Carbolines: A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.SulfonesSelf-Help Groups: Organizations which provide an environment encouraging social interactions through group activities or individual relationships especially for the purpose of rehabilitating or supporting patients, individuals with common health problems, or the elderly. They include therapeutic social clubs.Purines: A series of heterocyclic compounds that are variously substituted in nature and are known also as purine bases. They include ADENINE and GUANINE, constituents of nucleic acids, as well as many alkaloids such as CAFFEINE and THEOPHYLLINE. Uric acid is the metabolic end product of purine metabolism.PiperazinesOnline Systems: Systems where the input data enter the computer directly from the point of origin (usually a terminal or workstation) and/or in which output data are transmitted directly to that terminal point of origin. (Sippl, Computer Dictionary, 4th ed)Phosphodiesterase Inhibitors: Compounds which inhibit or antagonize the biosynthesis or actions of phosphodiesterases.Phosphodiesterase 5 Inhibitors: Compounds that specifically inhibit PHOSPHODIESTERASE 5.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Erectile Dysfunction: The inability in the male to have a PENILE ERECTION due to psychological or organ dysfunction.Pharmacies: Facilities for the preparation and dispensing of drugs.ArgentinaDrugs, Generic: Drugs whose drug name is not protected by a trademark. They may be manufactured by several companies.Pharmaceutical Services, Online: Pharmacy services accessed via electronic means.Legislation, Pharmacy: Laws and regulations, pertaining to the field of pharmacy, proposed for enactment or enacted by a legislative body.Counterfeit Drugs: Drugs manufactured and sold with the intent to misrepresent its origin, authenticity, chemical composition, and or efficacy. Counterfeit drugs may contain inappropriate quantities of ingredients not listed on the label or package. In order to further deceive the consumer, the packaging, container, or labeling, may be inaccurate, incorrect, or fake.Quality of Life: A generic concept reflecting concern with the modification and enhancement of life attributes, e.g., physical, political, moral and social environment; the overall condition of a human life.3',5'-Cyclic-GMP Phosphodiesterases: Enzymes that catalyze the hydrolysis of cyclic GMP to yield guanosine-5'-phosphate.Penis: The external reproductive organ of males. It is composed of a mass of erectile tissue enclosed in three cylindrical fibrous compartments. Two of the three compartments, the corpus cavernosa, are placed side-by-side along the upper part of the organ. The third compartment below, the corpus spongiosum, houses the urethra.Drug Prescriptions: Directions written for the obtaining and use of DRUGS.Prescription Drugs: Drugs that cannot be sold legally without a prescription.Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.Penile Erection: The state of the PENIS when the erectile tissue becomes filled or swollen (tumid) with BLOOD and causes the penis to become rigid and elevated. It is a complex process involving CENTRAL NERVOUS SYSTEM; PERIPHERAL NERVOUS SYSTEMS; HORMONES; SMOOTH MUSCLES; and vascular functions.Pharmacy: The practice of compounding and dispensing medicinal preparations.Education, Pharmacy: Formal instruction, learning, or training in the preparation, dispensing, and proper utilization of drugs in the field of medicine.Schools, Pharmacy: Educational institutions for individuals specializing in the field of pharmacy.Directories as Topic: Lists of persons or organizations, systematically arranged, usually in alphabetic or classed order, giving address, affiliations, etc., for individuals, and giving address, officers, functions, and similar data for organizations. (ALA Glossary of Library and Information Science, 1983)Newspapers: Publications printed and distributed daily, weekly, or at some other regular and usually short interval, containing news, articles of opinion (as editorials and letters), features, advertising, and announcements of current interest. (Webster's 3d ed)Logistic Models: Statistical models which describe the relationship between a qualitative dependent variable (that is, one which can take only certain discrete values, such as the presence or absence of a disease) and an independent variable. A common application is in epidemiology for estimating an individual's risk (probability of a disease) as a function of a given risk factor.Mass Media: Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.Transportation: The means of moving persons, animals, goods, or materials from one place to another.Motor Vehicles: AUTOMOBILES, trucks, buses, or similar engine-driven conveyances. (From Random House Unabridged Dictionary, 2d ed)Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Prolactinoma: A pituitary adenoma which secretes PROLACTIN, leading to HYPERPROLACTINEMIA. Clinical manifestations include AMENORRHEA; GALACTORRHEA; IMPOTENCE; HEADACHE; visual disturbances; and CEREBROSPINAL FLUID RHINORRHEA.Dictionaries, PharmaceuticErgolines: A series of structurally-related alkaloids that contain the ergoline backbone structure.Hyperprolactinemia: Increased levels of PROLACTIN in the BLOOD, which may be associated with AMENORRHEA and GALACTORRHEA. Relatively common etiologies include PROLACTINOMA, medication effect, KIDNEY FAILURE, granulomatous diseases of the PITUITARY GLAND, and disorders which interfere with the hypothalamic inhibition of prolactin release. Ectopic (non-pituitary) production of prolactin may also occur. (From Joynt, Clinical Neurology, 1992, Ch36, pp77-8)Commerce: The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)Questionnaires: Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.Hospital-Physician Joint Ventures: A formal financial agreement made between one or more physicians and a hospital to provide ambulatory alternative services to those patients who do not require hospitalization.Insurance, Pharmaceutical Services: Insurance providing for payment of services rendered by the pharmacist. Services include the preparation and distribution of medical products.Meptazinol: A narcotic antagonist with analgesic properties. It is used for the control of moderate to severe pain.Prescription Drug Misuse: Improper use of drugs or medications outside the intended purpose, scope, or guidelines for use. This is in contrast to MEDICATION ADHERENCE, and distinguished from DRUG ABUSE, which is a deliberate or willful action.Men's Health: The concept covering the physical and mental conditions of men.Amitriptyline: Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.Chlordiazepoxide: An anxiolytic benzodiazepine derivative with anticonvulsant, sedative, and amnesic properties. It has also been used in the symptomatic treatment of alcohol withdrawal.Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.Thailand: Formerly known as Siam, this is a Southeast Asian nation at the center of the Indochina peninsula. Bangkok is the capital city.Amoxicillin: A broad-spectrum semisynthetic antibiotic similar to AMPICILLIN except that its resistance to gastric acid permits higher serum levels with oral administration.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Carbidopa: An inhibitor of DOPA DECARBOXYLASE, preventing conversion of LEVODOPA to dopamine. It is used in PARKINSON DISEASE to reduce peripheral adverse effects of LEVODOPA. It has no antiparkinson actions by itself.Dementia: An acquired organic mental disorder with loss of intellectual abilities of sufficient severity to interfere with social or occupational functioning. The dysfunction is multifaceted and involves memory, behavior, personality, judgment, attention, spatial relations, language, abstract thought, and other executive functions. The intellectual decline is usually progressive, and initially spares the level of consciousness.DibenzothiazepinesRenal Aminoacidurias: A group of inherited kidney disorders characterized by the abnormally elevated levels of AMINO ACIDS in URINE. Genetic mutations of transport proteins result in the defective reabsorption of free amino acids at the PROXIMAL RENAL TUBULES. Renal aminoaciduria are classified by the specific amino acid or acids involved.Nose Neoplasms: Tumors or cancer of the NOSE.Prednisone: A synthetic anti-inflammatory glucocorticoid derived from CORTISONE. It is biologically inert and converted to PREDNISOLONE in the liver.
Levitra and cialis both are PDE5 inhibitors and in which way do they differ in performance, price, customer satisfaction, Any clarifications please? alongside the clarifications information regrading more drug ingeractions if any would be important,does it have any effect on the bone marrow? - Preceding unsigned comment added by 175.110.134.250 (talk) 08:48, 11 September 2011 (UTC) Levitra is not used much, so studies comparing "customer satisfaction" have been done between the more widely used Cialis and Viagra, and have not shown much difference. The main difference between the 3 drugs (Levitra, Viagra, and Cialis) is the duration of action/pharmacologic half-life of Cialis, which is mentioned in the article. Levitra and Cialis have similar pharmacologic properties (half-life, duration of action, time of onset) and efficacy, with Cialis being more widely used due to "first to market" and familiar ...
... was originally approved by the U.S. Food and Drug Administration (FDA) on February 9, 2000,[1] after a seven-month review.[2] At the time of the initial approval U.S. Food and Drug Administration (FDA) reviewers found that alosetron improved symptoms in 10% to 20% of patients.[3] Shipment to pharmacies started in March, 2000. On July 17, a health professional filed a report with the FDA on the death of a 50-year-old woman who suffered mesenteric ischemia. The report identified alosetron as the "primary suspect" in the death.[4] Alosetron was withdrawn from the market voluntarily by GlaxoWellcome on November 28, 2000 owing to the occurrence of serious life-threatening gastrointestinal adverse effects, including 5 deaths and additional bowel surgeries.[2] The FDA said it had reports of 49 cases of ischemic colitis and 21 cases of "severe constipation" and that ten of the 70 patients underwent surgeries and 34 others were examined at hospitals and released without surgery. Through ...
One of pinoline's most outstanding pharmacological properties is its ability to promote neurogenesis in vitro; even at trace concentrations.[6] Aluminium toxicity causes an increase in lipid peroxidation, with most damage occurring in the brain. A recent review of studies shows pinoline and melatonin to be effective at reducing the lipid peroxidation. Studies included both human and animal subjects. The studies' results support that pinoline has antioxidant properties.[7] Lipopolysaccharide is produced by Gram-negative bacteria and stimulates the production of free radicals which in turn cause lipid peroxidation. A recent study compared the effectiveness of melatonin and other similar compounds on the lipopolysaccharide induced lipid peroxidation. The results showed support for pinoline's ability to reduce damage from lipid peroxidation. Pinoline was also shown to be more effective than vitamin E at reducing lipopolysaccharide activity in the retina.[8] Another recent study compared the ...
Tadalafil je organsko jedinjenje, koje sadrži 22 atoma ugljenika i ima molekulsku masu od 389,404 Da.[1][2][3] Cialis (tadalafil) tablete opuštaju mišiće koji se nalaze u zidovima krvnih sudova, i povećava protok krvi u pojedinim delovima tela. Cialis se kao terapija koristi za lečenje erektilne disfunkcije (impotencije) i u slučajevima benigne hipertrofije, to jest, uvećanja prostate. Kod fiziološke erekcije penisa pomaže tako što iz corpus cavernusum oslobađa azot monoksid (NO), koji zatim aktivira enzim gvanilat ciklazu, koji je ključni enzim u sintezi ciklicnog guanozin monofosfata (cGMP). cGMP nakon toga u velikoj meri relaksira glatke mišiće corpus cavernusum, i na taj način povećava dotok krvi i intrakavernozni pritisak, sto u suštini igra najvažniju ulogu u erekciji kod muškaraca. ...
... is a weak partial inverse agonist of the benzodiazepine class of drugs, developed by Hoffmann-La Roche in the 1980s. It acts as a competitive antagonist, and can therefore be an antidote to the acute impairment caused by alcohol. Ro15-4513 is structurally related to the benzodiazepine antidote flumazenil. The main interest in Ro15-4513 was as an antidote to alcohol. Flumazenil effectively blocks the effects of benzodiazepine agonists such as alprazolam and diazepam and so is used for treating overdoses of these drugs but is ineffective in blocking alcohol actions. Ro15-4513 was somewhat less effective than flumazenil at blocking the effects of benzodiazepines, but instead selectively blocked the effects of ethanol. This meant that in contrast to flumazenil, which is ineffective at treating alcohol overdoses, Ro15-4513 showed potential as a useful alcohol antidote. It is thought that Ro15-4513 antagonizes the effects of ethanol because the azido group at the 8- position of the benzene ...
The FDA's approval of sildenafil in 1998[16] was a ground-breaking commercial event for the treatment of ED, with sales exceeding US$1 billion. Subsequently, the FDA approved vardenafil in 2003,[17] and tadalafil in 2003. It initially was developed by the biotechnology company ICOS, and then again developed and marketed worldwide by Lilly ICOS, LLC, the joint venture of ICOS Corporation and Eli Lilly and Company. Tadalafil was approved in 2009 in the United States for the treatment of pulmonary arterial hypertension[18] and is under regulatory review in other regions for this condition. In late November 2008, Eli Lilly sold the exclusive rights to commercialize tadalafil for pulmonary arterial hypertension in the United States to United Therapeutics for an upfront payment of $150 million. Tadalafil was discovered by Glaxo Wellcome (now GlaxoSmithKline) under a partnership between Glaxo and ICOS to develop new drugs that began in August 1991.[19][20] In 1993, the Bothell, Washington biotechnology ...
Heterocyclic amines are a group of chemical compounds, many of which can be formed during cooking. They are found in meats that are cooked to the "well done" stage, in pan drippings and in meat surfaces that show a brown or black crust. Epidemiological studies show associations between intakes of heterocyclic amines and cancers of the colon, rectum, breast, prostate, pancreas, lung, stomach/esophagus and animal feeding experiments support a causal relationship. The U.S. Department of Health and Human Services Public Health Service labeled several heterocyclic amines as likely carcinogens in its 13th Report on Carcinogens. Changes in cooking techniques reduce the level of heterocyclic amines. More than 20 compounds fall into the category of heterocyclic amines, often abbreviated HCAs[1]. Table 1 shows the chemical name and abbreviation of those most commonly studied. All four of these compounds are included in the 13th Report on Carcinogens. The compounds found in food are formed when creatine (a ...
PDE5 je enzim koji vezuje cGMP i razlaže ga. Inhibitori ovog enzima: sildenafil, vardenafil i tadalafil se vezuju za PDE5 katalitičko mesto. Iz kinetičkih merenja vezivanja inhibitora i inhibicije katalize proizilazi da postoje dva PDE5 konformera. To potvrđuju rezultati elektroforeze u gelu. Smatra se da postoji izduženi i kompaktni konformer. PDE5 aktivnost je modulisana brzim reverzibilnim redoks prekidačom. Promena redukcionog stanja enzima, ili izolovanog regulatornog domena, je povezana sa konformacionom promenom sličnom promeni koja je izazvana fosforilacijom. PDE5 je izražen u ljudskim ćelijama debelog creva i u intestinalnom tkivu. Njegova aktivnost je regulisana intracelularnim cGMP nivoima. Smatra se da do toga dolazi putem cGMP vezivanja za GAF domene PDE5 N-terminusa, što dovodi do alosterne aktivacije enzima. ...
... is a name that can be given to any herbal product advertised as treating erectile dysfunction. There are many different products advertised as herbal viagra, but with varying ingredients. There are no clinical trials or scientific studies that support the effectiveness of any of these ingredients for the treatment of erectile dysfunction and some products have been found to contain drugs and other adulterants, and have been the subject of FDA and FTC warnings and actions to remove them from the market. The name "herbal viagra" is taken from the brand name Viagra, under which drug company Pfizer sells sildenafil citrate, a drug that is used to treat erectile dysfunction. Viagra has become a generic term for many people discussing drugs designed to treat erectile dysfunction, even those which do not contain sildenafil. Herbal viagras, contrary to what the name suggests, do not normally contain sildenafil citrate. However, sildenafil and chemicals similar to sildenafil have been found ...
In the US even though sildenafil is available only by prescription from a doctor, it was advertised directly to consumers on TV (famously being endorsed by former United States Senator Bob Dole and football star Pelé). Numerous sites on the Internet offer Viagra for sale after an "online consultation", often a simple web questionnaire.[51][52] The Viagra name has become so well known, many fake aphrodisiacs now call themselves "herbal viagra" or are presented as blue tablets imitating the shape and colour of Pfizer's product. Viagra is also informally known as "vitamin V", "the blue pill", or "blue diamond", as well as various other nicknames. In 2000, Viagra sales accounted for 92% of the global market for prescribed erectile dysfunction pills.[53] By 2007, Viagra's global share had plunged to about 50%[54] due to several factors, including the entry of Cialis and Levitra, along with several counterfeits and clones, and reports of vision loss in people taking PDE5 ...
Pored erektilne disfunkcije, sildenafil citrat je takođe efektivana u lečenju retke bolesti pulmonalne arterijske hipertenzije (PAH). On relaksira arterijske zidove, što dovodi do umanjenog pulmonalnog arterijskog otpora i pritiska. Time se smanjuje opterećenja desne komore srca i poboljšavaju simptomi desnostrane srčane insuficijencije. Pošto je PDE-5 primarno rasprostranjen unutar arterijskog zida glatkih mišića pluća i penisa, sildenafil deluje selektivno u te dve oblasti bez indukovanja vazodilatacije u drugim delovima tela. Pfizer je podneo zahtev za dodatnu registraciju sildenafila kod FDA, i sildenafil je odobren za tu indikaciju juna 2005. Preparat je nazvan Revatio, da bi se izbegla zabuna sa Viagrom, i tablete od 20 miligrama su bele i okrugle. Sildenafil se pridružuje bosentanu i na prostaciklin zasnovanim terapijama za ovo oboljenje.[5] ...
Pored erektilne disfunkcije, sildenafil citrat je takođe efektivana u lečenju retke bolesti pulmonalne arterijske hipertenzije (PAH). On relaksira arterijske zidove, što dovodi do umanjenog pulmonalnog arterijskog otpora i pritiska. Time se smanjuje opterećenja desne komore srca i poboljšavaju simptomi desnostrane srčane insuficijencije. Pošto je PDE-5 primarno rasprostranjen unutar arterijskog zida glatkih mišića pluća i penisa, sildenafil deluje selektivno u te dve oblasti bez indukovanja vazodilatacije u drugim delovima tela. Pfizer je podneo zahtev za dodatnu registraciju sildenafila kod FDA, i sildenafil je odobren za tu indikaciju juna 2005. Preparat je nazvan Revatio, da bi se izbegla zabuna sa Viagrom, i tablete od 20 miligrama su bele i okrugle. Sildenafil se pridružuje bosentanu i na prostaciklin zasnovanim terapijama za ovo oboljenje.[5] ...
PDE5 je enzim koji vezuje cGMP i razlaže ga. Inhibitori ovog enzima: sildenafil, vardenafil i tadalafil se vezuju za PDE5 katalitičko mesto. Iz kinetičkih merenja vezivanja inhibitora i inhibicije katalize proizilazi da postoje dva PDE5 konformera. To potvrđuju rezultati elektroforeze u gelu. Smatra se da postoji izduženi i kompaktni konformer. PDE5 aktivnost je modulisana brzim reverzibilnim redoks prekidačom. Promena redukcionog stanja enzima, ili izolovanog regulatornog domena, je povezana sa konformacionom promenom sličnom promeni koja je izazvana fosforilacijom. PDE5 je izražen u ljudskim ćelijama debelog creva i u intestinalnom tkivu. Njegova aktivnost je regulisana intracelularnim cGMP nivoima. Smatra se da do toga dolazi putem cGMP vezivanja za GAF domene PDE5 N-terminusa, što dovodi do alosterne aktivacije enzima. ...
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