Biology 1201 - Eucaryotic Gene Regulation Genome Structure Genes DNA and chromosomes Complete Genome DNA sequence know humans...

Mouse Major Urinary Protein 3 Research Products: Novus Biologicals

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human...

The Evolution of Mutator Genes in Bacterial Populations: The Roles of Environmental Change and Timing | Genetics

The methanol dehydrogenase structural gene mxaF and its use as a functional gene probe for methanotrophs and methylotrophs. |...

Research Resource

Nome News Issue 23 | HUGO Gene Nomenclature Committee

Nome News Issue 7 | HUGO Gene Nomenclature Committee

LOC100420794 Gene - GeneCards | LOC100420794 Pseudogene

ATP5PBP6 Gene - GeneCards | ATP5PBP6 Pseudogene

pGenN, a Gene Normalization Tool for Plant Genes and Proteins in Scientific Literature

High-level, erythroid-specific expression of the human alpha-globin gene in transgenic mice and the production of human...

Category:Charon - Wikimedia Commons

Anthropogenetical Analysis of Abnormal Human -globin Gene Cluster Arrangement on Chromosome 16* - pdf descargar

GPSy: a cross-species gene prioritization system for ... - HAL - TechyLib

Molecular mechanisms of globin gene regulation and disregulat...

Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells. - Radcliffe...

Functional characterization of a human histone gene cluster duplicatio by Corey D. Braastad, Hayk Hovhannisyan et al.

Hpal polymorphic site 3 of the human β-globin gene is inside a repetitive sequence and cannot be ascertained by polymerase...

Euglena gracilis chloroplast psbB, psbT, psbH and psbN gene cluster: Regulation of psbB-psbT pre-mRNA processing | SpringerLink

Exon sequences are conserved, but intron sequences vary | Organization of Genetic Material Split Genes, Overlapping Genes and...

Cloning and characterization of an alpha 1-antitrypsin like gene 12 KB downstream of the genuine alpha 1-antitrypsin gene

Convert an intron-style GFF3 file into an exon-style GFF3 file

Symbol report help | Vertebrate Gene Nomenclature Committee

Mus musculus major urinary protein 5 (Mup5), mRNA - Nucleotide - NCBI

Analysis of the human alpha-globin gene cluster in transgenic mice. - MRC Weatherall Institute of Molecular Medicine

Human Gene Nomenclature - AMA Manual of Style

Human Gene Nomenclature - AMA Manual of Style

Rat Genomic DNA | 69238

Journal: Theoretical and applied genetics / Source: 1990 v.80 no.3 / Subject: DNA and restriction mapping - PubAg Search Results

Consider two unlinked genes P and Q A plant with genotype class 12 biology CBSE

Exploring the contribution of gene dosage effects of 17q gain on ESC and neuroblastoma proliferation

Gupta et al have shown

Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. | The...

Patent US7918817 - Splittable multiple catheter assembly - Google Patents

Structural organization and chromosomal localization of the human Na,K-ATPase β3 subunit gene and pseudogene | SpringerLink

Malignant characteristics of somatic cell hybrids of normal human and by M R. Bordelon

Ref - Eiglmeier et al. 1987. Mol.Microbiol. 1:251-258

GENETICAL AND BIOCHEMICAL STUDIES OF HISTIDINE-REQUIRING MUTANTS OF NEUROSPORA CRASSA. IV. LINKAGE RELATIONSHIPS OF hist-3...

Global Genes

Mom Genes

Genes (journal)

Luz Genes

Dalla genes

Wilfredo Genes

Reference genes

Blue Genes

Pax genes

Evil Genes

Paola Genes

Halloween genes

Genes Reunited

Skinny Genes

Víctor Genes

Genes & Development

Proneural genes

Genes (album)

Genes & Immunity

Genes & Diseases

Jeans for Genes

Blue Genes (album)

In My Genes

Genes (season 2)

Genes, Chromosomes & Cancer

Auxiliary metabolic genes

Genes to Cells

Tandemly arrayed genes

Genes (game show)

Genes (season 3)

20221

• La información en esta página debería ser considerada como ejemplos de información de antecedentes para la temporada de influenza 2021-2022 para la práctica médica respecto del uso de medicamentos antivirales contra la influenza. (cdc.gov)

Genetic34

• Genetic disorders often are described in terms of the chromosome that contains the gene that is changed in people who have the disorder. (cdc.gov)
• If the gene is on one of the first 22 pairs of chromosomes, called the autosomes, the genetic disorder is called an autosomal condition. (cdc.gov)
• Some genetic diseases are caused by a DNA mutation in one of a person's genes. (cdc.gov)
• In fact, for many who choose to undergo genetic testing, specific tests may uncover gene mutations that can show an increased risk for a particular disease . (go.com)
• Explore the normal functions of human genes and the health implications of genetic changes. (medlineplus.gov)
• Global Genes is a global non-profit advocacy organization for individuals and families fighting rare and genetic diseases. (wikipedia.org)
• The organization is associated with a blue denim "Genes Ribbon" that is intended to raise awareness of patients affected by rare and genetic diseases. (wikipedia.org)
• In 1996, a working group from the Centers for Disease Control and Prevention published an article in the American Journal of Public Health entitled: "From Genes to Public Health: Applications of Genetic Technology in Disease Prevention. (cdc.gov)
• Previous studies had shown that as sperm and eggs develop, any markings added to genes during life are erased to provide a genetic "blank slate" from which the next generation develops. (newscientist.com)
• Brooks' attempt is to slap back at genetic determinism, but it sounds like he could be describing a gene-environment correlation . (scienceblogs.com)
• The work suggests that evolution may use the same genetic toolkit across species for behavioral traits, much in the way that related genes are used for building body parts, whether in a fruit fly or frog. (sciencenews.org)
• That's genetic self-engineering: Each healthy act switches on youth-promoting genes and switches off genes that cause you to age. (nationalgeographic.com)
• These enhancers can help turn genes on and off as a growing embryo would need, but as we have seen in other genetic mechanisms of embryonic development, they can lead to cancer if they are switched on inappropriately in adult cells. (genengnews.com)
• While previous research into twins has indicated that genes are at least partially responsible for controlling handedness, the new study, conducted by scientists from the University of Oxford and published in the journal Brain , is the first to identify which genetic variants separate the lefties from the righties. (cnn.com)
• About half of the human genome, and a fifth of the fruit fly genome, is composed of genetic parasites resembling genes that can make copies of themselves, and insert themselves into random areas of our genome, potentially disrupting normal gene expression. (oeaw.ac.at)
• The findings, published Thursday in the journal Cell Reports, are encouraging news for the roughly 1 in 5 people who have the genetic trait, which is a variant of the klotho gene. (sfgate.com)
• As little as five years ago, only a handful of genes had been identified, all of which caused complex genetic syndromes, like Fragile X, Rett's, and Down syndromes, of which ASD is one of several possible comorbid features. (nih.gov)
• In cooperation with the National Human Genome Research Institute and the National Institute on Alcohol Abuse and Alcoholism , the National Institute of Environmental Health Sciences will host a half-day public symposium beginning at 8:30 a.m. April 16 in the Masur Auditorium of the Clinical Center (Building 10) NIH, Bethesda, Md., on Genetic Variation and Gene-Environment Interaction in Human Health and Disease. (nih.gov)
• Biological evolution requires a direct genetic connection through inheritance (vertical transmission), punctuated by occasional events of horizontal gene transfer (for example, through viruses inserting DNA). (theness.com)
• Genetic testing had indicated that Girard carried mutations on two genes known as BRCA1 and BRCA2, placing her at a significantly higher risk of developing hereditary breast and ovarian cancers. (womensenews.org)
• In the last three years, Emory's molecular genetics laboratory has developed new gene sequencing tests for more than 200 rare genetic diseases, many of which were previously unavailable as clinical tests. (womensenews.org)
• But the genetic diagnostics program Ledbetter heads at Emory can only invest in research for new tests when no gene patent or exclusive licensing agreement creates a monopoly. (womensenews.org)
• Gene therapy involves -inserting genetic material into a -malfunctioning cell to alter its activities and cure disease. (ieee.org)
• Generally, genetic engineers start by injecting into a -target region a virus that has been -modified to include human genes. (ieee.org)
• Bovine lactiae , the 16S rRNA gene was amplifi ed by PCR and isolates carried other genetic determinants, such as com- sequenced ( 5 ). (cdc.gov)
• Autosomal dominant genetic transmission indicates that one copy of the altered gene is required for phenotypic expression. (medscape.com)
• Neurofibromatosis type 1 (NF1), also known as peripheral neurofibromatosis or von Recklinghausen disease, is an autosomal dominant genetic condition caused by a mutation in or a deletion of the NF1 gene. (medscape.com)
• Shaping genes : ethics, law and science of using new genetic technology in medicine and agriculture / Darryl R. J. Macer. (who.int)
• The Soil and Health Association says a new gene-splitting technique must be defined as genetic engineering. (wordpress.com)
• Detailed information about genes and genetic conditions has been added to MedlinePlus, an online health and wellness resource from the National Library of Medicine (NLM). (medlineplus.gov)
• Here you can read straightforward information about genetic testing, gene therapy, and genetic research. (medlineplus.gov)
• MedlinePlus Genetics also includes articles on more than 1,400 genes and 1,300 genetic conditions. (medlineplus.gov)
• A curated database of genes associated with dietary restriction in model organisms either from genetic manipulation experiments or gene expression profiling. (senescence.info)
• Also, associations between accelerated decline in lung function and genetic variations in several genes which regulate inflammation were found in firefighters that can not be explained by smoking history. (cdc.gov)

Variants9

• Several transcript variants encoding different isoforms have been found for this gene. (nih.gov)
• They found a correlation between variants in a gene called the D4 receptor and the students' self-reports on sexuality. (livescience.com)
• The number of cards in the Finnish deck is fewer than the number of cards in the California deck because the Finns have fewer gene variants, or alleles, to play with. (discovermagazine.com)
• They found that those with the disease had variants of the genes PARK16, BST1, SNCA and LRRK2. (abc.net.au)
• In the second study, researchers led by Dr Andrew Singleton at the National Institutes of Health 's (NIH) laboratory of neurogenetics in the US analysed the genes of more than 5,000 patients of European ancestry who suffer from the disease and detected strong links between Parkinson's and variants of the genes SNCA and MAPT. (abc.net.au)
• Identifying the genes in which common variants play a role in ASD is difficult, however, and we have very few as yet. (nih.gov)
• Over 1000 pathogenic allelic variants of the gene have been identified. (medscape.com)
• In light of this, functional variants of these genes have been examined for evidence of association with pulmonary fibrosis in a group of ex-coal miners, accelerated decline in lung function in firefighters and irritant contact dermatitis in healthcare workers. (cdc.gov)
• Several significant associations appeared between cytokine gene variants and disease progress and/or severity. (cdc.gov)

Proteins12

• The SGCA gene provides instructions for making the alpha component (subunit) of a group of proteins called the sarcoglycan protein complex. (medlineplus.gov)
• Gene-P", the preformationist gene concept, serves as an instrumental predictor of phenotypic outcomes, while "Gene-D", the gene of epigenesis, is a developmental resource that specifies possible amino acid sequences for proteins. (mit.edu)
• Evolutionary conservation of genes is also an oxymoron-how can proteins manage to evolve by staying the same for millions of years? (creation.com)
• Good choices (and the proteins that are developed because of them) beget more good proteins, and the activation of bad genes begets more bad and destructive genes being turned on. (nationalgeographic.com)
• The looping mechanism serves to physically bring together a distant enhancer element with the start site of the targeted gene, allowing Mediator to recruit the proteins responsible for reading the gene to the location," Dr. Shiekhattar says. (genengnews.com)
• Genes are the blueprints the body's cells follow to produce proteins, and sometimes mutations in genes can lead to a change in the function of the protein they code. (yahoo.com)
• In the new research, scientists found mutations in the genes PADI3, TCHH , and TGM3 that code for important proteins involved in the formation of hair fibres. (yahoo.com)
• The Supreme Court decision describes synthetic BRCA1 and BRCA2 genes, made of something called cDNA, that have had the parts of their sequence removed that don't code for proteins. (popsci.com)
• RNA plays versatile roles in the transcription and translation of genes into proteins. (dkfz.de)
• A cascade effect occurs when ras -GTPase is "switched on" by incoming signals, leading to activation of other proteins, which, in turn, activate genes responsible for cell growth and differentiation. (medscape.com)
• Mutations in ras genes can cause permanent activation of ras proteins. (medscape.com)
• This domain occurred 318 times on human genes ( 726 proteins). (umbc.edu)

Scientists22

• To test the notion of whether bees have personality, scientists led by entomologist Gene Robinson of the University of Illinois at Urbana-Champaign focused on scout bees that embark on reconnaissance missions for food. (sciencenews.org)
• The scientists looked at several genes previously linked to impulsivity and substance use. (eurekalert.org)
• These noncoding RNA-activators (ncRNA-a) have a crucial role in turning genes on and off during early embryonic development, the scientists say, and have also been connected with diseases including some cancers in adults. (genengnews.com)
• Scientists think coloboma is caused by changes in the genes that control eye development. (nih.gov)
• Scientists have found some of the genes that can cause coloboma. (nih.gov)
• The OHSU Gene Profiling Shared Resource is a full-service genomics facility providing research scientists and clinicians with services for RNA expression profiling, DNA variation analysis, and nucleic acid extraction. (ohsu.edu)
• The genes linked with left-handedness result in differences in brain structure, the scientists found. (cnn.com)
• Your sexual desire or lack thereof could be in your genes, scientists announced today. (livescience.com)
• Scientists debunk the 'gay gene' argument and conclude that environmental factors have twice as much impact as genetics. (lifesitenews.com)
• The people in this land of lakes and forests are so alike that scientists can filter out the genes that contribute to heart disease, diabetes, and asthma. (discovermagazine.com)
• Scientists have found the genes responsible for "uncombable hair syndrome", a rare condition that makes it almost impossible to tame some people's hair. (yahoo.com)
• In the new study, published recently in the journal Jama Dermatology , scientists assessed one of the largest worldwide data collections of affected individuals, and have found the spectrum of genes involved in the condition. (yahoo.com)
• A gene variant that scientists already knew to be associated with longer life also seems to make people smarter, and may help offset the effects of normal cognitive decline in old age, according to a team of San Francisco researchers. (sfgate.com)
• In a study of more than 700 people ages 52 to 85, the scientists found that those with the gene variant performed better on a variety of cognitive tests than those without it. (sfgate.com)
• In this type of gene therapy, scientists use retroviruses, of which HIV is an example. (scientificamerican.com)
• Scientists have discovered a single gene that could provide vital clues to treating age-related hearing disabilities affecting approximately 50 percent of people over the age of 60, across the world. (ibtimes.com)
• During the research, the scientists found that mice without the FGF20 gene had approximately two-thirds of their outer hair cells missing. (ibtimes.com)
• The scientists are testing the gene therapy in non-human primates. (medicalnewstoday.com)
• Patients and scientists are heading to federal court to challenge a company's right to a monopoly on diagnostic tests for genes linked to hereditary breast and ovarian cancer. (womensenews.org)
• Using state-of the-art, next generation DNA sequencing technology, the scientists initially found a defect in the MEGF10 gene for a large family living in the UK. (leeds.ac.uk)
• According to scientists dermatoglyphics proved that is a very useful tool for identification of various gene-linked abnormalities and many human diseases. (sospublication.co.in)
• However, single cell gene expression profiling, and its close cousin single nucleus gene expression, are now helping scientists make significant progress in understanding the causes and pathogenesis of these disorders and may someday lead to effective treatments. (10xgenomics.com)

Researchers30

• The researchers extracted the DNA from mouse primordial germ cells - the precursors to sperm and eggs - at various stages of their development and used markers to spot any methylated genes. (newscientist.com)
• The researchers then looked at what genes were active in brain tissue of scouts and nonscouts. (sciencenews.org)
• The activity of a gene related to dopamine in the scout bees was dialed way down, the researchers found, suggesting they may be less averse to new experiences. (sciencenews.org)
• Studying adolescent twins, the researchers found that genes linked to the brain's serotonin and kappa opioid receptors -- neuronal receptors associated with mood, depression and addiction -- also play a role in whether a person will choose an immediate reward over a more sizeable payoff later. (eurekalert.org)
• Long segments of noncoding RNA are key to physically manipulating DNA in order to activate certain genes, say researchers at The Wistar Institute. (genengnews.com)
• This image is an example of the kind of gel pictures researchers use to understand the order, or sequence, of genes or to look for mutations in genes. (cancer.org)
• One approach researchers are using to identify women at risk for TNBC and possible treatment options for TNBC is by studying inherited changes (mutations) in cancer genes. (cancer.org)
• A team of researchers in Rochester, Minnesota recently discovered mutations in 5 genes that seem to increase the risk for TNBC. (cancer.org)
• In the past, researchers weren't able to find other breast cancer risk genes, because the technology was too complicated to check the genes in large numbers of people, Couch says. (cancer.org)
• A protein the researchers named "Kipferl" plays a decisive role in ensuring the effective control of jumping genes. (oeaw.ac.at)
• Central to their findings is an uncharacterized protein that the researchers named "Kipferl", which ensures the effective control of jumping genes. (oeaw.ac.at)
• Researchers have determined that a gene present in mouse cells limits the number of times that a cell can divide. (news-medical.net)
• The researchers said the gene, known as SIRT1, suppresses longevity, and may play a role in regulating the aging process. (news-medical.net)
• The researchers began studying SIRT1 because they were intrigued by published reports from other research groups that showed that the yeast version of the gene, Sir2, extends the ability of cells to replicate. (news-medical.net)
• To confirm that it was only suppression of SIRT1 that affected the cells, and not some secondary effect caused by knocking out the gene early in development, the researchers created mouse cells in which they could switch off the gene at will. (news-medical.net)
• Interview With A Gene Research Written by Jon Rappoport Category: Articles Published: 01 April 2011 During my appearance on Coast to Coast AM, last Thursday, with George Noory, I described three interviews I had with gene researchers. (thenhf.com)
• John Yodder, professor from the University of California Davis and one of the researchers of the study added that they will identify critical parasite genes and pathways to use this information to develop parasite-resistant crops. (isaaa.org)
• The researchers used phylogenomic approaches to search for orthologous genes (genes from different species that are derived from a common ancestral gene) that didn't have a known function among echinoderms. (cmu.edu)
• The researchers then used that dataset to identify genes that share an ancestral relationship across other marine animals such as sponges, anemones and sea squirts. (cmu.edu)
• To produce an adeno-associated virus that can carry a therapeutic gene and live on its own, researchers add innocuous DNA from adenovirus during preparation. (scientificamerican.com)
• In out-of-the-body gene therapy, researchers take blood or bone marrow from a patient and separate out immature cells. (scientificamerican.com)
• People of Japanese and European descent who have mutant versions of five genes may be at higher risk of developing Parkinson's disease, two large teams of researchers have found. (abc.net.au)
• Researchers have cleared a safety hurdle in efforts to develop a gene therapy for a form of muscular dystrophy that disables patients by gradually weakening muscles near the hips and shoulders. (sun-sentinel.com)
• Described as the first gene therapy trial in muscular dystrophy to demonstrate promising findings, researchers from the University of Florida, Nationwide Children's Hospital in Columbus, Ohio, and The Ohio State University report how they safely transferred a gene to produce a protein necessary for healthy muscle fiber growth into three teenagers with limb-girdle muscular dystrophy. (sun-sentinel.com)
• CINCINNATI -- Cincinnati Children's Hospital Medical Center researchers, working in collaboration with researchers from the University of Cincinnati (UC) Academic Health Center at the Computational Medicine Center, have established a powerful new gene information resource designed to aid biomedical researchers in more effectively identifying small alterations in the human genome that are associated with individuals' susceptibility to disease. (cincinnatichildrens.org)
• Researchers at Cambridge found that about 25% of Labs have a gene variant that makes them constantly crave food, reports the Guardian . (newser.com)
• To reveal them, researchers at the Max Planck Institutes of Molecular Cell Biology and Genetics and for the Physics of Complex Systems as well as the Center for Systems Biology Dresden systematically searched for genes that were lost in the ancestor of today's whales and dolphins. (mpg.de)
• That's why a team of Dresden researchers around Michael Hiller together with colleagues from the University of California and the American Museum of Natural History in New York carried out a systematic search for genes that got lost during this evolutionary transition. (mpg.de)
• To this end, the researchers examined the genomes of today's whales, dolphins and other mammals for mutations that inactivate genes. (mpg.de)
• Interestingly, the researchers found that all genes required to produce melatonin, the hormone that regulates sleep, have been lost in whales and dolphins. (mpg.de)

Genetics12

• Genetics research studies how individual genes or groups of genes are involved in health and disease. (cdc.gov)
• Newborn screening tests and BRCA gene testing are among those genetics tests currently administered by experts. (go.com)
• Genes & Health is one of the world's largest community-based genetics studies, aiming to improve health among people of Pakistani and Bangladeshi heritage by analysing the genes and health of 100,000 local people. (genesandhealth.org)
• Lifestyle and genetics are intertwined, in that your lifestyle choices influence the ways that many of your genes function-and thus how your body functions. (nationalgeographic.com)
• It's a ''potential'' of our genes, or maybe even a ''natural anomaly'' if that makes any sense, but is not directly linked to what would construct man's evolutionary genetics, although sadly I'm convinced that everything happens for a reason, even such disgusting things. (answerbag.com)
• The ruling found a middle ground, saying that Myriad Genetics, which is based in Utah, can't actually patent the naturally occurring genes BRCA1 and BRCA2. (popsci.com)
• Many academic labs, including our own, will soon be offering panel tests for dozens, or even hundreds of genes, for the same price Myriad historically charged for just two genes," Kenneth Offit, chief of the clinical genetics service at Memorial Sloan-Kettering Cancer Center, told the New York Times . (popsci.com)
• While the Supreme Court ruled that naturally occurring genes aren't patentable, it nevertheless upheld Myriad Genetics' patents on synthetic versions of BRCA1 and BRCA2 that are chemically different from how they appear in human cells. (popsci.com)
• Like Myriad Genetics, those companies had the exclusive right to offer tests for those genes. (popsci.com)
• The safety data is accumulating because this is the same type of vector that we and other research groups have successfully used in gene therapy trials for other diseases," said Dr. Barry Byrne, a UF pediatric cardiologist who is a member of the UF Genetics Institute and director of the Powell Gene Therapy Center. (sun-sentinel.com)
• Myriad Genetics, a company based in Salt Lake City, holds patents that prohibit anyone else from developing alternative diagnostic tests for the BRCA genes. (womensenews.org)
• Professor David H. Ledbetter, director of the division of medical genetics at Emory University in Atlanta and a plaintiff in the lawsuit, said gene patents create monopolies that deprive patients such as Girard of a second opinion in the form of an alternative diagnostic test and testing laboratory. (womensenews.org)

Genome9

• The idea of the gene has been a central organizing theme in contemporary biology, and the Human Genome project and biotechnological advances have put the gene in the media spotlight. (mit.edu)
• Finally, Moss draws on the findings of the Human Genome Project, biological modularity, and the growing interest in resynthesyzing theories of evolution and development to look beyond the "century of the gene" toward a rebirth of biological understanding. (mit.edu)
• Think of the human genome as a very large deck of cards, each card bearing a gene variant. (discovermagazine.com)
• Starfish and humans, along with other vertebrates, share a number of similarities in their early development, genome organization and gene content. (cmu.edu)
• The total number of genes in a genome is not a driver, this value varies only slightly in multicellular animals, so we looked for other factors. (port.ac.uk)
• Gene duplication, although the total number of genes in the genome doesn't vary significantly, some specific genes duplicate one or more times, for example there is one NCoR gene in sea urchin and two in humans. (port.ac.uk)
• In April, as the world marks the 50th anniversary of Watson and Crick's Nobel Prize-winning description of the DNA double helix, the National Institute of Environmental Health Sciences will look beyond the historic sequencing of the human genome to new and future studies of how variations in our genes can interact with the environment to cause disease. (nih.gov)
• About 20 percent of all genes in the human genome are patented, giving owners of the patents property rights over gene sequences. (womensenews.org)
• Targeted sequencing of the S gene, using either NGS or Sanger sequencing, or whole genome sequencing using NGS will provide positive identification of Omicron. (who.int)

Mutation13

• Dominant diseases can be caused by only one copy of a gene having a DNA mutation . (cdc.gov)
• For recessive diseases, both copies of a gene must have a DNA mutation in order to get one of these diseases. (cdc.gov)
• It is caused by a mutation in a gene found on chromosome 11. (cdc.gov)
• If your pup always acts like they're hungry-no matter how much you feed them-the POMC gene mutation could be to blame. (wisdompanel.com)
• If your pup has always had a voracious appetite, their genes-or a mutation of the pro-opiomelanocortin (POMC) gene, to be precise-might actually be to blame. (wisdompanel.com)
• The POMC gene mutation is an autosomal dominant disorder. (wisdompanel.com)
• According to the study that discovered the POMC gene mutation , about one in five Labrador Retrievers carry it. (wisdompanel.com)
• Test your pup for the POMC gene mutation. (wisdompanel.com)
• Imagine for a moment that you were offered the chance to know every gene mutation that you and your family have in your DNA. (go.com)
• The most common SGCA gene mutation occurs in about one-third of people with limb-girdle muscular dystrophy type 2D. (medlineplus.gov)
• The NF1 gene locus has a higher spontaneous mutation rate than do most gene loci. (medscape.com)
• The NF1 phenotype is highly penetrant (ie, almost all individuals with an NF1 gene mutation have some phenotypic traits of the syndrome). (medscape.com)
• Sequencing of the neuraminidase gene showed that the resistant viruses contained an H275Y mutation, and S247N was also identified in the neuraminidase gene of one seasonal influenza A(H1N1) virus that exhibited enhanced resistance. (who.int)

Protein21

• This change in sequence can change the way that the gene works, for example by changing the protein that is made. (cdc.gov)
• The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). (nih.gov)
• A highly-similar gene encoding a related protein is also found on chromosome 1. (nih.gov)
• One such doppelganger gene codes for a protein called the Signal Recognition Particle 14 (SRP14), which has a poly-alanine C-terminus. (creation.com)
• 2 For example, the gene which codes the protein prestin, which plays a role in echolocation, is expressed in the inner ear of whales and bats. (creation.com)
• For example, after implementing changes to their physical activity, stress management, and diet regimens, men were able to turn off genes associated with prostate cancer growth and turn on a gene that produced a protein that causes cancer cells to self-destruct. (nationalgeographic.com)
• Here, using in vivo chromatin immunoprecipitation sequencing in mouse kidney, we demonstrate that PTH activation rapidly induces increased recruitment of phosphorylated (p-133) CREB (pCREB) and its coactivators, CBP (CREB-binding protein) and CRTC2 (CREB-regulated transcription coactivator 2), to previously defined kidney-specific M1 and M21 enhancers near the Cyp27b1 gene. (jbc.org)
• According to their findings, ncRNA-a molecules bind to large protein complexes to form a loop of DNA, which then opens up the gene to the molecular machinery that transcribes DNA. (genengnews.com)
• They found that depleting components of the protein complex known as Mediator specifically and potently diminished the ability of ncRNA-a to start the process of transcribing a gene into RNA. (genengnews.com)
• We found a set of genes whose functions are unknown, and they don't have any known protein domains," Foley said. (cmu.edu)
• Single genes often make more than one protein. (port.ac.uk)
• The messenger RNA (mRNA) that links gene to protein can be processed by 'splicing' to generate a range of different mRNAs, each of which encodes a related, but different protein. (port.ac.uk)
• Because they have had their non-protein-coding portions removed, you can think of them as "cleaned-up" versions of the genes. (popsci.com)
• The protein encoded by this gene is a member of the fibroblast growth factor family which plays a key role in various biological processes like embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (ibtimes.com)
• The volunteers encountered no adverse health events, and the transferred genes continued to produce the needed protein for at least six months after treatment. (sun-sentinel.com)
• The RefSeq Genes track shows known C. elegans protein-coding and non-protein-coding genes taken from the NCBI RNA reference sequences collection (RefSeq). (ucsc.edu)
• By default, both the protein-coding and non-protein-coding genes are displayed. (ucsc.edu)
• This could allow patent owners to have exclusive rights to perform diagnostic tests, determine whether a new drug could be an effective treatment or to insert a gene that supplies a healthy protein to cure a disease. (womensenews.org)
• The NF1 gene product is a cytoplasmic protein called neurofibromin 1, which appears to have diverse functions in many different tissues. (medscape.com)
• CRISPR gene editing is used to remove a gene from immune T cells that encodes a protein called PD-1 that tumor cells can use to evade an immune attack. (who.int)
• Knowledge of the genes involved, the function of their protein products, and of their interaction with the relevant environmental influences does however have the potential to illuminate disease mechanisms at the molecular level and provide new opportunities to treat and prevent it. (cdc.gov)

BRCA15

• Because of her family history, Golkin-Nigliazzo was tested after her diagnosis for mutations on the BRCA1 and BRCA2 genes, which increase the risk of breast and ovarian cancers in women. (cnn.com)
• About 10 to 15% of triple-negative breast cancers in Caucasians test positive for mutations in the BRCA1 gene. (cancer.org)
• Until recently, BRCA1 was the only gene linked to TNBC. (cancer.org)
• After BRCA1 and BRCA2 , PALB2 is the next important gene that will define risk for breast cancer, he added. (medscape.com)
• While we know the risks associated with BRCA1 and BRCA2 , we do not know the risk for breast cancer associated with other genes," Dr. Evans told Medscape Medical News . (medscape.com)

Diseases7

• Genes & Health is a research study set up to help fight against these and other major diseases. (genesandhealth.org)
• Over the past decades, the discovery of the genes involved in autoinflammatory syndromes together with the insights into their innate immune mechanisms have revolutionized the paradigm of definition, classification and therapeutical approach of the different autoinflammatory diseases. (frontiersin.org)
• The lack of adverse events seen in this trial not only supports gene therapy for this disease, but it also supports such therapies for many other diseases. (sun-sentinel.com)
• Genes associated with health and diseases are patented more often than others, according to an October 2005 report in the academic research journal Science. (womensenews.org)
• Sequencing of all virulence gene am- ( speM , ssa ), which are strongly associated with severe plicons was performed with the same primers used for am- diseases such as scarlet fever, streptococcal toxic shock plifi cation (STAB-Vida, Lisbon, Portugal). (cdc.gov)
• Cytokine gene polymorphisms and susceptibility to chronic inflammatory diseases in occupational settings. (cdc.gov)
• Recent evidence suggests that common polymorphisms in immune/inflammatory and antioxidant genes contribute to the pathogenesis of many complex human diseases. (cdc.gov)

Search2

• This systematic search revealed 85 gene losses. (mpg.de)
• A new method of inserting genes into brain cells could greatly simplify the search for brain-disorder treatments, according to research reported this month. (ieee.org)

Certain genes2

• Coloboma happens when certain genes send the wrong instructions, so the eyes don't develop correctly. (nih.gov)
• In this case, testing might indicate the presence of certain genes that are causing that person to have a higher pain perception. (medscape.com)

Individual genes1

• Although we all have the same genes, individual genes vary slightly in each of us, making some of us far more susceptible to environmental insults and chemicals than others are. (nih.gov)

Chromosomes4

• People get (inherit) their chromosomes , which contain their genes , from their parents. (cdc.gov)
• Their findings also provide a plausible mechanism of how locations along chromosomes, known as enhancer elements, can influence the expression of genes located 5,000 to 100,000 base pairs of DNA away. (genengnews.com)
• The structural chromosome alterations may arise at the chromosome level (e.g., translocations and gains or losses of large portions of chromosomes) or at the nucleotide level, which influence gene structure or expression such as mutations, insertions, deletions, gene amplifications, and gene silencing by epigenetic effects ( Jefford and Irminger-Finger, 2006 ). (frontiersin.org)
• Some are caused by changes in genes or chromosomes. (cdc.gov)

Virulence Genes1

• Virulence Genes of Lansing, MI, USA). (cdc.gov)

Therapies5

• Early in-the-body gene therapies used a virus called adenovirus-the virus behind the common cold-but the agent can cause an immune response from the body, putting a patient at risk of further illness. (scientificamerican.com)
• In-the-body gene therapies often take advantage of the natural tendency of viruses to infect certain organs. (scientificamerican.com)
• Because blood-clotting factors can be added to the blood in the liver, this virus is used in gene therapies to treat hemophilia. (scientificamerican.com)
• Claire has worked with a range of clients in the biotechnology and pharmaceutical areas, on applications related to a broad range of technologies, including antibodies, industrial biotechnology, gene therapies, RNA therapies, new chemical entities and drug repurposing. (appleyardleesgreenshoots.com)
• Here's why gene therapies are the most expensive drugs in the world-and how these groundbreaking treatments could severely strain our health care system. (medscape.com)

Content1

• I think the No. 1 thing we can do with whole genomes is study gene content with much greater precision. (batcon.org)

20161

• Here is the full list of Scientific Publications from Genes & Health since 2016. (genesandhealth.org)

Found16

• . Escherichia coli ( E. coli ) bacteria carrying the mcr-1 gene were found in a urine sample from a person in Pennsylvania with no recent travel outside of the United States who presented to a clinic with a urinary tract infection. (cdc.gov)
• The SGCA gene is found on chromosome 17 . (medlineplus.gov)
• Doppelganger genes are genes that are highly homologous to one another but are found on disjunct parts of the alleged evolutionary tree. (creation.com)
• In contrast, analogous genes are found in unrelated organisms, and have the same function, albeit with totally different structures. (creation.com)
• First, they found that serotonin genes were involved. (eurekalert.org)
• In a recent publication of the journal Genomics , Carnegie Mellon University researcher Saoirse Foley and colleagues found 14 genes that could provide insight into the origins of marine life. (cmu.edu)
• What we found was there are no lineage-specific echinoderm genes," Foley said. (cmu.edu)
• Three echinoderm species were found to have all 14 of the genes: a sea lily (Anneissia japonica), the crown-of-thorns starfish (Acanthaster planci) and purple urchins (Strongylocentrotus purpuratus). (cmu.edu)
• The fact that the genes are so old and found only in marine organisms suggests that they are at least performing a marine-specific function," she said. (cmu.edu)
• Studies from the late 1990s, when the gene variant was discovered, found that people with the variant tend to live about five years longer than others, and in animals, the effect is even more profound. (sfgate.com)
• 4 At least part of this increased risk appears to be due to the fact that new mutations-especially mutations that disrupt the function of genes-are found more often in the sperm of older men. (nih.gov)
• For example, a variety of Turkish wheat, collected and stored in a seed gene bank in 1948, was rediscovered in the 1980s, when it was found to carry genes resistant to many types of disease-causing fungi. (fao.org)
• Michael Hiller, who oversaw this study, concludes: "We found new evidence that loss of genes during evolution can sometimes be beneficial, which supports previous results from our lab suggesting that gene loss is an important evolutionary mechanism. (mpg.de)
• All but 1 of the PCR products showed expected sizes (on- terminants ( tet genes) have been found among streptococ- line Appendix Table). (cdc.gov)
• The team found 692 events in 513 unique differentially expressed genes. (10xgenomics.com)
• Just two months after their autism study was published, the team published another article in Nature describing a single cell study of multiple sclerosis (MS). They found that neurons are differentially vulnerable to damage from MS lesions and that the most dysregulated genes in the disease appear in upper cortical neurons and certain reactive glial cells located on the edge of MS lesions in the subcortex (2). (10xgenomics.com)

Therapeutic2

• Beyond muscular dystrophy, the discovery shows muscle tissue can be an effective avenue to deliver therapeutic genes for a variety of muscle disorders, including some that are resistant to treatment, such as inclusion body myositis, and in conditions where muscle is atrophied, such as in cancer and aging. (sun-sentinel.com)
• The Engineered Therapeutic Group of Chemical Biology & Therapeutics (CBT) at Novartis Institutes for BioMedical Research (NIBR) in Cambridge, MA, has made key contributions to a novel CRISPR based gene therapy for SCD which is currently in Phase I clinical trials. (novartis.com)

Chromosome3

• If the gene is on the X chromosome, the disorder is called X-linked. (cdc.gov)
• It is caused by a change in a gene on the X chromosome. (cdc.gov)
• The NF1 gene is cytogenetically located on the long (q) arm of chromosome 17, at band 11.2 (17q11.2). (medscape.com)

Receptor2

• Serotonin genes and kappa opioid receptor genes are connected to mood. (eurekalert.org)
• There are multiple ways in which resistance can occur, but one common way in ER+/HER2- breast cancer is the development of mutations in a gene that codes for the estrogen receptor (ESR1). (stopbreastcancer.org)

Orphanet1

• Orphanet is part of the Gene Curation Coalition, a global effort to harmonise gene-level resources. (orpha.net)

RefSeq1

• Please visit the Feedback for Gene and Reference Sequences (RefSeq) page to make suggestions, submit additions and corrections, or ask for help concerning RefSeq records. (ucsc.edu)

Susceptibility4

• These genes are known by several names: breast-cancer-risk genes, cancer-predisposition genes, and cancer-susceptibility genes. (cancer.org)
• The results of this study suggest that polymorphic genotypes within the GST gene cluster and MnSOD do not affect individual susceptibility to PMF. (cdc.gov)
• Polymorphic genes may increase susceptibility or resistance to disease but do not determine it. (cdc.gov)
• The identification of a single polymorphic gene alone is therefore unlikely to provide the basis for a screening test for susceptibility to OA. (cdc.gov)

Genomes4

• Learn about genes, genomes and health. (genesandhealth.org)
• By reconstructing the evolutionary history of every gene in these genomes one can not only find global evolutionary patterns but also identify remarkable exceptions, as we did here," said Gabaldón. (cmu.edu)
• As we get better and better genomes, we understand that evolution through gene duplication and gene loss is important. (batcon.org)
• To understand more about gene families (sets of similar genes) that are critical for immunity and sensory systems in mammals, we need really good whole genomes to study. (batcon.org)

Regulate3

• We expected to identify genes that interacted directly with DNA to regulate other genes, but this was not the case. (port.ac.uk)
• The antioxidant enzymes glutathione S-transferases (GST) and manganese superoxide dismutase (MnSOD) are important components of lung defence against oxidative stress, and polymorphisms in the genes which regulate their expression may represent important disease modifiers. (cdc.gov)
• Key genes were overrepresented in L2/3 and L4 (all upper levels of the cortex) excitatory neurons, as well as VIP- and somatostatin-expressing interneurons, which set daily cellular rhythms and regulate endocrine functions, respectively. (10xgenomics.com)

Good Genes2

• Ariana Richards -- Good Genes or Good Docs? (tmz.com)
• They've got good genes. (insideyouthsports.org)

Family of genes1

• For example, the gradual transformation of one family of genes to another has never been observed, indeed it cannot even be observed. (creation.com)

Idea that genes2

• Moss argues that the popular idea that genes constitute blueprints for organisms is the result of an unwarranted conflation of these independently valid senses of the gene, and he analyzes the rhetorical basis of this conflation. (mit.edu)
• But the idea that genes carrying these epigenetic markings could be inherited is controversial. (newscientist.com)

Expression of ge1

• The epigenetic regulation of expression of genes involved in the absorption, distribution, metabolism, and excretion (ADME) of drugs contributes to interindividual variability in drug response. (nih.gov)

Patents on genes2

• Companies, universities and others hold more than 4,000 U.S.-granted patents on genes, representing some 40 percent of human DNA, Reuters reported . (popsci.com)
• The case could go all the way to the U.S. Supreme Court, with far-reaching implications for patents on genes associated with asthma, colon cancer, Alzheimer's disease and many other illnesses. (womensenews.org)

Hundreds of genes1

• The latest estimates suggest that hundreds of genes contribute to the likelihood of developing ASD. (nih.gov)

Thousands of genes2

• These methods enable us to sequence hundreds or even thousands of genes at the same time for an affordable price. (leeds.ac.uk)
• The -technique's inventor thinks it could be the key to examining thousands of genes for answers to vexing -neurological problems, with the hope of one day -performing gene therapy in the brain. (ieee.org)

Sequence4

• For example, suppose part of a gene usually has the sequence TAC. (cdc.gov)
• The de novo appearance of genes from random non-coding sequence has also never been observed. (creation.com)
• Gene Codes has released Sequencher 5.3, the latest version of its sequence analysis software. (genomeweb.com)
• A single transcript chosen for a gene which is the most conserved, most highly expressed, has the longest coding sequence and is represented in other key resources, such as NCBI and UniProt. (ensembl.org)

Evolution6

• Several genes were duplicated during human evolution. (nature.com)
• 4 describe the evolutionary history and function of the human gene SRGAP2 and provide evidence for molecular and cellular mechanisms that may link the gene's evolution with that of our brain. (nature.com)
• Figure 1: Evolution and function of a human gene. (nature.com)
• Evolution has difficulty explaining the similarities in gene distribution and sequences in unrelated groups of organisms. (creation.com)
• Big question: why hasn't evolution weeded out the genes that cause this common, deadly condition in the human heart system? (axios.com)
• This means that evolution cannot invent new genes from nothing. (theness.com)

Health3

• Is our health only written in our genes? (medscape.com)
• Click here to read about the latest updates from Genes & Health. (genesandhealth.org)
• Hear what local people think about Genes & Health, and see inside the Blizard Institute and The Centre Of The Cell. (genesandhealth.org)

Humans5

• Some of these genes relate to the same molecular pathways implicated in novelty-seeking in humans. (sciencenews.org)
• Nonmarine animals such as humans, flies or mice had none of the genes. (cmu.edu)
• The variation observed among humans on Earth, such as in physical features, including hair colour, texture, and style, is due to small variations in genes between people. (yahoo.com)
• Genes which determine animal complexity - or what makes humans so much more complex than a fruit fly or a sea urchin - have been identified for the first time. (port.ac.uk)
• For example, the sea urchin gene produces just one type of RNA while in humans the NCoR2 gene produces well over 30 and each is likely to have a different function. (port.ac.uk)

Therapy18

• Gene therapy in ophthalmology is a fast moving and promising field. (mednet.nl)
• How does gene therapy work? (scientificamerican.com)
• Gene therapy is the addition of new genes to a patient's cells to replace missing or malfunctioning genes. (scientificamerican.com)
• Doctors are working on the ability to do out-of-the-body gene therapy to replace all of a patient's bone marrow or the entire blood system, as would be useful in sickle-cell anemia-in which red blood cells are shaped like crescents, causing them to block the flow of blood. (scientificamerican.com)
• Out-of-the-body gene therapy has already been used to treat severe combined immunodeficiency-also referred to as SCID or boy-in-the-bubble syndrome-where patients are unable to fight infection and die in childhood. (scientificamerican.com)
• Although there are currently no gene therapy products on the market in the U.S., recent studies in both Parkinson's disease and Leber congenital amaurosis, a rare form of blindness, have returned very promising results. (scientificamerican.com)
• Diabetes: Can gene therapy normalize blood glucose levels? (medicalnewstoday.com)
• Dr. Gittes and team demonstrated that in a mouse model of diabetes, blood glucose levels were restored for about 4 months with gene therapy. (medicalnewstoday.com)
• The viral gene therapy appears to create these new insulin-producing cells that are relatively resistant to an autoimmune attack," explains Dr. Gittes. (medicalnewstoday.com)
• AAV vectors are currently being researched in human gene therapy trials and could be delivered to the pancreas through a non-surgical endoscopic procedure, eventually. (medicalnewstoday.com)
• A clinical trial in both type 1 and type 2 diabetics in the immediate foreseeable future is quite realistic, given the impressive nature of the reversal of the diabetes, along with the feasibility in patients to do AAV gene therapy. (medicalnewstoday.com)
• We think this is an important milestone in establishing the successful use of gene therapy in muscular dystrophy," said Dr. Jerry Mendell, director of the Center for Gene Therapy in The Research Institute at Nationwide Children's Hospital and the lead author of the study. (sun-sentinel.com)
• These exciting results demonstrate the feasibility of gene therapy to treat limb-girdle muscular dystrophy," said Jane Larkindale, portfolio director with Muscular Dystrophy Association Venture Philanthropy, a program that moves basic research into treatment development. (sun-sentinel.com)
• This particular type of gene therapy gave mice younger bodies and 30% longer lifespans. (bigthink.com)
• IMSEAR at SEARO: Gene therapy. (who.int)
• Saksena S, Dasarathy S. Gene therapy. (who.int)
• Is $3.5 Million a Fair Price for a Lifesaving Gene Therapy? (medscape.com)
• If the intension is to keep this pandemic going for 100 more years, you keep vaccinating the public using these mRNA gene therapy vaccines in the exact same way. (rumormillnews.com)

CRISPR2

• This is a truly unacceptable development," said Jennifer Doudna , a UC Berkeley scientist and one of the inventors of the CRISPR gene-editing tool that He said he used. (sfgate.com)
• Jennifer Doudna , Gene Editing, and the Future of the Human Race , by Walter Isaacson This book is about one of the most important scientific advances of the last decade: The CRISPR gene editing system. (sfgate.com)

Breast and ovarian1

• It doesn't make sense that a company could patent a part of the body,' said Girard, a plaintiff in a lawsuit charging that patents on the two genes associated with breast and ovarian cancer are unconstitutional and invalid. (womensenews.org)

Genomic1

• Alt and his colleagues have been exploring the entire seven-member family of SIRT genes because of their potential regulatory roles in the immune system, genomic stability and DNA repair. (news-medical.net)

Simmons10

• It's no secret KISS frontman Gene Simmons is not a fan of hip-hop music. (vibe.com)
• Kiss frontman Gene Simmons is at the center of controversy yet again for his frank, and what some might deem inflammatory comments about Prince 's unexpected death. (vibe.com)
• Gene Simmons is back at it again with rude comments against the hip-hop community. (vibe.com)
• Kiss 's next four concerts have been postponed because Gene Simmons has tested positive for COVID-19, just five days after the band had to cancel a show because Paul Stanley had tested positive . (variety.com)
• While Paul Stanley recently tweeted that he has recovered from COVID, Gene Simmons has now tested positive and is experiencing mild symptoms. (variety.com)
• Kiss co-founder, reality television star and entrepreneur Gene Simmons will be the Keynote Q&A for the fifth annual Billboard Touring Conference, set for Nov. 19-20 at the Roosevelt Hotel in New York. (hollywoodreporter.com)
• The Q&A will be filmed for an episode of his A&E reality show "Gene Simmons Family Jewels," now in its third season. (hollywoodreporter.com)
• Gene Simmons' fingerprints are on virtually all segments of the music industry, particularly as it relates to the live music business," Waddell said. (hollywoodreporter.com)
• We are thrilled to have him onboard for our milestone fifth Touring Conference and we know his insight and the 'Gene Simmons world view' will be a compelling must-see for our attendees. (hollywoodreporter.com)
• His other businesses include a line of T-shirts and accessories called Gene Simmons Moneybag, the Simmons Comic Group, Simmons Records and his publishing imprint Simmons Books, which published his best-selling "Sex Money Kiss" and "Ladies of the Night. (hollywoodreporter.com)

Turn genes1

• Development is orchestrated by regulatory elements that turn genes ON or OFF in precise patterns. (mdpi.com)

Activate1

• The enzymes produced by SIRT genes, called deacetylases, activate a wide range of target molecules. (news-medical.net)

MRNA2

• Riboswitches are 5′-untranslated regions of mRNA that change their conformation in response to ligand binding, allowing post-transcriptional gene regulation. (jbc.org)
• And Dr. Alexander said, if someone was to asked him, if you wanted to create a bioweapon today that harm and slow kill the population, I would say, implement these mRNA gene platforms exactly like this. (rumormillnews.com)

Enzymes1

• Genes can be switched off by altering DNA through a chemical process called methylation, in which enzymes respond to environmental factors by marking genes with methyl groups that prevent them from working. (newscientist.com)

1,0002

• We saw massive differences in over 1,000 genes," says Robinson. (sciencenews.org)
• A small cottage industry of firms will soon sell the ability to map your genes for around $1,000, Shirley Wang reports on Lunch Break. (wsj.com)

Polymorphisms3

• Lack of association between antioxidant gene polymorphisms and progressive massive fibrosis in coal miners. (cdc.gov)
• None of the individual investigated polymorphisms and two-way gene-gene interactions had a statistically significant association with PMF. (cdc.gov)
• Differences between individuals in their responses are likely to be determined, at least in part, by the functional consequences of polymorphisms of relevant genes, and their interactions with each other. (cdc.gov)

Interactions1

• To understand the complexity of gene function and interactions, a large amount of data has to be generated systematically by high-throughput automated systems. (medscape.com)

Function10

• This gene may function to capture immune complexes in the peripheral circulation. (nih.gov)
• Doppelganger genes perform the same function and have highly similar structures, appearing in two distinct clades far from one another on the alleged evolutionary tree. (creation.com)
• To discover how such enhancer-like RNAs function, Dr. Shiekhatter's laboratory deleted candidate molecules with known roles in activating gene expression, and assessed if they were related to RNA-dependent activation. (genengnews.com)
• It is at least one answer to how these classical enhancer elements function while being physically distant from their target genes. (genengnews.com)
• As we learn more about noncoding RNA, I believe we will have a profoundly better understanding of how our genes function," says Dr. Shiekhattar, a Herbert Kean, M.D., family professor and senior author of the study. (genengnews.com)
• Many of these genes were probably lost because their function was no longer useful. (mpg.de)
• The MEGF10 gene normally plays an important function in muscle stem cells. (leeds.ac.uk)
• The NF1 phenotype results from loss-of-function mutations of the NF1 gene and, therefore, the absence of neurofibromin 1. (medscape.com)
• We use the NCBI Pubtator API function to identify human genes and names for PubMed records. (cdc.gov)
• In addition, the majority of the most up-regulated genes were those associated with metastasis and earlier recurrence, whereas the genes for normal liver function were substantially down-regulated in H-JNK1 HCC tissue. (cdc.gov)

Metabolism1

• The company said the test looks for genes that affect metabolism. (reuters.com)

Evolutionary3

• The distribution of genes and their sequential similarities and differences challenge evolutionary theory. (creation.com)
• Doppelganger genes pose a serious problem to evolutionary theory. (creation.com)
• The same, or very similar, sequences of mutations would have had to occur in different DNA sequences in two different branches of the evolutionary tree to produce two genes that are very homologous to one another. (creation.com)

Study9

• A research study identified new genes that may be associated with a higher risk for triple-negative breast cancer. (cancer.org)
• The next step would be to study some of the 14 genes in a laboratory setting to try to discover their functions. (cmu.edu)
• The study is a paradigm of how to gather the kind of information that clinicians need to advise their patients about the meaning of mutations in these genes," Mark E. Robson, MD, told Medscape Medical News . (medscape.com)
• In the first study, Dr Tatsushi Toda of Japan's Kobe University and colleagues sequenced the genes of 2,011 participants with the disease and 18,381 others without the disease. (abc.net.au)
• The study also looked at the relative divergence times for language and genes for related populations. (theness.com)
• This study involves a comprehensive, multi-modal, and integrative assessment of biomarkers implicated in the pathophysiology of PTSD, including measuring differences in whole-blood gene expression and other blood biomarkers of key neurobiological systems, an approach critical to informing risk and resilience prediction algorithms for PTSD, and to develop novel psychopharmacologic approaches for the treatment of this disabling condition in disaster responders and other trauma survivors. (cdc.gov)
• To estimate the prevalence of thalassaemia genes in Baghdad, a study was made of 502 randomly selected pregnant women attending a major maternity care clinic in the city. (who.int)
• PHILADELPHIA - A new study provides important new insights into gene-driven perceptions of pain. (medscape.com)
• Results: In the present study, we reported HCC signature genes based on the JNK1 activation status in 31 HCC specimens relative to the matched distal noncancerous liver tissue from 31 patients. (cdc.gov)

Phenotype1

• 1] Patients with NF1 who have a whole NF1 gene deletion (about 4-5% of individuals with NF1) appear to develop a more severe phenotype than do patients with a partial gene deletion. (medscape.com)

Cancer9

• In the heart of the book, Moss uses the Gene-D/Gene-P distinction to examine the real basis of biological order and of the pathological loss of order in cancer. (mit.edu)
• He reviews the history of cancer research with an emphasis on the oncogene and tumor suppressor gene models and shows how these gene-centered strategies point back to the significance of higher level, multi-cellular organizational fields in the onset and progression of cancer. (mit.edu)
• The same principle applies for colon and breast cancer: Lifestyle changes switched on genes that fought cancer and turned off genes that promoted it. (nationalgeographic.com)
• The Gene Profiling Shared Resource receives support from the OHSU Knight Cancer Institute NCI Cancer Center Support Grant P30CA069533. (ohsu.edu)
• However, the SIRT1-deficient cells had a normal senescence response when exposed to high-level oxidation or the activated cancer gene, Ras. (news-medical.net)
• There is now evidence that mutations in the PALB2 gene are associated with a significantly increased risk for breast cancer in women. (medscape.com)
• How does the Supreme Court's ruling on synthetic genes affect breast cancer risk testing? (popsci.com)
• It turns out that they're part of Myriad's breast cancer gene test. (popsci.com)
• Likewise, hypoxic breast cancer cells showed higher propensity to increase expression of oncogenes and to decrease expression of tumor suppressor genes ( Jefford and Irminger-Finger, 2006 ). (frontiersin.org)

Human gene1

• Studies of human gene expression show that if you choose to make certain lifestyle changes, you can influence whether your genes are "on" or "off. (nationalgeographic.com)

BRCA3

• Until the patents expire in 2014 and 2015, its laboratory is the only place in the country where diagnostic testing for the BRCA genes can be performed. (womensenews.org)
• The cost of developing alternative diagnostic tests for the BRCA genes would be 'relatively trivial,' probably not exceeding several tens of thousands of dollars, Ledbetter estimated. (womensenews.org)
• Ledbetter said he would conduct research to develop an alternative diagnostic test if Myriad's BRCA genes patents were invalidated. (womensenews.org)

Disease9

• If one parent has the disease, each child has a 50% chance of inheriting the mutated gene. (cdc.gov)
• If both parents have one copy of the mutated gene, each child has a 25% chance of having the disease, even though neither parent has it. (cdc.gov)
• For example, sickle cell disease is an autosomal single gene disorder. (cdc.gov)
• The disease is caused by mutations in either of two ATP-binding cassette (ABC) half-transporters, ABCG5 or ABCG8 , but the exact role of these genes in the trafficking of sterols has been unclear. (the-scientist.com)
• Use these social-bookmarking links to share Five genes linked to Parkinson's disease . (abc.net.au)
• Talks on DNA variation in gene-environment interaction research and its implications to human disease will be presented. (nih.gov)
• Among the life science judges were Jennifer Doudna , the pioneer gene editing researcher at UC Berkeley, and Shinya Yamanaka of UCSF's Gladstone Institute of Cardiovascular Disease. (sfgate.com)
• To obtain more information on each disease, click on the link to the gene symbol which leads to NCBI Gene . (cdc.gov)
• The risk of developing the disease if a first-degree relative is affected is 5% to 10% greater than the prevalence of the disease in the population, but less than the 25% risk for a recessive and 50% risk for a dominant single gene disorder. (cdc.gov)

Tumor1

• in both conditions, however, the altered gene products have an important role in the dysregulation of tumor suppression. (medscape.com)

Plasmid3

• The mcr-1 gene exists on a plasmid, a small piece of DNA that is capable of moving from one bacterium to another, potentially spreading antibiotic resistance to other bacterial species. (cdc.gov)
• In November 2015, a report from China first described plasmid-mediated colistin-resistance caused by the mcr-1 gene. (cdc.gov)
• The presence of the mcr-1 gene on a plasmid means that colistin resistance can be shared with other more resistant bacteria such as CRE, raising the possibility that untreatable bacteria could develop. (cdc.gov)