxins. Basel. 7 (9 ... ISBN 978-1-904455-44-8. Robinson, Samuel D; Norton, Raymond S (17 December 2014). "Conotoxin Gene Superfamilies". Marine Drugs ... such as fungal biotoxins, microbial toxins, plant biotoxins, or animal biotoxins. Toxins produced by microorganisms are ...

https://en.wikipedia.org/wiki/Toxin

Separate sets of CesA genes are involved in primary and secondary cell wall biosynthesis. There are known to be about seven ... "Fungal Cellulases". Chemical Reviews. 115 (3): 1308-1448. doi:10.1021/cr500351c. PMID 25629559. Mettler, Matthew S.; Vlachos, ... RTCs contain at least three different cellulose synthases, encoded by CesA (Ces is short for "cellulose synthase") genes, in an ... Bacterial cellulose is produced using the same family of proteins, although the gene is called BcsA for "bacterial cellulose ...

https://en.wikipedia.org/wiki/Cellulose

cubense Pronunciation (help·info) is a fungal plant pathogen that causes Panama disease of banana (Musa spp.), also known as ... Concordant evidence from nuclear and mitochondrial gene genealogies". Proceedings of the National Academy of Sciences. 95 (5): ... List of banana and plantain diseases Drenth, André; Guest, David I. (2016-08-04). "Fungal and Oomycete Diseases of Tropical ... Drenth, André; McTaggart, Alistair R.; Wingfield, Brenda D. (2019-10-29). "Fungal clones win the battle, but recombination wins ...

https://en.wikipedia.org/wiki/Fusarium_oxysporum_f.sp._cubense

NODs signal via N-terminal CARD domains to activate downstream gene induction events, and interact with microbial molecules by ... lipoproteins and fungal glucans and chitin. Endogenous stress signals are called damage-associated molecular patterns (DAMPs) ... December 1995). "A receptor kinase-like protein encoded by the rice disease resistance gene, Xa21". Science. 270 (5243): 1804- ... and single stranded RNA which recruit factors via twin N-terminal CARD domains to activate antiviral gene programs, which may ...

https://en.wikipedia.org/wiki/Pattern_recognition_receptor

... with approximately 12,000 genes being identifiable. Teleomorphs of Trichoderma are species of the ascomycete genus Hypocrea. ... Several strains of Trichoderma have been developed as biocontrol agents against fungal diseases of plants. The various ...

https://en.wikipedia.org/wiki/Trichoderma

The principal genes responsible for producing penicillin, pcbAB, pcbC, and penDE are closely linked, forming a cluster on ... Utrecht, the Netherlands: CBS-KNAW- Fungal Biodiversity Centre. pp. 1-398. Andersen B, Frisvad JC, Søndergaard I, Rasmussen IS ... Fierro F, Barredo JL, Díez B, Gutierrez S, Fernández FJ, Martín JF (June 1995). "The penicillin gene cluster is amplified in ... Matsuda Y, Awakawa T, Abe I (September 2013). "Reconstituted biosynthesis of fungal meroterpenoid andrastin A". Tetrahedron. 69 ...

https://en.wikipedia.org/wiki/Penicillium_chrysogenum

In late autumn, chemicals on the skin of the caterpillar interact with the fungal spores and release the fungal mycelia, which ... 2007). "A multi-gene phylogeny of Clavicipitaceae (Ascomycota, Fungi): identification of localized incongruence using a ... Gradually the host larvae become rigid because of the production of fungal sclerotia. Fungal sclerotia are multihyphal ... The stroma is the upper fungal part and is dark brown or black, but can be a yellow color when fresh, and longer than the ...

https://en.wikipedia.org/wiki/Ophiocordyceps_sinensis

Carotenes are further processed by carotene oxygenase, which is encoded in the tsp3 gene of the B. trispora, to produce TSA. ... Fungal Genetics and Biology. 44 (11): 1096-108. doi:10.1016/j.fgb.2007.07.008. PMID 17822929. Roukas T (2015). "The role of ... "Early and late trisporoids differentially regulate β-carotene production and gene transcript Levels in the mucoralean fungi ...

https://en.wikipedia.org/wiki/Blakeslea_trispora

Th1-type cell-mediated immunity (CMI) is required for clearance of a fungal infection. Candida albicans is a kind of diploid ... Fan W, Kraus PR, Boily MJ, Heitman J (2005). "Cryptococcus neoformans gene expression during murine macrophage infection". ... Brown GD, Drummond RA, Gaffen SL, Hise AG (2015). "Innate Defense against Fungal Pathogens". Cold Spring Harb Perspect Med. 5 ( ... A comprehensive comparison of distribution of opportunistic pathogens and stress-tolerant fungi in the fungal tree of life ...

https://en.wikipedia.org/wiki/Pathogenic_fungus

Target Genes, Primer Sets, and Thermocycler Settings for Fungal DNA Amplification. *Anamorph and Teleomorph Names for Candida ... Target Genes, Primer Sets, and Thermocycler Settings for Fungal DNA Amplification. ... This tool assumes that fungal DNA already exists; it does not describe the procedure for purification of fungal DNA. ... Development of primer sets designed for use with the PCR to amplify conserved genes from filamentous ascomycetes. Appl Environ ...

https://www.cdc.gov/fungal/lab-professionals/settings-for-fungal-dna-amplification.html

Fungal genetics Is the Subject Area "Fungal genetics" applicable to this article? Yes. No. ... Fungal genomics Is the Subject Area "Fungal genomics" applicable to this article? Yes. No. ...

https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2003583

Use of gene specific primers to identify fungal endophytes of native grasses. ... Use of gene specific primers to identify fungal endophytes of native grasses. ...

https://lternet.edu/biblio/use-of-gene-specific-primers-to-identify-fungal-endophytes-of-native-grasses/

In this study for the first time we have demonstrated that the promoter of the gene from rumen bacteria can express a fungal ... beta-glucanase gene and the celA gene. Using the transcriptional and protein localisation signals of the S. bovis \beta- ... glucanase gene, an in-frame tarnslational fusion between the end of the \beta-glucanase signal sequence and the ATG of the ... Neocallimastix patriciarum celA gene was constructed. The \beta-glucanase promoter-celA fusion was expressed in both E. coli ...

https://journals.tubitak.gov.tr/biology/vol25/iss1/4/

744 fungal, 524 protist and 1103 viral species in classroom dust. Actinobacteria (mean relative abundance 49.7%), ... and butyrate and propionate metabolic genes and pathways were significantly enriched in rural schools (p < 0.005), in line ... Fu, X., Ou, Z., Zhang, M. et al. Indoor bacterial, fungal and viral species and functional genes in urban and rural schools in ... Indoor bacterial, fungal and viral species and functional genes in urban and rural schools in Shanxi Province, China- ...

https://microbiomejournal.biomedcentral.com/articles/10.1186/s40168-021-01091-0

Differential expression in symbiosis of a repertoire of fungal and plant genes involved in the transport and metabolism of N ... Orchids are highly dependent on their mycorrhizal fungal partners for nutrient supply, especially during early developmental ... Fungal and plant gene expression in the Tulasnella calospora-Serapias vomeracea symbiosis provides clues about nitrogen ... Differential expression in symbiosis of a repertoire of fungal and plant genes involved in the transport and metabolism of N ...

https://escholarship.org/uc/item/6mn2c1s7

In P. chrysogenum, 748 genes showed differential expression, while 1572 genes from A. chrysogenum are differentially expressed ... including β-lactam biosynthesis genes. Most importantly, 35-57% of Velvet target genes are among those that showed differential ... Other genes not essential for β-lactam production are downregulated with a preference for those responsible for transport ... is that strain improvement programs in two unrelated fungal β-lactam antibiotic producers alter the expression of target genes ...

https://bmcgenomics.biomedcentral.com/articles/10.1186/s12864-017-3663-0

The qPCR assay was highly sensitive and did not amplify DNA from the other closely related fungal species and host plants. The ... The results showed considerable variation in the expression levels and timing of defense genes in both cultivars. ... Fungal Divers. 2012, 56, 131-144. [Google Scholar] [CrossRef]. *Raja, H.A.; Miller, A.N.; Pearce, C.J.; Oberlies, N.H. Fungal ... White, T.J.; Bruns, T.; Lee, S.; Taylor, J.W. Amplification and direct sequencing of fungal ribosomal RNA genes for ...

https://www.mdpi.com/2309-608X/8/2/149

Their distribution in fungal genes shows that different motifs are found in orthologous genes and similar motifs are found in ... Most of the genes in which megasatellites are found are of unknown function. In this work, we extended the search for ... to 20 additional completely sequenced fungal genomes and extracted 216 megasatellites in 203 out of 142,121 genes, ... Altogether, these results suggest that megasatellites are created and lost during evolution of fungal genomes, probably sharing ...

https://hal-pasteur.archives-ouvertes.fr/pasteur-01370689

Chickpea Defensin Gene Family: Promising Candidates for Resistance Against Soil‑Borne Chickpea Fungal Pathogens. Journal of ... Chickpea Defensin Gene Family: Promising Candidates for Resistance Against Soil‑Borne Chickpea Fungal Pathogens. A - Papers ... Genotype-specifc responses of several CaDEF and CaDEFL genes in fungal bioassays suggested their involvement in defense against ... uk/item/989y8/chickpea-defensin-gene-family-promising-candidates-for-resistance-against-soil-borne-chickpea-fungal-pathogens ...

https://repository.rothamsted.ac.uk/item/989y8/chickpea-defensin-gene-family-promising-candidates-for-resistance-against-soil-borne-chickpea-fungal-pathogens

Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. ... Stress-induced nuclear accumulation is dispensable for Hog1-dependent gene expression and virulence in a fungal pathogen. ...

https://abdn.pure.elsevier.com/en/publications/stress-induced-nuclear-accumulation-is-dispensable-for-hog1-depen/fingerprints/

We have identified five genes in Saccharomyces cerevisiae, YIL008w (URM1), YHR111w (UBA4), YOR251c (TUM1), YNL119w (NCS2) and ... Gene Deletion * Genes, Fungal * Genome, Fungal * Genomics * Mitochondrial Proteins * Molecular Sequence Data ...

https://pubmed.ncbi.nlm.nih.gov/19151091/

A new antibiotic and antifungal compound produced by a disease-causing bacteria in potatoes thwarts fungal infections in plants ... Gene-editing cockroaches with CRISPR-Cas9 - and maybe other insects. Core Sciences ... Solanimycin has been demonstrated to act against fungal disease in both plants and also on a common organism known as Candida ... "Its an antifungal that we believe that will work by killing fungal competitors, and the bacteria benefit so much from this," ...

https://cosmosmagazine.com/science/antibiotic-potato-fungal-infections/

Fungal Molecular Evolution: Gene Trees and Geologic Time. *M. Berbee, John W. Taylor ... using an approach involving multigene phylogenies and coalescent analyses of nine regions from five genes.. Expand. ...

https://www.semanticscholar.org/paper/Molecular-phylogeny-and-historical-biogeography-of-Jeandroz-Murat/13009085251cfea7c22fa30b4ca133e4d18f6d7e

All the latest science news about selfish genes from Phys.org ... Unravelling the genetics of fungal fratricide. Selfish genes ... Selfish genes can act as both makers, breakers of species. A selfish streak in genes known to drive species apart might ... How cells hack their own genes. DNA in all organisms from yeast to humans encodes the genes that make it possible to live and ... Our selfish genes contain the seeds of our destruction - but there might be a fix. The human race is in so much trouble that ...

https://phys.org/tags/selfish+genes/sort/liverank/all/

Bioinformatics Analysis of Upstream Region and Protein Structure of Fungal Phytase Gene. ... Bioinformatics Analysis of Upstream Region and Protein Structure of Fungal Phytase Gene. ... In this study, we sought to perform bioinformatics analysis of the upstream region and protein structure of fungal phytase to ... of the best pattern promoter resulting from the interaction between RNA polymerase and the promoter sequences of modified genes ...

http://olmdiagnostics.com/1970/01/01/bioinformatics-analysis-of-upstream-region-and-protein-structure-of-fungal-phytase-gene/

Terms: indoor air or indoor environment* or building air or ieq or iaq AND mold or molds or fungi or fungus or fungal 10 ... gene expression in several brain regions when compared to filtered air control, with the most consistent and pronounced ... Fungal infections; Fungi; Central nervous system; Indoor environments; Neurological reactions; Neurotransmitters; Brain ... Increasing evidence associates indoor fungal exposure with deleterious central nervous system (CNS) health, such as cognitive ...

http://www2a.cdc.gov/nioshtic-2/BuildQyr.asp?s1=%27indoor+air%27+or+%27indoor+environment%2A%27+or+%27building+air%27+or+ieq+or+iaq&f1=%2A&Startyear=&t1=0&s2=mold+or+molds+or+fungi+or+fungus+or+fungal+&B1=Search&terms=3&Adv=1&f2=%2A&Limit=500&Sort=DP+DESC&D1=10&EndYear=&PageNo=1&RecNo=10&View=f&

Frontiers Impact Metrics Powered by ...

http://loop-impact.frontiersin.org/impact/article/538641

showed the highest gene expression of Lcc under the same conditions of Lcc synthesis. The highest Lcc expression by the ... presented the highest Lcc activity (25.2 U·L−1). The effect of copper on Lcc gene expression was evaluated by reverse ... Molecular approaches allowed the detection of Lcc isozymes and suggest the presence of at least two undescribed putative genes ... Additionally, Lcc sequences from the both fungal strains clustered with other Lcc sequences from other fungi that inhabit ...

https://amb-express.springeropen.com/articles/10.1186/s13568-015-0106-7/tables/1

Epigenetic gene silencing by heterochromatin primes fungal resistance. Allshire, R. (Creator) & Torres Garcia, S. (Creator), ... Bresson, S. (Creator) & Tollervey, D. (Creator), National Center for Biotechnology Information (Gene Expression Omnibus), 8 Jun ... Draber, P. (Creator) & Stracquadanio, G. (Creator), National Center for Biotechnology Information (Gene Expression Omnibus), 12 ... Ivens, A. (Creator), National Center for Biotechnology Information (Gene Expression Omnibus), 10 Oct 2019 ...

https://www.research.ed.ac.uk/en/organisations/university-of-edinburgh/datasets/

Gene Wolfe on Shriek: An Afterword. "Fungal noir. Steampunk delirium. Paranoid spy thriller, quite literally, on shrooms." - ...

https://us.macmillan.com/books/9780374103170/%7B%7Bitem.url%7D%7D

Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces ... "Drug Resistance, Multiple, Fungal" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ... Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. Nature. 2016 Feb 25; 530(7591):485-9. ... This graph shows the total number of publications written about "Drug Resistance, Multiple, Fungal" by people in Harvard ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Drug%20Resistance,%20Multiple,%20Fungal

Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001 Oct ... This may include systemic fungal infections and chronic infection with Cryptosporidium parvum, which can be particularly ... The X-linked form of the disease, type 1, is caused by mutations in the gene encoding the CD40 ligand. CD40 ligand is a ... The major form of X-HIM syndrome results from mutations in the gene encoding for CD40L (CD154). The image below is a schematic ...

https://www.medscape.com/answers/136897-121048/what-is-the-role-of-smoking-in-the-etiology-of-immunoglobulin-g-igg-deficiency

... along with polymorphisms of their genes and their prognostic values in breast cancer. The following clinical and pathological ... Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Fungal Pathogens During ... Editorial: The World Health Organization (WHO) Fungal Priority Pathogens List in Response to Emerging Funga... Med Sci Monit ... Association between polymorphisms of XRCC1, p53 and MDR1 genes, the expression of their protein products and prognostic ...

https://medscimonit.com/abstract/metrics/idArt/882121

The bacterium can complement the host enzymatic capabilities, alter the fungal metabolism, cell membrane composition but does ... The bacterial and fungal reads were assembled separately.. Gene Calling. MAKER (v.2.31.8) (Campbell et al., 2014) was used as ... As part of MAKER, AUGUSTUS (3.3) (Hoff and Stanke, 2013), and GeneMark-ES fungal version (v.4.21) were used as ab initio gene ... Genome completeness was verified using single copy fungal orthologous genes searched by BUSCO (Simão et al., 2015). Only a few ...

https://www.frontiersin.org/articles/10.3389/fmicb.2021.636986/full

Novel genes involved in secondary metabolism, including genes implicated in ophiobolin biosynthesis, were identified. Among 37 ... Additionally, a finished mitochondrial genome sequence of 135,790 bp was obtained, which contained 75 predicted genes. ... B. cookei genes induced during sorghum infection, one encodes a putative effector with a limited taxonomic distribution among ... 2). A total of 75 mitochondrial genes were predicted, including 12 of 14 highly conserved genes among fungal mitochondria: four ...

https://www.nature.com/articles/s41598-017-17476-x?error=cookies_not_supported&code=ff9b875d-ec58-47c7-a554-6b2410e5ca8f

For this reason, I am developing a set of molecular tools that will allow us to engineer these fungal genomes and, ultimately, ... Analysis of their genomes show a wealth of biosynthetic gene clusters (BGCs) that indicate their ability to create a large ... As shown in the image below, fungal natural products represent a multi-billion-dollar industry that dates back to the early ... However, at this time, we lack the tools to manipulate these genes and validate their activity. ...

https://www.purdue.edu/gradschool/pulse/profiles/hillman.html

White, T. J., Bruns, T., Lee, S., & Taylor, J. (1990). Amplification and direct sequencing of fungal ribosomal RNA genes for ... 2009). Fungal diversity in ancient documents. A case study on the Archive of the University of Coimbra. International ... The dominant fungal aerosol fractions had aerodynamic diameters that ranged between 1.1 and 2.1 µm in museum storerooms. We ... Percentage contribution of each size fraction (aerodynamic diameter I-VI) of fungal bioaerosol. a Warehouse 2 in Museum II; b ...

https://link.springer.com/article/10.1007/s10453-015-9372-8

The filamentous fungal gene expression database (FFGED) Article Title:. Fungal genetics and biology : FG & B.. Author:. Zhang, ...

https://openagricola.nal.usda.gov/?author=&f%5Bformat%5D%5B%5D=Electronic&f%5Btopic_facet%5D%5B%5D=databases&op=AND&per_page=50&search_field=advanced&sort=relevance&title=&topic=

Eduard Akhunov, associate professor of plant pathology at Kansas State University, and his colleague, Jorge Dubcovsky from the University of California-Davis, led a research project that identified a gene that gives wheat plants resistance to one of the most deadly races of the wheat stem rust pathogen -- called Ug99 -- that was first discovered in Uganda in 1999. (farms.com)
Wheat stem rust is caused by a fungal pathogen. (farms.com)
Today, I'm going to be talking in some detail about the interaction between C. elegans and a specific fungal pathogen. (hstalks.com)
During fungal infection the host plant recognizes pathogen effectors, which trigger a host defense response. (globalrust.org)
Rust is a biotrophic fungal disease, by which is meant that the pathogen utilizes enzyme strategies to penetrate the leaf cell to access nutrients. (groworganicapples.com)
Here I studied the control of the isoprenoid pathway during plant-pathogen interactions using tobacco and its fungal pathogen Phytophthora. (tamu.edu)
A native fungal pathogen, Septoria musiva, has begun moving west, attacking natural populations of black cottonwood in Pacific Northwest forests and intensively cultivated hybrid poplar in Ontario. (ien.com)
Other submissions received in 2014 include a critically endangered Hawaiian crow ( Corvus hawaiienis ), famine-causing ascomycete fungal pathogen ( Cercospora zeina ), and hermaphroditic fish ( Kryptolebias marmoratus ). (pacb.com)

Fungal biofilm-associated infections are frequently refractory to conventional therapy because of resistance to antimicrobial agents. (cdc.gov)
The use of drugs effective in combating biofilm-associated infections could lead to major developments in the treatment of fungal implant infections. (cdc.gov)
Solanimycin has been demonstrated to act against fungal disease in both plants and also on a common organism known as Candida albicans , which is present inside the body naturally, but can become out of control and cause dangerous infections. (cosmosmagazine.com)
Worldwide, millions of people suffer debilitating and even fatal fungal infections. (sciencenews.org)
The resulting immune system abnormalities make people with AD-HIES highly susceptible to infections, particularly bacterial and fungal infections of the lungs and skin. (medlineplus.gov)
Drug-resistant fungal infections are a growing problem. (irbbarcelona.org)
Fungal nail infections, also known as "onychomycosis," are very common. (cdc.gov)
Fungal toenail infections are more common than fungal fingernail infections. (cdc.gov)
Most fungal nail infections are not serious. (cdc.gov)
People who have fungal toenail infections often have a fungal skin infection on the foot, especially between the toes (commonly called athlete's foot , ringworm on the foot, or tinea pedis). (cdc.gov)
Fungal nail infections are caused by many different types of fungi that live in the environment. (cdc.gov)
Who gets fungal nail infections? (cdc.gov)
Fungal infections are not the only possible cause of nail problems. (cdc.gov)
Other conditions can look similar to fungal nail infections. (cdc.gov)
Fungal nail infections can be difficult to cure, and treatment is most successful when started early. (cdc.gov)
Fungal nail infections typically don't go away on their own, and the best treatment is usually prescription antifungal pills taken by mouth. (cdc.gov)
Fungal nail infections can be closely associated with fungal skin infections. (cdc.gov)
Patients should discuss all skin concerns with their healthcare provider to ensure that all fungal infections are properly treated. (cdc.gov)
Even after treatment, fungal nail infections can come back. (cdc.gov)
Molecular testing, including polymerase chain reaction (PCR) testing, may be used to diagnose fungal nail infections. (cdc.gov)
In fact, thousands of deaths can be traced every year to fungal infections around medical implants. (mit.edu)
The finding might offer a new way to prevent or treat certain yeast and fungal infections, and the researchers' work also provides an unexpected new role for some proteins already known to help hungry yeast live longer. (news-medical.net)
Other researchers have reported that the EPA genes also help C. glabrata stick to plastic, which might explain the organism's propensity to cause catheter infections. (news-medical.net)
Studies suggest that fluconazole prophylaxis may help to prevent invasive fungal infections, including endocarditis, in the newborn population. (medscape.com)
DOC for severe fungal infections. (medscape.com)
Adjunct to amphotericin B that seems to have a synergistic therapeutic effect in severe fungal infections. (medscape.com)
The cause opportunistic invasive fungal infections. (cdc.gov)
Prior to studies of and broad institution of antifungal prophylaxis in high-risk preterm infants, the incidence of fungal infections had been rising in infants born at less than 1000 g, with the ensuing resuscitation and survival of more and more infants. (medscape.com)
For these reasons, fungal infections are often difficult to eradicate in the preterm infant and, in cases of candidemia, central venous catheter removal is critical for clearance and survival. (medscape.com)
Although these immunocompromised infants are at increased risk during most of their hospital stay, they are at the highest risk of acquiring invasive fungal infections during the first weeks of life, when the most invasive therapies are performed and remain in place. (medscape.com)
The pathogenesis of fungal infections in preterm infants involves adherence, colonization, and dissemination (as shown in the image below). (medscape.com)
Pathogenesis and invasive fungal infections in very low birth weight infants. (medscape.com)
This leads to recurring bacterial and fungal infections that respond poorly to antibiotics, require frequent hospitalizations, and can be fatal. (ca.gov)
Background: Coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome patients are at risk for fungal infections, especially aspergillosis and mucormycosis. (bvsalud.org)
Some fungal diseases like fungal meningitis and bloodstream infections are less common than skin and lung infections but can be deadly. (cdc.gov)

Detection and characterization of megasatellites in orthologous and nonorthologous genes of 21 fungal genomes. (archives-ouvertes.fr)
In this work, we extended the search for megasatellites to 20 additional completely sequenced fungal genomes and extracted 216 megasatellites in 203 out of 142,121 genes, corresponding to the most exhaustive description of such genetic elements available today. (archives-ouvertes.fr)
Altogether, these results suggest that megasatellites are created and lost during evolution of fungal genomes, probably sharing similar functions, although their primary sequences are not necessarily conserved. (archives-ouvertes.fr)
Analysis of fungal genomes reveals commonalities of intron gain or loss and functions in intron-poor species. (otago.ac.nz)
Analysis of their genomes show a wealth of biosynthetic gene clusters (BGCs) that indicate their ability to create a large variety of compounds that are synthesized in ways similar to antibiotics. (purdue.edu)
For this reason, I am developing a set of molecular tools that will allow us to engineer these fungal genomes and, ultimately, these synthetic biology tools will allow us to control the expression of the BGCs for antibiotic and pharmaceutical purposes. (purdue.edu)
Only one of these sequences showed similarity to known genes in the databases: it was a homolog of 100-105 kDa transcriptional co-activator proteins in the rat, human and Caenorhabditis elegans genomes. (biomedcentral.com)
When analyzing the polyketide gene clusters from the sequenced dermatophyte genomes 1 , 8 , we found an orthologous gene cluster, which is also conserved in pathogenic fungi Aspergillus fumigatus and Neosartorya fischeri 10 , 11 ( Figure 1 ). (cdc.gov)
In addition to these four well-conserved "core PKS genes", the neighboring regions encode additional genes, some of which are highly syntenic and conserved between genomes ( Figure 1 ). (cdc.gov)
In order to allow comparative analyses with other fungal genomes sequenced by the JGI, a copy of this genome is incorporated into Mycocosm. (doe.gov)
A fungal phylogeny based on 42 complete genomes derived from supertree and combined gene analysis. (uniba.sk)
Combining the understanding of biosynthetic gene clusters (BGCs) and improved ability to edit streptomycete genomes, combinatorial engineering of analogue libraries for the purpose of producing a final therapeutically relevant product can now be accomplished at a faster pace. (biomedcentral.com)

This document describes some of the target genes and primers that can be used for DNA sequence-based identification of fungi and the PCR conditions with which to use those primers. (cdc.gov)
To address the question whether both fungi have undergone similar genetic adaptions, we have performed a comparative gene expression analysis of wild-type and production strains. (biomedcentral.com)
Common in both fungi is the upregulation of genes belonging to primary and secondary metabolism, notably those involved in precursor supply for β-lactam production. (biomedcentral.com)
pcbAB and pcbC, the genes coding for the first two enzymes involved in β-lactam biosynthesis, are genomically clustered in both bacteria and fungi. (biomedcentral.com)
This clustered organization and the lack of intronic sequences in most of the genes led to the assumption that bacterial β-lactam antibiotic genes were transferred horizontally from bacteria to fungi [ 5 ]. (biomedcentral.com)
Among 37 B. cookei genes induced during sorghum infection, one encodes a putative effector with a limited taxonomic distribution among plant pathogenic fungi. (nature.com)
Gene structure, including the transcript leader, is very diverse in fungi. (pasteur.fr)
Fungal culture can be used to identify the infecting organism, but the fungi may take several weeks to grow. (cdc.gov)
Now, researchers at the Whitehead Institute for Biomedical Research have found a key gene that allows fungi to stick to plastic surfaces and form thin coatings called biofilms. (mit.edu)
Scientists were excited about this finding because they knew that FLO11 belongs to a large family of genes present in many pathogenic fungi. (mit.edu)
Sophisticated molecular biological research has revealed many virulence attributes in at least four pathogenic fungi, but the future study of fungal virulence requires investigators to distinguish between molecules that directly interact with the host, molecules that regulate these, and molecules that are always required for fungal growth and survival, independent of the host. (biomedcentral.com)
Almost all of the fungi that cause fatal diseases gain access to the host via the lungs by inhalation of spores, yet Candida species, which account for a high morbidity and mortality in individuals with reduced numbers of neutrophils, become pathogenic only when lowered host defences allow the fungal cells to pass from the gut into the bloodstream. (biomedcentral.com)
Unfortunately, under laboratory conditions many of the gene clusters in fungi are silent and hence mask the products encoded in them 9 . (cdc.gov)
90% identity between them) ( Table S3, Supplementary Information ), and the lower sequence homology to those in A. fumigatus and N. fischeri (~70% identity, Table S3 ), raise an interesting question as to whether these fungi produce similar compounds, and whether the presence of additional conserved genes may lead to further tailoring of the neosartoricin scaffold. (cdc.gov)
In addition, introduction of C albicans strains with two functional copies of the INT1 gene increased the number of fungi colonizing the cecum and disseminating to extraintestinal sites. (medscape.com)
A novel toxicity bioassay utilizing eukaryotic cells has been developed based on filamentous fungi transformed with the recombinant aequorin gene. (biomedcentral.com)
However, very little work in this area has been done on filamentous fungi due to the lack of both routine and reliable methods for monitoring intracellular free Ca 2+ in living fungal cells. (biomedcentral.com)
The reviewers praised the multi-gene approach used by Balajee and her infectious-disease colleagues, predicting that the method will lead to a sharp increase in the identification of new fungi in the future. (fredhutch.org)

Metagenomic profiling revealed 8302 bacterial, 395 archaeal, 744 fungal, 524 protist and 1103 viral species in classroom dust. (biomedcentral.com)
A selfish streak in genes known to drive species apart might occasionally bring them closer together, says a new study from the University of Nebraska-Lincoln and University of Rochester. (phys.org)
This study analyzed the genetic structure of truffles assigned to either of the two putative species from a geographically broad sampling across Europe, using an approach involving multigene phylogenies and coalescent analyses of nine regions from five genes. (semanticscholar.org)
They first measured the activity levels of enzymes secreted by the three fungal species during fermentation of bagasse, pure cellulose and sugarcane glucose. (eurekalert.org)
Through the use of bioinformatics tools, they compared the data and were able to pinpoint gene networks that are co-regulated by the three fungal species and could be essential for biomass breakdown by these microorganisms. (eurekalert.org)
We identified highly synergistic gene co-regulation networks involved in enzymatic degradation of sugarcane biomass by the three fungal species," said Jaire Alves Ferreira Filho, who is studying for a PhD in genetics and molecular biology at UNICAMP and is one of the authors of the FAPESP-funded study. (eurekalert.org)
The researchers identified 80 proteins and their respective genes shared by the three fungal species. (eurekalert.org)
They found 19 of these proteins in all three fungal species. (eurekalert.org)
Gene expression must be carefully regulated in all species. (otago.ac.nz)
Scientists led by Dr. Toni Gabaldón , ICREA researcher and group leader at the Institute for Research in Biomedicine (IRB Barcelona) and the Barcelona Supercomputing Center (BSC), have studied the resistance mechanisms developed by the species Candida glabrata upon exposure to various drugs and have identified eight genes that, when mutated, are responsible for allowing the fungus to adapt and survive treatment. (irbbarcelona.org)
Pathogenic fungal species differ in their cell morphologies: most exist as filamentous moulds (with hyphae) in the environment, but the most virulent among them often change to a unicellular (yeast or spherule) form when they invade tissues. (biomedcentral.com)
The diversity of pathogenic potency, cellular form and route of invasion between fungal species makes it impossible to draw general conclusions about their molecular virulence attributes. (biomedcentral.com)
It also provide molecular-based, PCR-less identification of bacterial/viral/fungal and species-specific genes. (openpr.com)
Most individual indicator fungal species were lower with asthma and wheeze and higher with aeroallergen positivity and rhinitis, whereas bacterial data was less consistent. (cdc.gov)
Health outcomes might be more influenced by the composition of a complex mixture of bacterial and fungal species in the indoor environment than by the absence or presence of individual species. (cdc.gov)
Eleven strains of well known bacterial and fungal species with four different isotopically define carbon sources were grown and their isotope ratios of fatty acids of different lipid fractions were identified. (readabstracts.com)
Through genetic engineering, for example, researchers could insert genes, from a similar or unrelated species, that help a tree tolerate or fight an insect or fungus. (ien.com)
Instead, the detection of a new fungal species began with Molly Weaver's furrowed brow and a sense that something was amiss. (fredhutch.org)
A long and exhaustive investigation of the mold's genes by Balajee and Marr, with technical support from Jennifer Gribskov and University of Washington computational biologist Dr. David Nickle, proved the lab had uncovered a new species - Aspergillus lentulus. (fredhutch.org)

Genotype-specifc responses of several CaDEF and CaDEFL genes in fungal bioassays suggested their involvement in defense against fungal pathogens such as hemi-biotrophic F. oxysporum f. sp. (rothamsted.ac.uk)
New sequencing data analysis from the RNA Biology of Fungal Pathogens unit revealed. (pasteur.fr)
In the case of opportunistic fungal pathogens, an understanding of host immune dysfunction is as important as an appreciation of which fungal genes may encode definable attributes of virulence. (biomedcentral.com)
But the rapid progress made in identifying molecular virulence factors in several fungal pathogens has also raised some caveats and paradoxes that require resolution. (biomedcentral.com)
capsulatum is a dimorphic fungus whose conidia (spores) are inhaled, germinate in the lungs and convert to a budding yeast form that, uniquely among fungal pathogens, becomes an intracellular parasite that is ingested by pulmonary macrophages but survives and multiplies within phagolysosomes. (biomedcentral.com)
Environmental maternal effects on the resistance of Eucalyptus grandis to pathogens and the structuring of fungal endophytic communities. (up.ac.za)

Megasatellites are large DNA tandem repeats, originally described in Candida glabrata, in protein-coding genes. (archives-ouvertes.fr)
Writing in the March 18 issue of Science , the researchers report that the yeast Candida glabrata use a family of proteins called sirtuins to block access to genes that would otherwise help the yeast stick. (news-medical.net)
$106,019 detection for fungal diseases, like Candida auris , means patients receive appropriate treatment and while reducing unnecessary antibiotic use. (cdc.gov)

We report a lung-invasive fungal disease with possible cutaneous needle tract seeding in a patient with a febrile neutropenia caused by the Basidiomycetes mold Inonotus spp. (cdc.gov)
should be added to the list of microorganisms causing invasive fungal disease in neutropenic patients with hematologic malignancies. (cdc.gov)
Computed tomography of the lungs in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)
Skin lesion at biopsy site 4 weeks after the biopsy in patient with invasive fungal disease caused by Inonotus spp. (cdc.gov)

Perception of the high incidence of fungal diseases, particularly those that threaten life, has led to considerable investment in research into fungal virulence, often based on cutting-edge molecular biological approaches. (biomedcentral.com)

The 19 proteins and their respective genes are involved in the production and secretion of hydrolytic enzymes and are associated with different fungal mechanisms of biomass breakdown, the researchers explained. (eurekalert.org)
Now that the resistance gene has been found, Akhunov and colleagues are looking at what proteins are transferred by the fungus into the wheat plants and recognized by the protein encoded by the Sr35 gene. (farms.com)
But urine has only tiny amounts of niacin, so the sirtuins don't work, the genes are exposed, and the yeast can make the proteins that help it stick to cells in the urinary tract, the researchers discovered. (news-medical.net)
Among other things, Sir3 and specific other proteins attach themselves near the tips of chromosomes, obscuring the nearby genes," says Cormack. (news-medical.net)
In the new work, graduate student Renee Domergue studied C. glabrata she had engineered to become permanently drug-resistant if the adhesion-promoting genes got turned on, which would only happen if Sir3 and the other proteins had stopped covering them up for some reason. (news-medical.net)
Fungal srs2 proteins, an ATP-dependent DNA helicase involved in DNA repair. (embl.de)

A mixed infection of helenium virus S with two distinct isolates of butterbur mosaic virus, one of which has a major deletion in an essential gene. (usda.gov)
The interesting thing about this work is that the identification of these eight genes allows us to use a genetic test to diagnose potential drug resistance present in the infection of a specific patient and, therefore, help choose the best treatment," says Dr. Gabaldón , head of the Comparative Genomics lab at IRB Barcelona. (irbbarcelona.org)
How does someone get a fungal nail infection? (cdc.gov)
Anyone can get a fungal nail infection. (cdc.gov)
Occasionally, a bacterial infection can occur on top of a fungal nail infection and cause serious illness. (cdc.gov)
If a fungal infection is not treated, it can spread from one place to the other. (cdc.gov)
This is more common in people who have conditions like diabetes that make them more likely to get a fungal nail infection. (cdc.gov)
Examination of nail clippings with a PAS stain can confirm the diagnosis of a fungal nail infection. (cdc.gov)
A fungal infection can lead to complications for contact lens wearers and, more seriously, patients with hip replacements. (mit.edu)
The objectives of this study are to identify and characterize wheat genes that are utilized by races differently throughout infection and to understand functions of these genes using gene silencing. (globalrust.org)
RNAi was used to silence seven wheat genes to further understand their roles in leaf rust infection. (globalrust.org)
All of these factors place them at high risk for fungal infection. (medscape.com)
The authors also state that without night ventilation, plant cells can be damaged by root pressure (water turgor) building up, creating sites for possible fungal infection. (greenhousemag.com)

It is speculated that they may respond to multiple fungal signals, and play an important role in potato's broad-spectrum resistance to fungal diseases, and can be used as candidate genes for further needed on disease resistance and functional analysis. (chinacrops.org)
With funding for fungal disease surveillance, Connecticut increased their ability to identify fungal diseases, monitor for new and emerging resistance, and implement strategies to prevent its spread in high-risk areas. (cdc.gov)
We think that mRNA would provide an excellent platform against viral, bacterial and fungal diseases," he says. (nextbigfuture.com)
Fungal diseases can affect anyone. (cdc.gov)
Mild fungal skin diseases can look like a rash and are very common. (cdc.gov)
Fungal diseases in the lungs are often similar to other illnesses such as bacterial or viral pneumonia. (cdc.gov)

However, the levels of therapeutic gene expression is consistantly controlled by insertion promoter of viral vector. (ca.gov)

We identified 567 P. chrysogenum and 412 A. chrysogenum Velvet target genes. (biomedcentral.com)
Most importantly, 35-57% of Velvet target genes are among those that showed differential expression in both improved industrial strains. (biomedcentral.com)
The major finding of our comparative transcriptome analysis is that strain improvement programs in two unrelated fungal β-lactam antibiotic producers alter the expression of target genes of Velvet, a global regulator of secondary metabolism. (biomedcentral.com)
Genome-wide expression profiling, in vivo DNA binding analysis, and probabilistic motif prediction reveal novel Abf1 target genes during fermentation, respiration, and sporulation in yeast. (yeastgenome.org)
Microarrays of secondary metabolite biosynthetic genes of Aspergillus nidulans are used to identify target genes of the fungus being up- or downregulated when interacting with the antagonistic Drosophila larvae. (marinefungi.eu)

DNA in all organisms from yeast to humans encodes the genes that make it possible to live and reproduce. (phys.org)
In this study, the researchers found that baker's yeast (Saccharomyces cerevisiae) adhered to plastic plates, suggesting that like their infectious fungal cousins, yeast, too, can form biofilms. (mit.edu)
He then found that the same gene also allowed yeast to stick to hard plastic surfaces. (mit.edu)
Then, in 2003, postdoctoral fellows Alejandro De Las Peñas and Irene Castaño discovered that yeast missing the gene for Sir3 were super-sticky. (news-medical.net)
In yeast missing Sir3, the EPA genes were exposed and used. (news-medical.net)
The researchers' latest work demonstrates that environmental influences -- not just the engineered loss of a gene -- can dictate whether the yeast can use these EPA genes. (news-medical.net)
Turning to laboratory dishes again, Domergue discovered that the yeast rapidly became drug-resistant (indicating the adhesion-promoting genes had been turned on) when they were grown in artificial urine -- a mix of specific chemicals in known amounts. (news-medical.net)
Without niacin, these yeast can't make NAD+, and so the sirtuins don't block access to the EPA genes, the researchers report. (news-medical.net)
Using a recombination-based cloning strategy in yeast, we constructed fungal heterologous expression vectors that encode the cryptic clusters. (cdc.gov)
To examine the activities of the conserved core PKS genes from dermatophytes, we cloned the clusters using yeast recombination 12 followed by expression in Aspergillus nidulans ( Figure S1, Supplementary Information ). (cdc.gov)
The tree versus the forest: the fungal tree of life and the topological diversity within the yeast phylome. (uniba.sk)
The absence of a functional INT1 gene diminishes adherence in yeast cells but not filamentous forms. (medscape.com)
Compared with glucose-limited condition, under Pi-limited aerobic condition, the budding yeast S. cerevisiae up-regulated 292 genes and activated a regulatory mechanism known as the PHO pathway, leading to an increased expression of multiple genes involved in Pi acquisition and uptake [ 16 ]. (biomedcentral.com)

Change in Gibbs free energy (ΔG) of the best pattern promoter resulting from the interaction between RNA polymerase and the promoter sequences of modified genes of phytase was equal to -9 kcalmol-1, which is lower compared to other interactions. (olmdiagnostics.com)
The recent availability of large amounts of sequence data, particularly complete genome sequences and transcriptomes and proteomes, has revolutionised the study of gene expression. (otago.ac.nz)
And as the gene sequences of the chitinases were known, they were further classified into six classes based on their sequences. (wikipedia.org)
The laboratory also was involved in analysis and annotation of fungal genome sequences. (marinefungi.eu)

Fungal and plant gene expression in the Tulasnella calospora-Serapias vomeracea symbiosis provides clues about nitrogen pathways in orchid mycorrhizas. (escholarship.org)
Differential expression in symbiosis of a repertoire of fungal and plant genes involved in the transport and metabolism of N compounds suggested that organic N may be the main form transferred to the orchid host and that ammonium is taken up by the intracellular fungus from the apoplatic symbiotic interface. (escholarship.org)
It is so far unknown, whether equivalent changes in gene expression lead to elevated antibiotic titers in production strains. (biomedcentral.com)
In P. chrysogenum , 748 genes showed differential expression, while 1572 genes from A. chrysogenum are differentially expressed in the industrial strain. (biomedcentral.com)
Analysis of cortex, midbrain, olfactory bulb, and cerebellum tissue from mice exposed to viable A. versicolor spores for 1, 2, and 4 weeks revealed significantly elevated pro-inflammatory (Tnf and Il1b) and glial activity (Gdnf and Cxc3r1) gene expression in several brain regions when compared to filtered air control, with the most consistent and pronounced neuroimmune response 48H following the 4-week exposure in the midbrain and frontal lobe. (cdc.gov)
Upregulation of Drd1, Penk, and Pdyn mRNA expression was confirmed in the 4-week A. versicolor exposed midbrain tissue, highlighting that gene expression important for neurotransmission was affected by repeated A. versicolor inhalation exposure. (cdc.gov)
Taken together, these findings indicate that the brain can detect and respond to A. versicolor inhalation exposure with changes in neuroimmune and neurotransmission gene expression, providing much needed insight into how inhaled fungal exposures can affect CNS responses and regulate neuroimmune homeostasis. (cdc.gov)
In this study, we sought to perform bioinformatics analysis of the upstream region and protein structure of fungal phytase to improve its expression and thermostability properties. (olmdiagnostics.com)
Induction, expression and characterisation of laccase genes from the marine-derived fungal strains Nigrospora sp. (springeropen.com)
Differential roles of transcriptional mediator subunits in regulation of multidrug resistance gene expression in Saccharomyces cerevisiae. (harvard.edu)
Artemio Mendoza (Bio-Protection, Lincoln) Genomics of fungal-plant interactions - Gene expression bioinformatics. (otago.ac.nz)
Changes in gene expression, by application of H2O2, O2(o-) generating agents (methyl viologen, digitonin) and gamma irradiation to tomato suspension cultures, were investigated and compared to the well-described heat shock response. (usda.gov)
Expression is mediated by the NPR1 gene and the salicylic acid pathway, both involved in resistance to fungal and insect attack. (wikipedia.org)
RNA was sequenced and 63 wheat genes were identified that showed varying expression in response to the six races. (globalrust.org)
Majority of the candidate genes showed three main expression patterns. (globalrust.org)
However, race specific expression was found in three wheat genes that are affected by race shifts on Lr2A, Lr2C, and Lr17A. (globalrust.org)
The present review focuses on recent advances in fungal chitinases, containing a short introduction to types of chitinases, their fermentative production, purification and characterization and molecular cloning and expression. (who.int)
After inoculating Phytophthora infestans ( Pi ) and Fusarium sulphureum ( Fs ), eight and six StCRK s gene differentially expressed, among them, StCRK 4 and StCRK 8 had the expression levels by more than eight times. (chinacrops.org)
For fungal heterologous expression, we used the well-studied A. nidulans containing the ΔnkuA deletion ( Table S1 ), which minimizes non-homologous recombination events 15 , 16 . (cdc.gov)
Networks of converging gene and enhancer modules were assembled into six and four global patterns of expression and activity across time. (jcbose.ac.in)
The recombinant aequorin gene from the jellyfish Aequorea victoria responsible for the expression of the Ca 2+ -sensitive aequorin photoprotein has been cloned in the filamentous fungus Aspergillus awamori . (biomedcentral.com)
Similarly, transformed cells grown on plastic have modified their gene expression to adapt to tissue culture conditions. (corning.com)

Using the sequence of PcbC, a key enzyme of β-lactam antibiotic biosynthesis, from eighteen different pro- and eukaryotic microorganisms, we have constructed a phylogenetic tree to demonstrate the distant relationship of both fungal producers. (biomedcentral.com)
Other genes not essential for β-lactam production are downregulated with a preference for those responsible for transport processes or biosynthesis of other secondary metabolites. (biomedcentral.com)
In both deletion strains, approximately 50% of all secondary metabolite cluster genes are differentially regulated, including β-lactam biosynthesis genes. (biomedcentral.com)
Novel genes involved in secondary metabolism, including genes implicated in ophiobolin biosynthesis, were identified. (nature.com)
A triazole antifungal agent that inhibits fungal cytochrome P450-mediated 14 alpha-lanosterol demethylation, which is essential in fungal ergosterol biosynthesis. (medscape.com)
At 250 Mb, the genome is also the smallest amongst grasses due to compaction of complex repeat and gene structures, including previously identified expansions in osmoprotectant biosynthesis pathways. (pacb.com)

The bacterium can complement the host enzymatic capabilities, alter the fungal metabolism, cell membrane composition but does not change the composition of the cell wall of the fungus. (frontiersin.org)
Bruce S. Klein of the University of Wisconsin-Madison and his colleagues disabled the B. dermatitidis gene for a protein called WI-1, which helps the fungus attach to host tissue. (sciencenews.org)
One fungus, which genes? (ugent.be)

Converted to fluorouracil after penetrating fungal cells. (medscape.com)

Is the Subject Area "Fungal genetics" applicable to this article? (plos.org)
Their studies, described online in PLoS Genetics, identified a wide range of genes that help explain this symbiotic success story. (labmanager.com)
Fungal Genetics and Biology. (rothamsted.ac.uk)
MacIntosh genetics features a hypersensitive cellular response to CAR invasion akin to what the Vf gene does for the so-called scab immune cultivars. (groworganicapples.com)
Since then it is involved in different aspects of fungal molecular genetics. (marinefungi.eu)

Analysis revealed deletion of DNA fragments with collinear gene order on chromosomes 1A, 2D, 5A, 5B, 5D and 7D of Chara HII mutants. (globalrust.org)

Molecular docking studies revealed interactions of CaDEFs with fungal plasma membrane components such as phosphatidylserine (PS) and glucosylceramide (GluCer) and their binding sites were identifed. (rothamsted.ac.uk)
Molecular fingerprinting and characterisation of the ARC's peach gene banks. (sun.ac.za)
With advancement in molecular biology and gene cloning techniques, research on fungal chitinases have made fast progress. (who.int)
Ivette was in the lab during November and December 2012 to learn algal molecular biology and clone a gene related to programmed cell death from Botryococcus braunii . (tamu.edu)

Antifungal antibiotics, frequently used in combination, are the mainstay of treatment of fungal endocarditis (FE). (medscape.com)

In fiscal year 2022, Connecticut continued monitoring these isolates for resistance genes. (cdc.gov)

Once the researchers narrowed the list of candidate genes, they used two complimentary approaches to find the Sr35 gene. (farms.com)
Analyses revealed key genomic regions associated with Lr34-functional resistance and we are in the process of validating candidate genes using qPCR. (globalrust.org)

Bierman, A Mapping and survey sequencing of Dn resistance genes in Triticum aestivum L. (sun.ac.za)
As a first line of defense, wheat breeders and researchers began looking for resistance genes among those that had already been discovered in the existing germplasm repositories, he said. (farms.com)

In this study for the first time we have demonstrated that the promoter of the gene from rumen bacteria can express a fungal gene. (tubitak.gov.tr)
When they switched off the genes responsible for producing oocydin A and when the bacteria were within an acidic background - such as that found inside a potato - it would switch on genes responsible for creating solanimycin. (cosmosmagazine.com)
It's an antifungal that we believe that will work by killing fungal competitors, and the bacteria benefit so much from this," said Monson. (cosmosmagazine.com)
Interestingly, the genes that allow the bacteria to metabolize sucrose and the genes that produce the phytohormones are located on a genomic island, suggesting they may have been acquired together via natural horizontal gene transfer," Taghavi said. (labmanager.com)

The elucidation of genetic relationships between the sets of genes provides important information for the development of recombinant microorganisms with potential industrial applications, they added, while simultaneously contributing to the understanding of the synergistic reactions among enzymes. (eurekalert.org)
Researchers spent nearly four years trying to identify the location of the Sr35 gene in the wheat genome, which contains nearly two times more genetic information than the human genome. (farms.com)
2007. Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study) . (hutton.ac.uk)

The localization of DEF and DEFL genes in chickpea genome revealed the presence of at least two clusters that are likely evolved through local gene duplications. (rothamsted.ac.uk)
20 kb) plasmids containing cloned gene clusters. (cdc.gov)
The wA locus in A. nidulans , which encodes a pigment-encoding and nonessential PKS 17 , was chosen as the site for homologous integration of the gene clusters ( Figures 2 and S1B ). (cdc.gov)
Of 60 blood cultures positive for Gram-positive cocci in clusters, LAMP (via detection of the FemA and MecA genes) showed 100% sensitivity and specificity for identification of MRSA/MSSA. (who.int)

A UCLA study has found that a common strain of Caenorhabditis elegans-a type of roundworm frequently used in laboratory research on neural development-has a pair of genes that encode both a poison and its antidote. (phys.org)

β-lactam antibiotics represent a large fraction of these drugs, and are the product of bacterial or fungal secondary metabolism. (biomedcentral.com)
This is essential as many genes of fungal secondary metabolism are inactive in axenic cultures. (degruyter.com)
The mechanism of action may involve increasing the permeability of the cell membrane, which, in turn, causes intracellular components to leak, alteration of RNA and DNA metabolism, or an intracellular accumulation of peroxide that is toxic to the fungal cell. (medscape.com)
The characterized genes have proposed functions involved in plant defense and stress, energy and metabolism, protein transport, replication, and RNA binding. (globalrust.org)

Few such modules were enriched in autism-associated genes and genomic variants in autistic children. (jcbose.ac.in)

Floor dust was collected and analyzed for bacterial (16 S rRNA gene) and fungal (internal transcribed spacer region) microbiota. (cdc.gov)
In this study, we determined the bacterial diversity profile of the Mexico City metro by massive sequencing of the 16S rRNA gene. (nature.com)

In addition, research included evaluation of ergosterol concentration and fungal bioaerosol particle size distribution. (springer.com)
Is ergosterol a good measure of fungal contamination in museums, archives and libraries? (springer.com)

To identify the resistance gene Sr35, the team turned to einkorn wheat that is known to be resistant to the Ug99 fungal strain. (farms.com)
From this strain, we further characterized a new more potent antifungal non-sulfated analogue, named notonesomycin B. Through CRISPR-Cas9 engineering of the biosynthetic gene cluster, we were able to increase the production yield of notonesomycin B by up to 18-fold as well as generate a strain that exclusively produces this analogue. (biomedcentral.com)

At present many microbial sources are being explored and tapped for chitinase production which includes potential fungal cultures. (who.int)

Fungal parasitism depends on the ability to invade host organisms and mandates adaptive cell wall remodeling to avoid detection and defense reactions by the host. (researchgate.net)
Based on real-time PCR analysis of basal defense genes and the Lr34 gene, we selected 72 hpi for RNA-seq with four biological replicates per condition. (globalrust.org)

Inhibiting fungal multidrug resistance by disrupting an activator-Mediator interaction. (harvard.edu)

These primers amplify approximately 717 bp of the coding region of the EF-1α gene. (cdc.gov)
These primers amplify approximately 495 bp of exons and introns at the 5' end of the β-tubulin gene. (cdc.gov)

The team's study, 'Identification of Wheat Gene Sr35 that Confers Resistance to Ug99 Stem Rust Race Group,' appears in the journal Science. (farms.com)
Until that point, wheat breeders had two or three genes that were so efficient against stem rust for decades that this disease wasn't the biggest concern,' Akhunov said. (farms.com)
The Sr35 gene was one of those genes that was discovered in einkorn wheat grown in Turkey,' Akhunov said. (farms.com)
Until now, however, we did not know what kind of gene confers resistance to Ug99 in this wheat accession. (farms.com)

Hibbett and Binder 2002) and analyses that combine protein-coding genes and rRNA genes (Matheny et al. (tolweb.org)

It was a matter of knocking out each candidate gene until we found the one that made a plant susceptible,' Akhunov said. (farms.com)
In the current study - through genome sequencing performed at DOE's Joint Genome Institute , manual genome annotation in collaboration with Brookhaven biologist Sebastien Monchy, and metabolic analyses performed at the University of South Carolina in collaboration with Brookhaven plant scientist Lee Newman - the scientists identified an extended set of genes that help Enterobacter (sp. (labmanager.com)
and genes that produce plant-growth enhancing "phytohormones" and precursors that poplar cannot produce on its own. (labmanager.com)
Other plant chitinases may be required for creating fungal symbioses. (wikipedia.org)
Plant Gene Silencing Humana Press Inc. (rothamsted.ac.uk)
2014. Links between plant and fungal communities across a deforestation chronosequence in the Amazon rainforest. . (umass.edu)

Unravelling such interactions could be useful in recreating the sponge microcosm conditions in vitro for harvesting novel fungal metabolites. (degruyter.com)

We have identified five genes in Saccharomyces cerevisiae, YIL008w (URM1), YHR111w (UBA4), YOR251c (TUM1), YNL119w (NCS2) and YGL211w (NCS6), that are required for 2-thiolation of mcm(5)s(2)U. An in vitro sulfur transfer experiment revealed that Tum1p stimulated the cysteine desulfurase of Nfs1p, and accepted persulfide sulfurs from Nfs1p. (nih.gov)

2014. Land use change alters functional gene diversity, composition and abundance in Amazon forest soil microbial communities. . (umass.edu)

The promoter region of the §-glucanase gene was identified using a transcriptional fusion between the upstream region of the Streptococcus bovis \beta-glucanase gene and the celA gene. (tubitak.gov.tr)
In the latter, the organization is identical in that both genes share a common promoter sequence. (biomedcentral.com)

Hydrolysis of untreated lignocellulosic feedstock is independent of S-lignin composition in newly classified anaerobic fungal isolate, Piromyces sp. (purdue.edu)
2007. Changes in fungal community composition in response to vegetational succession during the natural regeneration of cutover peatlands . (hutton.ac.uk)

This seminar will provide an introduction to Big Data and machine learning and potential public health applications, including examples from large scale analyses using National Health and Nutrition Examination Survey data to look at gene-environment interactions. (cdc.gov)

Resolving the Mortierellaceae phylogeny through synthesis of multi-gene phylogenetics and phylogenomics. (doe.gov)

Drug Resistance, Multiple, Fungal" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Drug Resistance, Multiple, Fungal" by people in Harvard Catalyst Profiles by year, and whether "Drug Resistance, Multiple, Fungal" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Drug Resistance, Multiple, Fungal" by people in Profiles. (harvard.edu)
To date, only half of these genes were known as candidates to confer drug resistance. (irbbarcelona.org)

for similar vaccines against more common fungal threats, say researchers. (sciencenews.org)
The researchers are now using DNA arrays -- DNA chips that can analyze the activity of thousands of genes simultaneously -- to understand how FLO11 works in conjunction with other genes to bring about this effect. (mit.edu)
Next, researchers isolated the candidate gene and used biotechnical approaches to develop transgenic plants that carried the Sr35 gene and showed resistance to the Ug99 race of stem rust. (farms.com)

In the immune system, the STAT3 protein regulates genes that are involved in the maturation of immune system cells, especially certain types of T cells . (medlineplus.gov)
ZNF341 gene mutations, which prevent production of functional ZNF341 protein, result in a shortage of STAT3 protein, leading to immune system problems similar to those caused by STAT3 gene mutations. (medlineplus.gov)
This gene, Sr35, functions as a key component of plants' immune system,' Akhunov said. (farms.com)

Their distribution in fungal genes shows that different motifs are found in orthologous genes and similar motifs are found in unrelated genes, suggesting that megasatellite formation or spreading does not necessarily track the evolution of their host genes. (archives-ouvertes.fr)

A multi-omics analysis revealed differentially active genes and enhancers during cortical development. (jcbose.ac.in)

I am assuming that it would be enzymatic vs fungal. (woodweb.com)
Both fungal and enzymatic can occur. (woodweb.com)
However, if you see fungal end stain, it is a good bet that the enzymatic has had the opportunity to be active as well. (woodweb.com)

SWM1, a developmentally regulated gene, is required for spore wall assembly in Saccharomyces cerevisiae. (1/10689)

NMD3 encodes an essential cytoplasmic protein required for stable 60S ribosomal subunits in Saccharomyces cerevisiae. (2/10689)

Characterization and expression of the cDNA encoding a new kind of phospholipid transfer protein, the phosphatidylglycerol/phosphatidylinositol transfer protein from Aspergillus oryzae: evidence of a putative membrane targeted phospholipid transfer protein in fungi. (3/10689)

Rpp14 and Rpp29, two protein subunits of human ribonuclease P. (4/10689)

The Saccharomyces cerevisiae CWH8 gene is required for full levels of dolichol-linked oligosaccharides in the endoplasmic reticulum and for efficient N-glycosylation. (5/10689)

Identification of yeasts by RFLP analysis of the 5.8S rRNA gene and the two ribosomal internal transcribed spacers. (6/10689)

The genes for the Golgi apparatus N-acetylglucosaminyltransferase and the UDP-N-acetylglucosamine transporter are contiguous in Kluyveromyces lactis. (7/10689)

The yeast dynamin-like protein, Mgm1p, functions on the mitochondrial outer membrane to mediate mitochondrial inheritance. (8/10689)

Help yeast genomic DNA library construction

Fungal and Yeast Genomic DNA Page 1

Fungal and Yeast Genomic DNA Page 1

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Fungal genome

Fungal DNA barcoding

Ochroconis gallopava

Metabolic gene cluster

Horizontal gene transfer

Thermostability

Gene regulatory circuit

Prp8

RNA virus

Lorna Casselton

$Expression of a Fungal Cellulase Gene by \beta-glucanase Promoter of S by MEHMET SAİT EKİNCİ$ "Expression of a Fungal Cellulase Gene by \beta-glucanase Promoter of S" by MEHMET SAİT EKİNCİ