Hair Diseases: Diseases affecting the orderly growth and persistence of hair.Oncogene Proteins v-fos: Transforming proteins coded by fos oncogenes. These proteins have been found in the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses which induce osteogenic sarcomas in mice. The FBJ-MSV v-fos gene encodes a p55-kDa protein and the FBR-MSV v-fos gene encodes a p75-kDa fusion protein.Transcription Factors: Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.Transcription, Genetic: The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.Genes, fos: Retrovirus-associated DNA sequences (fos) originally isolated from the Finkel-Biskis-Jinkins (FBJ-MSV) and Finkel-Biskis-Reilly (FBR-MSV) murine sarcoma viruses. The proto-oncogene protein c-fos codes for a nuclear protein which is involved in growth-related transcriptional control. The insertion of c-fos into FBJ-MSV or FBR-MSV induces osteogenic sarcomas in mice. The human c-fos gene is located at 14q21-31 on the long arm of chromosome 14.Gene Expression Regulation: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.Promoter Regions, Genetic: DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.Sp1 Transcription Factor: Promoter-specific RNA polymerase II transcription factor that binds to the GC box, one of the upstream promoter elements, in mammalian cells. The binding of Sp1 is necessary for the initiation of transcription in the promoters of a variety of cellular and viral GENES.Base Sequence: The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.RNA, Messenger: RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Proto-Oncogene Proteins c-fos: Cellular DNA-binding proteins encoded by the c-fos genes (GENES, FOS). They are involved in growth-related transcriptional control. c-fos combines with c-jun (PROTO-ONCOGENE PROTEINS C-JUN) to form a c-fos/c-jun heterodimer (TRANSCRIPTION FACTOR AP-1) that binds to the TRE (TPA-responsive element) in promoters of certain genes.Transcriptional Activation: Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.DNA-Binding Proteins: Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Trans-Activators: Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Nuclear Proteins: Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Transcription Initiation Site: The first nucleotide of a transcribed DNA sequence where RNA polymerase (DNA-DIRECTED RNA POLYMERASE) begins synthesizing the RNA transcript.Repressor Proteins: Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS. Classical repressor proteins are DNA-binding proteins that are normally bound to the OPERATOR REGION of an operon, or the ENHANCER SEQUENCES of a gene until a signal occurs that causes their release.Transcription Factor AP-1: A multiprotein complex composed of the products of c-jun and c-fos proto-oncogenes. These proteins must dimerize in order to bind to the AP-1 recognition site, also known as the TPA-responsive element (TRE). AP-1 controls both basal and inducible transcription of several genes.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.DNA: A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.RNA Polymerase II: A DNA-dependent RNA polymerase present in bacterial, plant, and animal cells. It functions in the nucleoplasmic structure and transcribes DNA into RNA. It has different requirements for cations and salt than RNA polymerase I and is strongly inhibited by alpha-amanitin. EC 2.7.7.6.Cell Nucleus: Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Signal Transduction: The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.Transfection: The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.HeLa Cells: The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.STAT3 Transcription Factor: A signal transducer and activator of transcription that mediates cellular responses to INTERLEUKIN-6 family members. STAT3 is constitutively activated in a variety of TUMORS and is a major downstream transducer for the CYTOKINE RECEPTOR GP130.Basic Helix-Loop-Helix Transcription Factors: A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.Plasmids: Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.Transcription Factors, TFII: The so-called general transcription factors that bind to RNA POLYMERASE II and that are required to initiate transcription. They include TFIIA; TFIIB; TFIID; TFIIE; TFIIF; TFIIH; TFII-I; and TFIIJ. In vivo they apparently bind in an ordered multi-step process and/or may form a large preinitiation complex called RNA polymerase II holoenzyme.Genes, Reporter: Genes whose expression is easily detectable and therefore used to study promoter activity at many positions in a target genome. In recombinant DNA technology, these genes may be attached to a promoter region of interest.Transcription Factor TFIID: The major sequence-specific DNA-binding component involved in the activation of transcription of RNA POLYMERASE II. It was originally described as a complex of TATA-BOX BINDING PROTEIN and TATA-BINDING PROTEIN ASSOCIATED FACTORS. It is now know that TATA BOX BINDING PROTEIN-LIKE PROTEINS may take the place of TATA-box binding protein in the complex.Cyclic AMP Response Element-Binding Protein: A protein that has been shown to function as a calcium-regulated transcription factor as well as a substrate for depolarization-activated CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASES. This protein functions to integrate both calcium and cAMP signals.Receptors, N-Methyl-D-Aspartate: A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for glycine which must be occupied for the channel to open efficiently and a site within the channel itself to which magnesium ions bind in a voltage-dependent manner. The positive voltage dependence of channel conductance and the high permeability of the conducting channel to calcium ions (as well as to monovalent cations) are important in excitotoxicity and neuronal plasticity.Autocrine Communication: Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.Aspartate Aminotransferases: Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.Ficus: A plant genus of the family MORACEAE. It is the source of the familiar fig fruit and the latex from this tree contains FICAIN.D-Aspartate Oxidase: An FAD-dependent peroxisomal flavoenzyme, this catalyzes the oxidative deamination of D-ASPARTATE to OXALOACETATE and AMMONIA using oxygen as electron acceptor.CREB-Binding Protein: A member of the p300-CBP transcription factor family that was initially identified as a binding partner for CAMP RESPONSE ELEMENT-BINDING PROTEIN. Mutations in CREB-binding protein are associated with RUBINSTEIN-TAYBI SYNDROME.Oligonucleotide Array Sequence Analysis: Hybridization of a nucleic acid sample to a very large set of OLIGONUCLEOTIDE PROBES, which have been attached individually in columns and rows to a solid support, to determine a BASE SEQUENCE, or to detect variations in a gene sequence, GENE EXPRESSION, or for GENE MAPPING.Gene Expression Profiling: The determination of the pattern of genes expressed at the level of GENETIC TRANSCRIPTION, under specific circumstances or in a specific cell.Oligonucleotide Probes: Synthetic or natural oligonucleotides used in hybridization studies in order to identify and study specific nucleic acid fragments, e.g., DNA segments near or within a specific gene locus or gene. The probe hybridizes with a specific mRNA, if present. Conventional techniques used for testing for the hybridization product include dot blot assays, Southern blot assays, and DNA:RNA hybrid-specific antibody tests. Conventional labels for the probe include the radioisotope labels 32P and 125I and the chemical label biotin.Oligonucleotides: Polymers made up of a few (2-20) nucleotides. In molecular genetics, they refer to a short sequence synthesized to match a region where a mutation is known to occur, and then used as a probe (OLIGONUCLEOTIDE PROBES). (Dorland, 28th ed)Interferon-gamma: The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.Fetal Growth Retardation: The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Placental Insufficiency: Failure of the PLACENTA to deliver an adequate supply of nutrients and OXYGEN to the FETUS.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Infant, Newborn: An infant during the first month after birth.Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).Gestational Age: The age of the conceptus, beginning from the time of FERTILIZATION. In clinical obstetrics, the gestational age is often estimated as the time from the last day of the last MENSTRUATION which is about 2 weeks before OVULATION and fertilization.
... is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response ... Phosphorylation of Jun at serines 63 and 73 and threonine 91 and 93 increases transcription of the c-jun target genes. ... Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex ... This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein that is highly similar to the viral ...
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can ... dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have ... Fos-related antigen 2 (FRA2) is a protein that in humans is encoded by the FOSL2 gene. ... Molven A, Houge G, Berger R (November 1996). "Chromosomal assignment of the human gene encoding the Fos-related antigen-2 (FRA2 ...
The Fos gene family consists of 4 members: c-Fos, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can ... FOSL1 has been shown to interact with USF1 (human gene) and C-jun. AP-1 (transcription factor) GRCh38: Ensembl release 89: ... Fos-related antigen 1 (FRA1) is a protein that in humans is encoded by the FOSL1 gene. ... Sinke RJ, Tanigami A, Nakamura Y, Geurts van Kessel A (Oct 1993). "Reverse mapping of the gene encoding the human fos-related ...
Casein kinase II subunit alpha' is an enzyme that in humans is encoded by the CSNK2A2 gene. CSNK2A2 has been shown to interact ... CSNK2A2 has been shown to interact with: Activating transcription factor 2, ATF1, C-Fos, CREB binding protein, CSNK2B, FGF1, ... "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit ... Human CSNK2A1 genome location and CSNK2A1 gene details page in the UCSC Genome Browser. Human CSNK2A2 genome location and ...
... and other genes, such as NFE2, NFE2L1 and NFE2L3, encode basic leucine zipper (bZIP) transcription factors. They share ... is a transcription factor that in humans is encoded by the NFE2L2 gene. Nrf2 is a basic leucine zipper (bZIP) protein that ... Venugopal R, Jaiswal AK (Dec 1996). "Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant ... and synergistically activate transcription". Genes to Cells. 6 (10): 857-68. doi:10.1046/j.1365-2443.2001.00469.x. PMID ...
An auxiliary gene, vif (viral infectivity factor), is also encoded. However, the number and role of auxiliary genes varies by ... The closest AP-1 binding site is bound by the Jun and Fos proteins to activate transcription. A duplicated motif in the visna ... The viral tat gene encodes a 94-amino acid protein. Tat is the most enigmatic of the proteins of the visna virus. Most studies ... The gag gene encodes three final glycoprotein products: the capsid, the nucleocapsid, and the matrix protein which links the ...
... is encoded by the FOSB gene. The FOS gene family consists of four members: FOS, FOSB, FOSL1, and FOSL2. These genes encode ... As a transcription factor, ΔFosB produces this behavioral phenotype by regulating the expression of specific target genes, ... The net result is gene activation and increased CDK5 expression. ... In contrast, ΔFosB binds to the c-fos gene and recruits ... putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes". ...
Ubeda M, Vallejo M, Habener JF (November 1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 ... 1993). "Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11)". Genes Chromosomes ... is a pro-apoptotic transcription factor that is encoded by the DDIT3 gene. DNA damage-inducible transcript 3 has been shown to ... Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex ...
Disruption of the gene encoding rat ribosomal protein S3a, also named v-fos transformation effector protein, in v-fos- ... 1998). "A novel snoRNA (U73) is encoded within the introns of the human and mouse ribosomal protein S3a genes". Gene. 210 (2): ... location and cell-free transcription of the functional gene". Gene. 169 (2): 179-85. doi:10.1016/0378-1119(95)00708-3. PMID ... As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through ...
... encodes a 62 kDa protein, which forms heterodimer with c-jun (part of Jun family of transcription factors), resulting in ... to acetylate histones and facilitate gene activation. This is known to occur on many genes including fosB and c-fos in response ... FactorBook c-Fos Drosophila kayak - The Interactive Fly Human FOS genome location and FOS gene details page in the UCSC Genome ... "Targeted disruption of the c-fos gene demonstrates c-fos-dependent and -independent pathways for gene expression stimulated by ...
By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one ... Because the expression of the transactivator gene can be controlled, transactivation can be used to turn genes on and off. If ... GM-CSF and the transcription factor c-Fos. HTLV infects T-cells and via the increased expression of these stimulatory cytokines ... HIV and HTLV are just two of the many viruses that encode transactivators to enhance viral gene expression. These ...
The c-fos gene produces a transcription factor that is activated in several cancers, and it lacks the ARE elements. c-myc gene ... AREsite-a database for ARE containing genes-has recently been developed with the aim to provide detailed bioinformatic ... are involved in genotoxic response-they accumulate in the cytoplasm in response to UV exposure and stabilize mRNAs that encode ... like the c-fos gene, have dispersed AUUUA motifs within or near U-rich regions. Class II elements, like the GM-CSF gene, have ...
"Entrez Gene: CEBPG CCAAT/enhancer binding protein (C/EBP), gamma". Nishizawa M, Nagata S (1992). "cDNA clones encoding leucine- ... 2006). "CEBPG transcription factor correlates with antioxidant and DNA repair genes in normal bronchial epithelial cells but ... CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Ccaat-enhancer-binding proteins ... CCAAT/enhancer-binding protein gamma is a protein that in humans is encoded by the CEBPG gene. The C/EBP family of ...
... transcription factor of the 22-kD zein gene that encodes a class of storage proteins in the endosperm of maize (Zea Mays) ... AP-1 fos/jun heterodimer that forms a transcription factor Jun-B transcription factor CREB cAMP response element transcription ... An evolutionary study from 2008 revealed that 4 bZIP genes were encoded by the genome of the most recent common ancestor of all ... "The Role of bZIP Transcription Factors in Green Plant Evolution: Adaptive Features Emerging from Four Founder Genes". PLoS ONE ...
Motohashi, H (1998). "A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo". Genes Cells. ... The following genes encode small Maf proteins MAFF (Human), Maff (Mouse), maft renamed maff (Zebrafish) MAFG (Human), Mafg ( ... Kataoka, K (1995). "Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription ... The Nrf1-sMaf heterodimers regulate genes responsible for proteasomal genes and metabolism genes. The Nrf2-sMaf heterodimers ...
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene. MafG is one of ... such as c-Jun and c-Fos. sMafs regulate different target genes depending on their partners. For instance, the p45-NF-E2-sMaf ... MafG gene expression is induced by oxidative stresses, such as hydrogen peroxide and electrophilic compounds. Mouse Mafg gene ... The HUGO Gene Nomenclature Committee-approved gene name of MAFG is "v-maf avian musculoaponeurotic fibrosarcoma oncogene ...
Transcription factor jun-B is a protein that in humans is encoded by the JUNB gene. Transcription factor jun-B is a ... "B-ATF functions as a negative regulator of AP-1 mediated transcription and blocks cellular transformation by Ras and Fos". ... Nomura N, Ide M, Sasamoto S, Matsui M, Date T, Ishizaki R (1990). "Isolation of human cDNA clones of jun-related genes, jun-B ... "Entrez Gene: JUNB jun B proto-oncogene". Hu YF, Li R (Jun 2002). "JunB potentiates function of BRCA1 activation domain 1 (AD1) ...
... required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos ... X-box binding protein 1, also known as XBP1, is a protein which in humans is encoded by the XBP1 gene. The XBP1 gene is located ... The expression of this protein is required for the transcription of a subset of class II major histocompatibility genes. ... Furthermore, XBP1 heterodimerizes with other bZIP transcription factors such as c-fos. XBP1 expression is controlled by the ...
Tyrosine-protein phosphatase non-receptor type 2 is an enzyme that in humans is encoded by the PTPN2 gene. The protein encoded ... "Molecular cloning and expression of a protein-tyrosine phosphatase showing homology with transcription factors Fos and Jun". ... 1993). "Isolation and mapping of human T-cell protein tyrosine phosphatase sequences: localization of genes and pseudogenes ... Three alternatively spliced variants of this gene, which encode isoforms differing at their extreme C-termini, have been ...
B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene. This gene is a proto-oncogene ... "Candidate proto-oncogene bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-kappa B". Nature. 358 (6387): ... BCL3 has been shown to interact with: BARD1, C-Fos, C-jun, C22orf25, COPS5, EP300, HTATIP, NFKB1, NFKB2, PIR, and NR2B1. GRCh38 ... Ohno H, Takimoto G, McKeithan TW (May 1990). "The candidate proto-oncogene bcl-3 is related to genes implicated in cell lineage ...
"Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". ... is a downstream gene target for Tbx genes". J. Biol. Chem. 280 (12): 11816-28. doi:10.1074/jbc.M412408200. PMID 15591049. Li S ... This protein regulates the activity of many immediate early genes, for example c-fos, and thereby participates in cell cycle ... Zhu H, Joliot V, Prywes R (February 1994). "Role of transcription factor TFIIF in serum response factor-activated transcription ...
To produce c-fos, a protein encoded by the Fos gene, Elk1 needs to be phosphorylated by MAPKs at its C-terminus. MAPKs are the ... ETS domain-containing protein Elk-1 is a protein that in humans is encoded by the ELK1 gene. Elk-1 functions as a transcription ... suggesting that the SRE-regulated early genes other than c-fos could be targets of Elk1. egr-1 is an example of an Elk1 target ... Elk1 also inhibits transcription of presenilin 1 (PS1), which encodes a protein that is necessary for the last step of the ...
... is a protein that in humans is encoded by the ATF4 gene. This gene encodes a transcription factor that was originally ... Hai T, Curran T (1991). "Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity ... GRP78/BiP and novel genes". J. Biol. Chem. 271 (47): 29659-65. doi:10.1074/jbc.271.47.29659. PMID 8939898. Reddy TR, Tang H, Li ... The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription ...
... 2 (JUNDM2) is a protein that in humans is encoded by the JDP2 gene. The Jun dimerization protein is a ... and increases DNA-binding activity of the Nrf2-MafK complex to the ARE and the transcription of ARE-dependent genes such as HO1 ... which is located at about 250 kbp in the Fos-JDP2-BATF locus. Alternative splicing of JDP2 generates at least two isoforms. The ... JDP2 is involved in the modulation of gene expression. For example, JDP2 regulates MyoD gene expression with c-Jun and gene for ...
For the genes that encoded intracellular signaling molecules, Zhang et al. focused on the Wrch1 gene. After experimentation ... HDACs are enzymes that can deacetylate the histones associated with genes. This can activate genes for transcription. Several ... Also involved in the CREB-Fos protein pathways is the dopamine D1 receptor (DRD1), expressed in neurons in the nucleus ... Once this connection between transcription factors had been established, the researchers were curious if other genes caused ...
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors ... consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on ... Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7] ... Gene ontology. Molecular function. • transcription factor activity, sequence-specific DNA binding. • RNA polymerase II ...
The SRF gene is highly conserved through evo … ... We have isolated cDNA clones encoding serum response factor ( ... is a sequence required for transient transcriptional activation of genes in response to growth factors. ... The serum response element (SRE) is a sequence required for transient transcriptional activation of genes in response to growth ... Isolation and Properties of cDNA Clones Encoding SRF, a Transcription Factor That Binds to the C-Fos Serum Response Element ...
c-Jun is a protein that in humans is encoded by the JUN gene. c-Jun in combination with c-Fos, forms the AP-1 early response ... Phosphorylation of Jun at serines 63 and 73 and threonine 91 and 93 increases transcription of the c-jun target genes. ... Ubeda M, Vallejo M, Habener JF (1999). "CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex ... This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein that is highly similar to the viral ...
Among the genes shared by HD- and RTX-PC were upregulated genes: transcription factors (JUN, JUNB, FOS), antiapoptotic genes ( ... FOS, JUN, JUNB, RORA); genes related to the unfolded protein response (Dnaj, HSPB1, MAFF, ATF3); and genes encoding adhesion ... 1 cell cycle gene and ≤1 PC genes) or a "PC signature" (no cell cycle gene and ,1 PC genes) or as "unclassified." (D) 3D PCA ... 1 cell cycle gene and ≤1 upregulated PC genes) or a "PC signature" (no cell cycle gene and ,1 upregulated PC genes) or as " ...
Casein kinase II subunit alpha is an enzyme that in humans is encoded by the CSNK2A2 gene. CSNK2A2 has been shown to interact ... CSNK2A2 has been shown to interact with: Activating transcription factor 2, ATF1, C-Fos, CREB binding protein, CSNK2B, FGF1, ... "Mapping of the human casein kinase II catalytic subunit genes: two loci carrying the homologous sequences for the alpha subunit ... Human CSNK2A1 genome location and CSNK2A1 gene details page in the UCSC Genome Browser. Human CSNK2A2 genome location and ...
Because fosB gene products function as transcription factors, it will be important to identify the specific target genes that ... Putative target genes, which warrant further study, include those that encode certain intracellular messenger proteins, ... Thus, fosB gene products are not required for essentially normal development of the striatum. Rather, the absence of fosB gene ... are products of the fosB gene, presumably ΔFosB variants and FosB, respectively, and that fosB gene products predominate, among ...
... on levels of mRNAs encoding the endogenous CRE-containing genes, c-fos and BDNF (exons I and IV). Ca2+- and cAMP-dependent BDNF ... cAMP can stimulate the transcription of many activity-dependent genes via activation of the transcription factor, cAMP response ... After reverse transcription, levels of c-fos, and exons I and IV of BDNF were determined by quantitative real-time PCR. Data ... Stimulation of CREB-dependent gene transcription requires activation of NR2B-containing NMDARs and L-type Cavs. a, b, Induction ...
AP-1 Transcription Factor Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - ... Complete information for FOSB gene (Protein Coding), FosB Proto-Oncogene, ... Entrez Gene Summary for FOSB Gene. * The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode ... Domains & Families for FOSB Gene Gene Families for FOSB Gene. HGNC:. *1256 : Fos transcription factor family ...
These include a gene encoding a clathrin-like protein, PKR (discussed below), HIF-1α, and the fos family member, Fra-1. HIF-1α ... Previous studies involving Northern blot and nuclear run-on analyses determined that PKR gene transcription in Daudi cells ... The genes associated with intensities greater than 1,000 (≈300 genes) include many of the ribosomal genes and commonly known, ... genes induced by all three types of IFNs, (ii) genes induced by IFN-α or IFN-β, (iii) genes preferentially induced by IFN-β, ...
"Isolation and properties of cDNA clones encoding SRF, a transcription factor that binds to the c-fos serum response element". ... in the promoter region of target genes. This protein regulates the activity of many immediate early genes, for example c-fos, ... Gene transcriptions · General transcription factor · General transcription factor II As · General transcription factor II Bs · ... General transcription factor II Fs/Quiz · General transcription factor II Hs/Quiz · Gene transcriptions/Quiz · GLM boxes/Quiz · ...
RsMADS genes were located in nine linkage groups of radish from R1 to R9. Moreover, the homologous MADS-box gene pairs were ... RsMADS genes were located in nine linkage groups of radish from R1 to R9. Moreover, the homologous MADS-box gene pairs were ... These results could provide a valuable resource to explore the potential functions of RsMADS genes in radish, and facilitate ... These results could provide a valuable resource to explore the potential functions of RsMADS genes in radish, and facilitate ...
Neurogenin 1, a transcription factor that governs the progression of neurogenesis. *FOS like 1, implicated in development of ... Gene ontology testing further narrowed the list to five candidate genes that are essential for normal neurodevelopment and for ... Mitogen-activated protein kinase 8 interacting protein 2, encodes a scaffolding protein broadly expressed in the brain. ... Enigmatic gene critical for a healthy brain. April 16, 2018 New research has shown how an unusual gene is needed for brain ...
... and change in c-fos transcription (observed in F1 and F2). Transcription of the gene encoding DNA methyltransferase (dnmt3ba) ... Genes involved in the intracellular signaling together with candidate genes were included for gene expression analysis. ... To explore how cAMP regulated switching, we investigated the transcription of the MTS1 gene, encoding an inducer of switching. ... In addition, strains lacking the MSN2 gene, which encodes a transcription factor that binds the stress response element (STRE ...
3 reverse transcription control and 3 positive PCR quality controls. Comparison of the gene expression profile of the 84 genes ... Fbp1 encodes fructose-1,6-bisphosphatase, a key enzyme in the regulation of gluconeogenesis.56 Gck encodes glucokinase ... and transcription factors, such as Cebpb, Fos, Jun, Pparg and Srebf1 (unpublished results, Table 2). Our study was limited at ... Gpd1, Hk2 and Pklr encode for glycolytic enzymes. Gpd1 encodes glycerol-3-phosphate dehydrogenase 1 that has an important role ...
... of the known ABI genes. Products of three of these genes, ABI3, ABI4, and ABI5 itself, are presumed to be transcription factors ... 1994). Isolation and characterization of a fourth Arabidopsis thaliana G-box-binding factor, which has similarities to Fos ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor. Ruth R. Finkelstein, Tim ... The Arabidopsis Abscisic Acid Response Gene ABI5 Encodes a Basic Leucine Zipper Transcription Factor ...
FOS Like 2, AP-1 Transcription Factor Subunit, including: function, proteins, disorders, pathways, orthologs, and expression. ... The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can ... Entrez Gene Summary for FOSL2 Gene. * The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes ... GeneCards Summary for FOSL2 Gene FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Among its ...
Transcription factor encoded by fos is stabilized by ERK and continues to affect other IE genes such as jun ... For each gene, define the adjusted "t-statistic" as follows:. Objective: The replicated expression for each gene is taken for ... a. Calculate gene expression metric, x:. *For each gene i on a given chip j: xij ={rMedianIntensity (treated) / ... with genes showing ,= 2 fold change in at least one condition while keeping ligands in alphabetical/time course order:. Average ...
Accordingly, context-associative learning induces differential CRTC1-dependent transcription of c-fos and the nuclear receptor ... Genes & Expression*BioSystems. *Database of Genotypes and Phenotypes (dbGaP). *E-Utilities. *Gene ... CRTC1 Function During Memory Encoding Is Disrupted in Neurodegeneration.. Parra-Damas A1, Chen M1, Enriquez-Barreto L1, Ortega ... Importantly, CRTC1 gene therapy in the hippocampus ameliorates context memory and transcriptional deficits and dendritic ...
Microarray gene expression studies indicated that patterns of over two hundred genes encoding transcription factors, nuclear ... Expression of known adipocyte genes included GATA3, RARA, RXRG, c-Fos, STAT5B and conventional transcription factors. ... Expression at the gene and protein level of these and several major adipogenic factors (except for HSL and LPL) is precocious ... and thyroid hormones represent the critical aspect of endocrine regulation of fetal adipocyte number and size and leptin gene ...
1991) Regulation of a fos-lacZ fusion gene: a paradigm for quantitative analysis of stimulus-transcription coupling. Proc Natl ... Expression ofc-fos and the cell adhesion molecule L1 genes is regulated by single action potential stimulation delivered at 10 ... Calcium signaling and c-fos expression. The concentration dynamics of intracellular Ca2+ might encode differences in action ... 1983) Analysis of FBJ-MuSv provirus and c-fos (mouse) gene reveals that viral and cellular fos gene products have different ...
... which include c-Fos, FosB, Fra1, and Fra2. All Fos family proteins heterodimerize... ... FosB short form ΔFosB is encoded by the FosBgene and shares homology with other Fos family transcription factors, ... ΔFosB is encoded by the FosB gene and shares homology with other Fos family transcription factors, which include c-Fos, FosB, ... present in the promoters of certain genes to regulate their transcription. The genes encoding Fos family proteins are termed ...
ΔFosB is encoded by the fosB gene (figure 1) and shares homology with other Fos family transcription factors, which include c- ... Several target genes of ΔFosB have been established using a candidate gene approach (table 3). One candidate gene is GluR2, an ... 2007). By contrast, cocaine represses the c-fos gene: when ΔFosB binds to this gene it recruits an HDAC and possibly histone ... present in the promoters of certain genes to regulate their transcription. These Fos family proteins are induced rapidly and ...
Examples of such transcription factors are members of the jun, fos, myc, NFkB and STAT gene families. In cancer cells this ... Most oncogenes encode activators of transcription factors or transcription factors themselves. Transcription factors that are ... in contrast to transcription factors that regulate house keeping genes, tightly regulated and only active, when a stimulus (e.g ... Most oncogenes encode activators of transcription factors or transcription factors themselves. Transcription factors that are ...
A few selected genes in this group are shown in Fig. 5H. The stanniocalcin gene, for example (Fig. 5H), encodes a secreted ... The immediate response to serum stimulation was dominated by genes that encode transcription factors and other proteins ... The mRNAs for several genes [including c-FOS, JUN B, and mitogen-activated protein (MAP) kinase phosphatase-1 (MKP1)] were ... genes encoding proteins involved in intercellular signaling (Fig. 5). Genes induced in this program encode products that can (i ...
FOSL1, another weakly down-regulated gene in treated stem cells, encodes for Fra-1, a component of the dimeric transcription ... Allogro® also modulates the expression of genes encoding for collagenic extracellular matrix proteins like collagen type 1α1 ( ... differential expression of Fos and Jun family members could play a role in the developmental regulation of bone-specific gene ... Reverse transcription to cDNA was performed directly from cultured cell lysate using the TaqMAn Gene Expressio Cells-to-Ct Kit ...
Work on oncogenes such as myc and fos, which encode mRNAs that are short lived in untransformed cells, demonstrated that these ... The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules. Nat. Immunol. 10 ... In addition to regulation at the level of gene transcription, regulating RNA stability offers the potential to control mRNA ... the identification of promoters and enhancers that regulate gene transcription in tissue-specific and inducible manners). ...
  • Germline (inherited) mutations in either the BRCA1 or BRCA2 gene confer an increased risk of breast and/or ovarian cancer to women. (massgeneral.org)
  • Neue Bilder guiding to cultured genes, in the viral download τέσσερα the anion) diarrhea binds associated from only 200 alpha Archivists to also 80 mutations by the PAN2-PAN3 guidance. (familie-vos.de)
  • As there is also a gene encoding a mitochondrial form of this enzyme, mutations in either gene may contribute to these disorders. (genecards.org)
  • Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. (genecards.org)
  • Mutations in this gene cause Aicardi-Goutieres Syndrome (AGS), a an autosomal recessive neurological disorder characterized by progressive microcephaly and psychomotor retardation, intracranial calcifications, elevated levels of interferon-alpha and white blood cells in the cerebrospinal fluid. (genecards.org)
  • Mutations in this gene cause cystathioninuria. (genecards.org)
  • Mutations within this gene have been associated with polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also known as Nasu-Hakola disease. (genecards.org)
  • Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associat. (genecards.org)
  • Mutations in genes such as hemipterous ( hep ) and basket ( bsk , also known as DJNK ) result in abnormal embryos with a dorsal hole or abnormal adults with a dorsal midline cleft ( 1 , 2 ). (sciencemag.org)
  • Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. (genecards.org)
  • 11553624 ). Phosphorylates ETV1/ER81 at 'Ser-191' and 'Ser-216', and thereby regulates its ability to stimulate transcription, which may be important during development and breast tumor formation (By similarity). (uniprot.org)
  • Usually multiple oncogenes , along with mutated apoptotic or tumor suppressor genes will all act in concert to cause cancer. (lookformedical.com)
  • High expressions of KYNU can block the anti-tumor effects of chimeric antigen receptor T-cell therapy, indicating complex interactions between the co-expressed genes. (ashpublications.org)
  • The product of the APC tumor suppressor gene has been observed to interact with β-catenin and has thus been proposed to regulate cellular signaling events ( 1 ). (sciencemag.org)
  • 2009) Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration‐resistant prostate cancer. (els.net)
  • In Arabidopsis thaliana , cis -regulatory sequences of the floral homeotic gene AGAMOUS ( AG ) are located in the second intron. (plantcell.org)
  • Using reporter gene analyses, we tested six of these motifs and found that they are all functionally important for the activity of AG regulatory sequences in A. thaliana . (plantcell.org)
  • Architecture of the human regulatory network derived from ENCODE data Nature. (usc.edu)
  • The convergence of Hox function and Dpp signaling therefore occurs at the levels of DNA and transcription, and endows AbdA with PS8-specific regulatory properties. (biologists.org)
  • Despite close structural similarity with the standard H3.1 and H3.2, histone H3.3 has an extraordinary property in that it is incorporated into nucleosomes and DNA only in actively transcribed genes. (nih.gov)
  • Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A (By similarity). (uniprot.org)
  • FAM225B (Family With Sequence Similarity 225 Member B) is an RNA Gene, and is affiliated with the lncRNA class. (genecards.org)
  • The ability of Usf-1 to activate transcription is regulated by a signal transduction pathway that culminates in phosphorylation and activation of Usf-1 by the p38 stress-activated kinase. (wikiversity.org)
  • The todS gene is predicted to encode a sensory hybrid kinase with two unique properties-a basic region leucine zipper dimerization motif at the N terminus and a duplicated histidine kinase motif. (canada.ca)
  • Src (pronounced "sarc" as it is short for sarcoma ) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. Michael Bishop and Harold E. Varmus, for which they were awarded the 1989 Nobel Prize in Physiology or Medicine. (lookformedical.com)
  • The P-element was inserted in the 5′ untranslated region (UTR) of the Src42A gene, which encodes a Src-family nonreceptor tyrosine kinase ( 4-6 ). (sciencemag.org)
  • Using conditionally immortalized podocytes after differentiation, we found that infection of podocytes with nef increased Src kinase activity and signal transducer and activator of transcription 3 (Stat3) phosphorylation and activated the Ras-c-Raf-MAPK1,2 pathway. (jci.org)
  • Previously, we identified Drosophila slipper ( slpr ), encoding a m ixed l ineage k inase (MLK), as an upstream kinase stimulating the JNK pathway controlling the morphogenetic process of dorsal closure. (genetics.org)
  • There play two groups of chain: non-crossover( NCO) and housing( CO). Negative conjugation has encoded by membrane sites named by SPO11, which is Typically mediated to the 5' proteins after neurotransmitter. (erik-mill.de)
  • The biogenesis of cellular organelles involves the assembly and targeting of numerous proteins and membrane lipids, and often these processes are orchestrated by transcription factors whose activities are adjusted in response to stress or developmental cues. (biomedcentral.com)
  • Furthermore, the identification of oncogenes involved in cisplatin resistance has already led to in vitro approaches which successfully inactivated these genes using ribozymes or antisense oligodeoxynucleotides, thus restoring cisplatin sensitivity. (nih.gov)
  • We are also interested in histone H3.3, the variant histone that is selectively associated with actively expressed genes. (nih.gov)
  • Although there is mounting recognition of the importance of transcription-coupled histone incorporation, the process and its physiological significance are still shrouded in mystery. (nih.gov)
  • dCas9-based epigenome editing suggests acquisition of histone methylation is not sufficient for target gene repression Nucleic Acids Res. (usc.edu)
  • The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. (genecards.org)
  • This gene encodes a cytoplasmic enzyme in the trans-sulfuration pathway that converts cystathione derived from methionine into cysteine. (genecards.org)
  • slipper ( slpr ), which encodes the Drosophila homolog of mammalian MLKs, has previously been implicated in activation of the JNK pathway during embryonic dorsal epidermal closure. (genetics.org)
  • Consequently, CD44ICD acts as a signal transduction molecule, where it translocates to the nucleus and activates transcription mediated through the 12- O -tetradecanoylphorbol 13-acetate-responsive element, which is found in numerous genes involved in diverse cellular processes. (rupress.org)
  • Gene Ontology (GO) annotations related to this gene include electron transfer activity and cytochrome-c oxidase activity . (genecards.org)
  • A reporter gene is a gene whose product can be readily detected and either fused to the gene of interest or cloned instead of that particular gene. (frontiersin.org)
  • Nuclei of APC −/− colon carcinoma cells were found to contain a stable β-catenin-hTcf-4 complex that was constitutively active, as measured by transcription of a Tcf reporter gene. (sciencemag.org)
  • The present microarray analysis demonstrates that primary murine hepatocytes responded to IL-17 stimulation by upregulation of chemokines and genes, which are functionally responsible to increase and sustain inflammation. (biomedcentral.com)
  • As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. (fishersci.com)
  • We discuss evidence for its involvement in the encoding of experience to long-term memory across time and biological levels of organization ranging from individual cells to cell ensembles and whole organisms. (pnas.org)
  • If normal genes promoting cellular growth, through mutation , are up-regulated, (gain of function mutation ) they will predispose the cell to cancer and are thus termed oncogenes . (lookformedical.com)
  • The POMC gene is transcriptionally regulated by a variety of hormones and neuropeptides and the second messengers cAMP and Ca ++ . Using the corticotrope-derived AtT20 cell line, we have previously shown that overexpression of cFos stimulates POMC transcription. (elsevier.com)
  • The colorectal cavity of packaging of genes and acids of the cell are specification of tropocollagens of proteasome-mediated BMPs. (familie-vos.de)
  • A few evolutionarily conserved molecules, including Hox selector genes and signaling molecules, play fundamental roles in these processes, which raises the question of how a restricted number of molecules instruct the cell fate complexity of developing animals. (biologists.org)
  • The world B12 is abundantly activated for signal, since target derivatives in mediated transcription acids of TFB1M was that it is iron in fibrin all of S-adenosylmethionine diameter and muscle turbine worker. (evakoch.com)