Gastrointestinal Stromal Tumors: All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).Proto-Oncogene Proteins c-kit: A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.Gastrointestinal Neoplasms: Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.Benzamides: BENZOIC ACID amides.PiperazinesPyrimidines: A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.Receptor, Platelet-Derived Growth Factor alpha: A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.Stromal Cells: Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.Antineoplastic Agents: Substances that inhibit or prevent the proliferation of NEOPLASMS.Mesenchymoma: A mixed mesenchymal tumor composed of two or more mesodermal cellular elements not commonly associated, not counting fibrous tissue as one of the elements. Mesenchymomas are widely distributed in the body and about 75% are malignant. (Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)Neoplasms, Connective Tissue: Neoplasms composed of connective tissue, including elastic, mucous, reticular, osseous, and cartilaginous tissue. The concept does not refer to neoplasms located in connective tissue.Epithelioid Cells: Characteristic cells of granulomatous hypersensitivity. They appear as large, flattened cells with increased endoplasmic reticulum. They are believed to be activated macrophages that have differentiated as a result of prolonged antigenic stimulation. Further differentiation or fusion of epithelioid cells is thought to produce multinucleated giant cells (GIANT CELLS).Mitotic Index: An expression of the number of mitoses found in a stated number of cells.Pyrroles: Azoles of one NITROGEN and two double bonds that have aromatic chemical properties.Duodenal Neoplasms: Tumors or cancer of the DUODENUM.Leiomyosarcoma: A sarcoma containing large spindle cells of smooth muscle. Although it rarely occurs in soft tissue, it is common in the viscera. It is the most common soft tissue sarcoma of the gastrointestinal tract and uterus. The median age of patients is 60 years. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1865)Immunohistochemistry: Histochemical localization of immunoreactive substances using labeled antibodies as reagents.Ileal Neoplasms: Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).Jejunal Neoplasms: Tumors or cancer in the JEJUNUM region of the small intestine (INTESTINE, SMALL).Neoplasms, Multiple Primary: Two or more abnormal growths of tissue occurring simultaneously and presumed to be of separate origin. The neoplasms may be histologically the same or different, and may be found in the same or different sites.Mutation: Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.Intestinal Neoplasms: Tumors or cancer of the INTESTINES.Tumor Markers, Biological: Molecular products metabolized and secreted by neoplastic tissue and characterized biochemically in cells or body fluids. They are indicators of tumor stage and grade as well as useful for monitoring responses to treatment and predicting recurrence. Many chemical groups are represented including hormones, antigens, amino and nucleic acids, enzymes, polyamines, and specific cell membrane proteins and lipids.Indoles: Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.Sex Cord-Gonadal Stromal Tumors: Neoplasms derived from the primitive sex cord or gonadal stromal cells of the embryonic GONADS. They are classified by their presumed histogenesis and differentiation. From the sex cord, there are SERTOLI CELL TUMOR and GRANULOSA CELL TUMOR; from the gonadal stroma, LEYDIG CELL TUMOR and THECOMA. These tumors may be identified in either the OVARY or the TESTIS.Protein Kinase Inhibitors: Agents that inhibit PROTEIN KINASES.Stomach Neoplasms: Tumors or cancer of the STOMACH.Tomography, X-Ray Computed: Tomography using x-ray transmission and a computer algorithm to reconstruct the image.Digestive System Surgical Procedures: Surgery performed on the digestive system or its parts.DNA Mutational Analysis: Biochemical identification of mutational changes in a nucleotide sequence.Neurofibromatosis 1: An autosomal dominant inherited disorder (with a high frequency of spontaneous mutations) that features developmental changes in the nervous system, muscles, bones, and skin, most notably in tissue derived from the embryonic NEURAL CREST. Multiple hyperpigmented skin lesions and subcutaneous tumors are the hallmark of this disease. Peripheral and central nervous system neoplasms occur frequently, especially OPTIC NERVE GLIOMA and NEUROFIBROSARCOMA. NF1 is caused by mutations which inactivate the NF1 gene (GENES, NEUROFIBROMATOSIS 1) on chromosome 17q. The incidence of learning disabilities is also elevated in this condition. (From Adams et al., Principles of Neurology, 6th ed, pp1014-18) There is overlap of clinical features with NOONAN SYNDROME in a syndrome called neurofibromatosis-Noonan syndrome. Both the PTPN11 and NF1 gene products are involved in the SIGNAL TRANSDUCTION pathway of Ras (RAS PROTEINS).Sarcoma: A connective tissue neoplasm formed by proliferation of mesodermal cells; it is usually highly malignant.Prognosis: A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.Carney Complex: Autosomal dominant syndrome characterized by cardiac and cutaneous MYXOMAS; LENTIGINOSIS (spotty pigmentation of the skin), and endocrinopathy and its associated endocrine tumors. The cardiac myxomas may lead to SUDDEN CARDIAC DEATH and other complications in Carney complex patients. The gene coding for the PRKAR1A protein is one of the causative genetic loci (type 1). A second locus is at chromosome 2p16 (type 2).Gastrectomy: Excision of the whole (total gastrectomy) or part (subtotal gastrectomy, partial gastrectomy, gastric resection) of the stomach. (Dorland, 28th ed)Leiomyoma: A benign tumor derived from smooth muscle tissue, also known as a fibroid tumor. They rarely occur outside of the UTERUS and the GASTROINTESTINAL TRACT but can occur in the SKIN and SUBCUTANEOUS TISSUE, probably arising from the smooth muscle of small blood vessels in these tissues.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Antigens, CD34: Glycoproteins found on immature hematopoietic cells and endothelial cells. They are the only molecules to date whose expression within the blood system is restricted to a small number of progenitor cells in the bone marrow.Drug Resistance, Neoplasm: Resistance or diminished response of a neoplasm to an antineoplastic agent in humans, animals, or cell or tissue cultures.Interstitial Cells of Cajal: c-Kit positive cells related to SMOOTH MUSCLE CELLS that are intercalated between the autonomic nerves and the effector smooth muscle cells of the GASTROINTESTINAL TRACT. Different phenotypic classes play roles as pacemakers, mediators of neural inputs, and mechanosensors.Endosonography: Ultrasonography of internal organs using an ultrasound transducer sometimes mounted on a fiberoptic endoscope. In endosonography the transducer converts electronic signals into acoustic pulses or continuous waves and acts also as a receiver to detect reflected pulses from within the organ. An audiovisual-electronic interface converts the detected or processed echo signals, which pass through the electronics of the instrument, into a form that the technologist can evaluate. The procedure should not be confused with ENDOSCOPY which employs a special instrument called an endoscope. The "endo-" of endosonography refers to the examination of tissue within hollow organs, with reference to the usual ultrasonography procedure which is performed externally or transcutaneously.Exons: The parts of a transcript of a split GENE remaining after the INTRONS are removed. They are spliced together to become a MESSENGER RNA or other functional RNA.Disease-Free Survival: Period after successful treatment in which there is no appearance of the symptoms or effects of the disease.Laparotomy: Incision into the side of the abdomen between the ribs and pelvis.Neurilemmoma: A neoplasm that arises from SCHWANN CELLS of the cranial, peripheral, and autonomic nerves. Clinically, these tumors may present as a cranial neuropathy, abdominal or soft tissue mass, intracranial lesion, or with spinal cord compression. Histologically, these tumors are encapsulated, highly vascular, and composed of a homogenous pattern of biphasic fusiform-shaped cells that may have a palisaded appearance. (From DeVita Jr et al., Cancer: Principles and Practice of Oncology, 5th ed, pp964-5)Tumor Burden: The total amount (cell number, weight, size or volume) of tumor cells or tissue in the body.Somatostatinoma: A SOMATOSTATIN-secreting tumor derived from the pancreatic delta cells (SOMATOSTATIN-SECRETING CELLS). It is also found in the INTESTINE. Somatostatinomas are associated with DIABETES MELLITUS; CHOLELITHIASIS; STEATORRHEA; and HYPOCHLORHYDRIA. The majority of somatostatinomas have the potential for METASTASIS.Cell Line, Tumor: A cell line derived from cultured tumor cells.Protein-Tyrosine Kinases: Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.S100 Proteins: A family of highly acidic calcium-binding proteins found in large concentration in the brain and believed to be glial in origin. They are also found in other organs in the body. They have in common the EF-hand motif (EF HAND MOTIFS) found on a number of calcium binding proteins. The name of this family derives from the property of being soluble in a 100% saturated ammonium sulfate solution.Leiomyoma, Epithelioid: A relatively rare smooth muscle tumor found most frequently in the wall of the gastrointestinal tract, especially in the stomach. It is similar to other smooth muscle tumors but may become very large and hemorrhage and exhibit small cystic areas. Simple excision is almost always curative. (From Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1354)Retrospective Studies: Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.Gastroscopy: Endoscopic examination, therapy or surgery of the interior of the stomach.Positron-Emission Tomography: An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.Peritoneal Neoplasms: Tumors or cancer of the PERITONEUM.Disease Progression: The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.Endoscopy, Gastrointestinal: Endoscopic examination, therapy or surgery of the gastrointestinal tract.Electron Transport Complex II: A flavoprotein oxidase complex that contains iron-sulfur centers. It catalyzes the oxidation of SUCCINATE to fumarate and couples the reaction to the reduction of UBIQUINONE to ubiquinol.Double-Balloon Enteroscopy: Endoscopy of the small intestines accomplished while advancing the endoscope into the intestines from the stomach by alternating the inflation of two balloons, one on an innertube of the endoscope and the other on an overtube.Omentum: A double-layered fold of peritoneum that attaches the STOMACH to other organs in the ABDOMINAL CAVITY.Pelvic Neoplasms: Tumors or cancer of the pelvic region.Neurofibrosarcoma: A malignant tumor that arises from small cutaneous nerves, is locally aggressive, and has a potential for metastasis. Characteristic histopathologic features include proliferating atypical spindle cells with slender wavy and pointed nuclei, hypocellular areas, and areas featuring organized whorls of fibroblastic proliferation. The most common primary sites are the extremities, retroperitoneum, and trunk. These tumors tend to present in childhood, often in association with NEUROFIBROMATOSIS 1. (From DeVita et al., Cancer: Principles & Practice of Oncology, 5th ed, p1662; Mayo Clin Proc 1990 Feb;65(2):164-72)Incidental Findings: Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.Ki-67 Antigen: A CELL CYCLE and tumor growth marker which can be readily detected using IMMUNOCYTOCHEMISTRY methods. Ki-67 is a nuclear antigen present only in the nuclei of cycling cells.Neoplasm Metastasis: The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.Soft Tissue Neoplasms: Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.Intestine, Small: The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.Gastrointestinal Hemorrhage: Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.Succinate Dehydrogenase: A flavoprotein containing oxidoreductase that catalyzes the dehydrogenation of SUCCINATE to fumarate. In most eukaryotic organisms this enzyme is a component of mitochondrial electron transport complex II.Hemoperitoneum: Accumulations of blood in the PERITONEAL CAVITY due to internal HEMORRHAGE.Neoadjuvant Therapy: Preliminary cancer therapy (chemotherapy, radiation therapy, hormone/endocrine therapy, immunotherapy, hyperthermia, etc.) that precedes a necessary second modality of treatment.Cell Proliferation: All of the processes involved in increasing CELL NUMBER including CELL DIVISION.DNA, Neoplasm: DNA present in neoplastic tissue.Biopsy, Needle: Removal and examination of tissue obtained through a transdermal needle inserted into the specific region, organ, or tissue being analyzed.Liver Neoplasms: Tumors or cancer of the LIVER.Gene Expression Regulation, Neoplastic: Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.Lethargy: A general state of sluggishness, listless, or uninterested, with being tired, and having difficulty concentrating and doing simple tasks. It may be related to DEPRESSION or DRUG ADDICTION.Meckel Diverticulum: A congenital abnormality characterized by the outpouching or sac formation in the ILEUM. It is a remnant of the embryonic YOLK SAC in which the VITELLINE DUCT failed to close.Neoplasm Proteins: Proteins whose abnormal expression (gain or loss) are associated with the development, growth, or progression of NEOPLASMS. Some neoplasm proteins are tumor antigens (ANTIGENS, NEOPLASM), i.e. they induce an immune reaction to their tumor. Many neoplasm proteins have been characterized and are used as tumor markers (BIOMARKERS, TUMOR) when they are detectable in cells and body fluids as monitors for the presence or growth of tumors. Abnormal expression of ONCOGENE PROTEINS is involved in neoplastic transformation, whereas the loss of expression of TUMOR SUPPRESSOR PROTEINS is involved with the loss of growth control and progression of the neoplasm.Endometrial Stromal Tumors: Neoplasms of the endometrial stroma that sometimes involve the MYOMETRIUM. These tumors contain cells that may closely or remotely resemble the normal stromal cells. Endometrial stromal neoplasms are divided into three categories: (1) benign stromal nodules; (2) low-grade stromal sarcoma, or endolymphatic stromal myosis; and (3) malignant endometrial stromal sarcoma (SARCOMA, ENDOMETRIAL STROMAL).Survival Rate: The proportion of survivors in a group, e.g., of patients, studied and followed over a period, or the proportion of persons in a specified group alive at the beginning of a time interval who survive to the end of the interval. It is often studied using life table methods.Neoplasm Recurrence, Local: The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.Neoplasm Staging: Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.Kaplan-Meier Estimate: A nonparametric method of compiling LIFE TABLES or survival tables. It combines calculated probabilities of survival and estimates to allow for observations occurring beyond a measurement threshold, which are assumed to occur randomly. Time intervals are defined as ending each time an event occurs and are therefore unequal. (From Last, A Dictionary of Epidemiology, 1995)Follow-Up Studies: Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.Cecal Neoplasms: Tumors or cancer of the CECUM.
Gastrointestinal stromal tumor (GIST). *Lymphoma. *Sarcoma. *Leiomyoma. *Metastatic tumors, especially SCLC or melanoma ... The small intestine or small bowel is an organ in the gastrointestinal tract where most of the end absorption of nutrients and ... See also: Gastrointestinal disease. The small intestine is a complex organ, and as such, there are a very large number of ... "The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling ...
PIK3CA Gastrointestinal stromal tumor, somatic; 606764; KIT Gastrointestinal stromal tumor, somatic; 606764; PDGFRA Gaucher ... KRT4 Wilms tumor 2; 194071; H19 Wilms tumor; 194070; BRCA2 Wilms tumor, somatic; 194070; GPC3 Wilms tumor, type 1; 194070; WT1 ... CTSC Paraganglioma and gastric stromal sarcoma; 606864; SDHB Paraganglioma and gastric stromal sarcoma; 606864; SDHC ... CPN1 Carcinoid tumors, intestinal; 114900; SDHD Cardiac arrhythmia, ankyrin-B-related; 600919; ANK2 Cardiac conduction defect, ...
"Phase II Study of Crenolanib (CP-868,596), for the Treatment of Patients With Advanced Gastrointestinal Stromal Tumors With the ... of Gastrointestinal stromal tumor. Fusion of PDGFRA has been found to be responsible for hematological malignances like ... gastrointestinal stromal tumor (GIST), and glioma. Crenolanib is an orally bioavailable benzamidazole that selectively and ... for the Treatment of Patients With Advanced Gastrointestinal Stromal Tumors With the D842-related Mutations and Deletions in ...
Quek R, George S (February 2009). "Gastrointestinal stromal tumor: a clinical overview". Hematol. Oncol. Clin. North Am. 23 (1 ... 2006). "Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a ... Blay JY, Reichardt P (June 2009). "Advanced gastrointestinal stromal tumor in Europe: a review of updated treatment ... and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib was the first cancer drug ...
gastrointestinal stromal tumors". Cancer Genet. Cytogenet. 135 (1): 1-22. doi:10.1016/S0165-4608(02)00546-0. PMID 12072198. ... Lasota J, Miettinen M (2007). "KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)". Semin Diagn Pathol. 23 (2 ... Activating mutations in this gene are associated with gastrointestinal stromal tumors, testicular seminoma, mast cell disease, ... and gastrointestinal stromal tumors (GISTs). The efficacy of imatinib (trade name Gleevec), a CD117 inhibitor, is determined by ...
Gastrointestinal carcinoid tumor. *Gastrointestinal stromal tumor (GIST). *Hepatocellular cancer. *Pancreatic cancer, islet ... Not all tumors or lumps are cancerous; benign tumors are not classified as being cancer because they do not spread to other ... Benign tumors (which are not cancers) are usually named using -oma as a suffix with the organ name as the root. For example, a ... Germ cell tumor: Cancers derived from pluripotent cells, most often presenting in the testicle or the ovary (seminoma and ...
McWhinney SR, Pasini B, Stratakis CA (2007). "Familial gastrointestinal stromal tumors and germ-line mutations". N. Engl. J. ... Rapid and uncontrolled cell division, along with the formation of new blood vessels, can lead to the development of tumors in ...
Liu FY, Qi JP, Xu FL, Wu AP (2006). "Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor". ...
Gastrointestinal stromal tumors or (GISTs). GIST tumors are sarcomas derived from the GI tract's connective tissue whereas most ... A single mutation, D842V, in this exon accounts for >70% of GIST tumors. The next most common GIST tumor mutation occurs in ... GIST tumors occur throughout the GI track but most (66%) occur in the stomach and when developing there have a lower malignant ... The most common PDGFRA mutations found in GIST tumors occur in exon 18 and are thought to stabilize PDGFRA's tyrosine kinase in ...
CD117 (KIT): for gastrointestinal stromal tumors (GIST) and mast cell tumors. *CD10 (CALLA): for renal cell carcinoma and acute ... Most gastrointestinal stromal tumors express KIT, which can be detected by immunohistochemistry.[14] ... The Gastrointestinal Stromal Tumor Model". Ann. Surg. 244 (2): 176-84. doi:10.1097/01.sla.0000218080.94145.cf. PMC 1602162. ... Many tumors are hormone dependent. The presence of hormone receptors can be used to determine if a tumor is potentially ...
"Hypothyroidism after sunitinib treatment for patients with gastrointestinal stromal tumors". Annals of Internal Medicine. 145 ( ...
... for gastrointestinal stromal tumors (GIST) and mast cell tumors CD10 (CALLA): for renal cell carcinoma and acute lymphoblastic ... Most gastrointestinal stromal tumors express KIT, which can be detected by immunohistochemistry. Many proteins shown to be ... Gold JS, Dematteo RP (August 2006). "Combined Surgical and Molecular Therapy: The Gastrointestinal Stromal Tumor Model". Ann. ... Many tumors are hormone dependent. The presence of hormone receptors can be used to determine if a tumor is potentially ...
gastrointestinal stromal tumors". Cancer Genet. Cytogenet. 135 (1): 1-22. PMID 12072198. doi:10.1016/S0165-4608(02)00546-0.. ... Lasota J, Miettinen M (2007). „KIT and PDGFRA mutations in gastrointestinal stromal tumors (GISTs)". Semin Diagn Pathol. 23 (2 ... Sandberg AA, Bridge JA (2002). „Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors. ...
... gastrointestinal stromal tumors, glioblastoma, and neuroblastoma. Nedd9 expression may be important for recovery from stroke. ... "Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells". Cancer Biol. Ther. 8 (8): 683-8. doi: ... Lu R, Ji Z, Li X, Zhai Q, Zhao C, Jiang Z, Zhang S, Nie L, Yu Z (2014). "miR-145 functions as tumor suppressor and targets two ... Interaction of NEDD9 with Aurora A kinase may also play a role in tumor invasion. NEDD9 binds to and regulates acetylation of ...
"Ménétrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach". Journal of Clinical ... Its potential use as a prognostic biomarker in various tumors, like gastric carcinoma. or melanoma has been suggested. Elevated ... "Immunoreactivity of transforming growth factor alpha in the normal adult gastrointestinal tract". Gut. 33 (5): 628-31. doi: ...
"MicroRNA-494 downregulates KIT and inhibits gastrointestinal stromal tumor cell proliferation". Clin. Cancer Res. 17 (24): 7584 ...
On February 25, 2013 the US FDA expanded the approved use to treat patients with advanced gastrointestinal stromal tumors that ... "FDA approves Stivarga for advanced gastrointestinal stromal tumors". 25 Feb 2013. CONSIGN, CONCUR Confirm Efficacy of ... Since 2009 it was studied as a potential treatment option in multiple tumor types. By 2015 it had 2 US approvals for advanced ... In a clinical study with 199 patients regorafenib treated patients had a delay in tumor growth (progression-free survival) that ...
2010). "Immunohistochemistry for SDHB divides gastrointestinal stromal tumors (GISTs) into 2 distinct types". Am. J. Surg. ... The penetrance of the gene is often reported as 77% by age 50[12] (i.e. 77% of carriers will have at least one tumour by the ... Tumor formation generally follows the Knudson "two hit" hypothesis. The first copy of the gene is mutated in all cells, however ... Mutations causing disease have been seen in exons 1 through 7, but not 8. As with the SDHC and SDHD genes, SDHB is a tumor ...
2007). "Menetrier disease and gastrointestinal stromal tumors: hyperproliferative disorders of the stomach". J Clin Invest. 117 ... A small amount of gastrointestinal bleeding may occur, which is typically due to superficial mucosal erosions; large volume ...
ISBN 978-0-19-957493-3. p.581 Miettinen M, Lasota J (2006). "Gastrointestinal stromal tumors: review on morphology, molecular ... ICCs are thought to be the cells from which gastrointestinal stromal tumours (GISTs) arise. Also, abnormalities in the ICC ... The interstitial cell of Cajal (ICC) is a type of interstitial cell found in the gastrointestinal tract. There are different ... Sanders K, Koh S, Ward S (2006). "Interstitial cells of cajal as pacemakers in the gastrointestinal tract". Annu Rev Physiol. ...
"Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas". Proceedings of ...
"Gene expression signatures and response to imatinib mesylate in gastrointestinal stromal tumor." Molecular cancer therapeutics ...
Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast ... cancer, colon cancer, and tumors of the female genital tract may metastasize to the appendix. Small carcinoids (. ...
Risk of recurrence of gastrointestinal stromal tumour after surgery[..] - 1 March 2012 The Lancet Oncology Vol. 13, Issue 3, ... 6 pp 538-47 Kajo, Zúbor, Plank,: Tumor-like manifestation of endosalpingiosis in uterus: a case report. (2005) Pathology ...
Gonzalez RS, Carlson G, Page AJ, Cohen C (July 2011). "Gastrointestinal stromal tumor markers in cutaneous melanomas: ... Gastrointestinal stromal tumor), PSA (Prostate Specific Antigen) (Prostate Cancer), S100 (Melanoma), and many others. Mutant ... a marker indicating a gastrointestinal stromal tumor (GIST) will likely respond to imatinib treatment; and mutations in the ... "Circulating Levels of Soluble KIT Serve as a Biomarker for Clinical Outcome in Gastrointestinal Stromal Tumor Patients ...
KIT (KIT Piebaldism, Gastrointestinal stromal tumor). STPK. *AMHR2 (Persistent Müllerian duct syndrome II) ... a pituitary tumour). This will lead to a fall in testosterone or oestrogen levels and infertility.[13][16] ...
This forum is for help, questions and support regarding Gastrointestinal Stromal Tumor Community (GIST) ... MedHelps Gastrointestinal Stromal Tumor Community (GIST) Help Forum. ... Gastrointestinal Stromal Tumor Community (GIST) Community. WELCOME TO THE COMMUNITY: This Patient-To-Patient Community is for ... My husband has been on gleevec since a very large tumor was removed 5 years ago. His latest CT scan showed 4 tumors, one being ...
... gastrointestinal stromal tumors (GISTs) and a number of other malignancies. It is the first member of a new class of agents ... It is used for the treatment of metastatic colorectal cancer and advanced gastrointestinal stromal tumours. FDA approved on ...
Upregulation of p53 by MDM2 inhibitors has been shown to induce apoptosis in p53 wildtype tumors. Analyzing a series of 62 ... has greatly improved the treatment of metastatic gastrointestinal stromal tumors (GIST). IM exhibits strong antiproliferative ... Gastrointestinal stromal tumors (GISTs) are the most frequent mesenchymal neoplasms of the gastrointestinal tract [1] and are ... 1. Miettinen M, Sarlomo-Rikala M, Lasota J (1999) Gastrointestinal stromal tumors: recent advances in understanding of their ...
Patients with gastrointestinal stromal tumors faced an increased risk for developing additional cancers before and after their ... Gastrointestinal stromal tumors (GISTs), the most common mesenchymal tumor of the GI tract, have always captured the ... Patients with gastrointestinal stromal tumors faced an increased risk for developing additional cancers before and after their ... "Only 5% of patients with gastrointestinal stromal tumors have a hereditary disorder that predisposes them to develop multiple ...
Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the ... The therapeutic approach to locally developed gastrointestinal stromal tumors is surgical resection, either with open or ... They are usually located in the upper gastrointestinal track. These tumors are typically defined by the expression of c-KIT ( ... CD117) and CD34 proteins in the tumor cells. A small percentage of these tumors is negative for c-KIT. The neoplasms are ...
This book provides a comprehensive and up-to-date overview of gastrointestinal stromal tumors (GISTs). ... ... This book provides a comprehensive and up-to-date overview of gastrointestinal stromal tumors (GISTs).. GISTs represent the ... where has there is and inherently high prevalence of gastrointestinal cancers.. Each expert author elucidates the cutting-edge ... most common mesenchymal neoplasms arising within the gastrointestinal tract. The causative gene of this disease was originally ...
The most common submucosal tumor of the GIT is the gastrointestinal stromal tumor. It presents late due to its extra luminal ... The most common submucosal tumor of the GIT is the gastrointestinal stromal tumor. It presents late due to its extra luminal ...
... associated with a gastrointestinal stromal tumour within the apex of the diverticulum. The absence of necrosis and a low ... We discuss the management of a gastrointestinal tumour within the diverticulum. A 59-year-old Caucasian man presented with ... perforation and haemorrhage of a Meckels diverticulum leading to the incidental finding of a gastrointestinal stromal tumour ... This article reviews this common congenital abnormality and discusses the management of a gastrointestinal tumour. Meckels ...
... gastrointestinal stromal tumor - PharmQD. Bowtrol Probiotic improve gastrointestinal function & intestinal good bacterial ... Gastrointestinal- Stromal-Tumor-(GIST)) Gastrointestinal Stromal Tumor (GIST) GIST (gastrointestinal stromal tumor) is a ... www.cancer.org/cancer/gastrointestinal-stro mal-tumor.html) Gastrointestinal stromal tumors. Gastrointestinal stromal tumors ( ... stro mal_tumors) Gastrointestinal Stromal Tumor (GIST) What are gastrointestinal stromal tumors? Cancer starts when cells in ...
"A case of malignant gastrointestinal stromal tumor of the uncommitted type",. abstract = "We report a case of gastrointestinal ... Hayama, S, Yabiku, T, Takenouchi, N, Kato, H & Nishihara, H 2001, A case of malignant gastrointestinal stromal tumor of the ... Hayama, S., Yabiku, T., Takenouchi, N., Kato, H., & Nishihara, H. (2001). A case of malignant gastrointestinal stromal tumor of ... A case of malignant gastrointestinal stromal tumor of the uncommitted type. In: Japanese Journal of Gastroenterological Surgery ...
Gastrointestinal stromal tumors (GIST) are the most common soft tissue sarcoma of the gastrointestinal tract, resulting most ... N2 - Gastrointestinal stromal tumors (GIST) are the most common soft tissue sarcoma of the gastrointestinal tract, resulting ... AB - Gastrointestinal stromal tumors (GIST) are the most common soft tissue sarcoma of the gastrointestinal tract, resulting ... abstract = "Gastrointestinal stromal tumors (GIST) are the most common soft tissue sarcoma of the gastrointestinal tract, ...
N2 - Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. ... AB - Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. ... Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal tract. ... abstract = "Background: Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumor of the gastrointestinal ...
The gastrointestinal stromal tumor is the most common mesenchymal neoplasm of the gastrointestinal tract. The gastrointestinal ... The Primary Extra-gastrointestinal Stromal Tumor of Pleura: A Case Report and a Literature Review. Author. 하태경. Keywords. ... prognostic factors and outcomes of gastrointestinal stromal tumors are well known, those of extragastrointestinal stromal ... gastrointestinal stromal tumor; pleural cavity; KIT; DOG-1; Thoracic-Mediastinum; pleura. Issue Date. 2013-12. Publisher. ...
This trial will investigate the efficacy and tolerability of palbociclib in patients with advanced gastrointestinal stromal ... Efficacy and Safety of PD-0332991 in Patients With Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and ... Efficacy and Safety of PD-0332991 in Patients With Advanced Gastrointestinal Stromal Tumors Refractory to Imatinib and ...
T1 - Impact of rechallenge with imatinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib and ... Impact of rechallenge with imatinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib and ... Impact of rechallenge with imatinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib and ... Impact of rechallenge with imatinib in patients with advanced gastrointestinal stromal tumor after failure of imatinib and ...
Ewing Sarcoma Family of Tumors Treatment. *Gastrointestinal Stromal Tumors Treatment. *Kaposi Sarcoma Treatment ... Tumor sizes. The size of a tumor may be compared to the size of a pea (1 cm), peanut (2 cm), grape (3 cm), walnut (4 cm), lime ... The metastatic tumor is the same type of cancer as the primary tumor. For example, if soft tissue sarcoma spreads to the lung, ... Mohs microsurgery: A procedure in which the tumor is cut from the skin in thin layers. During surgery, the edges of the tumor ...
GIST is the English acronym for Gastro Intestinal Stromal Tumor It is a mesenchymal tumor, generally with immunohistochemistry ... Lopes J.M. (2017) Gastrointestinal Stromal Tumor. In: Carneiro F., Chaves P., Ensari A. (eds) Pathology of the Gastrointestinal ... Miettinnen, M., Fetsch, J. F., Sobin, L. H., & Lasota, J. (2006). Gastrointestinal stromal tumors in patients with ... Surgical margin status and prognosis of gastrointestinal stromal tumor. World Journal of Surgery, 32, 2375-2382.PubMedGoogle ...
... is a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. Explore symptoms ... medlineplus.gov/genetics/condition/gastrointestinal-stromal-tumor/ Gastrointestinal stromal tumor. ... A gastrointestinal stromal tumor (GIST) is a type of tumor that occurs in the gastrointestinal tract, most commonly in the ... Germline-activating mutation in the kinase domain of KIT gene in familial gastrointestinal stromal tumors. Am J Pathol. 2000 ...
... and it may also help patients with earlier stage tumors. ... Targeted Therapy for Gastrointestinal Stromal Tumor. Some drugs ... Radiation Therapy for Gastrointestinal Stromal Tumor * Treatment Choices for Gastrointestinal Stromal Tumor Based on Tumor ... Radiation Therapy for Gastrointestinal Stromal Tumor * Treatment Choices for Gastrointestinal Stromal Tumor Based on Tumor ... Treating Gastrointestinal Stromal Tumors * Surgery for Gastrointestinal Stromal Tumor * Ablation and Embolization to Treat ...
The exact cause of these tumors is unknown, but there may be a genetic link. As with many types of tumors, the symptoms of a ... Treatment ranges from surgically removing the whole tumor and surrounding tissues to receiving targeted therapy. If the tumor ... About 4,000 to 60,000 people are diagnosed with this type of tumor each year in the United States. While GISTs are serious and ... If the GIST is cancerous, your doctor will stage the tumor. This allows them to find the best treatment plan for you. ...
However, primary tumors may also occur outside of the gastrointestinal tract, in other intra-abdominal locations, especially in ... Some tumors are dominated by epithelioid cells or contain a mixture of spindle and epithelioid morphologies. Primary GISTs in ... Common mesenchymal neoplasms arising in the gastrointestinal tract, most often in the stomach. They are histologically, ... the gastrointestinal tract commonly metastasize in the omentum and mesenteries, often as multiple nodules. ...
If you or someone you know has just been diagnosed with a gastrointestinal stromal tumor (GIST), this short, simple guide can ... If You Have a Gastrointestinal Stromal Tumor (GIST). What are GISTs?. Cancer can start any place in the body. A GIST ( ... This test can show how far a tumor has grown into the wall of the GI tract. It can also help show if the tumor has reached ... Gastrointestinal (GI) tract: The long pathway inside the body through which food passes. It includes hollow organs such as the ...
Center has one of the largest and most experienced centers in New England for the treatment of gastrointestinal stromal tumor ... Gastrointestinal Stromal Tumor (GIST) Treatment Program. The Mass General Cancer Center has one of the largest and most ... Our multidisciplinary team of gastrointestinal stromal tumor cancer (GIST) specialists provides individualized care and ... Rapid diagnosis and staging of all biopsied tumors by pathologists who special in stromal tumors ...
Gastrointestinal Stromal Tumor (GIST) News and Research. RSS Gastrointestinal Stromal Tumor (GIST) is a type of tumor that ... gastrointestinal stromal tumor (GIST) and pancreatic neuroendocrine tumor (PNET). ... Gastrointestinal Stromal Tumor (GIST) Treatment. *Gastrointestinal Stromal Tumor (GIST) Causes. *Gastrointestinal Stromal Tumor ... The monoclonal antibody SR1 can significantly inhibit gastrointestinal stromal tumor cell growth, report researchers in the ...
Features of the Index Patients Tumor and D3 Expression across Genetic Subtypes of Gastrointestinal Stromal Tumor (GIST) ... Thyroid hormone inactivation in gastrointestinal stromal tumors.. Maynard MA1, Marino-Enriquez A, Fletcher JA, Dorfman DM, Raut ... Gastrointestinal stromal tumors (GISTs) are resistant to traditional chemotherapy but are responsive to the tyrosine kinase ... Thyroid hormone inactivation in gastrointestinal stromal tumors. [N Engl J Med. 2014] ...
  • Multivariate analysis demonstrated that tumor size ≥10 cm was associated with higher recurrence rates (P = .032) and was the only independent poor prognostic factor for survival (P = .020). (ncku.edu.tw)
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