Annexin A2: A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.Annexin A1: Protein of the annexin family exhibiting lipid interaction and steroid-inducibility.Annexin A5: A protein of the annexin family isolated from human PLACENTA and other tissues. It inhibits cytosolic PHOSPHOLIPASE A2, and displays anticoagulant activity.Annexin A6: Protein of the annexin family with a probable role in exocytotic and endocytotic membrane events.Annexin A4: Protein of the annexin family originally isolated from the electric organ of the electric ray Torpedo marmorata. It has been found in a wide range of mammalian tissue where it is localized to the apical membrane of polarized EPITHELIAL CELLS.Annexin A7: An annexin family member that plays a role in MEMBRANE FUSION and signaling via VOLTAGE-DEPENDENT CALCIUM CHANNELS.Annexin A3: A protein of the annexin family that catalyzes the conversion of 1-D-inositol 1,2-cyclic phosphate and water to 1-D-myo-inositol 1-phosphate.Annexins: Family of calcium- and phospholipid-binding proteins which are structurally related and exhibit immunological cross-reactivity. Each member contains four homologous 70-kDa repeats. The annexins are differentially distributed in vertebrate tissues (and lower eukaryotes) and appear to be involved in MEMBRANE FUSION and SIGNAL TRANSDUCTION.S100 Proteins: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.Phosphatidylserines: Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a serine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and serine and 2 moles of fatty acids.Apoptosis: One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.Propidium: Quaternary ammonium analog of ethidium; an intercalating dye with a specific affinity to certain forms of DNA and, used as diiodide, to separate them in density gradients; also forms fluorescent complexes with cholinesterase which it inhibits.Calcium: A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.Phospholipids: Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.Calcium-Binding Proteins: Proteins to which calcium ions are bound. They can act as transport proteins, regulator proteins, or activator proteins. They typically contain EF HAND MOTIFS.Cell Membrane: The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.Protein Binding: The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.Cell Line, Tumor: A cell line derived from cultured tumor cells.Cells, Cultured: Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.Molecular Sequence Data: Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.Flow Cytometry: Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.Amino Acid Sequence: The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.Cell-Derived Microparticles: Extracellular vesicles generated by the shedding of CELL MEMBRANE blebs.Receptors, Formyl Peptide: A family of G-protein-coupled receptors that was originally identified by its ability to bind N-formyl peptides such as N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE. Since N-formyl peptides are found in MITOCHONDRIA and BACTERIA, this class of receptors is believed to play a role in mediating cellular responses to cellular damage and bacterial invasion. However, non-formylated peptide ligands have also been found for this receptor class.Recombinant Proteins: Proteins prepared by recombinant DNA technology.Caspase 3: A short pro-domain caspase that plays an effector role in APOPTOSIS. It is activated by INITIATOR CASPASES such as CASPASE 9. Isoforms of this protein exist due to multiple alternative splicing of its MESSENGER RNA.Blotting, Western: Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.Organotechnetium Compounds: Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.Cell Survival: The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.Cell Line: Established cell cultures that have the potential to propagate indefinitely.Caspases: A family of intracellular CYSTEINE ENDOPEPTIDASES that play a role in regulating INFLAMMATION and APOPTOSIS. They specifically cleave peptides at a CYSTEINE amino acid that follows an ASPARTIC ACID residue. Caspases are activated by proteolytic cleavage of a precursor form to yield large and small subunits that form the enzyme. Since the cleavage site within precursors matches the specificity of caspases, sequential activation of precursors by activated caspases can occur.Fluorescein-5-isothiocyanate: Fluorescent probe capable of being conjugated to tissue and proteins. It is used as a label in fluorescent antibody staining procedures as well as protein- and amino acid-binding techniques.In Situ Nick-End Labeling: An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in a template-independent manner, to the 3 prime OH ends of either single- or double-stranded DNA. The terminal deoxynucleotidyl transferase nick end labeling, or TUNEL, assay labels apoptosis on a single-cell level, making it more sensitive than agarose gel electrophoresis for analysis of DNA FRAGMENTATION.Fibrinolysin: A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.Binding Sites: The parts of a macromolecule that directly participate in its specific combination with another molecule.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Adrenal Insufficiency: Conditions in which the production of adrenal CORTICOSTEROIDS falls below the requirement of the body. Adrenal insufficiency can be caused by defects in the ADRENAL GLANDS, the PITUITARY GLAND, or the HYPOTHALAMUS.Search Engine: Software used to locate data or information stored in machine-readable form locally or at a distance such as an INTERNET site.Databases, Genetic: Databases devoted to knowledge about specific genes and gene products.Genome, Human: The complete genetic complement contained in the DNA of a set of CHROMOSOMES in a HUMAN. The length of the human genome is about 3 billion base pairs.Adipose Tissue: Specialized connective tissue composed of fat cells (ADIPOCYTES). It is the site of stored FATS, usually in the form of TRIGLYCERIDES. In mammals, there are two types of adipose tissue, the WHITE FAT and the BROWN FAT. Their relative distributions vary in different species with most adipose tissue being white.Obesity: A status with BODY WEIGHT that is grossly above the acceptable or desirable weight, usually due to accumulation of excess FATS in the body. The standards may vary with age, sex, genetic or cultural background. In the BODY MASS INDEX, a BMI greater than 30.0 kg/m2 is considered obese, and a BMI greater than 40.0 kg/m2 is considered morbidly obese (MORBID OBESITY).Adipocytes: Cells in the body that store FATS, usually in the form of TRIGLYCERIDES. WHITE ADIPOCYTES are the predominant type and found mostly in the abdominal cavity and subcutaneous tissue. BROWN ADIPOCYTES are thermogenic cells that can be found in newborns of some species and hibernating mammals.Oxygen Consumption: The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)Anoxia: Relatively complete absence of oxygen in one or more tissues.Carnivora: An order of MAMMALS, usually flesh eaters with appropriate dentition. Suborders include the terrestrial carnivores Fissipedia, and the aquatic carnivores PINNIPEDIA.Metagenome: A collective genome representative of the many organisms, primarily microorganisms, existing in a community.Carnivory: The consumption of animal flesh.Herbivory: The act of feeding on plants by animals.Diet: Regular course of eating and drinking adopted by a person or animal.Gluconeogenesis: Biosynthesis of GLUCOSE from nonhexose or non-carbohydrate precursors, such as LACTATE; PYRUVATE; ALANINE; and GLYCEROL.Dietary Carbohydrates: Carbohydrates present in food comprising digestible sugars and starches and indigestible cellulose and other dietary fibers. The former are the major source of energy. The sugars are in beet and cane sugar, fruits, honey, sweet corn, corn syrup, milk and milk products, etc.; the starches are in cereal grains, legumes (FABACEAE), tubers, etc. (From Claudio & Lagua, Nutrition and Diet Therapy Dictionary, 3d ed, p32, p277)
Examples of glucocorticoid-responsive genes include those that encode annexin A1, TSC22D3 (also known as GILZ), angiotensin- ... These target genes encode proteins such as cyclooxygenase, NO synthase, phospholipase A2, tumor necrosis factor, transforming ... The activated GR can then regulate gene expression via one of two pathways: Transactivation The first (direct) pathway is ... in feedback control of inflammatory gene expression and repression by dexamethasone". The Journal of Biological Chemistry. 289 ...
... , also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the ... Annexin A1 has also been shown to be associated with treatment resistance. ARID1A loss activates annexin A1 expression, which ... annexin A1 is promptly mobilized to the cell surface and secreted. Annexin A1 promotes neutrophil detachment and apoptosis, and ... The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia. ANXA1 protein expression is specific to hairy cell ...
1992). "Annexin II inhibits calcium-dependent phospholipase A1 and lysophospholipase but not triacyl glycerol lipase activities ... Acyl-protein thioesterase 1 is an enzyme that in humans is encoded by the LYPLA1 gene. Lysophospholipases are enzymes that act ... There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. GRCh38 ... "Entrez Gene: LYPLA1 lysophospholipase I". Wang A, Dennis EA (1999). "Mammalian lysophospholipases". Biochim. Biophys. Acta. ...
However some annexins (Annexin A1, Annexin A2, and Annexin A5) have also been found outside the cellular environment, for ... Annexin is also known as lipocortin. Lipocortins suppress phospholipase A2. Increased expression of the gene coding for annexin ... Annexin, type I InterPro: IPR002388 Annexin, type II InterPro: IPR002389 Annexin, type III InterPro: IPR002390 Annexin, type IV ... In addition to annexin A-II, annexin A-XI has also been shown to organize cell membrane properties. Annexin A-XI is believed to ...
"MicroRNA-196a targets annexin A1: A microRNA-mediated mechanism of annexin A1 downregulation in cancers". Oncogene. 27 (52): ... andJUNare dysregulated among other genes by miRNAs in malignant mesothelioma-A miRNA microarray analysis". Genes, Chromosomes ... MicroRNAs function to regulate the expression levels of other genes by several mechanisms. MicroRNA 1. 2. 3. 4. 5. 6. 7. 8. 9. ... "Differential miRNA expression and their target genes between NGX6-positive and negative colon cancer cells". Molecular and ...
Biaoxue R, Xiling J, Shuanying Y, Wei Z, Xiguang C, Jinsui W, Min Z (Aug 2012). "Upregulation of Hsp90-beta and annexin A1 ... "HUGO gene nomenclature committee". HUGO gene nomenclature committee. Retrieved 2 April 2015. Lamphere L, Fiore F, Xu X, ... Wu JM, Xiao L, Cheng XK, Cui LX, Wu NH, Shen YF (Dec 2003). "PKC epsilon is a unique regulator for hsp90 beta gene in heat ... "Entrez Gene: HSP90AB1 Heat shock protein 90kDa alpha (cytosolic), class B member 1". Lindquist S (June 1986). "The heat-shock ...
2006). "In vitro and in vivo studies on CCR10 regulation by Annexin A1". FEBS Lett. 580 (5): 1431-8. doi:10.1016/j.febslet. ... "Entrez Gene: CCR10 chemokine (C-C motif) receptor 10". Balkwill F (July 2004). "Cancer and the chemokine network". Nat. Rev. ... C-C chemokine receptor type 10 is a protein that in humans is encoded by the CCR10 gene. Chemokines are a group of small ( ... 2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome ...
... a genetic disorder Annexin A1, a human protein Outer membrane phospholipase A1, a bacterial protein receptors α-1-Adrenoceptor ... member A1 UDP glucuronosyltransferase 1 family, polypeptide A1 Urea Transporter A1 a gene found in the maize encoding for the ... member A1 Replication protein A1 S100 calcium binding protein A1 Sec61 alpha 1 Serum amyloid A1 Solute carrier family 35 (CMP- ... member A1 Aldo-keto reductase family 1, member A1 Alpha-1-microglobulin/bikunin precursor Apolipoprotein A1 and ApoA-1 Milano ...
Annexin A1 (also termed ANXA1 and lipocortin 1) and its N-terminal peptides (Ac2-26 and Ac9-25). At low concentrations, these ... gene. This gene encodes a G protein-coupled receptor cell surface protein that binds and is activated by N-Formylmethionine- ... whose gene is located at chromosome 12p13; C3a also acts through C5L2. Mouse formyl peptide receptor genes localize to ... Genes and Immunity. 4 (1): 22-9. doi:10.1038/sj.gene.6363900. PMID 12595898. Polakis PG, Uhing RJ, Snyderman R (Apr 1988). "The ...
Lennon NJ, Kho A, Bacskai BJ, Perlmutter SL, Hyman BT, Brown RH (2003). "Dysferlin interacts with annexins A1 and A2 and ... Dysferlin also known as dystrophy-associated fer-1-like protein is a protein that in humans is encoded by the DYSF gene. ... Bashir R, Strachan T, Keers S, Stephenson A, Mahjneh I, Marconi G, Nashef L, Bushby KM (1994). "A gene for autosomal recessive ... "Entrez Gene: DYSF dysferlin, limb girdle muscular dystrophy 2B (autosomal recessive)". Leiden University Medical Center, Center ...
... annexin a1 MeSH D12.776.157.125.050.060 -- annexin a2 MeSH D12.776.157.125.050.070 -- Annexin A3 MeSH D12.776.157.125.050.080 ... interferon-stimulated gene factor 3, gamma subunit MeSH D12.776.157.057.061.500 -- interferon-stimulated gene factor 3, alpha ... annexin a4 MeSH D12.776.157.125.050.100 -- annexin a5 MeSH D12.776.157.125.050.110 -- annexin a6 MeSH D12.776.157.125.050.120 ... annexin a7 MeSH D12.722.214.171.1242.249 -- calmodulin MeSH D12.7126.96.36.1992.311 -- calnexin MeSH D12.7188.8.131.522.374 -- ...
... also known as annexin II is a protein that in humans is encoded by the ANXA2 gene. Annexin 2 is involved in diverse ... Bohn E, Gerke V, Kresse H, Löffler BM, Kunze H (Jan 1992). "Annexin II inhibits calcium-dependent phospholipase A1 and ... "Entrez Gene: ANXA2 annexin A2". Kling T, Ferrarese R, Ó hAilín D, Johansson P, Heiland DH, Dai F, Vasilikos I, Weyerbrock A, ... Annexin II is a pleiotropic protein meaning that its function is dependent on place and time in the body. The ANXA2 gene, ...
Ac2-26 and Ac9-25 of Annexin A1 (ANXA1 or lipocortin 1), which at high concentrations fully stimulate neutrophil functions but ... The human FPR2 gene encodes the 351 amino acid receptor, FPR2, within an intronless open reading frame. It forms a cluster with ... The human receptor protein is encoded by the FPR2 gene and is activated to regulate cell function by binding any one of a wide ... Perez HD, Holmes R, Kelly E, McClary J, Chou Q, Andrews WH (Nov 1992). "Cloning of the gene coding for a human receptor for ...
For example, this combination led to demonstrate the calcium-dependent heparin binding of Annexin A1 that is involved in ... Glycan array screening works in much the same way as other microarray that is used for instance to study gene expression DNA ... "Characterization of annexin A1 glycan binding reveals binding to highly sulfated glycans with preference for highly sulfated ...
"The gene encoding human annexin V has a TATA-less promoter with a high G+C content". Gene. 149 (2): 253-60. doi:10.1016/0378- ... by competing for phosphatidylserine binding sites with prothrombin and also to inhibit the activity of phospholipase A1. These ... Annexin A5 (or annexin V) is a cellular protein in the annexin group. In flow cytometry, annexin V is commonly used to detect ... Annexin A5 at the US National Library of Medicine Medical Subject Headings (MeSH) Human ANXA5 genome location and ANXA5 gene ...
Nadkarni S, Cooper D, Brancaleone V, Bena S, Perretti M (November 2011). "Activation of the annexin A1 pathway underlies the ... Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes. ... Studies have also shown that the Met allele gene and level of estrogen mediates the efficiency of prefrontal cortex dependent ... Hypothalamic protein levels in the gene COMT are enhanced by increasing estrogen levels which are believed to return mice that ...
... a sequence for the insulin gene Adenosine A3 receptor, a human gene Annexin A3, a human gene ATC code A03 Drugs for functional ... a document given to employees of A-1 and A-2 Visa Holders who are representing a foreign government inside the U.S. A3, the ... an 1851 German steam locomotive model LNER Gresley Classes A1 and A3, a Pacific Locomotive Designed by Sir Nigel Gresley PRR A3 ...
"Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes". ... Once inside the cell, they bind to and activate estrogen receptors (ERs) which in turn modulate the expression of many genes.[5 ... Hypothalamic protein levels in the gene COMT are enhanced by increasing estrogen levels which are believed to return mice that ... 89 such genes were identified). Since estrogen enters all cells, its actions are dependent on the presence of the ER in the ...
This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it. *v ... Annexin *A1. *A2. *A5. *Fibulin *FBLN1. *FBLN2. *FBLN5. *Vitamin D-dependent calcium-binding protein/Calbindin ... Mutations in the cardiac calsequestrin gene have been associated with cardiac arrhythmia and sudden death. CASQ2 is thought ...
... annexin A1 (an inhibitor of formation of pro-inflammatory metabolites of polyunsaturated fatty acids), and the gaseous ... NFE2L2 becomes free to translocate to the nuclease and stimulate the transcription of genes that encode proteins active in ... they have been termed pro-resolving mediators of inflammation Mice made deficient in their 12/15-lipoxygenase gene (Alox15) ... IKK2 component of the cytosolic IKK2-NFκB protein complex thereby inhibiting NFκB from stimulating the transcription of genes ...
... heme-responsive gene protein (HRG) Family 2.A.111 The Na+/H+ Antiporter-E (NhaE) Family 2.A.112 The KX Blood-group Antigen (KXA ... Family 2.B.8 The Bafilomycin A1 (Bafilomycin) Family 2.B.9 The Cell Penetrating Peptide (CPP) Functional Family 2.B.10 The ... or Na+-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily 1.A.31 Annexin family ... family 1.A.12 Intracellular chloride channel family 1.A.13 Epithelial chloride channel family 1.A.14 Testis-enhanced gene ...
... , also known as S100 calcium-binding protein A1 is a protein which in humans is encoded by the S100A1 gene. S100A1 is ... Garbuglia M, Verzini M, Donato R (Sep 1998). "Annexin VI binds S100A1 and S100B and blocks the ability of S100A1 and S100B to ... "Entrez Gene: S100A1 S100 calcium binding protein A1". Morii K, Tanaka R, Takahashi Y, Minoshima S, Fukuyama R, Shimizu N, ... "S100A1 gene transfer: a strategy to strengthen engineered cardiac grafts". The Journal of Gene Medicine. 6 (4): 387-94. doi: ...
IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR037104. Annexin_sf. IPR002388. ANX1. ... IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR037104. Annexin_sf. IPR002388. ANX1. ... sp,P24551,ANXA1_RODSP Annexin A1 OS=Rodentia sp. OX=69158 GN=ANXA1 PE=2 SV=3 ... Annexin 1Add BLAST. 61. ,p>This subsection of the Family and Domains section indicates the positions and types of repeated ...
Unconjugated Whole IgG Rabbit anti-ANXA1/Annexin A1 Antibody, Affinity Purified suitable for WB, IP, IHC applications. Visit ... Gene and Protein Information. Gene ID. 301 Gene Name. annexin A1 Gene Symbol. ANXA1 ... ANXA1/Annexin A1 Antibody, A305-235A. ANXA1/Annexin A1 Antibody, A305-235A. ...
Rabbit polyclonal Annexin A1 antibody validated for WB, IHC, ICC/IF and tested in Human. Immunogen corresponding to recombinant ... Entrez Gene: 301 Human. *Omim: 151690 Human. *SwissProt: P04083 Human. *Unigene: 494173 Human ... Anti-Annexin A1 antibody (ab97485) at 1/1000 dilution + H1299 whole cell lysate at 30 µg. Predicted band size : 39 kDa. ... Recombinant protein fragment containing a sequence corresponding to a region within amino acids 1-198 of Human Annexin A1 ( ...
Rabbit recombinant monoclonal Annexin A1/ANXA1 antibody [EPR19342] conjugated to PE. Validated in Flow Cyt and tested in Mouse ... Entrez Gene: 301 Human. *Entrez Gene: 16952 Mouse. *Entrez Gene: 25380 Rat ... Anti-Annexin A1/ANXA1 antibody [EPR19342] (ab214486) *Anti-Annexin A1/ANXA1 antibody [EPR19342] - BSA and Azide free (ab222398 ... Anti-Annexin A1/ANXA1 antibody [EPR19342] (Allophycocyanin) (ab225511) *Anti-Annexin A1/ANXA1 antibody [EPR19342] (Alexa Fluor ...
Annexin A1, also known as lipocortin I, is a protein that is encoded by the ANXA1 gene in humans. Annexin A1 belongs to the ... Annexin A1 has also been shown to be associated with treatment resistance. ARID1A loss activates annexin A1 expression, which ... annexin A1 is promptly mobilized to the cell surface and secreted. Annexin A1 promotes neutrophil detachment and apoptosis, and ... The gene for annexin A1 (ANXA1) is upregulated in hairy cell leukemia. ANXA1 protein expression is specific to hairy cell ...
Here, we characterize a small recurrent duplication in the annexin A1 (ANXA1) gene, identified by the Autism Genome Project ( ... From the AGP CNV genomic screen in 2,147 ASD individuals, we selected for characterization an ANXA1 gene duplication that was ... Annexin A1, previously known as lipocortin 1, is a 37 kDa protein belonging to the annexin protein superfamily. Annexin A1 was ... Here, we report a small recurrent CNV duplicating a segment of the annexin A1 gene (ANXA1) in ASD subjects, and its detailed ...
Annexin A1, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene ... Search results for 149 available Annexin a1 gene related products. *Overview of 149 available Annexin a1 gene related products ... Search results for 149 available Annexin a1 gene related products. *Overview of 149 available Annexin a1 gene related products ... Search results for 149 available Annexin a1 gene related products. *Overview of 149 available Annexin a1 gene related products ...
Mono-Ubiquitination of Nuclear Annexin A1 and Mutagenesis , IntechOpen, Published on: 2012-08-17. Authors: Fusao Hirata, George ... it is likely that nuclear annexin A1 is involved in DNA replication, especially DNA damage induced gene mutation, since DNA ... Native annexin A1 was detected at pI 6.4. The reaction mixture containing SUMOylated annexin A1 showed a new annexin A1 ... when amounts of ubiquitinated annexin A1 were adjusted with the total amounts of annexin A1 (free and ubiquitinated annexin A1 ...
Downstream gene activation of the receptor ALX by the agonist Annexin A1. PLoS ONE. 5 (9), p. e12771. ... Downstream gene activation of the receptor ALX by the agonist Annexin A1. Renshaw, D., Montero-Melendez, T., Dalli, J., Kamal, ... Downstream gene activation of the receptor ALX by the agonist Annexin A1. ... westminsterresearch.westminster.ac.uk/item/90797/downstream-gene-activation-of-the-receptor-alx-by-the-agonist-annexin-a1 ...
Annexin A1; GSTP1: Glutathione S-transferase P; CD44: CD44 antigen. ... The overall outcome of such analysis is a list of key pathways and genes that includes well-studied genes as well as genes that ... green colors are pathways supported by only proteins and genes, blue pathways are based on gene data only. ... F) Differential expression of metabolic genes (raw p-value ,0.05) found in at least 7 GEO studies. KS p-values calculated from ...
Annexin A1 antibody Mouse Monoclonal from Proteintech validated in Western Blot (WB), Immunohistochemistry (IHC), ... WB protocol for Annexin A1 antibody 66344-1-Ig. Download protocol. IHC protocol for Annexin A1 antibody 66344-1-Ig. Download ... Annexin 1, annexin A1, Annexin I, ANX1, ANXA1, Calpactin 2, Calpactin II, Chromobindin 9, Lipocortin I, LPC1, p35 ... Annexin A1 Antibody. Annexin A1 Monoclonal Antibody for IF, IHC, WB, ELISA. ...
Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast ... Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast ... Genetic polymorphism of miRNA-196a and its target gene annexin-A1 expression based on ethnicity in Pakistani female breast ... ANXA1 gene expression; Breast cancer; Single nucleotide polymorphism; annexin-A1; miR-196a ...
Gene expressions were analysed via RT-qPCR and normalised against GAPDH. Statistical analysis was preformed using GraphPad ... The expression of Annexin A1 (ANXA1); an anti-inflammatory protein, increases in the adipose tissue in response to obesity and ... Exploring the roles of Annexin A1 in adipocytes using an in vitro model of obesity. Sehar Sajid, Bernard Burke, Christopher Mee ... Exploring the roles of Annexin A1 in adipocytes using an ,em,in vitro,/em, model of obesity (. ...
... annexin A1), Authors: Flavia Cristina Rodrigues-Lisoni, Tiago Henrique, Eloiza Helena Tajara. Published in: Atlas Genet ... The ANXA1 gene encodes a 38.71 kDa protein. Similarly to other annexins, annexin A1 is characterized by a C-terminal homologous ... Mouse lipocortin I gene structure and chromosomal assignment: gene duplication and the origins of a gene family.. ... Loss of annexin A1 expression in breast cancer progression.. Cao Y, Li Y, Edelweiss M, Arun B, Rosen D, Resetkova E, Wu Y, Liu ...
2013) Annexin A1, formyl peptide receptor, and NOX1 orchestrate epithelial repair. J Clin Invest 123:443-454. ... Validating the Convergent Gene Losses.. To rule out that any of these gene losses were falsely detected due to artifacts, such ... Given that conserved genes can have inactivating mutations close to the N or C terminus (56), we considered genes with %intact ... Genes with %intact ≤ 60% have one or more mutations in the middle, which indicates that these genes cannot encode a functional ...
Gene Info. ANXA1. Annexin A1. NM_000700. Gene Info. ANXA2. Annexin A2. NM_001136015. NM_001002857. NM_001002858. NM_004039. ... Aldehyde dehydrogenase 1 family, member A1. NM_000689. Gene Info. ALDH1A2. Aldehyde dehydrogenase 1 family, member A2. NM_ ... Gene Info. CDC73. Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae). NM_024529. Gene ... Gene Info. ACSS1. Acyl-CoA synthetase short-chain family member 1. NM_032501. NM_001252675. NM_001252676. NM_001252677. Gene ...
Annexin A1. NM_000700. Gene Info. ANXA10. Annexin A10. NM_007193. Gene Info. ... Annexin A13. NM_001003954. NM_004306. Gene Info. ANXA2. Annexin A2. NM_001136015. NM_001002857. NM_001002858. NM_004039. Gene ... Annexin A9. NM_003568. Gene Info. AP2A2. Adaptor-related protein complex 2, alpha 2 subunit. NM_001242837. NM_012305. Gene Info ... Aldehyde dehydrogenase 1 family, member A1. NM_000689. Gene Info. ALDH1A2. Aldehyde dehydrogenase 1 family, member A2. NM_ ...
Annexin A1 (ANXA1) Recombinant Protein-NP_001075336.1 (MBS1346876) product datasheet at MyBioSource, Recombinant Proteins ... NCBI/Uniprot data below describe general gene information for ANXA1. It may not necessarily be applicable to this product. ... Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately ... Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since ...
Gene Symbol:. Anxa1. Gene Name:. Annexin A1 Aliases:. Not Available. RefSeq:. NM_012904. ... Gene-specific PCR primers for the unbiased preamplification of small quantities of cDNA for subsequent use in downstream gene ... Home , Life Science Research , Products , PCR Amplification , PrimePCR™ PCR Primers, Assays, and Arrays , Gene: Anxa1, Rat , ... Gene-specific synthetic DNA template designed to give a positive real-time PCR result when used with the corresponding probe ...
The genes found using the RaSH technique were analyzed by Gene Ontology (GO) using Ingenuity Systems. The five genes found to ... The E. tirucalli latex treatment down-regulated ITPR1 and up-regulated ANXA1 and CD55 genes, and was validated by real-time ... The RaSH showed change in the expression of some genes, including ANXA1, TCEA1, NGFRAP1, ITPR1 and CD55, which are associated ... The data indicate the involvement of E. tirucalli latex in the altered expression of genes involved in tumorigenic processes, ...
Downstream Gene Activation of the Receptor ALX by the Agonist Annexin A1 PLoS One, Sep 2010, Vol.5(9), p.e12771 [Peer Reviewed ... Up-Regulation of Annexin-A1 and Lipoxin A4 in Individuals with Ulcerative Colitis May Promote Mucosal Homeostasis PLoS One, Jun ... Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet PLoS One, ... Characterizing the anti-inflammatory and tissue protective actions of a novel Annexin A1 peptide PLoS One, Apr 2017, Vol.12(4 ...
It has been shown that N-terminal portion of the Annexin A1 protein (AnxA1) with its anti-inflammatory properties induces ... enhanced gene and protein levels of the vascular growth factor-A (VEGF-A) and fibroblast influx into allograft tissue. It also ... enhanced gene and protein levels of the vascular growth factor-A (VEGF-A) and fibroblast influx into allograft tissue. It also ... It has been shown that N-terminal portion of the Annexin A1 protein (AnxA1) with its anti-inflammatory properties induces ...
Annexin A1 in the brain-undiscovered roles? Trends Pharmacol. Sci. 2008;29(3):135-142.. Gary A. Churchill. Aitman TJ, Boone C, ... "Putting the genes in context allows us to make predictions that are much stronger than just sets of individual genes by ... Annexin A1 in the brain-undiscovered roles? Trends Pharmacol. Sci. 2008;29(3):135-142.. Aron Geurts. Dwinell MR, Lazar J, ... Annexin A1 and the formyl peptide receptor family: neuroendocrine and metabolic aspects. Curr. Opin. Pharmacol. 2008;8(6):765- ...
IPR001464 Annexin. IPR018502 Annexin_repeat. IPR018252 Annexin_repeat_CS. IPR037104 Annexin_sf. IPR009118 AnnexinD_plant. ... IPR001464 Annexin. IPR018502 Annexin_repeat. IPR018252 Annexin_repeat_CS. IPR037104 Annexin_sf. IPR009118 AnnexinD_plant. ... Annexin A1. ,p>This subsection of the ,a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy,/a> ... Annexin, Repeat. Phylogenomic databases. evolutionary genealogy of genes: Non-supervised Orthologous Groups ...
ProteinAntibodyLevels of annexinPathwaysMember of the annexin familyMRNAMiceLipocortinEnsemblInflammatoryPeptideOntologyMutationsGlucocorticoidsMolecularInflammationDifferentially Expressed GenesMouse monoclonalAntibodiesDownstreamCDNADifferential expressionTumorsTissuesTargetsBelongsNeutrophilPlasma membraneExpression of genes involServe as biomarkersReceptorSpeciesTissueTherapeuticProliferation and invasionSignificantlySecretion
- Annexin A1 protein has an apparent relative molecular mass of 40 kDa with phospholipase A2 inhibitory activity. (wikipedia.org)
- Higher expression of annexin A1 during pathological conditions could increase the strength of TCR signalling through the mitogen-activated protein kinase signalling pathway, thereby causing a state of hyperactivation of T cells. (wikipedia.org)
- This gene encodes a membrane-localized protein that binds phospholipids. (genecards.org)
- Overview of multi-omics data mining to reveal metabolic dysregulation by integrating raw p -values from metabolite, protein and gene expression analysis. (nih.gov)
- The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. (nih.gov)
- Previous candidate gene studies further revealed associations between the inactivation (loss) of protein-coding genes and dietary specializations. (pnas.org)
- Schematic representation of annexin protein. (atlasgeneticsoncology.org)
- The comparison of conserved and variable residues between human annexin 1 protein and annexin protein from different vertebrates shows amino acid identities of 100% (Pan troglodytes), 91% (Canis familiars), 87% (Mus musculus), 89% (Rattus norvegicus) and 77% (Gallus gallus) (Rodrigues-Lisoni et al. (atlasgeneticsoncology.org)
- Potential advantages of a full cDNA versus a mini-gene include: maintaining structural-functional protein domains, evading protein misfolding, and avoiding novel epitopes that could be immunogenic. (plos.org)
- Herein we show for the first time in vivo that homologous recombination following AAV5.DYSF gene transfer leads to the production of full length transcript and protein. (plos.org)
- Moreover, gene transfer of full-length dysferlin protein in dysferlin deficient mice resulted in expression levels sufficient to correct functional deficits in the diaphragm and importantly in skeletal muscle membrane repair. (plos.org)
- In addition, ANX A1 protein has been identified as a key regulator in some important signaling pathways, which influences cytoskeletal remodeling in many diseases, such as lung cancer, liver cancer, etc. (biomedcentral.com)
- In this study, we found that the serum from a common bile duct ligation(CBDL) Rat model decreased the expression levels of the ANX A1 mRNA and protein by at least two-fold in human PMVECs. (biomedcentral.com)
- FUTURE DIRECTIONS: Not only a heightened realization is required to unravel various gene/protein networks associated with cancer formation and progression, particularly from the redox standpoint, but there is also a need for developing more sensitive tools for assessing cancer redox metabolism in clinical settings. (nus.edu.sg)
- Efficiently clone and express your target protein by cloning your gene into one of our industry leading bacterial, mammalian or insect cell systems. (merckmillipore.com)
- Along these lines, we found the expression of the gene Lgals1 , which encodes the [beta]-galactoside-binding protein galectin-1 (Barondes et al. (thefreedictionary.com)
- Also known as Annexin A1 (Annexin I) (Annexin-1) (Calpactin II) (Calpactin-2) (Chromobindin-9) (Lipocortin I) (Lipocortin-like 33 kDa protein) (Phospholipase A2 inhibitory protein) (p35). (mybiosource.com)
- Here, we show that androgen exposure regulates genes previously implicated in prostate carcinogenesis comprising pathways for the phosphatase and tensin homolog (PTEN), fibroblast growth factor (FGF)/mitogen-activated protein kinase (MAPK), and Wnt signaling along with cellular programs regulating such 'hallmarks' of cancer as angiogenesis, apoptosis, migration and proliferation. (nih.gov)
- Among the genes with the most significant links to the development and cancer, we highlight coordinate induction of the transcription factor Sox9 and suppression of the proapoptotic phospholipid-binding protein Annexin A1 that link early prostate development to early prostate carcinogenesis. (nih.gov)
- Host: Mouse Isotype: IgG2aκ Immunogen: Human Annexin A4 (NP_001144.1, 1 aa-321 aa) full-length recombinant protein with 6xHis tag. (canvaxbiotech.com)
- Our lab discovered that glucocorticoids can release a protein (called Annexin A1) from some cell types and that this mediates many of the acute effects of these hormone-drugs including their anti-inflammatory actions. (qmul.ac.uk)
- Over the years we have studied this protein in great detail developing transgenic mice lacking the Annexin A1 gene to aid us with our studies. (qmul.ac.uk)
- My current interest focuses on the biology of the Annexin A1 G-protein coupled receptor, ALX/FPR2 and its possible use as a novel therapeutic target. (qmul.ac.uk)
- A functional study of these genes revealed changes in the pathways related to nitric oxide and reactive oxygen species production, Interleukin-12 signalling and production in macrophages and Interleukin-8 signalling with up-regulation of S100 calcium-binding protein A8, Matrix metallopeptidase 9 and CXC chemokine receptor 2 genes. (biomedcentral.com)
- The finding was confirmed at the gene level by quantitative reverse transcription-polymerase chain reaction and at the protein level by immunohistochemical staining of normal, benign, and malignant breast tissues. (nih.gov)
- Reduced expression of the protein ANNEXIN-A1 correlated with higher stemness indices in samples of lung adenocarcinoma. (eurekalert.org)
- Objective-To determine whether a mechanism exists that could operate on application of cromones, antiallertic 'mast cell-stabilizing' drugs that release the anti-inflammatory protein annexin-A1 (Anx-A1) from U937 cells and inhibit polymorphonuclear leukocyte (PMN) trafficking, because PMNs can synthesize and release large amounts of Anx-A1. (westminster.ac.uk)
- Western blotting experiments revealed that cromones stimulate protein kinase C-dependent phosphorylation and release Anx-A1 in human PMNs. (westminster.ac.uk)
- High throughput array studies of the breast cancer cell line BT474 has suggested that there is a correlation between DNA copy numbers and gene expression in highly amplified areas ( 2 ), and studies of individual genes in solid tumors have revealed a good correlation between gene dose and mRNA or protein levels in the case of c-erb-B2, cyclin d1 , ems1 , and N-myc ( 3 - 5 ). (mcponline.org)
- In this investigation we have combined genome-wide technology for detecting genomic gains and losses (CGH) with gene expression profiling techniques (microarrays and proteomics) to determine the effect of gene copy number on transcript and protein levels in pairs of non-invasive and invasive human bladder TCCs. (mcponline.org)
- Histone deacetylase inhibitors (HDACi) are epigenetically active drugs that induce the hyperacetylation of lysine residues within histone and non-histone proteins, thus affecting gene expression and cellular processes such as protein-protein interactions, protein stability, DNA binding and protein sub-cellular localization. (springer.com)
- Description This Annexin V calcium dependent phospholipid binding protein will be downstream of BCL2 pathway and at caspase apoptotic level. (gentaur.com)
- It is usually due to de novo loss of function mutations in the X-linked gene, MeCP2 , which codes for the gene expression and chromatin regulator, methyl-CpG binding protein 2. (springermedizin.de)
- We showed that mRNA and corresponding steady-state protein concentrations correlate well by introducing a gene-specific RNA-to-protein conversion factor that is stable across various cell types and tissues. (diva-portal.org)
- The crystal and molecular structure of human annexin V, an anticoagulant protein that binds to calcium and membranes. (embl.de)
- Among the upregulated proteins identified, mRNA levels of annexin A1, macrophage-capping protein (CapG), S100 calcium-binding protein A4 (S100A4), S100A11, acyl-CoA-binding protein and calcyclin-binding protein also increased. (elsevier.com)
- Quantitative real time polymerase chain reaction (qRT-PCR) and Western analysis were used to compare levels of expression for key calcium channel protein genes and protein product in primate and rodent ON. (biomedcentral.com)
- Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C. (semanticscholar.org)
- The purpose of this study was to investigate the effect of annexin-A1 protein as an endogenous regulator of the organ remote injury induced by intestinal ischemia/reperfusion. (biomedcentral.com)
- Annexin A2 (calpactin I, chromobindin 8, p36, Lipocortin II, PAP-IV, or Protein I) is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of cortocosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. (ecmbio.com)
- This antibody detects a 36 kDa* protein corresponding to the molecular mass of Annexin A2 on SDS-PAGE immunoblots of rat PC12 cells. (ecmbio.com)
- Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66344-1-Ig( Annexin A1 antibody at dilution of 1:200 (under 10x lens). (ptglab.com)
- Immunohistochemical analysis of paraffin-embedded human stomach tissue slide using 66344-1-Ig( Annexin A1 antibody at dilution of 1:200 (under 40x lens). (ptglab.com)
- Immunohistochemical analysis of Annexin I using anti-Annexin I Polyclonal Antibody (Product # PA5-32264) in Placenta Tissue. (antibodypedia.com)
- The antibody has been shown to label Annexin A2 in immunocytochemical analysis of PC12 cells and immunohistochemical analysis of mouse diaphragm. (ecmbio.com)
- The blot was probed with mouse monoclonal anti-Annexin A2 antibody at 1:250 (lane 1) or 1:1000 (lane 2). (ecmbio.com)
- In resting conditions, human and mouse immune cells such as neutrophils, monocytes, and macrophages contain high levels of annexin A1 in their cytoplasm. (wikipedia.org)
- Indeed, certain types of cancers such as hepatoma and pancreas cancers have higher levels of annexin A1 ( Lim & Pervaiz, 2007 ). (intechopen.com)
- In keeping with this interpretation, some types of cancers such as esophageal carcinoma and prostate cancer have decreased levels of annexin A1 ( Lim & Pervaiz, 2007 ). (intechopen.com)
- The overall outcome of such analysis is a list of key pathways and genes that includes well-studied genes as well as genes that have rarely been reported before in the context of breast cancer. (nih.gov)
- Microarray analysis of these cells also revealed a unique gene fingerprint with key signaling pathways involved in autoimmunity being modulated. (frontiersin.org)
- The activated GR can then regulate gene expression via one of two pathways: Transactivation The first (direct) pathway is called transactivation whereby the activated GR dimerizes, is translocated into the nucleus and binds to specific sequences of DNA called glucocorticoid response elements (GREs). (wikipedia.org)
- Most importantly, early androgen-regulated genes and functional themes associated with prostate development were highly enriched in contrasts between increasingly lethal forms of prostate cancer, confirming a 'reactivation' of embryonic pathways for proliferation and invasion in prostate cancer progression. (nih.gov)
- These results credential early prostate development as a reliable and valid model system for the investigation of genes and pathways that drive prostate cancer. (nih.gov)
- These findings suggest that vectors targeting the ER (Ad-ER-mda7) may be more effective in cancer gene therapy possibly through more effective induction or ER stress pathways. (labome.org)
- An important gene associated with Splenic Diffuse Red Pulp Small B-Cell Lymphoma is BCOR (BCL6 Corepressor), and among its related pathways/superpathways are GPCR Pathway and PI3K-Akt signaling pathway . (malacards.org)
- Furthermore, lymph nodes taken from AnxA1null mice displayed lower SGPP2 gene activity. (westminster.ac.uk)
- We therefore compared gene expression profiles in myocardial and skeletal muscle tissues of dysferlin-deficient SJL/J mice. (jimmunol.org)
- The present study provides a first report of microarray-based technology for describing changes in the splenic gene expression profile for mice immunised with a highly effective, protection-inducing, multi-epitope, subunit-based, chemically-synthesised vaccine candidate against F. hepatica . (biomedcentral.com)
- Analysis of MOG 35-55 -induced EAE development in Annexin A1 null mice showed decreased signs of the disease compared to wild type mice. (biomedcentral.com)
- Together these findings suggest that Annexin A1 null mice have an impaired capacity to develop EAE. (biomedcentral.com)
- 0.05) inhibited cell adhesion and emigration, as well as myeloperoxidase release, in wild-type but not Anx-A1-/- mice. (westminster.ac.uk)
- The main mechanism of glucocorticoids' anti-inflammatory effects is to increase the synthesis and function of annexin A1. (wikipedia.org)
- Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins, and leukotrienes, annexin A1 may have potential anti-inflammatory activity. (wikipedia.org)
- Upon induction by modified NSAIDS and other potent anti-inflammatory drugs, annexin A1 inhibits the NF-κB signal transduction pathway, which is exploited by cancerous cells to proliferate and avoid apoptosis. (wikipedia.org)
- Finally, robustness of the inflammatory gene network is also inferred by analyzing the hubs and "weak ties" structures of the gene network. (biomedcentral.com)
- In this study, Data mining and dynamic network analyses were integrated to examine the gene regulatory network in the inflammatory response system. (biomedcentral.com)
- This study examines the potential clinical utility of an inflammatory gene expression signature as a prognostic biomarker for colon cancer in addition to previously examined miR-21 expression. (aacrjournals.org)
- was used to measure the expression of 23 inflammatory genes in colon adenocarcinomas and adjacent noncancerous tissues from 196 patients. (aacrjournals.org)
- Expression data for miR-21 were available for these patients and were compared and combined with inflammatory gene expression. (aacrjournals.org)
- Expression of miR-21 was associated with IL-6, IL-8, IL-10, IL-12a , and NOS2a , providing evidence that the function of this microRNA and these inflammatory genes are linked. (aacrjournals.org)
- We report that the expression pattern of inflammatory-related genes in tumors and paired noncancerous tissues was an independent prognostic marker for colon adenocarcinoma patients. (aacrjournals.org)
- The combination of the inflammatory gene signature with available miR-21 expression data improved predictions with prognosis over either alone. (aacrjournals.org)
- Because inflammation contributes to colon carcinogenesis, expression of inflammatory genes may serve as biomarkers for colon cancer. (aacrjournals.org)
- Polymorphisms in inflammatory genes have been associated with colon cancer incidence and prognosis ( 16 - 18 ). (aacrjournals.org)
- Expression of inflammatory genes has also been associated with TNM staging and prognosis in colon cancer ( 19 , 20 ). (aacrjournals.org)
- Moreover, some pro-inflammatory properties have recently emerged, based on the analysis of glucocorticoid-regulated genes. (springer.com)
- Conclusion: In a rabbit model of saccular aneurysm, high AR was associated with differential expression of inflammatory/immunomodulatory genes, structural genes, genes related to proteolytic enzymes and extracellular matrix-related genes. (elsevier.com)
- Anti-inflammatory drugs, eicosanoids and the annexin A1/FPR2 anti-inflammatory system. (semanticscholar.org)
- Our data suggest that the annexin-A1 peptidomimetic Ac2-26 treatment has a regulatory and protective effect in the intestinal ischemia/reperfusion by attenuation of the leukocyte migration to the lung and induction of the anti-inflammatory cytokine IL-10 release into the plasma. (biomedcentral.com)
- The anti-inflammatory action of annexin-A1 and its peptidomimetic described here may serve as a basis for future therapeutic approach in mitigating inflammatory processes due to intestinal ischemia/reperfusion. (biomedcentral.com)
- The annexin-1 knockout mouse: what it tells us about the inflammatory response. (deathbase.org)
- These data highlight the role of annexin-1 and peptide derivatives in promoting the resolution of inflammation and expand on the therapeutic anti-inflammatory potential of annexin-1. (deathbase.org)
- Array expression data revealed that EA induced a pro-inflammatory and adipogenic transcriptional profile compared with OA, although with modest effects on selected ( n = 9) gene promoter methylation. (biomedcentral.com)
- Annexin-1 signals mitogen-stimulated breast tumor cell proliferation by activation of the formyl peptide receptors (FPRs) 1 and 2. (semanticscholar.org)
- A synthetic peptide corresponding to a sequence near the C-terminal of human Annexin A1, different from the related rat and mouse sequence by two amino acids. (abcam.cn)
- Treatment with annexin-A1 peptidomimetic Ac2-26, reduced the number of neutrophils in the lung tissue and increased its number in the blood vessels, which suggests a regulatory effect of the peptide Ac2-26 in the neutrophil migration. (biomedcentral.com)
- Annexin-1 and peptide derivatives are released by apoptotic cells and stimulate phagocytosis of apoptotic neutrophils by macrophages. (deathbase.org)
- Using nanoelectrospray liquid chromatography mass spectrometry and immunodepletion and immunoneutralization studies, we have ascertained that annexin-1 and peptide derivatives are putative prophagocytic factors released by apoptotic cells that promote phagocytosis of apoptotic PMN by M[phi] and differentiated THP-1 cells. (deathbase.org)
- Activating KIT mutations have been identified in 80% to 90% of GISTs, and mutation of the platelet-derived growth factor receptor alpha gene ( PDGFRA ) is observed in approximately 5% of GISTs ( 1-3 ). (aacrjournals.org)
- Although dysferlin is expressed in human skeletal and cardiac muscles ( 1 ), mutations in the encoding gene ( DYSF ) lead only to skeletal muscle phenotypes without myocardial involvement, namely limb girdle muscular dystrophy 2B (LGMD2B) 4 and Miyoshi myopathy ( 4 ). (jimmunol.org)
- First identified as a consequence of chromosomal translocation (t 14:18) in human lymphoma, subsequent studies have revealed mutations and/or gene copy number alterations as well as posttranslational modifications of Bcl-2 in a variety of human cancers. (nus.edu.sg)
- In the case of head and neck squamous cell carcinoma, for example, high stemness indices correlated with mutations in the gene NSD1. (eurekalert.org)
- Accordingly, mutations in the calpain 3 gene cause limb Promotion of Fundamental Medical Research (YH) girdle muscular dystrophy type 2A . (deepdyve.com)
- A tumor suppressor gene DIRAS1 was upregulated after SB treatment, displaying its anti-cancer potential at molecular level. (springer.com)
- The Ingenuity Pathway Analysis tool was then used for analysing differentially expressed gene identifiers for annotating bio-functions and constructing and visualising molecular interaction networks. (biomedcentral.com)
- To analyze the gene expression patterns of the antler growth center in a tissue-differential manner and explore the molecular mechanism responsible for rapid antler growth, we used an RNA-Seq method to analyze gene expression patterns in different tissues of the Sika deer antler growth center during the rapid growth stage. (springer.com)
- He has published effects of stress and drugs of addiction on gene expression in the brain, most recently refining the Drosophila model to investigate molecular mechanisms of alcohol addiction. (uel.ac.uk)
- Our understanding of pro-resolution factors in determining the outcome of inflammation has recently gained ground, yet not many studies have investigated whether specific genes or patterns of genes, are modified by these mediators. (westminster.ac.uk)
- Results: AC2-26 treatment differentially regulated the expression of genes involved in the insulin signalling pathway, adipocytokine signalling pathway, PPAR signalling pathway, metabolism and inflammation. (endocrine-abstracts.org)
- Annexin A1 in inflammation and breast cancer: a new axis in the tumor microenvironment. (semanticscholar.org)
- The gene expression and cytokine profiles of lSSc-PAH patients suggest the presence of activated monocytes, and show markers of vascular injury and inflammation. (pubmedcentralcanada.ca)
- When primary pathogenetic events remains unclear due to its immense complexity, construction and analysis of the gene regulatory network of inflammation at times becomes the best way to understand the detrimental effects of disease. (biomedcentral.com)
- It is hence appealing to find an algorithm which can generate a gene regulatory network of systemic inflammation from high-throughput genomic studies of human diseases. (biomedcentral.com)
- Compared with previous methodologies reported in the literatures, the proposed gene network perturbation method has shown a great improvement in analyzing the systemic inflammation. (biomedcentral.com)
- Many genes associated with normal axonal function, mRNAs associated with axonal transport, inflammation and neuroprotection are observed. (biomedcentral.com)
- 47 genes differentially expressed following the BRD-K29395450_PIK-93_MCF7_24_h_0.12_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. (mssm.edu)
- 161 genes differentially expressed following the BRD-K37043259_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset. (mssm.edu)
- We found a significant overlap in differentially expressed genes (DEGs) with genes involved in regulating the extracellular matrix, and those that are activated or inhibited when macrophages and microglia are stimulated towards the M1 and M2 activation states. (springermedizin.de)
- As with other forms of muscular dystrophy, adeno-associated virus (AAV) gene transfer is a particularly auspicious treatment strategy, however the size of the DYSF cDNA (6.5 kb) negates packaging into traditional AAV serotypes known to express well in muscle (i.e. rAAV1, 2, 6, 8, 9). (plos.org)
- We examined the gene expression profile of human optic nerve (ON) and, through the NEIBANK online resource, to provide a resource of sequenced verified cDNA clones. (biomedcentral.com)
- We conclude that the new cDNA library is a faithful representation of human ON and EST data provide an initial overview of gene expression patterns in this tissue. (biomedcentral.com)
- While many cDNA libraries are normalized (a subtraction hybridization approach to reduce the representation of abundant clones) or amplified (an expansion in which different clones proliferate at different rates), most NEIBank libraries are unnormalized and unamplified so that random sequencing for EST analysis reflects more closely the natural abundance of common gene transcripts in each tissue. (biomedcentral.com)
- Loss of function or expression of this gene has been detected in multiple tumors. (genecards.org)
- Prioritization of metabolic genes as novel therapeutic targets in estrogen-receptor negative breast tumors using multi-omics data and text mining. (nih.gov)
- We have analyzed metabolomics, proteomics and transcriptomics data for a cohort of 276 breast tumors (MetaCancer study) and nine public transcriptomics datasets using univariate statistics, meta-analysis, Reactome pathway analysis, biochemical network mapping and text mining of metabolic genes. (nih.gov)
- Here we have attempted to address this question in pairs of non-invasive and invasive human bladder tumors using a combination of technology that included comparative genomic hybridization, high density oligonucleotide array-based monitoring of transcript levels (5600 genes), and high resolution two-dimensional gel electrophoresis. (mcponline.org)
- By querying public gene expression databases from other tissues, we found that rather than generally characterizing androgen exposure or epithelial budding, the early prostate development program more closely resembles the program for human prostate cancer. (nih.gov)
- We demonstrated considerable diversity in the expression levels of functional genes among different tissues within the antler growth center. (springer.com)
- Under-reported genes were revealed by text mining which may serve as novel candidates for drug targets in cancer therapies. (nih.gov)
- 66344-1-Ig targets Annexin A1 in WB, IHC, IF, ELISA applications and shows reactivity with human, mouse samples. (ptglab.com)
- These findings reveal concurrent overexpression of HOX genes with noncoding RNAs in human cancer in this setting, revealing miR-196a and HOTAIR as potentially useful biomarkers and therapeutic targets in malignant GISTs. (aacrjournals.org)
- These include modulation of gene expression through microRNAs, expression of specific transcription factors, and regulation of their predicted targets. (nih.gov)
- MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. (labome.org)
- Following cell activation (for example, by neutrophil adhesion to endothelial-cell monolayers), annexin A1 is promptly mobilized to the cell surface and secreted. (wikipedia.org)
- Annexin A1 promotes neutrophil detachment and apoptosis, and phagocytosis of apoptotic neutrophils by macrophages. (wikipedia.org)
- 2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. (qmul.ac.uk)
- The activation of T cells results in the release of annexin A1 and the expression of its receptor. (wikipedia.org)
- Exposure of MCF-7 breast cancer cells to high physiological levels (up to 100 nM) of estrogen lead to an up-regulation of annexin A1 expression partially through the activation of CREB, and dependent on activation of the estrogen receptor alpha. (wikipedia.org)
- GO annotations related to this gene include calcium ion binding and receptor binding . (genecards.org)
- 15-Lipoxygenase-2 gene regulation by its product 15-(S)-hydroxyeicosatetraenoic acid through a negative feedback mechanism that involves peroxisome proliferator-activated receptor gamma. (labome.org)
- In this study, we conducted a meta-analysis of gene expression profiles of kidney IRI in human, pig, rat, and mouse models, using a new scoring method to correct for the bias of overrepresented species. (biomedcentral.com)
- The eGWAS results were corrected for a rodent species bias using a new weighted scoring algorithm, which favors genes with unidirectional change in expression in all tested species. (biomedcentral.com)
- The cross-species expression pattern of these genes allowed us to generate three workable hypotheses of kidney IRI, one of which was confirmed by an additional study. (biomedcentral.com)
- Moreover, our new meta-analysis correction method improved gene candidate selection by identifying genes that are model and species independent, as a result, function of these genes can be directly extrapolated to the disease state in human and facilitate translation of potential diagnostic or therapeutic properties of these candidates to the bedside. (biomedcentral.com)
- Therefore, we hypothesized that correction of meta-analysis of IRI-implicated genes for a species bias will not only improve new gene candidate selection, but will identify genes that are model and species independent. (biomedcentral.com)
- Most eukaryotic species have 1-20 annexin (ANX) genes. (embl.de)
- Decreased expression of annexin A1 is correlated with breast cancer development and progression as determined by a tissue microarray analysis. (nih.gov)
- In order to better understand the pathogenesis of KS, we have analysed tissue from two AIDS-KS lesions, and from normal skin by serial analysis of gene expression (SAGE). (biomedcentral.com)
- We provide proof of principle that AAV5 mediated delivery of dysferlin is a highly promising strategy for treatment of dysferlinopathies and has far-reaching implications for the therapeutic delivery of other large genes. (plos.org)
- Therefore, the new diagnostic or therapeutic properties discovered for these genes will be easier translated to a clinical use. (biomedcentral.com)
- Therefore, this gene signature may be useful for identifying high-risk, early-stage patients to assist in decisions regarding appropriate therapeutic intervention. (aacrjournals.org)
- Finally, analysis of the T cell recall response in vitro following stimulation with MOG 35-55 showed a decrease proliferation of Annexin A1 null T cells, with a significantly reduced Th1/Th17 phenotype, compared to wild type cells. (biomedcentral.com)
- The expressions of the annexin A1, CapG and S100A4 genes were significantly induced by hypoxia in five adherent cell lines tested besides U937 cells, while their expressions were blocked by the short hairpin RNA specifically against HIF-1α. (elsevier.com)
- The expression profile of AIDS-KS showed 64 genes to be significantly upregulated, and 28 genes downregulated, compared with normal skin. (biomedcentral.com)