Substances that are recognized by the immune system and induce an immune reaction.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Differentiation antigens found on thymocytes and on cytotoxic and suppressor T-lymphocytes. CD8 antigens are members of the immunoglobulin supergene family and are associative recognition elements in MHC (Major Histocompatibility Complex) Class I-restricted interactions.
Proteins, glycoprotein, or lipoprotein moieties on surfaces of tumor cells that are usually identified by monoclonal antibodies. Many of these are of either embryonic or viral origin.
Complex of at least five membrane-bound polypeptides in mature T-lymphocytes that are non-covalently associated with one another and with the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL). The CD3 complex includes the gamma, delta, epsilon, zeta, and eta chains (subunits). When antigen binds to the T-cell receptor, the CD3 complex transduces the activating signals to the cytoplasm of the T-cell. The CD3 gamma and delta chains (subunits) are separate from and not related to the gamma/delta chains of the T-cell receptor (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA).
Antigens on surfaces of cells, including infectious or foreign cells or viruses. They are usually protein-containing groups on cell membranes or walls and may be isolated.
Substances elaborated by bacteria that have antigenic activity.
A bifunctional enzyme that catalyzes the synthesis and HYDROLYSIS of CYCLIC ADP-RIBOSE (cADPR) from NAD+ to ADP-RIBOSE. It is a cell surface molecule which is predominantly expressed on LYMPHOID CELLS and MYELOID CELLS.
Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.
Differentiation antigens expressed on B-lymphocytes and B-cell precursors. They are involved in regulation of B-cell proliferation.
A member of the tumor necrosis factor receptor superfamily with specificity for CD40 LIGAND. It is found on mature B-LYMPHOCYTES and some EPITHELIAL CELLS, lymphoid DENDRITIC CELLS. Evidence suggests that CD40-dependent activation of B-cells is important for generation of memory B-cells within the germinal centers. Mutations of the gene for CD40 antigen result in HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 3. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
A membrane glycoprotein and differentiation antigen expressed on the surface of T-cells that binds to CD40 ANTIGENS on B-LYMPHOCYTES and induces their proliferation. Mutation of the gene for CD40 ligand is a cause of HYPER-IGM IMMUNODEFICIENCY SYNDROME, TYPE 1.
Unglycosylated phosphoproteins expressed only on B-cells. They are regulators of transmembrane Ca2+ conductance and thought to play a role in B-cell activation and proliferation.
Substances elaborated by viruses that have antigenic activity.
Costimulatory T-LYMPHOCYTE receptors that have specificity for CD80 ANTIGEN and CD86 ANTIGEN. Activation of this receptor results in increased T-cell proliferation, cytokine production and promotion of T-cell survival.
Acidic sulfated integral membrane glycoproteins expressed in several alternatively spliced and variable glycosylated forms on a wide variety of cell types including mature T-cells, B-cells, medullary thymocytes, granulocytes, macrophages, erythrocytes, and fibroblasts. CD44 antigens are the principle cell surface receptors for hyaluronate and this interaction mediates binding of lymphocytes to high endothelial venules. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Differentiation antigens expressed on pluripotential hematopoietic cells, most human thymocytes, and a major subset of peripheral blood T-lymphocytes. They have been implicated in integrin-mediated cellular adhesion and as signalling receptors on T-cells.
Glycolipid-anchored membrane glycoproteins expressed on cells of the myelomonocyte lineage including monocytes, macrophages, and some granulocytes. They function as receptors for the complex of lipopolysaccharide (LPS) and LPS-binding protein.
Glycoprotein members of the immunoglobulin superfamily which participate in T-cell adhesion and activation. They are expressed on most peripheral T-lymphocytes, natural killer cells, and thymocytes, and function as co-receptors or accessory molecules in the T-cell receptor complex.
Ratio of T-LYMPHOCYTES that express the CD4 ANTIGEN to those that express the CD8 ANTIGEN. This value is commonly assessed in the diagnosis and staging of diseases affecting the IMMUNE SYSTEM including HIV INFECTIONS.
Glycoproteins expressed on all mature T-cells, thymocytes, and a subset of mature B-cells. Antibodies specific for CD5 can enhance T-cell receptor-mediated T-cell activation. The B-cell-specific molecule CD72 is a natural ligand for CD5. (From Abbas et al., Cellular and Molecular Immunology, 2d ed, p156)
Antigens expressed primarily on the membranes of living cells during sequential stages of maturation and differentiation. As immunologic markers they have high organ and tissue specificity and are useful as probes in studies of normal cell development as well as neoplastic transformation.
A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes.
Glycoproteins expressed on cortical thymocytes and on some dendritic cells and B-cells. Their structure is similar to that of MHC Class I and their function has been postulated as similar also. CD1 antigens are highly specific markers for human LANGERHANS CELLS.
Antibodies produced by a single clone of cells.
The 140 kDa isoform of NCAM (neural cell adhesion molecule) containing a transmembrane domain and short cytoplasmic tail. It is expressed by all lymphocytes mediating non-MHC restricted cytotoxicity and is present on some neural tissues and tumors.
Antigens expressed on the cell membrane of T-lymphocytes during differentiation, activation, and normal and neoplastic transformation. Their phenotypic characterization is important in differential diagnosis and studies of thymic ontogeny and T-cell function.
A membrane-bound or cytosolic enzyme that catalyzes the synthesis of CYCLIC ADP-RIBOSE (cADPR) from nicotinamide adenine dinucleotide (NAD). This enzyme generally catalyzes the hydrolysis of cADPR to ADP-RIBOSE, as well, and sometimes the synthesis of cyclic ADP-ribose 2' phosphate (2'-P-cADPR) from NADP.
Surface antigens expressed on myeloid cells of the granulocyte-monocyte-histiocyte series during differentiation. Analysis of their reactivity in normal and malignant myelomonocytic cells is useful in identifying and classifying human leukemias and lymphomas.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CTLA-4 ANTIGEN with high specificity and to CD28 ANTIGEN with low specificity. The interaction of CD80 with CD28 ANTIGEN provides a costimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Tetraspanin proteins found at high levels in cells of the lymphoid-myeloid lineage. CD53 antigens may be involved regulating the differentiation of T-LYMPHOCYTES and the activation of B-LYMPHOCYTES.
A cell adhesion protein that was originally identified as a heat stable antigen in mice. It is involved in METASTASIS and is highly expressed in many NEOPLASMS.
Zinc-binding metalloproteases that are members of the type II integral membrane metalloproteases. They are expressed by GRANULOCYTES; MONOCYTES; and their precursors as well as by various non-hematopoietic cells. They release an N-terminal amino acid from a peptide, amide or arylamide.
Any part or derivative of any protozoan that elicits immunity; malaria (Plasmodium) and trypanosome antigens are presently the most frequently encountered.
Lymphocytes responsible for cell-mediated immunity. Two types have been identified - cytotoxic (T-LYMPHOCYTES, CYTOTOXIC) and helper T-lymphocytes (T-LYMPHOCYTES, HELPER-INDUCER). They are formed when lymphocytes circulate through the THYMUS GLAND and differentiate to thymocytes. When exposed to an antigen, they divide rapidly and produce large numbers of new T cells sensitized to that antigen.
A costimulatory ligand expressed by ANTIGEN-PRESENTING CELLS that binds to CD28 ANTIGEN with high specificity and to CTLA-4 ANTIGEN with low specificity. The interaction of CD86 with CD28 ANTIGEN provides a stimulatory signal to T-LYMPHOCYTES, while its interaction with CTLA-4 ANTIGEN may play a role in inducing PERIPHERAL TOLERANCE.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
Lymphoid cells concerned with humoral immunity. They are short-lived cells resembling bursa-derived lymphocytes of birds in their production of immunoglobulin upon appropriate stimulation.
Polyomavirus antigens which cause infection and cellular transformation. The large T antigen is necessary for the initiation of viral DNA synthesis, repression of transcription of the early region and is responsible in conjunction with the middle T antigen for the transformation of primary cells. Small T antigen is necessary for the completion of the productive infection cycle.
A tumor necrosis factor receptor subtype found in a variety of tissues and on activated LYMPHOCYTES. It has specificity for FAS LIGAND and plays a role in regulation of peripheral immune responses and APOPTOSIS. Multiple isoforms of the protein exist due to multiple ALTERNATIVE SPLICING. The activated receptor signals via a conserved death domain that associates with specific TNF RECEPTOR-ASSOCIATED FACTORS in the CYTOPLASM.
Antigens determined by leukocyte loci found on chromosome 6, the major histocompatibility loci in humans. They are polypeptides or glycoproteins found on most nucleated cells and platelets, determine tissue types for transplantation, and are associated with certain diseases.
Membrane antigens associated with maturation stages of B-lymphocytes, often expressed in tumors of B-cell origin.
High-molecular weight glycoproteins uniquely expressed on the surface of LEUKOCYTES and their hemopoietic progenitors. They contain a cytoplasmic protein tyrosine phosphatase activity which plays a role in intracellular signaling from the CELL SURFACE RECEPTORS. The CD45 antigens occur as multiple isoforms that result from alternative mRNA splicing and differential usage of three exons.
Process of classifying cells of the immune system based on structural and functional differences. The process is commonly used to analyze and sort T-lymphocytes into subsets based on CD antigens by the technique of flow cytometry.
Substances of fungal origin that have antigenic activity.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
The major group of transplantation antigens in the mouse.
A 67-kDa sialic acid binding lectin that is specific for MYELOID CELLS and MONOCYTE-MACROPHAGE PRECURSOR CELLS. This protein is the smallest siglec subtype and contains a single immunoglobulin C2-set domain. It may play a role in intracellular signaling via its interaction with SHP-1 PROTEIN-TYROSINE PHOSPHATASE and SHP-2 PROTEIN-TYROSINE PHOSPHATASE.
Any part or derivative of a helminth that elicits an immune reaction. The most commonly seen helminth antigens are those of the schistosomes.
Molecules on the surface of T-lymphocytes that recognize and combine with antigens. The receptors are non-covalently associated with a complex of several polypeptides collectively called CD3 antigens (ANTIGENS, CD3). Recognition of foreign antigen and the major histocompatibility complex is accomplished by a single heterodimeric antigen-receptor structure, composed of either alpha-beta (RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA) or gamma-delta (RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA) chains.
Cell-surface glycoprotein beta-chains that are non-covalently linked to specific alpha-chains of the CD11 family of leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE-ADHESION). A defect in the gene encoding CD18 causes LEUKOCYTE-ADHESION DEFICIENCY SYNDROME.
Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION.
A member of the tumor necrosis factor receptor superfamily that may play a role in the regulation of NF-KAPPA B and APOPTOSIS. They are found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; NEUTROPHILS; EOSINOPHILS; MAST CELLS and NK CELLS. Overexpression of CD30 antigen in hematopoietic malignancies make the antigen clinically useful as a biological tumor marker. Signaling of the receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Glycoproteins found on the membrane or surface of cells.
A critical subpopulation of regulatory T-lymphocytes involved in MHC Class I-restricted interactions. They include both cytotoxic T-lymphocytes (T-LYMPHOCYTES, CYTOTOXIC) and CD8+ suppressor T-lymphocytes.
Sites on an antigen that interact with specific antibodies.
A subtype of tetraspanin proteins that play a role in cell adhesion, cell motility, and tumor metastasis. CD9 antigens take part in the process of platelet activation and aggregation, the formation of paranodal junctions in neuronal tissue, and the fusion of sperm with egg.
A glycoprotein that is secreted into the luminal surface of the epithelia in the gastrointestinal tract. It is found in the feces and pancreaticobiliary secretions and is used to monitor the response to colon cancer treatment.
A subclass of HLA-D antigens that consist of alpha and beta chains. The inheritance of HLA-DR antigens differs from that of the HLA-DQ ANTIGENS and HLA-DP ANTIGENS.
A trisaccharide antigen expressed on glycolipids and many cell-surface glycoproteins. In the blood the antigen is found on the surface of NEUTROPHILS; EOSINOPHILS; and MONOCYTES. In addition, CD15 antigen is a stage-specific embryonic antigen.
Those proteins recognized by antibodies from serum of animals bearing tumors induced by viruses; these proteins are presumably coded for by the nucleic acids of the same viruses that caused the neoplastic transformation.
Established cell cultures that have the potential to propagate indefinitely.
A sialic acid-rich protein and an integral cell membrane mucin. It plays an important role in activation of T-LYMPHOCYTES.
Leukocyte differentiation antigens and major platelet membrane glycoproteins present on MONOCYTES; ENDOTHELIAL CELLS; PLATELETS; and mammary EPITHELIAL CELLS. They play major roles in CELL ADHESION; SIGNAL TRANSDUCTION; and regulation of angiogenesis. CD36 is a receptor for THROMBOSPONDINS and can act as a scavenger receptor that recognizes and transports oxidized LIPOPROTEINS and FATTY ACIDS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A group of three different alpha chains (CD11a, CD11b, CD11c) that are associated with an invariant CD18 beta chain (ANTIGENS, CD18). The three resulting leukocyte-adhesion molecules (RECEPTORS, LEUKOCYTE ADHESION) are LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1; MACROPHAGE-1 ANTIGEN; and ANTIGEN, P150,95.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
A group of antigens that includes both the major and minor histocompatibility antigens. The former are genetically determined by the major histocompatibility complex. They determine tissue type for transplantation and cause allograft rejections. The latter are systems of allelic alloantigens that can cause weak transplant rejection.
Small glycoproteins found on both hematopoietic and non-hematopoietic cells. CD59 restricts the cytolytic activity of homologous complement by binding to C8 and C9 and blocking the assembly of the membrane attack complex. (From Barclay et al., The Leukocyte Antigen FactsBook, 1993, p234)
IMMUNOGLOBULINS on the surface of B-LYMPHOCYTES. Their MESSENGER RNA contains an EXON with a membrane spanning sequence, producing immunoglobulins in the form of type I transmembrane proteins as opposed to secreted immunoglobulins (ANTIBODIES) which do not contain the membrane spanning segment.
Nuclear antigen with a role in DNA synthesis, DNA repair, and cell cycle progression. PCNA is required for the coordinated synthesis of both leading and lagging strands at the replication fork during DNA replication. PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types.
Oligosaccharide antigenic determinants found principally on NK cells and T-cells. Their role in the immune response is poorly understood.
A transmembrane protein belonging to the tumor necrosis factor superfamily that specifically binds to CD27 ANTIGEN. It is found on activated T-LYMPHOCYTES; B-LYMPHOCYTES; and DENDRITIC CELLS where it plays a role in stimulating the proliferation of CD4-POSITIVE T-LYMPHOCYTES and CD8-POSITIVE T-LYMPHOCYTES.
A ubiquitously expressed complement receptor that binds COMPLEMENT C3B and COMPLEMENT C4B and serves as a cofactor for their inactivation. CD46 also interacts with a wide variety of pathogens and mediates immune response.
A class of animal lectins that bind to carbohydrate in a calcium-dependent manner. They share a common carbohydrate-binding domain that is structurally distinct from other classes of lectins.
Glycoproteins with a wide distribution on hematopoietic and non-hematopoietic cells and strongly expressed on macrophages. CD58 mediates cell adhesion by binding to CD2; (ANTIGENS, CD2); and this enhances antigen-specific T-cell activation.
55-kDa antigens found on HELPER-INDUCER T-LYMPHOCYTES and on a variety of other immune cell types. CD4 antigens are members of the immunoglobulin supergene family and are implicated as associative recognition elements in MAJOR HISTOCOMPATIBILITY COMPLEX class II-restricted immune responses. On T-lymphocytes they define the helper/inducer subset. CD4 antigens also serve as INTERLEUKIN-15 receptors and bind to the HIV receptors, binding directly to the HIV ENVELOPE PROTEIN GP120.
A ubiquitously expressed membrane glycoprotein. It interacts with a variety of INTEGRINS and mediates responses to EXTRACELLULAR MATRIX PROTEINS.
A CD antigen that contains a conserved I domain which is involved in ligand binding. When combined with CD18 the two subunits form MACROPHAGE-1 ANTIGEN.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.
An integrin alpha subunit of approximately 150-kDa molecular weight. It is expressed at high levels on monocytes and combines with CD18 ANTIGEN to form the cell surface receptor INTEGRIN ALPHAXBETA2. The subunit contains a conserved I-domain which is characteristic of several of alpha integrins.
The lipopolysaccharide-protein somatic antigens, usually from gram-negative bacteria, important in the serological classification of enteric bacilli. The O-specific chains determine the specificity of the O antigens of a given serotype. O antigens are the immunodominant part of the lipopolysaccharide molecule in the intact bacterial cell. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A specific HLA-A surface antigen subtype. Members of this subtype contain alpha chains that are encoded by the HLA-A*02 allele family.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Progenitor cells from which all blood cells derive.
The number of CD4-POSITIVE T-LYMPHOCYTES per unit volume of BLOOD. Determination requires the use of a fluorescence-activated flow cytometer.
The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B.
Carbohydrate antigens expressed by malignant tissue. They are useful as tumor markers and are measured in the serum by means of a radioimmunoassay employing monoclonal antibodies.
GPI-linked membrane proteins broadly distributed among hematopoietic and non-hematopoietic cells. CD55 prevents the assembly of C3 CONVERTASE or accelerates the disassembly of preformed convertase, thus blocking the formation of the membrane attack complex.
Cell adhesion molecules present on virtually all monocytes, platelets, and granulocytes. CD31 is highly expressed on endothelial cells and concentrated at the junctions between them.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
Membrane glycoproteins consisting of an alpha subunit and a BETA 2-MICROGLOBULIN beta subunit. In humans, highly polymorphic genes on CHROMOSOME 6 encode the alpha subunits of class I antigens and play an important role in determining the serological specificity of the surface antigen. Class I antigens are found on most nucleated cells and are generally detected by their reactivity with alloantisera. These antigens are recognized during GRAFT REJECTION and restrict cell-mediated lysis of virus-infected cells.
Tetraspanin proteins that are involved in a variety of cellular functions including BASEMENT MEMBRANE assembly, and in the formation of a molecular complexes on the surface of LYMPHOCYTES.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
A member of the tumor necrosis factor receptor superfamily that is specific for 4-1BB LIGAND. It is found in a variety of immune cell types including activated T-LYMPHOCYTES; NATURAL KILLER CELLS; and DENDRITIC CELLS. Activation of the receptor on T-LYMPHOCYTES plays a role in their expansion, production of cytokines and survival. Signaling by the activated receptor occurs through its association with TNF RECEPTOR-ASSOCIATED FACTORS.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Proteins prepared by recombinant DNA technology.
White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.
Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles.
Polymorphic class I human histocompatibility (HLA) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.
Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen.
Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION).
Receptors present on activated T-LYMPHOCYTES and B-LYMPHOCYTES that are specific for INTERLEUKIN-2 and play an important role in LYMPHOCYTE ACTIVATION. They are heterotrimeric proteins consisting of the INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT, the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT, and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN.
Sets of cell surface antigens located on BLOOD CELLS. They are usually membrane GLYCOPROTEINS or GLYCOLIPIDS that are antigenically distinguished by their carbohydrate moieties.
Those hepatitis B antigens found on the surface of the Dane particle and on the 20 nm spherical and tubular particles. Several subspecificities of the surface antigen are known. These were formerly called the Australia antigen.
Ubiquitously-expressed tetraspanin proteins that are found in late ENDOSOMES and LYSOSOMES and have been implicated in intracellular transport of proteins.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
The property of antibodies which enables them to react with some ANTIGENIC DETERMINANTS and not with others. Specificity is dependent on chemical composition, physical forces, and molecular structure at the binding site.
Tetraspanin proteins found associated with LAMININ-binding INTEGRINS. The CD151 antigens may play a role in the regulation of CELL MOTILITY.
A component of the B-cell antigen receptor that is involved in B-cell antigen receptor heavy chain transport to the PLASMA MEMBRANE. It is expressed almost exclusively in B-LYMPHOCYTES and serves as a useful marker for B-cell NEOPLASMS.
An encapsulated lymphatic organ through which venous blood filters.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
Human immune-response or Class II antigens found mainly, but not exclusively, on B-lymphocytes and produced from genes of the HLA-D locus. They are extremely polymorphic families of glycopeptides, each consisting of two chains, alpha and beta. This group of antigens includes the -DR, -DQ and -DP designations, of which HLA-DR is most studied; some of these glycoproteins are associated with certain diseases, possibly of immune etiology.
A membrane-bound tumor necrosis family member found primarily on activated T-LYMPHOCYTES that binds specifically to CD30 ANTIGEN. It may play a role in INFLAMMATION and immune regulation.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
A class of enzymes involved in the hydrolysis of the N-glycosidic bond of nitrogen-linked sugars.
A form of undifferentiated malignant LYMPHOMA usually found in central Africa, but also reported in other parts of the world. It is commonly manifested as a large osteolytic lesion in the jaw or as an abdominal mass. B-cell antigens are expressed on the immature cells that make up the tumor in virtually all cases of Burkitt lymphoma. The Epstein-Barr virus (HERPESVIRUS 4, HUMAN) has been isolated from Burkitt lymphoma cases in Africa and it is implicated as the causative agent in these cases; however, most non-African cases are EBV-negative.
Molecules on the surface of B- and T-lymphocytes that recognize and combine with specific antigens.
Deliberate stimulation of the host's immune response. ACTIVE IMMUNIZATION involves administration of ANTIGENS or IMMUNOLOGIC ADJUVANTS. PASSIVE IMMUNIZATION involves administration of IMMUNE SERA or LYMPHOCYTES or their extracts (e.g., transfer factor, immune RNA) or transplantation of immunocompetent cell producing tissue (thymus or bone marrow).
The production of ANTIBODIES by proliferating and differentiated B-LYMPHOCYTES under stimulation by ANTIGENS.
An alpha-integrin subunit found on lymphocytes, granulocytes, macrophages and monocytes. It combines with the integrin beta2 subunit (CD18 ANTIGEN) to form LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN-1.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
Antigens of the virion of the HEPATITIS B VIRUS or the Dane particle, its surface (HEPATITIS B SURFACE ANTIGENS), core (HEPATITIS B CORE ANTIGENS), and other associated antigens, including the HEPATITIS B E ANTIGENS.
The soft tissue filling the cavities of bones. Bone marrow exists in two types, yellow and red. Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. Red marrow is a hematopoietic tissue and is the site of production of erythrocytes and granular leukocytes. Bone marrow is made up of a framework of connective tissue containing branching fibers with the frame being filled with marrow cells.
The processes triggered by interactions of ANTIBODIES with their ANTIGENS.
Serum that contains antibodies. It is obtained from an animal that has been immunized either by ANTIGEN injection or infection with microorganisms containing the antigen.
The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)
Mice homozygous for the mutant autosomal recessive gene "scid" which is located on the centromeric end of chromosome 16. These mice lack mature, functional lymphocytes and are thus highly susceptible to lethal opportunistic infections if not chronically treated with antibiotics. The lack of B- and T-cell immunity resembles severe combined immunodeficiency (SCID) syndrome in human infants. SCID mice are useful as animal models since they are receptive to implantation of a human immune system producing SCID-human (SCID-hu) hematochimeric mice.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A heterogeneous group of immunocompetent cells that mediate the cellular immune response by processing and presenting antigens to the T-cells. Traditional antigen-presenting cells include MACROPHAGES; DENDRITIC CELLS; LANGERHANS CELLS; and B-LYMPHOCYTES. FOLLICULAR DENDRITIC CELLS are not traditional antigen-presenting cells, but because they hold antigen on their cell surface in the form of IMMUNE COMPLEXES for B-cell recognition they are considered so by some authors.
The type species of LYMPHOCRYPTOVIRUS, subfamily GAMMAHERPESVIRINAE, infecting B-cells in humans. It is thought to be the causative agent of INFECTIOUS MONONUCLEOSIS and is strongly associated with oral hairy leukoplakia (LEUKOPLAKIA, HAIRY;), BURKITT LYMPHOMA; and other malignancies.
T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.
Immunoglobulins produced in a response to BACTERIAL ANTIGENS.
Class I human histocompatibility (HLA) surface antigens encoded by more than 30 detectable alleles on locus B of the HLA complex, the most polymorphic of all the HLA specificities. Several of these antigens (e.g., HLA-B27, -B7, -B8) are strongly associated with predisposition to rheumatoid and other autoimmune disorders. Like other class I HLA determinants, they are involved in the cellular immune reactivity of cytolytic T lymphocytes.
The altered state of immunologic responsiveness resulting from initial contact with antigen, which enables the individual to produce antibodies more rapidly and in greater quantity in response to secondary antigenic stimulus.
Cells contained in the bone marrow including fat cells (see ADIPOCYTES); STROMAL CELLS; MEGAKARYOCYTES; and the immediate precursors of most blood cells.
The phenomenon of target cell destruction by immunologically active effector cells. It may be brought about directly by sensitized T-lymphocytes or by lymphoid or myeloid "killer" cells, or it may be mediated by cytotoxic antibody, cytotoxic factor released by lymphoid cells, or complement.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
A melanosome-specific protein that plays a role in the expression, stability, trafficking, and processing of GP100 MELANOMA ANTIGEN, which is critical to the formation of Stage II MELANOSOMES. The protein is used as an antigen marker for MELANOMA cells.
A widely distributed cell surface transmembrane glycoprotein that stimulates the synthesis of MATRIX METALLOPROTEINASES. It is found at high levels on the surface of malignant NEOPLASMS and may play a role as a mediator of malignant cell behavior.
A general term for various neoplastic diseases of the lymphoid tissue.
An albumin obtained from the white of eggs. It is a member of the serpin superfamily.
Antigens associated with specific proteins of the human adult T-cell immunodeficiency virus (HIV); also called HTLV-III-associated and lymphadenopathy-associated virus (LAV) antigens.
An inhibitory T CELL receptor that is closely related to CD28 ANTIGEN. It has specificity for CD80 ANTIGEN and CD86 ANTIGEN and acts as a negative regulator of peripheral T cell function. CTLA-4 antigen is believed to play role in inducing PERIPHERAL TOLERANCE.
A promyelocytic cell line derived from a patient with ACUTE PROMYELOCYTIC LEUKEMIA. HL-60 cells lack specific markers for LYMPHOID CELLS but express surface receptors for FC FRAGMENTS and COMPLEMENT SYSTEM PROTEINS. They also exhibit phagocytic activity and responsiveness to chemotactic stimuli. (From Hay et al., American Type Culture Collection, 7th ed, pp127-8)
A widely expressed transmembrane glycoprotein that functions as a METASTASIS suppressor protein. It is underexpressed in a variety of human NEOPLASMS.
Immunologic techniques based on the use of: (1) enzyme-antibody conjugates; (2) enzyme-antigen conjugates; (3) antienzyme antibody followed by its homologous enzyme; or (4) enzyme-antienzyme complexes. These are used histologically for visualizing or labeling tissue specimens.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
A group of differentiation surface antigens, among the first to be discovered on thymocytes and T-lymphocytes. Originally identified in the mouse, they are also found in other species including humans, and are expressed on brain neurons and other cells.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
The specific failure of a normally responsive individual to make an immune response to a known antigen. It results from previous contact with the antigen by an immunologically immature individual (fetus or neonate) or by an adult exposed to extreme high-dose or low-dose antigen, or by exposure to radiation, antimetabolites, antilymphocytic serum, etc.
Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.
A single, unpaired primary lymphoid organ situated in the MEDIASTINUM, extending superiorly into the neck to the lower edge of the THYROID GLAND and inferiorly to the fourth costal cartilage. It is necessary for normal development of immunologic function early in life. By puberty, it begins to involute and much of the tissue is replaced by fat.
Endogenous tissue constituents that have the ability to interact with AUTOANTIBODIES and cause an immune response.
A group of genetically identical cells all descended from a single common ancestral cell by mitosis in eukaryotes or by binary fission in prokaryotes. Clone cells also include populations of recombinant DNA molecules all carrying the same inserted sequence. (From King & Stansfield, Dictionary of Genetics, 4th ed)
Nuclear antigens encoded by VIRAL GENES found in HUMAN HERPESVIRUS 4. At least six nuclear antigens have been identified.
A soluble substance elaborated by antigen- or mitogen-stimulated T-LYMPHOCYTES which induces DNA synthesis in naive lymphocytes.
A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally being called a macroglobulin.
A cell line derived from cultured tumor cells.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
A sex-specific cell surface antigen produced by the sex-determining gene of the Y chromosome in mammals. It causes syngeneic grafts from males to females to be rejected and interacts with somatic elements of the embryologic undifferentiated gonad to produce testicular organogenesis.
A cell adhesion molecule of the immunoglobulin superfamily that is expressed in ENDOTHELIAL CELLS and is involved in INTERCELLULAR JUNCTIONS.
Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.
CD4-positive T cells that inhibit immunopathology or autoimmune disease in vivo. They inhibit the immune response by influencing the activity of other cell types. Regulatory T-cells include naturally occurring CD4+CD25+ cells, IL-10 secreting Tr1 cells, and Th3 cells.
Antibodies obtained from a single clone of cells grown in mice or rats.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.
A heterodimeric protein that is a cell surface antigen associated with lymphocyte activation. The initial characterization of this protein revealed one identifiable heavy chain (ANTIGENS, CD98 HEAVY CHAIN) and an indeterminate smaller light chain. It is now known that a variety of light chain subunits (ANTIGENS, CD98 LIGHT CHAINS) can dimerize with the heavy chain. Depending upon its light chain composition a diverse array of functions can be found for this protein. Functions include: type L amino acid transport, type y+L amino acid transport and regulation of cellular fusion.
The hepatitis B antigen within the core of the Dane particle, the infectious hepatitis virion.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
The complex formed by the binding of antigen and antibody molecules. The deposition of large antigen-antibody complexes leading to tissue damage causes IMMUNE COMPLEX DISEASES.
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.
The sum of the weight of all the atoms in a molecule.
Technique involving the diffusion of antigen or antibody through a semisolid medium, usually agar or agarose gel, with the result being a precipitin reaction.
A group of the D-related HLA antigens found to differ from the DR antigens in genetic locus and therefore inheritance. These antigens are polymorphic glycoproteins comprising alpha and beta chains and are found on lymphoid and other cells, often associated with certain diseases.
Immunoglobulins produced in response to VIRAL ANTIGENS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations, or by parent x offspring matings carried out with certain restrictions. All animals within an inbred strain trace back to a common ancestor in the twentieth generation.
A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.
Elements of limited time intervals, contributing to particular results or situations.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
An inhibitory B7 antigen that has specificity for the T-CELL receptor PROGRAMMED CELL DEATH 1 PROTEIN. CD274 antigen provides negative signals that control and inhibit T-cell responses and is found at higher than normal levels on tumor cells, suggesting its potential role in TUMOR IMMUNE EVASION.
Serologic tests based on inactivation of complement by the antigen-antibody complex (stage 1). Binding of free complement can be visualized by addition of a second antigen-antibody system such as red cells and appropriate red cell antibody (hemolysin) requiring complement for its completion (stage 2). Failure of the red cells to lyse indicates that a specific antigen-antibody reaction has taken place in stage 1. If red cells lyse, free complement is present indicating no antigen-antibody reaction occurred in stage 1.
A species of POLYOMAVIRUS originally isolated from Rhesus monkey kidney tissue. It produces malignancy in human and newborn hamster kidney cell cultures.
Conjugated protein-carbohydrate compounds including mucins, mucoid, and amyloid glycoproteins.
Substances that augment, stimulate, activate, potentiate, or modulate the immune response at either the cellular or humoral level. The classical agents (Freund's adjuvant, BCG, Corynebacterium parvum, et al.) contain bacterial antigens. Some are endogenous (e.g., histamine, interferon, transfer factor, tuftsin, interleukin-1). Their mode of action is either non-specific, resulting in increased immune responsiveness to a wide variety of antigens, or antigen-specific, i.e., affecting a restricted type of immune response to a narrow group of antigens. The therapeutic efficacy of many biological response modifiers is related to their antigen-specific immunoadjuvanticity.
Antigens that exist in alternative (allelic) forms in a single species. When an isoantigen is encountered by species members who lack it, an immune response is induced. Typical isoantigens are the BLOOD GROUP ANTIGENS.
Cells artificially created by fusion of activated lymphocytes with neoplastic cells. The resulting hybrid cells are cloned and produce pure MONOCLONAL ANTIBODIES or T-cell products, identical to those produced by the immunologically competent parent cell.
A melanosome-associated protein that plays a role in the maturation of the MELANOSOME.
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Bone marrow-derived lymphocytes that possess cytotoxic properties, classically directed against transformed and virus-infected cells. Unlike T CELLS; and B CELLS; NK CELLS are not antigen specific. The cytotoxicity of natural killer cells is determined by the collective signaling of an array of inhibitory and stimulatory CELL SURFACE RECEPTORS. A subset of T-LYMPHOCYTES referred to as NATURAL KILLER T CELLS shares some of the properties of this cell type.
A technique that combines protein electrophoresis and double immunodiffusion. In this procedure proteins are first separated by gel electrophoresis (usually agarose), then made visible by immunodiffusion of specific antibodies. A distinct elliptical precipitin arc results for each protein detectable by the antisera.
Form of passive immunization where previously sensitized immunologic agents (cells or serum) are transferred to non-immune recipients. When transfer of cells is used as a therapy for the treatment of neoplasms, it is called adoptive immunotherapy (IMMUNOTHERAPY, ADOPTIVE).
CD11a is one of the two components, along with CD18, which form lymphocyte function-associated antigen-1. Efalizumab acts as an ... ". "Entrez Gene: ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)". ... Integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide), also known as ITGAL, is ... CD11a+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGAL Info with links in the Cell ...
Because the CD18 gene has been cloned and sequenced, this disorder is a potential candidate for gene therapy. As of 2010[update ... including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The ... LAD1 is caused by mutations in the ITGB2 gene which are inherited autorecessively. This gene encodes CD18, a protein present in ... Candotti F, Fischer A. Gene therapy. In: Ochs HD, Smith CIE, Puck JM, eds. Primary immunodeficiency diseases: a molecular and ...
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in ... Binding of CD18 and CD11 results in the formation of Lymphocyte Functions Associated Antigen 1 (LFA-1), a protein found on B ... CD18+antigen at the US National Library of Medicine Medical Subject Headings (MeSH) ITGB2 Info with links in the Cell Migration ... CD18 also exists in soluble, ligand binding forms. Deficiencies in CD18 expression can lead to adhesion defects in circulating ...
LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16. Leukocyte ... LAD is a genetic defect caused by autosomal recessive genes. The deficiency causes ineffective migration and phagocytosis for ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ...
It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by rhinovirus as a receptor for entry into ... is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically ... Katz FE, Parkar M, Stanley K, Murray LJ, Clark EA, Greaves MF (Jan 1985). "Chromosome mapping of cell membrane antigens ... "Entrez Gene: intercellular adhesion molecule 1". Bella J, Kolatkar PR, Marlor CW, Greve JM, Rossmann MG (Apr 1998). "The ...
Target prediction indicated possibility of sRNA interaction with several virulence genes. This study confirmed the presence of ... Leukotoxin A: kills granulocytes, monocytes, and other white blood cells expressing integrin beta-2 (CD18) Cytolethal ... cells Inhibition of granulocyte functions Resistant to complement-mediated killing Lipopolysaccharides Surface antigens Heat ... small RNAs are involved in gene regulation. Jorth et al. identified 9 sRNA by Northern blotting from computer-predicted ...
"Entrez Gene: FHL2 four and a half LIM domains 2". Fimia GM, De Cesare D, Sassone-Corsi P (Nov 2000). "A family of LIM-only ... FHL2 has been shown to interact with: Androgen receptor, BRCA1, CTNNB1, CD18, CD29, CD49c, CREB1, EIF6, FHL3, IGFBP5, ITGA7, ... rise in circulatory prostate-specific antigen (PSA) levels after surgical or radiography treatment) FHL2 expression is ... Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. LIM proteins ...
MHC class-I-chain-related gene A (MICA) has also been proposed as an important tumor antigen recognized by Vδ1+ T cells. ... CD18, CD54). Thus activated Vγ9Vδ2 T cells behave like APCs (γδ T-APC) and present antigens to αβ T cells. This leads to turn ... The antigens recognized by non-Vδ2 T cells expanded in the above infectious contexts have not been characterized, but the fact ... One advantage and weakness of the Hayday nomenclature is that it is based on the gene order in the B6 genome, but this might ...
1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18 ... Identification of a gene cluster involved in cell adhesion.". J. Exp. Med. 167 (5): 1597-607. PMC 2188934. PMID 3284962. doi: ... Human CD Antigen Chart. *ITGAX Info with links in the Cell Migration Gateway ... A cadea alfa X de integrina combínase coa cadea beta 2 (CD18 ou ITGB2) para formar unha integrina específica de leucocitos ...
... antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of ... Skubitz KM, Campbell KD, Iida J, Skubitz AP (October 1996). "CD63 associates with tyrosine kinase activity and CD11/CD18, and ... Hotta H, Miyamoto H, Hara I, Takahashi N, Homma M (May 1992). "Genomic structure of the ME491/CD63 antigen gene and functional ... "Transcriptional enhancement of the human gene encoding for a melanoma-associated antigen (ME491) in association with malignant ...
Chart Human CD Antigen Chart ITGAX Info with links in the Cell Migration Gateway Human ITGAX genome location and ITGAX gene ... 1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". ... CD11c+Antigens at the US National Library of Medicine Medical Subject Headings (MeSH) Mouse CD Antigen ... Identification of a gene cluster involved in cell adhesion". J. Exp. Med. 167 (5): 1597-607. doi:10.1084/jem.167.5.1597. PMC ...
In 2000, she joined te Mount Sinai School of Medicine where she spent 11 years on the faculty in the Department of Gene and ... Collecting lymphatic vessel permeability facilitates adipose tissue inflammation and distribution of antigen to lymph node- ... role of intercellular adhesion molecule 1 and the CD11/CD18 integrins. Journal of Experimental Medicine, 183(2):451-462. PMCID ... She spearheaded early work on mouse macrophage gene expression, and her paper published as a part of the Immgen Project is the ...
"Entrez Gene: CCR6 chemokine (C-C motif) receptor 6".. *^ Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, ... 2002). "CCR6 colocalizes with CD18 and enhances adhesion to activated endothelial cells in CCR6-transduced Jurkat T cells". J. ... Ebert LM, McColl SR (2002). "Up-regulation of CCR5 and CCR6 on distinct subpopulations of antigen-activated CD4+ T lymphocytes ... Chemokine receptor 6 also known as CCR6 is a CC chemokine receptor protein which in humans is encoded by the CCR6 gene.[5] CCR6 ...
CD18 Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Integrin alphaXbeta2 (CR4) - Heterodimer: CD11c / CD18 Very late ... "HGNC Gene Group: C-type lectin domain containing". Retrieved 2019-08-30. Geijtenbeek TB, Gringhuis SI (July 2009). "Signalling ... Antigen Antigenicity Immunogen Superantigen Allergen Hapten Epitope Linear Conformational Mimotope Tumor antigen Antigen- ... ITGB3 Fibrinogen receptor Macrophage-1 antigen (CR3) - Heterodimer: CD11b / CD18 Fibronectin receptor: Integrin alpha2beta1 ...
This locus is very close to CD3 & CD56/NCAM genes. Some believe that there may be a functional significance of both this gene ... It was originally named theta (θ) antigen, then Thy-1 (THYmocyte differentiation antigen 1) due to its prior identification in ... It has been shown to interact with the leukocyte integrin Mac1 (CD11b/CD18) and may play a role in leukocyte homing and ... The antigen Thy-1 was the first T cell marker to be identified. Thy-1 was discovered by Reif and Allen in 1964 during a search ...
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.. *v ... "Entrez Gene: CDH8 cadherin 8, type 2".. *^ Pagnamenta AT, Khan H, Walker S, Gerrelli D, Wing K, Bonaglia MC, et al. (Jan 2011 ... Gene ontology. Molecular function. • calcium ion binding. • metal ion binding. • identical protein binding. • cytoskeletal ...
Intercellular adhesion molecule 5 is a protein that in humans is encoded by the ICAM5 gene. The protein encoded by this gene is ... and characterization of its interaction with the leukocyte integrin CD11a/CD18". Eur. J. Immunol. 30 (3): 810-8. doi:10.1002/ ... chromosomal localization of the human telencephalin and its distinctive interaction with lymphocyte function-associated antigen ... "Entrez Gene: ICAM5 intercellular adhesion molecule 5, telencephalin". Annaert, W G; Esselens C; Baert V; Boeve C; Snellings G; ...
The antigen is then transferred from CD23+ B cells to CD11c+ antigen presenting cells. The CD11c+ cells in turn present the ... "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". Immunity ... Lecoanet-Henchoz S, Gauchat JF, Aubry JP, Graber P, Life P, Paul-Eugene N, Ferrua B, Corbi AL, Dugas B, Plater-Zyberk C (Jul ... Antigens which enter the blood stream can be captured by antigen specific IgE antibodies. The IgE immune complexes that are ...
Ok blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ... 1997). "The Oka blood group antigen is a marker for the M6 leukocyte activation antigen, the human homolog of OX-47 antigen, ... 1998). "Characterization of the gene for human EMMPRIN, a tumor cell surface inducer of matrix metalloproteinases". Gene. 220 ( ... "Entrez Gene: BSG basigin (Ok blood group)".. *^ Kanekura T, Chen X, Kanzaki T (2002). "Basigin (CD147) is expressed on melanoma ...
1 2 Entrez Gene: ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide (неопр.). ... Tissue Antigens (англ.)русск. : journal. - 2007. - Vol. 68, no. 6. - P. 509-517. - DOI:10.1111/j.1399-0039.2006.00726.x. - PMID ... The Mammalian Gene Collection (MGC) (англ.) // Genome Res. (англ.)русск. : journal. - 2004. - Vol. 14, no. 10B. - P. 2121-2127 ... K-ATPase beta 3 subunit gene and pseudogene (англ.) // Mamm Genome (англ.)русск. : journal. - 1998. - March (vol. 9, no. 2). - ...
The papA gene, which is unique to sv. Newport, contributes to the strain's fitness in tomatoes, and has homologs in genomes of ... Serotyping is done by mixing cells with antibodies for a particular antigen. It can give some idea about risk. A 2014 study ... Salmonellae are also able to breach the intestinal barrier via phagocytosis and trafficking by CD18-positive immune cells, ... This second wave of iNTS possibly originated in the Congo Basin, and early in the event picked up a gene that made it resistant ...
1995). "CD23 regulates monocyte activation through a novel interaction with the adhesion molecules CD11b-CD18 and CD11c-CD18". ... "IgE-Mediated Enhancement of CD4+ T Cell Responses in Mice Requires Antigen Presentation by CD11c+ Cells and Not by B Cells". ... cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics 15 (1): 133-45. PMID 8432525. doi:10.1006/geno. ... tissue-specific and IL-4-specific regulation of gene expression". Cell 55 (4): 611-8. PMID 2972386. doi:10.1016/0092-8674(88) ...
In humans, the CD44 antigen is encoded by the CD44 gene on Chromosome 11.[5] CD44 has been referred to as HCAM (homing cell ... LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... Indian blood group system at BGMUT Blood Group Antigen Gene Mutation Database at NCBI, NIH ... Gene ontology. Molecular function. • collagen binding. • protein binding. • hyaluronic acid binding. • cytokine receptor ...
Plowman G. D., Brown J. P., Enns C. A., etal. Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3 ... Entrez Gene: MFI2 antigen p97 (melanoma associated) identified by monoclonal antibodies 133.2 and 96.5 (неопр.). ... Seligman P. A., Butler C. D., Massey E. J., etal. The p97 antigen is mapped to the q24-qter region of chromosome 3; the same ... Le Beau M. M., Diaz M. O., Plowman G. D., etal. Chromosomal sublocalization of the human p97 melanoma antigen. (англ.) // Hum. ...
CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... Hamann J, Hartmann E, van Lier RA (1996). „Structure of the human CD97 gene: exon shuffling has generated a new type of seven- ... 2001). „Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens. 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ...
Barnett T, Zimmermann W (1990). "Workshop report: proposed nomenclature for the carcinoembryonic antigen (CEA) gene family". ... 1988). "Chromosomal localization of the carcinoembryonic antigen gene family and differential expression in various tumors". ... Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) also known as CD66e (Cluster of Differentiation 66e), is a ... "Cloning of the complete gene for carcinoembryonic antigen: analysis of its promoter indicates a region conveying cell type- ...
1992). „Cloning and structural analysis of the human c-kit gene". Oncogene. 7 (7): 1259-66. PMID 1377810.. CS1 одржавање: ... 1991). „Expression of the YB5.B8 antigen (c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID ... CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... Spritz RA, Droetto S, Fukushima Y (1992). „Deletion of the KIT and PDGFRA genes in a patient with piebaldism". Am. J. Med. ...
Gene ontology. Molecular function. • antigen binding. • transmembrane signaling receptor activity. • MHC class II protein ... "Entrez Gene: LAG3 lymphocyte-activation gene 3".. *^ a b c Triebel F, Jitsukawa S, Baixeras E, Roman-Roman S, Genevee C, Viegas ... Lymphocyte-activation gene 3, also known as LAG-3, is a protein which in humans is encoded by the LAG3 gene.[5] LAG3, which was ... Gene[edit]. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all ...
... antigens, cd18 MeSH D12.776.543.750.705.408.200.500 - antigens, cd29 MeSH D12.776.543.750.705.408.200.750 - integrin beta3 MeSH ... calcitonin gene-related peptide MeSH D12.776.543.750.720.600.270 - receptors, cholecystokinin MeSH D12.776.543.750.720.600. ... antigen, b-cell MeSH D12.776.543.750.705.816.821.500 - antigens, cd79 MeSH D12.776.543.750.705.816.824 - receptors, antigen, t- ... antigens, cd22 MeSH D12.776.543.550.200.124 - antigens, cd24 MeSH D12.776.543.550.200.131 - antigens, cd31 MeSH D12.776.543.550 ...
CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... 2000). "Characterization of a new member of the TNF family expressed on antigen presenting cells.". Biol. Chem. 380 (12): 1443- ... "Entrez Gene: tumor necrosis factor (ligand) superfamily". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView& ... "BLyS receptor signatures resolve homeostatically independent compartments among naïve and antigen-experienced B cells.". Semin ...
I. Partial characterization of soluble Ki-1 antigen and detection of the antigen in cell culture supernatants and in serum by ... "Entrez Gene: TNFRSF8 tumor necrosis factor receptor superfamily, member 8".. *^ Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL ( ... "Genes & Development. 11 (21): 2810-21. doi:10.1101/gad.11.21.2810. PMC 316646. PMID 9353251.. ... Gene ontology. Molecular function. • transmembrane signaling receptor activity. • tumor necrosis factor-activated receptor ...
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... Gene and regulation[edit]. P-selectin is located on chromosome 1q21-q24, spans , 50 kb and contains 17 exons in humans.[7] P- ... Gene ontology. Molecular function. • heparin binding. • oligosaccharide binding. • lipopolysaccharide binding. • calcium- ... P-selectin is a protein that in humans is encoded by the SELP gene.[5] ...
Click on genes, proteins and metabolites below to link to respective articles.[§ 1] [[File:. ... The protein also carries the Jr(a) antigen, which defines the Junior blood group system.[9] ... Click on genes, proteins and metabolites below to link to respective articles. [§ 1] [[File:. ... ATP-binding cassette super-family G member 2 is a protein that in humans is encoded by the ABCG2 gene.[5][6] ABCG2 has also ...
van Rhenen A., van Dongen G. A., Kelder A., et al. The novel AML stem cell associated antigen CLL-1 aids in discrimination ... Entrez Gene: CLEC12A C-type lectin domain family 12, member A (неопр.). ...
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... Gene ontology. Molecular function. • calcium ion binding. • protein binding. • ankyrin binding. • gamma-catenin binding. • beta ... "Entrez Gene: CDH1 cadherin 1, type 1, E-cadherin (epithelial)".. *^ Fleming TP, Papenbrock T, Fesenko I, Hausen P, Sheth B ( ... Berx G, Becker KF, Höfler H, van Roy F (1998). "Mutations of the human E-cadherin (CDH1) gene". Human Mutation. 12 (4): 226-37 ...
CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... CD97 antigen je protein koji je kod ljudi kodiran CD97 genom.[1][2][3] ... Hamann J, Hartmann E, van Lier RA (Sep 1996). "Structure of the human CD97 gene: exon shuffling has generated a new type of ... 2001). "Tissue distribution of the human CD97 EGF-TM7 receptor". Tissue Antigens 57 (4): 325-31. PMID 11380941. doi:10.1034/j. ...
CD18 (Erlizumab) • CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) • CD23 (Lumiliksimab) • CD40 (Teneliksimab, Toralizumab) • ... Todd and Naylor, New chromosomal mapping assignments for argininosuccinate synthetase pseudogene 1, interferon-beta 3 gene, and ... ćelije bile identifikovane kao najpotentniji proizvođači tipa I interferona u odgovoru na antigen, i bile su nazvani prirodne ... Većina ali ne svi placentalni sisari kodiraju funkcionalne IFN-ε i IFN-κ gene. ...
"Entrez Gene: ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)".. *^ May, K. E.; Villar, J.; Kirtley, S.; ... This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.. *v ... Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene.[5] CD61 is a cluster of differentiation ... Gene ontology. Molecular function. • vascular endothelial growth factor receptor 2 binding. • fibronectin binding. • virus ...
Gene ontology. Molecular function. • dipeptidyl-peptidase activity. • receptor binding. • identical protein binding. • ... "Direct association of adenosine deaminase with a T cell activation antigen, CD26". Science. 261 (5120): 466-9. doi:10.1126/ ... The protein encoded by the DPP4 gene is an antigenic enzyme expressed on the surface of most cell types and is associated with ... is encoded by the DPP4 gene.[5] DPP4 is related to attractin, FAP, DPP8 and DPP9. The enzyme was rediscovered in 1974 by Schulz ...
They act by inhibiting genes that code for the cytokines Interleukin 1 (IL-1), IL-2, IL-3, IL-4, IL-5, IL-6, IL-8, and TNF- ... Past this period CD3 blocks the TCR-antigen binding and causes conformational change or the removal of the entire TCR3/CD3 ... The IL-2a (CD25, T-cell activation antigen, TAC) is expressed only by the already-activated T lymphocytes. Therefore, it is of ... By the use of recombinant gene technology, the mouse anti-Tac antibodies have been modified, leading to the presentation of two ...
Gene ontology. Molecular function. • cytokine activity. • CD40 receptor binding. • tumor necrosis factor receptor binding. • ... B cells can present antigens to a specialized group of helper T cells called TFH cells. If an activated TFH cell recognizes the ... Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help". Journal of Immunology. 149 (12): ... It binds to CD40 (protein) on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. In ...
antigen processing and presentation of peptide antigen via MHC class I. • antigen processing and presentation of exogenous ... OMIM: 173510 MGI: 107899 HomoloGene: 73871 ChEMBL: 1744526 GeneCards: CD36 Gene. Генная онтология. ... antigen processing and presentation of exogenous peptide antigen via MHC class I. • lipoprotein transport. • negative ... peptide antigen via MHC class I, TAP-dependent. • platelet degranulation. • MyD88-dependent toll-like receptor signaling ...
LFA-1 (CD11a+CD18). *Integrin alphaXbeta2 (CD11c+CD18). *Macrophage-1 antigen (CD11b+CD18) ... "Entrez Gene: VCAM1 vascular cell adhesion molecule 1".. *^ a b Barreiro O, Yanez-Mo M, Serrador JM, Montoya MC, Vicente- ... The VCAM-1 gene contains six or seven immunoglobulin domains, and is expressed on both large and small blood vessels only after ... It is alternatively spliced into two known RNA transcripts that encode different isoforms in humans.[6] The gene product is a ...
There are two isoforms of the protein, alpha and beta, each encoded by a different gene. In humans, both genes are located on ... In addition to aiding with cytotoxic T cell antigen interactions the CD8 co-receptor also plays a role in T cell signaling. The ... the CD8 co-receptor plays a role in T cell signaling and aiding with cytotoxic T cell antigen interactions. ... This affinity keeps the T cell receptor of the cytotoxic T cell and the target cell bound closely together during antigen- ...
Gene ontology. Molecular function. • receptor activity. • antigen binding. • virus receptor activity. • protein binding. • ... "Entrez Gene: SLAMF1 signaling lymphocytic activation molecule family member 1".. *^ Schwartz, Anton M.; Putlyaeva, Lidia V.; ... Signaling lymphocytic activation molecule 1 is a protein that in humans is encoded by the SLAMF1 gene.[5][6] Recently SLAMF1 ... "Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259-1268. doi:10.1016/j.bbagrm.2016.07.004.. ...
1993). "Human chemotaxis receptor genes cluster at 19q13.3-13.4. Characterization of the human C5a receptor gene.". ... CD18 • CD19 • CD20 • CD21 • CD22 • CD23 • CD24 • CD25 • CD26 • CD27 • CD28 • CD29 • CD30 • CD31 • CD32 (A, B) • CD33 • CD34 • ... 1996). "CD88 antibodies specifically bind to C5aR on dermal CD117+ and CD14+ cells and react with a desmosomal antigen in human ... 1992). "Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan ...
Structure of the human gene encoding the invariant gamma-chain of class II histocompatibility antigens (англ.) // Nucleic Acids ... CD74 (англ. HLA class II histocompatibility antigen gamma chain; HLA-DR antigens-associated invariant chain) - мембранный белок ... II histocompatibility antigen gamma chaingamma chain of class II antigensIiHLA-DR antigens-associated invariant chainIa antigen ... Riberdy J.M., Newcomb J.R., Surman M.J., Barbosa J.A., Cresswell P. HLA-DR molecules from an antigen-processing mutant cell ...
... su naspramni jedan drugom i formiraju antigen-vezujuće mesto, tako da molekul antitela sadrži dva antigen-vezujuća mesta. ... CD18 (Erlizumab) • CD20 (Afutuzumab, Ocrelizumab, Pascolizumab) • CD23 (Lumiliksimab) • CD40 (Teneliksimab, Toralizumab) • ... "Phylogenetic diversification of immunoglobulin genes and the antibody repertoire". Mol. Biol. Evol. 10 (1): 60-72. PMID 8450761 ... Funkcionira uglavnom kao antigen receptor na B-limfocitima koji nisu bili izloženi antigenima. Dokazano je da aktivira bazofile ...
CD18; CELL-FREE SYSTEM; CELLS; CELLULAR STRESSES; CERAMIDE; CHEMOKINE GENE-EXPRESSION; CHROMOSOMAL LOCATION; CLOSTRIDIUM- ... ANTIGEN; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; ATHEROSCLEROTIC LESION; Autoimmune Diseases (Multiple Sclerosis, Rheumatoid ... GENE; GENE-EXPRESSION; Genetics; GROWTH-FACTOR-BETA; GTP-BINDING; GTP-BINDING PROTEINS; HIPPOCAMPAL SLICE; HIPPOCAMPAL SLICES; ... Uncovering novel gene function in TLR signalling using siRNA in, editor(s)ONeill, L.A.J and McCoy, C. , Toll-Like Receptors, ...
The CD18 integrin complexes bind CD54 (ICAM-1), CD102 (ICAM-2), CD50 (ICAM-3), iC3b, and fibrinogen. Heterodimers of CD18 with ... Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic ... CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an ... Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). ...
Gene Aliases: CD11B; CD11b/CD18; CR3; CR3A; F730045J24Rik; ITGAM; Ly-40; MAC-1; Mac-1a; MAC1; MAC1A; MO1A; SLEB6 ... Protein Aliases: antigen CD11b (p170); CD11 antigen-like family member B; CD11b; CD11B (p170); cell surface glycoprotein MAC-1 ... CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). ... macrophage antigen alpha; macrophage antigen alpha polypeptide; Neutrophil adherence receptor; neutrophil adherence receptor ...
Gene Aliases: Cd11b; CD11b/CD18; CR3; CR3A; F730045J24Rik; Ly-40; Mac-1; Mac-1a; MAC1 ... M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood ... CD18). The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). ... CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, ...
CD11a, CD11c, and CD18 gene polymorphisms and susceptibility to Behçets disease in Koreans. Tissue Antigens. 2014 Oct. 84(4): ... MEFV gene is a probable susceptibility gene for Behcets disease. Scand J Rheumatol. 2005. 34(1):56-8. [Medline]. ... Skin hypersensitivity to streptococcal antigens and the induction of systemic symptoms by the antigens in Behçets disease--a ... Nishiyama M, Takahashi M, Manaka K, Suzuki S, Saito M, Nakae K. Microsatellite polymorphisms of the MICA gene among Japanese ...
Toxoplasma gondii soluble antigen induces a subset of lipopolysaccharide- inducible genes and tyrosine phosphoproteins in ... The role of CD11b/CD18 might be analogous to that of CD14, where CD11b/CD18 functions to bind Taxol (via CD18) and LPS, whereas ... CD11b/CD18 was also required. Mitigated induction of COX-2, IL-12 p35, and IL-12 p40 gene expression by CD11b/CD18-deficient ... and IL-12 p40 genes by both Taxol and LPS, whereas induction of TNF-α, IP-10, and ICSBP genes is CD11b/CD18-independent. ...
In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils ... In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18, mediates activation of TNF-alpha primed neutrophils ... Gene expression databases. Bgee dataBase for Gene Expression Evolution. More...Bgeei. ENSG00000204936, Expressed in blood and ... or inferences about a gene drawn from the phenotype of a mutation in a different gene.,/p> ,p>More information in the ,a href=" ...
LAD1 is caused by low expression of CD11 and CD18. CD18 is found on chromosome 21 and CD11 is found on chromosome 16. Leukocyte ... LAD is a genetic defect caused by autosomal recessive genes. The deficiency causes ineffective migration and phagocytosis for ... "Lymphocyte function-associated antigen 1 (LFA-1): a surface antigen distinct from Lyt-2,3 that participates in T lymphocyte- ... Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. LFA-1 plays a key ...
... identification of murine CD18 as a major taxol-binding protein and a role for Mac-1 in taxol-induced gene expression. J Immunol ... CD18" by people in this website by year, and whether "Antigens, CD18" was a major or minor topic of these publications. ... "Antigens, CD18" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... Below are the most recent publications written about "Antigens, CD18" by people in Profiles. ...
... leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion ... Gene Name:. ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) [ Homo sapiens ]; ITGB2 integrin, beta 2 ( ... antigen CD11C (p150), alpha polypeptide); LAD; CD18; MF17; MFI7; LCAMB; LFA-1; MAC-1; integrin beta-2; integrin beta chain, ... myeloid membrane antigen, alpha subunit; leukocyte surface antigen p150,95, alpha subunit; leukocyte adhesion glycoprotein p150 ...
CD11b Antigen / metabolism * CD18 Antigens / genetics * CD18 Antigens / immunology * CD18 Antigens / metabolism ... Gene Expression Regulation / genetics * Gene Expression Regulation / immunology * Granuloma, Respiratory Tract / chemically ... TDM-induced Mincle signaling on neutrophils increased cell adherence by enhancing F-actin polymerization and CD11b/CD18 surface ... coactivation of the Mincle and TLR2 pathways by TDM and Pam3CSK4 treatment synergistically induced CD11b/CD18 surface ...
CD18 (dog). CD18 is expressed by most leukocytes. Defects in the CD18 gene results in leukocyte adhesion deficiency. Although ... Factor VIII-related antigen. Factor VIII-realted antigen (vonWillebrand factor) is present in endothelial cells and in the ... The CD3 antigen is present on the cell membrane of normal T cells and is expressed in the majority of T-cell neoplasms. ... This antibody reacts with type specific as well as type-common antigens. It can be used to identify HXV-1 in the tissues of ...
Anti-CD18 antibody conjugated to PerCP [GRF1] validated for Flow Cyt and tested in Human. Immunogen corresponding to tissue, ... Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C antibody. *Leukocyte cell adhesion molecule CD18 antibody ... Entrez Gene: 3689 Human. *Omim: 600065 Human. *SwissProt: P05107 Human. *Unigene: 375957 Human ...
Mouse monoclonal CD18 antibody [MEM-48] conjugated to Biotin. Validated in Flow Cyt and tested in Human. Cited in 1 publication ... Ab28093 reacts with an epitope located in the region encoded by aa 534-546 in cysteine rich repeat 3 of the CD18 antigen. ... Entrez Gene: 3689 Human. *Omim: 600065 Human. *SwissProt: P05107 Human. *Unigene: 375957 Human ... Anti-CD18 antibody [MEM-48], prediluted (Allophycocyanin) (ab40914) *Anti-CD18 antibody [MEM-48] - Low endotoxin, Azide free ( ...
ITGB2 / CD18 (ITGB2 Antibody Abstract) Background Name/Gene ID: ITGB2. Family: Integrin. Synonyms: ITGB2, CD18 antigen, CD18, ... Antigen Integrin beta 2 (ITGB2) Antibodies show synonyms for this antigen * CD18 ... Gene ID 3689 Pathways NF-kappaB Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell ... A synthetic peptide corresponding to a sequence at the C-terminus of human CD18(732-748aa LREYRRFEKEKLKSQWN), identical to the ...
Clonality of the B-cell population could not be demonstrated using PCR testing for antigen receptor gene rearrangement. To the ... Weak to moderate CD18 positivity and E-cadherin positivity were also observed. ... Weak to moderate CD18 positivity and E-cadherin positivity were also observed. Clonality of the B-cell population could not be ... demonstrated using PCR testing for antigen receptor gene rearrangement. To the authors knowledge, this is the first reported ...
CD4+ T cell-associated pathophysiology critically depends on CD18 gene dose effects in a murine model of psoriasis. J Immunol. ... These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues ... Surface staining of CD18 in human peripheral blood with anti-CD18 (MEM-148) PE.. *BM4031S ... Surface staining of CD18 in human peripheral blood with anti-CD18 (MEM-148) PE.. *BM4031APC ...
Animals; Antigens, CD18/genetics/*metabolism; Antigens, CD44/genetics/metabolism; Calgranulin A/genetics/*metabolism; ... Calgranulin B/genetics/*metabolism; Cell Adhesion/*physiology; Gene Expression Regulation; Inflammation/chemically induced/ ...
ICAM-1 (ICAM1) Antigen Profile Protein Summary This gene encodes a cell surface glycoprotein which is typically expressed on ... It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. ...
... and leukocyte function-associated antigen-3. The CEA gene has a single amino acid substitution (aspartate substituting for ... which interacts with the CD11a/CD18 (leukocyte function-associated antigen-1/β2-integrin) complex; and CD58 (leukocyte function ... In this assay, antigen is added to PBMCs that must take up and present the antigen to T cells. Although the simplest antigen to ... Among the many tumor antigens described, the model antigen, carcinoembryonic antigen (CEA), is of particular interest because ...
Because the CD18 gene has been cloned and sequenced, this disorder is a potential candidate for gene therapy. As of 2010[update ... including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). The ... LAD1 is caused by mutations in the ITGB2 gene which are inherited autorecessively. This gene encodes CD18, a protein present in ... Candotti F, Fischer A. Gene therapy. In: Ochs HD, Smith CIE, Puck JM, eds. Primary immunodeficiency diseases: a molecular and ...
... leukocyte cell adhesion molecule CD18; leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C; cell surface adhesion ... Related Gene ITGB2 ITGB1 ITGB3 ITGB3BP ITGB5 ITGB7 ITGB1BP1 ITGB4 ITGB6 ITGB8 ... antigen CD18 (p95), lymphocyte function associated antigen 1; macrophage antigen 1 (mac 1) beta subunit) , MFI7; integrin beta- ... Antigen standard for integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 1 is a ...
Gene expression profiles of homozygous genotype-selected peripheral blood mononuclear cells (PBMCs) demonstrated that this ... Gene expression profiles of homozygous genotype-selected peripheral blood mononuclear cells (PBMCs) demonstrated that this ... leukocyte function antigen 1 encoded by ITGB2 gene) also known as CD11a/CD18 and its ligand, ICAM-1 (intercellular adhesion ... Genes with thick purple margin are DEG. (C) Quantitative RT-PCR validation of genes involved in the TWEAK/Fn14 pathway (NFKB1, ...
... related to the carcino-embryonic antigen (CEA) previously described on colon cancer cells. The CEA/CD66 gene group belongs to ... CD66b is thought to play a role in the regulation of the adhesive activity of CD11/CD18 via signal transduction in neutrophils ... The CD66 antigens were originally described as granulocyte-specific activation antigens, ... the immunoglobulin (Ig) gene superfamily. Among the CD66 cluster, CD66b (also known as CGM6) is a glycosyl-phosphatidylinositol ...
ICAM1 gene is mapped to human chromosome 19. In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer ... antigens. Intercellular adhesion molecule-1 (ICAM-1) is an integral membrane protein, a member of the immunoglobulin ... CD11a/CD18 (Leu-CAMa, LFA-1) and its ligand CD54 (ICAM-1). ... Antigen Retrieval. Device: Incubator. Buffer/pH value: IHC-Tek ...
These include several genes encoded in the human leukocyte antigen (HLA) as well as genes encoding protein tyrosine phosphatase ... complement related genes, CD18. , IL-10. , CD226. as well as the Fc gamma receptors; FCGR2A. , FCGR3B. (for both copy number ... Many of the candidate genes identified as being over represented in vasculitis patients are associated with genes which encode ... These specialised antigen presenting cells (APCs) recognise antigens through pattern-recognition receptors and co-ordinate the ...
This study reports the sequencing of the wild boar beta2-integrin CD11a and CD18 cDNAs. Predicted CD11a and CD18 subunits share ... Besides these strong overall similarities, wild boar and domestic pig LFA-1 differ by 2 (CD18) and 1 or 3 (CD11a) substitutions ... CD11a/CD18, alphaLbeta2), expressed on all leukocytes, is essential for many adhesive functions of the immune system. ... with a larger interspecies conservation for the CD18 than the CD11a. ...
CD18); expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1 ... Entrez Gene: 16p11.2 Specificity The mouse monoclonal antibody CBRM1/5 recognizes an activation-dependent epitope on CD11b (Mac ... categories: CD and Related Antigens (Human). Mouse Monoclonal to CD11b activation epitope. CBRM1/5 (IgG1). Technical ... CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating ...
DNA sequence analysis of 1.7 kilobases of the 5 flanking sequence of the CD11b gene indicated the absence of a "CAAT" or "TATA ... The CD11b (or macrophage-1 antigen; MAC-1) subunit of the leukocyte integrin family forms a noncovalently associated ... heterodimeric structure with the CD18 (beta) subunit on the surface of human granulocytes and monocyte/macrophages, where it ... To study the regulation of CD11b expression, a genomic clone corresponding to the 5 region of the CD11b gene was isolated from ...
CD18]]) * [[Integrin alphaXbeta2]] ([[CD11c]]+[[CD18]]) * [[Macrophage-1 antigen]] ([[CD11b]]+[[CD18]]) * [[VLA-4]] ([[CD49d ... gene),CDH1]] * [[CDH2]] * [[CDH3 (gene),CDH3]] , group2 = [[Desmosome,Desmosomal]] , list2 = * [[Desmoglein]] ([[Desmoglein-1, ... Carcinoembryonic antigen]] * [[CD22]] * [[CD24]] * [[CD44]] * [[CD146]] * [[CD164]] , belowstyle = padding:0; ;See also : [[ ...
  • CD18 associates non-covalently with CD11a, CD11b, and CD11c to form LFA-1, Mac-1, and gp150/95, respectively and plays an important role in leukocytes adhesion. (miltenyibiotec.com)
  • CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18). (thermofisher.com)
  • The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3). (thermofisher.com)
  • CD11b non-covalently associates with CD18 to form alphaMbeta2 integrin (Mac-1) and binds to CD54 (ICAM-1), C3bi, and fibrinogen. (thermofisher.com)
  • M1/70 is also cross-reactive to human CD11b, and can be used for the detection of this antigen on human peripheral blood monocytes, granulocytes, and a subset of NK cells. (thermofisher.com)
  • Recent reports indicate that three membrane-associated proteins, CD14, CD11b/CD18, and Toll-like receptor (TLR) 4, may serve as LPS recognition and/or signaling receptors in murine macrophages. (jimmunol.org)
  • In contrast, for optimal induction of COX-2, IL-12 p35, and IL-12 p40 genes by low concentrations of LPS or by all concentrations of Taxol, CD11b/CD18 was also required. (jimmunol.org)
  • Mitigated induction of COX-2, IL-12 p35, and IL-12 p40 gene expression by CD11b/CD18-deficient macrophages correlated with a marked inhibition of NF-κB nuclear translocation and mitogen-activated protein kinase (MAPK) activation in response to Taxol and of NF-κB nuclear translocation in response to LPS. (jimmunol.org)
  • These findings suggest that for expression of a full repertoire of LPS-/Taxol-inducible genes, CD14, TLR4, and CD11b/CD18 must be coordinately engaged to deliver optimal signaling to the macrophage. (jimmunol.org)
  • TDM-induced Mincle signaling on neutrophils increased cell adherence by enhancing F-actin polymerization and CD11b/CD18 surface expression. (nih.gov)
  • Moreover, coactivation of the Mincle and TLR2 pathways by TDM and Pam3CSK4 treatment synergistically induced CD11b/CD18 surface expression, reactive oxygen species, and TNFα production by neutrophils. (nih.gov)
  • 1. Gao JX, Issekutz AC: Mac-1 (CD11b/CD18) is the predominant beta 2 (CD18) integrin mediating human neutrophil migration through synovial and dermal fibroblast barriers. (acris-antibodies.com)
  • 2. Shang XZ, Issekutz AC: Contribution of CD11a/CD18, CD11b/CD18, ICAM-1 (CD54) and -2 (CD102) to human monocyte migration through endothelium and connective tissue fibroblast barriers. (acris-antibodies.com)
  • expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. (exbio.cz)
  • CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. (exbio.cz)
  • CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component. (exbio.cz)
  • Diamond MS, Springer TA: A subpopulation of Mac-1 (CD11b/CD18) molecules mediates neutrophil adhesion to ICAM-1 and fibrinogen. (exbio.cz)
  • Fagerholm SC, Varis M, Stefanidakis M, Hilden TJ, Gahmberg CG: alpha-Chain phosphorylation of the human leukocyte CD11b/CD18 (Mac-1) integrin is pivotal for integrin activation to bind ICAMs and leukocyte extravasation. (exbio.cz)
  • To study the regulation of CD11b expression, a genomic clone corresponding to the 5' region of the CD11b gene was isolated from a human chromosome 16 library. (pnas.org)
  • 14,15,25,26 CD11a/CD18 (lymphocyte function-associated antigen 1 [LFA-1]) and CD11b/CD18 (Mac-1) are the most important members of the β 2 integrin family. (asahq.org)
  • It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. (abbkine.com)
  • CD11a/CD18 is a lymphocyte function-associated antigen-1, and CD11b/CD18 is a macrophage antigen-1. (antibodybeyond.com)
  • Chinese hamster ovary (CHO) fibroblast cell lines expressing the CD11a/CD18 or CD11b/CD18 antigen were engineered by gene transfection. (antibodybeyond.com)
  • CD11b/CD18 and CD11c/CD18 are more restricted antigens normally expressed on monocytes, macrophages, PMN and natural killer cells. (antibodybeyond.com)
  • Indirect immunoperoxidase staining patterns indicated that intratracheal challenge with beads activated BAL cells and upregulated expression of CD11b, ICAM-1, and CD18 antigenic markers on macrophages and neutrophils when compared with BAL cells from saline controls. (antibodybeyond.com)
  • Immunohistochemical staining also confirmed the presence of CD11b on activated macrophages and neutrophils around the beads and of the ICAM-1 antigen in the lung parenchyma of bead challenged mice. (antibodybeyond.com)
  • CD18, integrin b2 subunit, forms heterodimers with four types of CD11 molecule to constitute leukocyte (b2) integrins: aLb2 (CD11a/CD18, LFA-1), aMb2 (CD11b/CD18, Mac-1, CR3), aXb2 (CD11c/CD18) and aDb2 (CD11d/CD18). (novusbio.com)
  • CD18 is a 95KD cell surface glycoprotein that forms heterodimers with the integrin subunit alpha L (CD11a), alpha M (CD11b) or alpha X (CD11c) to produce integrins CD11a/CD18, CD11b/CD18 and CD11c/CD18 respectively. (abcam.cn)
  • The CD11/CD18 adhesion molecules consist of three heterodimers sharing a common beta subunit (CD18) with a distinct alpha subunit (CD11a, CD11b, CD11c). (fishersci.com)
  • CD18 forms heterodimers with four types of CD11 molecule to constitute leukocyte (beta2) integrins: alphaLbeta2 (CD11a/CD18, LFA-1), alphaMbeta2 (CD11b/CD18, Mac-1, CR3), alphaXbeta2 (CD11c/CD18) and alphaDbeta2 (CD11d/CD18). (fishersci.se)
  • It mediates the vascular adhesion and paracellular migration of leukocytes expressing activated LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18). (rndsystems.com)
  • Here, we asked for the importance of CD11b/CD18 also termed MAC-1 which is required for phagocytosis of opsonized A. fumigatus conidia by polymorphonuclear neutrophils (PMN) for control of pulmonary A. fumigatus infection. (frontiersin.org)
  • CD18 non-covalently associates with CD11a, CD11b or CD11c. (biolegend.com)
  • 4,5 Lovastatin affects the β2 integrin family of proteins by preventing the formation of CD11b/CD18 heterodimers on monocytes. (ahajournals.org)
  • NCBI/Uniprot data below describe general gene information for CD11b . (mybiosource.com)
  • The most predominant beta 2-integrin lymphocyte function-associated antigen-1 (LFA-1, CD11a/CD18, alpha L beta 2), expressed on all leukocytes, is essential for many adhesive functions of the immune system. (biomedcentral.com)
  • This study reports the sequencing of the wild boar beta 2-integrin CD11a and CD18 cDNAs. (biomedcentral.com)
  • Predicted CD11a and CD18 subunits share all the main structural characteristics of their mammalian homologues, with a larger interspecies conservation for the CD18 than the CD11a. (biomedcentral.com)
  • Besides these strong overall similarities, wild boar and domestic pig LFA-1 differ by 2 (CD18) and 1 or 3 (CD11a) substitutions, of which one is located in the crucial I-domain (CD11a, E168D). (biomedcentral.com)
  • In humans, lymphocyte adhesion to cells is mediated by the protein heterodimer CD11a/CD18 (Leu-CAMa, LFA-1) and its ligand CD54 (ICAM-1). (ihcworld.com)
  • Lymphocyte function-associated antigen 1 is a heterodimer integrin CD11a (integrin alpha L, p189) and CD18 (integrin beta-2). (brainscape.com)
  • CD11a/CD18 are apparent on early progenitors of all myeloid and erythroid cells. (antibodybeyond.com)
  • The CD11a/CD18 mAbs found positive in the sheep were reactive with all the cell populations tested. (antibodybeyond.com)
  • Cell surface expression of CD11a and CD18, but not ICAM-1, was increased on HIV-infected, as compared to uninfected U937 and THP1 monocytoid cells. (antibodybeyond.com)
  • CD18 can combine with integrin molecules CD11a-c to form heterodimers at the cell surface, and these heterodimers are known to participate in the process of cell adhesion as well as cell-surface mediated signaling. (fishersci.se)
  • ß2 integrin receptors consist of an alpha subunit (CD11a-CD11d) and CD18 as the common beta subunit, and are differentially expressed by leukocytes. (frontiersin.org)
  • The protein is a ligand for lymphocyte-function associated (LFA) antigens and also a receptor for CD11a, b/CD18, fibrinogen, human rhinovirus and Plasmodium falciparum-infected erythrocytes. (bizpr.co.uk)
  • CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)
  • 2 In addition, fluvastatin inhibits the expression of lymphocyte function-associated antigen (CD11a/CD18) and ICAM-1 on human monocytic cell lines. (ahajournals.org)
  • Intercellular adhesion molecules (ICAMs) are type I transmem brane glycoproteins, which contain 2-9 immunoglobulin-like C2-type domains, and bind to lymphocyte function- associated antigen-1 (LFA-1, also known as a L/ ß 2 or CD11a/CD18). (acris-antibodies.com)
  • The mean fluorescence of CD18 on lymphocytes and CD11c on monocytes of HIV-1-infected subjects was significantly higher than for the control group (P = .008 and .014, respectively). (antibodybeyond.com)
  • CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. (fishersci.com)
  • CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. (fishersci.com)
  • The CD11c/CD18 complex is expressed on dendritic cells (highly expressed on type 1 myeloid DCs), monocytes, macrophages, granulocytes, NK cells, and subsets of T and B cells. (fishersci.com)
  • Human Monoclonal ITGAX Primary Antibody for FACS, IHC (f) - ABIN302018 : Bullard, Hu, Adams, Schoeb, Barnum: p150/95 (CD11c/CD18) expression is required for the development of experimental autoimmune encephalomyelitis. (cheapguccisale.com)
  • Data suggest that blood neutrophils expressing CD11c antigen and EMR2 (show EMR2 Antibodies) protein be considered as potential biomarkers for sepsis and systemic inflammatory response syndrome (SIRS), respectively. (cheapguccisale.com)
  • LAD1 is caused by low expression of CD11 and CD18. (wikipedia.org)
  • CD18 is found on chromosome 21 and CD11 is found on chromosome 16. (wikipedia.org)
  • Patients with leukocyte adhesion molecule (CD11/CD18, beta 2 integrins) deficiency have structural defects in the common beta subunit (CD18), which prevent heterodimer formation and normal cell surface expression of these receptors, leading to life-threatening bacterial infections. (acris-antibodies.com)
  • CD66b is thought to play a role in the regulation of the adhesive activity of CD11/CD18 via signal transduction in neutrophils. (beckman.com)
  • beta-integrin (CD11/CD18) family plays an important role in inflammation via their regulatory effects on leukocyte adhesion, transmigration, and function. (antibodybeyond.com)
  • The CD11/CD18 integrins are transmembrane proteins. (antibodybeyond.com)
  • The anti-CD11/CD18 monoclonal antibodies (mAbs) submitted in the Second International Workshop on Ruminant Leukocyte Differentiation Antigens, were analysed for their reactivity with the ovine homologue of CD11/CD18. (antibodybeyond.com)
  • CD11 antigens appeared to be strongly expressed only on mature granulocytes, monocytes, and certain lymphocytes, but not significantly on myeloid committed precursor cells. (antibodybeyond.com)
  • In this report, we demonstrate that 9.3- lymphocytes express CD11, an antigen which is also present on monocytes and granulocytes. (antibodybeyond.com)
  • the number of alveolar macrophages (AM) expressing CD11/CD18 molecules is increased in smokers compared with nonsmokers and related to the superoxide anion (O2-) production of these cells. (antibodybeyond.com)
  • increased peripheral phagocyte CD11/CD18 expression is a feature of Tuberculosis (TB), which may contribute to the pathological processes involved. (antibodybeyond.com)
  • Using a novel method for the preparation of blood leucocytes for flow cytometry, we report increased expression of LeuCAMs (CD11/CD18) on peripheral blood leucocytes of 11 Caucasian and 10 Afro-Caribbean patients with sarcoidosis compared with age-, sex- and race-matched controls. (antibodybeyond.com)
  • As CD11/CD18 heterodimers pair intracellularly, LFA-1 is not expressed at the cell surface of leukocytes from LAD-1 patients. (biomedcentral.com)
  • In healthy individuals, stimulation of rolling leukocytes along endothelial cell lining induces a conformational change of CD11/CD18 heterodimers from a low to a high ligand-binding state, bringing cells to a halt. (biomedcentral.com)
  • CD11, along with CD18, form a heterodimer adhesion molecule. (fishersci.com)
  • This antibody recognizes the epitope exposed on free human CD18 chains unassociated with CD11 as well as on high-affinity state of LFA-1. (abcam.cn)
  • CD63, as other tetraspanins (CD9, CD81, CD82), has recently been reported as forming complexes with VLA-3 and phosphatidylinositol 4-kinase, with VLA-6, CD11/CD18 and tyrosine kinase. (mybeckman.pl)
  • Tan, S. M. (2012) The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties. (miltenyibiotec.com)
  • 9. Drbal K, Angelisova P, Cerny J, Hilgert I, Horejsi V: A novel anti-CD18 mAb recognizes an activation-related epitope and induces a high-affinity conformation in leukocyte integrins. (acris-antibodies.com)
  • 10. Drbal K, Angelisova P, Hilgert I, Cerny J, Novak P, Horejsi V: A proteolytically truncated form of free CD18, the common chain of leukocyte integrins, as a novel marker of activated myeloid cells. (acris-antibodies.com)
  • These receptors are essential for an effective immune system as observed in repeated infections associated with the lymphocyte adhesion deficiency (LAD) type I syndrome, a disease due to mutations in the β 2 (CD18) subunit gene leading to the lack of functional β 2 integrins on the membrane surface of leukocytes [ 12 - 14 ]. (biomedcentral.com)
  • Further, pre-incubation of PAMs with a CD18-blocking antibody prior to ApxI stimulation significantly reduced the activation of p38 and JNK, and subsequent expression of IL-1β, IL-8 or TNF-α gene, indicating a pivotal role of β2 integrins in the ApxI-mediated effect. (biomedcentral.com)
  • Collectively, this study demonstrated ApxI induces gene expression of IL-1β, IL-8 and TNF-α in PAMs that involves β2 integrins and downstream MAPKs. (biomedcentral.com)
  • Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)
  • In this study, we analyzed IL-2-activated polyclonal natural killer (NK) cells derived from 2 patients affected by leukocyte adhesion deficiency type I (LAD1), an immunodeficiency characterized by mutations of the gene coding for CD18, the beta subunit shared by major leukocyte integrins. (prednisone2020.site)
  • Clonality of the B-cell population could not be demonstrated using PCR testing for antigen receptor gene rearrangement. (tennessee.edu)
  • This gene encodes CD18, a protein present in several cell surface receptor complexes found on white blood cells, including lymphocyte function-associated antigen 1 (LFA-1), complement receptor 3 (CR-3), and complement receptor 4 (CR-4). (wikipedia.org)
  • Antigen standard for integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) (ITGB2), transcript variant 1 is a lysate prepared from HEK293T cells transiently transfected with a TrueORF gene-carrying pCMV plasmid and then lysed in RIPA Buffer. (creativebiomart.net)
  • In several tumors, we observed myeloid characteristics (myeloperoxidase [MPO] staining) together with rearrangements of the germinal configuration of the T-cell receptor β (TCRβ) gene and/or of the immunoglobulin heavy chain gene, specific for T-cell and B-cell lineages, respectively. (asm.org)
  • Clone REA412 recognizes the human lymphotoxin beta receptor (LT-ßR) antigen, a 47 kDa single-pass type I membrane protein which is also known as tumor necrosis factor receptor superfamily member 3 (TNF-RIII). (miltenyibiotec.com)
  • On the other hand, trisomy 4 was found in three cases (3.2%) and these cells showed low expressions of CD19 ( P =0.06) and IL-7 receptor ( P =0.05), and high expressions of CD33 ( P =0.13), CD18 ( P =0.03), and CD56 ( P =0.03) when compared to t(8;21) AML without additional karyotypes. (nature.com)
  • The Mac-1 antigen is a macrophage differentiation antigen associated with type three complement receptor (CR3). (atcc.org)
  • Effect of Cryopreservation on Autologous Chimeric Antigen Receptor T Cell Characteristics. (nih.gov)
  • Chimeric antigen receptor (CAR) T therapies for the treatment of hematologic malignancies: clinical perspective and significance. (nih.gov)
  • In the case of lymphoid proliferation, assessment of B or T cell antigen receptor rearrangement by polymerase chain reaction (PCR) provides valuable information pertaining to antigen receptor diversity in the lesion. (vin.com)
  • Similarly, B cells are identified by demonstration of the components of the B cell antigen receptor complex (specifically CD79a). (vin.com)
  • Intercellular Adhesion Molecule 1 (ICAM-1) is a protein encoded by the ICAM1 gene, which acts as a receptor for major receptor group rhinovirus A-B capsid proteins and Coxsackievirus A21 capsid proteins. (bizpr.co.uk)
  • Our laboratory has examined this concept by evaluating two chimaeric antibodies of the same specificity (MOv18) but different isotype, an IgG1 and an IgE against the tumour antigen folate receptor α (FRα). (springer.com)
  • Therefore, the relative contribution of these proteins in the induction of cyclooxygenase 2 (COX-2), IL-12 p35, IL-12 p40, TNF-α, IFN-inducible protein (IP)-10, and IFN consensus sequence binding protein (ICSBP) genes in response to LPS or the LPS-mimetic, Taxol, was examined using macrophages derived from mice deficient for these membrane-associated proteins. (jimmunol.org)
  • Clone REA1226 recognizes the murine CD18 antigen, a 95 kDa glycoprotein also known as integrin beta-2 (ITGB2). (miltenyibiotec.com)
  • LAD1 is caused by mutations in the ITGB2 gene which are inherited autorecessively. (wikipedia.org)
  • Integrin beta-2 ( CD18 ) is a protein that in humans is encoded by the ITGB2 gene . (wikidoc.org)
  • This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. (cancerindex.org)
  • This will include a safety evaluation and preliminary assessment of the efficacy of hematopoietic gene therapy consisting of autologous CD34+ enriched cells transduced with a lentiviral vector carrying the ITGB2 gene in subjects with severe Leukocyte Adhesion Deficiency-I (LAD-I). Subjects will undergo mobilization and collection of peripheral blood hematopoietic stem cells (HSCs) with granulocyte-colony stimulating factor (G-CSF) and plerixafor or bone marrow harvest in select circumstances. (clinicaltrials.gov)
  • Once engrafted, it is anticipated that the gene-modified stem and progenitor cells will enable hematopoiesis, generating blood cells in which the integrated therapeutic gene (ITGB2) will be transcribed and translated to produce the therapeutic CD18 protein with a preferential high expression in mature myeloid cells. (clinicaltrials.gov)
  • Gene Therapy for Leukocyte Adhesion Deficiency-I (LAD-I): A Phase I Clinical Trial to Evaluate the Safety and Efficacy of the Infusion of Autologous Hematopoietic Stem Cells Transduced With a Lentiviral Vector Encoding the ITGB2 Gene. (clinicaltrials.gov)
  • CD34+ enriched hematopoietic stem cells from subjects with severe LAD-I transduced ex vivo with lentiviral vector carrying the ITGB2 gene, Chim-CD18-WPRE. (clinicaltrials.gov)
  • The antigen that bound to the monoclonal antibodies was identified as an important molecule in cellular recognition processes. (wikipedia.org)
  • The lack of CR3 interferes with chemotaxis, phagocytosis, and respiratory burst Flow cytometry with monoclonal antibodies is used to screen for deficiencies of CD18. (wikipedia.org)
  • Function = recognition of antigens through antibodies (= surface receptors). (verdec.com)
  • Precise cell identification can be achieved by the application of monoclonal antibodies (mAb) specific for leukocyte antigens to isolated cells, cell smears and tissue sections. (vin.com)
  • Fully human antibodies against a specific antigen can be prepared by administering the antigen to a transgenic animal which has been modified to produce such antibodies in response to antigenic challenge, but whose endogenous loci have been disabled. (freepatentsonline.com)
  • This recognises the human CD18 cell surface antigen, the integrin beta2 subunit. (novusbio.com)
  • This is present on both T and B cells and binds to ICAM-1 (CD54) on antigen presenting cells. (brainscape.com)
  • To determine the safety and immunologic and clinical efficacy of a dendritic cell vaccine modified to hyperexpress costimulatory molecules and tumor antigen. (aacrjournals.org)
  • In this phase I study, we administered one or two cycles of four triweekly s.c./intradermal injections of ex vivo generated dendritic cells modified with a recombinant fowlpox vector encoding carcinoembryonic antigen (CEA) and a triad of costimulatory molecules [rF-CEA(6D)-TRICOM]. (aacrjournals.org)
  • Because of the crucial role of dendritic cells in adaptive immunity and their potent activity in animal tumor models, numerous pilot studies have evaluated immunotherapy with dendritic cells loaded with antigen in the form of peptide, protein, DNA, mRNA, tumor lysates, tumor fusions, and viral vectors ( 1 ). (aacrjournals.org)
  • To overcome these limitations, we have been studying strategies for genetic modification of dendritic cells with viral vectors encoding full length tumor antigens and costimulatory molecules. (aacrjournals.org)
  • Viral gene delivery into dendritic cells has been successfully done using poxviruses, herpes simplex, adenovirus, retrovirus, lentivirus, and adeno-associated virus (reviewed in ref. 8 ). (aacrjournals.org)
  • Interferon alpha is coded by 13 genes on chromosome 9, and is strongly produced by plasmacytoid dendritic cells. (brainscape.com)
  • In vivo dendritic cell ablation, along with CD20 immunotherapy, revealed that optimal antigen-specific CD4 + T cell priming required both B cells and dendritic cells. (pnas.org)
  • Dendritic cells are the most potent antigen presenting cells. (vin.com)
  • Proteome Based Construction of the Lymphocyte Function-Associated Antigen 1 (LFA-1) Interactome in Human Dendritic Cells. (sinobiological.com)
  • The interaction of DC-SIGN with ICAM-3 establishes initial contact between dendritic cells and resting T-cells during antigen presentation. (acris-antibodies.com)
  • Tissue inflammation induces rapid mobilization of antigen-charged dendritic cells (DCs), which migrate to draining lymph nodes via afferent lymphatics to elicit the immune response. (ox.ac.uk)
  • CD63 antigen, present in azurophilic granules of non-stimulated neutrophils, is strongly expressed on the surface of neutrophils after activation. (mybeckman.pl)
  • A correlation existed between the early inflammatory granulomas in spleen (containing macrophages with internalized L. garvieae ) and up-regulated gene sets, which defined the presence of macrophages and neutrophils. (biomedcentral.com)
  • Lymphocyte function-associated antigen 1 (LFA-1) is an integrin found on lymphocytes and other leukocytes. (wikipedia.org)
  • i) interaction between lymphocytes, (ii) interaction between T-cells and antigen presenting cells, (iii) adhesion of naïve lymphocytes to post-capillary high endothelial venules of secondary lymphoid tissues, (iv) adhesion of leukocytes to activated endothelium at sites of inflammation for extravasation, (v) control of cell differentiation and proliferation, and (vi) antibody-dependent killing by natural killer cells and granulocytes. (biomedcentral.com)
  • The regulation of lymphocyte migration can be clarified by selectively inhibiting or augmenting the function of these cell adhesion molecules.Cell migration to the site of antigen challenge is a process that involves not only lymphocytes and endothelial cells, but complex microhemodynamic forces as well. (dana-farber.org)
  • To study the effect of microhemodynamic forces on lymphocyte migration, we tracked migrating lymphocytes from the efferent lymph to the antigen-stimulated microcirculation. (dana-farber.org)
  • Heterodimers of CD18 with α subunits show different expression patterns on different leucocytes. (miltenyibiotec.com)
  • These data were complimented by the findings that cells derived from LPS-hyporesponsive C3H/HeJ and C57BL/10ScCR mice exhibit missense and deletion mutations, respectively, in the tlr4 gene ( 11 , 12 ). (jimmunol.org)
  • The CD3 antigen is present on the cell membrane of normal T cells and is expressed in the majority of T-cell neoplasms. (osu.edu)
  • Also referred to as MART1 (Melanoma Antigen Recognized by T cells). (osu.edu)
  • Factor VIII-realted antigen (vonWillebrand factor) is present in endothelial cells and in the cytoplasm of megakaryocytes. (osu.edu)
  • These include immune cell attachment to endothelial and antigen-presenting cells, cytotoxicity, and extravasation into tissues. (acris-antibodies.com)
  • A common goal of cancer vaccines in development is the activation of high levels of antigen-specific T cells. (aacrjournals.org)
  • The CD66 antigens were originally described as granulocyte-specific activation antigens, related to the carcino-embryonic antigen (CEA) previously described on colon cancer cells. (beckman.com)
  • MAC-1) subunit of the leukocyte integrin family forms a noncovalently associated heterodimeric structure with the CD18 (beta) subunit on the surface of human granulocytes and monocyte/macrophages, where it enables these myeloid cells to participate in a variety of adherence-related activities. (pnas.org)
  • Monocyte-Chemoattractant Protein 1 Gene Expression in Intestinal Epithelial Cells and Inflammatory Bowel Disease Mucosa," Gastroenterology 108(1):40-50 (1995). (patentgenius.com)
  • The expression of the CD18 integrin on Neutrophil (PMN) obtained from the pulmonary vascular lavage (PVL) of C. parvum-treated animals was increased compared with cells from control animals. (antibodybeyond.com)
  • DC are professional antigen-presenting cells that sample the environment at sites of pathogen entry. (biomedcentral.com)
  • During antigen presentation, ICAM-1 expressed by DC binds to T cells via leukocyte function-associated molecule-1 (LFA-1). (biomedcentral.com)
  • CAR T Cells Targeting B7-H3, a Pan-Cancer Antigen, Demonstrate Potent Preclinical Activity Against Pediatric Solid Tumors and Brain Tumors. (nih.gov)
  • Tetraspanins CD9 and CD81 are molecular partners of trimeric FcsRI on human antigen-presenting cells. (thefreedictionary.com)
  • Very few leukocyte antigens are expressed only by a single lineage of cells. (vin.com)
  • Hence, DC in humans and dogs are best defined by their abundant expression of molecules essential to their function as antigen presenting cells. (vin.com)
  • In these sites they function as antigen processing and ultimately antigen presenting cells, which interact with T cells. (vin.com)
  • Migration of cutaneous DC (as veiled cells) via lymphatics to the paracortex of lymph nodes occurs following contact with antigen 6 . (vin.com)
  • The primary purpose of the Phase I portion of the study is to determine the safety profile and preliminary evidence of efficacy associated with infusion of autologous gene-corrected hematopoietic stem cells. (clinicaltrials.gov)
  • The gene-modified CD34+ cells will be then transplanted back into the subject. (clinicaltrials.gov)
  • CD18 and associated α chains function in adhesion and signaling in hematopoietic cells. (biolegend.com)
  • This selecting is additional strengthened with the observation that people detected protein mapping to over 50% of up to now 6200 gene versions in Kc167 cells that a proteins was detectable (Brunner Kc167 cells being a model organism for systems biology. (chenglilab.org)
  • Lymphocyte function-associated antigen 1 (LFA-1, αLβ2) is a leukocyte specific integrin that mediates firm arrest of leukocytes on the endothelium during migration and establishes cell-cell contacts such as the immunological synapse between DCs and T cells. (sinobiological.com)
  • In view of the important role played by phagocytosis in the activation of antigen presenting cells (APCs), the aim of the present work was to examine the interaction of TL2937 with porcine PPMPs focusing on phagocytosis. (biomedcentral.com)
  • Phagocytosis of microorganisms by antigen presenting cells (APCs) involves actin remodeling and the reorganization of the membrane that allows the appropriate formation of the phagocytic vesicle. (biomedcentral.com)
  • CD63 has been found to be identical to the ME491 antigen expressed by melanoma cells. (mybeckman.pl)
  • Human Monoclonal ITGAX Primary Antibody for FACS, IHC (f) - ABIN301988 : Angel, Lala, Chen, Edgar, Ostrovsky, Dunbar: CD14+ antigen-presenting cells in human dermis are less mature than their CD1a+ counterparts. (cheapguccisale.com)
  • This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. (genecards.org)
  • This antibody recognizes the antigen presenting on the cell surface membrane of tissue macrophages. (osu.edu)
  • The CD63 antigen, also known as lysosomal membrane associated glycoprotein 3 (LAMP3), is a member of the tetraspanin (TM4SF) family. (mybeckman.pl)
  • Both have been engineered to express tumor antigen, such as CEA, and have been tested in murine ( 10 ) and human ( 11 , 12 ) studies. (aacrjournals.org)
  • MCA2292B recognises the murine beta 2 integrin (CD18). (abcam.cn)
  • Flow cytometry analysis (surface staining) of CD18 in human peripheral blood with anti-CD18 (MEM-148) PE. (exbio.cz)
  • The antibody MEM-148 recognizes an extracellular epitope on CD18 which is essentially inaccessible in intact integrin molecules on resting leukocytes, but is exposed on high-affinity state of LFA-1 or on unassociated CD18. (exbio.cz)
  • 9,10 Studies on leukocyte function are also inconsistent, showing a severalfold increase in the leukocyte integrin-epitope CD18 after hemodilution of whole blood with dextran and HES, 11 whereas no changes in leukocyte adhesion molecules were reported in another comparative study examining lactated Ringer's solution, albumin, gelatin, and HES. (asahq.org)
  • Defects in the CD18 gene results in leukocyte adhesion deficiency. (osu.edu)
  • Defects in the CD18 gene are the cause of leukocyte adhesion deficiency type I (LAD1). (fishersci.se)
  • and the beta subunit, unique to leukocytes, is beta-2 or CD18. (wikipedia.org)
  • CD18 is expressed by most leukocytes. (osu.edu)
  • 8. Drbal K, Angelisova P, Cerny J, Pavlistova D, Cebecauer M, Novak P, Horejsi V: Human leukocytes contain a large pool of free forms of CD18. (acris-antibodies.com)
  • CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes. (novusbio.com)
  • Leukocytes expressing a functional CD18 will have the capability to arrest on endothelial surfaces and extravasate to infectious sites, enabling a competent antimicrobial response and reversing the clinical disorder. (clinicaltrials.gov)
  • CD18 is expressed on all leukocytes. (biolegend.com)
  • CD18 is expressed by all peripheral blood leukocytes. (chenglilab.org)
  • Integrin adhesion receptors transduce sigls that control complex cell functions which require the regulation of gene expression, such as proliferation, differentiation and survival. (acris-antibodies.com)
  • Cell lineage determination in the immune system has advanced since the inception of the 'cluster of differentiation' (CD) antigen system. (vin.com)
  • Mice leucocytes lacking CD18 or expressing dysfunctional CD18 are defective in chemotaxis, phagocytosis, and homotypic aggregation. (miltenyibiotec.com)
  • CD18 is expressed by the majority of leucocytes. (novusbio.com)
  • CD18 integrin beta 2 subunit is a 90 kDa type I transmembrane protein expressed on all leucocytes. (fishersci.se)
  • Left: (a) Natural derived OMVs vaccine formulas, including OMVs alone, OMVs combined with adjuvants, OMVs combined with bacterial antigens, and gold nanoparticles (AuNPs)‐loaded OMVs. (wiley.com)
  • Bacterial antigens are expressed as fusion proteins with outer membrane proteins located on the outer membrane surface of OMVs. (wiley.com)
  • Induction of the entire panel of genes in response to low concentrations of LPS or Taxol requires the participation of both CD14 and TLR4, whereas high concentrations of LPS or Taxol elicit the expression of a subset of LPS-inducible genes in the absence of CD14. (jimmunol.org)
  • severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. (novusbio.com)
  • Lack of proper β2 expression due to a deletion or mutation in the CD18 gene leads to Leukocyte Adhesion Deficiency type-1 (LAD-1). (biomedcentral.com)
  • Association and expression study of CD9 PLCz and COX-2 as candidate genes to improve boar sperm quality and fertility traits. (thefreedictionary.com)
  • Cell lineage is best determined by evaluation of the expression pattern of leukocyte antigens that are functionally important for a particular cell. (vin.com)
  • Absence of CD18 leads to leukocyte adhesion deficiency-1, severe reduction of CD18 expression leads to the development of a psoriasiform skin disease. (fishersci.se)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Heat-inactivation or pre-incubation of ApxI with a neutralizing antiserum attenuated ApxI bioactivity to induce cytokine gene expression. (biomedcentral.com)
  • This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
  • 1% expression of CD18). (medscape.com)
  • The expression of genes regulating the cytoskeleton was also affected, resulting in a block of CDC42 signaling. (aacrjournals.org)
  • Alterations in the expression of cytoskeletal regulatory genes and migration properties of BCP represent early events in the evolution of the disease, from the preleukemic phase to the clinical onset, and suggest new strategies for effective eradication of leukemia. (aacrjournals.org)
  • Analysis with a fluorescence activated cell sorter showed that the expression of 12.1 antigen changes during T cell maturation. (prednisone2020.site)
  • CD 45 is also referred to as Leucocyte Common Antigen. (osu.edu)
  • ICAM1 gene is mapped to human chromosome 19. (ihcworld.com)
  • Gene information is provided for human (Hs), mouse (Mm) and rat (Rn). (guidetopharmacology.org)
  • Applications Tested: This 118/A5 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low pH antigen retrieval. (fishersci.com)
  • Human CD18 antigen. (abcam.co.jp)
  • Isolation of single-copy human genes from a library of yeast artificial chromosomes", Science 244:1348-1351 (1989). (freepatentsonline.com)
  • CD18 is a 90-95 kD type I transmembrane protein also known as integrin β 2 subunit, LFA-1 β subunit, and β 2 integrin. (biolegend.com)
  • Functional loss of CD18-termed leukocyte-adhesion deficiency type 1 (LAD1)-results in an immunocompromised state characterized by frequent occurrence of severe infections. (frontiersin.org)
  • The CEA/CD66 gene group belongs to the immunoglobulin (Ig) gene superfamily. (beckman.com)
  • Immunoglobulin V.sub.h region genes of the mouse are organized in overlapping clusters" Eur. (freepatentsonline.com)
  • There are currently no images for Integrin beta 2/CD18 Antibody (NB200-610JF549). (novusbio.com)
  • The LFA-1 and Mac-1 antigens are composed of two chains or subunits, alpha and beta. (atcc.org)
  • The beta chain of LFA-1 (Leukocyte Function Associated antigen) is immunologically identical to the beta chain of the Mac-1 antigen. (atcc.org)
  • Mouse monoclonal to CD18.4A118 reacts with CD18, the 95 kDa beta chain component of leukocyte function associated antigen-1 (LFA-1). (chenglilab.org)