Schistosoma mansoni: A species of trematode blood flukes of the family Schistosomatidae. It is common in the Nile delta. The intermediate host is the planorbid snail. This parasite causes schistosomiasis mansoni and intestinal bilharziasis.Genome, Helminth: The genetic complement of a helminth (HELMINTHS) as represented in its DNA.DNA, Helminth: Deoxyribonucleic acid that makes up the genetic material of helminths.Biomphalaria: A genus of planorbid freshwater snails, species of which are intermediate hosts of Schistosoma mansoni.Schistosoma japonicum: A species of trematode blood flukes belonging to the family Schistosomatidae whose distribution is confined to areas of the Far East. The intermediate host is a snail. It occurs in man and other mammals.Helminth Proteins: Proteins found in any species of helminth.Schistosoma: A genus of trematode flukes belonging to the family Schistosomatidae. There are over a dozen species. These parasites are found in man and other mammals. Snails are the intermediate hosts.Schistosoma haematobium: A species of trematode blood flukes of the family Schistosomatidae which occurs at different stages in development in veins of the pulmonary and hepatic system and finally the bladder lumen. This parasite causes urinary schistosomiasis.Schistosomiasis mansoni: Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Schistosomatidae: A family of blood flukes of the class Trematoda which is found in animals and man. It Includes the genera Heterobilharzia, Schistosomatium, Schistosoma, Ornithobilharzia, Bilharziella, Trichobilharzia, Pseudobilharzia, and Austrobilharzia.Schistosomiasis: Infection with flukes (trematodes) of the genus SCHISTOSOMA. Three species produce the most frequent clinical diseases: SCHISTOSOMA HAEMATOBIUM (endemic in Africa and the Middle East), SCHISTOSOMA MANSONI (in Egypt, northern and southern Africa, some West Indies islands, northern 2/3 of South America), and SCHISTOSOMA JAPONICUM (in Japan, China, the Philippines, Celebes, Thailand, Laos). S. mansoni is often seen in Puerto Ricans living in the United States.Snails: Marine, freshwater, or terrestrial mollusks of the class Gastropoda. Most have an enclosing spiral shell, and several genera harbor parasites pathogenic to man.Trematoda: Class of parasitic flukes consisting of three subclasses, Monogenea, Aspidogastrea, and Digenea. The digenetic trematodes are the only ones found in man. They are endoparasites and require two hosts to complete their life cycle.Trematode Infections: Infections caused by infestation with worms of the class Trematoda.Schistosomiasis japonica: Schistosomiasis caused by Schistosoma japonicum. It is endemic in the Far East and affects the bowel, liver, and spleen.Fasciola hepatica: A species of helminth commonly called the sheep liver fluke. It occurs in the biliary passages, liver, and gallbladder during various stages of development. Snails and aquatic vegetation are the intermediate hosts. Occasionally seen in man, it is most common in sheep and cattle.Opisthorchis: A genus of trematode liver flukes of the family Opisthorchidae. It consists of the following species: O. felineus, O. noverca (Amphimerus noverca), and O. viverrini. The intermediate hosts are snails, fish, and AMPHIBIANS.Praziquantel: An anthelmintic used in most schistosome and many cestode infestations.Parasite Egg Count: Determination of parasite eggs in feces.Antigens, Helminth: Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.Host-Parasite Interactions: The relationship between an invertebrate and another organism (the host), one of which lives at the expense of the other. Traditionally excluded from definition of parasites are pathogenic BACTERIA; FUNGI; VIRUSES; and PLANTS; though they may live parasitically.Schistosomiasis haematobia: A human disease caused by the infection of parasitic worms SCHISTOSOMA HAEMATOBIUM. It is endemic in AFRICA and parts of the MIDDLE EAST. Tissue damages most often occur in the URINARY TRACT, specifically the URINARY BLADDER.Life Cycle Stages: The continuous sequence of changes undergone by living organisms during the post-embryonic developmental process, such as metamorphosis in insects and amphibians. This includes the developmental stages of apicomplexans such as the malarial parasite, PLASMODIUM FALCIPARUM.Fascioliasis: Liver disease caused by infections with parasitic flukes of the genus FASCIOLA, such as FASCIOLA HEPATICA.Opisthorchiasis: Infection with flukes of the genus Opisthorchis.Antibodies, Helminth: Immunoglobulins produced in a response to HELMINTH ANTIGENS.Disease Vectors: Invertebrates or non-human vertebrates which transmit infective organisms from one host to another.Anthelmintics: Agents destructive to parasitic worms. They are used therapeutically in the treatment of HELMINTHIASIS in man and animal.Heterophyidae: A family of intestinal flukes of the class Trematoda which occurs in animals and man. Some of the genera are Heterophyes, Metagonimus, Cryptocotyle, Stellantchasmus, and Euryhelmis.Fasciola: A genus of trematode liver flukes of the family Fasciolidae. Two species of this genus are F. hepatica and F. gigantica. The parasites are found in the liver and gallbladder and associated ducts in mammals and occasionally man. F. gigantica occurs rarely in man.Retroelements: Elements that are transcribed into RNA, reverse-transcribed into DNA and then inserted into a new site in the genome. Long terminal repeats (LTRs) similar to those from retroviruses are contained in retrotransposons and retrovirus-like elements. Retroposons, such as LONG INTERSPERSED NUCLEOTIDE ELEMENTS and SHORT INTERSPERSED NUCLEOTIDE ELEMENTS do not contain LTRs.Metacercariae: Encysted cercaria which house the intermediate stages of trematode parasites in tissues of an intermediate host.Oxamniquine: An anthelmintic with schistosomicidal activity against Schistosoma mansoni, but not against other Schistosoma spp. Oxamniquine causes worms to shift from the mesenteric veins to the liver where the male worms are retained; the female worms return to the mesentery, but can no longer release eggs. (From Martindale, The Extra Pharmacopoeia, 31st ed, p121)Liver Diseases, Parasitic: Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).Dicrocoelium: A genus of trematode liver flukes of the family Dicrocoeliidae which includes the species dendriticum and hospes. It occurs in the biliary passages or liver of many vertebrates including man. The intermediate hosts are mainly mollusks but occasionally ants.Echinostoma: A genus of intestinal flukes of the family Echinostomatidae which consists of many species. They occur in man and other vertebrates. The intermediate hosts are frequently mollusks.Cercaria: The free-swimming larval forms of parasites found in an intermediate host.Phylogeny: The relationships of groups of organisms as reflected by their genetic makeup.Lung Diseases, Parasitic: Infections of the lungs with parasites, most commonly by parasitic worms (HELMINTHS).Bulinus: A genus of small freshwater snails of the order Pulmonata, found throughout Africa and the Middle East, where it is a vector of SCHISTOSOMA HAEMATOBIUM.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Clonorchiasis: Infection of the biliary passages with CLONORCHIS SINENSIS, also called Opisthorchis sinensis. It may lead to inflammation of the biliary tract, proliferation of biliary epithelium, progressive portal fibrosis, and sometimes bile duct carcinoma. Extension to the liver may lead to fatty changes and cirrhosis. (From Dorland, 27th ed)Granuloma: A relatively small nodular inflammatory lesion containing grouped mononuclear phagocytes, caused by infectious and noninfectious agents.Paragonimus: A genus of lung flukes of the family Troglotrematidae infecting humans and animals. This genus consists of several species one of which is PARAGONIMUS WESTERMANI, a common lung fluke in humans.Echinostomiasis: Infection by flukes of the genus Echinostoma.Paragonimiasis: Infection with TREMATODA of the genus PARAGONIMUS.Ovum: A mature haploid female germ cell extruded from the OVARY at OVULATION.Trophoblasts: Cells lining the outside of the BLASTOCYST. After binding to the ENDOMETRIUM, trophoblasts develop into two distinct layers, an inner layer of mononuclear cytotrophoblasts and an outer layer of continuous multinuclear cytoplasm, the syncytiotrophoblasts, which form the early fetal-maternal interface (PLACENTA).Chorionic Villi: The threadlike, vascular projections of the chorion. Chorionic villi may be free or embedded within the DECIDUA forming the site for exchange of substances between fetal and maternal blood (PLACENTA).Placenta: A highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products. It includes a fetal portion (CHORIONIC VILLI) derived from TROPHOBLASTS and a maternal portion (DECIDUA) derived from the uterine ENDOMETRIUM. The placenta produces an array of steroid, protein and peptide hormones (PLACENTAL HORMONES).HLA-G Antigens: Class I human histocompatibility (HLA) surface antigens encoded by alleles on locus B of the HLA complex. The HLA-G antigens are considered non-classical class I antigens due to their distinct tissue distribution which differs from HLA-A; HLA-B; and HLA-C antigens. Note that several isoforms of HLA-G antigens result from alternative splicing of messenger RNAs produced from the HLA-G*01 allele.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.Placentation: The development of the PLACENTA, a highly vascularized mammalian fetal-maternal organ and major site of transport of oxygen, nutrients, and fetal waste products between mother and FETUS. The process begins at FERTILIZATION, through the development of CYTOTROPHOBLASTS and SYNCYTIOTROPHOBLASTS, the formation of CHORIONIC VILLI, to the progressive increase in BLOOD VESSELS to support the growing fetus.Tissue Plasminogen Activator: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
... and the blood fluke Schistosoma japonicum. In some of these species the presence of miR-10 has been shown experimentally, in ... The mir-10 genes are found within the Hox gene clusters. In mammals there are four Hox gene clusters, these contain five genes ... The miR-10 microRNA precursor is a short non-coding RNA gene involved in gene regulation. It is part of an RNA gene family ... It also acts synergistically with HoxB4 to repress these genes. The mir-10 gene is located near to the HoxB1a and HoxB3a genes ...
... is a genus of trematodes, commonly known as blood-flukes. They are parasitic flatworms responsible for a highly ... genes shows phylogenic relations of species in the genus Schistosoma: Schistosoma japonicum Schistosoma haematobium Schistosoma ... The four species are Schistosoma bomfordi Schistosoma datta Schistosoma harinasutai Schistosoma turkestanicum The hybrid S. ... "A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni". PLoS Neglected ...
... is a water-borne parasite of humans, and belongs to the group of blood flukes (Schistosoma). The adult ... Portease included the invadolysin (host penetration) and cathepsin (blood-feeding) gene families. In 2012, an improved version ... July 2009). "The genome of the blood fluke Schistosoma mansoni". Nature. 460 (7253): 352-8. doi:10.1038/nature08160. PMC ... January 2012). "A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni". ...
The best studied group, the blood flukes of the genus Schistosoma, infect and cause disease in humans. Other genera which are ... The phylogeny of the Schistosomatidae based on three genes with emphasis on the interrelationships of Schistosoma Weinland, ... There are a number of different families of blood fluke including the Schistosomatidae. The others include the spirorchiids ( ... Schistosomatidae differ from other blood flukes in having separate sexes and homeothermic hosts. They have compensated for the ...
January 2012). "A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni". ... July 2007). "Sea anemone genome reveals ancestral eumetazoan gene repertoire and genomic organization". Science. 317 (5834): 86 ... 2009). "The genome of the blood fluke Schistosoma mansoni". Nature. 460 (7253): 352-358. Bibcode:2009Natur.460..352B. doi: ... Schistosoma japonicum, schistosome (human pathogen) (2009) Schistosoma mansoni, schistosome (human pathogen) (2009, 2012) ...
"The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao- ... The Pol gene produces three proteins: a protease (PR), a reverse-transcriptase endowed with an RT (reverse-transcriptase) and ... doi:10.1016/j.gene.2006.08.007. PMID 17052864. Neumann, P; Pozárková, D; Macas, J (October 2003). "Highly abundant pea LTR ... The Gag and Pol genes are encoded in the same mRNA. Depending on the host species, two different strategies can be used to ...
... the human blood flukes, which are the second-most prevalent parasitic infections, after malaria. Artemisinin and its ... The parasite's kelch gene on chromosome 13 appears to be a reliable molecular marker for clinical resistance in southeast Asia ... including Schistosoma japonicum, S. mansoni, S. haematobium, Clonorchis sinensis, Fasciola hepatica, and Opisthorchis viverrini ... Mild blood abnormalities have also been noted. A rare but serious adverse effect is allergic reaction. One case of significant ...
figure 3. Bartsch P. (1936). "Molluscan intermediate hosts of the Asiatic blood fluke, Schistosoma japonicum, and species ... genes by Kameda & Kato (2011) noted that Blanfordia integra is undoubtedly a member of the genus Fukuia. As early as 1979, ... Annandale N. (1924). "The molluscan hosts of the human blood fluke in China and Japan and species liable to be confused with ...
Bartsch P. (1936). "Molluscan intermediate hosts of the Asiatic blood fluke, Schistosoma japonicum, and species confused with ... genes by Kameda & Kato (2011) noted that Blanfordia integra is undoubtedly a member of the genus Fukuia. This species is ...
"The Sinbad retrotransposon from the genome of the human blood fluke, Schistosoma mansoni, and the distribution of related Pao- ... Liang, Kung-Hao; Yeh, Chau-Ting (2013). "A gene expression restriction network mediated by sense and antisense Alu sequences ... and BEL-Pao-like groups based on both their degree of sequence similarity and the order of encoded gene products. Ty1-copia and ... both LINEs and SINEs were incorporated into novel genes so as to evolve new functionality. Long INterspersed Elements (LINE) ...
... is a digenetic, two-host blood fluke in cattle. It is one of nine Schistosoma species that share a similar ... and other closely related schistosomes by polymerase chain reaction amplification of a species specific mitochondrial gene". ... Schistosoma bovis is a two-host blood fluke, that causes intestinal schistosomiasis in ruminants in North Africa, Mediterranean ... The cercariae enter the host's blood stream, and travel to the liver to mature into adult flukes. Adult flukes can coat ...
2009). "The genome of the blood fluke Schistosoma mansoni". Nature. 460 (7253): 352-8. doi:10.1038/nature08160. PMC 2756445 . ... Gene. 574 (2): 273-86. doi:10.1016/j.gene.2015.08.022. PMID 26275937. CS1 maint: Explicit use of et al. (link) CS1 maint: ... CS1 maint: Multiple names: authors list (link) Liu B, Davis TM (2011) Conservation and loss of ribosomal RNA gene sites in ... comparative gene mapping between a species with a low-number karyotype and the model species of Lepidoptera" (PDF). Insect ...
"An Approach to Revealing Blood Fluke Life Cycles, Taxonomy, and Diversity: Provision of Key Reference Data Including Dna ... genes shows phylogenic relations of species in the genus Schistosoma: This article incorporates CC-BY-2.0 text from the ... The definitive hosts of Schistosoma spindale are (mainly) ruminants and Schistosoma spindale cause intestinal schistosomiasis ... "The complete mitochondrial genomes of Schistosoma haematobium and Schistosoma spindale and the evolutionary history of ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium * ... Nakano T, Okamoto M, Ikeda Y, Hasegawa H (December 2006). "Mitochondrial cytochrome c oxidase subunit 1 gene and nuclear rDNA ...
The disease is caused by several flukes of the genus Schistosoma, which can bore through human skin. The people most at risk ... Lockyer, A.E.; Olson, P.D. & Littlewood, D.T.J. (2003). "Utility of complete large and small subunit rRNA genes in resolving ... The adults use a relatively large, muscular pharynx to ingest cells, cell fragments, mucus, body fluids or blood. In both the ... Miracidium Schistosoma Regenerative medicine Dentzien-Dias, PC; Poinar, G Jr; de Figueiredo, AE; Pacheco, AC; Horn, BL; Schultz ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni/japonicum/mekongi/haematobium *Schistosomiasis ... Lockyer, A.E.; Olson, P.D. & Littlewood, D.T.J. (2003). "Utility of complete large and small subunit rRNA genes in resolving ... The disease is caused by several flukes of the genus Schistosoma, which can bore through human skin. The people most at risk ... These are often called flukes, as most have flat rhomboid shapes like that of a flounder (Old English flóc). There are about ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium * ... "Differentiating Dracunculus medinensis from D. insignis, by the sequence analysis of the 18S rRNA gene" (PDF). Annals of ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium / S. ... The total genome size of O. volvulus is 1.5x108 BP and contains around 4,000 genes, with genes for collagen and cuticular ... The microfilariae are taken up by a female blackfly when she takes a blood meal, thus completing the lifecycle of O. volvulus.[ ... They may be able to trigger blood-vessel formation because dense vascular networks are often found surrounding the worms.[5] ...
Oncogenes are genes that promote cell growth and reproduction. Tumor suppressor genes are genes that inhibit cell division and ... While low blood levels of vitamin D are correlated with increased cancer risk, whether this relationship is causal and vitamin ... Parasitic infections associated with cancer include Schistosoma haematobium (squamous cell carcinoma of the bladder) and the ... liver flukes, Opisthorchis viverrini and Clonorchis sinensis (cholangiocarcinoma). Up to 10% of invasive cancers are related to ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni/japonicum/mekongi/haematobium *Schistosomiasis ... "The complete mitochondrial genomes of three parasitic nematodes of birds: a unique gene order and insights into nematode ...
However, elevated blood eosinophil counts may not occur during the early phase of the disorder. Other, less specific laboratory ... Clonal eosinophilia caused by mutations in genes that are highly susceptible to tyrosine kinase inhibitors such as PDGFRA, ... Zhang Y, Ma L (2017). "Repeated Prosthetic Mitral Valve Thrombosis in Fluke Infection Induced Hypereosinophilic Syndrome". The ... Schistosoma, filaria, Trematoda, and Nematode species. Parasitic infestations often cause significant heart valve disease along ...
Fluke/trematode. (Trematode infection). Blood fluke. *Schistosoma mansoni / S. japonicum / S. mekongi / S. haematobium / S. ... Using CRISPR gene editing technology, researchers decreased the symptoms due to schistosomiasis in an animal model.[71] ... The worms of S. haematobium migrate to the veins around the bladder and ureters.[21] This can lead to blood in the urine 10 to ... Abdominal pain, diarrhea, bloody stool, blood in the urine[5]. Complications. Liver damage, kidney failure, infertility, ...
Oncogenes are genes that promote cell growth and reproduction. Tumor suppressor genes are genes that inhibit cell division and ... The use of heparin appears to improve survival and decrease the risk of blood clots.[169][needs update] ... and the liver flukes, Opisthorchis viverrini and Clonorchis sinensis (cholangiocarcinoma).[50] ... Parasitic infections associated with cancer include Schistosoma haematobium (squamous cell carcinoma of the bladder) ...
Oncogenes are genes that promote cell growth and reproduction. Tumor suppressor genes are genes that inhibit cell division and ... People with cancer have an increased risk of blood clots in their veins which can be life-threatening.[176] The use of blood ... and the liver flukes, Opisthorchis viverrini and Clonorchis sinensis (cholangiocarcinoma).[54] ... Parasitic infections associated with cancer include Schistosoma haematobium (squamous cell carcinoma of the bladder) ...
Praziquantel - effective against flatworms (e.g., tapeworms and schistosoma). *Octadepsipeptides (e.g. Emodepside) - effective ... genes. Resistant varieties accumulate, and treatment failure finally occurs. ... Triclabendazole - effective against liver flukes. *Flubendazole - effective against most intestinal parasites. *Abamectin (and ... Blood and blood. forming organs (B). *Antithrombotics *Antiplatelets. *Anticoagulants. *Thrombolytics/fibrinolytics. * ...
Proteome analysis of the male schistosome esophagus identified 13 proteins encoded by microexon genes (MEGs), 11 of which were ... Leandro X. et, al, Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma ... Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints ... Schistosomes are blood-dwelling helminth parasites that cause schistosomiasis, a debilitating disease resulting in inflammation ...
... and evaluation of expressed sequence tags from different developmental stages of the Asian blood fluke Schistosoma japonicum. ... PENG H.J., CHEN X.G., WANG X.Z., LUN Z.R. 2003: Analysis of the gene expression profile of Schistosoma japonicum cercariae by a ... but not against the cercarial elastases of Schistosoma mansoni, Schistosoma haematobium, Schistosoma japonicum and ... FUNG M.C., LAUM.T., CHEN X.G. 2002: Expressed sequence tag (EST) analysis of a Schistosoma japonicum cercariae cDNA library. ...
It also induced differential expression of 820 genes, 168 genes being up-regulated and 652 genes being down-regulated, p value ... The present study provides a first report of microarray-based technology for describing changes in the splenic gene expression ... A functional study of these genes revealed changes in the pathways related to nitric oxide and reactive oxygen species ... The Ingenuity Pathway Analysis tool was then used for analysing differentially expressed gene identifiers for annotating bio- ...
Schistosoma mansoni (Blood fluke). Schistosoma haematobium (Blood fluke). Schistosoma curassoni. 284. UniRef50_Q26604. Cluster ... Schistosoma mansoni (Blood fluke). ,p>This subsection of the Names and taxonomy section shows the unique identifier assigned ... p>This subsection of the Names and taxonomy section indicates the name(s) of the gene(s) that code for the protein sequence(s ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ...
Schistosoma mansoni (Blood fluke). ,p>This subsection of the ,a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy% ... Gene expression databases. ExpressionAtlas, Differential and Baseline Expression. More...ExpressionAtlasi. C4QU59, ... p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of ... p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source ...
A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum ... Oligonucleotide microarray analysis of strain- and gender-associated gene expression in the human blood fluke, Schistosoma ... Global expression analysis revealed novel gender-specific gene expression features in the blood fluke parasite Schistosoma ... The genome of the blood fluke Schistosoma mansoni. Nature. 2009;460:352-8.View ArticlePubMedPubMed CentralGoogle Scholar. ...
Schistosoma mansoni is a water-borne parasite of humans, and belongs to the group of blood flukes (Schistosoma). The adult ... Portease included the invadolysin (host penetration) and cathepsin (blood-feeding) gene families. In 2012, an improved version ... July 2009). "The genome of the blood fluke Schistosoma mansoni". Nature. 460 (7253): 352-8. doi:10.1038/nature08160. PMC ... January 2012). "A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni". ...
Schistosoma japonicum, a human blood fluke, causes a parasitic disease affecting millions of people in Asia. Thioredoxin- ... Here we cloned the gene of S. japonicum thioredoxin (SjTrx), expressed and purified the recombinant SjTrx in Escherichia coli. ... Expression, characterization and crystal structure of thioredoxin from Schistosoma japonicum * YONGDONG LI, PAN LI, YUN PENG, ... Coordinated expression of these genes in the tissue may play an essential role in the maintenance of normal placentation and ...
Genomes and Genes, Publications, Research Topics, Patents about Schistosoma mansoni ... Cloning the genes and DNA binding properties of High Mobility Group B1 (HMGB1) proteins from the human blood flukes Schistosoma ... The blood flukes Schistosoma mansoni and Schistosoma japonicum inflict immense suffering as agents of human schistosomiasis... ... b>Schistosoma mansoni is one of the three major parasitic blood flukes and causes a hepatosplenic disease in humans. ...
of A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum ... of A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum ...
Gulliver, a long terminal repeat retrotransposon from the genome of the oriental blood fluke Schistosoma japonicum. ... Gene. *Gene Expression Omnibus (GEO) Database *Gene Expression Omnibus (GEO) Datasets. *Gene Expression Omnibus (GEO) Profiles ... non-long terminal repeat retrotransposon from the human blood fluke, Schistosoma japonicum. ... pido, a non-long terminal repeat retrotransposon of the chicken repeat 1 family from the genome of the Oriental blood fluke, ...
Gene: CDK5 , Review 45 of antibodies with 60 images, 39 of protocols, relevant gene trends, publication graphs, tissue ... Blood fluke CDK5 antibody; Schistosoma japonicum CDK5 antibody. C1L6Q8. 79.0%. ARP69686. Blood fluke CDK5 antibody; Schistosoma ... BioGPS Gene Atlas. 204247_s_at. CD33+_Myeloid. 27.150. 36.190. Details. BioGPS Gene Atlas. 204247_s_at. CD34+. 24.850. 36.190. ... BioGPS Gene Atlas. 204247_s_at. colon. 17.800. 36.190. Details. BioGPS Gene Atlas. 204247_s_at. pineal_day. 52.280. 36.190. ...
Schistosoma is a genus of trematodes, commonly known as blood-flukes. They are parasitic flatworms responsible for a highly ... genes shows phylogenic relations of species in the genus Schistosoma: Schistosoma japonicum Schistosoma haematobium Schistosoma ... The four species are Schistosoma bomfordi Schistosoma datta Schistosoma harinasutai Schistosoma turkestanicum The hybrid S. ... "A Systematically Improved High Quality Genome and Transcriptome of the Human Blood Fluke Schistosoma mansoni". PLoS Neglected ...
In this study, we surveyed the S. japonicum genome database for genes encoding nucleases. A total of 130 nucleases of 3 classes ... Transcriptional analysis of these genes using a genomic DNA microarray revealed that the majority of the nucleases were ... Recent advances in studies of the Schistosoma japonicum genome have opened new avenues for the elucidation of parasite biology ... Global expression analysis revealed novel gender-specific gene expression features in the blood fluke parasite Schistosoma ...
The factors that influence the codon usage bias are mutation pressure, natural selection, gene expression, gene length, GC ... codon usage bias was found to be low and gene expression was high. The nucleobase A and T were used most often than C and G. ... expression level and codon usage bias in the genes of these two species.After estimating the effective number of codon (ENC) in ... levels and codon usage patterns in nuclear genes of the filarial nematode Wucheraria bancrofti and the blood fluke Schistosoma ...
Genomes and Genes, Publications about Experts and Doctors on gene expression profiling in Brisbane, Queensland, Australia ... Transcriptomics tool for the human Schistosoma blood flukes using microarray gene expression profiling. Exp Parasitol. 2006;114 ... fms genes*viola*necator americanus*escherichia coli k12*exosomes*auranofin*pinctada*merkel cells*gammaretrovirus*neoplasm genes ... Gobert G, Moertel L, Brindley P, McManus D. Developmental gene expression profiles of the human pathogen Schistosoma japonicum ...
Rights & permissionsfor article The genome of the blood fluke ,i,Schistosoma mansoni,/i, . Opens in a new window. ... Evidence for lateral gene transfer between Archaea and Bacteria from genome sequence of Thermotoga maritima *Karen E. Nelson ... CloVR-Microbe: Assembly, gene finding and functional annotation of raw sequence data from single microbial genome projects - ... CloVR-Microbe: Assembly, gene finding and functional annotation of raw sequence data from single microbial genome projects - ...
... proteins from the human blood flukes Schistosoma mansoni and Schistosoma japonicum. Gene (Amsterdam). , v. 377, p. 33-45, 2006 ... Identification of the Schistosoma mansoni TNF-Alpha Receptor Gene and the Effect of Human TNF-Alpha on the Parasite Gene ... Schistosoma mansoni Egg, Adult Male and Female Comparative Gene Expression Analysis and Identification of Novel Genes by RNA- ... DEMARCO, Ricardo ; Verjovski-Almeida, S. . Expressed Sequence Tags (ESTs) and Gene Discovery: Schistosoma mansoni. In: Gruber, ...
The Genome of the blood fluke Schistosoma mansoni. Nature 460, 352-358. See also the press release about this paper (in German) ... Gene structure prediction by genomic sequence alignment (book chapter). In: Genetics, Genomics, Proteomics and Bioinformatics. ... Gene Prediction with a Hidden Markov Model and new Intron Submodel.. Bioinformatics 19, ii215-ii225 (ECCB 2003 special issue). ... Gene prediction in eukaryotes with a generalized hidden Markov model that uses hints from external sources. BMC Bioinformatics ...
2012 A systematically improved high quality genome and transcriptome of the human blood fluke Schistosoma mansoni. PLoS Negl. ... More than half (PA-Microphallus: 51.7%; PE-Microphallus: 51.2%) of the BUSCO genes are retained in this reduced gene set, ... The presence of genes involved in hydrolase activity among genes that were significantly functionally enriched is interesting ... This analysis allowed us to (1) identify potential among-gene interactions, (2) identify sets of interacting genes of relevance ...
Miltefosine proved to have in vitro ovicidal, schistolarvicidal and lethal activity on adult worms of both Schistosoma species ... a similar in vitro study was carried out on the adult stage of Schistosoma haematobium, the second major human species, its ... an in vitro study was carried out to investigate whether it has a biocidal activity against the aquatic stages of Schistosoma ... of novel antischistosomal derivatives with potent activity in vivo against different developmental stages of Schistosoma ...
A next-generation microarray further reveals stage-enriched gene expression pattern in the blood fluke Schistosoma japonicum. ... Gene Expression Omnibus (GEO): A gene expression/molecular abundance repository and a curated, online resource for gene ... CleanEx: A Database of Heterogeneous Gene Expression Data Based on A Consistent Gene Nomenclature ... Learn to use the Allen Mouse Brain Atlas, from the Allen Brain Institute, a database of spatially mapped large-scale gene ...
... piggyBac transposon mediated transgenesis of the human blood fluke, Schistosoma mansoni. FASEB J. 21, 3479-3489. Abstract ... Methods for gene transfer. 4. Future priorities. 4.1. Strongyloides spp.. 4.2. Brugia spp.. 5. References. ... source of whole blood (either a laboratory animal or other source) for blood feeding mosquitoes to support egg production, and ... Examples of this would be in situ expression of interfering RNAs or of gene constructs designed to give dominant loss- or gain- ...
... cloning and characterization of a phospholipid hydroperoxide glutathione peroxidase gene from a blood fluke Schistosoma ... Expression and characterization of glutathione peroxidase activity in the human blood fluke Schistosoma mansoni. Infect Immun ... Mei H, LoVerde PT (1995) Schistosoma mansoni: cloning the gene encoding glutathione peroxidase. Exp Parasitol 80:319-322 ... Expression and characterization of a phospholipid hydroperoxide glutathione peroxidase gene in Schistosoma japonicum. ...
To decipher the functional roles of vasa/PL10-like genes in the human blood fluke Schistosoma mansoni, we performed RNA ... Functional analysis of vasa/PL10-like genes in the ovary of Schistosoma mansoni ... Interactions of amphipathic α-helical MEG proteins from Schistosoma mansoni with membranes ... Doubled stranded RNA targeting the schistosome vasa-like gene Smvlg1 reduced the volume of the ovary. Changes in morphology of ...
  • The present study provides a first report of microarray-based technology for describing changes in the splenic gene expression profile for mice immunised with a highly effective, protection-inducing, multi-epitope, subunit-based, chemically-synthesised vaccine candidate against F. hepatica . (biomedcentral.com)
  • A functional study of these genes revealed changes in the pathways related to nitric oxide and reactive oxygen species production, Interleukin-12 signalling and production in macrophages and Interleukin-8 signalling with up-regulation of S100 calcium-binding protein A8, Matrix metallopeptidase 9 and CXC chemokine receptor 2 genes. (biomedcentral.com)
  • The Ingenuity Pathway Analysis tool was then used for analysing differentially expressed gene identifiers for annotating bio-functions and constructing and visualising molecular interaction networks. (biomedcentral.com)
  • Restriction fragment length polymorphism (RFLP) analysis employing a probe from the heat-inducible cytoplasmic HSP70 gene family hybridized with EcoR I-digested genomic DNA was used in the molecular typing of Trichomonas isolates. (ajtmh.org)
  • Functional genomic approaches could aid in identifying the role and importance of these newly described schistosome genes. (gwu.edu)
  • Although most LTR retrotransposons have common structural features and encode similar genes, there is nonetheless considerable diversity in their genomic organization, reflecting the different strategies they use to proliferate within the genomes of their hosts. (biomedcentral.com)
  • Although all are flanked by LTRs and encode gag and pol genes, the lineages diverge considerably in their DNA sequences and genomic organization. (biomedcentral.com)
  • The concept of a genomic core, defined as the set of genes ubiquitous in all genomes of a monophyletic group, has become crucial in comparative and evolutionary genomics. (biomedcentral.com)
  • Abstract Objective Screening via non‐invasive prenatal testing (NIPT) involving the analysis of cell‐free DNA (cfDNA) from plasma has become readily available to screen for chromosomal and DNA aberrations through maternal blood. (bionity.com)
  • volume = {6}, number = {9}, pages = {e1001115}, abstract = {We have identified and characterized a Macrophage Migration Inhibitory Factor (MIF) family member in the Lophotrochozoan invertebrate, Biomphalaria glabrata, the snail intermediate host of the human blood fluke Schistosoma mansoni. (cnrs.fr)
  • So here we had a magnificent example of long-term monogamy in parasitic flatworms of all things-a model for all of us to emulate (except for the blood-sucking, the living inside someone's abdomen, and all the other minor differences). (nationalgeographic.com)
  • PMID 19254294 ] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort. (snpedia.com)
  • The LTRs are the direct sequence repeats that flank the internal coding region, which - in all autonomous (functional) LTR retrotransposons - includes genes encoding both structural and enzymatic proteins. (biomedcentral.com)
  • METHODS: We used flow cytometry and undertook a systemic approach to examine the frequency, immunophenotyping and functional properties of CD8+CD57+ T cells in the peripheral blood, tumor tissue and the corresponding normal tissue, as well as lung draining lymph nodes, of patients with NSCLC. (bvsalud.org)
  • Analysis of the ratio between synonymous and nonsynonymous substitution rates (dN/dS) in the comparison between schistosome orthologs for the two classes of genes reveals significantly higher values when compared with a set of a control genes coding for secreted proteins, and for proteins previously localized in the tegument. (cdc.gov)
  • Leandro X. et, al, Quantitative Proteomics of Enriched Esophageal and Gut Tissues from the Human Blood Fluke Schistosoma mansoni Pinpoints Secreted Proteins for Vaccine Development , https://doi.org/10.1021/acs.jproteome.9b00531 Nov. 15, 2019. (bioinfor.com)
  • Proteome analysis of the male schistosome esophagus identified 13 proteins encoded by microexon genes (MEGs), 11 of which were uniquely located in the esophageal glands. (bioinfor.com)
  • The gag gene encodes structural proteins that form the virus-like particle (VLP), inside which reverse transcription takes place. (biomedcentral.com)
  • In total, 90 genes were differentially expressed, mainly those involved in cellular redox homeostasis, metabolism and small molecule transport but also cysteine proteases and structural proteins of the giardin family. (mcarthurbioinformatics.ca)
  • All clusters included known genes and pathways as well as proteins unique to Giardia or diplomonads. (mcarthurbioinformatics.ca)
  • These MEGs, or microexon genes, have the hallmarks of secreted proteins and are expressed in the intramammalian stages of the life cycle. (blogspot.com)
  • The study will provide novel insights into the evolution of human parasite genomes, identify gene functions and pathways important for the parasite-host interaction and reveal novel candidate drug and vaccine targets. (cgenome.net)
  • This set is useful for gene annotation but also a reference to evaluate the diversity of, and the relationships among, the different families. (biomedcentral.com)
  • Epigenetic modification of cytosine methylation works as a key process affecting phenotypic plasticity and adaptation and regulating gene transcription profiles [ 10 ]. (ijbs.com)
  • Interestingly, a QTL cluster at Lca371 underlying growth traits of Asian seabass showed similarity to the cathepsin D gene of human, which is related to cancer and Alzheimer's disease. (biomedcentral.com)
  • We generated 21440 SAGE tags and mapped 13381 to the S. mansoni gene predictions (v4.0e) either by estimating theoretical 3′ UTR lengths or using existing 3′ EST sequence data. (mcarthurbioinformatics.ca)
  • DNA sequences were obtained from the ITS2 and CO1 genes and phylogenetic trees were constructed from the results. (bvsalud.org)
  • Here, we report a high-resolution linkage map with 790 microsatellites and SNPs, comparative analysis of synteny, fine-mapping of QTL and the identification of potential candidate genes for growth traits. (biomedcentral.com)
  • We constructed a high resolution linkage map, carried out comparative mapping, refined the positions of QTL, identified candidate genes for growth traits and analyzed their effects on growth. (biomedcentral.com)
  • CD8+CD57+ T cells in the corresponding normal lung tissues shared similarities with their counterparts in peripheral blood rather than their counterparts in tumors. (bvsalud.org)
  • MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. (bionity.com)
  • The genes, amplified in up to six copies, encode molecules involved in cell cycle regulation, cell division, drug resistance, erythrocyte invasion, sexual differentiation and unknown functions. (ki.se)
  • An antibody library or an antibody fragment of interest (small molecular weight antibody), and a gene of the antibody is obtained. (theeca.com)