The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
A highly conserved 76-amino acid peptide universally found in eukaryotic cells that functions as a marker for intracellular PROTEIN TRANSPORT and degradation. Ubiquitin becomes activated through a series of complicated steps and forms an isopeptide bond to lysine residues of specific proteins within the cell. These "ubiquitinated" proteins can be recognized and degraded by proteosomes or be transported to specific compartments within the cell.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
Databases devoted to knowledge about specific genes and gene products.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
The systematic study of the complete DNA sequences (GENOME) of organisms.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A system of safety management (abbreviated HACCP) applied mainly to the food industry. It involves the analysis and control of biological, chemical, and physical hazards, from raw material production, procurement and handling, to manufacturing, distribution and consumption of finished products.
Protein factors uniquely required during the initiation phase of protein synthesis in GENETIC TRANSLATION.
A peptide initiation factor that binds specifically to the 5' MRNA CAP STRUCTURE of MRNA in the CYTOPLASM. It is a component of the trimeric complex EIF4F.
Any method used for determining the location of and relative distances between genes on a chromosome.
Recording of regional electrophysiological information by analysis of surface potentials to give a complete picture of the effects of the currents from the heart on the body surface. It has been applied to the diagnosis of old inferior myocardial infarction, localization of the bypass pathway in Wolff-Parkinson-White syndrome, recognition of ventricular hypertrophy, estimation of the size of a myocardial infarct, and the effects of different interventions designed to reduce infarct size. The limiting factor at present is the complexity of the recording and analysis, which requires 100 or more electrodes, sophisticated instrumentation, and dedicated personnel. (Braunwald, Heart Disease, 4th ed)
Short tracts of DNA sequence that are used as landmarks in GENOME mapping. In most instances, 200 to 500 base pairs of sequence define a Sequence Tagged Site (STS) that is operationally unique in the human genome (i.e., can be specifically detected by the polymerase chain reaction in the presence of all other genomic sequences). The overwhelming advantage of STSs over mapping landmarks defined in other ways is that the means of testing for the presence of a particular STS can be completely described as information in a database.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
The time period of daily exposure that an organism receives from daylight or artificial light. It is believed that photoperiodic responses may affect the control of energy balance and thermoregulation.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
The region of the stem beneath the stalks of the seed leaves (cotyledons) and directly above the young root of the embryo plant. It grows rapidly in seedlings showing epigeal germination and lifts the cotyledons above the soil surface. In this region (the transition zone) the arrangement of vascular bundles in the root changes to that of the stem. (From Concise Dictionary of Biology, 1990)
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
Biological mechanism that controls CIRCADIAN RHYTHM. Circadian clocks exist in the simplest form in cyanobacteria and as more complex systems in fungi, plants, and animals. In humans the system includes photoresponsive RETINAL GANGLION CELLS and the SUPRACHIASMATIC NUCLEUS that acts as the central oscillator.
PLANTS, or their progeny, whose GENOME has been altered by GENETIC ENGINEERING.
Any of the hormones produced naturally in plants and active in controlling growth and other functions. There are three primary classes: auxins, cytokinins, and gibberellins.
Methods used in the diagnosis and treatment of behavioral, personality, and mental disorders.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
A multicomponent, ribonucleoprotein complex comprised of one of the family of ARGONAUTE PROTEINS and the "guide strand" of the one of the 20- to 30-nucleotide small RNAs. RISC cleaves specific RNAs, which are targeted for degradation by homology to these small RNAs. Functions in regulating gene expression are determined by the specific argonaute protein and small RNA including siRNA (RNA, SMALL INTERFERING), miRNA (MICRORNA), or piRNA (PIWI-INTERACTING RNA).
A family of RNA-binding proteins that has specificity for MICRORNAS and SMALL INTERFERING RNA molecules. The proteins take part in RNA processing events as core components of RNA-induced silencing complex.
Small double-stranded, non-protein coding RNAs, 21-25 nucleotides in length generated from single-stranded microRNA gene transcripts by the same RIBONUCLEASE III, Dicer, that produces small interfering RNAs (RNA, SMALL INTERFERING). They become part of the RNA-INDUCED SILENCING COMPLEX and repress the translation (TRANSLATION, GENETIC) of target RNA by binding to homologous 3'UTR region as an imperfect match. The small temporal RNAs (stRNAs), let-7 and lin-4, from C. elegans, are the first 2 miRNAs discovered, and are from a class of miRNAs involved in developmental timing.
Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.
A cell line derived from cultured tumor cells.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Substances that inhibit or prevent the proliferation of NEOPLASMS.
Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.
A genus of small, two-winged flies containing approximately 900 described species. These organisms are the most extensively studied of all genera from the standpoint of genetics and cytology.
A species of fruit fly much used in genetics because of the large size of its chromosomes.
Proteins that originate from insect species belonging to the genus DROSOPHILA. The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Small kinetoplastid mitochondrial RNA that plays a major role in RNA EDITING. These molecules form perfect hybrids with edited mRNA sequences and possess nucleotide sequences at their 5'-ends that are complementary to the sequences of the mRNA's immediately downstream of the pre-edited regions.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.
A type of chromosomal aberration involving DNA BREAKS. Chromosome breakage can result in CHROMOSOMAL TRANSLOCATION; CHROMOSOME INVERSION; or SEQUENCE DELETION.
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Any cell, other than a ZYGOTE, that contains elements (such as NUCLEI and CYTOPLASM) from two or more different cells, usually produced by artificial CELL FUSION.
Mayer, Gene. "Innate (Non-specific) Immunity". Microbiology and Immunology Online. Mosser DM, Edwards JP (2008). "Exploring the ... The non-specific immune response is an immediate antigen-independent response, however it is not antigen-specific. Non-specific ... The non-specific immune system involves cells to which antigens are not specific in regards to fighting infection. The non- ... Complement proteins are proteins that play a role in the non-specific immune responses alongside these non-specific immune ...
ISBN 0-8160-3398-6. Specific Schott, Timothy; Landsea, Christopher W.; Hafele, Gene; Lorens, Jeffrey; Taylor, Arthur; Thurm, ... Blake, Eric S. (2011-09-06). Tropical Cyclone Report - Hurricane Eugene (PDF) (Report). United States: National Hurricane ...
Gene. 263 (1-2): 131-40. doi:10.1016/S0378-1119(00)00583-7. PMID 11223251. "Entrez Gene: VPRBP Vpr (HIV-1) binding protein". ... Specific interaction with a cellular protein". The Journal of Biological Chemistry. 269 (22): 15577-82. PMID 8195203. Zhang S, ... Protein VPRBP is a protein that in humans is encoded by the VPRBP gene. VPRBP has been shown to interact with Merlin. GRCh38: ... Zhao LJ, Zhang S, Chinnadurai G (2002). "Sox9 transactivation and testicular expression of a novel human gene, KIAA0800". ...
Rowland GC, Lim PP, Glass RE (July 1992). "'Stop-codon-specific' restriction endonucleases: their use in mapping and gene ... Gelinas RE, Myers PA, Weiss GH, Roberts RJ, Murray K (August 1977). "A specific endonuclease from Brevibacterium albidum". J ... Heiter DF, Lunnen KD, Wilson GG (May 2005). "Site-specific DNA-nicking mutants of the heterodimeric restriction endonuclease R. ... Khosaka T, Sakurai T, Takahashi H, Saito H (February 1982). "A new site-specific endonuclease Bbei from Bifidobacterium breve ...
It directly impacts chromatin structure and can modulate gene transcription, or even completely silence or activate genes, ... Specific RNA methyltransferases are employed by cells to mark these on the RNA species according to the need and environment ... m5C plays a role to regulate gene transcription. m5C transferases are the enzymes that produce C5-methylcytosine in DNA at C-5 ... In addition to controlling the expression of certain genes, there are a variety of protein complexes, many with implications ...
The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result ... "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819-30. PMID 8895530. Suzuki Y, Yoshitomo-Nakagawa K, ... "Entrez Gene: KRT7 keratin 7". Leong, Anthony S-Y; Cooper, Kumarason; Leong, F Joel W-M (2003). Manual of Diagnostic Cytology (2 ... Keratin-7 is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are ...
Although this gene is named HNRNPAB in reference to its first cloning as an RNA binding protein with similarity to HNRNP A and ... October 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819-30. PMID 8895530. Lau PP, Zhu HJ, ... "Entrez Gene: HNRPAB heterogeneous nuclear ribonucleoprotein A/B". Khan FA, Jaiswal AK, Szer W (September 1991). "Cloning and ... Heterogeneous nuclear ribonucleoprotein A/B, also known as HNRPAB, is a protein which in humans is encoded by the HNRPAB gene. ...
cAMP-specific 3',5'-cyclic phosphodiesterase 4A is an enzyme that in humans is encoded by the PDE4A gene. The protein encoded ... Milatovich A, Bolger G, Michaeli T, Francke U (Mar 1994). "Chromosome localizations of genes for five cAMP-specific ... "PDE4A phosphodiesterase 4A, cAMP-specific ( Homo sapiens )". Entrez Gene. 2012-03-04. Retrieved 2012-04-02. Hansen RT, Conti M ... Pryzwansky KB, Madden VJ (Jun 2003). "Type 4A cAMP-specific phosphodiesterase is stored in granules of human neutrophils and ...
Mayer, Gene (2006). "Immunology - Chapter One: Innate (non-specific) Immunity". Microbiology and Immunology On-Line Textbook. ... Granulocytes are a category of white blood cells in the innate immune system characterized by the presence of specific granules ... Neutrophils have two types of granules; primary (azurophilic) granules (found in young cells) and secondary (specific) granules ...
Gene. 151 (1-2): 291-6. doi:10.1016/0378-1119(94)90673-4. PMID 7828893. "Entrez Gene: PWP1 PWP1 homolog (S. cerevisiae)". ... 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635-48. doi:10.1016/ ... Periodic tryptophan protein 1 homolog is a protein that in humans is encoded by the PWP1 gene. GRCh38: Ensembl release 89: ... 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149- ...
Glucosidase 2 subunit beta is an enzyme that in humans is encoded by the PRKCSH gene. This gene encodes the beta-subunit of ... 1996). "A pancreatic cancer-specific expression profile". Oncogene. 13 (8): 1819-30. PMID 8895530. Trombetta ES, Simons JF, ... "Entrez Gene: PRKCSH protein kinase C substrate 80K-H". Thornalley PJ (1999). "Cell activation by glycated proteins. AGE ... 1997). "A 3-Mb region for the familial hemiplegic migraine locus on 19p13.1-p13.2: exclusion of PRKCSH as a candidate gene. ...
Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes & ... Shi Y, Mosser DD, Morimoto RI (March 1998). "Molecular chaperones as HSF1-specific transcriptional repressors". Genes & ... and this cancer-specific HSF1 panel of genes has indicated poor prognosis in breast cancer. The ability of cancer cells to use ... the transcription factor that regulates heat shock gene expression". Genes & Development. 6 (7): 1153-64. doi:10.1101/gad.6.7. ...
"Entrez Gene: USP39 ubiquitin specific peptidase 39". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... U4/U6.U5 tri-snRNP-associated protein 2 is a protein that in humans is encoded by the USP39 gene. GRCh38: Ensembl release 89: ... 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ... 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149- ...
"Entrez Gene: USP47 ubiquitin specific peptidase 47". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace ... Ubiquitin carboxyl-terminal hydrolase 47 is an enzyme that in humans is encoded by the USP47 gene. GRCh38: Ensembl release 89: ... 2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome ... 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149- ...
"Entrez Gene: MicroRNA 146a". Retrieved 2012-01-27. Lagos-Quintana M, Rauhut R, Yalcin A, Meyer J, Lendeckel W, Tuschl T (April ... 2002). "Identification of tissue-specific microRNAs from mouse". Current Biology. 12 (9): 735-9. doi:10.1016/S0960-9822(02) ... MicroRNA 146a is a small non-coding RNA that in humans is encoded by the MIR146A gene. microRNAs (miRNAs) are short (20-24 nt) ... "The role of microRNA genes in papillary thyroid carcinoma". Proceedings of the National Academy of Sciences of the United ...
"Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific ... indicating that the genes originated from a common ancestor gene. Nonetheless, though both genes possess ten exons and nine ... Gene. 338 (2): 157-62. doi:10.1016/j.gene.2004.06.005. PMID 15315819. Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, ... that in humans is encoded by the PCK2 gene on chromosome 14. This gene encodes a mitochondrial enzyme that catalyzes the ...
Specific "Nationals Park". MLB Advanced Media, L.P. Retrieved 2008-11-15. "Nationals Franchise History". MLB ... The Expos' first manager was Gene Mauch, who managed for six seasons. Felipe Alou is the franchise's all-time leader in regular ... "Gene Mauch Managerial Record". Baseball-Reference. Sports Reference, LLC. Retrieved 2008-11-14. "Manager of the Year Award ...
"DB2 database -> does it continue to be platform-specific? (iSeries, LUW, z/OS)". Gene Cobb (March 2008). "Moving from OPNQRYF ... Technology Refreshes are delivered as optional PTFs for specific releases of the operating system which add new functionality ... the size of the address space and the specifics of I/O and persistence. This is accomplished through two interrelated ...
"Entrez Gene: SQLE squalene epoxidase". Nagai M, Sakakibara J, Wakui K, Fukushima Y, Igarashi S, Tsuji S, Arakawa M, Ono T (Aug ... Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11 ... In humans, squalene epoxidase is encoded by the SQLE gene. Several eukaryote genomes lack a squalene monooxygenase encoding ... Gene. 200 (1-2): 149-56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. Lu Y, Dollé ME, Imholz S, van 't Slot R, Verschuren ...
This gene (GRINL1A) is part of a complex transcript unit that includes the gene for GRINL1A combined protein (Gcom1). ... Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788-95 ... The Gcom1 gene uses an upstream promoter for transcription and also has multiple alternatively spliced variants. NMDA receptor ... "Entrez Gene: GRINL1A glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A". Maruyama K, Sugano S (1994). "Oligo-capping ...
BRCA1-A complex subunit MERIT40 is a protein that in humans is encoded by the BABAM1 gene. BABAM1 has been shown to interact ... Hartley JL, Temple GF, Brasch MA (Nov 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11 ... "Entrez Gene: HSPC142 HSPC142 protein". CS1 maint: discouraged parameter (link) Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa ... Human BABAM1 genome location and BABAM1 gene details page in the UCSC Genome Browser. Maruyama K, Sugano S (Jan 1994). "Oligo- ...
"Entrez Gene: CRELD1 cysteine-rich with EGF-like domains 1". Human CRELD1 genome location and CRELD1 gene details page in the ... Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788-95 ... Cysteine-rich with EGF-like domain protein 1 is a protein that in humans is encoded by the CRELD1 gene. Epidermal growth factor ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ...
2004). "A novel gene, RSD-3/HSD-3.1, encodes a meiotic-related protein expressed in rat and human testis". J. Mol. Med. 81 (6 ... Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788-95 ... "Entrez Gene: SPATA7 spermatogenesis associated 7". CS1 maint: discouraged parameter (link) Maruyama K, Sugano S (1994). "Oligo- ... Spermatogenesis-associated protein 7 is a protein that in humans is encoded by the SPATA7 gene. GRCh38: Ensembl release 89: ...
"Entrez Gene: ZMYND10 zinc finger, MYND-type containing 10". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788-95 ... Zinc finger MYND domain-containing protein 10 is a protein that in humans is encoded by the ZMYND10 gene. GRCh38: Ensembl ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
Ubiquitin-associated protein 1 is a protein that in humans is encoded by the UBAP1 gene. This gene is a member of the ubiquitin ... Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 ... "Entrez Gene: UBAP1 ubiquitin associated protein 1". Farazi Fard MA, Rebelo AP, Buglo E, Nemati H, Dastsooz H, Gehweiler I, et ... Qian J, Zhang XH, Yang JB, Wang JR, Zhang BC, Tang K, Li GY (2001). "Cloning and Expression Analysis of a Novel Gene, UBAP1, ...
U3 small nucleolar ribonucleoprotein protein IMP3 is a protein that in humans is encoded by the IMP3 gene. This gene encodes ... Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 ... "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". ... "Entrez Gene: IMP3 IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast)". Adams MD, Kerlavage AR, Fleischmann RD, Fuldner ...
Lang KM, Spritz RA (1985). "Cloning specific complete polyadenylylated 3'-terminal cDNA segments". Gene. 33 (2): 191-6. doi: ... Hemoglobin subunit epsilon is a protein that in humans is encoded by the HBE1 gene. The epsilon globin gene (HBE) is normally ... "Entrez Gene: HBE1 hemoglobin, epsilon 1". Clegg JB (1982). "Embryonic hemoglobin: sequence of the epsilon and zeta chains". Tex ... Tuan D, Solomon W, Li Q, London IM (1985). "The "beta-like-globin" gene domain in human erythroid cells". Proc. Natl. Acad. Sci ...
It was also reported to regulate alternate splicing of the CFTR gene and the apoA-II gene. In spinal motor neurons TDP-43 has ... Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 ... Gene Result Sephton CF, Cenik C, Kucukural A, Dammer EB, Cenik B, Han Y, Dewey CM, Roth FP, Herz J, Peng J, Moore MJ, Yu G ( ... In particular, TDP-43 is a splicing factor binding to the intron8/exon9 junction of the CFTR gene and to the intron2/exon3 ...
"Entrez Gene: ATG10 ATG10 autophagy related 10 homolog (S. cerevisiae)". Human ATG10 genome location and ATG10 gene details page ... Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788-95 ... Autophagy-related protein 10 is a protein that in humans is encoded by the ATG10 gene. GRCh38: Ensembl release 89: ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ...
"Entrez Gene: ECOP EGFR-coamplified and overexpressed protein". CS1 maint: discouraged parameter (link) Maruyama K, Sugano S ( ... Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788-95 ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1-2): 149- ...
These connections are, unlike most artificial neural networks, sparse and usually specific. It is not known how information is ... aims to construct a biophysically detailed simulation of a cortical column on the Blue Gene supercomputer. ... It is also unknown what the computational functions of these specific connectivity patterns are, if any. ... transmitted through such sparsely connected networks, although specific areas of the brain, such as the Visual cortex, are ...
See Gene Quinn, SCOTUS Blog founder asks Supreme Court to reconsider Mayo ruling in Sequenom v. Ariosa , IP Watchdog (Mar. 21, ... I]f the breadth of the claim is sufficiently limited to a specific application of the new law of nature discovered by the ...
An ISBN identifies a specific edition of a book. Any given title may therefore have a number of different ISBNs. See xISBN ... Find this book in the Eugene, Oregon Public Library catalog. * Find this book in the Multnomah County, Oregon Library catalog ... If you arrived at this page by clicking an ISBN link in a Wikipedia page, then the find links below search for the specific ... Important: Google Books and provide valuable information about a book, but they might not give you the specifics you ...
... in FGFR genes) and mutations that lead to loss of function (in TWIST genes).[38][39] Craniosynostosis is therefore likely the ... Specific suturesEdit. Sagittal craniosynostosis/scaphocephalyEdit. There are two surgical procedures which are commonly used to ... Gene Loeys-Dietz syndrome wide-set eyes • split uvula or cleft palate • arterial tortuosity • aortic root dilatation • ... In terms of syndromic craniosynostosis not only do FGFR3 and TWIST genes feature, but also FGFR1 and in particular FGFR2, which ...
Gene ontology. Molecular function. • transcription factor activity, sequence-specific DNA binding. • RNA polymerase II ... This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors ... consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on ... This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by expanding it.. *v ...
"Entrez Gene: NMT1 N-myristoyltransferase 1". Rajala RV, Datla RS, Moyana TN, et al. (2000). "N-myristoyltransferase". Mol. Cell ... characterization of a novel gut-specific N-myristoylated annexin". J. Cell Biol. 116 (2): 405-22. doi:10.1083/jcb.116.2.405. ... is an enzyme that in humans is encoded by the NMT1 gene. GRCh38: Ensembl release 89: ENSG00000136448 - Ensembl, May 2017 GRCm38 ...
There are a number of rare cases of diabetes that arise due to an abnormality in a single gene (known as monogenic forms of ... "other specific types of diabetes").[10][13] These include maturity onset diabetes of the young (MODY), Donohue syndrome, and ... Most cases of diabetes involve many genes, with each being a small contributor to an increased probability of becoming a type 2 ... All of these genes together still only account for 10% of the total heritable component of the disease.[41] The TCF7L2 allele, ...
遗传学:150330 鼠基因:96794 同源基因:41321 ChEMBL(英语:ChEMBL): 1293235 GeneCards: LMNA Gene. ... Early in mitosis, MPF phosphorylates specific serine residues in all three nuclear lamins, causing depolymerization of the ... Entrez Gene: LMNA lamin A/C.. *^ Capell BC, Collins FS. Human laminopathies: nuclei gone genetically awry. Nat. Rev. Genet. ... Lamin A/C gene and a related sequence map to human chromosomes 1q12.1-q23 and 10. Somat. Cell Mol. Genet. March 1993, 19 (2): ...
Dawkins, Richard (1989). The Selfish Gene. Oxford University Press. ISBN 978-0-19-929115-1. .. ... In its usage in the Wikipedia article, knife-edge conditions is referring to the fact that very rarely, only when a specific ... condition is met and, for instance, X, equals a specific value is there an equilibrium. ...
Berkowitz, S.A., Philo, J.S. Monitoring the Homogeneity of Adenovirus Preparations (a Gene Therapy Delivery System) Using ... The organelles can then be identified by testing for indicators that are unique to the specific organelles.[9] ...
positive regulation of gene expression. • cell-cell signaling. • hormone-mediated signaling pathway. • follicle-stimulating ... first proposal for the amino acid sequence of the hormone-specific, beta subunit (hFSHb)". J. Clin. Endocrinol. Metab. 39 (1): ... 1999). "Characterization of single-nucleotide polymorphisms in coding regions of human genes". Nat. Genet. 22 (3): 231-8. PMID ... 1997). "Delayed puberty and hypogonadism caused by mutations in the follicle-stimulating hormone beta-subunit gene". N. Engl. J ...
"Cross" (Eugene Novotney). The clave rhythm and clave concept have been used in some modern art music ("classical") compositions ... Novotney, Eugene N. (1998) "Thesis: The 3:2 Relationship as the Foundation of Timelines in West African Musics" (registration ... Another clave-based composition that has "gone global" is the snare drum suite "Cross" by Eugene D. Novotney. ...
It has a core set of 1553 genes, plus 154 genes in its virulome, which contribute to virulence and 176 genes that maintain a ... Zheng CJ, Sohn MJ, Kim WG (2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of ... For instance, the Xisco gene was recently described as a biomarker for PCR-based detection of S. pneumoniae and differentiation ... In S. pneumoniae, at least 23 genes are required for transformation. For a bacterium to bind, take up, and recombine exogenous ...
... encoded by the L gene, partially uncoats the nucleocapsid and transcribes the genes into positive-strand mRNAs, which are then ... Their life cycle is thought to begin with a virion attaching to specific cell-surface receptors such as C-type lectins, DC-SIGN ... For more about specific outbreaks, see List of Ebola outbreaks.. The disease typically occurs in outbreaks in tropical regions ... Possible non-specific laboratory indicators of EVD include a low platelet count; an initially decreased white blood cell count ...
They are labelled "Type I" if the defective gene is for an enzyme involved in the assembly or transfer of the Glc3Man9GlcNAc2- ... clinical presentations and specific therapies". Eur. J. Pediatr. 162 (6): 359-79. doi:10.1007/s00431-002-1136-0. PMID 12756558. ...
a b c d e Eugene Kiely, Medicaid Estate Recovery Program,, Annenberg Public Policy Center, University of ... The annual cost of care will vary state to state depending on state approved Medicaid benefits, as well as the state specific ... Empirical studies have found that specific demographic characteristics of AFDC recipients also affect voters' perceptions of ... with no state-specific variations and a prohibition on asset or resource tests.[63] ...
... without references to a specific timeframe or locale, is sometimes used with an implication that most humans shared a certain ... "Chimps, Humans 96 Percent the Same, Gene Study Finds". Retrieved 23 December 2013 ...
Gene content and protein synthesisEdit. The chloroplast genome most commonly includes around 100 genes[7][10] which code for a ... The chloroplast editosome substitutes C -, U and U -, C at very specific locations on the transcript. This can change the codon ... 3 Gene content and protein synthesis *3.1 Chloroplast genome reduction and gene transfer ... Chloroplasts may contain 60-100 genes whereas cyanobacteria often have more than 1500 genes in their genome.[27] Contrarily, ...
These gene candidates include certain variations in tumor necrosis factor-alpha (TNF-alpha), IL-1 alpha, and CYP1A1 genes, ... Light therapy is a treatment method that involves delivering certain specific wavelengths of light to an area of skin affected ... Genes[edit]. Acne appears to be strongly inherited; genetics explain 81% of the variation in the population.[15] Studies ... There are specific sub-strains of C. acnes associated with normal skin and others with moderate or severe inflammatory acne.[50 ...
The former employee also revealed very specific instructions were given to them in terms of how to talk with callers and they ... Some of Tilton's fundraising letters were written by Gene Ewing, who heads a multimillion-dollar marketing empire writing ...
feed(lactose):-make(permease),make(galactosidase). make(Enzyme):-code(Gene,Enzyme),express(Gene). express(lac(X)):-amount( ... can be applied to select specific abductive explanations of the problem G. ... Like all enzymes, these are made if they are coded by a gene (Gene) that is expressed (described by the second rule). The two ... in a cluster of genes (lac(X)) - called an operon - that is expressed when the amounts (amt) of glucose are low and lactose are ...
with an amidation at the C-terminus.[4] Substance P is released from the terminals of specific sensory nerves. It is found in ... organization of the gene, chromosome localization, and functional expression of cDNA clones". Biochemistry. 30 (44): 10640-6. ... Substance P and the NK1 receptor are widely distributed in the brain and are found in brain regions that are specific to ... Huston JP, Hasenöhrl RU, Boix F, Gerhardt P, Schwarting RK (1993). "Sequence-specific effects of neurokinin substance P on ...
The HLA genes fall in two categories (Type I and Type II). In general, mismatches of the Type-I genes (i.e. HLA-A, HLA-B, or ... People who would like to be tested for a specific family member or friend without joining any of the bone marrow registry data ... as members of the same ethnic group are more likely to have matching genes, including the genes for HLA.[24] ... A mismatch of an HLA Type II gene (i.e. HLA-DR, or HLA-DQB1) increases the risk of graft-versus-host disease. In addition, a ...
Two genes, LAC12 and LAC4, allow K. marxianus to absorb and use lactose as a carbon source.[5] This species is considered to be ... The balance between respiration and fermentation metabolisms is strain specific.[5] This species also ferments inulin, glucose ... Using 18S rRNA gene sequencing, it was suggested that K. marxianus, K. aestuarii, K. dobzhanskii, K. lactic, K. wickerhamii, K ... marxianus possesses the necessary genes to be crabtree positive.[5] K. marxianus is highly thermotolerant and able to withstand ...
Some genes may have two alleles with equal distribution. For other genes, one allele may be common, and another allele may be ... As discussed above, "zygosity" can be used in the context of a specific genetic locus (example[5]). In addition, the word " ... Hemizygosity is also observed when one copy of a gene is deleted, or in the heterogametic sex when a gene is located on a sex ... A cell is said to be homozygous for a particular gene when identical alleles of the gene are present on both homologous ...
The specific coupling between the protein components of the cell cycle control network and the downstream readout of the ... The Caulobacter CB15 genome has 4,016,942 base pairs in a single circular chromosome encoding 3,767 genes.[7] The genome ... These five proteins directly control the timing of expression of over 200 genes. The five master regulatory proteins are ... of the regulatory apparatus to the proteins controlling specific cellular functions differs widely among the different species ...
specific gravity. ,. −. 1. ). ×. 1443. {\displaystyle {\text{SMV}}=\left(\left,{\frac {1}{\text{specific gravity}}}\right,-1\ ... "DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes. 15 (4): 173-183. doi:10.1093/ ... Specific gravity is measured on a scale weighing the same volume of water at 4 °C (39 °F) and sake at 15 °C (59 °F). The ... Nihonshu-do (日本酒度) is calculated from the specific gravity of the sake and indicates the sugar and alcohol content of the sake ...
CRX further defines the photoreceptor specific panel of genes being expressed. NRL expression leads to the rod fate. NR2E3 ... To be more specific, photoreceptor proteins in the cell absorb photons, triggering a change in the cell's membrane potential. ... Each transducin then activates the enzyme cGMP-specific phosphodiesterase (PDE).. *PDE then catalyzes the hydrolysis of cGMP to ... the melanopsin-containing ganglion cells discharge nerve impulses that are conducted through their axons to specific brain ...
"Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal ... General Trsp gene deletion is lethal to the embryo. The results of this research was used as a model for Kashin-Beck disease. ... General gene knock out of the TGF-β resulted in death. Conditional inactivation of TGF-βr2 of osteochondroprogenitor cells in ... Sox9 blocked osteochondroprogenitor cells were found to express osteoblast marker genes, reprogramming the cells into the ...
A patient admitted to the hospital is usually under the care of a specific team based on their main presenting problem, e.g., ... Many modern molecular tests such as flow cytometry, polymerase chain reaction (PCR), immunohistochemistry, cytogenetics, gene ... A profession is said to be regulated when access and exercise is subject to the possession of a specific professional ... Each radiopharmaceutical consists of two parts: a tracer that is specific for the function under study (e.g., neurotransmitter ...
... researchers have pinpointed sex-specific changes in gene expression. ... The authors also report that opposing gene expression changes were specific to the different brain regions. For example, if a ... Cognitive ability genes identified Unlocking the genes responsible for cognitive ability has proven challenging. Breaking ... The study identified 706 genes that were expressed differently in men with major depression and 882 genes that were expressed ...
USP3 ubiquitin specific peptidase 3 [Homo sapiens] USP3 ubiquitin specific peptidase 3 [Homo sapiens]. Gene ID:9960 ... Gene Ontology Provided by GOA Function. Evidence Code. Pubs. RNA polymerase II proximal promoter sequence-specific DNA binding ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... USP3 ubiquitin specific peptidase 3 [ Homo sapiens (human) ] Gene ID: 9960, updated on 3-May-2020 ...
USP7 ubiquitin specific peptidase 7 [Homo sapiens] USP7 ubiquitin specific peptidase 7 [Homo sapiens]. Gene ID:7874 ... Gene Ontology Provided by GOA Function. Evidence Code. Pubs. Lys48-specific deubiquitinase activity IDA Inferred from Direct ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... USP7 ubiquitin specific peptidase 7 [ Homo sapiens (human) ] Gene ID: 7874, updated on 14-Jun-2020 ...
David W. Galbraith, "Global Analysis of Cell Type-Specific Gene Expression," Comparative and Functional Genomics, vol. 4, no. 2 ... Global Analysis of Cell Type-Specific Gene Expression. David W. Galbraith University of Arizona, Department of Plant Sciences, ...
Buy Specific Gene Expression and Epigenetics by Kasirajan Ayyanathan from Waterstones today! Click and Collect from your local ... This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The ... Specific Gene Expression and Epigenetics: The Interplay Between the Genome and Its Environment (Hardback). Kasirajan Ayyanathan ...
Specific CARD15 mutations have been linked with the intestinal site... more ... Genetic studies are yielding evidence associating particular variants of the CARD15 gene with the prognosis of Crohn disease.{ ... Are specific genes prognostic factors in Crohn disease?. Updated: Jul 26, 2019 ... 10] Specific CARD15 mutations have been linked with the intestinal site of the disease (eg, ileal site), and certain variants ...
Viral gene transfer systems consisting of replication-deficient pseudo-type viruses which carry the VEGF on their envelope are ... Herein, gene transfer systems play an important role. With them, the targeted expression of certain proteins in the tumour ... Features: Specific implementation in the vascular system, high capacity for the incorporation of foreign DNA, not toxic to ... A newer strategy is the specific interference with the structure and function of the tumour endothelium in order to prevent the ...
Gene Specific Sequencing. 481436. Additional Clinical Info. 55752-0. 451910. Gene Specific Sequencing. 481437. Comments:. 8251- ... Gene Specific Sequencing. 481438. Method/Limitations:. 49549-9. 451910. Gene Specific Sequencing. 481440. Disclaimer:. 62364-5 ... Indicate the specific gene(s) to be analyzed on the test request form. Failure to indicate the gene(s) will result in testing ... Full gene sequencing for any one of the following genes: ABCC8, ACADM, A. DA, AGA, AGL, AGXT, ALDH3A2, ALDOB, ARSA, ASL, ASPA, ...
Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables ... Gene-specific regulation by general translation factors Cell. 2002 Feb 22;108(4):545-56. doi: 10.1016/s0092-8674(02)00642-6. ... Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables ... 1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes ...
Pseudogenes are nonfunctional vestiges of genes.Investigating genes that were inactivated specifically on the human lineage or ... Human Lineage‐Specific Gene Inactivation. Wendy E Grus, University of Michigan, Ann Arbor, Michigan, USA Jianzhi Zhang, ... Grus, Wendy E, and Zhang, Jianzhi(Sep 2013) Human Lineage‐Specific Gene Inactivation. In: eLS. John Wiley & Sons Ltd, ... 2011) SIGLEC12, a human‐specific segregating (pseudo)gene, encodes a signalling molecule expressed in prostate carcinomas. ...
2013) Gene-specific transcriptional mechanisms at the histone gene cluster revealed by single-cell imaging. Mol Cell 51:480-492 ... numerous gene-specific regulators remain undiscovered. To comprehensively survey the proteome directing gene expression at a ... of proteins working in concert to ensure proper cell type-specific gene regulation (3). Finding available and highly specific ... and most lack robustness in identifying functionally relevant gene-specific regulators targeted to the gene locus of interest. ...
Human Gene Patenting While researching texts written about genes the most interesting topic that came up was human gene ... Human Gene Patenting While researching texts written about genes the most interesting topic that came up was human gene ... With genes, there are dominant genes and recessive genes, suggesting that while you ... More about Human Gene Patenting : A Specific Sequence Of Dna Essay. *. The DNA of an Entrepreneur: Is There an Entrepreneur ...
An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters ... Kim, H.A., Park, J.H., Yi, N., and Lee, M., Delivery of hypoxia and glioma dual-specific suicide gene using dexamethasone ... An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters ... specific gene therapy, Mol. Pharm., 2014, vol. 11, pp. 938-950.CrossRefPubMedGoogle Scholar ...
Y. Gondo, K. Nakamura, K. Nakao et al., "Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and ... Establishment of Methylation-Specific PCR for the Mouse p53 Gene. Ryuji Okazaki,1 Akira Ootsuyama,1 Yasuhiro Yoshida,2 and ... J. G. Herman, J. R. Graff, S. Myohanen, B. D. Nelkin, and S. B. Baylin, "Methylation-specific PCR: a novel PCR assay for ... P. G. Corn, S. J. Kuerbitz, M. M. van Noesel et al., "Transcriptional silencing of the p73 gene in acute lymphoblastic leukemia ...
Public and private efforts in the new field of toxicogenomics are focused on populating databases with gene expression profiles ... The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously ... 2002). Gene expression analysis reveals chemical-specific profiles. Toxicological Sciences, 67(2), 219-231. ... Patterns of gene expression corresponding to liver tissue derived from chemically exposed rats revealed similarity in gene ...
First Treatment Approved for Breast Cancer Caused by Specific Gene Mutation By Scott Roberts FRIDAY, Jan. 12, 2018 (HealthDay ... Food and Drug Administration to treat spreading breast cancer caused by a BRCA gene mutation. ...
Specific association of the gene product of PKD2 with the TRPC1 channel. Leonidas Tsiokas, Thierry Arnould, Chenwen Zhu, Emily ... Specific association of the gene product of PKD2 with the TRPC1 channel ... Specific association of the gene product of PKD2 with the TRPC1 channel ... Specific association of the gene product of PKD2 with the TRPC1 channel ...
... PLoS Biol. 2008 Sep 16;6(9):e225. doi ... We show that a group of plant hormone-associated genes are coexpressed at the time of day when hypocotyl growth rate is maximal ... At the molecular level, such growth rhythms could be attributed to several different layers of time-specific control such as ... This expression correlates with overrepresentation of a cis-acting element (CACATG) in phytohormone gene promoters, which is ...
... therapeutic gene, while not affecting the expression of endogenous genes, in an article in Nucleic Acid Therapeutics. ... New gene therapy method provides specific, safe control of therapeutic transgenes Mary Ann Liebert, Inc./Genetic Engineering ... New gene therapy method provides specific, safe control of therapeutic transgenes. Mary Ann Liebert, Inc./Genetic Engineering ... therapeutic gene, while not affecting the expression of endogenous genes, in an article in Nucleic Acid Therapeutics, a peer- ...
The gene mutation specific normalization of p53 protein configuration was observed at a very low concentration (10 nmol/l) that ... This new information represents an important advance in the understanding of COTI-2s specific gene mutation mechanism of ... COTI-2 Found to Correct Specific p53 Gene Mutation in Human Ovarian Cancer Cells. ... stops cancer cells from replicating by correcting the effects of specific genetic errors affecting the p53 gene. COTIs ...
Tags: Anemia, Autoimmune Disease, Cell, C-section, Gene, Gene Expression, Genes, G-Protein, Hemochromatosis, Metabolism, ... Kyoto University researchers identify specific gene as key regulator in iron uptake. *Download PDF Copy ... As described recently in Cell Reports, Kyoto University researchers have now identified a specific gene -- initially known to ... We found previously that when mice lack the gene Regnase-1 they suffer from severe autoimmune diseases and anemia, explains ...
Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila Message Subject (Your Name) has forwarded a ... Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila. Shu Kondo and Ryu Ueda ... Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila. Shu Kondo and Ryu Ueda ... Highly Improved Gene Targeting by Germline-Specific Cas9 Expression in Drosophila. Shu Kondo and Ryu Ueda ...
Autoantigen-specific T cells have tissue-specific homing properties, suggesting that these cells may be ideal vehicles for the ... We tested this hypothesis by using type II collagen-specific (CII-specific) CD4+ T hybridomas or primary CD4+ T cells after ... Modifying antigen-specific T cells by retroviral transduction for local expression of immunoregulatory proteins thus offers a ... CII-specific T cells or hybridomas were transduced using retroviral vectors to constitutively express the IL-12 antagonist, IL- ...
As a model for DFNA36, we used Beethoven mice5, which harbor a point mutation in Tmc1, a gene required for hearing that encodes ... we explored gene editing strategies to disrupt dominant mutations efficiently and selectively without affecting wild-type ... we screened 14 Cas9/gRNA combinations for specific and efficient disruption of a nucleotide substitution that causes the ... Allele-specific gene editing prevents deafness in a model of dominant progressive hearing loss. *Bence György ORCID: ...
Transcription factor that regulates gene expression in intestine. May participate in vitamin A metabolism most likely by ... Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. ENSG00000175329 Expressed in 18 organ(s ... Intestine-specific homeoboxAdd BLAST. 245. Proteomic databases. PaxDb, a database of protein abundance averages across all ... Gene expression databases. Bgeei. ENSG00000175329 Expressed in 18 organ(s), highest expression level in mucosa of transverse ...
p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ... Four distinct tokens exist: Name, Synonyms, Ordered locus names and ORF names.,p>,a href=/help/gene_name target=_top ... sp,Q46455,SELB_MOOTH Selenocysteine-specific elongation factor OS=Moorella thermoacetica OX=1525 GN=selB PE=1 SV=1 ... help/gene_ontology target=_top>More...,/a>,/p>GO - Molecular functioni. *GTPase activity Source: InterPro ...
The database contains three types of data including tissue-specific gene expression profiles, combinatorial gene regulations, ... PubMed Link: TiGER: a database for tissue-specific gene expression and regulation. ... At present the database contains expression profiles for 19,526 UniGene genes, combinatorial regulations for 7,341 ...
Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is ... Zhang, F.; Cheng, D.; Wang, S.; Zhu, J. Human Specific Regulation of the Telomerase Reverse Transcriptase Gene. Genes 2016, 7, ... Zhang F, Cheng D, Wang S, Zhu J. Human Specific Regulation of the Telomerase Reverse Transcriptase Gene. Genes. 2016; 7(7):30. ... "Human Specific Regulation of the Telomerase Reverse Transcriptase Gene." Genes 7, no. 7: 30. ...
Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation. *Anrui Lu1,2. ... DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503, 371 (2013). ... Reprogrammable CRISPR/dCas9-based recruitment of DNMT1 for site-specific DNA demethylation and gene regulation. Cell Discov 5, ... Valproate induces widespread epigenetic reprogramming which involves demethylation of specific genes. Carcinogenesis 28, 560- ...
  • Mutations in this gene have been implicated in a neurodevelopmental disorder. (
  • [ 10 ] Specific CARD15 mutations have been linked with the intestinal site of the disease (eg, ileal site), and certain variants have been found to be associated with the propensity for developing strictures and with an early onset of disease. (
  • Researchers at UT Southwestern Medical Center at Dallas have discovered a gene critical to the development of the human heart and that mutations in the gene lead to congenital heart defects - the leading noninfectious cause of death in newborns. (
  • The researchers identified mutations in the gene GATA4 as a cause of human cardiac septal defects, which occur when the walls separating the heart s four chambers do not form properly. (
  • By means of positional cloning, two genes, polycystic kidney disease-1 and -2 ( PKD1 and PKD2 ) were identified as candidates for the disease, with mutations in these genes segregating with disease phenotype ( 2 - 4 ). (
  • Fig. 4: Allele-specific targeting of human DFNA36 and human dominant mutations potentially targetable with SaCas9 and SaCas9-KKH. (
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (
  • Specifically, mutations of 56 specific genes with known clinical importance should be reported even when they are incidental to the patient's current medical condition. (
  • It differs markedly between Asians and Europeans as Asian LUAD patients tend to be female, non-smokers, and have more mutations in an important gene known as EGFR4. (
  • To address these limitations, and as a proof of principle, we focused on homologous recombination-based gene correction of multiple mutations on lamin A (LMNA), which are associated with various degenerative diseases. (
  • Prematurely declaring mutations in certain genes to be autism-specific is problematic for several reasons. (
  • Dominantly inherited disorders are not typically considered therapeutic candidates for gene augmentation (GA). We tested whether GA or genome editing (GE) could serve as a solo therapy for autosomal dominant Best disease (adBD), a macular dystrophy linked to over 100 mutations in the BEST1 gene, which encodes a homo-pentameric calcium-activated chloride channel (CaCC) in the retinal pigment epithelium (RPE). (
  • The company's approach is designed to select and confirm tumor-exclusive mutations to empower a patient's immune system to target their specific cancer. (
  • From that group, a proprietary selection platform is used to identify the ideal T cell receptors for specific mutations. (
  • To search for genes that affect collective behavior, we focused on genetic mutations that are associated with psychiatric diseases that have a social behavior component, including autism and schizophrenia. (
  • The team observed that in fish with specific genetic mutations associated with human psychiatric disease, group behavior was altered. (
  • But this new data threw a wrench in the 2002 paper's timeline, and it turns out that the FOXP2 mutations we thought to be human specific, aren't. (
  • As the underlying pathogenic events in these disorders are dominant gene mutations, simply reducing mutant allele expression may be therapeutic. (
  • Loss-of-function contributions to dominant disease can be predicted from knockout mouse models and by examining genetic case studies, in which different mutations in the same gene give rise to dominant and recessive myopathies. (
  • About 5 percent of the patients with idiopathic short stature and 80 percent of the patients with Lri-Weill syndrome had mutations in the segment either including or around the SHOX gene. (
  • Some patients had an intact SHOX gene but an unexpectedly high number of mutations in its enhancer sequences: for 26 percent of patients with SHOX deficiency and idiopathic short stature and for 45 percent of patients with SHOX deficiency and Lri-Weill syndrome, the disease could be attributed solely to a genetic mutation of the enhancer sequence. (
  • In these genes in particular, mutations in the regulatory sequences can be the decisive factor for illness. (
  • The researchers hope that their results will give them a better understanding of the causes of the disease and allow them to optimize the diagnostic possibilities for patients with SHOX gene mutations. (
  • Even if it is not possible to treat the cause, patients with mutations of the SHOX gene can benefit from a treatment of the symptoms with growth hormones," explains Professor Rappold. (
  • Using plants from 93 different Arabidopsis thaliana populations, a team led by the Gregor Mendel Institute of Plant Biology in Austria was able to find genetic associations among multiple phenotypes, or traits, suggesting that the same genes or closely related genes controlled those traits. (
  • This may show that multiple phenotypes are being controlled by a specific region of the genome,' Salt said. (
  • PHENOTYPES of mutant animals have provided deeper insight into gene function than any other means. (
  • As normal copies of disease genes likely encode essential proteins, normal allele haploinsuffi-ciency may contribute to myopathic phenotypes as well. (
  • Results demonstrate that we can also induce mutant phenotypes using conditional ectopic gene expression. (
  • One of these mutant phenotypes could not have been identified using noninducible ectopic gene expression approaches. (
  • To begin to identify specific genes that mediate heritability of insulin-related phenotypes, we selected a candidate gene, AMP deaminase 1 ( AMPD1 ), which has been shown to influence skeletal muscle adenine nucleotide levels ( 7 ) and which in turn could have effects on other enzymes, such as AMP-activated protein kinase (AMPK), that are known to influence insulin action ( 8 ). (
  • The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. (
  • Protein synthesis is the ultimate step of gene expression and a key control point for regulation. (
  • Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production. (
  • 1998) The flavin‐containing monooxygenase 2 gene (FMO2) of humans, but not of other primates, encodes a truncated, nonfunctional protein. (
  • To fully understand the molecular mechanisms governing multiple steps in gene expression, including transcription and posttranscriptional regulation for a given gene, one must first identify the various protein factors involved in the process. (
  • The gene may be responsible for the defects through its interaction with TBX5, a protein that causes a subset of syndromic cardiac septal defects. (
  • At the molecular level, such growth rhythms could be attributed to several different layers of time-specific control such as phasing of transcription, signaling, or protein abundance. (
  • Our experiments showed that COTI-2, at a low dose, restored the normal protein configuration of the R175H p53 gene mutation and did not affect normal p53 protein," said Dr. Wayne Danter, COTI's President and CEO. (
  • The gene mutation specific normalization of p53 protein configuration was observed at a very low concentration (10 nmol/l) that is easily achievable when COTI-2 is given orally. (
  • Iron 'regulation' occurs at multiple levels, from controlling gene expression to degrees of protein synthesis, but some key factors have yet to be uncovered. (
  • Our results showed that Regnase-1 degrades the mRNA of TfR1, thereby inhibiting the synthesis of the TfR1 protein, and additionally that it likely regulates other important iron-controlling genes. (
  • The system comprises two transgenic strains: one expressing Cas9 protein from the germline-specific nanos promoter and the other ubiquitously expressing a custom guide RNA (gRNA) that targets a unique site in the genome. (
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (
  • However, both the design and the protein engineering of the ZFs (or TALEs) that are required for the binding of specific loci are time-consuming and costly, and their applications are therefore limited. (
  • The exome is the DNA sequence of genes that are translated into protein. (
  • We showed that genes related to presynaptic secretory function, and the gene encoding the regulator of G-protein signaling 4 (RGS4), were consistently decreased in subjects with schizophrenia. (
  • Among the factors identified by the YOH screen was Gtf2ird1 (general transcription factor II-I repeat domain-containing protein 1), a helix-loop-helix (HLH) containing transcription factor that had not been previously implicated in retinal gene expression. (
  • These knockout mice demonstrated a reduction in end-diastolic and end-systolic volume by echocardiography, activation of the fetal gene program (ie, increased atrial natriuretic peptide and alpha skeletal actin gene expression), and increased expression of modulatory calcineurin inhibitory protein 1 (MCIP1), a direct downstream target of calcineurin/nuclear factor of activated T cell signaling. (
  • Treatment of neonatal cardiomyocytes with 1,25-dihydroxyvitamin D partially reduced isoproterenol-induced MCIP1 mRNA and protein levels and MCIP1 gene promoter activity. (
  • Integrating genetic variation with cell-type specific variation in transcript and protein abundance to make causal inferences about potential molecular targets. (
  • CREB1 is a gene that encodes a regulatory protein called CREB that orchestrates the expression of large numbers of other genes that play important roles in the brain and the rest of the body as well. (
  • Gastrin was found to control the expression of 120 which could be divided into two major groups depending on the known or anticipated biological function of the encoded protein: genes encoding proteins involved in the secretory process and genes encoding proteins needed to generate energy for secretion. (
  • Distinct prestalk and ALC subtypes have been identified using ecmA , a gene that encodes an extracellular matrix protein. (
  • We identify a novel bZIP protein that interacts with the ecmA promoter and show that it is a DIF-1 responsive regulator of prestalk specific gene expression. (
  • By using these reagents and v-abl-specific antisera, it was demonstrated that the P210 in CML cells is indeed the protein product of the 8.5-kilobase transcript. (
  • The molecular cloning of the gene (SSG1) encoding a sporulation-specific exo-1,3-beta-glucanase was achieved by screening a genomic library with a DNA probe obtained by polymerase chain reaction amplification using synthetic oligonucleotides designed according to the nucleotide sequence predicted from the amino-terminal region of the purified protein. (
  • Insulin clearance is a highly heritable trait, and specific haplotypes within the AMPD1 gene, which encodes a skeletal muscle−specific protein, are associated with variation in insulin clearance. (
  • An artificial double tandem tumor-specific promoter based on survivin and human telomerase reverse transcriptase gene promoters was constructed. (
  • Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas-implications for tumor biology and potential clinical utility," Oncogene , vol. 20, no. 36, pp. 5033-5042, 2001. (
  • c Illustration of the five sgRNAs designed for targeting the promoter region of the human RANKL gene. (
  • To this end, we generated a resource for inducible cell type-specific transactivation in Arabidopsis ( Arabidopsis thaliana ) based on the well-established combination of the chimeric GR-LhG4 transcription factor and the synthetic pOp promoter. (
  • When we combined these transgenic lines with effectors under the control of the pOp promoter, we observed tight temporal and spatial control of gene expression. (
  • In silico analysis of the CS genes revealed an over-representation of dehydration-responsive element/C-repeat binding factor (DREB1A/CBF3) binding sites and EveningElement motifs in their promoter regions. (
  • The CS-ERF are closely related to the CBF transcription factors and could potentially bind the DREB1A/CBF3 promoter elements in the CS genes. (
  • In addition, integrative analyses using RNA-seq and MBD-seq revealed that Uhrf1 deficiency decreased genome-wide DNA methylation and increased gene expression through reduced DNA methylation in the promoter regions of 28 genes, including Hspb1, which is reported to be an IL-1-related gene and to affect chondrocyte differentiation. (
  • We speculated that epigenetic mechanisms, e.g., gene promoter hypermethylation, might account for TNS3 downregulation. (
  • In this study, we identified and validated a TNS3 gene promoter containing a CpG island, and quantified the methylation level within this region in RCC. (
  • Pyrosequencing enabled quantitative determination of DNA methylation of each CpG dinucleotide (a total of 43) in the TNS3 gene promoter. (
  • Tissue and cell-specific transcriptional activity of the human cytomegalovirus immediate early gene promoter (UL123) in zebrafish. (
  • The proximal promoter region of this gene behaves as a strong enhancer and was commonly used to overexpress genes in vitro and in vivo in numerous cell types and species. (
  • However, there was no detailed report on the spatial and temporal transcriptional activity of the human CMV-IE gene promoter in zebrafish. (
  • In the present study, we generated stable transgenic zebrafish lines carrying the eGFP reporter gene under the control of the human CMV-IE gene promoter (-602/-14). (
  • In adult, the global expression pattern was similar but not identical to that described for the simian CMV-IE gene promoter in stable zebrafish with high transgene expression in the spinal cord, olfactory organs, central nervous system, neuromasts, retina, and skeletal muscles. (
  • Interestingly, our study shows that the tissue and cell specific expression pattern of the human CMV-IE gene promoter is rather well conserved in stable transgenic zebrafish compared to that observed in mouse. (
  • 1 Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. (
  • Eukaryotic gene regulation is a complex process, often coordinated by the action of tens to hundreds of proteins. (
  • Although previous biochemical studies have identified many components of the basal machinery and various ancillary factors involved in gene regulation, numerous gene-specific regulators remain undiscovered. (
  • They compare the results of studies to regulate the expression of a transgene by targeting either the guide or passenger strand of miR-122, and discuss the underlying mechanisms to explain the observed miRNA activity and up- and down-regulation of gene expression. (
  • A database of tissue-specific gene regulation in human tissues. (
  • Although there is a high conservation between human and mouse TERT genes, the regulation of their transcription is significantly different in these two species. (
  • Reductions in expression were identified for genes involved in the regulation of ornithine and polyamine metabolism, the mitochondrial malate shuttle system, the transcarboxylic acid cycle, aspartate and alanine metabolism, and ubiquitin metabolism. (
  • Spatial regulation of specific gene expression through photoactivation of RNAi. (
  • These findings represent a mechanistic paradigm of gene-specific regulation of translation in response to a key growth regulator. (
  • Our study has shown that the CYP19A1 gene may be involved in the genetic regulation of BP in women. (
  • The goal of this initiative is to encourage research that will advance our understanding of brain cell type-specific gene regulation to elucidate the pathogenesis of mental disorders. (
  • To determine proteins possibly involved in regulation of these genes, we performed bioinformatics analysis and found enriched motifs of for MafB and Zfp410 binding sites. (
  • In conclusion, both USF1 and USF2 are essential for AGT transcriptional regulation, and distinct sex-specific and tissue-specific mechanisms are involved in the activities of these transcription factors in vivo. (
  • Not only the gene itself, its abnormal regulation can also trigger sho. (
  • These results indicate that Uhrf1 governs cell-type specific transcriptional regulation by controlling the genome-wide DNA methylation status and regulating consequent cell differentiation and skeletal maturation. (
  • Developmental progression and differentiation of distinct cell types depend on the regulation of gene expression in space and time. (
  • Of these, we propose RNF115, at locus 1q21.1, as a strong novel target gene associated with BC risk, and reinforce the role of miRNA-mediated cis-regulation at locus 19p13.11. (
  • We believe that integrating allele-specific querying in miRNA-binding prediction, and data supporting cis-regulation of expression, improves the identification of candidate target genes in BC risk, as well as in other common cancers and complex diseases. (
  • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. (
  • Recent genome‐wide surveys showed that human‐specific pseudogenisation events occurred much more frequently to chemosensory and immune response genes than to other genes. (
  • Genome-wide association mapping compares the sequence of DNA in genomes of many individual plants or animals to find similarities that narrow the scope of the search for a particular gene. (
  • Our method is readily scalable to high-throughput gene targeting, thereby accelerating comprehensive functional annotation of the Drosophila genome. (
  • Even today, however, loss-of-function mutants in the vast majority of genes are yet to be described, calling for a breakthrough technology that allows systematic gene targeting to complete our understanding of the Drosophila genome. (
  • We found striking differences at specific sites in the genome between plants from locations with and without heavy metals,' said Rellstab. (
  • Yet the systematic exploration of quantitative changes in translation at a genome-wide scale in response to specific stimuli has only recently become technically feasible. (
  • These latest results build on research published by Dr. Zubenko and his team in October of 2002 that identified a small region of chromosome 2 equal to 0.01 percent of the human genome as the potential hiding place for a susceptibility gene for depression in women. (
  • Large-scale technologies, such as methylation microarray assays and specific sequencing of methylated DNA, have been used to determine whole genome profiles of CpG island methylation in tissue samples. (
  • The large number of hypothetical genes in the CFT073 genome, especially those shown to be UPEC specific, strongly suggests that many urovirulence factors remain uncharacterized. (
  • The complement of genes found in the genome is a balance between gene gain and gene loss. (
  • these models allow us to estimate the relative genome-wide rates of gene birth, death, innovation and extinction (loss of an entire family) for the first time. (
  • These results suggest that an important mechanism in the evolution of genome content is the presence of lineage-specific gene family changes. (
  • It is now known that homeopathic remedies interact with the genetic blueprint (genome) and increase the expression of many genes. (
  • Because the human genome contains genes that promote health as well as genes that cause disease when their expression is increased, it became important to be able to control the specificity of homeopathic remedy/genomic interactions. (
  • From a health care standpoint, this is a very important observation since, as indicated above, the human genome (the genetic blueprint) contains many genes that cause disease as well as genes that promote health and protect against disease. (
  • Conditional transactivation of reporter genes was achieved in a predictable, tissue-specific pattern of expression, following the insertion of the activator or the responder T-DNA in a wide variety of positions in the genome. (
  • Most breast cancer (BC) risk-associated single-nucleotide polymorphisms (raSNPs) identified in genome-wide association studies (GWAS) are believed to cis-regulate the expression of genes. (
  • To test this, we adapted two miRNA-binding prediction algorithms-TargetScan and miRanda-to perform allele-specific queries, and integrated differential allelic expression (DAE) and expression quantitative trait loci (eQTL) data, to query 150 genome-wide significant (P≤5×10−8) raSNPs, plus proxies. (
  • As a result, the gene drive insertion in the genome will re-occur in each organism that inherits one copy of the modification and one copy of the wild-type gene. (
  • This initiative encourages research to develop new, or adapt existing, computational and statistical approaches to aggregate, mine, and conduct integrative analyses of single-cell and bulk tissue multi-omic datasets from brain samples (e.g., gene expression, chromatin state, histone modifications, DNA methylation, etc.) to achieve new insights into the biology of psychiatric disorders. (
  • Given folate's role in regulating nucleotide synthesis and DNA and histone methylation, these changes are often linked to altered gene expression and might be controlled by specific regulatory networks. (
  • Gene methylation and expression often have an inverse relationship with decreased methylation resulting in increased expression ( 6 , 7 ). (
  • In addition to changes in gene expression, abnormal DNA-methylation is known to play an important role in cancer onset and development, and colon cancer is no exception to this rule. (
  • In this article, publicly available microarray-based gene expression and methylation data sets are used to characterize expression subtypes with respect to locus-specific methylation. (
  • Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) α-negative breast tumors displays aberrant methylation at one site within the ER gene CpG island. (
  • To examine more sites and increase sensitivity, we developed a methylation-specific PCR assay to map methylation of the entire ER CpG island. (
  • Furthermore, CpG-specific higher methylation levels were correlated with lower TNS3 gene expression levels in RCC samples. (
  • Vertebrate TRP genes ( TRPC1-7 ) are mammalian homologues of the Drosophila trp and trp -like ( trpl ) and are believed to encode putative six membrane-spanning Ca 2+ channels activated by depletion of Ca 2+ stores ( 10 - 13 ). (
  • The iroBCDEN genes encode the salmochelin siderophore system present in Salmonella enterica and some ExPEC strains. (
  • Cordts S, Bantin J, Wittich PE, Kranz E, Lörz H, Dresselhaus T (2001) ZmES genes encode peptides with structural homology to defensins and are specifically expressed in the female gametophyte of maize. (
  • On the other hand, an individual's health status can be changed by re-arranging the expression of genes that encode the proteins that promote or resolve a particular set of disease symptoms. (
  • At the molecular level, an endonuclease gene drive works by cutting a chromosome at a specific site that does not encode the drive, inducing the cell to repair the damage by copying the drive sequence onto the damaged chromosome. (
  • additional sequences can be introduced in the gene drive to encode new functions. (
  • The authors also report that opposing gene expression changes were specific to the different brain regions. (
  • Dr. Seney and colleagues note that because their study looked at postmortem brain tissue, they were unable to assess whether the opposing gene expression changes they identified led to differences in how major depression affects men and women. (
  • As a model for DFNA36, we used Beethoven mice 5 , which harbor a point mutation in Tmc1 , a gene required for hearing that encodes a pore-forming subunit of mechanosensory transduction channels in inner-ear hair cells 6 . (
  • In this work we develop electrostatically adsorbed poly(glutamic acid)-based peptide coatings to alter the exterior composition of a core gene delivery particle and thereby affect tissue-specificity of gene delivery function in vivo. (
  • Thus, variations in nanoparticle peptide coating density can alter the tissue-specificity of gene delivery in vivo. (
  • We used in situ hybridization to determine expression specificity for seven genes: one transcript was expressed both in the egg cell and in the central cell, one was expressed in the egg cell and synergids, two were expressed in the central cell, two were expressed in the synergids, and one was expressed in the central cell and the synergids. (
  • However, the current evidence does not establish meaningful specificity of any genes for autism. (
  • Two recent studies examined the relative specificity of autism-linked genes by comparing which of the genes are mutated - and how often - in two different groups of people: those who participated in autism studies and those who participated in studies of intellectual disability (although some people in each group had both conditions). (
  • It would also be premature to limit autism neurobiology research studies to a subset of genes and circuits based on data from the cohorts of convenience that have been used to determine relative specificity of the genes for autism. (
  • This article describes the evolution, applications and advantages of these SSHD remedies and why it is important to understand more about the gene targeting specificity of homeopathic remedies. (
  • The chimeric transcription factor XVE, in conjunction with Gateway recombination cloning technology, was used to generate a tractable system that can efficiently and faithfully activate target genes in a variety of cell types. (
  • mRNA (messenger RNA) pair binding stability in five candidate target genes. (
  • The application of gene expression profiling technology to examine multiple genes and signaling pathways simultaneously promises a significant advance in understanding toxic mechanisms to ultimately aid in protection of public health. (
  • To determine whether abnormal expression of genes encoding proteins involved in cellular metabolism contributes to this dysfunction, we used cDNA microarrays to perform gene expression profiling of all major metabolic pathways in postmortem samples of PFC area 9 from 10 subjects with schizophrenia and 10 matched control subjects. (
  • Genes comprising 71 metabolic pathways were assessed in each pair, and only five pathways showed consistent changes (decreases) in subjects with schizophrenia. (
  • The present report demonstrates that only five of the metabolic pathways examined showed consistent changes (decreases) in subjects with schizophrenia and that four of these groups are linked together by the presence of overlapping gene members. (
  • The identification of CREB1 leads Dr. Zubenko's team to believe that genes for other components of cell signaling pathways that operate through CREB may be involved in mood disorders. (
  • Conversely, individual genes, pathways, and metabolites can have diverse or even opposing roles depending on the tissue context. (
  • we have identified a novel T-ALL risk gene USP7, and our results suggest that loss-of-function variants at this locus (either somatic or germline) promote T-Cell Acute Lymphoblastic Leukemia leukemogenesis. (
  • Genetic studies are yielding evidence associating particular variants of the CARD15 gene with the prognosis of Crohn disease. (
  • Although most gene‐disrupting variants are under negative selective pressure, some population genetic studies of segregating pseudogene loci reveal signatures of positive selection for the disrupted allele, suggesting that gene loss can be beneficial. (
  • At least one gene in each exome method was missing more than 40 percent of disease-causing genetic variants, and we found that the worst-performing method missed more than 90 percent of such variants in four of the 56 genes," he says. (
  • A total of 17,774 disease-causing genetic variants are annotated in the Human Gene Mutation Database (HGMD) for the 56 genes mentioned in the ACMG recommendations. (
  • 13-16 Furthermore, it has been reported that the effect of these genetic variants of CYP19A1 gene are dependent of body fat accumulation in women. (
  • Studies of these variants have implicated more than 100 genes - and counting - in autism. (
  • And as we learn more about these genes and the consequences of variants that disrupt their function, we have the potential to better understand the mechanisms underlying cases of autism in which a definitive genetic diagnosis cannot yet be made. (
  • deleterious variants in the same genes are also implicated in other neurodevelopmental conditions, such as intellectual disability, epilepsy, attention deficit hyperactivity disorder and schizophrenia. (
  • Specific genes and variants do not map neatly onto categorical clinical diagnoses or the core cognitive and behavioral traits that define them. (
  • They found that these traits were associated with common genetic variants in seven gene regions. (
  • We hypothesise that cis-regulatory variants contributing to disease risk may be affecting microRNA (miRNA) genes and/or miRNA binding. (
  • Interestingly, although most of the metabolic genes that were consistently decreased across subjects with schizophrenia were not similarly decreased in haloperidol-treated monkeys, the transcript encoding the cytosolic form of malate dehydrogenase displayed prominent drug-associated increases in expression compared with untreated animals. (
  • In the present study, we wished to determine whether transcript levels in more than 70 different gene groups involved in cellular metabolism, which could impact the quality of neuronal communication, were altered in a larger sample of subjects with schizophrenia and whether the effects on these gene groups were interrelated. (
  • CML cells have two novel products: an 8.5-kilobase RNA transcript containing both abl and bcr and a 210-kilodalton phosphoprotein (P210) recognized by v-abl-specific antisera. (
  • Northern (RNA) analysis reveals a unique SSG1-specific transcript, 1.7 kb long, which can be detected only in sporulating diploids (MATa/MAT alpha) but does not appear in vegetatively growing cells or in nonsporulating diploids (MAT alpha/MAT alpha) when incubated under nitrogen starvation conditions. (
  • Transcript levels of CS genes peak at 2 to 3 days postinoculation, when pathogen growth is highest, and decline at later stages of infection. (
  • Using a ceruloplasmin cDNA clone in RNA blot analysis, a single 3.7 kb ceruloplasmin-specific transcript was detected in rat mammary gland tissue from pregnant and lactating animals. (
  • Furthermore, in the human adipose tissue, ob gene expression occurred in mature adipocytes rather than in stromal-vascular cells. (
  • These data suggested a potential regulatory role for the genes in adipose tissue development. (
  • When they used a molecular technique to silence the activity of either of these genes in the cells, they observed impaired fat cell formation in SAT, whereas only Ube2e2 disruption impaired adipose tissue development in VAT. (
  • f Assessment of the transcriptional level of RANKL gene by quantitative RT-PCR assay. (
  • EAE protection was accompanied by sex- and genotype-specific suppression of proinflammatory transcriptional programs in CD4 T effector cells, but not CD4 regulatory T cells. (
  • These numbers may be in order and fit perfectly into your puzzle, but then there is that one out of place piece that makes the puzzle not complete, that essentially is what the BRCA 1 gene mutation is, just a misplaced puzzle piece. (
  • The BRCA 1 gene mutation can go by many names like breast cancer 1, early onset or IRIS, but no matter what name you call it, it still inflicts some questions and concerns. (
  • FRIDAY, Jan. 12, 2018 (HealthDay News) -- Lynparza (olaparib) has been approved by the U.S. Food and Drug Administration to treat spreading breast cancer caused by a BRCA gene mutation. (
  • This new information represents an important advance in the understanding of COTI-2's specific gene mutation mechanism of action with the results extending the test outcomes generated by Dr. Yu et al from the University of New Jersey as published in the May 2012 edition of the journal, Cancer Cell. (
  • A human ovarian cancer cell line (TOV-112D) that expresses the specific p53 mutation, R175H, was treated with a low concentration of COTI-2. (
  • Zhang said this shows how a mutation in this gene disrupts growth and differentiation of so-called neural progenitor cells, which go on to become different brain cell types. (
  • The study revealed that the tumour mutation landscape in Asian patients is very unique, and several new genes may be implicated in the development of lung cancers in Asians. (
  • The obese ( ob ) gene, the mutation of which results in severe hereditary obesity and diabetes in mice, has recently been isolated through positional cloning. (
  • Defining these cancer mutation targets for each person, known as neoantigens, enables the company to use its proprietary gene engineering technologies to manufacture an immune cell therapy product for each person with cancer. (
  • Once the target is authenticated, the company uses non-viral gene editing to engineer the ideal mutation-targeted T cell receptors into T cells from the same patient. (
  • SHOX gene mutation is frequently the cause of short stature /p. (
  • In many cases, the mutation of one regulatory sequence of the SHOX gene is sufficient to give rise to the full-blown syndrome. (
  • Professor Rappold's team discovered back in 2007 that in over 4 percent of children with idiopathic short stature, the trigger for the disorder was a mutation in the SHOX gene. (
  • When there is a mutation of the SHOX gene, patients reach a height up to 20 cm less than expected. (
  • The astounding thing is that this enhancer mutation is quite far away from the affected gene and yet it still leads to the exact same clinical symptoms as a mutation in the gene itself," says Professor Rappold. (
  • Analysis of expression of key known VitD metabolism genes between B6 and PWD mice revealed that their expression is genetically determined and sex specific and implicated Cyp27b1 and Vdr as candidate genes responsible for differential EAE responses to VitD modulation. (
  • Differential expression by race was observed for 48% of genes measured, although the magnitudes of expression differences were small. (
  • The researchers report that a control system based on targeting the passenger strand of miR-122 rather than the guide strand can regulate expression of an exogenous, therapeutic gene, while not affecting the expression of endogenous genes, in an article in Nucleic Acid Therapeutics , a peer-reviewed journal from Mary Ann Liebert, Inc. publishers . (
  • GXD's primary emphasis is on endogenous gene expression during development. (
  • The decrease in endogenous AGT expression was insufficient to alter systolic blood pressure at baseline but caused reduced systolic blood pressure in female USF1 gene trap mice fed a high-fat diet. (
  • Advances in inducible gene expression technologies will facilitate more precise functional analyses of endogenous and exogenous genes, revealing new roles for genes that act at multiple stages in the plant life cycle. (
  • Nucleotide diversity in the CASP12 gene in noncoding regions of the pseudogenised allele and functional allele. (
  • Red circles and green dots show the percent nucleotide diversity in the pseudogenized and functional alleles, respectively, at each of nine noncoding regions within and around the gene (black bars). (
  • In this study, specific differences in DNA, called single nucleotide polymorphisms, or SNPs, were compared at 250,000 sites across the genomes of many individuals. (
  • To circumvent these limitations, we screened 14 Cas9/gRNA combinations for specific and efficient disruption of a nucleotide substitution that causes the dominant progressive hearing loss, DFNA36. (
  • Almost fifty years ago, it was discovered that, in a clinical setting, gene specific targeting could be brought about by the use of homeopathic DNA molecules with defined nucleotide sequences. (
  • He demonstrated that DNA molecules with defined nucleotide sequences, could be used to target and modulate the activity of various health promoting genes. (
  • Roles of the iro genes for virulence in chickens and production of salmochelins were assessed by introducing plasmids carrying different combinations of iro genes into an attenuated salmochelin- and aerobactin-negative mutant of O78 strain chi7122. (
  • Through a combined approach of a large-scale human genetics study coupled with experiments in a mouse model, this research provides new insight into the genetics of body fat distribution and supports physiological roles for specific genes in fat cell development. (
  • The principal hypothesis underlying a toxicogenomic or pharmacogenomic strategy is that chemical-specific patterns of altered gene expression will be revealed using high-density microarray analysis of tissues from exposed organisms. (
  • This expression correlates with overrepresentation of a cis-acting element (CACATG) in phytohormone gene promoters, which is sufficient to confer the predicted diurnal and circadian expression patterns in vivo. (
  • To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. (
  • As a resource for gene discovery and to help identify genes exhibiting cell-specific expression patterns, we constructed cDNA libraries from female gametophytes and from egg cells of maize and sequenced more than 8,500 ESTs. (
  • Beyond tracking swimming patterns, Fishman plans to dive deeper into zebrafish biology, looking at how neuronal activity and gene expression might connect to the behavioral changes. (
  • This is an important consideration because, in the last few decades, scientific studies have dramatically increased our understanding of genes that promote symptom patterns of many forms of ill-health when their expression is restricted as well as genes that promote symptoms of ill-health or disease when their expression is increased. (
  • Finally, although some studies have explored differences in gene expression patterns across race, the clinical implications of such differences remain unclear ( 6-8 ). (
  • In this latest study, lead author Dr. Marianne Seney, Ph.D., from the Department of Psychiatry at the University of Pittsburgh Medical School in Pennsylvania, and colleagues pinpointed specific genetic differences between men and women with major depression. (
  • Investigating genes that were inactivated specifically on the human lineage or within humans can reveal the genetic basis of interspecies differences between humans and chimpanzees and interindividual differences within humans. (
  • Large‐scale human genetic variation databases reveal hundreds of segregating pseudogenes, suggesting individual and population differences in functional gene content. (
  • We wanted to know what genes captured by that chromosome also differ between the morphs, in order to identify the genetic mechanisms that may explain the behavioural differences," Horton says. (
  • The field observations were followed by laboratory analyses of the study subjects, to home in on differences in their neuroendocrine gene expression. (
  • While sequencing results suggested that Eap sequences are highly conserved, size differences of various eap genes as a result of different numbers of repeats have been described (Fig. 1 ) ( 19 ). (
  • We explored differences in gene expression between EAM and AAM for three commercially available panels recommended by the National Comprehensive Cancer Network for prostate cancer prognosis. (
  • Because of observed racial differences across three commercial gene expression panels for prostate cancer prognosis, caution is warranted when applying these panels in clinical decision-making in AAM. (
  • Differences in gene expression by race for three commercial panels for prostate cancer prognosis indicate that further study of their effectiveness in AAM with long-term follow-up is warranted. (
  • While differences in access to care and socioeconomic status are contributing factors to prostate cancer disparities, accumulating evidence suggests the molecular genetic drivers implicated in carcinogenesis and prostate cancer progression exert their effects in a race-specific manner ( 2 ). (
  • Gene replacement of the p53 gene with the lacZ gene in mouse embryonic stem cells and mice by using two steps of homologous recombination," Biochemical and Biophysical Research Communications , vol. 202, no. 2, pp. 830-837, 1994. (
  • We found previously that when mice lack the gene Regnase-1 they suffer from severe autoimmune diseases and anemia,' explains first author Masanori Yoshinaga. (
  • Using those two models, Zhang and his colleagues deleted the RAB39B gene in both the mice and the human brain organoid. (
  • The mice showed signs of macrocephaly and autism-like behaviors, and the human brain organoids were enlarged and impaired with the removal of the gene. (
  • Mice homozygous for disruptions in this gene have poorly developed photoreceptors that degenerate with age. (
  • By training mice to eat at a time when they normally wouldn't, the researchers found that food turns on body-clock genes in a particular area of the brain. (
  • The scientists set the mice on a regular feeding schedule, then examined their brain tissue to find where Per genes were turned on in sync with feeding times. (
  • When the mice subsequently went two days without food, the genes continued to turn on in sync with the expected feeding time. (
  • Finally, the sexually dimorphic responses to dural CGRP were not specific to rats as similar female-specific hypersensitivity responses were seen in mice, where increased grimace responses were also observed. (
  • Alfieri JA, Martin AD, Takeda J, Kondoh G, Myles DG, Primakoff P (2003) Infertility in female mice with an oocyte-specific knockout of GPI-anchored proteins. (
  • To study the contribution of USF1 on AGT gene expression, mice carrying a (−20C) human AGT (hAGT) transgene were bred with mice harboring a USF1 gene trap allele designed to knock down USF1 expression. (
  • They measured activity of four analogous mouse genes in different fat depots in male mice and found variable activity for two genes: the Ube2e2 gene was more highly activated in VAT than in SAT or PAT during fat cell development. (
  • The Atxn1 gene was more active in the SAT of mice with diet-induced obesity than in lean mice. (
  • 1999). Dominant NM patients have one mutant and one normal TPM3 gene copy, while human carriers of recessive alleles and TPM3+/- mice are normal, and TPM3-/- animals die as embryos (Lehtokari et al. (
  • Here we show that limb mesenchymal cell-specific Uhrf1 conditional knockout mice ( Uhrf1 Δ Limb/ Δ Limb ) exhibit remarkably shortened long bones that have morphological deformities due to dysregulated chondrocyte differentiation and proliferation. (
  • Sung Jin Kim, Chang Ho Lee, and Seong-Wook Lee, Dankook University, Yongin, Republic of Korea, describe the novel gene therapy control system they developed in the article "Targeting the MicroRNA Passenger Strand for Regulating Therapeutic Transgenes" . (
  • We demonstrate rapid generation of mutants in seven neuropeptide and two microRNA genes in which no mutants have been described. (
  • The DNA of an Entrepreneur Is there an Entrepreneur Gene or an Entrepreneur Chromosome within the DNA of an Entrepreneur? (
  • RAB39b was reported as an autism spectrum disorder (ASD) risk gene, linked to the X chromosome, Zhang said. (
  • The researchers focused on ER-alpha as a primary candidate, since it is one of the genes captured by the chromosome inversion and had been previously linked to social behaviours in vertebrates. (
  • Researchers in Heidelberg have now discovered that sequences of genetic material on the X and Y chromosome that regulate this gene are also crucial for growth in children. (
  • This gene lies on the X chromosome and is responsible for growth in the epiphyseal plate, where the long bones of the arms and legs grow in length. (
  • Patenting Genes of Organism The advancement of technology has lead to many scientists conducting more experiments with gene modification. (
  • This has lead to scientists to isolate certain genes that may cause a certain disease, thus modified genes may change the organism in a particular way. (
  • Dawkins uses the term "selfish gene" as a way of expressing the gene-centred view of evolution (as opposed to the views focused on the organism and the group), popularising ideas developed during the 1960s by W. D. Hamilton and others. (
  • Gene patenting is the exclusive right to a specific sequence of DNA given by a government to the individual , organization or corporation who claims to have first identified the gene. (
  • you can download the DNA sequence of your interested gene with ensemble menu directly and design the extrone-spaned primer for real-time pcr. (
  • Methods and Results- Targeted deletion of the exon 4 coding sequence in the VDR gene resulted in an increase in myocyte size and left ventricular weight/body weight versus controls both at baseline and following a 7-day infusion of isoproterenol. (
  • 1,25(OH) 2 D functions as a ligand for the nuclear vitamin D receptor (VDR) which, when paired with its heterodimeric retinoid X receptor partner, binds to sequence-specific recognition elements on DNA and stimulates or represses transcription of contiguous genes. (
  • Based on this advanced homeopathic DNA gene targeting system, a series of sequence specific homeopathic DNA (SSHD) remedies has now been developed. (
  • To achieve the self-propagating nature of gene drives, this repair template contains at least the endonuclease sequence. (
  • David E. Salt, a Purdue professor of plant biology and co-author of a Nature paper on the study released Wednesday (March 24), said the ability to find these types of genetic links could speed scientists' ability to find and isolate genes and understand their function. (
  • The induction of several CS genes was found to be isolate specific. (
  • At present the database contains expression profiles for 19,526 UniGene genes, combinatorial regulations for 7,341 transcription factor pairs and 6,232 putative CRMs for 2,130 RefSeq genes. (
  • A range of putative and established virulence genes have been identified in UPEC that enable these isolates to overcome host defenses and establish infection in this unique niche. (
  • Interestingly, of the few genes expression changes that were shared between men and women, the researchers identified just 21 genes that were altered in the same direction. (
  • Interestingly, gastrin stimulation also increased ECL cells expression of anti-apoptotic genes. (
  • Interestingly, Saha and colleagues[3] discovered that individual remedies such as Condurango and Hydrastis canadensis have the capacity to re-arrange the expression of many genes, well over a hundred. (
  • To comprehensively survey the proteome directing gene expression at a specific genomic locus of interest, we developed an in vitro nuclease-deficient Cas9 (dCas9)-targeted chromatin-based purification strategy, called "CLASP" (Cas9 locus-associated proteome), to identify and functionally test associated gene-regulatory factors. (
  • The database contains three types of data including tissue-specific gene expression profiles, combinatorial gene regulations, and cis-regulatory module (CRM) detections. (
  • Results: We developed a method to infer regulatory interactions based on a model where transcription factors (TFs) and their targets are both differentially expressed in a gene-specific, critical sample contrast, as measured by repeated two-way t-tests. (
  • Regulatory sequences ensure that the respective gene is copied more or less frequently and thus is more or less effective. (
  • The iroE gene was not required for virulence, since introduction of iroBCDN restored the capacity to cause lesions and colonize extraintestinal tissues. (
  • This is a collection of gene-gene interaction networks from various human tissues. (
  • The networks capture gene interactions that are specific to human tissues and cell lineages ranging from B lymphocyte to skeletal muscle and the whole brain. (
  • This study is the first report of the elucidation of ob gene expression in human tissues, thereby leading to better understanding of the physiological and clinical implications of the ob gene. (
  • a , RT-PCR with tankyrase-related clone-specific primers using cDNAs from different meningiomas and normal tissues. (
  • b , RT-PCR with β-actin-specific primers using the cDNAs from the same meningiomas and normal tissues as described in a . (
  • We have developed a versatile two-component system that overcomes these limitations, providing reliable, conditional gene activation in restricted tissues or cell types. (
  • Ceruloplasmin gene expression in the mammary gland was tissue-specific, with no evidence of expression in brain, heart or other extrahepatic tissues. (
  • Taken together, these data indicate that the mammary gland is a prominent site of extrahepatic ceruloplasmin gene expression and add to the evidence that ceruloplasmin biosynthesis is associated with growth and differentiation in non-hepatic tissues. (
  • We demonstrated that the hCMV-IE:eGFP transgene was expressed in numerous tissues but transgene expression was either regionalized or restricted to specific cell types as embryo and larval development progressed. (
  • Ubiquitin-specific protease 3 targets TRAF6 for deubiquitination and suppresses IL-1β induced chondrocyte apoptosis. (
  • But while most companies working in the field are focused on inhibiting a particular miRNA, and therefore all its gene targets, Dutch startup Stealth Biotech aims at blocking miRNA activity on specific genes. (
  • In this session, the third in the Precision Oncology News Virtual Molecular Tumor Board Series , our expert panelists will review patient cases in which genomic profiling has identified gene fusions that may or may not serve as druggable targets. (
  • This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets. (
  • Several nucleic acid amplification-based assays have been reported for S. aureus that are based on specific gene targets as well as universal sequences, offering different advantages and limitations ( 2 , 6 , 12 , 13 , 27 , 29 , 31 , 38 , 42 ). (
  • The company has begun enrolling patients with advanced solid tumors in its Phase 1 dose escalation study of NeoTCR-P1, an autologous gene-edited TCR T cell product that targets personalized neoantigens ( ). (
  • These genes and enriched motifs may represent targets for treatment or investigation of memory-related diseases. (
  • This suggests that the identified CS genes could be the direct or indirect targets of downy mildew effector proteins that promote disease susceptibility. (
  • Transcription factor that regulates gene expression in intestine. (
  • From the 17 identified CS genes, 6 belong to the ethylene response factor (ERF) family of transcription factor genes, suggesting that these ERF have a role during compatibility. (
  • One potential improvement would be to have clinical exome sequencing use methods designed to provide a maximum yield of all clinically relevant genes. (
  • However, gene-editing methodologies described to date for human cells suffer from technical limitations including limited target gene size, low targeting efficiency at transcriptionally inactive loci, and off-target genetic effects that could hamper broad clinical application. (
  • Previously, the presence of the Eap-encoding gene ( eap ) was determined to occur in only selected human clinical S. aureus isolates ( 19 , 20 ). (
  • Identifying these genes is important - not only for clinical care, but also for advancing our understanding of the neural circuits and processes involved in autism or in its core traits. (
  • One implication is that this information could be inappropriately incorporated into clinical decision making, including autism-specific gene panels or lists. (
  • Some authorities have advocated for such gene lists, and autism-specific gene sequencing panels have been marketed by clinical laboratories. (
  • And sequencing all of an individual's genes is superior to gene panels as a first-tier clinical test for people with autism or intellectual disability. (
  • In a first-of-its-kind clinical study, Baylor College of Medicine evaluated the safety, survival and anti-tumor activity of tumor-specific T cells rendered resistant to transforming growth factor β (TGFβ), in patients with Epstein Barr Virus (EBV) positive lymphoma. (
  • In an earlier clinical study of unmodified EBV-specific T cells, more than 50 percent of patients experienced complete remission, and tumor responses were observed in over 70 percent," said Rooney, who also is senior author on the current study. (
  • Accordingly, we wanted to identify genes that are characteristically expressed in the ECL cells and controlled by gastrin. (
  • Following leukapheresis, isolation of lymphocytes, expansion ex vivo, transduction, and introduction into the patient, the NY-ESO-1-specific TCR gene-transduced T lymphocytes TBI-1301 bind to NY-ESO-1 on tumor cells. (
  • Rather, gene expression profiles from tumor tissue are more commonly used along with clinicopathologic features to predict risk of progression or fatal disease. (
  • ERBB4 now joins a previously identified gene, NOTCH1, as a susceptibility gene for LVOT defects. (
  • These findings confirm our earlier research suggesting the existence of susceptibility genes that have sex-limited effects on the vulnerability of women to developing severe depression," said Dr. Zubenko. (
  • Taken together, our results support the observation that the association between VitD status and MS susceptibility is genotype dependent and suggest that the outcome of VitD status in MS is determined by gene-by-sex interactions. (
  • According to the 'less‐is‐more' hypothesis, human‐specific pseudogenes that are functional in related primates reveal insight into how gene loss helped shape human evolution. (
  • Among fixed and segregating human‐specific pseudogenes, chemoreception and immune response are over‐represented functional categories. (
  • Human Gene Patenting While researching texts written about genes the most interesting topic that came up was human gene patenting. (
  • Human gene patenting is one of hot topic in today's world and it could have a major effect for generations to come. (
  • The human insulin gene is now recombined with the bacterial DNA plasmid. (
  • Mary Ann Liebert, Inc. publishers is a privately held, fully integrated media company known for establishing authoritative peer-reviewed journals in many promising areas of science and biomedical research, including Human Gene Therapy, ASSAY and Drug Development Technologies, Applied In Vitro Toxicology, and DNA and Cell Biology. (
  • To identify specific genes, investigators examined the DNA of children treated for LVOT malformations and their parents, enrolled by Dr. McBride at Nationwide Children's Hospital or by Dr. John Belmont and his team in the Department of Molecular and Human Genetics, Baylor College of Medicine at Texas Children's Hospital. (
  • However, a new study to be reported to the annual conference of the European Society of Human Genetics (ESHG) today (Sunday) shows that exome sequencing, as currently performed, does not always produce high quality results when examining subsets of genes such as the 56 ACMG genes. (
  • Understanding multicellular function and disease with human tissue-specific networks. (
  • We confirmed this hypothesis on a dataset of more than 1,000 normal human tissue samples, where we found that our method predicts highly tissue-specific and functionally relevant interactions, whereas a global coexpression method only associates general TFs to non-specific biological processes. (
  • In this study, we isolated a full-length human ob complementary DNA (cDNA) clone and examined the tissue distribution of ob gene expression in humans. (
  • Combination of stem cell-based approaches with gene-editing technologies represents an attractive strategy for studying human disease and developing therapies. (
  • The Gene/Disease Specific Database Advisory Council is the Human Variome Project's representative body for Gene/Disease Specific Databases. (
  • Provide guidance and advice to the International Scientific Advisory Committee and Human Variome Project Board on matters concerning gene/disease specific collection and sharing of genetic variation information. (
  • Human peripheral blood T-lymphocytes transduced with a retroviral vector encoding a T-cell receptor (TCR) specific for the cancer-testis antigen NY-ESO-1, with potential antineoplastic activity. (
  • The discovery of a human-specific gene involved in such a fundamental process as the creation of a pluripotent cell, one that can become a variety of tissue types, surprised Yale researchers. (
  • First author Elizabeth Atkinson extracts DNA as part of her research on human gene FOXP2. (
  • FOXP2, a gene implicated in affecting speech and language, is held up as a textbook example of positive selection on a human-specific trait. (
  • Their analysis of genetic data from a diverse sample of modern people and Neanderthals saw no evidence for recent, human-specific selection of FOXP2 and revises the history of how we think humans acquired language. (
  • In the past five years, several archaic hominin genomes have been sequenced, and FOXP2 was among the first genes examined because it was so important and supposedly human specific," says first author Elizabeth Atkinson of Stony Brook University and the Broad Institute of Harvard and MIT. (
  • Atkinson and her colleagues assembled mostly publicly available data from diverse human genomes-both modern and archaic-and analyzed the entire FOXP2 gene while comparing it to the surrounding genetic information to better understand the context for its evolution. (
  • In the largest-scale human genetics study of its kind, researchers have identified seven new gene regions associated with individual variability in body fat traits. (
  • Ceruloplasmin gene expression was also detected in a human breast adenocarcinoma cell line and in biopsy tissue from women with invasive ductal carcinoma. (
  • Downregulation of the gene encoding Tensin3 (TNS3) in human renal cell carcinoma (RCC) may contribute to cancer cell metastatic behavior. (
  • The immediate early (IE) gene of the human cytomegalovirus is essential to the viral replication. (
  • Any accidental return of individuals of the species to its original habitats, through natural migration, environmental disruption (storms, floods, etc.), accidental human transportation, or purposeful relocation, could unintentionally drive the species to extinction if the relocated individuals carried harmful gene drives. (
  • The book also introduces the term meme for a unit of human cultural evolution analogous to the gene, suggesting that such "selfish" replication may also model human culture, in a different sense. (
  • Functional analysis revealed that Gtf2ird1 regulates not only M-cone opsin but also other photoreceptor-specific genes. (
  • not all inhibitory RNAs containing perfect homology with a target mRNA actually cause gene silencing. (
  • Next, we targeted a different genomic locus, the Drosophila melanogaster histone cluster, and identified several regulators of the essential histone locus and validated their functional association with genes within the locus. (
  • Functional analysis was performed by siRNA-mediated gene knockdown in primary murine retinal cells. (
  • In each network, nodes represent genes and edges represent tissue-specific functional associations between genes. (
  • Conditional and cell type-specific gene expression systems allow precise functional complementation of mutants, disclosing the spatial and temporal significance of a gene's expression profile at different stages in development. (
  • Eukaryotic genomes have evolved through numerous rearrangements, producing duplicated genes with functional redundancy, a characteristic that is particularly evident in plants. (
  • However, distinct residues within this region mediate specific interactions with TRPC1 or PKD1. (
  • Acute responses to meningeal CGRP are female-specific and sensitization to CGRP after two distinct stimuli are also female-specific. (
  • found that different stimuli elicited distinct lipid A modification profiles in Salmonella enterica serovar Typhimurium, although they promoted expression of the same set of genes encoding lipid A-modifying enzymes. (
  • However, based on the current evidence, it is misleading to promote these gene panels as being meaningfully distinct from gene panels for intellectual disability, or to omit established intellectual disability-linked genes from the evaluation of individuals with autism. (
  • Using stationary phase as the reference condition, we report a distinct transcriptome profile for bacteroids, containing 203 induced and 354 repressed genes. (
  • Although UPEC strains exist within the intestinal tract of humans, they are distinct from most diarrheagenic or commensal E. coli strains in that UPEC isolates possess specific factors that permit their successful transition from the intestinal tract to the urinary tract. (
  • These molecular analyses implicate a highly specific pattern of metabolic alterations in the PFC of subjects with schizophrenia and raise the possibility that antipsychotic medications may exert a therapeutic effect, in part, by normalizing some of these changes. (
  • Identifying proteins selectively associated with a genomic locus provides an important entry point toward understanding how a specific gene is regulated. (
  • The analysis helps researchers find the responsible genes by comparing the genetic codes of patients suffering from heart defects with the codes of those who did not. (
  • Ubiquitin-specific protease 3 promotes cell migration and invasion by interacting with and deubiquitinating SUZ12 in gastric cancer. (
  • Ubiquitin‑specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial‑mesenchymal transition. (
  • As described recently in Cell Reports , Kyoto University researchers have now identified a specific gene -- initially known to prevent autoimmune diseases -- as a key regulator in iron uptake. (
  • Now that it's clear this gene has an important role in regulating new brain cell growth, Zhang and his colleagues hope to investigate RAB39b's role in regulating neuron activity-dependent signaling networks, for further exploring the mechanism of autism spectrum disorder. (
  • One reaction is the transport of metals into specific cell sections, the vacuoles, in which heavy metals and other toxins are stored and thus rendered harmless. (
  • The female gametophyte is composed of four specific cell types: the synergids that attract pollen tubes, the egg cell and central cell which are fusion partners for the two sperm cells, and the antipodal cells whose function is unknown. (
  • These libraries represent diverse transcripts, potentially corresponding to 3,850 genes (contigs and singletons) from the female gametophyte and 963 genes (contigs and singletons) from the egg cell. (
  • These EST resources should prove useful for identifying female gametophyte or cell-specific genes. (
  • Decreased expression of proinflammatory genes was observed with high VitD in female CD4 T effector cells, specifically implicating a key role of MHC class II genes, interferon gamma, and Th1 cell-mediated neuroinflammation. (
  • In particular, inducible expression in F1 plants obtained from crosses of driver and effector lines allows for rapid assessment of the cell type-specific impact of an effector with high temporal resolution. (
  • Results: The expression of 365 genes was ECL cell characteristic. (
  • Conclusion: The ECL cell specific expression profile is reminiscent of that of neurons and other endocrine cells exhibiting high expression of genes encoding proteins involved in the synthesis, storage and secretion of neuropeptides or peptide hormones. (
  • The gene called CCNE1 is normally involved in cell cycling, but the variant CCNE1 does not appear to play that role and instead appears critical for reprogramming. (
  • In addition, genetic analysis in a mouse model suggests an important physiological role for two of these genes in fat cell development. (
  • This stimulation will train the T cells to kill EBV infected cells and result in the growth of an EBV specific T cell line. (
  • This mutant receptor can bind TGFβ but does not transmit an inhibitory signal and also blocks the inhibitory signaling of TGFβ through its normal receptor," said Dr. Cliona Rooney , professor of pediatrics, division of hematology and oncology and the Center for Cell and Gene Therapy at Baylor College of Medicine, Texas Children's Hospital and Houston Methodist Hospital. (
  • The doctor who oversaw my transplants knew of the T cell trial at the Center for Cell and Gene Therapy and referred me for treatment. (
  • Analysis of cell-type-specific markers showed a specific loss of V2 interneurons in the brain and spinal cord, likely arising from mis-specification of neural progenitors. (
  • Generally, homeopathic remedies do not contain any pharmacologically acting substances, therefore they must alter the health characteristics of an individual by interacting with the transcriptome (the number of genes that are expressed in any particular cell or tissue) and re-arranging the expression of various genes that effect those particular changes in health status. (
  • This system allows conditional tissue-specific ectopic gene expression and provides a tool for conditional cell type- or tissue-specific complementation of mutants. (
  • In such cases, a system that allows cell type-specific conditional complementation is invaluable. (
  • Such a system that could also allow conditional cell type-specific activation of randomly tagged genes would provide the versatility required to identify classes of mutants with tissue-specific effects or mutants with early lethal effects. (
  • Finally, the hCMV:eGFP transgenic lines described in the present study will be valuable tools to trace specific cell lineages in adult zebrafish. (
  • If the gene drive is already present in the egg cell (e.g. when received from one parent), all the gametes of the individual will carry the gene drive (instead of 50% in the case of a normal gene). (
  • Such complexity may be explained by the idea that individual TRPC proteins may differentially associate with additional proteins to produce specific functions. (
  • This set of so-called compatible specific (CS) genes contrasts with the large group of defense-associated genes that is differentially expressed during both compatible and incompatible interactions. (
  • The majority of CS genes are differentially regulated in response to various forms of abiotic stress. (
  • The results of this research, in combination with the characterization of a subset of the aforementioned weak ethylene insensitive mutants that are defective in the UPF genes (core-components of the nonsense-mediated mRNA decay machinery), uncovered a translation-based branch of the ethylene signaling pathway [2]. (
  • Ceruloplasmin mRNA was also detected in mammary gland tissue from male, virgin female and non-pregnant/multiparous animals, and the abundance of ceruloplasmin-specific transcripts in virgin female rats was independent of their stage of oestrus. (
  • Similarly, decreased folate levels can be associated with altered nucleic acid metabolism and altered gene expression ( 9 ). (
  • Certain previously described symbiosis-specific characteristics, such as the downregulation of amino acid metabolism genes, were no longer observed, indicating that these features are more likely due to the nongrowing state of bacteroids rather than representing bacteroid-specific physiological adaptations. (
  • Most systems to manipulate gene expression allow control of only one factor, space or time, and currently available systems that control both temporal and spatial expression of genes have their limitations. (
  • I understand that specific primers may be better for the cDNA synthesis. (
  • If I am not wrong, the gene-specific primer for first strand cDNA synthesis has to be located 3' of your PCR amplicon and antisense to the coding strand, similiar to oligo-dT primer. (
  • Different stimuli caused the genes to be activated with different kinetics, thus altering the temporal order in which the lipid A-modifying enzymes were produced. (
  • After several days, the researchers found that the daily activation cycle of Per genes in the SCN was not affected by the abnormal feeding pattern. (
  • Hspb1 knockdown in cKO chondrocytes can normalize abnormal expression of genes involved in chondrocyte differentiation such as Mmp13 . (
  • Viral gene transfer systems consisting of replication-deficient pseudo-type viruses which carry the VEGF on their envelope are suitable for the introduction of at least one gene into patients and can be applied in gene and tumour therapy. (
  • The use of biomaterials for gene delivery can potentially avoid many of the safety concerns with viral gene delivery. (
  • In response to viral infections, interferons (IFNs) upregulate the expression of hundreds of interferon-stimulated genes (ISGs), whose cumulative action can potently inhibit the replication of bunyaviruses. (
  • Through use of an infectious virus-like particle (VLP) assay (based on the BUNV minigenome system), we confirmed that gene expression from all 3 viral segments is strongly inhibited by ISG20. (
  • These viral gene drives can propagate a modification into the population of viruses, and aim to reduce the infectivity of the virus. (
  • Ubiquitin-specific protease 3 overexpression promotes gastric carcinogenesis and is predictive of poor patient prognosis. (
  • a href='/help/gene_ontology' target='_top'>More. (
  • Analysis of the predicted interactions suggested that it works best to infer context-specific TF-target interactions which only co-express locally. (
  • The remainder of MS risk is thought to come from environmental factors or gene-by-environment interactions. (
  • Here, we report on the identification of Arabidopsis genes that are induced during compatible but not during incompatible interactions with the downy mildew pathogen Hyaloperonospora arabidopsidis . (
  • siRNA-mediated gene knockdown of Gtf2ird1 suppresses M-cone opsin expression. (
  • 2008). In both NM and LGMD1C examples, it would be advantageous to restrict gene knockdown to the affected allele while leaving the normal allele unperturbed. (
  • Dawkins builds upon George C. Williams's book Adaptation and Natural Selection (1966), which argued that altruism is not based upon group benefit per se, but results from selection that occurs "at the level of the gene mediated by the phenotype" and that any selection at the group level occurred only under rare circumstances. (
  • Researchers have found that men and women with major depression have opposing changes in gene expression. (
  • As an example, the researchers found that women with major depression showed an increase in the expression of genes that influence the function of synapses, which are structures that enable communication between neurons. (
  • These genes are not rare, they are found in everyone. (
  • The rest of the molecule is thought to span the membrane 11 times, ending in a relatively short cytoplasmic tail that had been shown to interact with PKD2, the gene product of the second gene found to be responsible for ADPKD ( 7 , 8 ), and also to bind and activate heterotrimeric G i /G o proteins in vitro ( 9 ). (
  • Schematic representation (not to scale) of Eap and the encoding gene, showing the amino acid (aa) composition consisting of a 30-aa signal peptide (S) and 110-aa residue domains (R1, R2, … RX) found in multiple copies. (
  • Compared with exponentially growing cells, we found an extensive overlap of downregulated growth-associated genes during both symbiosis and stationary phase, confirming the essentially nongrowing state of nitrogen-fixing bacteroids in determinate nodules that are not terminally differentiated. (
  • CGH analysis revealed that 2,820 (52.4%) of these genes were common to all 11 E. coli strains, yet only 173 UPEC-specific genes were found by CGH to be present in all UPEC strains but in none of the fecal/commensal strains. (
  • The researchers found that individuals whose colons have high levels of a specific gene product - 15-hydroxyprostaglandin dehydrogenase (15-PGDH) RNA - dramatically reduce their chances of developing colorectal cancer by taking aspirin. (
  • An exhaustive analysis of factors that allow mature cells to become like embryonic stem cells again has revealed a spliced form of a gene found only in primates that greatly aids the reprogramming of mature cells. (
  • It is also unclear why the gene is found only in in primate cells. (
  • They also found that each of these remedies can re-arrange the expression of a range of quite different genes. (
  • We found that no raSNP mapped to a miRNA gene, suggesting that altered miRNA targeting is an unlikely mechanism involved in BC risk. (