The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.
A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.
The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The properties, processes, and behavior of biological systems under the action of mechanical forces.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.
Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.
The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)
Individual's rights to obtain and use information collected or generated by others.
A publication issued at stated, more or less regular, intervals.
A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.
"The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.
The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.
Experimentation on STEM CELLS and on the use of stem cells.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The study of natural phenomena by observation, measurement, and experimentation.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)
A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
The study of the origin, structure, development, growth, function, genetics, and reproduction of plants.
Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
The major group of transplantation antigens in the mouse.
A projective test used to evaluate a broad range of personality variables including pathology of thought and perception. The subject's responses to inkblot prints are scored along with subjective interpretation by the test administrator.
A major orthodox system of Hindu philosophy based on Sankhya (metaphysical dualism) but differing from it in being theistic and characterized by the teaching of raja-yoga as a practical method of liberating the self. It includes a system of exercises for attaining bodily or mental control and well-being with liberation of the self and union with the universal spirit. (From Webster, 3d ed)
A state of consciousness in which the individual eliminates environmental stimuli from awareness so that the mind can focus on a single thing, producing a state of relaxation and relief from stress. A wide variety of techniques are used to clear the mind of stressful outside interferences. It includes meditation therapy. (Mosby's Medical, Nursing, and Allied Health Dictionary, 4th ed)
Time period from 1901 through 2000 of the common era.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.
Time period from 2001 through 2100 of the common era.
An ethnic group with historical ties to the land of ISRAEL and the religion of JUDAISM.
The application of genetic analyses and MOLECULAR DIAGNOSTIC TECHNIQUES to legal matters and crime analysis.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
The relationships of groups of organisms as reflected by their genetic makeup.
Members of a Semitic people inhabiting the Arabian peninsula or other countries of the Middle East and North Africa. The term may be used with reference to ancient, medieval, or modern ethnic or cultural groups. (From Random House Unabridged Dictionary, 2d ed)
Damage or trauma inflicted to the eye by external means. The concept includes both surface injuries and intraocular injuries.

Enzymes and reproduction in natural populations of Drosophila euronotus. (1/18964)

Populations of Drosophila euronotus, one from southern Louisiana )3 samples), and one from Missouri (2 samples), were classified for allele frequencies at alkaline phosphatase (APH) and acid phosphatase (ACPH) loci. The two populations differed consistently in allele frequencies at both loci. The APH locus is on the inversion-free X chromosome; the chromosomal locus of the autosomal ACPH is unknown, and could involve inversion polymorphism. Wild females from Missouri and Louisiana populations heterozygous at the APH locus carried more sperm at capture than did the corresponding homozygotes. This heterotic association was significant for the combined samples, and whether it was the result of heterosis at the enzyme locus studied, or due to geographically widespread close linkage with other heterotic loci, it should help to maintain heterozygosity at the APH locus. In a Louisiana collection which included large numbers of sperm-free females, simultaneous homozygosity at both enzyme loci was significantly associated with lack of sperm. It is suggested that the latter association is the result of young heterozygous females achieving sexual maturity earlier than do the double homozygotes. The average effective sperm load for 225 wild females was only 29.4, suggesting the necessity for frequent repeat-mating in nature to maintain female fertility. A comparison of the sex-linked APH genotypes of wild females with those of their daughters indicated that among 295 wild-inseminated females from five populations, 35% had mated more than once, and of this 35%, six females had mated at least three times. Because of ascertainment difficulties, it is clear that the true frequency of multiple-mating in nature must have been much higher than the observed 35%. Laboratory studies indicate that multiple-mating in this species does not involve sperm displacement, possibly due to the small number of sperms transmitted per mating, and the fact that the sperm receptacles are only partially filled by a given mating.  (+info)

Marker effects on reversion of T4rII mutants. (2/18964)

The frequencies of 2-aminopurine- and 5-bromouracil-induced A:T leads to G:C transitions were compared at nonsense sites throughout the rII region of bacteriophage T4. These frequencies are influenced both by adjacent base pairs within the nonsense codons and by extracodonic factors. Following 2AP treatment, they are high in amber (UAG) and lower in opal (UGA) codons than in allelic ochre (UAA) codons. In general, 5BU-induced transitions are more frequent in both amber and opal codons than in the allelic ochre codons. 2AP- and 5BU-induced transition frequencies in the first and third positions of opal codons are correlated with those in the corresponding positions of the allelic ochre codons. Similarly, the frequencies of 2AP-induced transition in the first and second positions of amber codons and their ochre alleles are correlated. However, there is little correlation between the frequencies of 5BU-induced transitions in the first and second positions of allelic amber and ochre codons.  (+info)

Mapping of the homothallic genes, HM alpha and HMa, in Saccharomyces yeasts. (3/18964)

Two of the three homothallic genes, HM alpha and HMa, showed direct linkage to the mating-type locus at approximately 73 and 98 strans (57 and 65 centimorgans [cM], respectively, whereas, the other, HO, showed no linkage to 25 standard markers distributed over 17 chromosomes including the mating-type locus. To determine whether the HM alpha and HMa loci located on the left or right side of the mating-type locus, equations for three factor analysis of three linked genes were derived. Tetrad data were collected and were compared with expected values by chi 2 statistics. Calculations indicated that the HM alpha gene is probably located on the right arm at 95 strans (65 cM) from the centromere and the HMa locus at approximately 90 strans (64 cM) on the left arm of chromosome III.  (+info)

Insect evolution: Redesigning the fruitfly. (4/18964)

Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations.  (+info)

The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics. (5/18964)

Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative hybridization of the array with complex probes derived by reverse transcription of mRNA from brain and five other human tissues. Twenty-one percent of the clones corresponded to transcripts that could be classified in general categories of low, moderate, or high abundance. These expression profiles were integrated with cDNA clone and sequence clustering and gene mapping information from an upgraded version of the Genexpress Index. For seven gene transcripts found to be transcribed preferentially or specifically in brain, the expression profiles were confirmed by Northern blot analyses of mRNA from eight adult and four fetal tissues, and 15 distinct regions of brain. In four instances, further documentation of the sites of expression was obtained by in situ hybridization of rat-brain tissue sections. A systematic effort was undertaken to further integrate available cytogenetic, genetic, physical, and genic map informations through radiation-hybrid mapping to provide a unique validated map location for each of these genes in relation to the disease map. The resulting Genexpress IMAGE Knowledge Base is illustrated by five examples presented in the printed article with additional data available on a dedicated Web site at the address +/ welcome.html.  (+info)

Inhibition of cellular growth by increased guanine nucleotide pools. Characterization of an Escherichia coli mutant with a guanosine kinase that is insensitive to feedback inhibition by GTP. (6/18964)

In Escherichia coli the enzyme guanosine kinase phosphorylates guanosine to GMP, which is further phosphorylated to GDP and GTP by other enzymes. Here I report that guanosine kinase is subject to efficient feedback inhibition by the end product of the pathway, GTP, and that this regulation is abolished by a previously described mutation, gsk-3, in the structural gene for guanosine kinase (Hove-Jensen, B., and Nygaard, P. (1989) J. Gen. Microbiol. 135, 1263-1273). Consequently, the gsk-3 mutant strain was extremely sensitive to guanosine, which caused the guanine nucleotide pools to increase dramatically, thereby initiating a cascade of metabolic changes that eventually led to growth arrest. By isolation and characterization of guanosine-resistant derivatives of the gsk-3 mutant, some of the crucial steps in this deleterious cascade of events were found to include the following: first, conversion of GMP to adenine nucleotides via GMP reductase, encoded by the guaC gene; second, inhibition of phosphoribosylpyrophosphate synthetase by an adenine nucleotide, presumably ADP, causing starvation for histidine, tryptophan, and pyrimidines, all of which require PRPP for their synthesis; third, accumulation of the regulatory nucleotide guanosine 5',3'-bispyrophosphate (ppGpp), a general transcriptional inhibitor synthesized by the relA gene product in response to amino acid starvation.  (+info)

Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups. (7/18964)

The locus for the X-borne type of Charcot-Marie-Tooth muscular atrophy is not close to the Xg locus and probably not within direct measurable distance of it.  (+info)

Two-gene control of the expression of a murine Ia antigen. (8/18964)

Two dimensional polyacrylamide gel electrophoresis of Non-Idet P-40 extracts and of specific Ia immunoprecipitates from [35S]methionine-labeled mouse spleen lymphocytes has revealed that the cell surface expression of some Ia antigens appears to be controlled by two genes. One locus, which maps in the I-A subregion, is probably the structural gene for an Ia polypeptide chain. The second locus, which maps between the I-J and H-2D regions, controls whether this I-A encoded molecule (Ae) remains in the cytoplasm or is modified and expressed on the cell surface. Complementation between these two loci allowing surface expression of Ae can occur in the cis or trans chromosomal position. Both the I-A molecule and a polypeptide chain coded for by a locus in I-E are coprecipitated by anti-I-E antibodies, suggesting that these two chains are associated with each other as a multisubunit complex in the cell. Because the ability to complement I-A for Ae expression is a property only of those strains which synthesize an I-E-encoded protein, it is likely that the I-E product itself is regulating the expression of Ae. These observations suggest several mechanisms by which interaction between two I region loci can generate new cell surface molecules. As a result, they may have important implications for understanding the molecular basis of two gene control of immune responsiveness and immune suppression.  (+info)

View Notes - Biology 1201 from BIOL 1201 at LSU. Eucaryotic Gene Regulation Genome Structure, Genes, DNA, and chromosomes Complete Genome DNA sequence know humans ,chimps ,flies ,worms, and plants…
Mouse Major Urinary Protein 3 products available through Novus Biologicals. Browse our Mouse Major Urinary Protein 3 product catalog backed by our Guarantee+.
Using the dominant control region (DCR) sequences that flank the beta-globin gene locus, we have been able to achieve high-level expression of the human alpha-globin gene in transgenic mice. Expression in fetal liver and blood is copy number dependent and at levels comparable to that of the
Mutators can succeed: We have demonstrated that in continually changing environments where the adaptation to any given environmental state is independent of the adaptation to other states, mutator genes can climb to prominence by associated selection (i.e., by hitchhiking) with the linked beneficial mutations they generate. We have shown that even when mutators are extremely rare, there is a substantial probability that they will increase in frequency. We see this nonequilibrium analysis as a reminder that the average behavior of a process is sometimes an inadequate descriptor of the system as a whole. Although mutators are often lost in our model, in reality there would be recurrent mutation to the mutator state, and even if they are occasionally lost, organisms carrying a mutator gene would eventually dominate. Eventually, however, could be a very long time so that we should be unsurprised to sometimes observe low mutator frequencies even in systems that do conform to the assumptions of our ...
The methanol dehydrogenase gene mxaF, encoding the large subunit of the enzyme, was amplified from the DNA of a number of representative methanotrophs, methyletrophs, and environmental samples by PCR using primers designed from regions of conserved amino acid sequence identified by comparison of three known sequences of the large subunit of methanol dehydrogenase. The resulting 550-bp PCR products were cloned and sequenced. Analysis of the predicted amino acid sequences corresponding to these mxaF genes revealed strong sequence conservation. Of the 172 amino acid residues, 47% were conserved among all 22 sequences obtained in this study. Phylogenetic analysis of these MxaF sequences showed that those from type I and type II methanotrophs form two distinct clusters and are separate from MxaF sequences of other gram-negative methylotrophs. MxaF sequences retrieved by PCR from DNA isolated from a blanket bog peat core sample formed a distinct phylogenetic cluster within the MxaF sequences of type ...
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).. The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited by tetracycline. The transcription activator was a fused protein consisting of a tetracycline repressor gene (tetR) that was only active in the presence of tetracycline and a herpes simplex virus protein (VP-16) transcription activating domain (Tet-Off). Transcription was induced only in the absence of tetracycline (Tet-Off). A liver-specific promoter such as the mouse major urinary protein (MUP) promoter determined that the tetracycline-regulated transcriptional activator (tTA) would be expressed specifically in liver. To study the effect of the transcription activator on a target gene (for example, beta-galactosidase, LacZ) specifically in liver, MUP-tTA mice would be mated with transgenic mice in which the TAg Target gene was ...
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Complete information for LOC100420794 gene (Pseudogene), RE1 Silencing Transcription Factor Pseudogene, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for ATP5PBP6 gene (Pseudogene), ATP Synthase Peripheral Stalk-Membrane Subunit B Pseudogene 6, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Publisher: PLOS (Public Library of Science). Date Issued: 2015-08-10. Abstract: BACKGROUND Automatically detecting gene/protein names in the literature and connecting them to databases records, also known as gene normalization, provides a means to structure the information buried in free-text literature. Gene normalization is critical for improving the coverage of annotation in the databases, and is an essential component of many text mining systems and database curation pipelines. METHODS In this manuscript, we describe a gene normalization system specifically tailored for plant species, called pGenN (pivot-based Gene Normalization). The system consists of three steps: dictionary-based gene mention detection, species assignment, and intra species normalization. We have developed new heuristics to improve each of these phases. RESULTS We evaluated the performance of pGenN on an in-house expertly annotated corpus consisting of 104 plant relevant abstracts. Our system achieved an F-value of ...
Using the dominant control region (DCR) sequences that flank the beta-globin gene locus, we have been able to achieve high-level expression of the human alpha-globin gene in transgenic mice. Expression in fetal liver and blood is copy number dependent and at levels comparable to that of the endogenous mouse alpha-globin genes. Transgenic fetuses with high-copy numbers of the transgene suffer severe anemia and die before birth. Using a construct with both the human alpha- and beta-globin genes and the beta-globin DCR, live mice with low-copy numbers were obtained. Both human globin genes are expressed at high levels in adult red cells to give human hemoglobin HbA in amounts equal to or greater than endogenous mouse hemoglobin. Expression of HbA in murine red cells is not accompanied by any increase in mean corpuscular volume (MCV) or mean corpuscular hemoglobin concentration (MCHC). However, these transgenic mice tend to have an increased number of reticulocytes in peripheral blood; consistent with some
Caronte (es); Caronti (co); Charon (en-gb); Харон (bg); Charon (mythology) (simple); Charón (sk); Харон (uk); 카론 (ko); Karono (eo); Charón (cs); Haron (bs); Caront (an); Charon (fr); Haron (hr); Charon (thần thoại Hy Lạp) (vi); Charon (af); Харон (sr); Caronte (pt-br); Charon (sco); Charon (lb); Karon (nn); Kharon (nb); Charon (en); خارون (ar); Charon (br); Kharón (hu); Karonte (eu); Caront (ca); Charon (de-ch); Charon (cy); Carón (ga); خارون (fa); 卡戎 (zh); Charon (da); ქარონი (ka); カローン (ja); כארון (he); Charon (la); 卡戎 (wuu); Kharon (fi); Χάρων , Charōn (grc); Caronte (it); Charon (et); Haron (sh); Caronti (scn); Caronte (pt); Kharon (id); แครอน (th); Charon (en-ca); Charonas (lt); Haron (sl); Kharoon (tr); Харон (ru); Charon (de); Charon (war); Charon (pl); Charon (oc); Charon (nl); Харон (sr-ec); Charon (ro); Caronte (lij); Charon (nds); Caronte (gl); Charon (sv); Χάρων (el); Քարոն ...
Anthropogenetical Analysis of Abnormal Human -globin Gene Cluster Arrangement on Chromosome 16*. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
το κείμενο με τίτλο GPSy: a cross-species gene prioritization system for ... - HAL σχετίζετε με Βιοτεχνολογία
[Molecular mechanisms of globin gene regulation and disregulation].: Human globin genes are expressed in tissue and developmental stage specific manners. Variou
Previous work has suggested that the promoter regions of the human embryonic zeta 2 and epsilon globin genes contain negative regulatory regions that could play a role in the repression of these genes in postembryonic erythroblasts. We have examined this possibility by studying the expression of these genes in mouse erythroleukemia cells, an adult erythroid cell line that might be expected to contain repressor molecules that would bind to the putative negative regulatory regions. When attached to appropriate upstream regulatory elements (alpha HS-40 and beta HS1,2) both the zeta and epsilon genes were expressed in these cells at a low level, but no increase in expression was observed when similar constructs lacking the proposed negative regulatory sequences were introduced into these cells. These results cast doubt on the possibility that these sequences play a major role in the developmental repression of the embryonic globin genes, unless they function only in a normal chromosomal organization.
Histones are the major protein component of nucleosomes, and de novo histone synthesis is essential for packaging newly replicated DNA into chromatin. As a result, histone gene expression is exquisitely and functionally coupled with DNA replication. Vastly divergent organisms such as yeast, fly and human all demonstrate the phylogenetically conserved propensity to maintain clustering of histone genes at one or more genomic loci. Although specific mechanisms are unclear, clustering is presumed to be important for common stringent transcriptional control of these genes at the G1/S phase transition. In this study, we describe a genomic duplication of the human histone gene cluster located at chromosome 1q21, which effectively doubles the previously known size and gene number of that cluster. The duplication persists in all examined tissues and cell lines, and the duplicated genes are transcriptionally active. Levels of messenger RNAs for duplicated histone H4 genes are high relative to those for non
TY - JOUR. T1 - Hpal polymorphic site 3 of the human β-globin gene is inside a repetitive sequence and cannot be ascertained by polymerase chain reaction. AU - Wang, X.. AU - Bouhassira, Eric E.. PY - 1992. Y1 - 1992. KW - Haplotype. KW - Kpnl sequence. KW - PCR. UR - UR - M3 - Article. VL - 39. SP - 226. EP - 227. JO - American Journal of Hematology. JF - American Journal of Hematology. SN - 0361-8609. IS - 3. ER - ...
A 2.4 kb region of theEuglena gracilis chloroplast genome containing the genespsbT, psbH andpsbN was characterized. The mRNAs transcribed frompsbB, psbT, p
Exon sequences are conserved, but intron sequences vary, Organization of Genetic Material Split Genes, Overlapping Genes and Pseudogenes, Genetics
Cosmid clones containing alpha 1-antitrypsin (alpha 1AT) gene sequences were observed to contain alpha 1AT-like sequences approximately 12 kb downstream of the authentic alpha 1AT gene. Restriction mapping suggested the alpha 1AT-like gene lacks promoter sequences. Cosmid clones from one library con …
0001.scaffold00002 AUGUSTUS gene 1386 2772 0.12 + . ID=Bv_00001z1_qhas;Name=Bv_00001z1_qhas 0001.scaffold00002 AUGUSTUS mRNA 1386 2772 0.12 + . ID=Bv_00001z1_qhas.t1;Parent=Bv_00001z1_qhas;Name=Bv_00001z1_qhas.t1 0%;Note=cDNAcoverage_0% 0001.scaffold00002 AUGUSTUS five_prime_UTR 1386 1976 . + . ID=Bv_00001z1_qhas.t1.UTR;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS start_codon 1977 1979 . + 0 ID=Bv_00001z1_qhas.t1.start_codon;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS CDS 1977 2325 0.96 + 0 ID=Bv_00001z1_qhas.t1.CDS;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS intron 2326 2619 0.81 + . ID=Bv_00001z1_qhas.t1.intron;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS CDS 2620 2747 0.8 + 2 ID=Bv_00001z1_qhas.t1.CDS;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS stop_codon 2745 2747 . + 0 ID=Bv_00001z1_qhas.t1.stop_codon;Parent=Bv_00001z1_qhas.t1 0001.scaffold00002 AUGUSTUS three_prime_UTR 2748 2772 . + . ID=Bv_00001z1_qhas.t1.UTR;Parent=Bv_00001z1_qhas. ...
Each gene with an approved VGNC symbol has its own Symbol Report that contains our manually curated data and links to other external biomedical resources. The VGNC core data is displayed at the top of the page in a separate box and presents the approved nomenclature, the unique VGNC ID number, aliases, previous nomenclature, locus type, chromosomal location and gene group. The table below the VGNC core data provides links to external resources such as homologs in other species, gene resources, protein resources, and publications. ...
Opens the Highlight Feature Bar and highlights feature annotations from the FEATURES table of the record. The Highlight Feature Bar can be used to navigate to and highlight other features and provides links to display the highlighted region separately. Links in the FEATURES table will also highlight the corresponding region of the sequence. More... ...
A 350-bp segment of DNA associated with an erythroid-specific DNase I-hypersensitive site (HS-40), upstream of the alpha-globin gene cluster, has been identified as the major tissue-specific regulator of the alpha-globin genes. However, this element does not direct copy number-dependent or developmentally stable expression of the human genes in transgenic mice. To determine whether additional upstream hypersensitive sites could provide more complete regulation of alpha gene expression we have studied 17 lines of transgenic mice bearing various DNA fragments containing HSs -33, -10, -8, and -4, in addition to HS -40. Position-independent, high-level expression of the human zeta- and alpha-globin genes was consistently observed in embryonic erythroid cells. However, the additional HSs did not confer copy-number dependence, alter the level of expression, or prevent the variable down-regulation of expression in adults. These results suggest that the region upstream of the human alpha-globin genes is not
The International System for Human Gene Nomenclature (ISGN) was inaugurated in 1979, and has been continually updated. The Human Gene Mapping Nomenclature Committee, which developed the ISGN, put forth a
The International System for Human Gene Nomenclature (ISGN) was inaugurated in 1979, and has been continually updated. The Human Gene Mapping Nomenclature Committee, which developed the ISGN, put forth a
Rat Genomic DNA High molecular weight, high purity DNA for any application - Find MSDS or SDS, a COA, data sheets and more information.
You searched for: Journal Theoretical and applied genetics Remove constraint Journal: Theoretical and applied genetics Source 1990 v.80 no.3 Remove constraint Source: 1990 v.80 no.3 Subject DNA Remove constraint Subject: DNA Subject restriction mapping Remove constraint Subject: restriction mapping ...
Consider two unlinked genes P and Q A plant with genotype PPQQ was crossed with another plant with genotype ppqq to obtain F1 progeny If the F1 progeny to testcrossed the percentage of resultant plants
inproceedings{8564264, author = {{Mus, Liselot and Denecker, Geertrui and Zeltner, Nadja and Ogando, Yudelca and Van Haver, Stéphane and Sanders, Ellen and Jacobs, Eva and Popovic, Mina and Van Neste, Christophe and Vanhauwaert, Suzanne and Durinck, Kaat and Menten, Björn and De Preter, Katleen and Heindryckx, Björn and Studer, Lorenz and Roberts, Stephen and Speleman, Franki}}, booktitle = {{Advances in Neuroblastoma Research, Congress abstracts}}, language = {{eng}}, location = {{San Fransisco, CA, USA}}, title = {{Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation}}, year = {{2018 ...
Distribution of the mRNA/peptide in the cardiovascular system Southern blot analysis of human genomic DNA under low hybridization stringency with a 42-mer synthetic oligonucleotide probe corresponding to amino acid residues 7-20 of ET, showed that three different restriction fragments were always detected regardless of the restriction endonucleases used. The nucleotide sequences encoding amino acid residues of the three ETs are highly conserved among the three genes, with 77-82% of the nucleotide residues being identical [2]. By contrast, the nucleotide sequences upstream from the mature peptides are very poorly conserved. These observations suggest that although the three genes are evolutionally relatively distant from each other, the genes evolved from a common ancestral gene under strong pressure to preserve mature ET sequences. The three peptides were designated ET-1, ET-2 and ET-3 [5]. ET-1 is the original peptide corresponding to that detected in the culture medium of porcine aortic ...
We previously reported the isolation and characterization of a cDNA clone, I-309, that encodes a small secreted protein produced by activated human T lymphocytes. This protein is structurally related to a large number of recently identified proteins that are secreted upon cellular activation. In this report we describe the isolation and characterization of the gene encoding I-309. The genomic organization is essentially identical to that found in the genes encoding the structurally similar proteins TCA-3, hJE/MCP-1, and mJE, strengthening the hypothesis that these genes are evolutionarily related. The region of the I-309 gene 5 of the mRNA cap site exhibits extensive nucleotide sequence homology with the same region of the murine gene TCA-3, providing additional evidence that I-309 and TCA-3 are likely to be homologs. Finally, panels of rodent-human somatic cell hybrids were used to map the I-309 gene to human chromosome 17. In conjunction with recent mapping data from other laboratories, this ...
A multiple catheter assembly (100) including a first catheter (110) constructed from a first material and having a first proximal end region (112), a first distal end region (114) terminating in a first distal tip (116), and an outer surface (120) defining at least a first lumen (122) extending longitudinally therethrough between a first distal (118) and a first proximal (111) opening. The first proximal end region (112) is integrally connected to an extension tube (320) constructed from a second material. A second catheter (130) is constructed from the first material and having a second proximal end region (132), a second distal end region (134) terminating in a second distal tip (136), and a second outer surface (140) defining at least a second lumen (142) extending longitudinally therethrough between a second distal (138) and a second proximal (131) opening. The second proximal end region (132) is integrally connected to an extension tube (350) constructed from the second material. The first lumen
We have cloned and characterized the Na,K-ATPase β3 subunit gene (ATP1B3), and a β3 subunit pseudogene (ATP1B3P1), from a human PAC genomic library. The β3 subunit gene is > 50 kb in size and is split
Bordelon, M R., Malignant characteristics of somatic cell hybrids of normal human and malignant mouse cells. Abstr. (1974). Subject Strain Bibliography 1974. 446 ...
Eiglmeier, K., W. Boos, S.T. Cole 1987. Nucleotide sequence and transcriptional startpoint of the glpT gene of Escherichia coli: extensive sequence homology of the glycerol-3-phos transport protein with components of the hexose-6-phos transport system ...
The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.. Online ISSN: 1943-2631. ...
MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter.[5] Its official full name is meningioma ( ... in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8 ... in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8 ... "MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression". ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... Genes[edit]. Acne appears to be strongly inherited; genetics explain 81% of the variation in the population.[15] Studies ... among others.[19] The 308 G/A single nucleotide polymorphism variation in the gene for TNF is associated with an increased risk ... Acne susceptibility is likely due to the influence of multiple genes, as the disease does not follow a classic (Mendelian) ...
Genes[edit]. Number of genes[edit]. The following are some of the gene count estimates of human chromosome 16. Because ... Gene list[edit]. See also: Category:Genes on human chromosome 16.. The following is a partial list of genes on human chromosome ... So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[5] ... "HUGO Gene Nomenclature Committee. 2017-05-12. Retrieved 2017-05-19.. *^ "Chromosome 16: Chromosome summary - Homo sapiens". ...
This affects their function of gene regulation. In general, genes that are active have less bound histone, while inactive genes ... Repressed genes[edit]. Three histone modifications are particularly associated with repressed genes: Trimethylation of H3 ... Hannon Bozorgmehr J (Oct 2019). "The origin of chromosomal histones in a 30S ribosomal protein". Gene. doi:10.1016/j.gene. ... Histone gene transcription is controlled by multiple gene regulatory proteins such as transcription factors which bind to ...
Different genes on different loci would need to be selected for another fly species. The genes expressions are mapped in a ... the older the egg is the more of the particular gene is expressed.[33] However, all of the genes are expressed in varying ... Gene expression studies[edit]. Although physical characteristics and sizes at various instars have been used to estimate fly ... This is done by breaking the stages down into smaller units separated by predictable changed in gene expression.[33] Three ...
Genes[edit]. PEX genes encode the protein machinery ("peroxins") required for proper peroxisome assembly, as described above. ... Genes that encode peroxin proteins include: PEX1, PEX2 (PXMP3), PEX3, PEX5, PEX6, PEX7, PEX10, PEX11A, PEX11B, PEX11G, PEX12, ... doi:10.1016/j.gene.2009.09.014. PMID 19818387.. *^ Gabaldón T, Capella-Gutiérrez S (Oct 2010). "Lack of phylogenetic support ... for a supposed actinobacterial origin of peroxisomes". Gene. 465 (1-2): 61-5. doi:10.1016/j.gene.2010.06.004. PMID 20600706.. ...
Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ... Gene ontology. Molecular function. • receptor binding. • neurotrophin TRKB receptor binding. • growth factor activity. • GO: ... The BDNF protein is encoded by a gene that is also called BDNF, found in humans on chromosome 11.[7][8] Structurally, BDNF ...
Gene therapy[edit]. Gammaretroviral and lentiviral vectors for gene therapy have been developed that mediate stable genetic ... For example, the gag gene is translated into molecules of the capsid protein, the pol gene is translated into molecules of ... Rous sarcoma virus contains the src gene that triggers tumor formation. Later it was found that a similar gene in cells is ... transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new ...
Gene[edit]. The human TNF gene (TNFA) was cloned in 1985.[22] It maps to chromosome 6p21.3, spans about 3 kilobases and ... Gene ontology. Molecular function. • transcription regulatory region DNA binding. • protein binding. • protease binding. • ... negative regulation of gene expression. • protein localization to plasma membrane. • positive regulation of protein catabolic ... positive regulation of gene expression. • extrinsic apoptotic signaling pathway. • extrinsic apoptotic signaling pathway via ...
Hallmarks include mutations to the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and ... A gene called c9orf72 was found to have a hexanucleotide repeat in the non-coding region of the gene in association with ALS ... To date, multiple genes and proteins have been implicated in ALS. One of the common themes between many of these genes and ... Entrez Gene. "BDNF". United States National Center for Biotechnology Information.. *^ Kim J, Inoue K, Ishii J, Vanti WB, ...
In nature, such genes exist in several different forms and are therefore said to have multiple alleles. A gene with more than ... Traits controlled by two or more genes are said to be polygenic traits. Polygenic means "many genes." For example, at least ... An organism that has two identical alleles for a gene is said to be homozygous for that gene (and is called a homozygote). An ... Many other genes have multiple alleles, including the human genes for ABO blood type. ...
Gene structure[edit]. In humans, the IGF2 gene is located on chromosome 11p15.5, a region which contains numerous imprinted ... Gene ontology. Molecular function. • insulin receptor binding. • hormone activity. • GO:0001948 protein binding. • growth ... regulation of gene expression by genetic imprinting. • skeletal system development. • cellular protein metabolic process. • ... The protein CTCF is involved in repressing expression of the gene, by binding to the H19 imprinting control region (ICR) along ...
Gene[edit]. The AKR1B1 gene lies on the chromosome location of 7q33 and consists of 10 exons. There are a few putative ... Gene ontology. Molecular function. • aldo-keto reductase (NADP) activity. • electron carrier activity. • oxidoreductase ... Graham A, Brown L, Hedge PJ, Gammack AJ, Markham AF (April 1991). "Structure of the human aldose reductase gene". The Journal ... Graham A, Heath P, Morten JE, Markham AF (March 1991). "The human aldose reductase gene maps to chromosome region 7q35". Human ...
Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ... The BDNF protein is encoded by a gene that is also called BDNF, found in humans on chromosome 11.[6][7] Structurally, BDNF ... Common SNPs in BDNF gene[edit]. BDNF has several known single nucleotide polymorphisms (SNP), including, but not limited to, ...
Gene and regulation[edit]. P-selectin is located on chromosome 1q21-q24, spans , 50 kb and contains 17 exons in humans.[7] P- ... Gene ontology. Molecular function. • heparin binding. • oligosaccharide binding. • lipopolysaccharide binding. • calcium- ... P-selectin is a protein that in humans is encoded by the SELP gene.[5] ... Pan J, Xia L, McEver RP (April 1998). "Comparison of promoters for the murine and human P-selectin genes suggests species- ...
2 Gene content and plastid gene expression *2.1 Chloroplast genome reduction and gene transfer ... In most plant species, the chloroplast genome encodes approximately 120 genes.[23][24] The genes primarily encode core ... Chloroplasts may contain 60-100 genes whereas cyanobacteria often have more than 1500 genes in their genome.[27] Contrarily, ... corresponding to about 4,500 protein-coding genes.[33] There have been a few recent transfers of genes from the chloroplast DNA ...
Gene and transcription[edit]. Obestatin is encoded by the same gene that encodes ghrelin, a peptide hormone. The mRNA produced ... Seim I, Amorim L, Walpole C, Carter S, Chopin LK, Herington AC (2010). "Ghrelin gene-related peptides: multifunctional ... removing the ghrelin gene from mice did not significantly reduce food intake. No secretory convertase is capable of cleaving ... a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science. 310 (5750): 996-9. doi:10.1126/ ...
Gene regulation[edit]. Main article: Regulation of gene expression. At the cellular level, homeostasis is carried out by ... At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or ... several mechanisms including transcriptional regulation that can alter the activity of genes in response to changes. ...
MDR1 gene mutation[edit]. Recent research at Washington State University indicates that, in addition to many other herding ... breeds, approximately 15% of the English Shepherd population is subject to the MDR1 gene mutation. Dogs that are tested ...
Gene therapy. Gene therapy typically involves the use of a non-infectious virus (i.e., a viral vector such as the adeno- ... SNCA gene mutations are important in PD because the protein which this gene encodes, alpha-synuclein, is the main component of ... Genes implicated in the development of PD include SNCA, LRRK2, GBA, PRKN, PINK1, PARK7, VPS35, EIF4G1, DNAJC13 and CHCHD2.[50] ... The gene used leads to the production of an enzyme that helps to manage PD symptoms or protects the brain from further damage.[ ...
Gene prediction. References[edit]. *^ a b Shine, J.; Dalgarno, L. (1975-03-06). "Determinant of cistron specificity in ... Gene Expression Technology. 185. Academic Press. pp. 103-114.. *^ Stormo, Gary D.; Schneider, Thomas D.; Gold, Larry M. (1982- ... Gene annotation[edit]. The identification of RBSs is used to determine the site of translation initiation in an unannotated ... "Genes & Development. 15 (13): 1593-1612. doi:10.1101/gad.891101. ISSN 0890-9369. PMID 11445534.. ...
Epigenetic gene silencing of DNA repair genes occurs frequently in NSCLC. At least nine DNA repair genes that normally function ... Epigenetic promoter methylation in DNA repair genes in NSCLC Gene Frequency of hyper- (or hypo-) methylation DNA repair pathway ... ALK gene rearrangements[edit]. Up to 7% of NSCLC patients have EML4-ALK translocations or mutations in the ROS1 gene; these ... Gomes A, Reis-Silva M, Alarcão A, Couceiro P, Sousa V, Carvalho L (2014). "Promoter hypermethylation of DNA repair genes MLH1 ...
If a resistance gene is transferable, it could lessen the effect of the use of antibiotics. Out of ten common antibiotic genes ... Transferable Resistance Genes[edit]. One important consideration to determine the safety of Lactobacillus fermentum is ... In order for L. fermentum to be considered as a potential probiotic, it must not contain any transferable resistant genes. ... They are considered potential vectors of antibiotic resistance genes from the environment to humans or animals to humans.[9] ...
Natural products genes[edit]. S. lacrymans' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal ... NPS3 and its adjacent clustered aminotransferase gene (AMT1) were also found to be up-regulated during co-incubation with ... One genome is from Serpula lacrymans S7.9 (v2.0). The genome assembly is 42.73 Mbp, with a predicted number of 12789 genes. The ... second genome is from Serpula lacrymans S7.3 (v2.0). The genome assembly is 47 Mbp, with a predicted number of 14495 genes. The ...
Gene and protein expression[edit]. About 20,000 protein-coding genes are expressed in human cells and nearly 70% of these genes ... Some 250 of these genes are more specifically expressed in the esophagus with less than 50 genes being highly specific. The ... Many genes with elevated expression are also shared with skin and other organs that are composed of squamous epithelia.[25] ... "Expression of Human Skin-Specific Genes Defined by Transcriptomics and Antibody-Based Profiling". Journal of Histochemistry & ...
Other MCPH genes[edit]. In addition to MCPH1, other genes have been designated MCPH genes based on their role in brain size. ... and common genetic variants within both the MCPH1 gene and another similarly studied microcephaly gene, CDK5RAP2.[12] ... regulation of gene expression. • regulation of kinase activity. • regulation of centrosome cycle. • regulation of inflammatory ... Lahn is now engaging himself with other areas of study.[22][23] Later studies have not found those gene variants to be ...
Gene[edit]. The human CysLTR2 gene maps to the long arm of chromosome 13 at position 13q14, a chromosomal region that has long ... The gene consists of four exons with all introns located in the genes' 5' UTR region and the entire coding region located in ... "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2".. *^ Thompson MD, Takasaki J, Capra V, Rovati GE, Siminovitch KA, ... Gene ontology. Molecular function. • protein binding. • G-protein coupled peptide receptor activity. • signal transducer ...
Regulation of gene expression[edit]. The regulation of gene expression of hemolysins (such as streptolysin S) is a system ...
Gene ontology. Molecular function. • calcium ion binding. • protein binding. • ankyrin binding. • gamma-catenin binding. • beta ... "Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)".. *^ Fleming TP, Papenbrock T, Fesenko I, Hausen P, Sheth B ( ... Berx G, Becker KF, Höfler H, van Roy F (1998). "Mutations of the human E-cadherin (CDH1) gene". Human Mutation. 12 (4): 226-37 ... Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is ...
... since the child receives genes and gene regulatory molecules from two different women. Using genetic engineering in attempts to ... Gene therapy prior to conception[edit]. Spindle transfer, where the nuclear DNA is transferred to another healthy egg cell ... Defects in enzymes that control mitochondrial DNA replication (all of which are encoded for by genes in the nuclear DNA) may ... Mitochondrial disorders may be caused by mutations (acquired or inherited), in mitochondrial DNA (mtDNA), or in nuclear genes ...
Genes contained within the family: 15 Approved Symbol. Approved Name. Previous Symbols. Synonyms. Chromosome. ...
Please see our Protein phosphatases, catalytic subunits page to view the PPP1C genes, along with all other PPP genes. ... Genes contained within the family: 181 Approved Symbol. Approved Name. Previous Symbols. Synonyms. Chromosome. ...
Gene activation, the first step of protein production, starts less than one millisecond after a cell is stretched-hundreds of ... Cells will ramp up gene expression in response to physical forces alone, a new study finds. ... "The genes near the nuclear periphery cannot be activated even if you stretch them, whereas the genes that are close to the ... Force triggers gene expression by stretching chromatin More information: "Force-induced gene up-regulation does not follow the ...
These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a ... has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in ... Among the genes identified was CD276, a gene that encodes a protein located on the cell surface, as well as other known and ... NCI Researchers Discover Genes That Are Turned On at High Levels in Tumor-Associated Blood Vessels of Mice and Humans. ...
... and ex vivo gene transfer. This was the first NIH Office of Recombinant DNA Activities-approved trial of human gene therapy for ... Carducci M. A., Ayyagari S. R., Sanda M. G., Simons J. W. Gene therapy for human prostate cancer. Cancer (Phila.), 75: 2013- ... GM-CSF gene-transduced PCA vaccines represent only one of several new approaches to active specific immunotherapy of PCA, which ... GM-CSF gene-transduced PCA vaccines increased antibody titers against prostate tumor cell line-associated antigens. This ...
Once Notch is activated, the activity of proneural genes decreases in these cells, probably due to the activation of genes in ... On the other hand, proneural genes mutants fail to develop neural precursor cells. The proneural genes are expressed in groups ... Skeath, J. B.; Panganiban, G. F.; Carroll, S. B. (1994). "The ventral nervous system defective gene controls proneural gene ... Co-expression of proneural genes in brain neuroblasts is transient and varies with the developmental stage. Proneural gene ...
Explore the normal functions of human genes and the health implications of genetic changes. ...
The classic culture-gene example is the rapid rise of a gene for digesting lactose. If you lack this gene, youll have trouble ... Culture and genes started selecting for each other: A new culture made a gene more valuable, and as the gene spread through the ... no one gene or set of genes can hardwire us for exploration. More likely, different groups of genes contribute to multiple ... Sometimes a gene rides such a wave passively, more or less by accident-the gene just happens to be common in the leading ...
Table: Selected genes with variants that have been associated with obesity. Gene symbol. Gene name. Gene products role in ... Genes are the basis for the signals and responses that guide food intake, and small changes in these genes can affect their ... Insulin-induced gene 2. Regulation of cholesterol and fatty acid synthesis. MC4R. Melanocortin 4 receptor. When bound by alpha- ... What do genes have to do with obesity?. Obesity is the result of chronic energy imbalance in a person who consistently takes in ...
Explore the normal functions of human genes and the health implications of genetic changes. ... URL of this page: Genes: D. ...
Its the old genes plus environment story, and its typically cast in a negative light. ... He adds an important amendment to the vulnerability hypothesis, which holds that certain genes make people more vulnerable to ... Gene variants generally considered misfortunes (poor Jim, he got the "bad" gene) can instead now be understood as highly ... If variants of certain genes create mainly dysfunction and trouble, how have they survived natural selection? Genes so ...
Holmes, Andrew (2012). "Genes, Brain and Behavior: At the vanguard of behavioral and genomic neuroscience". Genes, Brain and ... "OnlineOpen". Genes, Brain and Behavior. Wiley-Blackwell. Retrieved 2013-09-20. "Author Guidelines". Genes, Brain and Behavior. ... "Source details: Genes, Brain and Behavior". Scopus preview. Elsevier. Retrieved 2017-01-28. "Genes, Brain and Behavior". ... have cited Genes, Brain and Behavior most often, are (in order of descending citation frequency) PLoS ONE, Genes, Brain and ...
Guest Cabin. The main house and guest cabin have undergone extensive modernizing with new roofs, decks, windows, carpets, tile, etc. The bunkhouse is newly built in 2012. New furniture and other modern amenities have been added. The location is about 20 minutes from Portland. It is a perfect summer retreat. Features to keep you connected with the ongoing world include cable and high speed wireless internet. A boat ramp and a mooring is available. . The Sebago Lake Basin is a great place to vacation with the family. Plenty of local daytime activities including the JCC Day Camp. Nearby attractions include several movie theaters and amusement parks. This property is located within 1 mile of Wal-Mart, Hannaford, Shaws, Dunkin Donuts and Gilberts Chowder House. A recently added feature at Lonely Planet is an excellent guide to Portland Maine.. The neighborhood association sprays for mosquitoes. So it is a pleasant outdoor experience!. Be sure to check out our sister properties at Lady Pepperell ...
... If an article discusses basic biology of a gene/protein from certain organisms, indexers must also link the gene ... The gene/protein must be the main focus of the article. The list of organisms for which gene links are made is growing ... to the appropriate record in the NCBI database called Gene. ...
... brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes ... Celebrating 25 Years of Gene Therapy To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the most ... 25 Years of Gene Therapy. To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the journals most ... Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components * ...
The Genes & Cells page features the latest news in genetics, cells, development, physiology, immune science, microbiology, ... Jumping genes are part of all that makes us human. Ask 10 people what makes humans human and youll probably get 10 different ... Current CRISPR gene drives are too strong for outdoor use, studies warn. Self-limiting genetic tools already in development may ... 25 SN: Charting lumpy space, Bronze Age movers and shakers, T. rexs slasher arms, gene editor corrects typos, the Great ...
The Genes & Cells page features the latest news in genetics, cells, development, physiology, immune science, microbiology, ... Jumping genes are part of all that makes us human. Ask 10 people what makes humans human and youll probably get 10 different ... Genes could record forensic clues to time of death. Scientists have found predictable patterns in the way our genetic machinery ... FORENSIC LENS A new approach to determining a bodys time of death looks for patterns in genes that are active after death. ...
Researchers uncover gene mutations that contribute to disease by screening the genomes of thousands of healthy and ill people ... Sick Genes. Researchers uncover gene mutations that contribute to disease by screening the genomes of thousands of healthy and ... "Its not about one gene.". Nevertheless, on average, having one copy of some of the newly identified genes raises a persons ... For example, researchers probing type 1 diabetes report in Nature and Nature Genetics that they found seven new genes and ...
Source for information on histocompatibility genes: A Dictionary of Plant Sciences dictionary. ... histocompatibility genes The genes for antigens that are responsible for the acceptance or rejection of foreign bodies in the ... Regulator Gene , regulatory gene In the operon theory of gene regulation, a gene that is involved in switching on or off the ... It is a cluste… gene family , gene family A group of similar or identical genes, usually along the same chromosome, that ...
Genes to Cognition presents supporting information for grades 9-12 on cognitive disorders, cognitive processes, and research ... Genes To Cognition. By Phil Nast, retired middle school teacher and freelance writer ... Simple Mapper was used to organize the Genes to Cognition website and the software is available for free. Registration is ... And the heading Research Approaches includes information about bioinformatics, ethics, gene finding, model systems, ...
The Hox genes are powerful regulators of other genes activities, and they also get re-used for other functions. Certain Hox ... Hox genes are members of a family of genes with a number of common attributes:. *They all contain a common 183-basepair ... Since Hox genes activate and are activated, I assume they may also be regulated by other genes, or perhaps they regulate ... They are all regulatory genes that bind DNA to switch other genes off and on. ...
Speciation genes.. Orr HA1, Masly JP, Presgraves DC.. Author information. 1. Department of Molecular Biology & Genetics, ... Until recently, the genes that cause reproductive isolation remained black boxes. Consequently, evolutionary biologists were ... Molecular evolutionary study of the genes causing reproductive isolation may represent an important new phase in the study of ... Evolutionary analysis of these genes suggests that speciation results from positive Darwinian selection within species. ...
Wnt genes.. Nusse R1, Varmus HE.. Author information. 1. Howard Hughes Medical Institute, Stanford University School of ...
Also see: Catalog of Gene Symbols for Wheat**. Wheat rusts: An atlas of resistance genes.** By R. McIntosh, C. Wellings and R. ... Special thanks to Xianming Chen for updating the Yr resistance gene file.. ...
... includes meditation and breathing practical exercises, as well as information on how to manage risk factors for ... For years it was accepted knowledge that genes were fixed components of our bodies, and that we as individuals were incapable ... Instead, they argue, we have the power to rewire our super genes for health and happiness. ... when he participated in the first study using genetic markers to find a disease gene (Huntingtons disease). Dr Tanzi isolated ...
main questions was:community of J.genes,links to neighbours of diaspora and Middle East genes.As allways these links must be ... If your gene pool and your history say you are then you are, no one should ever have that right and their history taken away ... For one, genes of course do not make a cultural identity or religoius identity. They can however show a link to a particular ... I would say you have more Jewish genes then I do, frankly I would consider you as a Jew. It makes me angry that we dont accept ...
Predicting eye colour from genes. Fan Liu, Kate van Duijn, Johannes R. Vingerling, Albert Hofman, André G. Uitterlinden, A. ... The authors examined all of the 37 variants (in 8 separate genes) previously reported to have an association with eye colour in ... In addition to being a tempting target for cosmetic genetic screening by parents undergoing IVF, eye colour genes will no ... these markers were typically captured by other variants within the same gene). ...
Gene Hackman, Actor: The French Connection. Eugene Allen Hackman was born in San Bernardino, California, the son of Anna Lyda ... McLean Stevenson/Gene Hackman/George Carlin/Gloria DeHaven (1974) ... Himself - McLean Stevenson, George Carlin, Gene Hackman, ... Steve Allen, John Wayne, Carol Channing, Charles Nelson Reilly, Terry-Thomas, Jo Ann Pflug, Gene Hackman (1972) ... Himself - ... How much of Gene Hackmans work have you seen? .aux-content-widget-2.poll-widget-rhs ul li { margin-bottom: 0.5em; clear: left ...
Phylogenetic profiling of essential genes. The 271 B. subtilis genes were grouped in 266 clusters. Only one gene, yhdL, which ... The essential ddl gene is required for synthesis of the dipeptide d-Ala-d-Ala. (iv) Eight essential genes, murAA, murB, C, D, E ... They comprise five genes involved in the initiation of replication (dnaA, B, D, and I, and priA), eight genes encoding ... Only four genes are involved in regulation of RNA synthesis: a two-component system yycF and G (12), a gene involved in the ...
... and do not all lie within genes or themselves alter the function of genes. ... "The number of genes linked to the bowel condition Crohns disease has been trebled by research that provides promising targets ... The newspaper said that the discovery of 21 new genes raises to 32 the number of "DNA passages known to raise susceptibility to ... The study behind this story provides good evidence that there are a large number of genes that can increase a persons ...
  • How are genetic conditions and genes named? (
  • AML is the result of acquired genetic changes in the blood-forming stem cells and among other things affects genes that control the cells' maturation and growth. (
  • Explore the normal functions of human genes and the health implications of genetic changes. (
  • It's about hundreds of genes in your genome contributing a threshold of genetic susceptibility," Todd says. (
  • For years it was accepted knowledge that genes were fixed components of our bodies, and that we as individuals were incapable of altering our genetic make-up. (
  • In addition to being a tempting target for 'cosmetic' genetic screening by parents undergoing IVF, eye colour genes will no doubt prove useful in forensic applications - being able to predict *any *physical traits from trace DNA left at the scene of a crime will at least occasionally be useful for investigators. (
  • The variations the researchers looked at were scattered throughout the genetic sequence, and do not all lie within genes or themselves alter the function of genes. (
  • They also looked at which genes lay near the variants identified, and whether their variants were close ("linked") to any variants within the genes themselves, using a database of common genetic variants in humans (the HapMap). (
  • A new article in AFRICANA.COM suggests that if we choose to ignore genetic differences between groups of people in the interest of political correctness, we're deceiving ourselves and may be worsening the effects of some serious gene-related health problems around the globe. (
  • The overlap between autism susceptibility genes and genes previously implicated in intellectual disabilities further supports the hypothesis that at least some genetic risk factors are shared by different psychiatric developmental disabilities. (
  • GENES-R-US is a genetic counseling service created and designed by a high school biology class and offered to high school health class (or home economics class) "couples expecting a child" as part of a family living project. (
  • The program asks the student couple if they would like to subscribe to the GENES-R-US genetic counseling service. (
  • Some possible genetic contributions include the role of polymorphisms in genes associated with serotonin, noradrenalin, and dopamine neurotransmission, such as variants of the.serotonin transporter genes which inhibit serotonin reuptake, leading to insufficiency of monoamines in the brain and thus predisposing to depression. (
  • Genes that regulate the circadian rhythm are another potential cause of genetic predisposition to depression by interfering with normal sleep and other body functions that depend on the circadian pacemaker. (
  • The transfer of genetic material between non-mating species, known as horizontal gene transfer (HGT), has attracted growing attention as a powerful mechanism for genetic evolution. (
  • GENE-TOX provides genetic toxicology (mutagenicity) test data from expert peer review of open scientific literature for more than 3,000 chemicals from the United States Environmental Protection Agency (EPA). (
  • Rather, a particular genetic variant interacts with many external influences to produce cancer more often than in people with different variants of the gene. (
  • The encoding of multiple peptides in a single mono- cistronic mRNA appears to be a genetic mechanism for the gener- ation of biologic diversification without requiring amplification of gene sequences. (
  • In order for each cell to know what to do during development, it follows a genetic blueprint, which consists of complex webs of interacting genes called gene regulatory networks. (
  • The model is also a powerful tool for understanding gene regulatory networks in a way not previously possible, allowing scientists to better study the genetic bases of both development and evolution. (
  • By comparing the gene regulatory networks of different species, biologists can probe how they branched off from common ancestors at the genetic level. (
  • Yet genetic experiments in lower organisms and our own centenarian pedigree data indicate that at least a few genes may exist that exert a powerful influence upon longevity. (
  • It describes the frontier of research-the use of synthetic genes to "protect against disease," while changing the genetic makeup of humans. (
  • Based on the trends they saw, the group concluded there were racial differences at the genetic level - despite lack of any data on genes. (
  • While 95 percent of dogs sampled had coats that could be explained by the three genes, a few breeds showed that they must be getting some genetic information from elsewhere, so researchers still have a little work to do to explain dogs completely. (
  • Each person has thousands of genes -- billions of base pairs of DNA or bits of information repeated in the nuclei of human cells --which determine individual characteristics (genetic traits). (
  • Scientists from University College London studied 359 men who either had two copies of the high-risk gene, or two copies of a genetic variant thought to cause low risk of obesity. (
  • When bodies appear to be acting altruistically, what's actually happening is that "selfish" genes within those seeming altruists are benefiting identical copies of themselves in other bodies, often genetic relatives. (
  • To see whether that duplication formed the genetic origin of intelligence in vertebrates, Grant's team subjected mice with different mutations in these genes to a battery of visual tests that assess learning and attention in changing environments. (
  • The presence of the gene variant was checked easily with a genetic cheek swab, Cramer says. (
  • In addition to sequencing the DNA of a number of lower research organisms, they are rapidly identifying unique genetic markers along the entire length of human DNA--the equivalent of mile markers along a highway--which facilitate the discovery of interesting new genes, including those associated with elusive human diseases. (
  • Using a series of elegant experiments, Mendel formulated a theory that genetic traits were passed unchanged from one generation to the next in units he named Merkmales (now called genes), and that each plant's characteristics depended on the interaction of two of these Merkmales , one inherited from each parent. (
  • Utilizing bioinformatic databases - which contain an abundance of information related to various genes and their genetic associations - the UA researchers first mined the data, prioritizing 867 genes for testing. (
  • Global Genes is a global non-profit advocacy organization for individuals and families fighting rare and genetic diseases. (
  • The organization is associated with a blue denim "Genes Ribbon" that is intended to raise awareness of patients affected by rare and genetic diseases. (
  • More than 150 PSEN1 gene mutations have been identified in patients with early-onset Alzheimer disease, a degenerative brain condition that begins before age 65. (
  • Mutations in the PSEN1 gene are the most common cause of early-onset Alzheimer disease, accounting for up to 70 percent of cases. (
  • Almost all PSEN1 gene mutations change single building blocks of DNA (nucleotides) in a particular segment of the PSEN1 gene. (
  • Studies suggest that the PSEN1 gene mutation that causes hidradenitis suppurativa has a different effect on γ-secretase function than the mutations that cause early-onset Alzheimer disease. (
  • It does not allow anyone to patent my own specific BRCA1 gene, but it allowed Myriad to patent the sequence of the gene with mutations that indicate breast cancer-which can then be compared with another patient's version of the gene to see if she carries the mutation pattern. (
  • This classification applies to gene mutations as well. (
  • To create the map, the scientists sequenced protein-coding genes in seven oligodendroglioma tissue samples, and focused attention on recurring mutations in two genes not previously associated with these tumors "" CIC and FUBP1. (
  • More mutations in the two genes were found in an additional 27 oligodendroglioma samples. (
  • In the current study, the Johns Hopkins investigators found mutations in the remaining copies of the CIC and FUBP1 genes on chromosomes 1 and 19, suggesting that these mutations represent the second hit needed to create cancer. (
  • Variations or mutations within a gene may themselves act to cause the disease. (
  • The study showed that changes, or mutations, in these genes lead to learning problems in both mice and humans, as well as psychological disorders in humans, said Jeffrey Boore, the CEO of Genome Project Solutions, who was not involved in the study. (
  • But if there are two copies of a gene, then the animal has a spare functioning copy, which allows those genes to rack up more mutations - both beneficial, harmful and neutral - without reducing survival fitness. (
  • Different mutations led mice to perform better or worse on cognitive tests, which implied that these genes play a key role in mouse intelligence. (
  • The most important thing they found was that many children with autism shared mutations in related genes. (
  • Their mutations affected different genes that all impacted the same or related biochemical pathways. (
  • AmbryGenetics, for example, a company offering an NGS-based test for mutations in 14 breast cancer related genes, specifically excludes BRCA 1 and 2. (
  • To understand the impact of the many different mutations in the BRCA genes researchers need to have access to a large patient population. (
  • The key innovation of our paper is that we actually resurrect Wrangel Island mammoth genes to test whether their mutations actually were damaging (most mutations don't actually do anything)," says lead author Vincent Lynch, PhD, an evolutionary biologist at the University at Buffalo. (
  • More than 70 mutations in the SGCA gene have been identified in people with limb-girdle muscular dystrophy type 2D. (
  • Forms of limb-girdle muscular dystrophy caused by gene mutations that affect the sarcoglycan complex are called sarcoglycanopathies. (
  • The rest of the known SGCA gene mutations are specific to individual families or certain populations. (
  • SGCA gene mutations may prevent the sarcoglycan complex from forming or from binding to and stabilizing the dystrophin complex. (
  • Since 2006, genome-wide association studies have found more than 50 genes associated with obesity, most with very small effects. (
  • By comparing some 500,000 of these common variations, a team of research groups discovered 24 genes and regions of the genome that raise a person's risk of developing diseases ranging from clinical depression to diabetes. (
  • An upper-limit estimate of a minimal bacterial gene set was obtained from the sequence of the entire Mycoplasma genitalium genome, which contains only ≈480 genes ( 1 ). (
  • More recently, an experimental approach involving high-density transposon mutagenesis of the H. influenzae genome led to a much higher estimate of ≈670 putative essential genes ( 3 ), whereas transposon mutagenesis of two mycoplasma species led to an estimate of 265-360 essential genes ( 4 ). (
  • Mount Sinai researchers and the Autism Genome Project Consortium (AGP) announced that they have identified new autism susceptibility genes that may lead to the development of new treatment approaches. (
  • The newly-discovered gene, which encodes a 448 amino acid protein with unknown function, occurs alongside nuclear genes in the Striga hermonthica genome, thus presenting the first clear case for nuclear HGT. (
  • Instead of studying diseases, as does the Human Genome Project , Bouchard and his colleagues at the Pennington Biomedical Research Center in Baton Rouge, Louisiana, gather information on fitness genes. (
  • By studying dogs' coats -- a trait easily observed by the human eye -- researchers wanted to better understand how the genes affected the coats, leading, they hope, to more specific findings in the genome later on. (
  • When the study authors sequenced the ancient fish's genome, they found that its genes have been evolving more slowly than the genes of the other fish or terrestrial vertebrates they looked at, including sharks, chickens, and lungfish. (
  • Our evidence shows unambiguously that these genome duplications and expansions in the gene family have produced greater complexity to the behavioral repertoire of the vertebrate," Grant said. (
  • This had previously been a difficult thing to achieve, given that the chloroplast genome contains numerous genes which are essential for survival. (
  • With personalized medicine on the rise and many people interested in having their genome sequenced restricting who can look at a particular gene makes little sense and the much coveted $1000 genome will hopefully not be rendered ineffective by patent laws. (
  • So far, rare variants in at least nine genes have been implicated in single-gene (monogenic) obesity. (
  • Several of these genes also have variants that are associated with monogenic obesity, a phenomenon that has been observed in many other common conditions. (
  • Some genes with variants that have been associated with obesity are listed in the Table . (
  • Gene variants generally considered misfortunes (poor Jim, he got the "bad" gene) can instead now be understood as highly leveraged evolutionary bets, with both high risks and high potential rewards: gambles that help create a diversified-portfolio approach to survival, with selection favoring parents who happen to invest in both dandelions and orchids. (
  • If variants of certain genes create mainly dysfunction and trouble, how have they survived natural selection? (
  • For more than a decade, proponents of the vulnerability hypothesis have argued that certain gene variants underlie some of humankind's most grievous problems: despair, alienation, cruelties both petty and epic. (
  • The authors examined all of the 37 variants (in 8 separate genes) previously reported to have an association with eye colour in a sample of 6,168 Dutch of European ancestry, and assessed the predictive value of these markers alone and in combination. (
  • Adding further markers had rapidly diminishing returns, with the last 15 markers adding essentially nothing further in terms of predictive value (these markers were typically captured by other variants within the same gene). (
  • Findings show that the DNA of individuals with ASDs has more copy number variants (CNVs) - rare submicroscopic insertions and deletions - disrupting genes, including genes previously reported to be associated with autism, but also other genes such as those involved in intellectual disabilities. (
  • In an update, the scientists identified 102 gene variants and 269 genes associated with depression. (
  • Do black people carry certain gene variants that give them weaker hearts? (
  • Now, Deborah Waber, Ph.D, and colleagues at Boston Children's Hospital, Massachusetts, U.S., have found four specific gene variants that appear to raise the risk. (
  • This retrospective analysis tells us that going forward we may wish to examine children's genotypes at baseline and conduct prospective research to learn why these specific gene variants may increase risk of toxicity. (
  • These genes hang out all lined up on thread-like things called chromosomes (say: kro-moh-soamz). (
  • Most genes are contained in chromosomes . (
  • Most chromosomes contain many different genes. (
  • The theory is based on the fact that each cell in the human body has two copies of 23 chromosomes containing thousands of protein-producing genes. (
  • In oligodendrogliomas, the "first hit" has long been known to occur in regions of chromosome 1 and 19, which fuse together resulting in a loss of many genes on both chromosomes. (
  • Genes are arranged in precise arrays all along the length of 23 pairs of much larger structures: the chromosomes. (
  • Read what Steve the savvy scientist has to say about chromosomes and genes before testing your knowledge with some fill-in-the-blanks. (
  • They are found in clusters of Hox genes, strung together in a series on a chromosome. (
  • If a gene on one chromosome is damaged or deleted, the other copy makes up for the loss of protein. (
  • Additionally, because introns stay where the gene is physically located, fluorescently imaging introns allows researchers to visualize where genes are located within the chromosome, the large structure that DNA folds into within the cell's nucleus. (
  • In this work, the team was surprised to discover that most active, protein-encoding genes are located on the surface of the chromosome, not buried inside of it. (
  • The SGCA gene is found on chromosome 17 . (
  • All of the F 1 (first generation) offspring are heterozygous, meaning they contained both a dominant and recessive gene, RrYy, round and yellow. (
  • Sit down for a fun science lesson with Steve the savvy scientist as he teaches you all about dominant and recessive genes! (
  • They represent dominant and recessive genes. (
  • For a fun family activity to introduce your child to genetics, have your child go on a search for dominant and recessive family genes! (
  • In the new work, the researchers observed that special DNA-associated proteins called histones played a central role in whether gene expression increased in response to forces that stretched the cell. (
  • These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. (
  • Proneural genes encode a group of bHLH proteins that play crucial roles in controlling cell fate in a variety of tissue types. (
  • This implies that each of these proteins is capable of regulating both common target genes for neurogenesis and unique target genes for neuronal subtype characteristics. (
  • Studying these "epigenetic" effects involves measuring chemical modifications of DNA, RNA, or associated proteins that influence gene expression. (
  • Some genes stay active all the time to make proteins needed for basic cell functions. (
  • Grant and his colleagues wondered whether duplications of certain genes contributed to this explosion in the number of brain proteins, and as a result, to vertebrate intelligence. (
  • The findings suggest those first gene duplications probably also gave rise to rapid evolution in the nervous-system proteins that interact with the glutamate receptor, enabling vertebrates to have more subtle, sophisticated responses to their environment. (
  • Heterologous expression involves identification of genes and transfer of the corresponding DNA fragments to hosts other than the original source for synthesis of the encoded proteins. (
  • Then, they synthesized the altered genes, inserted that DNA into cells in petri dishes, and tested whether proteins expressed by the genes interacted normally with other genes or molecules. (
  • The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. (
  • A few--chiefly those with broad reservations about ever tying specific genes to specific behaviors--express concerns. (
  • As for the specific genes involved, another team previously found that a version of a gene encoding a receptor for the neurotransmitter dopamine is associated with age at first intercourse. (
  • We found that force can activate genes without intermediates, without enzymes or signaling molecules in the cytoplasm," said University of Illinois mechanical science and engineering professor Ning Wang, who led the research. (
  • The researchers found they could suppress or boost force-responsive gene expression by increasing or decreasing H3K9 histone methylation. (
  • At the highest frequencies, cells became stiffer and the enzymes that guide gene transcription could not bind to the DNA, the team found. (
  • By comparing the gene expression profiles of endothelial cells from regenerating liver to those derived from tumor-bearing livers, the researchers found 13 distinct genes that were selectively overexpressed (turned on to a greater degree than other genes) during disease-related angiogenesis. (
  • At least one mutation in the PSEN1 gene has been found to cause hidradenitis suppurativa, a chronic skin disease characterized by recurrent boil-like lumps (nodules) under the skin that develop in hair follicles. (
  • The Lund researchers found that the gene CXCR4 is essential for the leukemia stem cells' survival. (
  • the first homologue of the fly proneural genes to be found in mammals was mash1. (
  • For example, researchers probing type 1 diabetes report in Nature and Nature Genetics that they found seven new genes and regions associated with an elevated risk of developing the disease. (
  • 2003) examined the spatial and temporal pattern of 8 Hox genes in Euprymna and found a few things that were expected, and a few that were interestingly different. (
  • the ganglia that are at one end of the animal express the genes found at one end of the cluster, and the ganglia at the opposite end express genes found at the opposite end of the cluster. (
  • Most essential genes are present throughout a wide range of Bacteria, and almost 70% can also be found in Archaea and Eucarya. (
  • We found that some 25 percent of the genes in our model organism appear to be under clock control. (
  • The researchers studied the genes of more than 12,000 people and found that a gene variant may increase or lower the risk of a person developing gout. (
  • The gene variant in question is called SLC2A9, already known to scientists as a transporter of fructose, but in this new study, the researchers, led by Professor Alan Wright of the MRC Human Genetics Unit, found the variant also plays a key role in transporting uric acid. (
  • Wright and colleagues found that between 1.7 and 5.3 per cent of the variance in blood levels of uric acid was explained by the presence of this gene variant in a Croatian population sample, and that SLC2A9 was also linked with low levels of uric acid excretion and/or gout in population samples from the UK, Croatia and Germany. (
  • Another expert told BBC News there appears to be a link between this study and another one that suggested excessive drinking of sugary soft drinks also increased the risk of gout, since the gene variant that appears to control the ability of the body to remove uric acid from the blood is the same one that transports fructose, a sugar often found in soft drinks. (
  • The researchers found that a gene called alpha-actinin can make runners better at either sprinting or endurance, depending on which version of the gene they have. (
  • They found that sprinters tend to have one version of the gene, alpha-actinin-3 or ACTN3, while long-distance runners tend to have a different version, ACTN2. (
  • Neurogeneticist Kathryn North and her colleagues at the University of Sydney in Australia also found that more elite sprinters had not one but two copies of the alpha-actinin-3 gene. (
  • When two different alleles for the same trait are found in an organism, the gene that is expressed is the dominant allele , and the gene not expressed is the recessive allele . (
  • Findings published in the Proceedings of the National Academy of Sciences found that when 30 men made comprehensive lifestyle changes (such as improved nutrition, stress management techniques, walking, and psychosocial support), the new lifestyle actually changed the expression of more than 500 genes in only a 3-month period. (
  • Segal's team found that genes explain a third of the differences in participants' age at first intercourse - which was, on average, a little over 19 years old. (
  • Bo's lack of furnishings means that he has the ancestral form of that gene, matching the patterns found in wolves, according to the research. (
  • While the coat gene was initially found in Portuguese water dogs, researchers used genomes from 903 dogs in 80 different breeds to reach their overall conclusions. (
  • Obesity is in your genes, according to a study which found that one in six people inherits a trait which makes them feel less full after eating. (
  • Skin cells taken from the volunteers were cultured in the lab and injected with a bioluminescence gene found in fireflies. (
  • Several "brainy" genes that were duplicated in a tiny sea creature nearly 550 million years ago may have led to the massive expansion in intelligence in vertebrate species, two new studies have found. (
  • We found something similar and tested those predictions by resurrecting mutated genes in the lab. (
  • We've found five genes so far that significantly protect dopamine neurons from dying within our animal models," said Dr. Guy Caldwell, associate professor of biological sciences at UA and co-author of the research. (
  • In June 2017 Twist Bioscience and the BioBricks Foundation announced a First-of-its-Kind partnership to provide 10,000 genes to the synthetic biology community (1). (
  • Under the terms of the agreement, the BioBricks Foundation (BBF) will pay for synthesis of 10,000 genes from Twist Bioscience. (
  • The aim is to enable a distributed community of people to collectively propose and prioritize 10,000 genes for ab initio DNA synthesis. (
  • This work builds off of previous advances from the Cai laboratory, including an earlier version of seqFISH from 2014 and research from 2017 that profiled over 10,000 genes under a microscope. (
  • Scaling seqFISH up to a genomic level now enables the imaging of over 10,000 genes--about half of the total number of genes in mammals--within single cells. (
  • The identified mutation deletes a single DNA building block (nucleotide) from the PSEN1 gene, written as 725delC. (
  • These differences may explain why no single PSEN1 gene mutation has been reported to cause the signs and symptoms of both diseases. (
  • The breast cancer gene mutation, for example, doesn't cause breast cancer. (
  • If you only need to inherit one copy of a gene mutation to get a disease or syndrome, it is called dominant. (
  • People with a mutation in a gene known as FTO have higher levels of a "hunger hormone" in their blood which make them feel hungry again shortly after eating. (
  • Normally, if a mutation crops up in a gene that's critical to an animal's survival, evolution will weed out that animal, which usually means very little change occurs in critical genes. (
  • Moreover, the team showed humans and mice carrying the same mutation in a specific glutamate-transporting gene have reduced adaptive learning, suggesting these genes control intelligence and learning across vertebrate species. (
  • In humans, this gene mutation is linked to schizophrenia . (
  • The most common SGCA gene mutation occurs in about one-third of people with limb-girdle muscular dystrophy type 2D. (
  • However, essential genes related to cell envelope, shape, division, and respiration tend to be lost from bacteria with small genomes. (
  • A computational approach, based on the assumption that essential genes are conserved in the genomes of M. genitalium and Haemophilus influenzae , led to a description of a smaller set of some 260 genes ( 2 ). (
  • and doctoral student Erfan Mohagheghian discovered that mechanical forces on cells can boost gene expression in the nucleus. (
  • Cells will ramp up gene expression in response to physical forces alone, a new study finds. (
  • Previous studies revealed that some genes are susceptible to physical manipulations of cells, but Wang and his colleagues were the first to show that stretching cells alone could influence how such genes are expressed. (
  • The team first demonstrated this phenomenon with genes they had inserted in cells. (
  • In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo retroviral transduction of surgically harvested cells. (
  • Now, a research team at Lund University in Sweden has identified one of the genes that is the basis for leukemia stem cells' survival and multiplication. (
  • It is the leukemia stem cells in the bone marrow that drive the disease forwards and that is why we want to investigate which genes control these stem cells. (
  • When they cut off this gene, the leukemia stem cells could not survive, as they are totally dependent on the protein that the gene produces. (
  • Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor cells. (
  • From the same ectodermal cell types, neural or epidermal cells can develop based on interactions between proneural and neurogenic genes. (
  • On the other hand, proneural genes mutants fail to develop neural precursor cells. (
  • The proneural genes are expressed in groups of cells (proneural clusters) from which one progenitor cell - typically the one in the middle - will be singled out, leading to the formation of many different types of neurons in the central and peripheral nervous systems. (
  • The cells within a cluster that express a proneural gene (called a proneural cluster) can be thought of as cells of an equivalence group. (
  • In neuroectoderm, neurogenic genes are required to single out cells from within proneural clusters to form neuronal precursors, leaving the remaining cells of proneural clusters to develop into epidermal cells. (
  • The entry for ADHD is representative and includes brief videos with scientists (transcripts are included), print material, and graphics under subheadings: genes, biochemicals, cells, brain anatomy, cognition, and environment explaining each factor's role in ADHD. (
  • Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. (
  • This allows the expression of genes to be finely tuned to the variable microenvironments of cells. (
  • Dexter's team will insert good copies of the gene into bone marrow cells extracted from the patients. (
  • The aim is to get the gene into stem cells-primitive, undifferentiated cells which mature into white blood cells. (
  • This model, the scientists say, does a remarkably good job of calculating what these networks do to control the fates of different cells in the early stages of sea-urchin development-confirming that the interactions among a few dozen genes suffice to tell an embryo how to start the development of different body parts in their respective spatial locations. (
  • The model encompasses the gene regulatory network that controls the first 30 hours of the development of endomesoderm cells, which eventually form the embryo's gut, skeleton, muscles, and immune system. (
  • In other words, the researchers represented the network as a series of if-then statements that determine whether certain genes in different cells are on or off (i.e., if gene A is on, then genes B and C will turn off). (
  • All the cells in the body (except egg and sperm) contain the same genes. (
  • Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells. (
  • The viruses invade human cells with their DNA payloads, and the synthetic gene is incorporated into the recipient's own DNA. (
  • If all goes well, the new genes instruct the cells to begin manufacturing powerful antibodies. (
  • A breakthrough new technique enables scientists to image 10,421 genes at once within individual cells. (
  • Previously, researchers could only image four to five genes at a time in cells with microscopy. (
  • Seeing introns reveals which genes are currently turned on in individual cells, how strongly they are expressed, and where they are located. (
  • Those genes, which code for the receptor that binds glutamate and the cellular components that process it inside brain cells, were first duplicated in a 2-inch-long (5 centimeters), sea-faring worm called a pikaia that gave rise to all vertebrate species about 550 million yeas ago. (
  • The present review covers the recent literature on plant gene expression in bacteria, yeast, insect cells and Xenopus oocytes and presents the comparative advantages and disadvantages of each system. (
  • So we can resurrect the mammoth version, make cells in culture produce the mammoth gene, and then test whether the protein functions normally in cells. (
  • For example, the gene for brown eyes is dominant while the gene for blue eyes is recessive, so if you get one copy of the brown eye gene from one parent and a copy of the blue eye gene from the other, you will have brown eyes. (
  • They are grouped in distinct families on the basis of closer sequence similarities in the bHLH domain: Genes of the ASC and Ngn families, and possibly members of the family of ato homologues, have a similar proneural function in vertebrates to that of their Drosophila counterparts, whereas other neural bHLH genes are involved in specifying neuronal fates or in neuronal differentiation, but have no proneural role. (
  • Proneural genes may function in analogous fashions in vertebrates and invertebrates, specifically they were implicated in early neurogenesis. (
  • In vertebrates, these genes get activated at that roughly defined period, the phylotypic stage, and are key players in organizing the animal's properties along its length. (
  • Hox gene expression is also associated with segmental organization in arthropods and vertebrates. (
  • The studies, published today (Dec. 2) in the journal Nature Neuroscience, suggest this duplication of certain genes spurred an explosion in the number of chemicals that regulate brain function in vertebrates (animals with backbones), thereby leading to greater intelligence , the research suggests. (
  • In particular, the researchers noticed that vertebrates had multiple copies of two genes that process glutamate , a brain chemical critical for learning and memory. (
  • Only 4% of essential genes encode unknown functions. (
  • Their expression pattern is collinear, that is, the order of genes in the cluster reflects the temporal and spatial sequence of gene activation in the organism. (
  • Among ≈4,100 genes of the organism, only 192 were shown to be indispensable by this or previous work. (
  • Finally, the use of antisense RNA is limited to the genes for which an adequate expression of the inhibitory RNA can be obtained in the organism under study. (
  • Likewise, if an organism is true-breeding , both genes that control the same trait had to be the same gene ( homozygous ). (
  • This network-so far the most extensively analyzed developmental gene regulatory network of any animal organism-consists of about 50 regulatory genes that turn one another on and off. (
  • This singling out process is mediated by cell-cell interactions interpreted through the action of neurogenic genes. (
  • Most obesity seems to be multifactorial, that is, the result of complex interactions among many genes and environmental factors. (
  • It guarantees your uniqueness, for sure, but what that uniqueness will actually turn out to be is up to an infinitely complex set of gene-environment interactions influenced by nutrition, environment, culture, human whim, and many unknowns. (
  • And underlying all these processes and their intricate interactions are the genes that govern their function. (
  • Proneural bHLH transcription factors, not only drive neurogenesis by activating the expression of a cascade of neuronal genes, but they inhibit the expression of glial genes. (
  • Drawing on work from artificial intelligence and philosophy of mind, he argues that the key lies in how multiple transcription factors combine to regulate a single gene, acting in a way that is qualitatively consistent. (
  • The rice plastid genes psaA and psaB encoding the two apoproteins ofP700 chlorophyll a protein complex of photosystem I reac-tion center, and the putative rpsl4 gene for ribosomal protein Sl4, are organized into a transcription u it. (
  • In the absence of demonstrated function a gene may be characterized by sequence, transcription or homology. (
  • The team chose to focus on labeling introns because they are produced so early in the transcription process, giving a picture of what a cell is doing at the precise moment of gene expression. (
  • This led them to discover that the transcription of genes oscillates globally across many genes on what Cai calls a "surprisingly short" timescale--only about two hours--compared to the time it takes for a cell to divide and replicate itself, which takes from 12 to 24 hours. (
  • Our molecular clock and circadian rhythm is affected by clock genes and their transcription factors. (
  • The findings, published in the Journal of Clinical Investigation , could explain why people with the high-risk variant of the FTO gene have larger appetites and eat higher-calorie foods, as shown in previous research. (
  • Despite the significant findings, Cole adds that further work must be done to confirm the role of the four genes. (
  • The dance school was a great success, but Gene was not content being a teacher. (
  • In this analysis, they looked to see whether the particular gene sequences they had identified were associated with Crohn's in the new groups of people. (
  • They can be fused to regulatory sequences or genes of interest to report expression location or levels. (
  • In addition to provid- ing the coding sequences of recognized hormonal and regulatory peptides, gene sequencing has uncovered new bioactive peptides encoded in the precursor pro hormones that are then liberated along with the hormonal peptides during cellular cleavages of the precursors. (
  • The purpose of this document is to provide guidance for the preparation of sequences for submission to the Bionet 10k Genes Project. (
  • Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. (
  • A study led by a team of scientists in Scotland suggests that genes may play a part in increasing one's risk of developing gout , a painful condition that affects the joints. (
  • This suggests that genes have a very strong effect in autism. (
  • The project has already accelerated the identification of genes associated with human diseases and the development of new drugs to treat them. (
  • The new method using gene scissors means that the researchers can effectively control which gene is turned off, making it possible to study the gene's function and thus better understand how diseases arise. (
  • In 2018, AbbVie paid Voyager $69 million to develop gene therapies for the treatment of Alzheimer's and other diseases linked to defective or excess aggregation of tau protein. (
  • That is because genes, although potent predictors, are not always the sole cause of particular diseases. (
  • Nevertheless, on average, having one copy of some of the newly identified genes raises a person's chances of developing one of the seven studied diseases by 20 to 40 percent, and those with two copies face nearly double that risk, researchers say. (
  • The same genes that play key roles in sports performance also sometimes figure in common chronic problems such as cardiovascular diseases, diabetes, osteoporosis, obesity and others. (
  • In recent years, the U.S. Patent and Trademark Office has allowed about 20 percent of human genes to be patented, including those associated with common diseases such as Alzheimer's, asthma, and colon cancer. (
  • The diseases also have complex causes, which include many different genes and environmental factors. (
  • Scientists isolate the genes that produce powerful antibodies against certain diseases and then synthesize artificial versions. (
  • They get all the same diseases humans do and the same genes are likely to be involved. (
  • The process of identifying these genes, called disease gene discovery, is important because it helps scientists to understand what is going wrong as a result of such diseases, called the disease pathogenesis. (
  • Other articles examine crucial applied questions, such as how genes influence autoimmune thyroid diseases, or which chickens are the most resistant to colonization by Campylobacter jejuni , one of the most common causes of food-borne illness in humans. (
  • The flip side of plasticity is stability, Cramer explains, and with some brain conditions, such as Parkinson's disease and other neurodegenerative diseases, the bad-driving gene gives stability to the brain, meaning it might slow the progression of the degenerative disease. (
  • In a possible first step toward a far-off day when mosquitoes would be rendered incapable of carrying diseases like malaria, scientists at Colorado State University have inserted foreign genes into mosquitoes. (
  • By employing special gene scissors, CRISPR, we have been able, using an animal model, to study around 100 genes at the same time. (
  • The techniques both build on the discovery of CRISPR, a bacterial immune system that biologists have hacked into a gene-editing tool. (
  • Rarely, obesity occurs in families according to a clear inheritance pattern caused by changes in a single gene. (
  • Proneural genes promote neurogenesis and inhibit gliogenesis but some neurogenic factors can regulate both of these processes, depending on the proneural genes concentration. (
  • Another experimental approach using antisense RNA to inhibit gene expression led to the identification of some 150 essential genes in Staphylococcus aureus ( 5 ). (
  • Please remember that as of this writing (November 2017) the 10K Genes Project is still in its beta phase, and so there may be significant lag time for your samples. (
  • Researchers have discovered five genes that convey protective capabilities against a hallmark trait of Parkinson's disease. (
  • Foreign genes have another advantage in the chloroplasts besides this: they are inherited almost without exception through the female egg cell. (
  • It is therefore extremely rare for foreign genes to spread through the pollen of the tobacco plants. (
  • To pull off something like this, various genes are going to need to fire off at the right time in the right order. (
  • They are all regulatory genes that bind DNA to switch other genes off and on. (
  • This image of a sea-urchin embryo shows where two different regulatory genes are being expressed, labeled in fluorescent green and red. (
  • Despite the impact of these biological processes in circadian rhythm and possible effect on circadian control, the clock gene did not seem to be diurnally regulated in peripheral tissues. (
  • Using large-scale gene analysis, they combed 17,000 genes of the parasite witchweed Striga hermonthica, a source of devastating damage to sorghum and rice crops in Africa, for traces of transfer from host species. (
  • Topics include DNA methylation, histone modifications, chromatin modifications, the role of epigenetic modifications and environment on gene expression, and integrating genomic medicine into clinical practice. (
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (
  • Vaccines can be used as a cover for the injections of any and all genes, whose actual purpose is re-engineering humans in far-reaching ways. (
  • We have 2 versions (copies) of most genes - one from each parent. (
  • You will only get blue eyes if you get 2 copies of the blue eye gene (one from each parent). (
  • Environmental exposures during critical periods of human development can cause permanent changes in a gene's activity without changing the sequence of the gene itself. (
  • Certain Hox genes get reactivated later in development and turned on in a predictable sequence along the length of the limb, for instance, to define the proximo-distal organization of your legs and arms. (
  • By computing the results of each sequence hour by hour, the model determines when and where in the embryo each gene is on and off. (
  • Each gene is made up of a specific DNA sequence that contains the code (the instructions) to make a certain protein, each of which has a specific job or function in the body. (
  • A gene is a sequence (a string) of bases. (
  • The first gene patent was granted in 1982 for the sequence encoding insulin. (
  • The gene/protein must be the main focus of the article. (
  • Polymorphisms of clock genes, at least within animal models, can lead to impaired glucose tolerance and insulin resistance and contribute to obesity and perturbate fatty acid metabolism (Garaulet, M. et al. (
  • Working with partner Neurocrine Biosciences, Voyager is testing a gene therapy designed to enable Parkinson's patients to convert levodopa into dopamine. (
  • The UA researchers' efforts, Caldwell said, represents one of the largest functional analyses of genes ever reported for Parkinson's disease. (
  • Another explanation is variation in genes that regulate the functioning of the hypothalamopituitary adrenal (HPA) axis that is activated with stress, for instance. (
  • Another possibility is polymorphism in genes that regulate the development of the nervous system leading to fewer neurons in the adult brain. (
  • Two obvious questions are: 1) Does the fed-fasting state at mealtime modulate gene expression and regulate energy expenditure? (
  • The current study finds that naturally occurring genes can also be activated by stretching. (
  • Molluscs are particularly interesting subjects for study of Hox gene expression for a couple of reasons. (
  • Molecular evolutionary study of the genes causing reproductive isolation may represent an important new phase in the study of speciation. (
  • The study behind this story provides good evidence that there are a large number of genes that can increase a person's susceptibility to Crohn's disease. (
  • In the study, published in Nature Genetics , researchers compared the genes of 5,586 women with endometriosis to 9,331 women without endometriosis. (
  • The current study looked at whether coffee intake is associated with breast volume, and how this is modified by which variant of the gene CYP1A2*1F a woman carries. (
  • This was a cross-sectional study in which the authors aimed to investigate whether coffee intake was associated with breast volume and how this was modified by a particular variant of gene CYP1A2*1F (the A/A genotype). (
  • A University of Edinburgh study has shown that genes play a major role in depression. (
  • But in a classic study, John Alford, a political scientist at Rice University, showed that identical twins, who share all the same genes, are more likely to share political views than fraternal twins, who share only about 50 percent of their genes. (
  • Interestingly enough, this isn't the first study to find that healthy lifestyle changes can fire up those lean genes. (
  • Instead, these improved habits change the expression of the genes, says Dean Ornish, M.D., lead study author and founder and president of the nonprofit Preventive Medicine Research Institute in Sausalito, California. (
  • It's not like there's a gene for having a sex at a certain date," says Nancy Segal , a psychologist at California State University in Fullerton who led the new study. (
  • Fretwell, who was not involved with the research, said that the results of the study match expectations, in that three genes had a large impact. (
  • Dr Rachel Batterham, who led the study, explained: ""We've known for a while that variations in the FTO gene are strongly linked with obesity, but until now we didn't know why. (
  • In the deep sea, slow and steady wins the race-and that proverb is reflected in the genes of the coelacanth ( Latimeria chalumnae ), a new study says. (
  • Which type of seizures to study depends mostly on how important genes are for that particular type of disease. (
  • One important type of population study looks at a large set of twins to see how often two identical twins (who have all the same genes) both have a disease and compares that to how often two fraternal twins (who are just like brothers and sisters in that they have only half of their genes in common) both have the disease. (
  • Study and categorize the functions and types of genes. (
  • A recent study among Hispanic children indicated that variations in the MC4R gene may have a significant function in regulating weight through energy intake and expenditure (Cole, S.A. et al. (
  • To assess the value of this time component, a 40-person Icelandic study evaluated blood samples for more than 23,000 transcripts corresponding to more than 20,000 genes. (
  • Typically, blood glucose is measured in the fasting state, whereas in this study, there was a better relationship between gene expression traits and blood glucose in response to feeding. (
  • The goal of the project was to study whether the genes functioned normally. (
  • According to a study published in the journal Cerebral Cortex, a certain common gene variation restricts the release of a protein called brain-derived neurotrophic factor (BDNF) that in turn affects the brain's ability and rate of learning complicated tasks. (
  • As many as 30 percent of Americans carry this gene variation, says Dr. Steven Cramer, lead author of the study and an associate professor of neurology at the University of California at Irvine. (
  • So, not surprisingly, the lack of brain fertilizer (in people with the gene variant) affects not only driving, but also other complex tasks, Cramer says, adding that he chose to study driving ability because it's a very common, complex task. (
  • A prospective study, in which patients' genes are tested in advance of treatment, would provide more reliable evidence. (
  • Other genes are also being studied, and some think that depression occurs across a wide spectrum of severity, various forms being only different subtypes of the same disease. (
  • Roughly 170 of these genes representing common characteristics of slightly more than 11,000 time-related metabolic traits had an overlap with several categories, such as wound healing, inflammation, protein kinase cascade, and regulation of signal transduction. (
  • Genes, Brain and Behavior (also known as G2B) is a peer-reviewed online-only scientific journal covering research in the fields of behavioral, neural, and psychiatric genetics. (
  • Genes, Brain and Behavior is published by Wiley-Blackwell on behalf of the International Behavioural and Neural Genetics Society. (
  • In its third year, Genes, Brain and Behavior was available in 1400 academic libraries. (
  • The five journals that as of 2016[update] have cited Genes, Brain and Behavior most often, are (in order of descending citation frequency) PLoS ONE, Genes, Brain and Behavior, Scientific Reports, Neuroscience & Biobehavioral Reviews, and Behavioural Brain Research. (
  • As of 2016[update], the five journals that have been cited most frequently by articles published in Genes, Brain and Behavior are The Journal of Neuroscience, Proceedings of the National Academy of Sciences, Nature, Science, and Neuron. (
  • But that doesn't mean their genes give them better skin - it's due to their behavior. (
  • That supports the notion that these genes "have diversified throughout evolution from their ancient duplications to perform important, specific, diverse roles in mammal cognition in behavior. (
  • Genes to Cognition presents supporting information for grades 9-12 on cognitive disorders, cognitive processes, and research approaches in brain studies. (
  • It may be that this gene has a greater time-dependent impact on other tissues, including the brain (Leonardson, A.S., 2009). (
  • In other words, people without this particular "bad-driving gene" variant have more access to brain fertilizer. (
  • Some children who are treated for acute lymphoblastic leukemia (ALL) develop brain impairments, and the risk of this happening may be linked to certain genes. (
  • carriers of the common FTO gene variant most consistently associated with obesity were able to reduce their risk through physical activity. (
  • Yet about a quarter of all human beings carry the best-documented gene variant for depression, while more than a fifth carry the variant that Bakermans-Kranenburg studied, which is associated with externalizing, antisocial, and violent behaviors, as well as ADHD, anxiety, and depression. (
  • The presence of the gene variant appears to impede the ability of the kidneys to filter uric acid from the bloodstream. (
  • The outcome: Subjects with the gene variant that restricts the protein BDNF performed 20 percent worse on the test. (
  • But it adds, tantalizingly, that these same troublesome genes play a critical role in our species' astounding success. (
  • Over the past few years, however, evolutionary geneticists have finally succeeded in isolating several such genes, providing our first glimpse at factors that are thought to be representative of those underlying the origin of species. (
  • Evolutionary analysis of these genes suggests that speciation results from positive Darwinian selection within species. (
  • A research team at RIKEN, Japan's flagship research organization, has uncovered the first ever evidence of nuclear gene transfer from host to parasite plant species. (
  • Studying gene regulatory networks with models may also offer new insights into the evolutionary origins of species. (
  • Furthermore, the short version of the gene, called the 'S allele', has been linked to a heightened risk of depression, especially if the person has been through adverse childhood events. (
  • Others have linked the same version of the gene - called DRD4 - to impulsive, risk-taking behaviour. (
  • Using molecular tools it was possible to isolate the first four genes of this complex: achaete (ac), scute (sc), lethal of scute (lsc) and asense (ase). (
  • Using Computing Life, the scientists were able to unravel how a network of genes and their products tell time, thereby demonstrating the solution of one of the key problems in systems biology. (
  • Now connectionist modeling returns to molecular biology to explain development via regulatory gene networks. (
  • Whenever we find genes mutated in a majority of tumors, it is likely that the pathway regulated by that gene is critical for the development and biology of the tumor," Nickolas Papadopoulos, Ph.D., associate professor of oncology at the Johns Hopkins Kimmel Cancer Center, was quoted as saying. (
  • Those genes will then be synthesized and be made available to the entire synthetic biology community under the Open Material Transfer Agreement (OpenMTA - see below). (
  • This book reviews the molecular biology of the gene in relation to aging. (
  • Genes and Aging is for all students and researchers interested in the molecular biology of aging. (
  • The so-called Manhattan Project of biology promises to reveal human disease genes and a host of other traits. (
  • Proneural genes have multiple functions in neural development. (
  • Neurogenic genes are so called because loss of function mutants show an increase number of developed neural precursors. (
  • Later on, in the 1970s, the achaete-scute complex, a complex of genes that are involved in regulating the early steps of neural development in Drosophila, were identified[by whom? (
  • Neural bHLH genes have different functions depending on: the sensitivity to lateral inhibition, which determines if a cell becomes epidermal or neuronal, and whether the gene is expressed in the CNS before or after the terminal mitosis. (
  • It is an exciting development to see Dr. Buxbaum and colleagues identify genes that have been linked to intellectual disabilities but not previously implicated in autism now be linked to that condition as well," commented Bruce D. Gelb, MD, Director of the Child Health and Development Institute at Mount Sinai. (
  • They were able to confirm that some previously identified genes were important in autism and they identified a few new ones. (
  • As if this wasn't complicated enough, autism is more than genes. (
  • Gene regulatory networks are so complex that it is almost impossible for a person to fully understand the role of each gene without the help of a computational model, which can reveal how the networks function in unprecedented detail. (
  • The scientists have identified at least 80 genes linked to depression. (
  • Now scientists have identified a specific gene that conceivably could push a runner over the line between good and great. (
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (
  • Feng Zhang of the Broad Institute of MIT participates in a panel discussion at the National Academy of Sciences international summit on the safety and ethics of human gene editing, Tuesday, Dec. 1, 2015, in Washington. (
  • A public resource model would also alleviate the unsettling prospect of something as fundamental as human DNA being owned by private entities-an idea that might not even make sense in the future, as the diagnosis of disease points toward a complicated interaction of genes and other factors. (
  • Each human cell has about 25,000 genes. (
  • The first human trial based on this strategy - called immunoprophylaxis by gene transfer, or I.G.T. - is underway, and several new ones are planned. (
  • The genes are placed into viruses and injected into human tissue, usually muscle. (
  • According to the official Guidelines for Human Gene Nomenclature, a gene is defined as "a DNA segment that contributes to phenotype/function. (