The sequential location of genes on a chromosome.
The genetic complement of MITOCHONDRIA as represented in their DNA.
The presence of two or more genetic loci on the same chromosome. Extensions of this original definition refer to the similarity in content and organization between chromosomes, of different species for example.
Genes that are located on the MITOCHONDRIAL DNA. Mitochondrial inheritance is often referred to as maternal inheritance but should be differentiated from maternal inheritance that is transmitted chromosomally.
Any method used for determining the location of and relative distances between genes on a chromosome.
The process of cumulative change at the level of DNA; RNA; and PROTEINS, over successive generations.
The relationships of groups of organisms as reflected by their genetic makeup.
The ordered rearrangement of gene regions by DNA recombination such as that which occurs normally during development.
The genetic complement of an organism, including all of its GENES, as represented in its DNA, or in some cases, its RNA.
Double-stranded DNA of MITOCHONDRIA. In eukaryotes, the mitochondrial GENOME is circular and codes for ribosomal RNAs, transfer RNAs, and about 10 proteins.
An aberration in which a chromosomal segment is deleted and reinserted in the same place but turned 180 degrees from its original orientation, so that the gene sequence for the segment is reversed with respect to that of the rest of the chromosome.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A plant family of the order Campanulales, subclass Asteridae, class Magnoliopsida
The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME.
Structures within the nucleus of bacterial cells consisting of or containing DNA, which carry genetic information essential to the cell.
A multistage process that includes cloning, physical mapping, subcloning, determination of the DNA SEQUENCE, and information analysis.
In bacteria, a group of metabolically related genes, with a common promoter, whose transcription into a single polycistronic MESSENGER RNA is under the control of an OPERATOR REGION.
The functional hereditary units of BACTERIA.
Processes occurring in various organisms by which new genes are copied. Gene duplication may result in a MULTIGENE FAMILY; supergenes or PSEUDOGENES.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A phylum of metazoan invertebrates comprising the segmented worms, and including marine annelids (POLYCHAETA), freshwater annelids, earthworms (OLIGOCHAETA), and LEECHES. Only the leeches are of medical interest. (Dorland, 27th ed)
The small RNA molecules, 73-80 nucleotides long, that function during translation (TRANSLATION, GENETIC) to align AMINO ACIDS at the RIBOSOMES in a sequence determined by the mRNA (RNA, MESSENGER). There are about 30 different transfer RNAs. Each recognizes a specific CODON set on the mRNA through its own ANTICODON and as aminoacyl tRNAs (RNA, TRANSFER, AMINO ACYL), each carries a specific amino acid to the ribosome to add to the elongating peptide chains.
The genetic complement of a BACTERIA as represented in its DNA.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
The genetic complement of an archaeal organism (ARCHAEA) as represented in its DNA.
Deoxyribonucleic acid that makes up the genetic material of CHLOROPLASTS.
A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. A known set of conserved sequences is represented by a CONSENSUS SEQUENCE. AMINO ACID MOTIFS are often composed of conserved sequences.
Members of the phylum Arthropoda, composed of organisms having a hard, jointed exoskeleton and paired jointed legs. It includes the class INSECTS and the subclass ARACHNIDA, many species of which are important medically as parasites or as vectors of organisms capable of causing disease in man.
A set of genes descended by duplication and variation from some ancestral gene. Such genes may be clustered together on the same chromosome or dispersed on different chromosomes. Examples of multigene families include those that encode the hemoglobins, immunoglobulins, histocompatibility antigens, actins, tubulins, keratins, collagens, heat shock proteins, salivary glue proteins, chorion proteins, cuticle proteins, yolk proteins, and phaseolins, as well as histones, ribosomal RNA, and transfer RNA genes. The latter three are examples of reiterated genes, where hundreds of identical genes are present in a tandem array. (King & Stanfield, A Dictionary of Genetics, 4th ed)
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.
DNA constructs that are composed of, at least, a REPLICATION ORIGIN, for successful replication, propagation to and maintenance as an extra chromosome in bacteria. In addition, they can carry large amounts (about 200 kilobases) of other sequence for a variety of bioengineering purposes.
The complete gene complement contained in a set of chromosomes in a fungus.
Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses.
The genetic complement of CHLOROPLASTS as represented in their DNA.
A transfer RNA which is specific for carrying asparagine to sites on the ribosomes in preparation for protein synthesis.
The systematic study of the complete DNA sequences (GENOME) of organisms.
The genetic complement of a plant (PLANTS) as represented in its DNA.
An order of anaerobic, coccoid to rod-shaped methanogens, in the kingdom EURYARCHAEOTA. They are nonmotile, do not catabolize carbohydrates, proteinaceous material, or organic compounds other than formate or carbon monoxide, and are widely distributed in nature.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
The deletion and reinsertion of a segment of a nucleic acid sequence in the same place, but flipped in an opposite orientation.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Genes bearing close resemblance to known genes at different loci, but rendered non-functional by additions or deletions in structure that prevent normal transcription or translation. When lacking introns and containing a poly-A segment near the downstream end (as a result of reverse copying from processed nuclear RNA into double-stranded DNA), they are called processed genes.
Any of the DNA in between gene-coding DNA, including untranslated regions, 5' and 3' flanking regions, INTRONS, non-functional pseudogenes, and non-functional repetitive sequences. This DNA may or may not encode regulatory functions.
A transfer RNA which is specific for carrying cysteine to sites on the ribosomes in preparation for protein synthesis.
Theoretical representations that simulate the behavior or activity of genetic processes or phenomena. They include the use of mathematical equations, computers, and other electronic equipment.
A sequence of successive nucleotide triplets that are read as CODONS specifying AMINO ACIDS and begin with an INITIATOR CODON and end with a stop codon (CODON, TERMINATOR).
Overlapping of cloned or sequenced DNA to construct a continuous region of a gene, chromosome or genome.
The sequential correspondence of nucleotides in one nucleic acid molecule with those of another nucleic acid molecule. Sequence homology is an indication of the genetic relatedness of different organisms and gene function.
In a prokaryotic cell or in the nucleus of a eukaryotic cell, a structure consisting of or containing DNA which carries the genetic information essential to the cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Mapping of the linear order of genes on a chromosome with units indicating their distances by using methods other than genetic recombination. These methods include nucleotide sequencing, overlapping deletions in polytene chromosomes, and electron micrography of heteroduplex DNA. (From King & Stansfield, A Dictionary of Genetics, 5th ed)
A set of three nucleotides in a protein coding sequence that specifies individual amino acids or a termination signal (CODON, TERMINATOR). Most codons are universal, but some organisms do not produce the transfer RNAs (RNA, TRANSFER) complementary to all codons. These codons are referred to as unassigned codons (CODONS, NONSENSE).
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Antibiotic produced by Streptomyces pactum used as an antineoplastic agent. It is also used as a tool in biochemistry because it inhibits certain steps in protein synthesis.
Measurement of this acid in the urine after oral administration of histidine provides the basis for the diagnostic test of folic acid deficiency and of megaloblastic anemia of pregnancy.
Discrete segments of DNA which can excise and reintegrate to another site in the genome. Most are inactive, i.e., have not been found to exist outside the integrated state. DNA transposable elements include bacterial IS (insertion sequence) elements, Tn elements, the maize controlling elements Ac and Ds, Drosophila P, gypsy, and pogo elements, the human Tigger elements and the Tc and mariner elements which are found throughout the animal kingdom.
One of the largest orders of mostly marine CRUSTACEA, containing over 10,000 species. Like AMPHIPODA, the other large order in the superorder Peracarida, members are shrimp-like in appearance, have sessile compound eyes, and no carapace. But unlike Amphipoda, they possess abdominal pleopods (modified as gills) and their bodies are dorsoventrally flattened.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
The genetic complement of an insect (INSECTS) as represented in its DNA.
A method for ordering genetic loci along CHROMOSOMES. The method involves fusing irradiated donor cells with host cells from another species. Following cell fusion, fragments of DNA from the irradiated cells become integrated into the chromosomes of the host cells. Molecular probing of DNA obtained from the fused cells is used to determine if two or more genetic loci are located within the same fragment of donor cell DNA.
A phenotypically recognizable genetic trait which can be used to identify a genetic locus, a linkage group, or a recombination event.
Animals having a vertebral column, members of the phylum Chordata, subphylum Craniata comprising mammals, birds, reptiles, amphibians, and fishes.
A technique with which an unknown region of a chromosome can be explored. It is generally used to isolate a locus of interest for which no probe is available but that is known to be linked to a gene which has been identified and cloned. A fragment containing a known gene is selected and used as a probe to identify other overlapping fragments which contain the same gene. The nucleotide sequences of these fragments can then be characterized. This process continues for the length of the chromosome.
Sequences of DNA or RNA that occur in multiple copies. There are several types: INTERSPERSED REPETITIVE SEQUENCES are copies of transposable elements (DNA TRANSPOSABLE ELEMENTS or RETROELEMENTS) dispersed throughout the genome. TERMINAL REPEAT SEQUENCES flank both ends of another sequence, for example, the long terminal repeats (LTRs) on RETROVIRUSES. Variations may be direct repeats, those occurring in the same direction, or inverted repeats, those opposite to each other in direction. TANDEM REPEAT SEQUENCES are copies which lie adjacent to each other, direct or inverted (INVERTED REPEAT SEQUENCES).
The functional genetic units of ARCHAEA.
Plasmids containing at least one cos (cohesive-end site) of PHAGE LAMBDA. They are used as cloning vehicles.
The most abundant form of RNA. Together with proteins, it forms the ribosomes, playing a structural role and also a role in ribosomal binding of mRNA and tRNAs. Individual chains are conventionally designated by their sedimentation coefficients. In eukaryotes, four large chains exist, synthesized in the nucleolus and constituting about 50% of the ribosome. (Dorland, 28th ed)
Use of restriction endonucleases to analyze and generate a physical map of genomes, genes, or other segments of DNA.
The genetic complement of PLASTIDS as represented in their DNA.
Complex nucleoprotein structures which contain the genomic DNA and are part of the CELL NUCLEUS of PLANTS.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
Deliberate breeding of two different individuals that results in offspring that carry part of the genetic material of each parent. The parent organisms must be genetically compatible and may be from different varieties or closely related species.
Deoxyribonucleic acid that makes up the genetic material of bacteria.
A transfer RNA which is specific for carrying glutamic acid to sites on the ribosomes in preparation for protein synthesis.
A phylum of photosynthetic EUKARYOTA bearing double membrane-bound plastids containing chlorophyll a and b. They comprise the classical green algae, and represent over 7000 species that live in a variety of primarily aquatic habitats. Only about ten percent are marine species, most live in freshwater.
A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.
The spatial arrangement of the atoms of a nucleic acid or polynucleotide that results in its characteristic 3-dimensional shape.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The complete genetic complement contained in a DNA or RNA molecule in a virus.
Animals that have no spinal column.
The naturally occurring transmission of genetic information between organisms, related or unrelated, circumventing parent-to-offspring transmission. Horizontal gene transfer may occur via a variety of naturally occurring processes such as GENETIC CONJUGATION; GENETIC TRANSDUCTION; and TRANSFECTION. It may result in a change of the recipient organism's genetic composition (TRANSFORMATION, GENETIC).
The functional hereditary units of INSECTS.
Partial cDNA (DNA, COMPLEMENTARY) sequences that are unique to the cDNAs from which they were derived.
A genus of ascomycetous fungi of the family Saccharomycetaceae, order SACCHAROMYCETALES.
A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories for solving biological problems including manipulation of models and datasets.
Genotypic differences observed among individuals in a population.
The functional hereditary units of VIRUSES.
Proteins found in any species of bacterium.
Genes which regulate or circumscribe the activity of other genes; specifically, genes which code for PROTEINS or RNAs which have GENE EXPRESSION REGULATION functions.
The sequential set of three nucleotides in TRANSFER RNA that interacts with its complement in MESSENGER RNA, the CODON, during translation in the ribosome.
A phylum of the kingdom Metazoa. Mollusca have soft, unsegmented bodies with an anterior head, a dorsal visceral mass, and a ventral foot. Most are encased in a protective calcareous shell. It includes the classes GASTROPODA; BIVALVIA; CEPHALOPODA; Aplacophora; Scaphopoda; Polyplacophora; and Monoplacophora.
A serotype of Salmonella enterica that is a frequent agent of Salmonella gastroenteritis in humans. It also causes PARATYPHOID FEVER.
Members of the group of vascular plants which bear flowers. They are differentiated from GYMNOSPERMS by their production of seeds within a closed chamber (OVARY, PLANT). The Angiosperms division is composed of two classes, the monocotyledons (Liliopsida) and dicotyledons (Magnoliopsida). Angiosperms represent approximately 80% of all known living plants.
The addition of descriptive information about the function or structure of a molecular sequence to its MOLECULAR SEQUENCE DATA record.
A test used to determine whether or not complementation (compensation in the form of dominance) will occur in a cell with a given mutant phenotype when another mutant genome, encoding the same mutant phenotype, is introduced into that cell.
PASSERIFORMES of the suborder, Oscines, in which the flexor tendons of the toes are separate, and the lower syrinx has 4 to 9 pairs of tensor muscles inserted at both ends of the tracheal half rings. They include many commonly recognized birds such as CROWS; FINCHES; robins; SPARROWS; and SWALLOWS.
Functions constructed from a statistical model and a set of observed data which give the probability of that data for various values of the unknown model parameters. Those parameter values that maximize the probability are the maximum likelihood estimates of the parameters.
Databases devoted to knowledge about specific genes and gene products.
The meaning ascribed to the BASE SEQUENCE with respect to how it is translated into AMINO ACID SEQUENCE. The start, stop, and order of amino acids of a protein is specified by consecutive triplets of nucleotides called codons (CODON).
Proteins found in any species of virus.
Enzymes that are part of the restriction-modification systems. They catalyze the endonucleolytic cleavage of DNA sequences which lack the species-specific methylation pattern in the host cell's DNA. Cleavage yields random or specific double-stranded fragments with terminal 5'-phosphates. The function of restriction enzymes is to destroy any foreign DNA that invades the host cell. Most have been studied in bacterial systems, but a few have been found in eukaryotic organisms. They are also used as tools for the systematic dissection and mapping of chromosomes, in the determination of base sequences of DNAs, and have made it possible to splice and recombine genes from one organism into the genome of another. EC 3.21.1.
The female sex chromosome, being the differential sex chromosome carried by half the male gametes and all female gametes in human and other male-heterogametic species.
Sequential operating programs and data which instruct the functioning of a digital computer.
Chromosomes in which fragments of exogenous DNA ranging in length up to several hundred kilobase pairs have been cloned into yeast through ligation to vector sequences. These artificial chromosomes are used extensively in molecular biology for the construction of comprehensive genomic libraries of higher organisms.
Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503)
A genetic rearrangement through loss of segments of DNA or RNA, bringing sequences which are normally separated into close proximity. This deletion may be detected using cytogenetic techniques and can also be inferred from the phenotype, indicating a deletion at one specific locus.
One of the three domains of life (the others being BACTERIA and ARCHAEA), also called Eukarya. These are organisms whose cells are enclosed in membranes and possess a nucleus. They comprise almost all multicellular and many unicellular organisms, and are traditionally divided into groups (sometimes called kingdoms) including ANIMALS; PLANTS; FUNGI; and various algae and other taxa that were previously part of the old kingdom Protista.
The chromosomal constitution of a cell containing multiples of the normal number of CHROMOSOMES; includes triploidy (symbol: 3N), tetraploidy (symbol: 4N), etc.
Deoxyribonucleic acid that makes up the genetic material of plants.
Structures within the nucleus of fungal cells consisting of or containing DNA, which carry genetic information essential to the cell.
Sequences of DNA in the genes that are located between the EXONS. They are transcribed along with the exons but are removed from the primary gene transcript by RNA SPLICING to leave mature RNA. Some introns code for separate genes.
The functional hereditary units of PLANTS.
Annual cereal grass of the family POACEAE and its edible starchy grain, rice, which is the staple food of roughly one-half of the world's population.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
The homologous chromosomes that are dissimilar in the heterogametic sex. There are the X CHROMOSOME, the Y CHROMOSOME, and the W, Z chromosomes (in animals in which the female is the heterogametic sex (the silkworm moth Bombyx mori, for example)). In such cases the W chromosome is the female-determining and the male is ZZ. (From King & Stansfield, A Dictionary of Genetics, 4th ed)

Localization of psoriasis-susceptibility locus PSORS1 to a 60-kb interval telomeric to HLA-C. (1/1933)

Recent genome scans have established the presence of a major psoriasis-susceptibility locus in the human leukocyte antigen (HLA) complex on chromosome 6p21.3. To narrow the interval for candidate gene testing, we performed a linkage-disequilibrium analysis of 339 families, with the use of 62 physically mapped microsatellite markers spanning the major histocompatibility complex (MHC). As detected by use of the transmission/disequilibrium test (TDT), individual markers yielded significant linkage disequilibrium across most of the MHC. However, the strongest evidence for marker-trait disequilibrium was found in an approximately 300-kb region extending from the MICA gene to the corneodesmosin gene. Maximum-likelihood haplotypes were constructed across the entire MHC in the original sample and across a 1.2-Mb region of the central MHC in an expanded sample containing 139 additional families. Short (two- to five-marker) haplotypes were subjected to the TDT using a "moving-window" strategy that reduced the variability of TDT P values relative to the single-locus results. Furthermore, the expanded sample yielded a sharp peak of evidence for linkage disequilibrium that spanned approximately 170 kb and that was centered 100 kb telomeric to HLA-C. The 1.2-Mb interval was further dissected by means of recombinant ancestral haplotype analysis. This analysis identified risk haplotype 1 (RH1), which is a 60-kb fragment of ancestral haplotype 57.1, on all identifiable HLA risk haplotypes. One of these haplotypes exhibits significant linkage disequilibrium with psoriasis but does not carry Cw6, which is the HLA allele most strongly associated with the disease. These results demonstrate that RH1 is highly likely to carry the disease allele at PSORS1, and they exclude HLA-C and corneodesmosin with a high degree of confidence.  (+info)

Soggy, a spermatocyte-specific gene, lies 3.8 kb upstream of and antipodal to TEAD-2, a transcription factor expressed at the beginning of mouse development. (2/1933)

Investigation of the regulatory region of mTEAD-2, a gene expressed at the beginning of mouse pre-implantation development, led to the surprising discovery of another gene only 3.8 kb upstream of mTEAD-2. Here we show that this new gene is a single copy, testis-specific gene called SOGGY: (mSgy) that produces a single, dominant mRNA approximately 1.3 kb in length. It is transcribed in the direction opposite to mTEAD-2, thus placing the regulatory elements of these two genes in close proximity. mSgy contains three methionine codons that could potentially act as translation start sites, but most mSGY protein synthesis in vitro was initiated from the first Met codon to produce a full-length protein, suggesting that mSGY normally consists of 230 amino acids (26.7 kDa). Transcription began at a cluster of nucleotides approximately 150 bp upstream of the first Met codon using a TATA-less promoter contained within the first 0.9 kb upstream. The activity of this promoter was repressed by upstream sequences between -0.9 and -2.5 kb in cells that did not express mSgy, but this repression was relieved in cells that did express mSgy. mSgy mRNA was detected in embryos only after day 15 and in adult tissues only in the developing spermatocytes of seminiferous tubules, suggesting that mSgy is a spermatocyte-specific gene. Since mTEAD-2 and mSgy were not expressed in the same cells, the mSgy/mTEAD-2 locus provides a unique paradigm for differential regulation of gene expression during mammalian development.  (+info)

Automatic detection of conserved gene clusters in multiple genomes by graph comparison and P-quasi grouping. (3/1933)

We previously reported two graph algorithms for analysis of genomic information: a graph comparison algorithm to detect locally similar regions called correlated clusters and an algorithm to find a graph feature called P-quasi complete linkage. Based on these algorithms we have developed an automatic procedure to detect conserved gene clusters and align orthologous gene orders in multiple genomes. In the first step, the graph comparison is applied to pairwise genome comparisons, where the genome is considered as a one-dimensionally connected graph with genes as its nodes, and correlated clusters of genes that share sequence similarities are identified. In the next step, the P-quasi complete linkage analysis is applied to grouping of related clusters and conserved gene clusters in multiple genomes are identified. In the last step, orthologous relations of genes are established among each conserved cluster. We analyzed 17 completely sequenced microbial genomes and obtained 2313 clusters when the completeness parameter P: was 40%. About one quarter contained at least two genes that appeared in the metabolic and regulatory pathways in the KEGG database. This collection of conserved gene clusters is used to refine and augment ortholog group tables in KEGG and also to define ortholog identifiers as an extension of EC numbers.  (+info)

High-resolution transcript map of the region spanning D12S1629 and D12S312 at chromosome 12q13: triple A syndrome-linked region. (4/1933)

For those searching for human disease-causing genes, information on the position of genes with respect to genetic markers is essential. The physical map composed of ESTs and genetic markers provides the positional information of these markers as well as the starting point of gene identification in the form of genomic clones containing exons. To facilitate the effort of identification of genes in the region spanning D12S1629 and D12S312, we constructed a high-resolution transcript map with PAC/BAC/cosmid clones. The strategy for the construction of such a map involved utilization of STSs for the screening of the large insert bacterial chromosome libraries and a chromosome 12-specific cosmid library by hybridization. The contig was constructed based on the STS contents of the clones. The resulting high-resolution transcript map of the region between P273P14/SP6 and D12S312 spans 4.4 cM from 66.8 to 71.2 cM of the Genethon genetic map and represents approximately 2.4 Mb. It was composed of 81 BAC, 45 PAC, and 91 cosmid clones with a minimal tiling path consisting of 16 BAC and 4 PAC clones. These clones are being used to sequence this part of chromosome 12. We determined the order of 135 STSs including 74 genes and ESTs in the map. Among these, 115 STSs were unambiguously ordered, resulting in one ordered marker per 21 kb. The order of keratin type II locus genes was determined. This map would greatly enhance the positional cloning effort of the responsible genes for those diseases that are linked to this region, including male germ cell tumor as well as palmoplantar keratoderma, Bothnian-type, and triple A syndrome. This transcript map was localized at human chromosome 12q13.  (+info)

Developmentally regulated excision of a 28-base-pair sequence from the Paramecium genome requires flanking DNA. (5/1933)

The micronuclear DNA of Paramecium tetraurelia is estimated to contain over 50,000 short DNA elements that are precisely removed during the formation of the transcriptionally active macronucleus. Each internal eliminated sequence (IES) is bounded by 5'-TA-3' dinucleotide repeats, a feature common to some classes of DNA transposons. We have developed an in vivo assay to analyze these highly efficient and precise DNA excision events. The microinjection of a cloned IES into mating cells results in accurately spliced products, and the transformed cells maintain the injected DNA as extrachromosomal molecules. A series of deletions flanking one side of a 28-bp IES were constructed and analyzed with the in vivo assay. Whereas 72 bp of DNA flanking the eliminated region is sufficient for excision, lengths of 31 and 18 bp result in reduced excision and removal of all wild-type sequences adjacent to the TA results in complete failure of excision. In contrast, nucleotide mutations within the middle of the 28-bp IES do not prevent excision. The results are consistent with a functional role for perfect inverted repeats flanking the IES.  (+info)

Genomic organization and the promoter region of the round-spotted pufferfish (Tetraodon fluviatilis) CDC37 gene. (6/1933)

The CDC37 gene was isolated from a round-spotted pufferfish genomic library and characterized. This gene is composed of nine exons spanning 3.5 kb. Exon 1 contains the 5'-untranslated region and exon 2 contains the putative translation initiation site. By 5'-RACE (rapid amplication of cDNA ends) and sequence analysis, we deduced the promoter region for the CDC37 gene and found that it does not contain typical TATA or CCAAT box. The 1.8 kb DNA fragment upstream of the putative transcription initiation site contains numerous potential binding sites for transcription factors including CREB, E2A, Ets-1, GATA, NF-IL6 and PEA3. When this DNA fragment was placed upstream of the chloramphenicol acetyltransferase (CAT) reporter gene and transfected into a carp CF cell line, it could drive the synthesis of CAT enzyme four times more efficiently than the promoterless pCAT-Basic did. In addition, the CDC37 gene is linked to the TYK2 gene in a tail-to-head manner with a small intergenic region of 292 bp.  (+info)

Diversity in organization and the origin of gene orders in the mitochondrial DNA molecules of the genus Saccharomyces. (7/1933)

Sequencing of the Saccharomyces cerevisiae nuclear and mitochondrial genomes provided a new background for studies on the evolution of the genomes. In this study, mitochondrial genomes of a number of Saccharomyces yeasts were mapped by restriction enzyme analysis, the orders of the genes were determined, and two of the genes were sequenced. The genome organization, i.e., the size, presence of intergenic sequences, and gene order, as well as polymorphism within the coding regions, indicate that Saccharomyces mtDNA molecules are dynamic structures and have undergone numerous changes during their evolution. Since the separation and sexual isolation of different yeast lineages, the coding parts have been accumulating point mutations, presumably in a linear manner with the passage of time. However, the accumulation of other changes may not have been a simple function of time. Larger mtDNA molecules belonging to Saccharomyces sensu stricto yeasts have acquired extensive intergenic sequences, including guanosine-cytosine-rich clusters, and apparently have rearranged the gene order at higher rates than smaller mtDNAs belonging to the Saccharomyces sensu lato yeasts. While within the sensu stricto group transposition has been a predominant mechanism for the creation of novel gene orders, the sensu lato yeasts could have used both transposition- and inversion-based mechanisms.  (+info)

Nucleotide variation at the yellow gene region is not reduced in Drosophila subobscura: a study in relation to chromosomal polymorphism. (8/1933)

In contrast to Drosophila melanogaster and Drosophila simulans, the yellow (y) gene region of Drosophila subobscura is not located in a region with a strong reduction in recombination. In addition, this gene maps very close to the breakpoints of different inversions that segregate as polymorphic in natural populations of D. subobscura. Therefore, levels of variation at the y gene region in this species relative to those found in D. melanogaster and D. simulans may be affected not only by the change in the recombinational environment, but also by the presence of inversion polymorphism. To further investigate these aspects, an approximately 5.4-kb region of the A (=X) chromosome including the y gene was sequenced in 25 lines of D. subobscura and in the closely related species Drosophila madeirensis and Drosophila guanche. The D. subobscura lines studied differed in their A-chromosomal arrangements, A(st), A(2), and A(1). Unlike in D. melanogaster and D. simulans, levels of variation at the y gene region of D. subobscura are not reduced relative to those found at other genomic regions in the same species (rp49, Acp70A, and Acph-1). This result supports the effect of the change in the recombinational environment of a particular gene on the level of neutral variation. In addition, nucleotide variation is affected by chromosomal polymorphism. A strong genetic differentiation is detected between the A(1) arrangement and either A(st) or A(2), but not between A(st) and A(2). This result is consistent with the location of the y gene relative to the breakpoints of inversions A(1) and A(2). In addition, the pattern of nucleotide polymorphism in A(st)+A(2) and A(1) seems to point out that variation at the y gene region within these chromosomal classes is in the phase transient to equilibrium. The estimated ages of these arrangements assuming a star genealogy indicate that their origin cannot predate the D. madeirensis split. Therefore, the present results are consistent with a chromosomal phylogeny where Am(1), which is an arrangement present in D. madeirensis but absent in current populations of D. subobscura, would be the ancestral arrangement.  (+info)

Inversions are classified based on their location along the chromosome:

* Interstitial inversion: A segment of DNA is reversed within a larger gene or group of genes.
* Pericentric inversion: A segment of DNA is reversed near the centromere, the region of the chromosome where the sister chromatids are most closely attached.

Chromosome inversions can be detected through cytogenetic analysis, which allows visualization of the chromosomes and their structure. They can also be identified using molecular genetic techniques such as PCR (polymerase chain reaction) or array comparative genomic hybridization (aCGH).

Chromosome inversions are relatively rare in the general population, but they have been associated with various developmental disorders and an increased risk of certain diseases. For example, individuals with an inversion on chromosome 8p have an increased risk of developing cancer, while those with an inversion on chromosome 9q have a higher risk of developing neurological disorders.

Inversions can be inherited from one or both parents, and they can also occur spontaneously as a result of errors during DNA replication or repair. In some cases, inversions may be associated with other genetic abnormalities, such as translocations or deletions.

Overall, chromosome inversions are an important aspect of human genetics and can provide valuable insights into the mechanisms underlying developmental disorders and disease susceptibility.

Polyploidy is a condition where an organism has more than two sets of chromosomes, which are the thread-like structures that carry genetic information. It can occur in both plants and animals, although it is relatively rare in most species. In humans, polyploidy is extremely rare and usually occurs as a result of errors during cell division or abnormal fertilization.

In medicine, polyploidy is often used to describe certain types of cancer, such as breast cancer or colon cancer, that have extra sets of chromosomes. This can lead to the development of more aggressive and difficult-to-treat tumors.

However, not all cases of polyploidy are cancerous. Some individuals with Down syndrome, for example, have an extra copy of chromosome 21, which is a non-cancerous form of polyploidy. Additionally, some people may be born with extra copies of certain genes or chromosomal regions due to errors during embryonic development, which can lead to various health problems but are not cancerous.

Overall, the term "polyploidy" in medicine is used to describe any condition where an organism has more than two sets of chromosomes, regardless of whether it is cancerous or non-cancerous.

Some research on gene orders in animals' mitochondrial genomes reveal that the mutation rate of gene orders is not a constant ... Gene orders are the permutation of genome arrangement. A fair amount of research has been done trying to determine whether gene ... Grusea, Simona (September 2010). "Measures for the exceptionality of gene order in conserved genomic regions". Advances in ... orders evolve according to a molecular clock (molecular clock hypothesis) or in jumps (punctuated equilibrium). ...
"Order of Canada". Office, Privy Council; privé, Bureau du Conseil. "Privy Council Office". " ... Eugene Forsey, Canada's Maverick Sage. Toronto: Dundurn, 2012. Hodgetts, J.E. The Sound of One Voice: Eugene Forsey and His ... Appendix 3: Two Constitutional Scholars: Sir Kenneth Wheare and Dr Eugene Forsey. Milligan, Frank (2004). Eugene A. Forsey: An ... "Library and Archives Canada, Finding aid to Eugene Forsey fonds, part 2" (PDF). Retrieved 2020-06-18. Eugene Forsey - ...
John Lowery (February 2021). "America's Most Unsung Hero: Eugene James Bullard". Order of Daedalians. Dominick Pisano (October ... France Eugene Bullard (1895-1961) New Georgia Encyclopedia Eugene J. Bullard Smithsonian National Air and Space Museum Eugene ... Eugene Jacques Bullard (born Eugene James Bullard; October 9, 1895 - October 12, 1961) was one of the first black American ... Wikimedia Commons has media related to Eugene Bullard. James Eugene Bullard Base des Personnels de l'aéronautique militaire, ...
Christopher Scharpf; Kenneth J. Lazara (15 June 2019). "Order BELONIFORMES (Needlefishes)". The ETYFish Project Fish Name ... Seth Eugene Meek (April 1, 1859, Hicksville, Ohio - July 6, 1914, Chicago) was an American ichthyologist at the Field Museum of ... As is the Mezquital pupfish (Cyprinodon meeki). Category:Taxa named by Seth Eugene Meek Britz, Ralf (2007). "Review of ... Committee on Memorials, American Society of Zoologists (1916). "Seth Eugene Meek". Science. New Series. 43 (1100): 141. v t e ( ...
"OPINION & ORDER in re: WORLDCOM, INC. SECURITIES LITIGATION 02 Civ. 3288 (DLC) Denise Cote, United States District Judge" (PDF ... Eugene Morse is an American internal auditor and whistleblower who uncovered massive accounting fraud at WorldCom in 2002. ... "OPINION & ORDER 02 Civ. 3288 (DLC) Denise Cote, United States District Judge Page 24" (PDF). Retrieved May 6, 2008. "Lead ... "OPINION & ORDER 02 Civ. 3288 (DLC) Denise Cote, United States District Judge Page 25" (PDF). Retrieved May 6, 2008. (Articles ...
"Order of Canada citation". Retrieved 29 November 2021. "Hon. Eugene F. Whelan". Ontario Agricultural Hall of Fame. Archived ... Eugene Whelan - Parliament of Canada biography "Eugene WHELAN: Obituary". Windsor Star. Retrieved 22 February 2013. "Eugene ... There is a Eugene F. Whelan fonds at Library and Archives Canada. "Former Liberal cabinet minister Eugene Whelan dead at 88". ... "Eugene F. Whelan fonds, Library and Archives Canada". Eugene Whelan; Rick Archbold (1986). Whelan: The Man in the Green Stetson ...
University Microfilms order no. UMI00427744. Ward, Stephen, "New leader hopes to improve Newfoundland NDP's fortunes," Globe ... Long, Gene. Suspended state : Newfoundland before Canada / Gene Long. St. John's, Nfld. : Breakwater Books, 1999. 218 p. ; 21 ... Gene Long (born 1957) is a former politician in Newfoundland and Labrador, Canada. He was elected in 1986 as the New Democratic ... ISBN 1-55081-144-4 Long, Gene. William Coaker and the loss of faith: toward and beyond consensus in the suspension of ...
This model is formally closer to a higher order recurrent neural network. The same model has also been used to mimic the ... Nodes still represent genes and connections between them regulatory influences on gene expression. Genes in biological systems ... Other work has focused on predicting the gene expression levels in a gene regulatory network. The approaches used to model gene ... In another model of gene regulator networks evolution, the ratio of the frequencies of gene duplication and gene deletion show ...
"Eugene Reimer Order Of Canada". The Governor General of Canada. Retrieved 28 September 2017. (Articles with short ... Eugene "Gene" Reimer CM (21 January 1940 - 9 June 2008) was a Canadian wheelchair Paralympic athlete who won 10 Paralympic ... "Eugene Reimer - Obituary". The Abbotsford News. 9 June 2008. Retrieved 27 September 2017. "Hero In You Student Area - Eugene ... "Eugene "Gene" Reimer". Canadian Wheelchair Sports Association. Retrieved 28 September 2017. "History of Wheelchair ...
Kingman, Eugene (March 25, 1931). "The Old Order Changeth" (Cartoon). The Yale Record. New Haven: Yale Record. "Throwback ... "Eugene Kingman". Retrieved 20 June 2016. "New home for old view of world;It spent four decades at New York ... Eugene Kingman (1909-1975) was an American cartographer, painter, muralist, teacher and museum director. Kingman was born in ... From an early age, Eugene Kingman painted landscapes. He worked in a high contrast manner, putting highlights and shade next to ...
... have cited Genes, Brain and Behavior most often, are (in order of descending citation frequency) PLoS ONE, Genes, Brain and ... Holmes, Andrew (2012). "Genes, Brain and Behavior: At the vanguard of behavioral and genomic neuroscience". Genes, Brain and ... "Genes, Brain and Behavior: Overview". Wiley Online Library. Wiley-Blackwell. Retrieved 20 September 2013. "Genes, Brain and ... "Source details: Genes, Brain and Behavior". Scopus preview. Elsevier. Retrieved 28 January 2017. "Genes, Brain and Behavior". ...
In 2011, Levy was made a Member of the Order of Canada "for his contributions as a comic actor and writer, and for his ... Eugene Levy at IMDb Eugene Levy discography at Discogs Article at Eugene Levy on Twitter (Articles ... "Eugene Levy: 2008 Lifetime Artistic Achievement (Broadcasting)". Retrieved September 10, 2018. "ACTRA to give Eugene Levy Award ... Eugene Levy's brother Fred is also a producer on the show. Levy married Deborah Divine in 1977. Divine's career has been in TV ...
A felt sense is more ordered than concepts and has its own properties, different from those of logic; for example, it is very ... Eugene Tovio Gendlin (born Eugen Gendelin; 25 December 1926 - 1 May 2017) was an American philosopher who developed ways of ... Gendlin, Eugene T. (1991). "Thinking beyond patterns: body, language, and situations". In Ouden, Bernard D. den; Moen, Marcia ( ... Living is an intricate, ordered interaction with the environment, and as such, is a kind of knowing. Abstract knowledge is a ...
Petition," "Nomination," "Not Designated," and "Court Order". Although he was not on the California and Wyoming ballots, he was ... Get Clean For Gene: Eugene McCarthy's 1968 Presidential Campaign - George Rising Sandbrook, Dominic (December 18, 2007). Eugene ... Eugene McCarthy from 1916 to 2005 Eugene McCarthy's 1968 announcement speech A 1968 McCarthy for President brochure "Gene ... "Eugene McCarthy Public Service Award". The Eugene J. McCarthy Center. Archived from the original on October 6, 2014. Retrieved ...
Gómez MJ, Cases I, Valencia A (2004). "Gene order in Prokaryotes: conservation and implications". In Vicente M, Tamames J, ... some genes may be lost. Loss of genes is dependent of the number of genes originating in the gene cluster. In the four gene ... A gene family is a set of homologous genes within one organism. A gene cluster is a group of two or more genes found within an ... An example of a gene cluster is the Hox gene, which is made up of eight genes and is part of the Homeobox gene family. ...
Member of the Order of Australia (2010); Officer of the 'Ordre des Arts et des Lettres (2016); and previously the Chevalier ... Sherman, Gene (3 May 2016). "Ceremony Speech". University of Technology, Sydney. Retrieved 25 February 2019. "Dr Gene Sherman ... Gene Sherman AM (born 1947) is a philanthropist, academic and expert on art, fashion and architecture. In 2018, she founded the ... "Honorary Awards: Dr Gene Sherman". University of Sydney. 17 February 2015. Retrieved 14 February 2019. Russell, Leigh (16 June ...
"White Light CD/SACD (Pre-Order) - Intervention Records". Retrieved 2018-05-16. Jurek, Thom. "White ... White Light, aka Gene Clark, is the second solo album by Gene Clark, former member of The Byrds. It only achieved commercial ... Now this is classic rock." All tracks are written by Gene Clark, except where noted. Musicians Gene Clark - vocals, acoustic ... Gene Clark albums, A&M Records albums, Albums recorded at A&M Studios). ...
... ordered all such slaves to be immediately set free. Eugene went on to say that, "If this is not done when the fifteen days have ... Eugene died in Rome on 23 February 1447 and was buried at Saint Peter's by the tomb of Pope Eugene III. Later his tomb was ... and followed this with an order to suspend further conquest in order to allow the Franciscans to continue their work peacefully ... Eugene IV signed an agreement with the Armenians on 22 November 1439, and with a part of the Jacobites of Syria in 1443, and in ...
He later made statements indicating that he may have been attempting to fake mental illness in order to receive a more lenient ... Larry Gene Bell was born in Ralph, Alabama and had three sisters and one brother. The family reportedly moved frequently. Bell ... "Larry Gene Bell: The Murders of Shari Smith and Debra Helmick". Talk Murder With Me. December 27, 2020. Retrieved April 15, ... Larry Gene Bell (October 30, 1949 - October 4, 1996) was an American murderer and suspected serial killer in Lexington County, ...
He was a right-handed middle-order batsman. A former Windwards under-19s player, Eugene made his senior debut for the Windward ... List A matches played by John Eugene - CricketArchive. Retrieved 31 December 2015. First-class matches played by John Eugene - ... Eugene played his final first-class matches for the Windwards during the 2002-03 Carib Beer Cup, and his final List A matches ... Eugene missed several seasons in the late 1990s, but returned to form in the 2000-01 Busta Cup, scoring 406 runs from seven ...
Each cassette usually contains a single gene and tends to be very small; on the order of 500-1000 base pairs. They may exist ... In biology, a gene cassette is a type of mobile genetic element that contains a gene and a recombination site. ... Gene cassettes containing antibiotic resistance genes, or other virulence factors such as exotoxins, can be transferred from ... The mobile units that insert into integrons are gene cassettes. For cassettes that carry a single gene without a promoter, the ...
Order of Battle of the US Army - WWII - ETO. Washington, DC: U.S. Army Center of Military History. Retrieved July 8, 2020. ... Their children included son Eugene and daughter Marianna. Eugene M. Landrum Jr. (1920-2009) was a lieutenant colonel in the ... page 33 Eugene M. Landrum, Jr. at Find A Grave Archived 2017-09-16 at the Wayback Machine Eugene M. Landrum at Find A Grave ... entry for Eugene M. Landrum 1940 United States Federal Census, entry for Eugene M. Landrum "Jefferson Barracks: Social Items ...
In order to restrict expression to a specific cell type, a tissue-specific or cell-type specific promoter can be used. For ... Immune response to gene therapy vectors is what has caused previous attempts at gene therapy to fail, and is considered a key ... In retinal gene therapy, the most widely used vectors for ocular gene delivery are based on adeno-associated virus. The great ... Retina Gene therapy Retinitis pigmentosa Macular degeneration Gene therapy for color blindness Maguire A. M.; Simonelli F.; ...
p. 255 "Gene Kelly Made 1A on President's Order". Star Tribune. United Press. 14 October 1944. p. 1. Retrieved 28 September ... Gene Kelly at IMDb Gene Kelly at the TCM Movie Database Gene Kelly at the Internet Broadway Database The Gene Kelly Awards - ... University of Pittsburgh Naval Intelligence File on Gene Kelly Gene Kelly - An American Life - PBS Gene Kelly - Pittsburgh ... "Gene Kelly: cultural icon". Catholic New Times. 2005. Archived from the original on 2012-01-19. Yudkoff, Alvin Gene Kelly: A ...
... provides a system of transcriptional regulation with greater diversity of gene targets. Max must dimerise in order to be ... This gene has been shown mutated in cases of hereditary pheochromocytoma. More recently the Max gene becomes mutated and ... "Entrez Gene: MAX MYC associated factor X". Ecevit, O; Khan, MA; Goss, DJ (30 March 2010). "Kinetic analysis of the interaction ... MAX (also known as myc-associated factor X) is a gene that in humans encodes the MAX transcription factor. The protein product ...
War Department, General Order No. 12, 17 January 1919." After retiring from the military, Bradley wrote for medical journals ... Alfred Eugene Bradley, M.D. (November 25, 1864 - December 17, 1922) was a career surgeon that served in the United States Army ... ISBN 0-8379-3201-7 OCLC 657162692 "Brigadier General Alfred Eugene Bradley". U.S. Army Medical Department: Office of Medical ... ISBN 0837932017 OCLC 657162692 Alfred Eugene Bradley at Find a Grave (Articles with short description, Short description is ...
I hereby reject the order to report for induction." On May 18, 1964, he and two friends signed a "Pact" to insist upon joint ... Keyes, Gene. "World Second Language, Esperanto". Gene Keyes. Keyes, Gene (January 1981). "Strategic Nonviolent ... Gene Keyes Website Cahill-Keyes World Map and B.J.S. Cahill Resource: articles and resources compiled by Gene Keyes World ... Gene Keyes. Retrieved Oct 27, 2016. Stockton, Nick (Dec 9, 2013). "Get to Know a Projection: Gene Keyes' 40-Year Quest for the ...
"Arranging the Join Order: the Wong-Youssefi algorithm (INGRES)". M. Tamer Özsu; Patrick Valduriez (2011). Principles of ... optimization ... algorithm of INGRES [Wong and Youssefi, 1976] "Eugene Wong - Convocation". "Ph.D. Dissertations - Eugene Wong ... "Eugene Wong". EECS at UC Berkeley. Retrieved 27 December 2021. "IEEE Founders Medal Recipients". Retrieved 26 June ... Eugene Wong (born December 24, 1934 in Nanking, China) is a Chinese-American computer scientist and mathematician. Wong's ...
... may become an important diagnostic test. The human genome contains on the order of 25,000 genes which ... Gene sets are groups of genes that are functionally related according to current knowledge. Therefore, gene set analysis is ... Commonly used gene sets include those derived from KEGG pathways, Gene Ontology terms, gene groups that share some other ... Representative gene set analysis methods include Gene Set Enrichment Analysis (GSEA), which estimates significance of gene sets ...
Stolberg SG (22 January 2000). "Gene Therapy Ordered Halted At University". The New York Times. Retrieved 10 November 2010. ... Gene doping is not known to occur, but multiple gene therapies may have such effects. Kayser et al. argue that gene doping ... Gene therapy may be classified into two types: In somatic cell gene therapy (SCGT), the therapeutic genes are transferred into ... "Gene & Cell Therapy FAQs , ASGCT - American Society of Gene & Cell Therapy , ASGCT - American Society of Gene & Cell Therapy". ...
In order to invest in such assets he first helped to create those assets by becoming a venture capitalist of venture ... This career move was suggested by a Salomon Brothers investment banker and Yale alumni, Gene Dattel, who was deeply impressed ...
Observe and think in order to discover the truth. Do not believe what is contrary to reason and never deceive yourself or ... 60 (January 29, 1906), p. 6. Eugene V. Debs, "Socialist Sunday School," Socialist News [Cleveland], vol. 1, no. 40 (September 4 ...
Pilack, M. (2020). "Kronohero Report - in chronological order, science and hobby". Retrieved 19 June 2022. (Articles with short ... Taxa named by Seth Eugene Meek, Taxa named by Samuel Frederick Hildebrand, Fish described in 1913). ... based on sequences of the cytochrome b gene". Molecular Phylogenetics and Evolution. 43 (1): 91-110. ...
See Gene Quinn, SCOTUS Blog founder asks Supreme Court to reconsider Mayo ruling in Sequenom v. Ariosa , IP Watchdog (Mar. 21, ... 2015).[bare URL PDF] According to the patent, fetal DNA is ...
Chapman by threatening his children, but Henry throws it on the ground, writes a new one, and orders Riley to deliver it when ... Siskel, Gene (June 19, 1975). "'Benji' presents life at ground level". Chicago Tribune. Section 3, p. 7. Gross, Linda (November ... Gene Siskel gave the film two-and-a-half stars out of four, calling it "agreeable" but criticizing "a few cheap grabs for ...
... is a family of flowering plants in the eudicot order Malpighiales. It is most closely related to the family ... "Phylogenetics of seed plants: an analysis of nucleotide sequences from the plastid gene rbcL." Annals of the Missouri Botanical ... "An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III". Botanical ... "Molecular phylogenetics of Phyllanthaceae inferred from five genes (plastid atpB, matK, 3'ndhF, rbcL, and nuclear PHYC)". Mol. ...
Ufuk Talay Mark Hughes The list is ordered first by date of debut, and then if necessary in alphabetical order. Appearances as ... Eugene Sseppuya has scored 2 goals in his 7 appearances for the Uganda national football team. Shane Stefanutto has 3 Socceroos ...
Gene. 394 (1-2): 78-86. doi:10.1016/j.gene.2007.02.009. PMID 17383832. Lin T, Suttle DP (May 1995). "UMP synthase activity ... There must be an energy balance between the peptide new order and hydrogen bond formation in the loop, between the loop and the ... In humans, the gene that codes for this enzyme is located on the long arm of chromosome 3 (3q13). This bifunctional enzyme has ... However important the fusion order is, the evolutionary origin of each catalytic domain in UMPS is also a matter of study. Both ...
Track list of Kakihara's Songs (in order of performance)*: 1. my life my time 2. Electric Monster 3. Endless Journey Kiramune ... About Behind-the-scenes with shooting of CD cover art of Kakihara's Continuous album Seiyu Animedia March 2012 issue Comic Gene ... Track list of Kakihara's Songs (in order of performance)*: 1.adrenaline 2.Good Luck 3.Chaos Breaker 4.Labyrinth 5.Bible of ...
... director Eugene Tenenbaum and chairman Bruce Buck were reportedly already seeking a replacement for Grant the day after the ... police arrested 12 people on public order offences, while one man was arrested for grievous bodily harm, drink driving and ...
Order: UK), fictional character from Law & Order: UK Ronnie Baker Brooks (born 1967), American blues guitarist Rory and ... American football player Eugene C. Brooks (1871-1947), American educator Farmer Brooks, Canadian professional wrestler Foster ... American football player Nathan Eugene Brooks (1933-2020), American boxer Nathan C. Brooks, American educator Ned Brooks, ... Jamaican Association football player Gene Edward Brooks (1931-2004), American judge George Brooks (disambiguation), several ...
In this technique, a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to " ... These displaying phages can then be screened against other proteins, peptides or DNA sequences, in order to detect interaction ... A versatile screening system for selective isolation of genes by specific gene-product/ligand interaction". Eur. J. Biochem. ... Parmley SF, Smith GP (1988). "Antibody-selectable filamentous fd phage vectors: affinity purification of target genes". Gene. ...
Next in order comes tenancy in fee tail, the various classes of which are sketched by Littleton with brevity and accuracy; but ... Eugene Wambaugh wrote a learned introduction to the 1903 edition of The Tenures (Washington). Baker 2004. Shaw, William Arthur ... In other words, in order to acquire over lands powers unknown to the common law, the lands had been conveyed to feoffees who ... After discussing, in their logical order, other freehold interests in land, he passes to interests in land that were called by ...
Block, Eugene B. (July 1911). "Fighting the Opium Ring". The Overland Monthly. p. 184. "Knox Seems Barred From the Cabinet". ... The Namibian village of Schuckmannsburg was established by Captain Kurt Streitwolf in order to claim the Caprivi Strip, a 450 ...
Officers of the Order of the British Empire, Laurence Olivier Award winners, People from Walthamstow, Tony Award winners, LGBT ... Royal Conservatoire of Scotland 2016 The Gene Kelly Legacy Award from Dizzy Feet Foundation 2016 Critics' Circle Distinguished ... The Car Man 2001 Officer of the Order of the British Empire (OBE) for Services to Dance 2003 Hamburg Shakespeare Prize For The ...
... it is generally because gene regulatory proteins of the E2F family have become unrestrained and increase G1/S cyclin gene ... In order for the cell to continue through the G1-pm, there must be a high amount of growth factors and a steady rate of protein ... Sufficient nucleotides and amino acids must be present in order to synthesize mRNA and proteins. Physiological temperatures are ... switch on cell cycles events at the corrected time and in the correct order to prevent any mistakes. There are three ...
Judge Brown ordered him to take down such information as to their identities that he had posted, holding him in contempt, and ... Residents urged an end to the occupation as did rallies held by opponents in Eugene and Portland, Oregon, and in Idaho. On ... He was also ordered to pay $7,000 in restitution. Examples of damage caused by the militants Following the surrender of the ... Both of the Bundy brothers had been ordered to be held without bail in January when they were charged. After the judge ...
He needs to harvest his crop soon in order to keep the farm financially solvent. A small-time hood, Bobby Kopas (Paul Koslo), ... Al Lettieri as Frank Renda Linda Cristal as Nancy Chavez Lee Purcell as Wiley Paul Koslo as Bobby Kopas Taylor Lacher as Gene ... He arranges for Kopas to drop the assault charges against Majestyk, and orders his men to find the "melon picker" so he can ...
PTGS2 gene upregulation has also been linked with multiple stages of human reproduction. Presence of gene is found in the ... first-order processes, which means that PGHS-2 peroxidase or PTGS activities fall to zero within 1-2 minutes, even in the ... 2014, doi:10.1186/1471-2393-14-241 Li Y, He W, Liu T, Zhang Q (December 2010). "A new cyclo-oxygenase-2 gene variant in the Han ... "Prostaglandin pathway gene expression in human placenta, amnion and choriodecidua is differentially affected by preterm and ...
Maddeus, Gene (April 20, 2022). "Johnny Depp: Disney Wanted to Cut Ties on 'Pirates of the Caribbean' 'To Be Safe'". Variety. ... Henry intends to recruit Captain Jack Sparrow to help find it, but Will believes this is impossible and orders Henry to leave. ... though he later declined in order to focus on his television series Detectorists. He said he had felt "pangs of nostalgia" when ...
These traits, along with enlarged groups of genes relating to detoxification, the immune system, and growth and reproduction, ... American Cockroach at Earthling Nature Gallery of cockroaches Order Blattodea, Exploring California Insects University of ...
Danielson, Eugene; Turner, David; Elwart, Joseph; Bryzik, Walter (1 March 1993). "Thermomechanical Stress Analysis of Novel Low ... Similarly, it is usually desirable to minimize the number of heat transfer stages in order to maximize the temperature ... Schwarz, Ernest; Reid, Michael; Bryzik, Walter; Danielson, Eugene (1 March 1993). "Combustion and Performance Characteristics ... and quietness in order to achieve slightly higher reliability; the consequences of a broken airplane engine are so severe, even ...
From that point, the viewers see a montage of the events in the movie, some of which were previously shown out of order. The ... Films shot in Eugene, Oregon, American drama films, 2000s English-language films, 2000s American films). ... when the main characters are still at college in Eugene, Oregon. Alec's in the Administration and Records Office at his college ...
At Guantánamo Bay, officials ordered residents at the naval base to evacuate to storm shelters. Large ships at the port there ... Ben Funk (1967-05-24). "Hurricane Pilots Await Castro's OK". Eugene Register-Guard. Associated Press. Retrieved 2013-02-22. " ... Throughout eastern Cuba, Premier Fidel Castro ordered about 125,000 people to evacuate in low-lying areas, mostly in Oriente ...
Brevet Colonel Eugene B. Beaumont - Medal of Honor recipient. Brevet Colonel Stephen P. Corliss - Medal of Honor recipient. ... War Military Order of Foreign Wars Naval Order of the United States Naval and Military Order of the Spanish War Military Order ... The Military Order of the Loyal Legion of the United States (MOLLUS), or simply the Loyal Legion is a United States patriotic ... Originally, the Order was composed of three classes of members: Officers who had fought in the Army, Navy, or Marine Corps of ...
... seems like a cover for a religious-type belief system which has been prettified in order to be secular and even scientific." ... a change process developed by philosopher Eugene Gendlin, supports the theory that progress in psychotherapy is dependent on ...
Don Juan de Oñate, a New Spain-born conquistador of Spanish parents, was an expedition leader who ordered a big feast north of ... Railroad and Transportation Museum of El Paso The Gene Roddenberry Planetarium Lynx Exhibits Ysleta Mission is recognized as ... "The Gene Roddenberry Planetarium -". Retrieved February 10, 2014. "Lynx Exhibits". Retrieved ...
The vaccine relies on using a virus-like particle that is made of the norovirus capsid proteins in order to mimic the external ... Some people have common variations of the MDA-5 gene that could make them more susceptible to norovirus infection. Viruses in ... 2016) Molecular ecolution of the capsid gene in human norovirus genogroup II. Sci Rep 6:29400 Ozaki K, Matsushima Y, Nagasawa K ... Thorne LG, Goodfellow IG (February 2014). "Norovirus gene expression and replication". The Journal of General Virology. 95 (Pt ...
Order of the British Empire, and Order of the Bath, in Marrickville, New South Wales, Australia (d. 2008) Died: Otto Wagner, ... leading lady to Gene Autry, in Toronto (d. 1991) Died: Karl Ferdinand Braun, German physicist, recipient of the Nobel Prize in ... By evening, a delegation from Musavat met and agreed to sign an ultimatum to order all those involved in the revolt to stand ... The Red Guards general staff ordered all units that could not get over the Russian border to retreat to Vyborg. Battle of ...
Maddaus, Gene (April 6, 2022). "Disney vs. Ron DeSantis: Why the Media Giant's Fight Over 'Don't Say Gay' Keeps Escalating". ... 13-14 In order to receive the commission, Blue Sky spent two days rendering a single frame and submitted it to the prospective ... It was founded on February 22, 1987 by Chris Wedge, Michael Ferraro, Carl Ludwig, Alison Brown, David Brown, and Eugene ... Wedge met Eugene Troubetzkoy, who held a Ph.D in theoretical physics and was one of the first computer animators. Using his ...
Find out whether you can order multiple variable regions in gBlocks Gene Fragment. ... Can I order multiple variable regions in my gBlocks™ Gene Fragment? Currently, only consecutive bases are allowed when ordering ... Specifically, up to 18 consecutive N or K bases can be ordered, with a minimum of 125 bp of fixed, flanking sequence on either ... If you require a sequence outside of these design specifications, please contact for evaluation. ...
Share Client Note: Krogers Long-Lasting Avocados, Anonymous Gene Sequencing, Amazons EV Truck Order, And More on Facebook ... Share Client Note: Krogers Long-Lasting Avocados, Anonymous Gene Sequencing, Amazons EV Truck Order, And More on Twitter ... Share Client Note: Krogers Long-Lasting Avocados, Anonymous Gene Sequencing, Amazons EV Truck Order, And More on LinkedIn ... Share Client Note: Krogers Long-Lasting Avocados, Anonymous Gene Sequencing, Amazons EV Truck Order, And More via Email ...
Nathan Connolly "The Strange Order of Things" June 2, 2023 0 There is a fine Americana undercurrent going through the mainly ... Video: Gene Clark & Carla Olsen "Gypsy Rider". Video: Gene Clark & Carla Olsen "Gypsy Rider". October 6, 2017 Jeremy Searle ... This weeks retro slot features the late great Gene Clark accompanied by Carla Olsen on a wonderful song from his last album So ... June 2, 2023 ] Nathan Connolly "The Strange Order of Things" Album Reviews ...
Genes (Basel) ; 14(7)2023 07 01. Artigo em Inglês , MEDLINE , ID: mdl-37510292 ... Here, we introduce and define squamates (Order Squamata) and review the history and promise of genomic investigations into the ... The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order ...
Cautious Optimism for President Bushs ID Theft Executive Order. *By Gene J. Koprowski ... President Bush this week created an "ID theft prevention" task force by executive order, and Internet security executives are ... Google Taking Pre-Orders for Its First Foldable Phone. May 17, 2023 ...
Order cDNA clone Order cDNA clone. * BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target ... Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side ... Gene Ontology Provided by MGI Function. Evidence Code. Pubs. enables actin binding IEA Inferred from Electronic Annotation. ... GeneRIFs: Gene References Into Functions Whats a GeneRIF? * Fhod1 appears to be dispensable for normal development and ...
... differences between the normal and acidosis rumen epithelial tissues were first examined using the RNA-seq data in order to ... These genes were further clustered in 50 gene ontology (GO) functional terms and 66 Kyoto Encyclopedia of Genes and Genomes ( ... This Special Issue "Farm Animal Genes" invites your manuscripts that discuss the function of genes in any kind of livestock ... To assign the function of genes before the genomic era, the target genes were individually explored through molecular ...
These findings suggest that the ,i,AFF3,/i, gene (rs10865035) has no significant role in the onset of RA in the Pakistani ... Different genome-wide association and candidate gene studies have shown the role of several genetic variants in multiple loci/ ... gene with the genetic background of rheumatoid arthritis (RA) in the Pakistani cohort. A total of 703 individuals, including ... genes with ethnical and geographical variations. This study was designed to detect the association of a single-nucleotide ...
Dr KildareRichard Chamberlain with his 1963Chevrolet Corvette1964 © 1978 Gene Trindl ... Dr Kildare Richard Chamberlain with his 1963 Chevrolet Corvette 1964 © 1978 Gene Trindl. Share this image Order Print License ... Print Order Notes. Please, add any notes related to the print order, like: size of the image, or any other consideration you ... Order Print. Cancel License Image:. Please fill out the form below and we will follow up with you shortly with pricing ...
A post shared by Gene and Georgetti (@gene_georgetti) on Apr 19, 2020 at 11:58am PDT. ... A post shared by Gene and Georgetti (@gene_georgetti) on Apr 19, 2020 at 11:58am PDT. ... Gene & Georgetti. 500 N Franklin St, Chicago, IL 60654. The iconic Chicago steakhouse closed after a kitchen fire last fall but ... Ordering food from one of the many Chicago restaurants that are still open is the easiest way to enjoy a delicious meal at home ...
guitarist Jimi Bell available for pre-order. What a year! - Check out the Sleaze Roxxs Top Ten Albums of 2022!. ... Gene Simmons says hes heard enough celebrity tributes to Michael Jackson, and wants to hear from the kids who accused the late ... Gene Simmons Talks About Michael Jackson. Posted on July 2, 2009 by Skid in Uncategorized // 0 Comments ...
Chromosome Inversion, Chromosomes, Fungal, Evolution, Molecular, Gene Deletion, Gene Duplication, Gene Order, Genes, Fungal, ... We show that evolution of gene order in the genomes of these two yeast species is driven mainly by gene duplication onto ... Changes in gene order between the genomes of two related yeast species, Saccharomyces cerevisiae and Saccharomyces bayanus var ... Evolution of gene order in the genomes of two related yeast species.. ...
Gene 09/02/2009 Vertex Spheres are the best. I would highly recommend the Vertex Sphere. This contact lens is definitely the ... In order to redeem your Vertex Sphere (Encore Sphere) rebate, follow these 3 easy steps: log on to the rebate center, ... In order to last you for 12 months, youll need 4 box(es). These amounts pertain to a single eye, so to cover both eyes, double ... After your order ships, access the Rebate Center to print your contact lens rebate form(s). The mailing address is on the ...
... is a list of genes, transcripts or proteins ordered according to a phenotypic parameter (as well as for Gene Set Enrichment ... Then, you want to know how well the genes at the top of your ranked genes can be connected to the genes (seed list) that are ... The program also offers the option of defining, a part from the ranked list, seed genes (optional). These seed genes are genes ... If not, the default order will be considered. Optional: If you have decided to include a seed list of genes in your analysis, ...
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The Electric Gene Machine. The world is terrified of genetically modified foods, but Baby, you aint seen nothin yet! Genetic ... Thomas A Easton Books In Order. Organic Future Books In Order. *Sparrowhawk (1990) ... Zach Jenkins Books In Order As an Amazon Associate, receives a small portion of the sales, which doesnt create any ...
Dynamic range, 10 orders of magnitude. Protocols/main application on this instrument. Gene expression analysis, microRNA ... Rotor-Gene Kits will also work on the Rotor-Gene 6000 and Rotor-Gene 3000 PCR cyclers with the cycling conditions specified in ... The Rotor-Gene Q, if used in combination with QIAGEN kits indicated for use with the Rotor-Gene Q instrument, is intended for ... Rotor-Gene Kits do not contain ROX dye since no normalization to a passive reference is required. Also, Rotor-Gene Kits do not ...
A total of 660 patients referred to the genetics clinic, Medical Research Institute, Alexandria were assessed to determine the frequency of genetic disorders and the proportion of autosomal recessive disorders. It was found ...
The material in this project series was likely kept in its original order by the archivist who first processed this fonds. ... Don de Gene Summers/. Gift of Gene Summers. Related units of description: *See also photographs an early model of the New ... Gene Summers (archive creator). Title. Sketches and notes from the period when Gene Summers worked in the Office of Mies van ... Gene Summers (archive creator). Description: Notes on sayings and teachings of Mies van der Rohe and others; small sketch and ...
Gene Polymorphisms in Gingivitis. Written By. Lydie Izakovicova Holla, Kristina Musilova, Jan Vokurka, Pavla Pantuckova, ...
Gene Distance. Distance in Base Pairs from Selected Gene. Chromosome. Ordered by Chromosome Position. ... P2P Network Distance to Selected Gene from Marc Vidal data. E. Wanker Protein-to-Protein. P2P Network Distance to Selected Gene ... Difference in Expression with Selected Gene According to GNF Gene Expression Atlas2. ... Number of Shared Gene Ontology Terms. M. Vidal Protein-to-Protein. ...
Order online today, or start a catering order for your event and share with others! ... Order online today, or start a catering order for your event and share with others! ...
Gene-discuss] Pharmacy for real men!, Piggish G. Gingivitis, 11:56. *[Gene-discuss] Your Abel & Cole Order, Chang Howell, 03:51 ... Messages in reverse chronological order. [Next Period]. *June 30, 2006 *[Gene-discuss] Good health is above wealth, Piqued B. ... Gene-discuss] Re: Software, Biopsy S. Scapegoating, 09:07. *[Gene-discuss] Why should you pay more?, Bromide R. Elastic, 08:16 ... Gene-discuss] my eeauw, Kasia Dumais, 12:00. *[Gene-discuss] What IS 0EM Software And Why D0 You Care?, Kaiden Henderson, 09:45 ...
A dog can show you more honest affection with a flick of his tail than a man can gather through a lifetime of handshakes. Gene ... Re: Gordon Strong, Brewing Better Beer on Amazon pre-order & in WorldCat « Reply #180 on: May 31, 2011, 07:40:03 pm » ... Re: Gordon Strong, Brewing Better Beer on Amazon pre-order & in WorldCat « Reply #181 on: May 31, 2011, 07:49:30 pm » ... Re: Gordon Strong, Brewing Better Beer on Amazon pre-order & in WorldCat « Reply #182 on: June 01, 2011, 07:22:55 am » ...
Please select at least one article in order to proceed.. Ok. FilterHide Filter ... including cell-cycle-related genes, were transcriptionally up-regulated. A cistrome analysis guided by the histone methylation ...
Drop Ship Order FREE Shipping to USA Standard delivery: 7 to 14 days More Shipping Options ... Odum, Eugene P. Format/Binding. Paperback Book Condition. Used - Good Quantity Available. 1. ISBN 10. 0030047714. ISBN 13. ...
Eugene and Lillian Youngs Lehman Series) Hardcover from GuitarsofChina Top Quality Guitar Store,Martin Guitar Distributor ... C. F. Martin and His Guitars, 1796-1873 (H. Eugene and Lillian Youngs Lehman Series) Min.Order Quantity:. One Set. Price:. USD$ ... Home , Products , Martin Guitar , C. F. Martin and His Guitars, 1796-1873 (H. Eugene and Lillian Youngs Lehman Series) ... C. F. Martin and His Guitars, 1796-1873 (H. Eugene and Lillian Youngs Lehman Series) Model Number:. ...
  • After the development of DNA chips whole genomes of species, it has been more effective and feasible to find major candidate genes or loci using the genome-wide association study, even some traits have very low heritabilities. (
  • Different genome-wide association and candidate gene studies have shown the role of several genetic variants in multiple loci/genes with ethnical and geographical variations. (
  • We demonstrated that histone H3 Lys-4 was trimethylated at the promoter regions of many loci, among which only a fraction, including cell-cycle-related genes, were transcriptionally up-regulated. (
  • Here, we introduce and define squamates (Order Squamata) and review the history and promise of genomic investigations into the patterns and processes governing squamate evolution, given recent technological advances in DNA sequencing , genome assembly, and evolutionary analysis . (
  • To assign the function of genes before the genomic era, the target genes were individually explored through molecular biological techniques and populational genetics. (
  • This Special Issue "Farm Animal Genes" invites your manuscripts that discuss the function of genes in any kind of livestock animals using the recent advanced molecular genetic technologies, and/or using the whole genomic and transcriptomic NGS data. (
  • The State of Squamate Genomics: Past, Present, and Future of Genome Research in the Most Speciose Terrestrial Vertebrate Order. (
  • uvarum genome, 35 different synteny breakpoints between neighboring genes and two cases of local gene inversion were characterized in detail. (
  • Shigella strains harboring PMQR genes were identified earlier this year following whole genome sequencing of isolates from a multistate outbreak of multidrug-resistant Shigella flexneri infections predominantly affecting adult men, many of whom identify as men who have sex with men, according to epidemiologic data collected by CDC's Shigella program as part of outbreak response. (
  • The complete collection of gene, which is called genome , is a set of instructions for constructing human being. (
  • It is estimated that the entire human genome consists of 50,000 to 100,00 genes. (
  • Y. enterocolitica bacteria contain the urease gene cluster that enables them to hydrolyze urea, however, though this test may yield positive results, Y. enterocolitica is not the only organism that can perform this process, and further testing would be required in order to rule out the presence of other urease producing bacteria. (
  • Taxonomy of the order Mononegavirales: update 2017. (
  • Evolution of gene order in the genomes of two related yeast species. (
  • Changes in gene order between the genomes of two related yeast species, Saccharomyces cerevisiae and Saccharomyces bayanus var. (
  • We show that evolution of gene order in the genomes of these two yeast species is driven mainly by gene duplication onto different chromosomes followed by differential loss of the repeated copies. (
  • DOI: 10.1006/ young could help clarify AIV epide- species of the order Anura. (
  • Some of these genes have been shown to be conserved across a wide range of species. (
  • Rising fluoroquinolone MIC values among Shigella isolates may be related to the emergence of plasmid-mediated quinolone resistance (PMQR) genes in Shigella species in the United States. (
  • Three strains of C diphtheriae are recognized, in decreasing order of virulence: gravis, intermedius, and mitis. (
  • However, recent data from the Centers for Disease Control and Prevention (CDC) and state and local public health partners show that these strains often have a quinolone resistance gene that may lead to clinically significant reduced susceptibility to fluoroquinolone antibiotics. (
  • The presence of genetic polymorphisms in HLA (human leukocyte antigen) and non-HLA genes contributes about 60% to the pathogenesis of RA. (
  • More recently, after the development of next-generation sequencing (NGS) technology, studies have not only focused on genomes, but also transcriptomes to identify the functional genes for target traits including the conventional economic traits and the brand new issues like disease resistance and immune response. (
  • While the transfer of already existing genes from one cell to another characterized an earlier phase of the field of biotechnology, synthetic biology involves the design, assembly, synthesis, or manufacture of new genomes, biological pathways, devices or organisms not found in nature. (
  • For Appendix B , all personal identifiers were removed from the commentsreceived and placed in chronological order. (
  • We also welcome submissions of prospective novel approaches to identify functional genes. (
  • The first era was the classical genetics where phenotypes of interest among family members are observed to identify segregation patterns of the "functional units" of genes or different forms of gene (alleles) and to lead to understanding of genetic mechanisms of particular phenotypes. (
  • The AFF3 (lymphoid nuclear protein related to the AF4 gene) is located at 2q11.2 position and encodes a protein of 1227 amino acids. (
  • The method detects gene sets (forming a protein-protein interaction subnetwork) that are consistently associated to high or low values in a ranked list of genes. (
  • capsid protein gene sequence. (
  • Specifically, up to 18 consecutive N or K bases can be ordered, with a minimum of 125 bp of fixed, flanking sequence on either side of the variable bases. (
  • If you require a sequence outside of these design specifications, please contact [email protected] for evaluation. (
  • The expression of NF-kappa-B dependent genes was increased in HTE cells transfected with an NF-kappa-B consensus sequence and exposed to lipopolysaccharide for 4 or 16 hours or crocidolite for 16 hours. (
  • This study was designed to detect the association of a single-nucleotide polymorphism (SNP) rs10865035 in the AFF3 gene with the genetic background of rheumatoid arthritis (RA) in the Pakistani cohort. (
  • Genetic heritage of the Old Order Mennonites of southeastern Pennsylvania. (
  • In the nematode Caenorhabditis elegans, genetic studies resulted in the discovery of 15 genes that are essential for the apoptotic program. (
  • The AFF3 gene is not only important in the susceptibility to RA but also is a good candidate in the assessment of the therapeutic response in individuals [ 12 ]. (
  • Preliminary data suggest that all Shigella isolates with ciprofloxacin MICs in this range for which results are available harbor at least one quinolone resistance gene known to confer reduced susceptibility in enteric bacteria. (
  • The input for the Gene Set Network Enrichment Analysis (also known as NetworkMiner) is a list of genes, transcripts or proteins ordered according to a phenotypic parameter (as well as for Gene Set Enrichment Analysis or FatiScan). (
  • This gene is highly expressed in the lymphoid tissue and has been suggested to be involved in its development, while a lower level of expression has been reported in other tissues like the brain and lungs [ 1 , 10 - 12 ]. (
  • Asbestos induces nuclear factor kappa B (NF-kappa B) DNA-binding activity and NF-kappa B-dependent gene expression in tracheal epithelial cells. (
  • The effects of asbestos (1332214) on nuclear-factor-kappa-B (NF- kappa-B) DNA binding activity and NF-kappa-B dependent gene expression were examined. (
  • Transfection studies using the calcium phosphate coprecipitation technique were conducted in order to measure NF- kappa-B dependent gene expression. (
  • The authors conclude that asbestos induces NF-kappa-B DNA binding activity and NF-kappa-B dependent gene expression, both of which may be involved in the development of asbestos induced lung cancers. (
  • If grid execution is on & limit exceeded, number of array tasks for the final assembly step per gene segment. (
  • This gene forms a nuclear factor that binds to DNA through its transcriptional activation domain. (
  • Binding of ferrous iron to the DtxR molecule forms a complex that binds to the tox gene operator and inhibits transcription. (
  • Shigella isolates without a quinolone resistance gene typically have a ciprofloxacin MIC of ≤0.015 μg/mL. (
  • Fluoroquinolone resistance is of particular concern given that data from the National Antimicrobial Resistance Monitoring System indicate that many Shigella isolates with a quinolone resistance gene also are resistant to many other commonly used treatment agents, such as azithromycin, trimethoprim-sulfamethoxazole, amoxicillin-clavulanic acid, and ampicillin. (
  • Plasmid-mediated resistance genes are of particular concern because of their ability to spread between bacteria and their ability to promote chromosomal mutations conferring quinolone resistance, potentially resulting in rapid spread of fluoroquinolone resistance within or between populations of bacteria. (
  • Any patient with a Shigella infection could carry a strain harboring a quinolone resistance gene with a ciprofloxacin MIC of 0.12-1 μg/mL. (
  • We must now sustain these good results in order to spare everyone from suffering from leprosy. (
  • Progress in this branch of synthetic biology has yielded remarkable therapeutic advances in gene therapy well beyond the achievements of conventional drugs and biologic agents. (
  • A second capability of synthetic biology involves the re-design of existing genes, cells or organisms for the purpose of gene therapy. (
  • 2. Re-Design Existing Genes. (
  • PMQR genes have also been identified in sporadic cases of Shigella sonnei . (
  • Gene-discuss] Activate Your Account! (
  • Modification of existing genes in living animal and human cells is enabled by engineered nucleases such as meganucleases, zinc finger nucleases, transcription activator-like effector-based nucleases, and the CRISPR-Cas system. (
  • The identification of traces of anciently duplicated genes, called relics, show that the loss of duplicates is more frequently caused by the accumulation of numerous mutations in one of the two copies than by DNA deletion. (
  • This property of the AFF3 gene has made it a strong candidate for autoimmunity in the human cell [ 13 - 15 ]. (
  • This information is packaged in the form of genes made up of DNA. (
  • If you have decided to include a seed list of genes in your analysis, then browse it. (
  • The genes that code for Shiga toxins are generally carried by bacteriophages, which are viruses that can infect bacteria. (
  • Two alpha subunits connect with two beta subunits, which are produced from the BCKDHB gene, to form a critical piece of the enzyme complex called the E1 component. (
  • Can I order multiple variable regions in my gBlocks™ Gene Fragment? (
  • Messenger RNA (mRNA) levels of c- myc, a gene regulated by NF-kappa-B, were determined via Northern blot analysis. (
  • In addition, local gene inversions also would result from a mechanism of gene duplication, but in an inverted orientation, followed by loss of the original copy. (
  • Order your copy now. (
  • This working paper is prepared with the objective of providing brief accounts of development of human genetics and ELSI implications, and possible areas of debate in order to solicit future strategic directions and actions to be undertaken. (
  • Tell the program whether you submit a list of proteins, transcripts or genes. (
  • The material in this project series was likely kept in its original order by the archivist who first processed this fonds. (
  • More than 80 mutations in the BCKDHA gene have been identified in people with maple syrup urine disease. (
  • In the Old Order Mennonite population, where maple syrup urine disease occurs frequently, the most common mutation replaces the amino acid tyrosine with the amino acid asparagine at position 438 (written as Tyr438Asn or Y438N). (
  • This weeks retro slot features the late great Gene Clark accompanied by Carla Olsen on a wonderful song from his last album So Rebellious A Lover . (