Mechanotransduction, Cellular: The process by which cells convert mechanical stimuli into a chemical response. It can occur in both cells specialized for sensing mechanical cues such as MECHANORECEPTORS, and in parenchymal cells whose primary function is not mechanosensory.Stress, Mechanical: A purely physical condition which exists within any material because of strain or deformation by external forces or by non-uniform thermal expansion; expressed quantitatively in units of force per unit area.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Gene Expression: The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.Biomechanical Phenomena: The properties, processes, and behavior of biological systems under the action of mechanical forces.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.North DakotaSouth DakotaFlowers: The reproductive organs of plants.Meristem: A group of plant cells that are capable of dividing infinitely and whose main function is the production of new growth at the growing tip of a root or stem. (From Concise Dictionary of Biology, 1990)Plants, Genetically Modified: PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.Genes, Plant: The functional hereditary units of PLANTS.Arabidopsis: A plant genus of the family BRASSICACEAE that contains ARABIDOPSIS PROTEINS and MADS DOMAIN PROTEINS. The species A. thaliana is used for experiments in classical plant genetics as well as molecular genetic studies in plant physiology, biochemistry, and development.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Sense Organs: Specialized organs adapted for the reception of stimuli by the NERVOUS SYSTEM.Helix-Loop-Helix Motifs: Recurring supersecondary structures characterized by 20 amino acids folding into two alpha helices connected by a non-helical "loop" segment. They are found in many sequence-specific DNA-BINDING PROTEINS and in CALCIUM-BINDING PROTEINS.Nervous System: The entire nerve apparatus, composed of a central part, the brain and spinal cord, and a peripheral part, the cranial and spinal nerves, autonomic ganglia, and plexuses. (Stedman, 26th ed)Gene Expression Regulation, Developmental: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.Drosophila: A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.Genetics: The branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance. (Stedman, 26th ed)Access to Information: Individual's rights to obtain and use information collected or generated by others.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Stem Cell Research: Experimentation on STEM CELLS and on the use of stem cells.Evolution, Molecular: The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.Science: The study of natural phenomena by observation, measurement, and experimentation.Microbiology: The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.NewsNewspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Epigenesis, Genetic: A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. Mechanisms involved cause heritable changes to cells without changes to DNA sequence such as DNA METHYLATION; HISTONE modification; DNA REPLICATION TIMING; NUCLEOSOME positioning; and heterochromatization which result in selective gene expression or repression.African Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Africa.European Continental Ancestry Group: Individuals whose ancestral origins are in the continent of Europe.Caribbean Region: The area that lies between continental North and South America and comprises the Caribbean Sea, the West Indies, and the adjacent mainland regions of southern Mexico, Central America, Colombia, and Venezuela.National Cancer Institute (U.S.): Component of the NATIONAL INSTITUTES OF HEALTH. Through basic and clinical biomedical research and training, it conducts and supports research with the objective of cancer prevention, early stage identification and elimination. This Institute was established in 1937.United StatesAfrican Americans: Persons living in the United States having origins in any of the black groups of Africa.Early Detection of Cancer: Methods to identify and characterize cancer in the early stages of disease and predict tumor behavior.Biological Clocks: The physiological mechanisms that govern the rhythmic occurrence of certain biochemical, physiological, and behavioral phenomena.CLOCK Proteins: Basic helix-loop-helix (bHLH) domain-containing proteins that contain intrinsic HISTONE ACETYLTRANSFERASE activity and play important roles in CIRCADIAN RHYTHM regulation. Clock proteins combine with Arntl proteins to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation. This transcriptional activation also sets into motion a time-dependent feedback loop which in turn down-regulates the expression of clock proteins.Circadian Rhythm: The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.Circadian Clocks: Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.ARNTL Transcription Factors: Basic helix-loop-helix (bHLH) domain-containing proteins that play important roles in CIRCADIAN RHYTHM regulation. They combine with CLOCK PROTEINS to form heterodimeric transcription factors that are specific for E-BOX ELEMENTS and stimulate the transcription of several E-box genes that are involved in cyclical regulation.Libraries: Collections of systematically acquired and organized information resources, and usually providing assistance to users. (ERIC Thesaurus, accessed 2/1/2008)Period Circadian Proteins: Circadian rhythm signaling proteins that influence circadian clock by interacting with other circadian regulatory proteins and transporting them into the CELL NUCLEUS.Endometriosis: A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.Polymorphism, Single Nucleotide: A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.Genetic Predisposition to Disease: A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.Genotype: The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.Genetic Variation: Genotypic differences observed among individuals in a population.Endometrium: The mucous membrane lining of the uterine cavity that is hormonally responsive during the MENSTRUAL CYCLE and PREGNANCY. The endometrium undergoes cyclic changes that characterize MENSTRUATION. After successful FERTILIZATION, it serves to sustain the developing embryo.Pelvic Pain: Pain in the pelvic region of genital and non-genital origin and of organic or psychogenic etiology. Frequent causes of pain are distension or contraction of hollow viscera, rapid stretching of the capsule of a solid organ, chemical irritation, tissue ischemia, and neuritis secondary to inflammatory, neoplastic, or fibrotic processes in adjacent organs. (Kase, Weingold & Gershenson: Principles and Practice of Clinical Gynecology, 2d ed, pp479-508)

Enzymes and reproduction in natural populations of Drosophila euronotus. (1/18964)

Populations of Drosophila euronotus, one from southern Louisiana )3 samples), and one from Missouri (2 samples), were classified for allele frequencies at alkaline phosphatase (APH) and acid phosphatase (ACPH) loci. The two populations differed consistently in allele frequencies at both loci. The APH locus is on the inversion-free X chromosome; the chromosomal locus of the autosomal ACPH is unknown, and could involve inversion polymorphism. Wild females from Missouri and Louisiana populations heterozygous at the APH locus carried more sperm at capture than did the corresponding homozygotes. This heterotic association was significant for the combined samples, and whether it was the result of heterosis at the enzyme locus studied, or due to geographically widespread close linkage with other heterotic loci, it should help to maintain heterozygosity at the APH locus. In a Louisiana collection which included large numbers of sperm-free females, simultaneous homozygosity at both enzyme loci was significantly associated with lack of sperm. It is suggested that the latter association is the result of young heterozygous females achieving sexual maturity earlier than do the double homozygotes. The average effective sperm load for 225 wild females was only 29.4, suggesting the necessity for frequent repeat-mating in nature to maintain female fertility. A comparison of the sex-linked APH genotypes of wild females with those of their daughters indicated that among 295 wild-inseminated females from five populations, 35% had mated more than once, and of this 35%, six females had mated at least three times. Because of ascertainment difficulties, it is clear that the true frequency of multiple-mating in nature must have been much higher than the observed 35%. Laboratory studies indicate that multiple-mating in this species does not involve sperm displacement, possibly due to the small number of sperms transmitted per mating, and the fact that the sperm receptacles are only partially filled by a given mating.  (+info)

Marker effects on reversion of T4rII mutants. (2/18964)

The frequencies of 2-aminopurine- and 5-bromouracil-induced A:T leads to G:C transitions were compared at nonsense sites throughout the rII region of bacteriophage T4. These frequencies are influenced both by adjacent base pairs within the nonsense codons and by extracodonic factors. Following 2AP treatment, they are high in amber (UAG) and lower in opal (UGA) codons than in allelic ochre (UAA) codons. In general, 5BU-induced transitions are more frequent in both amber and opal codons than in the allelic ochre codons. 2AP- and 5BU-induced transition frequencies in the first and third positions of opal codons are correlated with those in the corresponding positions of the allelic ochre codons. Similarly, the frequencies of 2AP-induced transition in the first and second positions of amber codons and their ochre alleles are correlated. However, there is little correlation between the frequencies of 5BU-induced transitions in the first and second positions of allelic amber and ochre codons.  (+info)

Mapping of the homothallic genes, HM alpha and HMa, in Saccharomyces yeasts. (3/18964)

Two of the three homothallic genes, HM alpha and HMa, showed direct linkage to the mating-type locus at approximately 73 and 98 strans (57 and 65 centimorgans [cM], respectively, whereas, the other, HO, showed no linkage to 25 standard markers distributed over 17 chromosomes including the mating-type locus. To determine whether the HM alpha and HMa loci located on the left or right side of the mating-type locus, equations for three factor analysis of three linked genes were derived. Tetrad data were collected and were compared with expected values by chi 2 statistics. Calculations indicated that the HM alpha gene is probably located on the right arm at 95 strans (65 cM) from the centromere and the HMa locus at approximately 90 strans (64 cM) on the left arm of chromosome III.  (+info)

Insect evolution: Redesigning the fruitfly. (4/18964)

Homeotic mutations in Drosophila can result in dramatic phenotypes that suggest the possibility for rapid morphological evolution, but dissection of the genetic pathway downstream of Ultrabithorax is beginning to reveal how wing morphology may have evolved by more gradual transformations.  (+info)

The Genexpress IMAGE knowledge base of the human brain transcriptome: a prototype integrated resource for functional and computational genomics. (5/18964)

Expression profiles of 5058 human gene transcripts represented by an array of 7451 clones from the first IMAGE Consortium cDNA library from infant brain have been collected by semiquantitative hybridization of the array with complex probes derived by reverse transcription of mRNA from brain and five other human tissues. Twenty-one percent of the clones corresponded to transcripts that could be classified in general categories of low, moderate, or high abundance. These expression profiles were integrated with cDNA clone and sequence clustering and gene mapping information from an upgraded version of the Genexpress Index. For seven gene transcripts found to be transcribed preferentially or specifically in brain, the expression profiles were confirmed by Northern blot analyses of mRNA from eight adult and four fetal tissues, and 15 distinct regions of brain. In four instances, further documentation of the sites of expression was obtained by in situ hybridization of rat-brain tissue sections. A systematic effort was undertaken to further integrate available cytogenetic, genetic, physical, and genic map informations through radiation-hybrid mapping to provide a unique validated map location for each of these genes in relation to the disease map. The resulting Genexpress IMAGE Knowledge Base is illustrated by five examples presented in the printed article with additional data available on a dedicated Web site at the address +/ welcome.html.  (+info)

Inhibition of cellular growth by increased guanine nucleotide pools. Characterization of an Escherichia coli mutant with a guanosine kinase that is insensitive to feedback inhibition by GTP. (6/18964)

In Escherichia coli the enzyme guanosine kinase phosphorylates guanosine to GMP, which is further phosphorylated to GDP and GTP by other enzymes. Here I report that guanosine kinase is subject to efficient feedback inhibition by the end product of the pathway, GTP, and that this regulation is abolished by a previously described mutation, gsk-3, in the structural gene for guanosine kinase (Hove-Jensen, B., and Nygaard, P. (1989) J. Gen. Microbiol. 135, 1263-1273). Consequently, the gsk-3 mutant strain was extremely sensitive to guanosine, which caused the guanine nucleotide pools to increase dramatically, thereby initiating a cascade of metabolic changes that eventually led to growth arrest. By isolation and characterization of guanosine-resistant derivatives of the gsk-3 mutant, some of the crucial steps in this deleterious cascade of events were found to include the following: first, conversion of GMP to adenine nucleotides via GMP reductase, encoded by the guaC gene; second, inhibition of phosphoribosylpyrophosphate synthetase by an adenine nucleotide, presumably ADP, causing starvation for histidine, tryptophan, and pyrimidines, all of which require PRPP for their synthesis; third, accumulation of the regulatory nucleotide guanosine 5',3'-bispyrophosphate (ppGpp), a general transcriptional inhibitor synthesized by the relA gene product in response to amino acid starvation.  (+info)

Linkage relations of locus for X-borne type of Charcot-Marie-Tooth muscular atrophy and that for Xg blood groups. (7/18964)

The locus for the X-borne type of Charcot-Marie-Tooth muscular atrophy is not close to the Xg locus and probably not within direct measurable distance of it.  (+info)

Two-gene control of the expression of a murine Ia antigen. (8/18964)

Two dimensional polyacrylamide gel electrophoresis of Non-Idet P-40 extracts and of specific Ia immunoprecipitates from [35S]methionine-labeled mouse spleen lymphocytes has revealed that the cell surface expression of some Ia antigens appears to be controlled by two genes. One locus, which maps in the I-A subregion, is probably the structural gene for an Ia polypeptide chain. The second locus, which maps between the I-J and H-2D regions, controls whether this I-A encoded molecule (Ae) remains in the cytoplasm or is modified and expressed on the cell surface. Complementation between these two loci allowing surface expression of Ae can occur in the cis or trans chromosomal position. Both the I-A molecule and a polypeptide chain coded for by a locus in I-E are coprecipitated by anti-I-E antibodies, suggesting that these two chains are associated with each other as a multisubunit complex in the cell. Because the ability to complement I-A for Ae expression is a property only of those strains which synthesize an I-E-encoded protein, it is likely that the I-E product itself is regulating the expression of Ae. These observations suggest several mechanisms by which interaction between two I region loci can generate new cell surface molecules. As a result, they may have important implications for understanding the molecular basis of two gene control of immune responsiveness and immune suppression.  (+info)

View Notes - Biology 1201 from BIOL 1201 at LSU. Eucaryotic Gene Regulation Genome Structure, Genes, DNA, and chromosomes Complete Genome DNA sequence know humans ,chimps ,flies ,worms, and plants…
Mouse Major Urinary Protein 3 products available through Novus Biologicals. Browse our Mouse Major Urinary Protein 3 product catalog backed by our Guarantee+.
Mutators can succeed: We have demonstrated that in continually changing environments where the adaptation to any given environmental state is independent of the adaptation to other states, mutator genes can climb to prominence by associated selection (i.e., by hitchhiking) with the linked beneficial mutations they generate. We have shown that even when mutators are extremely rare, there is a substantial probability that they will increase in frequency. We see this nonequilibrium analysis as a reminder that the average behavior of a process is sometimes an inadequate descriptor of the system as a whole. Although mutators are often lost in our model, in reality there would be recurrent mutation to the mutator state, and even if they are occasionally lost, organisms carrying a mutator gene would eventually dominate. "Eventually," however, could be a very long time so that we should be unsurprised to sometimes observe low mutator frequencies even in systems that do conform to the assumptions of our ...
Tetracycline-responsive transcriptional activator driven by the liver-specific mouse major urinary protein promoter (MUP-tTA).. The E. Coli tetracycline operon regulatory system was used to generate a liver-specific transcription activation system that was inhibited by tetracycline. The transcription activator was a fused protein consisting of a tetracycline repressor gene (tetR) that was only active in the presence of tetracycline and a herpes simplex virus protein (VP-16) transcription activating domain (Tet-Off). Transcription was induced only in the absence of tetracycline (Tet-Off). A liver-specific promoter such as the mouse major urinary protein (MUP) promoter determined that the tetracycline-regulated transcriptional activator (tTA) would be expressed specifically in liver. To study the effect of the transcription activator on a target gene (for example, beta-galactosidase, LacZ) specifically in liver, MUP-tTA mice would be mated with transgenic mice in which the TAg Target gene was ...
Complete information for LOC100420794 gene (Pseudogene), RE1 Silencing Transcription Factor Pseudogene, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Complete information for ATP6V0CP1 gene (Pseudogene), ATPase H+ Transporting V0 Subunit C Pseudogene 1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
Nick Cave and the Bad Seeds je australská rocková skupina, kterou v roce 1983 založili Nick Cave, Mick Harvey a Blixa Bargeld, přičemž v současné době ve skupině z původní sestavy působí pouze Cave. Skupina vydala celkem šestnáct studiových alb, poslední album pojmenované Skeleton Tree vyšlo v září 2016.[1] V roce 2017 vystoupila skupina v pražské O2 areně, vystoupení bylo hudebním webem iREPORT oceněno nejvyšším hodnocením. [2] ...
Publisher: PLOS (Public Library of Science). Date Issued: 2015-08-10. Abstract: BACKGROUND Automatically detecting gene/protein names in the literature and connecting them to databases records, also known as gene normalization, provides a means to structure the information buried in free-text literature. Gene normalization is critical for improving the coverage of annotation in the databases, and is an essential component of many text mining systems and database curation pipelines. METHODS In this manuscript, we describe a gene normalization system specifically tailored for plant species, called pGenN (pivot-based Gene Normalization). The system consists of three steps: dictionary-based gene mention detection, species assignment, and intra species normalization. We have developed new heuristics to improve each of these phases. RESULTS We evaluated the performance of pGenN on an in-house expertly annotated corpus consisting of 104 plant relevant abstracts. Our system achieved an F-value of ...
Using the dominant control region (DCR) sequences that flank the beta-globin gene locus, we have been able to achieve high-level expression of the human alpha-globin gene in transgenic mice. Expression in fetal liver and blood is copy number dependent and at levels comparable to that of the endogenous mouse alpha-globin genes. Transgenic fetuses with high-copy numbers of the transgene suffer severe anemia and die before birth. Using a construct with both the human alpha- and beta-globin genes and the beta-globin DCR, live mice with low-copy numbers were obtained. Both human globin genes are expressed at high levels in adult red cells to give human hemoglobin HbA in amounts equal to or greater than endogenous mouse hemoglobin. Expression of HbA in murine red cells is not accompanied by any increase in mean corpuscular volume (MCV) or mean corpuscular hemoglobin concentration (MCHC). However, these transgenic mice tend to have an increased number of reticulocytes in peripheral blood; consistent with some
Anthropogenetical Analysis of Abnormal Human -globin Gene Cluster Arrangement on Chromosome 16*. . Biblioteca virtual para leer y descargar libros, documentos, trabajos y tesis universitarias en PDF. Material universiario, documentación y tareas realizadas por universitarios en nuestra biblioteca. Para descargar gratis y para leer online.
το κείμενο με τίτλο GPSy: a cross-species gene prioritization system for ... - HAL σχετίζετε με Βιοτεχνολογία
[Molecular mechanisms of globin gene regulation and disregulation].: Human globin genes are expressed in tissue and developmental stage specific manners. Variou
Previous work has suggested that the promoter regions of the human embryonic zeta 2 and epsilon globin genes contain negative regulatory regions that could play a role in the repression of these genes in postembryonic erythroblasts. We have examined this possibility by studying the expression of these genes in mouse erythroleukemia cells, an adult erythroid cell line that might be expected to contain repressor molecules that would bind to the putative negative regulatory regions. When attached to appropriate upstream regulatory elements (alpha HS-40 and beta HS1,2) both the zeta and epsilon genes were expressed in these cells at a low level, but no increase in expression was observed when similar constructs lacking the proposed negative regulatory sequences were introduced into these cells. These results cast doubt on the possibility that these sequences play a major role in the developmental repression of the embryonic globin genes, unless they function only in a normal chromosomal organization.
Histones are the major protein component of nucleosomes, and de novo histone synthesis is essential for packaging newly replicated DNA into chromatin. As a result, histone gene expression is exquisitely and functionally coupled with DNA replication. Vastly divergent organisms such as yeast, fly and human all demonstrate the phylogenetically conserved propensity to maintain clustering of histone genes at one or more genomic loci. Although specific mechanisms are unclear, clustering is presumed to be important for common stringent transcriptional control of these genes at the G1/S phase transition. In this study, we describe a genomic duplication of the human histone gene cluster located at chromosome 1q21, which effectively doubles the previously known size and gene number of that cluster. The duplication persists in all examined tissues and cell lines, and the duplicated genes are transcriptionally active. Levels of messenger RNAs for duplicated histone H4 genes are high relative to those for non
TY - JOUR. T1 - Hpal polymorphic site 3 of the human β-globin gene is inside a repetitive sequence and cannot be ascertained by polymerase chain reaction. AU - Wang, X.. AU - Bouhassira, Eric E.. PY - 1992. Y1 - 1992. KW - Haplotype. KW - Kpnl sequence. KW - PCR. UR - UR - M3 - Article. VL - 39. SP - 226. EP - 227. JO - American Journal of Hematology. JF - American Journal of Hematology. SN - 0361-8609. IS - 3. ER - ...
A 2.4 kb region of theEuglena gracilis chloroplast genome containing the genespsbT, psbH andpsbN was characterized. The mRNAs transcribed frompsbB, psbT, p
Exon sequences are conserved, but intron sequences vary, Organization of Genetic Material Split Genes, Overlapping Genes and Pseudogenes, Genetics
Cosmid clones containing alpha 1-antitrypsin (alpha 1AT) gene sequences were observed to contain alpha 1AT-like sequences approximately 12 kb downstream of the authentic alpha 1AT gene. Restriction mapping suggested the alpha 1AT-like gene lacks promoter sequences. Cosmid clones from one library con …
Functional and pseudogenes are similarly organized and may equally contribute to the extensive antibody diversity of the IgVHII family.: Eleven germ-line immuno
... , Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
The International System for Human Gene Nomenclature (ISGN) was inaugurated in 1979, and has been continually updated. The Human Gene Mapping Nomenclature Committee, which developed the ISGN, put forth a
The International System for Human Gene Nomenclature (ISGN) was inaugurated in 1979, and has been continually updated. The Human Gene Mapping Nomenclature Committee, which developed the ISGN, put forth a
NSW has made several changes to COVID-19 control measures this week, with several restrictions eased and new rules put in... View Article. ...
Opgelet, omdat o.a. Joyce en Renate met een aantal projecten buiten Reincarnatus druk zijn de rest van het jaar, zal de concertagenda na 13 augustus een tijdje leeg blijven. Dus zorg dat je erbij bent 13 augustus in het openluchttheater Valkenburg!
Notice This is our old gene family archive which is no longer maintained. Please visit our new gene family pages for up to date family data.
This family contains the genes listed in PMID: 27991561 and 12 additional genes that may not meet the strict criteria laid out in that paper but have either been named for their WD repeat or acknowledged to contain one ...
Entries are submitted to the HuDSeN database using the official gene name, according to the HUGO Gene Nomenclature Committee, at the time of uploading. If an official gene name subsequently changes after submission of the entry to the database, the previous name may be shown in the table above ...
CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): There is presently disagreement between theory and experiment as well as between different theoretical calculations concerning the fine-structure splitting of the lowest P state of the neutral helium atom. We believe that we have found a minor error in the formulas used by Drake et al. (Can. J. Phys. 80, 1195 (2002)) in their calculations, and we may have an explanation how the error has occurred. To what extent this might resolve (part of) the discrepancy is not known at present. 1
mouse Cnih protein: Cnih - cornichon-like; member of the cornichon multigene family; C; involved in EGF signaling; RefSeq NM_009919
ATCC provides fully characterized strains necessary for the microbiological analysis of food products to identify and prevent the spread of foodborne disease.
Distribution of the mRNA/peptide in the cardiovascular system Southern blot analysis of human genomic DNA under low hybridization stringency with a 42-mer synthetic oligonucleotide probe corresponding to amino acid residues 7-20 of ET, showed that three different restriction fragments were always detected regardless of the restriction endonucleases used. The nucleotide sequences encoding amino acid residues of the three ETs are highly conserved among the three genes, with 77-82% of the nucleotide residues being identical [2]. By contrast, the nucleotide sequences upstream from the mature peptides are very poorly conserved. These observations suggest that although the three genes are evolutionally relatively distant from each other, the genes evolved from a common ancestral gene under strong pressure to preserve mature ET sequences. The three peptides were designated ET-1, ET-2 and ET-3 [5]. ET-1 is the original peptide corresponding to that detected in the culture medium of porcine aortic ...
A multiple catheter assembly (100) including a first catheter (110) constructed from a first material and having a first proximal end region (112), a first distal end region (114) terminating in a first distal tip (116), and an outer surface (120) defining at least a first lumen (122) extending longitudinally therethrough between a first distal (118) and a first proximal (111) opening. The first proximal end region (112) is integrally connected to an extension tube (320) constructed from a second material. A second catheter (130) is constructed from the first material and having a second proximal end region (132), a second distal end region (134) terminating in a second distal tip (136), and a second outer surface (140) defining at least a second lumen (142) extending longitudinally therethrough between a second distal (138) and a second proximal (131) opening. The second proximal end region (132) is integrally connected to an extension tube (350) constructed from the second material. The first lumen
We have cloned and characterized the Na,K-ATPase β3 subunit gene (ATP1B3), and a β3 subunit pseudogene (ATP1B3P1), from a human PAC genomic library. The β3 subunit gene is > 50 kb in size and is split
Bordelon, M R., "Malignant characteristics of somatic cell hybrids of normal human and malignant mouse cells. Abstr." (1974). Subject Strain Bibliography 1974. 446 ...
The Genetics Society of America (GSA), founded in 1931, is the professional membership organization for scientific researchers and educators in the field of genetics. Our members work to advance knowledge in the basic mechanisms of inheritance, from the molecular to the population level.. Online ISSN: 1943-2631. ...
Gentaur molecular products has all kinds of products like :search , Biolin \ Mouse Gene, RPL13A \ QT12X-MS-07 for more molecular products just contact us
Transcriptional correlations (ρpg:g) between pseudogenes and their parents.A) A heatmap for distribution of ρpg:g, including data from separation of processed
MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter.[5] Its official full name is meningioma ( ... in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8 ... in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11". Oncogene. 10 (8 ... "MN1 affects expression of genes involved in hematopoiesis and can enhance as well as inhibit RAR/RXR-induced gene expression". ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... Genes[edit]. Acne appears to be strongly inherited; genetics explain 81% of the variation in the population.[15] Studies ... among others.[19] The 308 G/A single nucleotide polymorphism variation in the gene for TNF is associated with an increased risk ... Acne susceptibility is likely due to the influence of multiple genes, as the disease does not follow a classic (Mendelian) ...
Genes[edit]. Number of genes[edit]. The following are some of the gene count estimates of human chromosome 16. Because ... Gene list[edit]. See also: Category:Genes on human chromosome 16.. The following is a partial list of genes on human chromosome ... So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[5] ... "HUGO Gene Nomenclature Committee. 2017-05-12. Retrieved 2017-05-19.. *^ "Chromosome 16: Chromosome summary - Homo sapiens". ...
This affects their function of gene regulation. In general, genes that are active have less bound histone, while inactive genes ... Repressed genes[edit]. Three histone modifications are particularly associated with repressed genes: Trimethylation of H3 ... Hannon Bozorgmehr J (Oct 2019). "The origin of chromosomal histones in a 30S ribosomal protein". Gene. doi:10.1016/j.gene. ... Histone gene transcription is controlled by multiple gene regulatory proteins such as transcription factors which bind to ...
Different genes on different loci would need to be selected for another fly species. The genes expressions are mapped in a ... the older the egg is the more of the particular gene is expressed.[33] However, all of the genes are expressed in varying ... Gene expression studies[edit]. Although physical characteristics and sizes at various instars have been used to estimate fly ... This is done by breaking the stages down into smaller units separated by predictable changed in gene expression.[33] Three ...
Genes[edit]. PEX genes encode the protein machinery ("peroxins") required for proper peroxisome assembly, as described above. ... Genes that encode peroxin proteins include: PEX1, PEX2 (PXMP3), PEX3, PEX5, PEX6, PEX7, PEX10, PEX11A, PEX11B, PEX11G, PEX12, ... doi:10.1016/j.gene.2009.09.014. PMID 19818387.. *^ Gabaldón T, Capella-Gutiérrez S (Oct 2010). "Lack of phylogenetic support ... for a supposed actinobacterial origin of peroxisomes". Gene. 465 (1-2): 61-5. doi:10.1016/j.gene.2010.06.004. PMID 20600706.. ...
Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor (BDNF), or abrineurin,[5] is a protein[6] that, in humans, is encoded by the BDNF gene.[7][8] ... Gene ontology. Molecular function. • receptor binding. • neurotrophin TRKB receptor binding. • growth factor activity. • GO: ... The BDNF protein is encoded by a gene that is also called BDNF, found in humans on chromosome 11.[7][8] Structurally, BDNF ...
Gene therapy[edit]. Gammaretroviral and lentiviral vectors for gene therapy have been developed that mediate stable genetic ... For example, the gag gene is translated into molecules of the capsid protein, the pol gene is translated into molecules of ... Rous sarcoma virus contains the src gene that triggers tumor formation. Later it was found that a similar gene in cells is ... transcribing and translating the viral genes along with the cell's own genes, producing the proteins required to assemble new ...
Gene[edit]. The human TNF gene (TNFA) was cloned in 1985.[22] It maps to chromosome 6p21.3, spans about 3 kilobases and ... Gene ontology. Molecular function. • transcription regulatory region DNA binding. • protein binding. • protease binding. • ... negative regulation of gene expression. • protein localization to plasma membrane. • positive regulation of protein catabolic ... positive regulation of gene expression. • extrinsic apoptotic signaling pathway. • extrinsic apoptotic signaling pathway via ...
Hallmarks include mutations to the alpha-synuclein gene, SNCA, as well as PARK2, PINK1, UCHL1, DJ1, and LRRK2 genes, and ... A gene called c9orf72 was found to have a hexanucleotide repeat in the non-coding region of the gene in association with ALS ... To date, multiple genes and proteins have been implicated in ALS. One of the common themes between many of these genes and ... Entrez Gene. "BDNF". United States National Center for Biotechnology Information.. *^ Kim J, Inoue K, Ishii J, Vanti WB, ...
In nature, such genes exist in several different forms and are therefore said to have multiple alleles. A gene with more than ... Traits controlled by two or more genes are said to be polygenic traits. Polygenic means "many genes." For example, at least ... An organism that has two identical alleles for a gene is said to be homozygous for that gene (and is called a homozygote). An ... Many other genes have multiple alleles, including the human genes for ABO blood type. ...
Gene[edit]. The AKR1B1 gene lies on the chromosome location of 7q33 and consists of 10 exons. There are a few putative ... Gene ontology. Molecular function. • aldo-keto reductase (NADP) activity. • electron carrier activity. • oxidoreductase ... Graham A, Brown L, Hedge PJ, Gammack AJ, Markham AF (April 1991). "Structure of the human aldose reductase gene". The Journal ... Graham A, Heath P, Morten JE, Markham AF (March 1991). "The human aldose reductase gene maps to chromosome region 7q35". Human ...
Kaplan AS, Levitan RD, Yilmaz Z, Davis C, Tharmalingam S, Kennedy JL (January 2008). "A DRD4/BDNF gene-gene interaction ... Brain-derived neurotrophic factor, also known as BDNF, is a protein[5] that, in humans, is encoded by the BDNF gene.[6][7] BDNF ... The BDNF protein is encoded by a gene that is also called BDNF, found in humans on chromosome 11.[6][7] Structurally, BDNF ... Common SNPs in BDNF gene[edit]. BDNF has several known single nucleotide polymorphisms (SNP), including, but not limited to, ...
Gene and regulation[edit]. P-selectin is located on chromosome 1q21-q24, spans , 50 kb and contains 17 exons in humans.[7] P- ... Gene ontology. Molecular function. • heparin binding. • oligosaccharide binding. • lipopolysaccharide binding. • calcium- ... P-selectin is a protein that in humans is encoded by the SELP gene.[5] ... Pan J, Xia L, McEver RP (April 1998). "Comparison of promoters for the murine and human P-selectin genes suggests species- ...
Gene and transcription[edit]. Obestatin is encoded by the same gene that encodes ghrelin, a peptide hormone. The mRNA produced ... Seim I, Amorim L, Walpole C, Carter S, Chopin LK, Herington AC (2010). "Ghrelin gene-related peptides: multifunctional ... removing the ghrelin gene from mice did not significantly reduce food intake. No secretory convertase is capable of cleaving ... a peptide encoded by the ghrelin gene, opposes ghrelin's effects on food intake". Science. 310 (5750): 996-9. doi:10.1126/ ...
Gene regulation[edit]. Main article: Regulation of gene expression. At the cellular level, homeostasis is carried out by ... At the cellular level, receptors include nuclear receptors that bring about changes in gene expression through up-regulation or ... several mechanisms including transcriptional regulation that can alter the activity of genes in response to changes. ...
MDR1 gene mutation[edit]. Recent research at Washington State University indicates that, in addition to many other herding ... breeds, approximately 15% of the English Shepherd population is subject to the MDR1 gene mutation. Dogs that are tested ...
Gene therapy. Gene therapy typically involves the use of a non-infectious virus (i.e., a viral vector such as the adeno- ... SNCA gene mutations are important in PD because the protein which this gene encodes, alpha-synuclein, is the main component of ... Genes implicated in the development of PD include SNCA, LRRK2, GBA, PRKN, PINK1, PARK7, VPS35, EIF4G1, DNAJC13 and CHCHD2.[50] ... The gene used leads to the production of an enzyme that helps to manage PD symptoms or protects the brain from further damage.[ ...
Gene prediction. References[edit]. *^ a b Shine, J.; Dalgarno, L. (1975-03-06). "Determinant of cistron specificity in ... Gene Expression Technology. 185. Academic Press. pp. 103-114.. *^ Stormo, Gary D.; Schneider, Thomas D.; Gold, Larry M. (1982- ... Gene annotation[edit]. The identification of RBSs is used to determine the site of translation initiation in an unannotated ... "Genes & Development. 15 (13): 1593-1612. doi:10.1101/gad.891101. ISSN 0890-9369. PMID 11445534.. ...
Epigenetic gene silencing of DNA repair genes occurs frequently in NSCLC. At least nine DNA repair genes that normally function ... Epigenetic promoter methylation in DNA repair genes in NSCLC Gene Frequency of hyper- (or hypo-) methylation DNA repair pathway ... ALK gene rearrangements[edit]. Up to 7% of NSCLC patients have EML4-ALK translocations or mutations in the ROS1 gene; these ... Gomes A, Reis-Silva M, Alarcão A, Couceiro P, Sousa V, Carvalho L (2014). "Promoter hypermethylation of DNA repair genes MLH1 ...
If a resistance gene is transferable, it could lessen the effect of the use of antibiotics. Out of ten common antibiotic genes ... Transferable Resistance Genes[edit]. One important consideration to determine the safety of Lactobacillus fermentum is ... In order for L. fermentum to be considered as a potential probiotic, it must not contain any transferable resistant genes. ... They are considered potential vectors of antibiotic resistance genes from the environment to humans or animals to humans.[9] ...
Natural products genes[edit]. S. lacrymans' genome encodes six annotated polyketide synthases (PKS1-PKS6), 15 nonribosomal ... NPS3 and its adjacent clustered aminotransferase gene (AMT1) were also found to be up-regulated during co-incubation with ... One genome is from Serpula lacrymans S7.9 (v2.0). The genome assembly is 42.73 Mbp, with a predicted number of 12789 genes. The ... second genome is from Serpula lacrymans S7.3 (v2.0). The genome assembly is 47 Mbp, with a predicted number of 14495 genes. The ...
Gene and protein expression[edit]. About 20,000 protein-coding genes are expressed in human cells and nearly 70% of these genes ... Some 250 of these genes are more specifically expressed in the esophagus with less than 50 genes being highly specific. The ... Many genes with elevated expression are also shared with skin and other organs that are composed of squamous epithelia.[25] ... "Expression of Human Skin-Specific Genes Defined by Transcriptomics and Antibody-Based Profiling". Journal of Histochemistry & ...
Gene[edit]. The human CysLTR2 gene maps to the long arm of chromosome 13 at position 13q14, a chromosomal region that has long ... The gene consists of four exons with all introns located in the genes' 5' UTR region and the entire coding region located in ... "Entrez Gene: CYSLTR2 cysteinyl leukotriene receptor 2".. *^ Thompson MD, Takasaki J, Capra V, Rovati GE, Siminovitch KA, ... Gene ontology. Molecular function. • protein binding. • G-protein coupled peptide receptor activity. • signal transducer ...
Gene ontology. Molecular function. • calcium ion binding. • protein binding. • ankyrin binding. • gamma-catenin binding. • beta ... "Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)".. *^ Fleming TP, Papenbrock T, Fesenko I, Hausen P, Sheth B ( ... Berx G, Becker KF, Höfler H, van Roy F (1998). "Mutations of the human E-cadherin (CDH1) gene". Human Mutation. 12 (4): 226-37 ... Mutations in this gene are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. Loss of function is ...
TP53 gene. tumor protein p53. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... Somatic TP53 gene mutations have been found in some cases of bladder cancer. Bladder cancer is a disease in which certain cells ... The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). This protein acts as a tumor ... Somatic TP53 gene mutations are common in ovarian cancer, occurring in almost half of ovarian tumors. These mutations result in ...
Genes contained within the family: 15 Approved Symbol. Approved Name. Previous Symbols. Synonyms. Chromosome. ...
Gene Siskel Film Center. of the School of the Art Institute of Chicago. 164 N. State Street , Chicago, IL 60601 *. Hotline: ( ... THE GENE SISKEL FILM CENTER IS AVAILABLE FOR RENTAL. Dynamic location for presentations meetings, trainings, and luncheons. ... From September 27 through 29, the Gene Siskel Film Center and Hibernian Transmedia invite you to whoop it up Irish-style with ... and Animation at the School of the Art Institute of Chicago in collaboration with the Gene Siskel Film Center and the Video ...
Please see our Protein phosphatases, catalytic subunits page to view the PPP1C genes, along with all other PPP genes. ... Genes contained within the family: 181 Approved Symbol. Approved Name. Previous Symbols. Synonyms. Chromosome. ...
Gene activation, the first step of protein production, starts less than one millisecond after a cell is stretched-hundreds of ... Cells will ramp up gene expression in response to physical forces alone, a new study finds. ... "The genes near the nuclear periphery cannot be activated even if you stretch them, whereas the genes that are close to the ... Force triggers gene expression by stretching chromatin More information: "Force-induced gene up-regulation does not follow the ...
These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a ... has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in ... Among the genes identified was CD276, a gene that encodes a protein located on the cell surface, as well as other known and ... NCI Researchers Discover Genes That Are Turned On at High Levels in Tumor-Associated Blood Vessels of Mice and Humans. ...
Among genes coding for eCB catabolic enzymes, expression of MGLL was lower in tumour tissue while PTGS2 was increased. It is ... Altered mRNA Expression of Genes Involved in Endocannabinoid Signalling in Squamous Cell Carcinoma of the Oral Tongue. ... expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. ...
Almost all PSEN1 gene mutations change single building blocks of DNA (nucleotides) in a particular segment of the PSEN1 gene. ... Wang B, Yang W, Wen W, Sun J, Su B, Liu B, Ma D, Lv D, Wen Y, Qu T, Chen M, Sun M, Shen Y, Zhang X. Gamma-secretase gene ... PSEN1 gene. presenilin 1. Enable Javascript to view the expand/collapse boxes.. Printable PDF Open All Close All ... The PSEN1 gene provides instructions for making a protein called presenilin 1. This protein is one part (subunit) of a complex ...
Much attention has recently focused on a gene fusion, TMPRSS2:ETS-related gene (ERG), that is frequently found in aggressive ... At the same time the literature indicates clearly that loss of expression of the PTEN tumour suppressor gene is also linked to ... These values were then converted to log base 10 and plotted against the Ct data points for the target gene or RuBisCO to ... Phosphatase and tensin homologue (PTEN) is one of the most studied tumour suppressor genes that influences a wide range of ...
... and ex vivo gene transfer. This was the first NIH Office of Recombinant DNA Activities-approved trial of human gene therapy for ... Carducci M. A., Ayyagari S. R., Sanda M. G., Simons J. W. Gene therapy for human prostate cancer. Cancer (Phila.), 75: 2013- ... GM-CSF gene-transduced PCA vaccines represent only one of several new approaches to active specific immunotherapy of PCA, which ... GM-CSF gene-transduced PCA vaccines increased antibody titers against prostate tumor cell line-associated antigens. This ...
Mendelian Genes Define the Commitment to Flowering- Understanding Plant Genes-The Cauliflower Gene-The "fruit-full" gene. A ... Understanding Plant Genes. Photos: (1) phenotype of the APETALA1 CAULIFLOWER double mutant. (A) phenotype of the APETALA1 ... Caption: Genes control Flowering Development in Plants: ...
Once Notch is activated, the activity of proneural genes decreases in these cells, probably due to the activation of genes in ... On the other hand, proneural genes mutants fail to develop neural precursor cells. The proneural genes are expressed in groups ... Skeath, J. B.; Panganiban, G. F.; Carroll, S. B. (1994). "The ventral nervous system defective gene controls proneural gene ... Co-expression of proneural genes in brain neuroblasts is transient and varies with the developmental stage. Proneural gene ...
Explore the normal functions of human genes and the health implications of genetic changes. ...
The classic culture-gene example is the rapid rise of a gene for digesting lactose. If you lack this gene, youll have trouble ... Culture and genes started selecting for each other: A new culture made a gene more valuable, and as the gene spread through the ... no one gene or set of genes can hardwire us for exploration. More likely, different groups of genes contribute to multiple ... Sometimes a gene rides such a wave passively, more or less by accident-the gene just happens to be common in the leading ...
Table: Selected genes with variants that have been associated with obesity. Gene symbol. Gene name. Gene products role in ... Genes are the basis for the signals and responses that guide food intake, and small changes in these genes can affect their ... Insulin-induced gene 2. Regulation of cholesterol and fatty acid synthesis. MC4R. Melanocortin 4 receptor. When bound by alpha- ... What do genes have to do with obesity?. Obesity is the result of chronic energy imbalance in a person who consistently takes in ...
Explore the normal functions of human genes and the health implications of genetic changes. ... URL of this page: Genes: D. ...
Holmes, Andrew (2012). "Genes, Brain and Behavior: At the vanguard of behavioral and genomic neuroscience". Genes, Brain and ... "OnlineOpen". Genes, Brain and Behavior. Wiley-Blackwell. Retrieved 2013-09-20. "Author Guidelines". Genes, Brain and Behavior. ... "Source details: Genes, Brain and Behavior". Scopus preview. Elsevier. Retrieved 2017-01-28. "Genes, Brain and Behavior". ... have cited Genes, Brain and Behavior most often, are (in order of descending citation frequency) PLoS ONE, Genes, Brain and ...
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... brings you the latest research into genetic and cell-based technologies to treat disease. It also publishes ... Celebrating 25 Years of Gene Therapy To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the most ... 25 Years of Gene Therapy. To celebrate 25 years of Gene Therapy, the Editor-in-Chief has selected 25 of the journals most ... Integrating gene delivery and gene-editing technologies by adenoviral vector transfer of optimized CRISPR-Cas9 components * ...
The Genes & Cells page features the latest news in genetics, cells, development, physiology, immune science, microbiology, ... Jumping genes are part of all that makes us human. Ask 10 people what makes humans human and youll probably get 10 different ... Current CRISPR gene drives are too strong for outdoor use, studies warn. Self-limiting genetic tools already in development may ... 25 SN: Charting lumpy space, Bronze Age movers and shakers, T. rexs slasher arms, gene editor corrects typos, the Great ...
The Genes & Cells page features the latest news in genetics, cells, development, physiology, immune science, microbiology, ... Jumping genes are part of all that makes us human. Ask 10 people what makes humans human and youll probably get 10 different ... Genes could record forensic clues to time of death. Scientists have found predictable patterns in the way our genetic machinery ... FORENSIC LENS A new approach to determining a bodys time of death looks for patterns in genes that are active after death. ...
Researchers uncover gene mutations that contribute to disease by screening the genomes of thousands of healthy and ill people ... Sick Genes. Researchers uncover gene mutations that contribute to disease by screening the genomes of thousands of healthy and ... "Its not about one gene.". Nevertheless, on average, having one copy of some of the newly identified genes raises a persons ... For example, researchers probing type 1 diabetes report in Nature and Nature Genetics that they found seven new genes and ...
It correlates to some extent with culture and economics but also to some extent with genes. Denying that race is real or that ... genes play a role in racial differences is just as simplistic as pretending that race explains everything or that ... gap may be the result of a complex interaction of differences in the biology of the tumors and inherited variations in genes ...
Genes to Cognition presents supporting information for grades 9-12 on cognitive disorders, cognitive processes, and research ... Genes To Cognition. By Phil Nast, retired middle school teacher and freelance writer ... Simple Mapper was used to organize the Genes to Cognition website and the software is available for free. Registration is ... And the heading Research Approaches includes information about bioinformatics, ethics, gene finding, model systems, ...
There is a repeat polymorphism in exon III of the gene at which a variable number of 48-bp motifs can occur. The common and ... Neutral genes would show no sharp boundary between the two populations, whereas alleles affecting behavior should show a sharp ... In such populations it would stay rare even in the presence of gene flow from neighboring populations, even from neighbors with ... They argue that complex adaptations require the coordinated action of many genes, and that if individuals of a sexually ...
  • Compared with breast cancers without TP53 gene mutations, tumors with these genetic changes tend to have a poorer prognosis: They are more likely to be aggressive, to be resistant to treatment with certain anti-cancer drugs and radiation, and to come back (recur) after treatment. (
  • How are genetic conditions and genes named? (
  • Explore the normal functions of human genes and the health implications of genetic changes. (
  • It's about hundreds of genes in your genome contributing a threshold of genetic susceptibility," Todd says. (
  • In addition to being a tempting target for 'cosmetic' genetic screening by parents undergoing IVF, eye colour genes will no doubt prove useful in forensic applications - being able to predict *any *physical traits from trace DNA left at the scene of a crime will at least occasionally be useful for investigators. (
  • The overlap between autism susceptibility genes and genes previously implicated in intellectual disabilities further supports the hypothesis that at least some genetic risk factors are shared by different psychiatric developmental disabilities. (
  • This was a genetic study in families, investigating how a person's genes might affect how well they can tolerate alcohol. (
  • Finally, they looked at the genetic code of the CYP2E1 gene in the 96 participants whose data showed the greatest evidence of a link between the CYP2E1 gene and alcohol tolerance, to see if they carried any variations that might affect the protein that the gene produced. (
  • The results appeared to show that alcohol tolerance was linked to a genetic region at the end of the long arm of chromosome 10, which contains the CYP2E1 gene. (
  • GENES-R-US is a genetic counseling service created and designed by a high school biology class and offered to high school health class (or home economics class) "couples expecting a child" as part of a family living project. (
  • The program asks the student couple if they would like to subscribe to the GENES-R-US genetic counseling service. (
  • Some possible genetic contributions include the role of polymorphisms in genes associated with serotonin, noradrenalin, and dopamine neurotransmission, such as variants of the.serotonin transporter genes which inhibit serotonin reuptake, leading to insufficiency of monoamines in the brain and thus predisposing to depression. (
  • Genes that regulate the circadian rhythm are another potential cause of genetic predisposition to depression by interfering with normal sleep and other body functions that depend on the circadian pacemaker. (
  • The transfer of genetic material between non-mating species, known as horizontal gene transfer (HGT), has attracted growing attention as a powerful mechanism for genetic evolution. (
  • GENE-TOX provides genetic toxicology (mutagenicity) test data from expert peer review of open scientific literature for more than 3,000 chemicals from the United States Environmental Protection Agency (EPA). (
  • The encoding of multiple peptides in a single mono- cistronic mRNA appears to be a genetic mechanism for the gener- ation of biologic diversification without requiring amplification of gene sequences. (
  • In order for each cell to know what to do during development, it follows a genetic blueprint, which consists of complex webs of interacting genes called gene regulatory networks. (
  • The model is also a powerful tool for understanding gene regulatory networks in a way not previously possible, allowing scientists to better study the genetic bases of both development and evolution. (
  • By comparing the gene regulatory networks of different species, biologists can probe how they branched off from common ancestors at the genetic level. (
  • Yet genetic experiments in lower organisms and our own centenarian pedigree data indicate that at least a few genes may exist that exert a powerful influence upon longevity. (
  • It describes the frontier of research-the use of synthetic genes to "protect against disease," while changing the genetic makeup of humans. (
  • They hope to fill in the genetic blanks by studying the genes of similar cheetah populations in modern-day Iran. (
  • Other gene banks, such as Iceland's deCODE project, store human genetic material for medical research. (
  • Based on the trends they saw, the group concluded there were racial differences at the genetic level - despite lack of any data on genes. (
  • While 95 percent of dogs sampled had coats that could be explained by the three genes, a few breeds showed that they must be getting some genetic information from elsewhere, so researchers still have a little work to do to explain dogs completely. (
  • Each person has thousands of genes -- billions of base pairs of DNA or bits of information repeated in the nuclei of human cells --which determine individual characteristics (genetic traits). (
  • Scientists from University College London studied 359 men who either had two copies of the high-risk gene, or two copies of a genetic variant thought to cause low risk of obesity. (
  • In a recent study published in the New England Journal of Medicine, researchers from the Cincinnati Children's Hospital Medical Center and other institutions combed through genetic data and surveys from 23andMe to see if certain genes were linked to a risk for preterm birth. (
  • They also compared these findings with genetic data from 8,000 Nordic women to decipher which genes were most likely to put women at risk for preterm birth. (
  • The presence of the gene variant was checked easily with a genetic cheek swab, Cramer says. (
  • In addition to sequencing the DNA of a number of lower research organisms, they are rapidly identifying unique genetic markers along the entire length of human DNA--the equivalent of mile markers along a highway--which facilitate the discovery of interesting new genes, including those associated with elusive human diseases. (
  • Using a series of elegant experiments, Mendel formulated a theory that genetic traits were passed unchanged from one generation to the next in units he named Merkmales (now called genes), and that each plant's characteristics depended on the interaction of two of these Merkmales , one inherited from each parent. (
  • Utilizing bioinformatic databases - which contain an abundance of information related to various genes and their genetic associations - the UA researchers first mined the data, prioritizing 867 genes for testing. (
  • After studying the genes of the people in the study, the scientists detected genetic patterns among children who were infected with TB and those who were not, particularly relating to two specific chromosomes. (
  • Genetic studies are yielding evidence associating particular variants of the CARD15 gene with the prognosis of Crohn disease. (
  • Because of this ruling, patients will have greater access to genetic testing and scientists can engage in research on these genes without fear of being sued. (
  • Global Genes is a global non-profit advocacy organization for individuals and families fighting rare and genetic diseases. (
  • The organization is associated with a blue denim "Genes Ribbon" that is intended to raise awareness of patients affected by rare and genetic diseases. (
  • The scientists observed that H3K9 methylation was highest at the periphery of the nucleus and largely absent from the interior, making the genes in the interior more responsive to stretching. (
  • The scientists also tested whether the frequency of an applied force influenced gene expression . (
  • The entry for ADHD is representative and includes brief videos with scientists (transcripts are included), print material, and graphics under subheadings: genes, biochemicals, cells, brain anatomy, cognition, and environment explaining each factor's role in ADHD. (
  • Using Computing Life, the scientists were able to unravel how a network of genes and their products tell time, thereby demonstrating the solution of one of the key problems in systems biology. (
  • The UGA scientists discovered how three genes in Neurospora make such a clock tick at the molecular level. (
  • The scientists have identified at least 80 genes linked to depression. (
  • In an update, the scientists identified 102 gene variants and 269 genes associated with depression. (
  • Now scientists have identified a specific gene that conceivably could push a runner over the line between good and great. (
  • Of course it takes more than genes to develop an elite athlete, but scientists are learning more just how much genes do contribute to superior athletic ability. (
  • This model, the scientists say, does a remarkably good job of calculating what these networks do to control the fates of different cells in the early stages of sea-urchin development-confirming that the interactions among a few dozen genes suffice to tell an embryo how to start the development of different body parts in their respective spatial locations. (
  • By delivering synthetic genes into the muscles of the [experimental] monkeys, the scientists are essentially re-engineering the animals to resist disease. (
  • Scientists isolate the genes that produce powerful antibodies against certain diseases and then synthesize artificial versions. (
  • While seed banks typically prioritize widely grown crop plants, scientists looking to stockpile animal genes focus in a different direction: species on the verge of extinction. (
  • In the short term, such gene banks allow scientists to study endangered species and learn how best to sustain them in the future. (
  • A common family environment - whether it promotes or hinders early sex - could cause scientists to overestimate the effect of genes. (
  • On the other hand, conservative social mores might delay a teen's first sexual experience, causing scientists to low-ball the effect of genes. (
  • Scientists are increasingly finding that propensities for human behaviors -- for addiction, aggression, risk-taking and more -- are written in our genes. (
  • The process of identifying these genes, called disease gene discovery, is important because it helps scientists to understand what is going wrong as a result of such diseases, called the disease pathogenesis. (
  • A breakthrough new technique enables scientists to image 10,421 genes at once within individual cells. (
  • Research scientists at Karolinska Institutet are planning an international initiative to map out the relationships between health, genes and lifestyle. (
  • The scientists smuggled a gene into the chloroplast DNA and equipped it with a riboswitch. (
  • By way of example, the Potsdam-based scientists modified the genes of the tobacco plant such that it was able to produce large quantities of an antibiotic in its leaves. (
  • To learn about the plight of these giant creatures and the forces that contributed to their extinction, scientists have resurrected a Wrangel Island mammoth's mutated genes. (
  • The scientists did this for genes that are thought or known to be involved in a range of important functions, including neurological development, male fertility, insulin signaling and sense of smell. (
  • Until the early 1950s, there was no consensus among scientists about what genes were even made of, though the concept of genes as a unit of hereditary information has been around for 130 years. (
  • In a possible first step toward a far-off day when mosquitoes would be rendered incapable of carrying diseases like malaria, scientists at Colorado State University have inserted foreign genes into mosquitoes. (
  • To narrow down earlier determined chromosomal loci associated with comitant strabismus to single genes, the scientists used three different linkage-analysis methods - the term linkage refers to the tendency of genes to be inherited together due to their proximity on one and the same chromosome. (
  • Scientists are working toward identifying the location and function of each gene in the human genome (see Human Genome Project ). (
  • Scientists seek to use gene from deadly disease as new cancer treatment… could it actually work? (
  • The hVps37A gene as such is not unknown to scientists. (
  • Whereas the study of DNA by itself is very important for understanding how different functions can work, RNA tells scientists which genes are actually active in the body, according tothe U.S. National Institutes of Health . (
  • So far, rare variants in at least nine genes have been implicated in single-gene (monogenic) obesity. (
  • Several of these genes also have variants that are associated with monogenic obesity, a phenomenon that has been observed in many other common conditions. (
  • Some genes with variants that have been associated with obesity are listed in the Table . (
  • The authors examined all of the 37 variants (in 8 separate genes) previously reported to have an association with eye colour in a sample of 6,168 Dutch of European ancestry, and assessed the predictive value of these markers alone and in combination. (
  • Adding further markers had rapidly diminishing returns, with the last 15 markers adding essentially nothing further in terms of predictive value (these markers were typically captured by other variants within the same gene). (
  • Findings show that the DNA of individuals with ASDs has more copy number variants (CNVs) - rare submicroscopic insertions and deletions - disrupting genes, including genes previously reported to be associated with autism, but also other genes such as those involved in intellectual disabilities. (
  • Do black people carry certain gene variants that give them weaker hearts? (
  • Specific variants of genes involved in inflammation and blood vessel constriction are strongly associated with kidney damage in patients undergoing major heart surgery, researchers at Duke University Medical Center have found. (
  • Now, Deborah Waber, Ph.D, and colleagues at Boston Children's Hospital, Massachusetts, U.S., have found four specific gene variants that appear to raise the risk. (
  • This retrospective analysis tells us that going forward we may wish to examine children's genotypes at baseline and conduct prospective research to learn why these specific gene variants may increase risk of toxicity. (
  • But our own two laboratories have focused on a gene called SIR2 , variants of which are present in all organisms studied so far, from yeast to humans. (
  • These genes, and the proteins they encode, are important new potential targets for novel drugs that could selectively cut off a tumor's blood supply without affecting the blood vessels of healthy tissues, overcoming one of the major concerns of current anticancer therapies targeted at blood vessel growth. (
  • Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor cells. (
  • Proneural genes encode a group of bHLH proteins that play crucial roles in controlling cell fate in a variety of tissue types. (
  • Only 4% of essential genes encode unknown functions. (
  • Their expression pattern is collinear, that is, the order of genes in the cluster reflects the temporal and spatial sequence of gene activation in the organism. (
  • Among ≈4,100 genes of the organism, only 192 were shown to be indispensable by this or previous work. (
  • Finally, the use of antisense RNA is limited to the genes for which an adequate expression of the inhibitory RNA can be obtained in the organism under study. (
  • We found that some 25 percent of the genes in our model organism appear to be under clock control. (
  • Likewise, if an organism is true-breeding , both genes that control the same trait had to be the same gene ( homozygous ). (
  • When two different alleles for the same trait are found in an organism, the gene that is expressed is the dominant allele , and the gene not expressed is the recessive allele . (
  • This network-so far the most extensively analyzed developmental gene regulatory network of any animal organism-consists of about 50 regulatory genes that turn one another on and off. (
  • Genes govern both the structure and metabolic functions of the cells, and thus of the entire organism and, when located in reproductive cells, they pass their information to the next generation. (
  • Consider an organism whose genes would make it immortal and cause it to continually produce offspring. (
  • However, eventually conditions will change and the genes which made the organism immortal in the old environment will fail in the new environment. (
  • WE FIRST DISCOVERED that SIR2 is a longevity gene by asking what causes individual baker's yeast cells to grow old and whether a single gene might control aging in this simple organism. (
  • The study of inherited cancers has given cancer molecular biologists the opportunity to search for genes that are critical in normal cell development and cancer. (
  • In other words, the researchers represented the network as a series of if-then statements that determine whether certain genes in different cells are on or off (i.e., if gene A is on, then genes B and C will turn off). (
  • A recent study has shed light on this problem by identifying certain genes that appear to be linked to an increased risk for women giving preterm birth, or before 37 weeks' gestation. (
  • Some children who are treated for acute lymphoblastic leukemia (ALL) develop brain impairments, and the risk of this happening may be linked to certain genes. (
  • Rarely, obesity occurs in families according to a clear inheritance pattern caused by changes in a single gene. (
  • The transmission disequilibrium test (TDT) and the TDT allowing for errors - essentially, statistical tests on paired data - and a linkage analysis under dominant and recessive inheritance pointed to two genes as potential loci of the SNP for comitant strabismus, abbreviated MGST2 and WNT2. (
  • gene, the structural unit of inheritance in living organisms. (
  • All of the F 1 (first generation) offspring are heterozygous, meaning they contained both a dominant and recessive gene, RrYy, round and yellow. (
  • For example, the gene for brown eyes is dominant while the gene for blue eyes is recessive, so if you get one copy of the brown eye gene from one parent and a copy of the blue eye gene from the other, you will have brown eyes. (
  • Genes can be either dominant or recessive . (
  • and doctoral student Erfan Mohagheghian discovered that mechanical forces on cells can boost gene expression in the nucleus. (
  • Cells will ramp up gene expression in response to physical forces alone, a new study finds. (
  • Previous studies revealed that some genes are susceptible to physical manipulations of cells, but Wang and his colleagues were the first to show that stretching cells alone could influence how such genes are expressed. (
  • The team first demonstrated this phenomenon with genes they had inserted in cells. (
  • In a Phase I human gene therapy trial, eight immunocompetent prostate cancer (PCA) patients were treated with autologous, GM-CSF-secreting, irradiated tumor vaccines prepared from ex vivo retroviral transduction of surgically harvested cells. (
  • From the same ectodermal cell types, neural or epidermal cells can develop based on interactions between proneural and neurogenic genes. (
  • On the other hand, proneural genes mutants fail to develop neural precursor cells. (
  • The proneural genes are expressed in groups of cells (proneural clusters) from which one progenitor cell - typically the one in the middle - will be singled out, leading to the formation of many different types of neurons in the central and peripheral nervous systems. (
  • The cells within a cluster that express a proneural gene (called a proneural cluster) can be thought of as cells of an equivalence group. (
  • In neuroectoderm, neurogenic genes are required to single out cells from within proneural clusters to form neuronal precursors, leaving the remaining cells of proneural clusters to develop into epidermal cells. (
  • Gene regulation networks, consisting of a subset of genes called transcription factors, control cellular activity, producing the right gene activities for the many situations that the multiplicity of cells in our bodies face. (
  • This allows the expression of genes to be finely tuned to the variable microenvironments of cells. (
  • The model encompasses the gene regulatory network that controls the first 30 hours of the development of endomesoderm cells, which eventually form the embryo's gut, skeleton, muscles, and immune system. (
  • All the cells in the body (except egg and sperm) contain the same genes. (
  • Immunoglobin Genes is the first comprehensive book on the structure, function, and expression of the genes encoding antibodies in normal and neoplastic cells. (
  • The viruses invade human cells with their DNA payloads, and the synthetic gene is incorporated into the recipient's own DNA. (
  • If all goes well, the new genes instruct the cells to begin manufacturing powerful antibodies. (
  • Previously, researchers could only image four to five genes at a time in cells with microscopy. (
  • Scaling seqFISH up to a genomic level now enables the imaging of over 10,000 genes--about half of the total number of genes in mammals--within single cells. (
  • Seeing introns reveals which genes are currently turned on in individual cells, how strongly they are expressed, and where they are located. (
  • Doctors removed her white blood cells, inserted the missing gene into the WBC, and then put them back into her blood stream. (
  • hemophilia treatments, for example, a gene-carrying vector could be injected into a muscle, prompting the muscle cells to produce Factor IX and thus prevent bleeding. (
  • Because it appears to be of major significance, there is great importance to study how this gene functions in normal cells compared to cancer cells. (
  • The gene p53 usually acts as a cell growth regulator (stops cells from continually dividing). (
  • On the whole, the results from this FWF project offer the first fundamental description of a previously unknown tumour suppressor gene in ovarian cancer cells. (
  • One of us (Guarente) began by screening yeast colonies for unusually long-lived cells in the hope of finding genes responsible for their longevity. (
  • The restored genes represent a new genomic network that regulates the integrity of neuronal structure in the hippocampus and is targeted by aging. (
  • However, essential genes related to cell envelope, shape, division, and respiration tend to be lost from bacteria with small genomes. (
  • A computational approach, based on the assumption that essential genes are conserved in the genomes of M. genitalium and Haemophilus influenzae , led to a description of a smaller set of some 260 genes ( 2 ). (
  • Because all the cancers for which the disparity persisted were related to gender, the findings suggest that the survival gap may be the result of a complex interaction of differences in the biology of the tumors and inherited variations in genes that control metabolism of drugs and hormones, [Kathy Albain, the study's lead author] said. (
  • The findings, published in the Journal of Clinical Investigation , could explain why people with the high-risk variant of the FTO gene have larger appetites and eat higher-calorie foods, as shown in previous research. (
  • Despite the significant findings, Cole adds that further work must be done to confirm the role of the four genes. (
  • Their findings suggest that the two genes are involved in the development of a condition known as comitant strabismus. (
  • It was known already that both MGST2 and WNT2 are expressed in the brain, and the findings of the two researchers show that the two genes are likely to play a role in the development of comitant strabismus. (
  • Drawing on work from artificial intelligence and philosophy of mind, he argues that the key lies in how multiple transcription factors combine to regulate a single gene, acting in a way that is qualitatively consistent. (
  • 1969 - The first single gene is isolated. (
  • Some characteristics come from a single gene, whereas others come from gene combinations. (
  • Genes, Brain and Behavior (also known as G2B) is a peer-reviewed online-only scientific journal covering research in the fields of behavioral, neural, and psychiatric genetics. (
  • The five journals that as of 2016[update] have cited Genes, Brain and Behavior most often, are (in order of descending citation frequency) PLoS ONE, Genes, Brain and Behavior, Scientific Reports, Neuroscience & Biobehavioral Reviews, and Behavioural Brain Research. (
  • Genes to Cognition presents supporting information for grades 9-12 on cognitive disorders, cognitive processes, and research approaches in brain studies. (
  • Identification of unknown and unexpected essential genes opens research avenues to better understanding of processes that sustain bacterial life. (
  • Before the current research, only 16 clock-controlled genes had been discovered in Neurospora in more than 40 years of research. (
  • Your genes could be a strong predictor of whether you stray into a life of crime, according to a research paper co-written by UT Dallas criminologist Dr. J.C. Barnes. (
  • The analysis doesn´t identify the specific genes that underlie the different pathways, which Barnes said would be an interesting area for further research. (
  • A research team at RIKEN, Japan's flagship research organization, has uncovered the first ever evidence of nuclear gene transfer from host to parasite plant species. (
  • Instead, these improved habits change the expression of the genes, says Dean Ornish, M.D., lead study author and founder and president of the nonprofit Preventive Medicine Research Institute in Sausalito, California. (
  • Fretwell, who was not involved with the research, said that the results of the study match expectations, in that three genes had a large impact. (
  • This work builds off of previous advances from the Cai laboratory, including an earlier version of seqFISH from 2014 and research from 2017 that profiled over 10,000 genes under a microscope. (
  • Phoenix-Researchers at the Translational Genomics Research Institute (TGen) and Kronos Science Laboratories, an affiliate of Phoenix-based Kronos Optimal Health Company, have initiated a study with unprecedented power to identify genes that are involved in the development of Alzheimer's disease, the most common form of disabling memory and thinking problems in older persons. (
  • Gene patents have supporters who see them as essential for the development of diagnostic and therapeutic products and detractors who see them as hindering research directly and indirectly. (
  • The Dartmouth College Institutional Biosafety Committee for Clinical Gene Transfer (IBC-CGT) is a multidisciplinary committee charged with the review of clinical protocols involving gene transfer as defined in the NIH Guidelines For Research Involving Recombinant Or Synthetic Nucleic Acid Molecules , March 2013. (
  • Other changes in genes can cause health problems. (
  • At the molecular level, cancer formation is characterized by changes in genes, such as p53. (
  • Here we have investigated, at the mRNA level, expression of genes coding for the components of the eCB system in tumour and non-malignant samples from SCCOT patients. (
  • It said, "US researchers believe 10% to 20% of people have a version of the gene that may offer some protection against alcoholism. (
  • Furthermore, the short version of the gene, called the 'S allele', has been linked to a heightened risk of depression, especially if the person has been through adverse childhood events. (
  • Others have linked the same version of the gene - called DRD4 - to impulsive, risk-taking behaviour. (
  • Proneural genes promote neurogenesis and inhibit gliogenesis but some neurogenic factors can regulate both of these processes, depending on the proneural genes concentration. (
  • Another experimental approach using antisense RNA to inhibit gene expression led to the identification of some 150 essential genes in Staphylococcus aureus ( 5 ). (
  • We think that Myriad Genetics' patents on BRCA 1 and 2, and how these patents have been upheld in court challenges in the US , illustrate how gene patents can elicit cases of preemptive obedience which is problematic for patients and researchers alike. (
  • Myriad did not invent the BRCA genes and should not control them. (
  • Researchers have discovered five genes that convey protective capabilities against a hallmark trait of Parkinson's disease. (
  • Foreign genes have another advantage in the chloroplasts besides this: they are inherited almost without exception through the female egg cell. (
  • It is therefore extremely rare for foreign genes to spread through the pollen of the tobacco plants. (
  • They are all regulatory genes that bind DNA to switch other genes off and on. (
  • Despite the impact of these biological processes in circadian rhythm and possible effect on circadian control, the clock gene did not seem to be diurnally regulated in peripheral tissues. (
  • That is because genes, although potent predictors, are not always the sole cause of particular diseases. (
  • Nevertheless, on average, having one copy of some of the newly identified genes raises a person's chances of developing one of the seven studied diseases by 20 to 40 percent, and those with two copies face nearly double that risk, researchers say. (
  • The same genes that play key roles in sports performance also sometimes figure in common chronic problems such as cardiovascular diseases, diabetes, osteoporosis, obesity and others. (
  • In recent years, the U.S. Patent and Trademark Office has allowed about 20 percent of human genes to be patented, including those associated with common diseases such as Alzheimer's, asthma, and colon cancer. (
  • They get all the same diseases humans do and the same genes are likely to be involved. (
  • Other articles examine crucial applied questions, such as how genes influence autoimmune thyroid diseases, or which chickens are the most resistant to colonization by Campylobacter jejuni , one of the most common causes of food-borne illness in humans. (
  • The flip side of plasticity is stability, Cramer explains, and with some brain conditions, such as Parkinson's disease and other neurodegenerative diseases, the bad-driving gene gives stability to the brain, meaning it might slow the progression of the degenerative disease. (
  • The project has already accelerated the identification of genes associated with human diseases and the development of new drugs to treat them. (
  • With the advent of molecular biology applications to medicine, gene maps and the chromosomal locations of genes are available as tools for the identification of predisposition for various diseases. (
  • Natural News) Back in 2015, The New York Times published an article entitled, "Protection Without a Vaccine," an in-depth look at immunoprophylaxis by gene transfer, or I.G.T. Described as a "novel approach" to fighting serious diseases like H.I.V., Ebola , malaria, hepatitis and even the common flu, the researchers involved in the development of I.G.T. (
  • This implies that if our present environment, where the probability of being killed by predators, starvation or diseases before reaching old age is much smaller than in the original human environment, would continue to exist for a million year or so, natural selection would promote genes that would make us live longer. (
  • If we could identify the gene or genes that serve as its master controllers and thereby act as master regulators of an organism's life span, these natural defense mechanisms might be turned into weapons against the diseases and decline that are now apparently synonymous with human aging. (
  • Using molecular tools it was possible to isolate the first four genes of this complex: achaete (ac), scute (sc), lethal of scute (lsc) and asense (ase). (
  • Now connectionist modeling returns to molecular biology to explain development via regulatory gene networks. (
  • This book reviews the molecular biology of the gene in relation to aging. (
  • Genes and Aging is for all students and researchers interested in the molecular biology of aging. (
  • So the theophylline riboswitch allows us to switch a gene on or off at will and see what effects result," explains Ralph Bock from the Max Planck Institute of Molecular Plant Physiology. (
  • Virus Genes is dedicated to the publication of studies on the structure and function of viruses and their genes, the molecular and systems interactions with the host and all applications derived thereof, providing a forum for the analysis of data and discussion of its implications, and the development of new hypotheses. (
  • This singling out process is mediated by cell-cell interactions interpreted through the action of neurogenic genes. (
  • Most obesity seems to be multifactorial, that is, the result of complex interactions among many genes and environmental factors. (
  • And underlying all these processes and their intricate interactions are the genes that govern their function. (
  • It is an exciting development to see Dr. Buxbaum and colleagues identify genes that have been linked to intellectual disabilities but not previously implicated in autism now be linked to that condition as well," commented Bruce D. Gelb, MD, Director of the Child Health and Development Institute at Mount Sinai. (
  • Because of the nature of both development and its evolution, we can gain insight into the developmental process when we identify gene regulation networks as the controllers of development. (
  • Within these samples, they were able to identify the same eight-gene signature at work. (
  • Two of the objectives in the assembly of this book are to pre- sent, in one volume, the known primary structures of the genes encoding several of the polypeptide hormones and related regulatory peptides, and to provide an account of the various ap- proaches that have been used to identify and select the cloned genes encoding these polypeptides. (
  • Researchers didn't identify the exact mechanism for how the genes react, but they did call attention to the fact that both sedentary lifestyles and physical activity had independent effects on BMI. (
  • Flow chart of the linkage analyses carried out by Okayama University researchers to identify the genes associated with comitant strabismus based on the DNA of 204 individuals in 58 Japanese families. (
  • Dr.Toshihiko Matsuo performed SNP analyses to identify single genes responsible for comitant strabismus in Japanese families. (
  • Though the decision invalidates patents covering the BRCA1 and BRCA2 genes, which underlie Myriad Genetics' BRACAnalysis test, the firm noted in a statement after the decision that "many of Myriad's unchallenged claims are method claims applying knowledge about the BRCA1 and BRCA2 genes. (
  • Polymorphisms of clock genes, at least within animal models, can lead to impaired glucose tolerance and insulin resistance and contribute to obesity and perturbate fatty acid metabolism (Garaulet, M. et al. (
  • These data suggest that both T-cell and B-cell immune responses to human PCA can be generated by treatment with irradiated, GM-CSF gene-transduced PCA vaccines. (
  • Feng Zhang of the Broad Institute of MIT participates in a panel discussion at the National Academy of Sciences international summit on the safety and ethics of human gene editing, Tuesday, Dec. 1, 2015, in Washington. (
  • A public resource model would also alleviate the unsettling prospect of something as fundamental as human DNA being owned by private entities-an idea that might not even make sense in the future, as the diagnosis of disease points toward a complicated interaction of genes and other factors. (
  • The first human trial based on this strategy - called immunoprophylaxis by gene transfer, or I.G.T. - is underway, and several new ones are planned. (
  • The genes are placed into viruses and injected into human tissue, usually muscle. (
  • According to the official Guidelines for Human Gene Nomenclature, a gene is defined as "a DNA segment that contributes to phenotype/function. (
  • They would insert human genes into a bacteria cell. (
  • Phosphatase and tensin homologue ( PTEN ) is one of the most studied tumour suppressor genes that influences a wide range of cellular processes including survival, proliferation, adhesion, migration, metabolism and differentiation. (
  • A team of researchers at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH), has uncovered a set of genes that are turned on, or expressed, at high levels only in the blood vessels that feed tumors in mice and humans. (
  • The author presents basic information on eukaryotic genes and follows this with details of the changes that occur in their structure and function during aging. (
  • The legal question has been, are these discoveries natural entities that cannot be patented, or can a diagnostic test involving a particular gene be considered intellectual property? (
  • The vast majority of essential genes were categorized in relatively few domains of cell metabolism, with about half involved in information processing, one-fifth involved in the synthesis of cell envelope and the determination of cell shape and division, and one-tenth related to cell energetics. (
  • This is influenced by a gene that codes (instructs) for an enzyme involved with both oestrogen and caffeine metabolism. (
  • The gene codes for the CYP1A2 enzyme, which plays a role in both coffee and oestrogen metabolism. (
  • The four highlighted genes, NOS3, SLCO2A1, HFE, and COMT, were among a group of 28 genes investigated due to their roles in drug metabolism or cellular damage responses. (
  • There were a lot of genes associated with metabolism - functions like lipid metabolism and nitrogen metabolism pathways that clearly were expressed more during pregnancy, Jennings said. (
  • Carbohydrate metabolism: positive selection was observed for genes involved in breaking down mannose in Yorubans, sucrose in East Asians, and lactose for Europeans. (