Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.
The separation and isolation of tissues for surgical purposes, or for the analysis or study of their structures.
An autosomal dominant disorder of CONNECTIVE TISSUE with abnormal features in the heart, the eye, and the skeleton. Cardiovascular manifestations include MITRAL VALVE PROLAPSE, dilation of the AORTA, and aortic dissection. Other features include lens displacement (ectopia lentis), disproportioned long limbs and enlarged DURA MATER (dural ectasia). Marfan syndrome is associated with mutations in the gene encoding fibrillin, a major element of extracellular microfibrils of connective tissue.
Endoscopic examination, therapy or surgery of the interior of the stomach.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
Tumors or cancer of the STOMACH.
All tumors in the GASTROINTESTINAL TRACT arising from mesenchymal cells (MESODERM) except those of smooth muscle cells (LEIOMYOMA) or Schwann cells (SCHWANNOMA).
A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
BENZOIC ACID amides.
A family of 6-membered heterocyclic compounds occurring in nature in a wide variety of forms. They include several nucleic acid constituents (CYTOSINE; THYMINE; and URACIL) and form the basic structure of the barbiturates.
Treatment of disease by inserting needles along specific pathways or meridians. The placement varies with the disease being treated. It is sometimes used in conjunction with heat, moxibustion, acupressure, or electric stimulation.
The occupational discipline of the traditional Chinese methods of ACUPUNCTURE THERAPY for treating disease by inserting needles along specific pathways or meridians.
Designated locations along nerves or organ meridians for inserting acupuncture needles.
Analgesia produced by the insertion of ACUPUNCTURE needles at certain ACUPUNCTURE POINTS on the body. This activates small myelinated nerve fibers in the muscle which transmit impulses to the spinal cord and then activate three centers - the spinal cord, midbrain and pituitary/hypothalamus - to produce analgesia.
A procedure in which a laparoscope (LAPAROSCOPES) is inserted through a small incision near the navel to examine the abdominal and pelvic organs in the PERITONEAL CAVITY. If appropriate, biopsy or surgery can be performed during laparoscopy.
Works about pre-planned studies of the safety, efficacy, or optimum dosage schedule (if appropriate) of one or more diagnostic, therapeutic, or prophylactic drugs, devices, or techniques selected according to predetermined criteria of eligibility and observed for predefined evidence of favorable and unfavorable effects. This concept includes clinical trials conducted both in the U.S. and in other countries.
Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.
A type of asbestos that occurs in nature as the dihydrate of magnesium silicate. It exists in two forms: antigorite, a plated variety, and chrysotile, a fibrous variety. The latter makes up 95% of all asbestos products. (From Merck Index, 11th ed, p.893)
A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)
A lavender, acid-resistant asbestos.
A class of asbestos that includes silicates of magnesium, iron, calcium, and sodium. The fibers are generally brittle and cannot be spun, but are more resistant to chemicals and heat than ASBESTOS, SERPENTINE. (From Hawley's Condensed Chemical Dictionary, 11th ed)
A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
The portion of the GASTROINTESTINAL TRACT between the PYLORUS of the STOMACH and the ILEOCECAL VALVE of the LARGE INTESTINE. It is divisible into three portions: the DUODENUM, the JEJUNUM, and the ILEUM.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
The section of the alimentary canal from the STOMACH to the ANAL CANAL. It includes the LARGE INTESTINE and SMALL INTESTINE.
Cold-blooded, air-breathing VERTEBRATES belonging to the class Reptilia, usually covered with external scales or bony plates.
The valve, at the junction of the CECUM with the COLON, that guards the opening where the ILEUM enters the LARGE INTESTINE.
The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.
The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.

A prospective randomized study of megestrol acetate and ibuprofen in gastrointestinal cancer patients with weight loss. (1/1704)

The use of megestrol acetate in the treatment of weight loss in gastrointestinal cancer patients has been disappointing. The aim of the present study was to compare the combination of megestrol acetate and placebo with megestrol acetate and ibuprofen in the treatment of weight loss in such patients. At baseline, 4-6 weeks and 12 weeks, patients underwent measurements of anthropometry, concentrations of albumin and C-reactive protein and assessment of appetite, performance status and quality of life using EuroQol-EQ-5D and EORTC QLQ-C30. Thirty-eight and 35 patients (median weight loss 18%) were randomized to megestrol acetate/placebo or megestrol acetate/ibuprofen, respectively, for 12 weeks. Forty-six (63%) of patients failed to complete the 12-week assessment. Of those evaluable at 12 weeks, there was a decrease in weight (median 2.8 kg) in the megestrol acetate/placebo group compared with an increase (median 2.3 kg) in the megestrol acetate/ibuprofen group (P<0.001). There was also an improvement in the EuroQol-EQ-5D quality of life scores of the latter group (P<0.05). The combination of megestrol acetate/ibuprofen appeared to reverse weight loss and appeared to improve quality of life in patients with advanced gastrointestinal cancer. Further trials of this novel regimen in weight-losing patients with hormone-insensitive cancers are warranted.  (+info)

Predicting delayed anxiety and depression in patients with gastrointestinal cancer. (2/1704)

The aim of this study was to examine the possibility of predicting anxiety and depression 6 months after a cancer diagnosis on the basis of measures of anxiety, depression, coping and subjective distress associated with the diagnosis and to explore the possibility of identifying individual patients with high levels of delayed anxiety and depression associated with the diagnosis. A consecutive series of 159 patients with gastrointestinal cancer were interviewed in connection with the diagnosis, 3 months (non-cured patients only) and 6 months later. The interviews utilized structured questionnaires assessing anxiety and depression [Hospital Anxiety and Depression (HAD) scale], coping [Mental Adjustment to Cancer (MAC) scale] and subjective distress [Impact of Event (IES) scale]. Patient anxiety and depression close to the diagnosis were found to explain approximately 35% of the variance in anxiety and depression that was found 6 months later. The addition of coping and subjective distress measures did little to improve that prediction. A model using (standardized) cut-off scores of moderate to high anxiety, depression (HAD) and intrusive thoughts (IES subscale) close to the diagnosis to identify patients at risk for delayed anxiety and depression achieved a sensitivity of 75% and a specificity of 98%. Levels of anxiety and depression at diagnosis predicted a similar status 6 months later. The results also indicated that the HAD scale in combination with the IES intrusion subscale may be used as a tool for detecting patients at risk of delayed anxiety and depression.  (+info)

Management and outcome of patients undergoing surgery after acute upper gastrointestinal haemorrhage. Steering Group for the National Audit of Acute Upper Gastrointestinal Haemorrhage. (3/1704)

Most patients with acute upper gastrointestinal haemorrhage are managed conservatively or with endoscopic intervention but some ultimately require surgery to arrest the haemorrhage. We have conducted a population-based multicentre prospective observational study of management and outcomes. This paper concerns the subgroup of 307 patients who had an operation because of continued or recurrent haemorrhage or high risk of further bleeding. The principal diagnostic group was those with peptic ulcer. Of 2071 patients with peptic ulcer presenting with acute haemorrhage, 251 (12%) had an operative intervention with a mortality of 24%. In the non-operative group mortality was 10%. The operative intervention rate increased with risk score, ranging from 0% in the lowest risk categories to 38% in the highest. Much of the discrepancy between operative and non-operative mortality was explainable by case mix; however, for high-risk cases mortality was significantly higher in the operated group. In 78% of patients who underwent an operation for bleeding peptic ulcer there had been no previous attempt at endoscopic haemostasis. For patients admitted to surgical units, the operative intervention rate was about four times higher than for those admitted under medical teams. In patients with acute upper gastrointestinal haemorrhage operative intervention is infrequent and largely confined to the highest-risk patients. The continuing high mortality in surgically treated patients is therefore to be expected. The reasons for the low use of endoscopic treatment before surgery are not revealed by this study, but wider use of such treatments might further reduce the operative intervention rate. Physicians and surgeons have not yet reached consensus on who needs surgery and when.  (+info)

Mutations of c-kit JM domain are found in a minority of human gastrointestinal stromal tumors. (4/1704)

The c-kit gene encodes a transmembrane receptor kinase (KIT) which is expressed in the majority of human gastrointestinal stromal tumors (GISTs), a subtype of gastrointestinal mesenchymal neoplasms. A previous study identified mutations in the juxtamembrane (JM) domain of c-kit in five of six GISTs (Science 279: 577, 1998). To better define the frequency and spectrum of c-kit gene mutations in mesenchymal neoplasms of the GI tract that had been characterized for KIT protein expression, we examined archived tissue samples for mutations in the JM domain by PCR amplification and DNA sequencing. c-kit JM domain mutations were found in nine of 56 mesenchymal tumors (46 GISTs, eight leiomyomas, two leiomyosarcomas) and occurred exclusively in GISTs (21%). Seven of the nine mutations consisted of intragenic deletions of one to 19 codons. There was one insertion mutation that added 12 codons and one missense mutation (Val560Asp). None of the mutations disrupted the downstream reading frame of the gene. The single missense mutation (Val560Asp) is very similar to the only other missense mutation reported in GISTs (Val599Asp). Of the 46 GISTs, 43 were strongly positive for KIT protein expression and negative for diffuse expression of desmin. Neither KIT expression nor gene mutations were found in gastrointestinal leiomyomas or leiomyosarcomas. We conclude that mutation of the c-kit JM domain does not occur in gastrointestinal mesenchymal neoplasms with well developed-smooth muscle differentiation, and is restricted to GISTs. However, since these mutations are only found in a minority of GISTs, further investigation into the mechanisms of c-kit gene activation in this group of neoplasms is warranted.  (+info)

Tumorigenesis in Mlh1 and Mlh1/Apc1638N mutant mice. (5/1704)

An3 1 KAL I MutL homologue 1 (MLH1) is a member of the family of proteins required for DNA mismatch repair. Germ-line mutations in MLH1 lead to the cancer susceptibility syndrome hereditary nonpolyposis colorectal cancer (HNPCC). We generated mice carrying a null mutation in the Mlh1 gene. We showed that mice heterozygous and homozygous for the Mlh1 gene are predisposed to developing tumors of the gastrointestinal (GI) tract, lymphomas, and a number of other tumor types. We also examined the role of adenomatous polyposis coli gene (Apc) gene mutations in the GI tumors of Mlh1 mutant mice by different methods and showed that the GI tumors in Mlh1 mice express little or no adenomatous polyposis coli protein. When an Apc gene mutation was bred into the Mlh1 mutant mice, the GI tumor incidence increased 40-100-fold. The wild-type Apc allele in these tumors was found to contain mutations. Together, these results show that we have developed two mouse models for human HNPCC and that the mechanisms of tumor development in the GI tract of these mice involve loss of Apc gene function in a manner very similar to that seen in the GI tumors of HNPCC.  (+info)

Review article: current status of gastrointestinal carcinoids. (6/1704)

Carcinoid tumours are enigmatic, slow growing malignancies which occur most frequently (74%) in the gastrointestinal tract. In recent years, it has become apparent that the term 'carcinoid' represents a wide spectrum of different neoplasms originating from a variety of different neuroendocrine cell types. Carcinoid lesions are usually identified histologically by their affinity for silver salts, by general neuroendocrine markers, or more specifically by immunocytochemistry using antibodies against their specific cellular products. Within the gut, the most frequent sites are the small bowel (29%), the appendix (19%) and rectum (13%). Clinical manifestations are often vague or absent. Nevertheless, in approximately 10% of patients the tumours secrete bioactive mediators which may engender various elements of characteristic carcinoid syndrome. In many instances the neoplasms are detected incidentally at the time of surgery for other gastrointestinal disorders. The tendency for metastatic spread correlates with tumour size, and is substantially higher in lesions larger than 2.0 cm. An association with noncarcinoid neoplasms is ascribed in 8-17% of lesions. Treatment consists of radical surgical excision of the tumour, although gastric (type I and II) and rectal carcinoids may be managed with local excision. Overall 5-year survival is excellent for carcinoids of the appendix (86%) and rectum (72%), whereas small intestinal (55%), gastric (49%) and colonic carcinoids (42%) exhibit a far worse prognosis.  (+info)

Treatment of upper abdominal malignancies with organ cluster procedures. (7/1704)

Upper abdominal exenteration for upper abdominal malignancies was carried out in 15 patients with removal of the liver, spleen, pancreas, duodendum, all or part of the stomach, proximal jejunum and ascending and transverse colon. Organ replacement was with the liver, pancreas and duodenum plus, in some cases, a short segment of jejunum. Eleven of the 15 patients survived for more than 4 months; 2 died, after 61/2 and 10 months, of recurrent tumor. Of the 9 patients who are surviving after 61/2 to 14 months, recurrent tumor is suspected in only 1 and proven in none. Four patients with sarcomas and carcinoid tumors (2 each) have had no recurrences. The other 5 survivors had duct cell cancers (3 examples), a cholangiocarcinoma (1 example), and a hepatoma (1 example). The experience so far supports further cautious trials with this drastic cancer operation.  (+info)

Enteral nutritional supplementation with key nutrients in patients with critical illness and cancer: a meta-analysis of randomized controlled clinical trials. (8/1704)

OBJECTIVE: To conduct a meta-analysis of 11 randomized controlled trials comparing enteral nutritional support supplemented with key nutrients versus standard enteral nutritional support to determine effects on morbidity and mortality rates and hospital stay. BACKGROUND DATA: Recent studies have shown that malnutrition occurs in up to 30% of patients undergoing gastrointestinal surgery, resulting in an increased risk of postoperative complications and death. With the realization that key nutrients can modulate inflammatory, metabolic, and immune processes, enteral nutritional regimens (supplemented with large amounts of key nutrients) have been developed for clinical use. METHODS: Eleven prospective, randomized controlled trials evaluating 1009 patients treated with combinations of key nutrients (Impact, Immun-Aid) were evaluated. Outcome measures examined were the incidences of pneumonia, infectious complications, and death, and length of hospital stay. Meta-analyses were undertaken to obtain the odds ratio and 95% confidence interval for incidences of infectious complications, pneumonia, and death, and the weighted mean difference and 95% confidence interval for length of hospital stay. RESULTS: The provision of nutritional support supplemented with key nutrients to patients with critical illness resulted in a decrease in infectious complications when compared with patients receiving standard nutritional support and a significant reduction in overall hospital stay. Similar results were documented in patients with gastrointestinal cancer. However, there were no differences between patient groups for either pneumonia or death. CONCLUSIONS: This meta-analysis has demonstrated that nutritional support supplemented with key nutrients results in a significant reduction in the risk of developing infectious complications and reduces the overall hospital stay in patients with critical illness and in patients with gastrointestinal cancer. However, there is no effect on death. These data have important implications for the management of such patients.  (+info)

Clinical trial for Gastrointestinal Neoplasm , Clinical Trial on Acupuncture Therapy in Patients With Gastrointestinal Neoplasms Laparoscopic Surgery
TY - JOUR. T1 - Sentinel lymph node mapping with GI cancer. AU - Aikou, Takashi. AU - Kitagawa, Yuko. AU - Kitajima, Masaki. AU - Uenosono, Yoshikazu. AU - Bilchik, Anton J.. AU - Martinez, Steve R.. AU - Saha, Sukamal. PY - 2006/6. Y1 - 2006/6. N2 - Precise evaluation of lymph node status is one of the most important factors in determining clinical outcome in treating gastro-intestinal (GI) cancer. Sentinel lymph node (SLN) mapping clearly has become highly feasible and accurate in staging GI cancer. The lunchtime symposium focused on the present status of SLN mapping for GI cancer. Dr. Kitigawa proposed a new strategy using sentinel node biopsy for esophageal cancer patients with clinically early stage disease. Dr. Uenosono reported on whether the SLN concept is applicable for gastric cancer through his analysis of more than 180 patients with cT1-2, N0 tumors. The detection rate was 95%, the false negative rate of lymph node metastasis including micro-metastasis was 4%, and accuracy was 99% in ...
TY - JOUR. T1 - Cyclophosphamide, methotrexate, 5-fluorouracil (CMF) in advanced gastrointestinal cancer. AU - Scanni, A.. AU - Tomirotti, M.. AU - Margulis, A.. AU - Biraghi, M.. AU - Curtarelli, G.. PY - 1979. Y1 - 1979. N2 - The effectiveness of the cyclophosphamide + methotrexate + 5-fluorouracil schedule (CMF) in 28 patients with advanced gastrointestinal cancer has been studied. No complete remission was obtained; partial remission and objective improvement constituted 56%. The median response period is calculated at a minimum of 12 months, without significant differences between the group of patients previously subjected to palliative canalization surgery and the group of patients not subjected to this operation. The overall median survival time is 10.8 months. On the basis of the data given, the authors conclude by stressing that the CMF combination should be studied more fully in relation to its use in gastrointestinal forms of cancer.. AB - The effectiveness of the cyclophosphamide + ...
Chevrou-Severac H, Eijgelshoven I, Weijers L. Cost-Effectiveness Analysis of Immunonutrition for Upper Gastrointestinal Cancer Patients Undergoing Surgery in British Hospitals. Value Health. 2012 Nov;15(7):A416. Presented at: ISPOR 15th Annual European Congress; November 6, 2012; Berlin, Germany.. ...
RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with fluorouracil and leucovorin in treating patients with advanced gastrointestinal cancer. ...
RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. Giving more than one drug (combination chemotherapy) may kill more tumor cells.. PURPOSE: This phase I trial is studying the side effects and best dose of irinotecan when given together with fluorouracil and leucovorin in treating patients with advanced gastrointestinal cancer. ...
Danbury Hospitals Gastrointestinal (GI) Cancer Program offers a variety plans for the best personalized care. Learn about gastrointestinal (GI) cancer treatment here.
TY - JOUR. T1 - Regulation of β-catenin by t-DARPP in upper gastrointestinal cancer cells. AU - Vangamudi, Bhavatarini. AU - Zhu, Shoumin. AU - Soutto, Mohammed. AU - Belkhiri, Abbes. AU - El-Rifai, Wael. PY - 2011/3/29. Y1 - 2011/3/29. N2 - Background: Truncated dopamine and cyclic-AMP-regulated phosphoprotein (t-DARPP) is frequently overexpressed in gastrointestinal malignancies. In this study, we examined the role of t-DARPP in regulating β-catenin.Results: The pTopFlash construct that contains multiple TCF/LEF-binding sites was used as a measure of β-catenin/TCF transcription activity. Gastric (AGS, MKN28) and esophageal (FLO-1) adenocarcinoma cancer cell lines that lack t-DARPP expression were utilized to establish stable and transient in vitro expression models of t-DARPP. The expression of t-DARPP led to a significant induction of the pTOP reporter activity, indicative of activation of β-catenin/TCF nuclear signaling. Immunofluorescence assays supported this finding and showed ...
Prospective analyses have yet to uncover a consistent relationship between vitamin D status and incidence and mortality of rarer cancers including esophageal and upper gastrointestinal cancers. We searched PubMed for literature about the epidemiology of upper gastrointestinal cancers and vitamin D published over the last decade and then summarized and critiqued the results of these studies in this review. The search yielded nine relevant studies. Overall, no consistent relationship was reported between serum vitamin D levels or a surrogate and upper gastrointestinal cancers. Four studies reported negative correlations between vitamin D status and upper gastrointestinal cancer, three reported positive correlations, one reported no correlation, and one reported both positive and negative correlations. No relationship has been established on the basis of epidemiologic data, but studies examining sun exposure consistently report an inverse association with esophageal cancer. The current literature ...
Title:Combined Therapy for Gastrointestinal Carcinomas: Exploiting Synergies Between Gene Therapy and Classical Chemo-Radiotherapy. VOLUME: 15 ISSUE: 2. Author(s):Mariana Malvicini, Jorge B. Aquino and Guillermo Mazzolini. Affiliation:Liver Unit, Facultad de Ciencias Biomedicas. Universidad Austral, Avenida Presidente Peron 1500 (B1629ODT) Derqui-Pilar, Buenos Aires, Argentina.. Keywords:Gastrointestinal, cancer, gene therapy, combined strategies, chemotherapy, radiotherapy, immunotherapy.. Abstract:Surgical resection is the only curative option for patients with gastrointestinal carcinomas. Unfortunately, the majority of patients are diagnosed in advanced stages when surgery is not possible. Moreover, the incidence and mortality for certain type of tumors such as hepatocellular carcinoma or pancreatic cancer are steadily increasing worldwide. In spite of the advances in the development of molecular targeted therapies for cancer, the impact on patient survival has been rather limited. It is ...
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In this presentation from the 2017 Great Debates & Updates in GI Malignancies, Dr. Zsofia K. Stadler assesses the state of knowledge regarding hereditary syndromes in GI cancer, and proffers who should be tested and why. Earn CME Credit for a related activity: http://elc.imedex.com/ELC/S... © 2017 Imedex, LLC.
Tumor-resident lymphocytes can mount a response against neoantigens expressed in microsatellite-stable gastrointestinal (GI) cancers, and adoptive transfer of neoantigen-specific lymphocytes has demonstrated antitumor activity in selected patients. However, whether peripheral blood could be used as an alternative minimally invasive source to identify lymphocytes targeting neoantigens in patients with GI cancer with relatively low mutation burden is unclear. We used a personalized high-throughput screening strategy to investigate whether PD-1 expression in peripheral blood could be used to identify CD8+ or CD4+ lymphocytes recognizing neoantigens identified by whole-exome sequencing in 7 patients with GI cancer. We found that neoantigen-specific lymphocytes were preferentially enriched in the CD8+PD-1+/hi or CD4+PD-1+/hi subsets, but not in the corresponding bulk or PD-1- fractions. In 6 of 7 individuals analyzed we identified circulating CD8+ and CD4+ lymphocytes targeting 6 and 4 neoantigens, ...
Good morning. So we are going to talk about genetic susceptibility to GI cancers today. As Dr. Brand just said, the first part will be about colon syndromes and then hell talk to you a little bit about pancreatic syndromes as well. So this is interactive, Im going to give you guys some case scenarios and ask you to tell me what you think the genetic syndrome is. So please participate.. All right. So just a little bit of an overview for you first. This is information that you may already know but just if you are seeing a patient and thinking about whether or not they may have a hereditary predisposition to cancer these are the sorts of things that you would want to keep in mind. So young age of cancer diagnosis, typically before age 50; if there are multiple people that have either the same or genetically related types of cancer; people with more than one cancer diagnosis; people with unusual types of cancer; and then of course from a colon perspective people who have lots and lots of colon ...
Global Gastrointestinal Cancer Drugs Market Professional Survey Report 2017 1 Industry Overview of Gastrointestinal Cancer Drugs 1.1 Definition and Specifications of Gastrointestinal Cancer Drugs 1.1.1 Definition of Gastrointestinal Cancer Drugs 1.1.2 Specifications of Gastrointestinal Cancer Drugs 1.2 Classification of Gastrointestinal Cancer Drugs 1.2.1 Immunotherapy 1.2.2 Chemotherapy 1.2.3 Targeted Therapy 1.2.4 Hormone Therapy 1.2.5 Adjuvant Chemotherapy 1.2.6 Radiation Therapy 1.2.7 Others 1.3 Applications of Gastrointestinal Cancer Drugs 1.3.1 Hospitals 1.3.2 Specialized Cancer Treatment Centers 1.3.3 Clinics 1.3.4 Ambulatory Surgical Centers 1.4 Market Segment by Regions 1.4.1 North America 1.4.2 China 1.4.3 Europe 1.4.4 Southeast Asia 1.4.5 Japan 1.4.6 India 2 Manufacturing Cost Structure Analysis of Gastrointestinal Cancer Drugs 2.1 Raw Material and Suppliers 2.2 Manufacturing Cost Structure Analysis of Gastrointestinal Cancer Drugs 2.3 Manufacturing Process Analysis of ...
Objectives We investigated whether using demographic characteristics and alarm symptoms can accurately predict cancer in patients with dyspepsia in Iran, where upper GI cancers and H. pylori infection are common. Methods All consecutive patients referred to a tertiary gastroenterology clinic in Tehran, Iran, from 2002 to 2009 were invited to participate in this study. Each patient completed a standard questionnaire and underwent upper gastrointestinal endoscopy. Alarm symptoms included in the questionnaire were weight loss, dysphagia, GI bleeding, and persistent vomiting. We used logistic regression models to estimate the diagnostic value of each variable in combination with other ones, and to develop a risk-prediction model. Results A total of 2,847 patients with dyspepsia participated in this study, of whom 87 (3.1%) had upper GI malignancy. Patients reporting at least one of the alarm symptoms constituted 66.7% of cancer patients compared to 38.9% in patients without cancer (p|0.001). Esophageal
Abstract. Background & Aims: Low-molecular-weight citrus pectin (LCP) is a complex polysaccharide that displays abundant galactosyl (i.e., sugar carbohydrate) residues. In this study, we evaluated the anti-tumor properties of LCP that lead to Bcl-xL -mediated dampening of apoptosis in gastrointestinal cancer cells.. Methods: We used AGS gastric cancer and SW-480 colorectal cancer cells to elucidate the effects of LCP on cell viability, cell cycle and apoptosis in cultured cells and tumor xenografts.. Results: Significantly decreased cell viabilities were observed in LCP treated AGS and SW-480 cells (P,0.05). Cell cycle-related protein expression, such as Cyclin B1, was also decreased in LCP treated groups as compared to the untreated group. The AGS or SW-480 cell-line tumor xenografts were significantly smaller in the LCP treated group as compared the untreated group (P,0.05). LCP treatment decreased Galectin-3 (GAL-3) expression levels, which is an important gene in cancer metastasis that ...
Lower Gastrointestinal Malignancies|Lower Gastrointestinal MalignanciesThis issue of Radiation Medicine Rounds focuses on lower gastrointestinal malignancies.
A review and meta-analysis appearing in the April 2018 issue of the journal Medicine concluded that supplementation with omega-3 polyunsaturated fatty acids early in the treatment of gastrointestinal cancer can boost immune function and reduce inflammation.
Gastrointestinal cancer symptoms vary widely because cancer can affect the esophagus, stomach, liver and many other parts of the GI system. Read more here.
Contrast Media; Gastrointestinal Neoplasms; Gastrointestinal Stromal Tumors; Humans; Molecular Targeted Therapy; Positron-Emission Tomography; Tomography, X-Ray Computed ...
RATIONALE: Drugs used in chemotherapy, such as irinotecan, fluorouracil, and leucovorin, work in different ways to stop the growth of tumor cells, eithe
The therapeutic landscape in oncology has undergone momentous changes in recent years. The treatment options for gastrointestinal (GI) cancers, in particular, have increased with the introduction of novel pharmacological and other treatment modalities. Researchers have gleaned important insights into the molecular biology, pathophysiology and key features of the most prevalent GI cancers, including colorectal, pancreatic and liver. While these advances have resulted in improvements for many GI cancer patients, the emerging complexities and challenges have necessitated the revision of major U.S ...
Tumor-resident lymphocytes can mount a response against neoantigens expressed in microsatellite-stable gastrointestinal (GI) cancers, and adoptive transfer of neoantigen-specific lymphocytes has demonstrated antitumor activity in selected patients. However, whether peripheral blood could be used as an alternative minimally invasive source to identify lymphocytes targeting neoantigens in patients with GI cancer with relatively low mutation burden is unclear. We used a personalized high-throughput screening strategy to investigate whether PD-1 expression in peripheral blood could be used to identify CD8+ or CD4+ lymphocytes recognizing neoantigens identified by whole-exome sequencing in 7 patients with GI cancer. We found that neoantigen-specific lymphocytes were preferentially enriched in the CD8+PD-1+/hi or CD4+PD-1+/hi subsets, but not in the corresponding bulk or PD-1- fractions. In 6 of 7 individuals analyzed we identified circulating CD8+ and CD4+ lymphocytes targeting 6 and 4 neoantigens, ...
BACKGROUND AND OBJECTIVES: Omega-3 fatty acids are widely used in nutritional support. However, whether parenteral supplementation with ω-3 fatty acids is effective for gastrointestinal cancer patients remains uncertain. This study assessed the effects of this form of parenteral nutrition on immune function and clinical outcomes in postoperative gastrointestinal cancer patients. METHODS AND STUDY DESIGN: We searched Medline, Embase, Scopus, and the reference lists of selected studies to identify randomized controlled trials that compared ω-3 fatty acids with a control, and that included immune indices, infectious complications, or length of hospital stay in the final outcomes ...
In this article I review the association between exposure to carrageenan and the occurrence of colonic ulcerations and gastrointestinal neoplasms in animal models. Although the International Agency for Research on Cancer in 1982 identified sufficient evidence for the carcinogenicity of degraded carrageenan in animals to regard it as posing a carcinogenic risk to humans, carrageenan is still used widely as a thickener, stabilizer, and texturizer in a variety of processed foods prevalent in the Western diet. I reviewed experimental data pertaining to carrageenans effects with particular attention to the occurrence of ulcerations and neoplasms in association with exposure to carrageenan. In addition, I reviewed from established sources mechanisms for production of degraded carrageenan from undegraded or native carrageenan and data with regard to carrageenan intake. Review of these data demonstrated that exposure to undegraded as well as to degraded carrageenan was associated with the occurrence of ...
The human microbiome - defined as the microbial communities that live in and on our bodies - is emerging as a key factor in human diseases. The expanding research field that investigates the role of the...
This phase I trial will investigate MT 111 [MEDI 565; MedImmune], a BiTE antibody, in patients with advanced gastrointestinal cancer. Safety, tolerability and
The Notch signaling pathway is one of the main signaling pathways that mediates direct contact between cells, and is essential for normal development. It regulates various cellular processes, including cell proliferation, apoptosis, migration, invasion, angiogenesis and metastasis. It additionally serves an important function in tumor progression. Non‑coding RNAs mainly include small microRNAs, long non‑coding RNAs and circular RNAs. At present, a large body of literature supports the biological significance of non‑coding RNAs in tumor progression. It is also becoming increasingly evident that cross‑talk exists between Notch signaling and non‑coding RNAs. The present review summarizes the current knowledge of Notch‑mediated gastrointestinal cancer cell processes, and the effect of the crosstalk between the three major types of non‑coding RNAs and the Notch signaling pathway on the fate of gastrointestinal cancer cells ...
TY - JOUR. T1 - p53MVA therapy in patients with refractory gastrointestinal malignancies elevates p53-specific CD8+ T-cell responses. AU - Hardwick, Nicola R.. AU - Carroll, Mary. AU - Kaltcheva, Teodora. AU - Qian, Dajun. AU - Lim, Dean. AU - Leong, Lucille. AU - Chu, Peiguo. AU - Kim, Joseph. AU - Chao, Joseph. AU - Fakih, Marwan. AU - Yen, Yun. AU - Espenschied, Jonathan. AU - Ellenhorn, Joshua D.I.. AU - Diamond, Don J.. AU - Chung, Vincent. PY - 2014/9/1. Y1 - 2014/9/1. N2 - PURPOSE: To conduct a phase I trial of a modified vaccinia Ankara (MVA) vaccine delivering wild-type human p53 (p53MVA) in patients with refractory gastrointestinal cancers.EXPERIMENTAL DESIGN: Three patients were vaccinated with 1.0×10(8) plaque-forming unit (pfu) p53MVA followed by nine patients at 5.6×10(8) pfu. Toxicity was classified using the NCI Common Toxicity Criteria and clinical responses were assessed by CT scan. Peripheral blood samples were collected pre- and post-immunization for immunophenotyping, ...
Reply. We went through this section and sharpen our statements. But, we included a new point into our conclusion since reviewer 1 requested a more critical view on the question: did EV based liquid biopsy make the translational step forward at least from bench to bed side, at least in some diagnostic applications. Unfortunately, not really and actually it is the current Achilles heel of the whole EV based experimental diagnosis. I discussed this in the conclusion citing appropriate references and referring to FDA. Reviewer 3 Report. The review article by Artur et al. EVs as potential new therapeutic tool/target in gastrointestinal and HCC describes and summarizes body of literature on EVs and their involvement in GI cancers and HCC. The field of EVs and their potential role as tumor biomarker and potential therapeutic target in different cancers has received considerable attention in recent years. The authors have accumulated and described literature focused on EVs in GI cancers and HCC. I ...
NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Immunoregulation of Gastrointestinal Carcinogenesis (R01) PA-07-256. NCI
Chronic weight loss may indicate the disease condition known as gastrointestinal neoplasia which is an aggressive cancerous growth within the digestive tract and stomach. - Wag! (formerly Vetary)
TY - JOUR. T1 - The use of DNA fingerprinting to resolve conflicting results in patients with suspected gastrointestinal malignancy. AU - Islam, Sameer. AU - Miller, Ethan D.. AU - Patel, Neal. AU - De Petris, Giovanni. AU - Highsmith, Edward W.. AU - Fleischer, David E.. PY - 2013/3/1. Y1 - 2013/3/1. N2 - GOALS: To underscore the utility of DNA fingerprinting for clarifying disparate results from endoscopic pathologic specimens. BACKGROUND: Occasionally, serially obtained gastrointestinal biopsies may yield inconsistent results. These discrepancies pose a dilemma for gastroenterologists and their patients, especially when malignancy is a consideration. STUDY: Patients referred to our tertiary care center from outside institutions had undergone endoscopically obtained esophageal biopsies showing malignancy, verified by pathologists at both our site and from the referring center. Repeat endoscopic biopsies at our center did not show malignancy. To verify that different sets of biopsies came from ...
Gastrointestinal malignancies may be associated with obesity, defined specifically by increased body-mass index, and based largely on environmental factors rather than genetics. In particular, there seems to be a definite increase in the incidence of both oesophageal and colorectal cancer. Mechanism …
Test your knowledge of head and neck cancers and gastrointestinal cancers with questions from a past edition of ASCO-SEP®, ASCOs self-evaluation program in oncology.
John L. Marshall, MD, chief, Division of Hematology/Oncology, Medstar Georgetown University Hospital director, Otto J. Ruesch Center for the Cure of Gastrointestinal Cancer, discusses the current state of RAS-mutant gastrointestinal (GI) cancers during the 2017 Ruesch Center Symposium.|br /|  
Long-term aspirin use significantly reduced the incidence of many cancers, but was especially protective against gastrointestinal cancers, according to new research presented at UEG Week.“The findings demonstrate that the long-term use of aspirin can reduce the risk of developing many major cancers,” Kelvin Tsoi, PhD, research associate professor of the Stanley Ho Big Data Decision
2. Low-Risk Group Can Avoid Surgery for Locally Advanced Rectal Cancer: A retrospective analysis of 145 stage I-III rectal cancer patients shows that those patients who have a complete response after chemoradiotherapy and chemotherapy had a similar 4-year survival rate regardless of whether they had surgery or opted for surveillance. In general, about 40% of patients with stage I-III disease have disappearance of their tumors after systemic therapy. The 4-year overall survival rate was 91% and 95% in the no surgery and standard surgery groups, respectively. There was no difference in the rate of distant recurrences between the two groups. These data continue to suggest that non-operative management does not compromise oncologic outcome, and that preservation of the rectum is achieved in a majority of patients, concluded the authors. ...
Gastrointestinal lymphomas represent 5–20% of extranodal lymphomas and mainly occur in the stomach and small intestine. Clinical findings are not specific, thus often determining a delay in the diagnosis. Imaging features at conventional and cross-sectional imaging must be known by the radiologist since he/she plays a pivotal role in the diagnosis and disease assessment, thus assisting in the choice of the optimal treatment to patients. This review focuses on the wide variety of imaging presentation of esophageal, gastric, and small and large bowel lymphoma presenting their main imaging appearances at conventional and cross-sectional imaging, mainly focusing on computed tomography and magnetic resonance, helping in the choice of the best imaging technique for the disease characterization and assessment and the recognition of potential complications.
Corneal confocal microscopy detects small fibre neuropathy in patients with upper gastrointestinal cancer and nerve regeneration in chemotherapy induced peripheral neuropathy Academic Article ...
New life-saving treatments for Carcinoid tumors | gastrointestinal neoplasms | neuroendocrine tumors in clinical trial on Study of Lanreotide in Patients With Metastatic Gastrointestinal Neuroendocrine Tumors Who Are Undergoing Liver-directed Radioembolization With Yttrium-90 Microspheres
Many gastrointestinal neuroendocrine tumours (GI NETs) are staged differently than other types of GI cancer. These include NETs of the: stomach small intestine and ampulla of Vater colon and rectum (also called the large intestine)appendix (not part of the GI tract, but often grouped with GI organs)
Many risk factors may increase your chance of developing gastrointestinal carcinoid tumors. This guide will help you learn about possible causes of gastrointestinal carcinoid tumors.
TY - JOUR. T1 - Chromogranin a in diagnosing and monitoring patients with gastroenteropancreatic neuroendocrine neoplasms. T2 - A large series from a single institution. AU - Massironi, Sara. AU - Rossi, Roberta Elisa. AU - Casazza, Giovanni. AU - Conte, Dario. AU - Ciafardini, Clorinda. AU - Galeazzi, Marianna. AU - Peracchi, Maddalena. PY - 2014/2/6. Y1 - 2014/2/6. N2 - Background/Aims: Plasma chromogranin A (CgA) is the most widely used biochemical biomarker in the diagnostic workup and follow-up of gastroenteropancreatic neuroendo- crine neoplasms (GEP-NENs). Herein, we assessed the clinical utility of CgA in diagnosing and monitoring a large series of GEP-NENs. Patients and Methods: A total of 181 GEP-NEN patients (87 males, 94 females) with pancreatic (n = 81) and gastrointestinal neoplasms (n = 100) were included; 99 patients had grade (G)1 NENs (Ki-67 ≤2%), 57 G2 NENs (Ki-67 3-20%) and 25 G3 NENs (Ki-67 ,20%); 81 patients had tumor-node-metastasis (TNM) stage I, 14 stage II, 17 stage ...
Gastrointestinal carcinoid tumors | Carcinoid complete resection. Surgery: Treatment in Tuebingen, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Gastrointestinal carcinoid tumors. Gastroenterology: Diagnostic in Hamburg, Germany ✈. Prices on BookingHealth.com - booking treatment online!
Synchronous Gastrointestinal Carcinoid Tumor and Colon Adenocarcinoma: Case Reports and Literature Review - Order reprints #903580
For gastrointestinal carcinoid tumors that have not spread to distant sites, surgery is usually the primary or first treatment. Learn about other treatment options here.
Gastrointestinal carcinoid, also called carcinoid tumor, is the most common primary tumor of the small bowel and appendix. Gastrointestinal carcinoid accounts for more than 95% of all carcinoids.
New Data Shows Positive Chromogranin-A Biomarker Results in GI-NET Patient. Phase I/II Clinical Trial with TKM-PLK1 Ongoing in Patients with Advanced Gastrointestinal Neuroendocrine Tumors (GI-NET) or Adrenocortical Carcinoma (ACC). VANCOUVER, British Columbia, Oct. 4, 2013 (GLOBE NEWSWIRE) -- Tekmira Pharmaceuticals Corporation (Nasdaq:TKMR) (TSX:TKM), a leading developer of RNA interference (RNAi) therapeutics, today announced that it presented additional TKM-PLK1 data at the 6th Annual NET Conference hosted by the North American Neuroendocrine Tumor Society (NA-NETS) to be held in Charleston, South Carolina from October 4-5, 2013.. We are pleased to present data at this conference reaching researchers and physicians treating patients who have been diagnosed with neuroendocrine tumors. We have an ongoing Phase I/II clinical trial with TKM-PLK1, with current enrollment targeting patients with either advanced Gastrointestinal Neuroendocrine Tumors (GI-NET) or Adrenocortical Carcinoma (ACC), ...
TY - JOUR. T1 - A case of malignant gastrointestinal stromal tumor of the uncommitted type. AU - Hayama, Satoshi. AU - Yabiku, Takashi. AU - Takenouchi, Nobuo. AU - Kato, Hiroyuki. AU - Nishihara, Hiroshi. PY - 2001/1/1. Y1 - 2001/1/1. N2 - We report a case of gastrointestinal stromal tumor (GIST) with peritoneal dissemination. A 73-year-old man was diagnosed to have a lesion of the stomach by an upper gastrointestinal barium study at an annual physical examination. Subsequently, melena was recognized and the patient was referred to our hospital. Gastrointestinal endoscopy revealed a huge submucosal tumor extending from the gastric body to the fundus which was ulcerated and hemorrhagic. Under the suspected diagnosis of the huge submucosal tumor of malignancy, total gastrectomy, splenectomy, pancreatectomy, and D2 dissection were performed. During the operation, another mass was found on the serosa of the sigmoid colon and resected. Histological examination revealed that the tumor was a GIST of ...
Contexte : Les tumeurs neuroendocrines (TNE) sont hétérogènes, et les tableaux et options thérapeutiques sont variables. À notre connaissance, il nexiste pas détudes randomisées et il y a peu détudes à long terme sur les résultats chez les patients. Le rôle du traitement chirurgical et médicamenteux de la maladie locale, régionale et métastatique continue dêtre évalué dans la littérature.. Méthodes : Nous avons procédé à une interrogation démographique du Registre provincial du cancer pour recenser les patients atteints de TNE gastro-intestinales provenant de lestomac, de lintestin grêle, du côlon et du rectum, diagnostiqués entre 1990 et 2005 et nous avons évalué les résultats.. Résultats : Nous avons examiné les données clinico-pathologiques des résultats enregistrés chez 530 patients atteints de TNE gastro-intestinales. Lincidence globale des TNE a augmenté de 11 par million à 19 par million pendant la période de létude. Le stade de la maladie et ...
Pancreatic neuroendocrine tumors (pNETs) comprise with gastrointestinal carcinoids, the primary sets of gastrointestinal neuroendocrine tumors (GI-NETs). menin (Desk-3). Menin interacts with several proteins/transcription elements, which are essential in regulating cell development, cell cycle development and several additional cellular procedures (Desk-3) [46]. Lately, furthermore to these traditional endocrine tumors, an elevated event of tumors in additional places are reported in Males1 individuals, including carcinoids (gastric, thymic, lung) [46,47]; CNS tumors (meningiomas, ependymomas) [46,48]; easy muscle mass tumors (leiomyomas and leiomyosarcomas) [46,49], and pores and skin tumors (angiofibromas, collagenomas, lipomas, melanomas) [46,50]. With regards to pNETs virtually all individuals with Males1 possess NF-PETs, yet, in most individuals they may be microscopic and therefore cause medical symptoms in mere 0C13% in various series (Desk-2) [46]. On the other hand, practical pNETs buy ...
This phase II trial is studying how well sorafenib works in treating patients with malignant gastrointestinal stromal tumor that progressed during or af
View Notes - Gallbladder Cancer - TAddona from STEP 1 at Montgomery College. Gallbladder Cancer Epidemiology • Incidence ~ 5000 • 5 th most common GI malignancy • Women > men • High
New Hope Unlimited offers personalized, non-invasive Alternative Cancer Treatments for Gastrointestinal Carcinoid Cancer. Call 480-666-1403 today.
TY - JOUR. T1 - Upper gastrointestinal cancer pathology reporting: a regional audit to compare standards with minimum datasets. AU - King, PM. AU - Blazeby, JM. AU - Gupta, J. AU - Alderson, D. AU - Moorghen, M. PY - 2004/7. Y1 - 2004/7. N2 - Aims: Accurate pathological (pTNM) staging of oesophageal and gastric cancer provides important prognostic information. The aim of this study was to compare the standard of pathology reporting of oesophageal and gastric cancer resections from a cancer network with standards set by the Royal College of Pathologists. Methods: All reports for oesophageal and gastric cancer resections from the five hospitals in the cancer network in 2001 were collected. Individual items of information were compared with minimum datasets provided by the Royal College of Pathologists. Items were classified as complete, partially complete, or absent. Results: One hundred and ten reports were audited (54 oesophageal and 56 gastric). Fourteen gastric and 17 oesophagectomy ...
At the 25th UEG Week in Barcelona, researchers presented that long-term aspirin use significantly reduced the incidence of digestive cancers. The study c
Background: Colorectal cancer (CRC) is the most prevalent gastrointestinal (GI) cancer. With 5% risk of developing CRC in life, it became the third leading cause of cancer death in developed nations. In Nigeria, it is the most common GI cancer. However, there are limited data on CRC in the study area (North-Western part of Nigeria). The aim of this study was to identify the clinical, endoscopic and histological profile of CRC seen on colonoscopy. Methodology: This was a retrospective descriptive study where colonoscopic and histological records of suspected CRC in the study centre between January 2008 to December 2017 were evaluated. Results: Records of 135 patients were reviewed, and males constituted 63.7%. The mean age was 46.61 ± 16.80 years, with 30-39 years as a modal group. Common presentations were diarrhoea (86.7%) and bleeding per rectum (68.9%). Areas affected were rectosigmoid colon (63%), ascending colon (14.1%), descending colon (8.9%), transverse colon (7.4%) and anal canal ...
Get complete guidance on obesity, diabetes treatment, colon & GI problems from Digestive Surgery Clinic. Dr. Sarfaraz Baig will help you to be fit & health.
Dr. Pavel Conovalciuc answered: Many: Oral cancer/pharyngeal/esophageal/stomach/pancreatic/liver/colon/rectal/endocrine cancers (usu...
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are unusual and relatively rare neoplasms. They characteristically synthetize, store and secrete a variety of peptides and neuroamines, which can lead to development of disctinct clinical syndromes. Clinical symptoms and presentations vary depending on the location and hormones produced by the tumor. The diagnosis of NETs is established by histological examination and the immunohistochemical detection of general neuroendocrine markers, such as chromogranin A (CgA) and synaptophysin. An update of the WHO classifi cation has resulted in a new classification dividing neuroendocrine neoplasms into neuroendocrine tumors (NETs) including G1 (Ki67 index ≤2%) and G2 (Ki67 index 3-20%) tumors and neuroendocrine carcinomas (NECs) with Ki67 index ,20%, G3. The different available therapeutic approaches, including surgery, liver-directed ablative therapies, peptide receptor radionuclide therapy, and systemic hormonal, cytotoxic or targeted therapy, ...
Gambogic acid has a marked anti-tumor effect for gastric and colorectal cancers in vitro and in vivo. However, recent investigations on gambogic acid have focused mainly on mono-drug therapy, and its potential role in cancer therapy has not been comp
The aim was to investigate the serum levels of leptin, TNF-alpha, IL-1 beta, IL-6, insulin, and growth hormone in patients with upper gastrointestinal cancer and cachexia. A total of 39 patients with various advanced stage (stage IV) gastrointestinal malignancies were enrolled. These cancer patients were divided into two groups according to the presence or absence of cachexia. Fifteen healthy adults were recruited as the control group. Body mass index (BMI; kg/m2) was calculated. Serum leptin, tumour necrosis factor (TNF)-α interleukin (IL)-1 beta, interleukin (IL)-6, growth hormone, insulin, glucose, triglyceride, total protein, albumin, erythrocyte sedimentation rate, and CRP were measured. In both cancer groups (cachectic and non-cachectic) body mass index and serum leptin levels were lower than controls (p , 0.001). Serum IL-1 beta, IL-6, and growth hormone levels were higher in both cachectic and non-cachectic groups than those of controls (p , 0.05). Serum TNF-α level in non-cachectic ...
Welcome to the Pathology Education Informational Resource (PEIR) Digital Library, a multidisciplinary public access image database for use in medical education. ...
Introduction: Sоmatostatin is a regulatory peptide with a variety of actions in normal and tumor cells. In recent years there are a lot of observations suggesting that the gastrointestinal neuroendocrine tumors (GEP-NETs) expressed somatostatin receptors (SS-R).The expression could be valuable for the prognosis of patients with GEP-NETs due to the research evidence that well-differentiated tumors express SS-R in the great majority of the cases ...
An exacerbated genomic instability characterizes hereditary and sporadic gastrointestinal cancer of the microsatellite mutator phenotype (MMP), generating somatic frameshift mutations in genes containing mononucleotide repeats. We have recently shown that approximately 50, 40, and 30% of MMP + colon tumors harbor frameshift mutations in (G)8, (A)8, and (C)8 tracks within the proapoptotic gene BAX and the hMSH3 and hMSH6 DNA mismatch repair genes, respectively. Here we report a higher incidence of frameshift mutations in these 3 genes in a panel of 25 MMP+ gastric adenocarcinomas: 64% in BAX and hMSH3, and 52% in hMSH6. These results support a multiple mutator gene model for the stepwise unfolding of the MMP and further illustrate the importance of the escape from apoptosis in gastrointestinal cancer. The tumor suppressor role played by BAX is also supported by the finding of other somatic BAX mutations, including recurrent missense mutations, not only in gastrointestinal cancer of the MMP but ...
Dr. Chin is committed to ensuring the delivery of care of the highest quality and value. He provides clinical expertise in diagnosing and treating the full range of cancers, including those of the lung, breast, and central nervous system. In addition, he serves on national leadership teams formed to advance the practice of cancer care. Dr. Chin is currently a member of the Payment Reform Task Force for the American Society of Clinical Oncology and has previously served on their Clinical Practice Committee and as a health policy fellow. He was one of just two oncologists in the US selected to participate in a year-long program on policy leadership ...
Brain metastasis (BM) frequently occurs in patients with cutaneous melanoma, lung, and breast cancer; although, BM rarely arises from cancers of the gastrointestinal tract (GIT). The reported incidence of GIT cancer BM is less than 4%. In the last few years, effective systemic therapy has prolonged the survival of GIT patients and consequently, the incidence of developing BM is rising. Therefore, the epidemiology and biology of BM arising from GIT cancer requires a more comprehensive understanding. In spite of the development of new therapeutic agents for patients with metastatic GIT cancers, survival for patients with BM still remains poor, with a median survival after diagnosis of less than 4 months. Limited evidence suggests that early detection of isolated intra-cranial lesions will enable surgical resection plus systemic and/or radiation therapy, which may lead to an increase in overall survival. Novel diagnostic methods such as blood-based biomarker biopsies may play a crucial role in the early
Our goal was to assess the metastatic potential of CRC in order to develop clinically effective individualised treatment based on that potential against stage I of CRC (pT1N0M0). Using cDNA array, we first identified that of the many possible candidates, matrilysin was a major biomarker involved in nodal metastasis. We reported previously that matrilysin expression was confined to cancer cells, which not only correlated with tumour metastatic potential in a mouse model but was also implicated in the poor prognosis of gastrointestinal cancer patients. Moreover, matrilysin is an established target of the Wnt signal pathway. For these reasons, we specifically focused on matrilysin for further analysis.. MMPs have long been a potential target for cancer therapy. However, clinical trials of synthetic metalloproteinase inhibitors have been disappointing.26 One major reason for this lack of success may result from the apparent uncertainty regarding the precise spectrum of inhibitory activity required. ...
This study aimed to investigate the efficacy and safety of cytokine-induced killer (CIK)/dendritic cell combined with CIK (DC-CIK) cell therapy in advanced gastrointestinal cancer (GIC). The PubMed, Cochrane library, and Embase were searched to conduct a meta-analysis of clinical controlled trials to evaluate the efficacy and safety of CIK/DC-CIK cell therapy in advanced GIC. The pooled risk ratios (RRs) or weighted mean difference (WMD) with 95% confidence intervals (95% CIs) were calculated. A total of nine studies with 1113 patients were identified. The overall survival (RR = 1.84, 95% CI = 1.41-2.40, Pheterogeneity = 0.654, I2 = 0%), progression-free survival (RR = 1.99, 95% CI = 1.52-2.60, Pheterogeneity = 0.727, I2 = 0%), and quality of life (WMD = 16.09, 95% CI = 1.66-30.52, Pheterogeneity | 0.001, I2 = 98.8%) were significantly improved in patients who received chemotherapy combined with CIK/DC-CIK cells, and no severe adverse events were reported. This meta-analysis suggested that the
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Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of digestion, including the esophagus, stomach, biliary system, pancreas, small intestine, large intestine, rectum and anus. The symptoms relate to the organ affected and can include obstruction (leading to difficulty swallowing or defecating), abnormal bleeding or other associated problems. The diagnosis often requires endoscopy, followed by biopsy of suspicious tissue. The treatment depends on the location of the tumor, as well as the type of cancer cell and whether it has invaded other tissues or spread elsewhere. These factors also determine the prognosis. Overall, the GI tract and the accessory organs of digestion (pancreas, liver, gall bladder) are responsible for more cancers and more deaths from cancer than any other system in the body. There is significant geographic variation in the rates of different gastrointestinal cancers. Esophageal cancer is the sixth-most-common ...
Common cancers Bladder Cancer Breast Cancer Colorectal Cancer Head and Neck Cancer Kidney Cancer Lung Cancer Lymphoma Melanoma Pancreatic Cancer Prostate Cancer Thyroid Cancer Uterine Cancer AAcute Lymphoblastic Leukemia (ALL)Acute Myeloid Leukemia (AML)AdenocarcinomaAdrenocortical CarcinomaAIDS-Related LymphomaAnal CancerAppendix Cancer - see Gastrointestinal Carcinoid Tumors BBasal Cell Carcinoma - see Skin Cancer (Nonmelanoma)Bile Duct Cancer, ExtrahepaticBladder CancerBone Cancer […]. ...
Koch P, del Valle F, Berdel WE, Willich NA, Reers B, Hiddemann W, Grothaus-Pinke B, Reinartz G, Brockmann J, Temmesfeld A, Schmitz R, Rübe C, Probst A, Jaenke G, Bodenstein H, Junker A, Pott C, Schultze J, Heinecke A, Parwaresch R, Tiemann M, German Multicenter Study Group: Primary gastrointestinal non-Hodgkins lymphoma: I. Anatomic and histologic distribution, clinical features, and survival data of 371 patients registered in the German Multicenter Study GIT NHL 01/92. J Clin Oncol; 2001 Sep 15;19(18):3861-73 ...
Colonic malignancy is a clinically significant complication of Crohn disease in patients with pancolitis beginning in childhood. Although the risk of malignancy in Crohn disease is not as high as that... more
ESMO is a Swiss-registered not-for-profit organisation. All funding for this site is provided directly by ESMO or via grants from the sponsors and supporters.. Via L. Taddei 4, 6962 Viganello - Lugano - CH © Copyright 2017 European Society for Medical Oncology All rights reserved worldwide.. ...
Various strategies and modalities of treatment are employed in the management of GI lymphomas based on the area of involvement, histological type and clinical staging.12 39 40 For example, early-stage follicular lymphoma follows an indolent course and may be followed clinically with a watch and wait policy.41 Indeed, a retrospective study by Young and colleagues noted a similar overall 7.5-year survival rate among those with follicular lymphoma that underwent watchful waiting or aggressive combined modality treatment.42. More than 70% of patients with early-stage (Ann Arbor Classification Stages I-III) MALT lymphomas associated with H. pylori infection can achieve remission with triple or quadruple eradication therapy alone,4 43 44 with a tumour location, patient ethnicity, depth of invasion and molecular feature all influencing response rates.24 Radiation therapy and chemotherapy are reserved for advanced tumours and non-responders. Surgery should prove necessary only in instances of ...
Gastrointestinal carcinoid tumor treatment often includes resection of the primary tumor and local lymph nodes. Other treatment options include somatostatin analogs, interferons, treatment of hepatic masses, radionuclides, and symptomatic therapy. Get detailed information in this clinician summary.
Introduction. This short presentation will describe approaches to these diseases, standard treatment protocols and advances in radiation and chemotherapy-based treatments. Particular emphasis will be placed upon the special considerations in cats with regards drug metabolism, nutritional support during therapy and prognosis of individual diseases.. Feline Lymphoma. Diagnosis and Staging. The various anatomical forms of feline lymphoma (mediastinal, alimentary, renal, multicentric and extranodal) have been well described. Alimentary--characterised by gastric, intestinal, or mesenteric lymph node involvement, this is one of the more common forms of feline lymphoma. Gastrointestinal lymphoma may present as a solitary mass lesion or as a diffuse infiltration of extensive areas of bowel. Clinical signs are non-specific, including anorexia, vomiting, and diarrhoea. Animals previously diagnosed with lymphoplasmacytic gastroenteritis have been reported subsequently to develop gastrointestinal lymphoma. ...
This guide is designed for all clinicians who look after people who have been treated for upper gastrointestinal (GI) cancer. It is also designed for patients who are experiencing upper GI symptoms following any cancer treatment. Some of these will be doctors, others may be senior nurses and increasingly, other allied health professionals.. Some lower GI symptoms are also included because these are common after treatment for upper GI cancers. However, for more detailed advice about managing lower GI symptoms please refer to Guidance: The practical management of the gastrointestinal symptoms of pelvic radiation disease.1. The GI consequences of chemotherapy, radiotherapy and resectional surgery are not that different. Historically, clinicians have associated specific clusters of symptoms with typical diagnoses especially in patients who have been treated for upper GI and hepatopancreatobiliary cancer. Research increasingly suggests that specific symptoms are not reliable indicators of the ...
According to the latest report published by Credence Research, Inc. Gastrointestinal Stents Market - Growth, Future Prospects and Competitive Analysis, 2017-2025, the global gastrointestinal stents market was valued at US$ 348.9 Mn in 2016, and is expected to reach US$ 510.0 Mn by 2025, expanding at a CAGR of 4.2% from 2017 to 2025.. Browse the full report Gastrointestinal Stents Market - Growth, Future Prospects and Competitive Analysis, 2017-2025 at http://www.credenceresearch.com/report/gastrointestinal-stents-market. Market Insights Gastrointestinal diseases are highly prevalent in high risk geriatric population. Drastic change in lifestyle and dietary habits has resulted in rise in prevalence of chronic diseases, obesity, high blood pressure, and also has resulted in escalated morbidity and mortality from conditions such as GI cancers, bowel diseases, and others. Gastrointestinal stents are used for correcting obstructions in the GI tract and in cases of strictures, tumors, and ...
The Breast SPORE Developmental Research Program provides pilot funding to promote excellent translational research in breast cancer. These funds allow early, high-risk research to move solid basic science findings toward clinical application, as well as the migration of provocative clinical observations back to the laboratory in order to understand their mechanistic basis. Main criteria for selection and funding of developmental (pilot) projects include scientific merit, relevance to mammary biology and/or breast cancer, collaboration and potential for extramural peer-reviewed funding. There also is an emphasis on utilization of emerging technologies and on young investigators.. The GI SPORE Developmental Research Program solicits applications twice yearly from investigators at Vanderbilt and Meharry Medical College. Proposals are reviewed for scientific merit and the likelihood of leading to extramural funding. Special emphasis is placed on attracting young investigators into GI cancer ...
A new study presented at the 2015 European Cancer Congress in Vienna, Austria suggests that aspirin may double the chances of survival for people with gastrointestinal (GI) cancers.
The European School of Oncology was founded by Umberto Veronesi and Laudomia Del Drago in 1982, with the aim of contributing to the reduction of deaths from cancer due to late diagnosis and/or inadequate treatment
The small intestine or small bowel is an organ in the gastrointestinal tract where most of the end absorption of nutrients and ... See also: Gastrointestinal disease. The small intestine is a complex organ, and as such, there are a very large number of ... "The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling ... Neoplasms (cancers) *Adenocarcinoma. *Carcinoid. *Gastrointestinal stromal tumor (GIST). *Lymphoma. *Sarcoma. *Leiomyoma. * ...
... or gastrointestinal duplications) due to outflow obstructions or narrowings, or abnormal connections, may also present as a ... ICD-10 classifies neoplasms into four main groups: benign neoplasms, in situ neoplasms, malignant neoplasms, and neoplasms of ... The term 'neoplasm' is a synonym of "tumor". 'Neoplasia' denotes the process of the formation of neoplasms/tumors, the process ... "II Neoplasms". World Health Organization. Retrieved 19 June 2014.. *^ a b Abrams, Gerald. "Neoplasia I". Retrieved 23 January ...
Application of endoscopic resection (ER) to gastrointestinal (GI) neoplasms is limited to lesions with no risk of nodal ... The resected size and shape can be controlled, en bloc resection is possible even in a large neoplasm, and neoplasms with ... Kakushima, Naomi; Fujishiro, Mitsuhiro (2008). "Endoscopic submucosal dissection for gastrointestinal neoplasms". World Journal ... So this technique can be applied to the resection of complex neoplasms such as large neoplasms, ulcerative non-lifting ...
... recent gastrointestinal, obstetric, or gynecologic surgery; malignant neoplasms intestinal obstruction; decubitus ulcers; ... colonize the lower gastrointestinal tract, they can contaminate compound lower extremities fractures. Septic arthritis due to ... is often associated with a gastrointestinal source, pigmented Prevotella and Porphyromonas spp. and Fusobacterium spp.with ... Perforated appendicitis, diverticulitis, inflammatory bowel disease with perforation and gastrointestinal surgery are often ...
"The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia". Blood. 127 (20): ... "Mast cells in gastrointestinal disease". Gastroenterology Hepatology (N Y). 6 (12): 772-7. PMC 3033552 . PMID 21301631 ... "Gastrointestinal manifestations of systemic mastocytosis". World Journal of Gastroenterology. 14 (45): 7005-8. doi:10.3748/wjg ...
esophageal neoplasm (en) , esophageal disease (en) gastrointestinal system cancer (en) Espezialitatea. onkologia. ... Han Y, Chen W, Li P, Ye J (2015). «Association Between Coeliac Disease and Risk of Any Malignancy and Gastrointestinal ...
G1 and G2 neuroendocrine neoplasms are called neuroendocrine tumors (NETs) - formerly called carcinoid tumours. G3 neoplasms ... Gastrointestinal Carcinoid Tumors Treatment cancer.gov Archived 2011-06-27 at the Wayback Machine National Cancer Institute. ... Although there are many kinds of NETs, they are treated as a group of tissue because the cells of these neoplasms share common ... NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, ...
... has been shown particularly effective against sarcomas, lymphomas, and gastrointestinal neoplasms.[citation needed ...
"Clinicopathological relevance of the association between gastrointestinal and sebaceous neoplasms: the Muir-Torre syndrome". ... Bernstein C, Bernstein H (2015). "Epigenetic reduction of DNA repair in progression to gastrointestinal cancer". World J ...
Along with neoplasms of the sebaceous gland, this patient developed cerebral neoplasms, characteristic of Turcot syndrome. ... Gastrointestinal and genitourinary cancers are the most common internal malignancies. Colorectal cancer is the most common ... Age of onset of first sebaceous neoplasm: 2 = 2 points. Personal history of Lynch related cancers: No = 0 points, Yes = 1 point ... 2014). "A clinical scoring system to identify patients with sebaceous neoplasms at risk for the Muir-Torre variant of Lynch ...
Known or suspected intracranial neoplasm or mass lesion. *Known hypersensitivity to drotrecogin or any component ... Recent (within 6 weeks) gastrointestinal bleeding. *Recent administration (within 3 days) of thrombolytic therapy ...
... ulcerative colitis and neoplasms (cancer). Also, feces may be analyzed for any fecal occult blood, which is indicative of a ... combines with gastrointestinal bleeding from any source (black stool). It can also suggest a carcinoma of the ampulla of Vater ... which will result in gastrointestinal bleeding and biliary obstruction, resulting in silver stool. Feces can be green due to ... gastrointestinal bleeding. A quick test for fecal contamination of water sources or soil is a check for the presence of E. coli ...
The most common type is a sarcoma followed by lymphoma, extragonadal germ cell tumor, and Gastrointestinal stromal tumor/GIST. ... Retroperitoneal fibrosis Retroperitoneal lymph node dissection It is also possible to have a neoplasm in this area, more ... commonly a metastasis; or very rarely a primary neoplasm. ...
The body can absorb up to 6 mg iron daily from the gastrointestinal tract. In many cases the patient has a deficit of over ... Causes of decreased production include iron deficiency, vitamin B12 deficiency, thalassemia, and a number of neoplasms of the ... In older men and women, the chances are higher that bleeding from the gastrointestinal tract could be due to colon polyps or ... Certain gastrointestinal disorders can cause anemia. The mechanisms involved are multifactorial and not limited to ...
Neoplasms benign, malignant and unspecified (including cysts and polyps); Nervous system disorders; Pregnancy, puerperium, and ... Gastrointestinal disorders; General disorders and administration site conditions; Hepatobiliary disorders; Immune system ...
The majority of deaths were caused by neoplasms, mainly mammary tumors. The Siamese also has a higher rate of morbidity. They ... are at higher risk of neoplastic and gastrointestinal problems, but have a lower risk of feline lower urinary tract disease. ...
Neoplasms occurring in epithelial tissue such as the liver, gastrointestinal tract, and the pancreas have been linked to ...
When seen on upper gastrointestinal series, a pancreatic rest may appear to be a submucosal mass or gastric neoplasm. Most are ... A hamartoma is a mostly benign, local malformation of cells that resembles a neoplasm of local tissue but is usually due to an ... Case report: ectopic pancreatic rest in the proximal stomach mimicking gastric neoplasms. Clin Radiol. 2007 Jun;62(6):600-2. ... the definition of hamartoma versus benign neoplasm is often unclear, since both lesions can be clonal. Lesions such as adenomas ...
... , M.D. (born 1950) is Professor of Surgery, Chief, Division of Gastrointestinal and Laparoscopic Surgery and Co- ... Ellis, C. T.; Barbour, J. R.; Shary, T. M.; Adams, D. B. (2010). "Pancreatic cyst: Pseudocyst or neoplasm? Pitfalls in ... Theruvath, T. P.; Morgan, K. A.; Adams, D. B. (2010). "Mucinous cystic neoplasms of the pancreas: How much preoperative ... Association American College of Surgeons American Society for Gastrointestinal Endoscopy Society of American Gastrointestinal ...
腫瘤:內分泌腺腫瘤(C73-C75/D34-D35、193-194/226-227(英語:List of ICD-9 codes 140-239: neoplasms#Malignant neoplasm of other and unspecified ... World Journal of Gastrointestinal Oncology. 2014-10-15, 6 (10): 381-92. PMC 4197429. PMID 25320654. doi:10.4251/wjgo.v6.i10.381 ... 最後一種則是主要發生在女性的胰黏液性囊狀腫瘤(英語:pancreatic mucinous cystic neoplasm)(MCNs),它可能維持良性或發展為惡性[61]。如果腫瘤變大、造
... blood vessel constriction in the skin and gastrointestinal tract, smooth muscle (bronchiole and capillary) dilation, and ... Neoplasms include: *Pheochromocytoma (most common), a catecholamine-secreting tumor of the adrenal medulla[1][5] ...
The large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and of the digestive system ... and left-sided colorectal neoplasms after colonoscopy: population-based study". J Natl Cancer Inst. 102 (2): 89-95. doi:10.1093 ... The descending colon is also called the distal gut, as it is further along the gastrointestinal tract than the proximal gut. ... Johansson, Malin E.V.; Sjövall, Henrik; Hansson, Gunnar C. (2013-06-01). "The gastrointestinal mucus system in health and ...
J. A. Dominitz, et al., American Society for Gastrointestinal Endoscopy, "Complications of Colonsocopy"[permanent dead link], ... and left-sided colorectal neoplasms after colonoscopy: population-based study". J Natl Cancer Inst. 102 (2): 89-95. doi:10.1093 ... American Society for Gastrointestinal Endoscopy information. *colonoscopy app. Colonoscopy app is now available for android ... Sivak Jr., Michael V. (December 2004). "Polypectomy: Looking Back". Gastrointestinal Endoscopy. 60 (6): 977-982. doi:10.1016/ ...
"World Journal of Gastrointestinal Oncology. 6 (10): 381-92. doi:10.4251/wjgo.v6.i10.381. PMC 4197429. PMID 25320654.. ... "Islet Cell Tumors of the Pancreas / Endocrine Neoplasms of the Pancreas". The Sol Goldman Pancreas Cancer Research Center. ... "Journal of Gastrointestinal Oncology. 5 (6): 481-8. doi:10.3978/j.issn.2078-6891.2014.055. PMC 4226830. PMID 25436129.. ... Pancreatic mucinous cystic neoplasms are a broad group of pancreas tumors that have varying malignant potential. They are being ...
Gastrointestinal stromal tumors consist of a cluster of mesenchymal neoplasms that are formed from precursors to cells that ... Gastrointestinal stromal tumors (GIST) are mesenchymal tumors that affect the gastrointestinal tract. Treatment options have ... Gastrointestinal stromal tumors (GIST) are known to withstand cancer chemotherapy treatment and do not respond to any kind of ... Therapy with imatinib can inhibit the non-normal cell signaling mechanisms in gastrointestinal stromal tumors. This results in ...
Carney triad (CT) is characterized by the coexistence of three types of neoplasms, mainly in young women, including gastric ... A third condition, the Carney-Stratakis syndrome (CSS), describes the dyad of hereditary gastrointestinal stromal tumor (GIST) ... The Carney complex is a distinct entity, characterized by myxomatous neoplasms (cardiac, endocrine, cutaneous and neural), and ... Subsequent advances in molecular biology have led to the current terminology of gastrointestinal stromal tumors (GISTs). ...
... of all childhood renal neoplasms. This neoplasm is generally non-aggressive and amenable to surgical removal. However, a ... 2 with gastrointestinal anomalies, 1 with hydrocephalus, and 1 with the Beckwith-Wiedemann syndrome. The vast majority of ... It shows a mixture of the classic and cellular types in different areas of the neoplasm. A study conducted in 1998 found that ... Congenital mesoblastic nephroma, while rare, is the most common kidney neoplasm diagnosed in the first three months of life and ...
... gastrointestinal stromal tumors (GIST), Watson syndrome, astrocytic neoplasms, phaeochromocytomas and breast cancer. No ... which develops myeloproliferative neoplasms similar to those found in NF1 juvenile myelomonocytic leukemia/JMML) were used to ... an oral selective MEK inhibitor used previously in several advanced adult neoplasms. The children enrolled in the study ...
... of the most common mesenchymal neoplasm of the gastrointestinal tract (GI tract), viz., Gastrointestinal stromal tumors or ( ... myeloproliferative neoplasm/myeloblastic leukemia; a T-lymphoblastic leukemia/lymphoma; or myeloid sarcoma; b) are diagnosed ... are associated with an array of clinically significant neoplasms. This gene encodes a typical receptor tyrosine kinase, which ... a form of myeloproliferative neoplasm/myeloblastic leukemia associated with little or no eosinophilia; c) T-lymphoblastic ...
For example, neoplasms characterized by high-grade features, invasive glands and or signet ring cells, are termed ... Harmon R, Sugarbaker P (2005). "Prognostic indicators in peritoneal carcinomatosis from gastrointestinal cancer". Int Semin ... Young R (2004). "Pseudomyxoma peritonei and selected other aspects of the spread of appendiceal neoplasms". Semin Diagn Pathol ... ISBN 978-0-323-35909-2. Sugarbaker P (2006). "New standard of care for appendiceal epithelial neoplasms and pseudomyxoma ...
Urinary and gastrointestinal elimination remain important to the process of reducing the bilirubin load. The biliblanket setup ... Hematological changes Paralytic ileus Neoplasms Skin lesions Café au lait spots Allergic diseases (allergic asthma, rhinitis, ...
Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast ... Mucinous cystadenoma is an obsolete term for appendiceal mucinous neoplasm. Small carcinoids (. ...
Carrington syndrome Cartilage-hair hypoplasia Cartilage hair hypoplasia like syndrome Cartilaginous neoplasms Cartwright-Nelson ... Congenital erythropoietic porphyria Congenital facial diplegia Congenital fiber type disproportion Congenital gastrointestinal ... hypoxia Cerebral malformations hypertrichosis claw hands Cerebral palsy Cerebral thrombosis Cerebral ventricle neoplasms ... Choriocarcinoma Chorioretinitis Chorioretinopathy dominant form microcephaly Choroid plexus cyst Choroid plexus neoplasms ...
... neoplasm protein - Nernst equation - nerve - nerve growth factor - nerve growth factor receptor - nerve tissue protein - nerve ... gastrointestinal hormone receptor - gastrula - Gel electrophoresis - gene - gene expression - gene pool - gene regulatory ...
Gastrointestinal track lesions often occur as multiple lymphoid polyps in the large intestine. At diagnosis, more than 50% of ... This lymphoma also belongs to a group of lymphoid neoplasms with plasmablastic differentiation that involve malignant ... The extracavitary tumors may develop in lymph nodes, bone, bone marrow, the gastrointestinal tract, skin, spleen, liver, lungs ... Individuals with extracavitary PEL present with lesions in the lung, central nervous system, gastrointestinal tract, and/or ...
Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone ... gastrointestinal tract, bone, sinuses, ears, and/or testes. The disease may also present as a pDC leukemia, i.e. increased ... Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... Blastic plasmacytoid dendritic cell neoplasm has a high rate of recurrence following initial treatments with various ...
They form a subset of neoplasms. A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often ... Rates of gastrointestinal cancers are increased in people with Crohn's disease and ulcerative colitis, due to chronic ... In the general population, NSAIDs reduce the risk of colorectal cancer; however, due to cardiovascular and gastrointestinal ... World Journal of Gastrointestinal Oncology. 5 (3): 43-49. doi:10.4251/wjgo.v5.i3.43. PMC 3648662. PMID 23671730. Narayanan L, ...
Gastrointestinal (GI) involvement can rarely occur with chronic lymphocytic leukemia. Some of the reported manifestations ... Hairy cell leukemia is also a neoplasm of B lymphocytes, but the neoplastic cells have a distinct morphology under the ... ISBN 978-0-7817-5007-3. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ... Choi SM, O'Malley DP (December 2018). "Diagnostically relevant updates to the 2017 WHO classification of lymphoid neoplasms". ...
... diarrhoea and gastrointestinal disturbances. Once successful periodontal treatment has been completed, with or without surgery ... neoplasms, endocrine, nutritional and metabolic, and traumatic lesions or gingival pigmentation. Periodontitis Necrotizing ...
Due to its 5-HT2A receptor antagonism, phenoxybenzamine is useful in the treatment of carcinoid tumor, a neoplasm that secretes ... 206-. ISBN 978-0-08-054111-2. Timothy S. Gaginella; James J. Galligan (25 July 1995). Serotonin and Gastrointestinal Function. ...
Radiation enteropathy The gastrointestinal tract can be damaged following abdominal and pelvic radiotherapy. Atrophy, fibrosis ... Hypopituitarism commonly develops after radiation therapy for sellar and parasellar neoplasms, extrasellar brain tumours, head ...
H7 Shigella Salmonella Campylobacter jejuni Hemorrhoids Neoplasm - such as colorectal cancer Angiodysplasia Bleeding from a ... Lower gastrointestinal bleeding, commonly abbreviated LGIB, is any form of gastrointestinal bleeding in the lower ... LGIB accounts for 30-40% of all gastrointestinal bleeding and is less common than upper gastrointestinal bleeding (UGIB). It is ... A lower gastrointestinal bleed is defined as bleeding originating distal to the ileocecal valve which includes the colon, ...
Director of the Division of Gastrointestinal/Liver Pathology, and Director of the Department of Pathology. He is a world expert ... Pancreatic Neoplasms, November 2018". expertscape.com. November 2018. Retrieved 2018-11-26. http://halstedthedocumentary.org/. ...
... neoplasms, and cysts are skin lesions that develop from the epidermal layer of the skin. Aberrant basal cell carcinoma ... "Paraneoplastic dermatological manifestation of gastrointestinal malignancies". World J. Gastroenterol. 15 (35): 4372-79. doi: ... an overview with emphasis on the myeloid neoplasms". Chem. Biol. Interact. 184 (1-2): 16-20. doi:10.1016/j.cbi.2009.10.009. ... neoplasms invading or aberrantly present in the dermis. Acquired progressive lymphangioma (benign lymphangioendothelioma) Acral ...
Wang S, Wang X, Liu M, Bai O (April 2018). "Blastic plasmacytoid dendritic cell neoplasm: update on therapy especially novel ... gastrointestinal tract, bone, sinuses, ears, and/or testes. The disease may also present as a pDC leukemia, i.e. increased ... Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare type of myeloid cancer in which malignant pDCs infiltrate the ... pDCs that undergo malignant transformation cause a rare hematologic disorder, blastic plasmacytoid dendritic cell neoplasm. In ...
It can also cause sialadenitis (an inflammation of the salivary gland), gastrointestinal disturbances, allergic reactions and ... "Malignant and benign neoplasms of the thyroid in patients treated for hyperthyroidism: a report of the cooperative ...
While chondrosarcoma is the most common form of a secondary malignant bone neoplasm found in cases of Ollier disease, other ... like chondrosarcomas but also much more aggressive tumors such as acute lymphocytic leukemia and gastrointestinal and ovarian ... Early detection and consistent and repeated monitoring is important in order to prevent and treat any potential bone neoplasms ... Clinical and radiological evaluations are conducted in order to detect the presence of bone neoplasms or lesions typically ...
Neoplasm Metastasis Cancer Brain tumor Tse V (10 November 2009). "Brain Metastasis". Medscape. Retrieved 13 January 2010. " ... Gastrointestinal cancers, especially colorectal and pancreatic carcinoma, 3% Lymphoma, 1% Lung cancer and melanoma are most ... Percy AK, Elveback LR, Okazaki H, Kurland LT (January 1972). "Neoplasms of the central nervous system. Epidemiologic ... the national survey of intracranial neoplasms". Neurology. 35 (2): 219-26. doi:10.1212/WNL.35.2.219. PMID 3969210. Tabouret E, ...
CEBPA mutation Myeloid neoplasms with germline DDX41 mutation Myeloid neoplasms with germline RUNX1 mutation Myeloid neoplasms ... NOS Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract Hepatosplenic T-cell lymphoma Subcutaneous ... neoplasms with PDGFRA rearrangement Myeloid/lymphoid neoplasms with PDGFRB rearrangement Myeloid/lymphoid neoplasms with FGFR1 ... NOS Lymphoid neoplasms Precursor lymphoid neoplasms B-lymphoblastic leukaemia/lymphoma, NOS B-lymphoblastic leukaemia/lymphoma ...
... is a cancer which arises from the anus, the distal opening of the gastrointestinal tract. Symptoms may include ... Chemotherapy commonly used is similar to other squamous cell epithelial neoplasms, such as platinum analogues, anthracyclines ... and Colostomy Failure in US Gastrointestinal Intergroup RTOG 98-11 Phase 3 Trial. Int J Radiation Oncol Biol Phys, 2013, Vol. ... "Risk of anal cancer in a cohort with human papillomavirus-related gynecologic neoplasm". Obstetrics and Gynecology. 117 (3): ...
2012). Handbook of Gastrointestinal Cancer (2 ed.). Chicester: John Wiley and Sons Ltd. pp. 243-244. ISBN 978-0-470-65624-2. ... ISBN 0-7817-5007-5. Frequency of lymphoid neoplasms. (Source: Modified from WHO Blue Book on Tumour of Hematopoietic and ...
"TREATING GASTROINTESTINAL MALIGNANCY WITH PROTON THERAPY". IBA White Paper. September 2016. Tae Hyung Kim (2020). "Proton beam ... Two prominent examples are pediatric neoplasms (such as medulloblastoma) and prostate cancer. Irreversible long-term side ... Indeed, the largest study to date showed that IMRT compared with proton therapy was associated with less gastrointestinal ... gastrointestinal and bladder side effects. Proton therapy for ocular (eye) tumors is a special case since this treatment ...
Its expression is also increased in a wide range of other malignant neoplasms. Factor X (F10) is frequently expressed in normal ... Trinchera M, Aronica A, Dall'Olio F (February 2017). "Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal ... It is also overexpressed in some cell lines originating from various malignant neoplasms. Thus, it is highly expressed in ... "Selectin Ligands Sialyl-Lewis a and Sialyl-Lewis x in Gastrointestinal Cancers". Biology. 6 (1): 16. doi:10.3390/biology6010016 ...
... in the upper gastrointestinal tract, lungs, upper airways, and/or other organs and 6) consists of variable histology with ... An Indolent Neoplasm With Features Distinct From Diffuse Large B-Cell Lymphoma Associated With Chronic Inflammation". The ...
... most notably Imatinib-mesylate in gastrointestinal stromal tumors (GISTs). Tyrosine kinase (a subclass of protein kinases) is ... a distinctive aggressive neoplasm showing rhabdoid features. Clinicopathologic, immunohistochemical, and ultrastructural study ...
Neoplasms. Digestive System Diseases. Gastrointestinal Diseases. Gastrointestinal Neoplasms. Digestive System Neoplasms. ... Endoscopic Submucosal Dissection for Gastrointestinal Neoplasms. The recruitment status of this study is unknown. The ... ESD was carried out by using a single-channel upper gastrointestinal endoscope with a water-jet system (Q260J; Olympus Optical ... Endoscopic submucosal dissection (ESD) is a newly developed technique in the field of endoscopic treatment for GI neoplasms, ...
Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse. Naomi Ohnishi ... Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse ... Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse ... Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse ...
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... Thomas ... Thomas P. Plesec, "Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their ...
Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the ... The neoplasms are positive for platelet-derived growth factor α (PDGFα) mutations. In addition to PDGFRα mutations, wild- ... They are usually located in the upper gastrointestinal track. These tumors are typically defined by the expression of c-KIT ( ... The therapeutic approach to locally developed gastrointestinal stromal tumors is surgical resection, either with open or ...
Clinical Trial on Acupuncture Therapy in Patients With Gastrointestinal Neoplasms Laparoscopic Surgery ... Clinical Trial on Acupuncture Therapy in Patients With Gastrointestinal Neoplasms Laparoscopic Surgery Brief description of ... Clinical evaluation includes gastrointestinal tract recovery of function, pain relief, life quality improvement. Blood ...
"Gastrointestinal Neoplasms" by people in this website by year, and whether "Gastrointestinal Neoplasms" was a major or minor ... "Gastrointestinal Neoplasms" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH ( ... Below are the most recent publications written about "Gastrointestinal Neoplasms" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Gastrointestinal Neoplasms". ...
... arise from neuroendocrine cells distributed mainly in the mucosa and submucosa of the gastrointestinal tract. In 2010, the ... Endoscopic Biopsy in Gastrointestinal Neuroendocrine Neoplasms: A Retrospective Study. *Xiao Han, Yun Cheng Cui, +12 authors ... Gastrointestinal neuroendocrine neoplasms (GI-NENs) arise from neuroendocrine cells distributed mainly in the mucosa and ... Histopathology of gastrointestinal neuroendocrine neoplasms. @inproceedings{Hirabayashi2013HistopathologyOG, title={ ...
Distant metastasis of gastrointestinal endocrine neoplasm is definitely resistant to available. January 20, 2019. ... Distant metastasis of gastrointestinal endocrine neoplasm is definitely resistant to available remedies. G. , Kuang W. J. , ... and its own receptors in adenocarcinomas from the gastrointestinal system . Cancer tumor Res. , 53 , 4727 C 4735 ( 1993. ). [ ...
978 Prognostic Value of Somatostatin Receptor Scintigraphy on High-Grade Neuroendocrine Neoplasms and Impact on the Treatment ... PET/CT Data in Patients with Pancreatic Neuroendocrine Neoplasm. Introduction: Ga-68 somatostatin receptor (SSTR) PET/CT is one ... Level and Somatostatin Receptor Scintigraphy of Gastroenteropancreatic Neuroendocrine Neoplasm Cases. Introduction: 99mTc-HYNIC ... could detect not only somatostatin receptors but also tumor images in patients with neuroendocrine neoplasms (NENs). ...
Primary nonlymphoid gastrointestinal neoplasms in dogs in Rio Grande do Sul Primary nonlymphoid gastrointestinal neoplasms in ... Gastrointestinal neoplasms (GIN) are uncommon in dogs, but they mainly show malignant behavior and poor prognosis. The types of ... Epithelial neoplasms showed a greater potential for lymphatic invasion whereas mesenchymal neoplasms appeared to be more ... Neoplasms occurred more frequently in purebred dogs (64.8%, 57/88), males (53.4%, 47/88), with a median age of 10 years. The ...
Sunita.Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract with a ... and we review the malignant potential of these synchronous tumors.Keywords Gastrointestinal stromal tumor, adenocarcinoma, ... who was suspected with GIST of stomach and was incidentally found to have an associated duodenal neuroendocrine neoplasm. The ... Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract with a malignant ...
Liver neoplasms (ReelDx). Abdominal pain, weight loss, right upper quadrant mass. Etiology: Cirrhosis, Hepatitis B, Hepatitis C ... Gastric Neoplasms. Abdominal pain and unexplained weight loss are the most common symptoms along with reduced appetite, ... Pancreatic neoplasms (ReelDx). Painless jaundice is pathognomonic. *Most commonly ductal adenocarcinoma located at the ... Esophageal Neoplasms. Progressive dysphagia to solid foods along with weight loss, reflux, and hematemesis ...
Neuroendocrine Neoplasms of the Gastrointestinal Tract. Background: Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) ... Neuroendocrine Neoplasms of the Gastrointestinal Tract. Dtsch Arztebl Int 2011; 108(18): 305-12; DOI: 10.3238/arztebl.2011.0305 ... Neuroendocrine neoplasms of the gastrointestinal tract. Dtsch Arztebl Int 2011; 108(18): 305 12. DOI: 10.3238/arztebl.2011.0305 ... Rindi G, Arnold R, Bosman FT, et al.: Nomenclature and classification of neuroendocrine neoplasms of the digestive system. In: ...
... refers to the group of cancers that affect the digestive system which ... Novel approaches for radiation therapy for gastrointestinal cancers. Related Conference of Gastrointestinal Neoplasms. May 26- ... Gastrointestinal Surgery:- - Clinical Gastroenterology 2021 (Germany). *Gastrointestinal Therapeutics - ASIAN GASTRO 2021 (UK) ... Gastrointestinal and Minimally Invasive Surgery - Gastroenterology 2021 (Austria). *Gastrointestinal bleeding - ASIAN GASTRO ...
Background/Aims: Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal neoplasms of the tubular ... gastrointestinal tract (GI). Here, we present a series of 32 patients diagnosed with a primary neoplasm in addition to GIST, ...
Gastrointestinal Pathology Section Intraductal Oncocytic Papillary Neoplasms of the Pancreas. Adsay, N. Volkan; Adair, Carol F ...
Gastrointestinal-system; Blood-plasma; Author Keywords: Foundry; Stomach Neoplasms; Lung Neoplasms; Lymphohematopoietic Cancer ...
In particular, endoscopic therapy for duodenal neoplasms can reduce the severity of duodenal polyposis. ... Endoscopic surveillance in FAP patients is important for the detection and treatment of upper GI neoplasms in early stage. ... Prevalence and endoscopic treatment outcomes of upper gastrointestinal neoplasms in familial adenomatous polyposis Jin Hee Noh ... Prevalence and endoscopic treatment outcomes of upper gastrointestinal neoplasms in familial adenomatous polyposis Jin Hee Noh ...
Lower gastrointestinal neuroendocrine neoplasms associated with hereditary cancer syndromes: a case series.. Kidambi TD1, ... Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally ...
... are rare neoplasms of the gastrointestinal tract. Their incidence in the esophagus is 1%-3%. Never has a GIST been documented ... From: Gastrointestinal stromal tumor masquerading as a lung neoplasm. A case presentation and literature review ...
Gastrointestinal-system-disorders; Author Keywords: asbestos; colonic neoplasms; meta-analysis; occupational diseases ...
... nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. ... nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms, ... nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. ... nonsurgical management of perforation complicating endoscopic submucosal dissection of gastrointestinal epithelial neoplasms. ...
title = "Localization of P32 as a diagnostic aid in gastrointestinal neoplasms",. keywords = "GASTROINTESTINAL SYSTEM/neoplasms ... SHAHON, D. B. ; AUST, J. B. ; ROOT, H. D. / Localization of P32 as a diagnostic aid in gastrointestinal neoplasms. In: Surgical ... SHAHON, D. B., AUST, J. B., & ROOT, H. D. (1957). Localization of P32 as a diagnostic aid in gastrointestinal neoplasms. ... SHAHON, DB, AUST, JB & ROOT, HD 1957, Localization of P32 as a diagnostic aid in gastrointestinal neoplasms, Surgical forum, ...
Neoplasms. Medullary thyroid carcinoma. Gastrointestinal Disorders. Acute pancreatitis, hemorrhagic and necrotizing ... Colorectal Neoplasms. *In Saxenda clinical trials, benign colorectal neoplasms (mostly colon adenomas) confirmed by ... Most episodes of gastrointestinal events were mild or moderate and did not lead to discontinuation of therapy (6.2% with ... Gastrointestinal Adverse Reactions. *In the clinical trials, approximately 68% of Saxenda-treated patients and 39% of placebo- ...
... gastrointestinal cancer; heart diseases; lung cancer; mortality; motor vehicle industry; neoplasms; nitroso amines; oil mist; ... Topics: cancer; cardiovascular diseases; gastrointestinal cancer; Germany; long-term study; mortality; motor vehicle industry. ... Topics: bladder tumour; cancer; cirrhosis; coolants; diabetes mellitus; emphysema; epidemiologic study; gastrointestinal cancer ...
Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. Ann Surg Oncol. 2012;19:1386-93.PubMed ... Gastrointestinal Oncology. First Online: 11 June 2014. Abstract. Background. Obesity has been described as a risk factor for ... New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? Lancet Oncol. 2006;7:69-76. ... Consensus statement on the loco-regional treatment of appendiceal mucinous neoplasms with peritoneal dissemination ( ...
The small intestine or small bowel is an organ in the gastrointestinal tract where most of the end absorption of nutrients and ... See also: Gastrointestinal disease. The small intestine is a complex organ, and as such, there are a very large number of ... "The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling ... Neoplasms (cancers) *Adenocarcinoma. *Carcinoid. *Gastrointestinal stromal tumor (GIST). *Lymphoma. *Sarcoma. *Leiomyoma. * ...
Results of search for su:{Gastrointestinal neoplasms} and location:BORROWABLE-COLL-STACKS ... Gastrointestinal cancer / edited by Jerome J. DeCosse and Paul Sherlock.1, . by DeCosse, Jerome J , Sherlock, Paul ... Nutrition in gastrointestinal disease / edited by Robert C. Kurtz.. by Kurtz, Robert C ... Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds.). by Schlag, Peter , ...
  • Thomas P. Plesec, "Gastrointestinal Mesenchymal Neoplasms other than Gastrointestinal Stromal Tumors: Focusing on Their Molecular Aspects," Pathology Research International , vol. 2011, Article ID 952569, 10 pages, 2011. (hindawi.com)
  • Gastrointestinal stromal tumors (GISTs) are relatively rare neoplasms of the gastrointestinal tract originating from the pluripotential mesenchymal stem cells, which differentiate into interstitial Cajal cells. (dovepress.com)
  • The therapeutic approach to locally developed gastrointestinal stromal tumors is surgical resection, either with open or laparoscopic surgery. (dovepress.com)
  • The most frequently diagnosed neoplasms were papillary adenocarcinoma (19.3%, 17/88), leiomyosarcoma (17.0%, 15/88), gastrointestinal stromal tumors (GISTs) (12.5%, 11/88), and leiomyoma (5.0%, 8/88). (bvsalud.org)
  • Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasms of the gastrointestinal tract with a malignant potential. (openarchives.gr)
  • Background/Aims: Gastrointestinal stromal tumors (GISTs) are the most common primary mesenchymal neoplasms of the tubular gastrointestinal tract (GI). (medeniyet.edu.tr)
  • Circulating Cell-free Tumor DNA in the Plasma of Patients With Gastrointestinal Stromal Tumors (GIST): Detection and Correlation With Disease Status Assessed by Conventional Technique. (clinicaltrials.gov)
  • For multiple neoplasms of the same site that are not contiguous, such as tumors in different quadrants of the same breast, codes for each site should be assigned. (icd10data.com)
  • How Are Gastrointestinal Stromal Tumors Diagnosed? (medlineplus.gov)
  • How Are Gastrointestinal Stromal Tumors Staged? (medlineplus.gov)
  • What Are the Risk Factors for Gastrointestinal Stromal Tumors? (medlineplus.gov)
  • Do We Know What Causes Gastrointestinal Stromal Tumors? (medlineplus.gov)
  • Gastro- entero-pancreatic neuroendocrine neoplasms are a heterogeneous group of epithelial tumors with a steady increase in incidence and prevalence. (jgld.ro)
  • Endoscopic submucosal dissection (ESD) was developed to resect larger tumors and aid in achieving higher rates of en-bloc resection than would be possible with EMR. (medscape.com)
  • EPIGIST: An observational real-life study on patients with metastatic gastrointestinal stromal tumors receiving imatinib. (bioportfolio.com)
  • Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. (bioportfolio.com)
  • Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs. (bioportfolio.com)
  • Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. (bioportfolio.com)
  • Although intraductal papillary mucinous neoplasms are benign tumors, they can progress to pancreatic cancer. (wikipedia.org)
  • Clinical evaluation includes gastrointestinal tract recovery of function, pain relief, life quality improvement. (centerwatch.com)
  • Gastrointestinal neuroendocrine neoplasms (GI-NENs) arise from neuroendocrine cells distributed mainly in the mucosa and submucosa of the gastrointestinal tract. (semanticscholar.org)
  • Endocrine tumours of the gastrointestinal tract: aetiology, molecular pathogenesis and genetics. (semanticscholar.org)
  • The small intestine or small bowel is an organ in the gastrointestinal tract where most of the end absorption of nutrients and minerals from food takes place. (wikipedia.org)
  • Combined modality therapy of gastrointestinal tract cancer / P. Schlag, P. Hohenberger, U. Metzger (eds. (who.int)
  • A thorough understanding of the cutaneous/gastrointestinal (GI) relationship can alert the astute clinician to occult disease within the GI tract. (medscape.com)
  • EUS uses miniaturized ultrasound probes inserted into the bile duct or the upper and lower gastrointestinal tract to provide detailed images that aid in the diagnosis of HPB conditions as well as the staging of patients with esophageal, gastric and rectal cancers. (ohsu.edu)
  • The epidemiologic situation regarding malignant neoplasms of the gastrointestinal tract in the communities of Mali Idos and Backa Topola prior to mass screening of the population]. (semanticscholar.org)
  • Endoscopic mucosal resection (EMR) is a technique used for the staging and treatment of superficial neoplasms of the gastrointestinal (GI) tract. (medscape.com)
  • In addition to the pineal gland, melatonin is also synthesized in the retina, bone marrow, gastrointestinal tract, and bile ( 2 ). (aacrjournals.org)
  • Patients referred by endosonography with bulging of upper gastrointestinal tract were studied retrospectively. (scielo.br)
  • An Update on the Role of Immunohistochemistry in the Evaluation of Gastrointestinal Tract Disorders. (bioportfolio.com)
  • Differential diagnosis of mesenchymal neoplasms of the digestive tract by cell block and immunohistochemistry. (bioportfolio.com)
  • To evaluate the diagnostic yield of the cell block (CB) technique with immunohistochemistry in patients with mesenchymal neoplasms of the gastrointestinal tract collected by endoscopic ultrasound-guid. (bioportfolio.com)
  • It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (bioportfolio.com)
  • Technological advances, such as high-resolution manometry (HRM), now provide objective measurements not only of motility, but also of function in terms of the movement (and digestion) of ingested material within the gastrointestinal tract. (ueg.eu)
  • The initial assessment of patients with gastrointestinal symptoms must identify 'alarm features' that could indicate the presence of neoplasia, ulceration or inflammation in the digestive tract and require urgent endoscopy and/or imaging (figure 1). (ueg.eu)
  • Background: To study occurrence, age and sex distribution, to evaluate and to correlate the various histopathological features of surgical specimens of gastrointestinal tract tumours received at pathology department of GMERS medical college, Gandhinagar (Gujarat, India). (pacificejournals.com)
  • Methods: A histopathological study of gastrointestinal tract tumours of 64 cases was carried out on surgical specimens at GMERS medical college, Gandhinagar from January-2018 to May-2019. (pacificejournals.com)
  • 3. Mohammad A, Makaju R. Retrospective histopathological analysis of various neoplasms of different parts of the gastrointestinal tract seen at the Kathmandu University Teaching Hospital (KUTH). (pacificejournals.com)
  • Diagnosis of Gastrointestinal tumours usually requires endoscopy , followed by biopsy of suspicious tissue. (gastroconferences.com)
  • Although upper gastrointestinal (GI) neoplasms are not rare in patients with familial adenomatous polyposis (FAP), few studies have focused on them and the long-term outcomes of their treatment by endoscopy. (cdc.gov)
  • Pathology reports from 1655 patients who had upper gastrointestinal endoscopy and biopsy according to a systematic protocol were reviewed. (nih.gov)
  • The identification of a bulging covered by normal epithelium is a common finding during an upper gastrointestinal endoscopy. (scielo.br)
  • She underwent an upper gastrointestinal endoscopy, finding several erythematous polypoid lesions in the body of the stomach, around 2 to 6 mm of diameter, with cerebroid features, without active bleeding at the moment of the exploration. (isciii.es)
  • Endoscopy should also be performed in patients who have an existing functional gastrointestinal disease (FGID) diagnosis if alarm features develop, in patients who have severe symptoms that fail to respond to therapy and if there is a persistent change in symptoms during follow up. (ueg.eu)
  • The burden of upper gastrointestinal endoscopy in patients with Barrett's esophagus. (biomedsearch.com)
  • BACKGROUND AND STUDY AIMS: Patients with Barrett's esophagus are recommended to undergo regular surveillance with upper gastrointestinal endoscopy, an invasive procedure that may cause anxiety, pain, and discomfort. (biomedsearch.com)
  • CONCLUSIONS: Upper gastrointestinal endoscopy is burdensome for many patients with Barrett's esophagus and causes moderate distress. (biomedsearch.com)
  • Gastrointestinal Neoplasms refers to the group of cancers that affect the digestive system which includes cancers of the oesophagus, gallbladder, liver, pancreas, stomach, small intestine, bowel and anus. (gastroconferences.com)
  • Malignant neoplasms of ectopic tissue are to be coded to the site mentioned, e.g., ectopic pancreatic malignant neoplasms are coded to pancreas, unspecified ( C25.9 ). (icd10data.com)
  • Specific sections deal with Physiology and Pathophysiology, Clinical Presentation of Disease, Clinical Manifestations and Management (discussing the Mouth and Esophagus, The Stomach and Duodenum, The Intestine, and The Pancreas), Diagnosis of Gastrointestinal Diseases, and Principles of Therapy. (ecampus.com)
  • Clinicopathological features of patients with concomitant intraductal papillary mucinous neoplasm of the pancreas and pancreatic endocrine neoplasm. (nih.gov)
  • Endocrine tumor and intraductal papillary mucinous neoplasm of the pancreas: a fortuitous association? (nih.gov)
  • Pancreatic mucinous cystic neoplasm (MCN) is a type of cystic lesion that occurs in the pancreas. (wikipedia.org)
  • Co-existence of Gastrointestinal Stromal. (medeniyet.edu.tr)
  • Gastrointestinal stromal tumor masquerading as a lung neoplasm. (biomedcentral.com)
  • To determine the anti-tumour activity and biological effects of cediranib (AZD2171) at a dose of 45mg, primarily in Gastrointestinal Stromal Tumour (GIST) patients who are resistant to imatinib mesylate (current standard therapy) and also in patients with metastatic Soft Tissue Sarcoma (STS) resistant to standard therapy. (clinicaltrials.gov)
  • Change in Standardised Uptake Value (SUV)Max at Day 8, Central Review, (GIST) Gastrointestinal Stromal Tumours Patients. (clinicaltrials.gov)
  • What Happens After Treatment for Gastrointestinal Stromal Tumor? (medlineplus.gov)
  • The first case is of a 50-year-old male patient who was suspected with GIST of stomach and was incidentally found to have an associated duodenal neuroendocrine neoplasm. (openarchives.gr)
  • Here, we present a series of 32 patients diagnosed with a primary neoplasm in addition to GIST, from six different institutions in Turkey. (medeniyet.edu.tr)
  • Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M. Characterization of a side population of cancer cells from human gastrointestinal system. (umassmed.edu)
  • I. Rodent models of infectious gastrointestinal and liver cancer. (umassmed.edu)
  • Symptoms of Gastrointestinal cancer related to the organ affected and can cause difficulty in swallowing or defecating, abnormal bleeding or other associated problems. (gastroconferences.com)
  • Treatment for Gastrointestinal cancer will depend on the type of cancer, the stage or its development, and other health factors. (gastroconferences.com)
  • Gastrointestinal cancer is the most common form of cancer. (gastroconferences.com)
  • Among the enrolled patients, 113 (54.3%) had one or more upper GI neoplasms: gastric adenoma (n = 34), gastric cancer (n = 7), nonampullary duodenal adenoma (n = 86), and ampullary adenoma (n = 53). (cdc.gov)
  • Lower gastrointestinal neuroendocrine neoplasms associated with hereditary cancer syndromes: a case series. (cdc.gov)
  • Lower gastrointestinal (GI) neuroendocrine neoplasms (NENs) of the colon and rectum are uncommon and not traditionally associated with hereditary GI cancer syndromes. (cdc.gov)
  • Gastrointestinal cancer / edited by Jerome J. DeCosse and Paul Sherlock. (who.int)
  • An early gastrointestinal reaction was graded using the National Cancer Institute Common Toxicity Criteria, version 2. (osti.gov)
  • Case presentation We report the case of a 67 year-old-woman who presented with gastrointestinal symptoms which revealed to be the clinical manifestations of peritoneal and retroperitoneal metastatic spread of an invasive lobular breast cancer diagnosed 15 years before. (doaj.org)
  • Gastrointestinal complications (e.g., constipation, bowel obstruction, diarrhea) can be tumor or treatment related and are common in cancer patients. (oncolink.org)
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the pathophysiology and treatment of gastrointestinal complications, including constipation, impaction, bowel obstruction, diarrhea, and radiation enteritis. (oncolink.org)
  • This technique was first developed in Japan for the treatment of early gastric cancer (EGC) and has since spread in use throughout the world for various indications, including dysplastic Barrett mucosa and sessile colonic neoplasms. (medscape.com)
  • It has been suggested that the occurrence of intraductal papillary mucinous neoplasms in association with pancreatic endocrine tumours is more frequent than expected [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. (nih.gov)
  • Up to now, 10 patients with concomitant intraductal papillary mucinous neoplasms and pancreatic endocrine tumours have been reported [Goh BK, Ooi LL, Kumarasinghe MP, Tan YM, Cheow PC, Chow PK, et al. (nih.gov)
  • We report two additional patients with intraductal papillary mucinous neoplasms and pancreatic endocrine tumours, in whom both tumours were diagnosed before surgery. (nih.gov)
  • The vast majority of patients with renal cell carcinoma developing gastric metastases showed symptoms as microcytic anaemia or upper gastrointestinal haemorrhage, dyspepsia or abdominal pain, similar to those patients with primary gastric tumours. (isciii.es)
  • Conclusion: The occurrence of gastrointestinal tumours was highest in the colon and rectum accounting for 53.12% of cases with most common variety being epithelial. (pacificejournals.com)
  • As Gastrointestinal tumours show a wide variation in the morphology, histopathological examination is must for the diagnosis and typing of these tumours. (pacificejournals.com)
  • Gastrointestinal malignant tumours in Amritsar (Punjab). (pacificejournals.com)
  • 9. Leena Devi KK, Suvarna N. Patterns of Gastrointestinal tumours in North Kerala. (pacificejournals.com)
  • Malignant Gastrointestinal Tumours in western Nigeria: A Histopathologic analysis of 713 cases. (pacificejournals.com)
  • 13. Devi KR, Suvarna N. Pattern of gastrointestinal tumours in North Kerala. (pacificejournals.com)
  • Major indications for the procedures were acute recurrent or chronic mid-gastrointestinal bleeding (n=71), suspected gastrointestinal tumours (n=10), suspected Crohn's disease (n=6), chronic abdominal pain and/or chronic diarrhoea (n=8), refractory celiac disease (n=5). (biomedsearch.com)
  • Does Obesity Affect Outcomes of Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemoperfusion for Disseminated Mucinous Appendiceal Neoplasms? (springer.com)
  • Our objective was to investigate the impact of being overweight or obese on perioperative and oncologic outcomes after cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemoperfusion (HIPEC) for peritoneal carcinomatosis (PC) from mucinous appendiceal neoplasms (MAN). (springer.com)
  • Aggressive management of peritoneal carcinomatosis from mucinous appendiceal neoplasms. (springer.com)
  • Histopathologic findings of multifocal pancreatic intraductal papillary mucinous neoplasms on CT. (hopkinsmedicine.org)
  • Amongst individuals undergoing surgical resection of a pancreatic cyst, about 23 percent were mucinous cystic neoplasms. (wikipedia.org)
  • Where possible, surgical resection of mucinous cystic neoplasms is preferable. (wikipedia.org)
  • Intraductal papillary mucinous neoplasm (IPMN) is a type of tumor that can occur within the cells of the pancreatic duct. (wikipedia.org)
  • Once an intraductal papillary mucinous neoplasm has been found, the management options include close monitoring and pre-emptive surgery. (wikipedia.org)
  • A primary malignant neoplasm that overlaps two or more contiguous (next to each other) sites should be classified to the subcategory/code .8 ('overlapping lesion'), unless the combination is specifically indexed elsewhere. (icd10data.com)
  • Objective: The reports of multiple primary malignant neoplasm (MPMN) have increased due to the development of imaging technologies that have influenced the extension of the 5-year relative survival rate for all cancers. (elsevier.com)
  • Conclusions FDG PET/CT was useful for finding multiple primary malignant neoplasm with a relatively high sensitivity. (elsevier.com)
  • Kishimoto, G, Murakami, K & Sakamoto, S 2011, ' Preoperative diagnosis of multiple primary malignant neoplasm in gastrointestinal and breast cancers: Impact of FDG-PET/CT ', Dokkyo Journal of Medical Sciences , vol. 38, no. 1, pp. 9-16. (elsevier.com)
  • This Phase I study will evaluate the safety of escalating temperatures of continuous hyperthermic peritoneal perfusion (CHPP) with escalating doses of intraperitoneal Cisplatin (CDDP) in the treatment of patients with advanced peritoneal adenocarcinoma of gastrointestinal origin. (clinicaltrials.gov)
  • Patients with histologically proven gastrointestinal adenocarcinoma, mesothelioma, or sarcoma. (clinicaltrials.gov)
  • With the development and maturation of endoscopic management, endoscopic mucosal resection (EMR), endoscopic submucosal dissection (ESD), submucosal tunneling endoscopic resection (STER) and laparoscopic-endoscopic cooperative surgery (LECS) show absolute advantages in minimal invasion and functional preservation in the treatment of colorectal neoplasms . (bvsalud.org)
  • More and more endoscopic managements are carried out to treat colorectal neoplasms . (bvsalud.org)
  • The aim of this article is to summarize the application of endoscopic management for colorectal neoplasms . (bvsalud.org)
  • The correlation between chronic constipation and colorectal neoplasms has been arousing wide interest. (bvsalud.org)
  • melanosis coli (MC), laxatives and colorectal neoplasms . (bvsalud.org)
  • Endoscopic submucosal dissection (ESD) is a newly developed technique in the field of endoscopic treatment for GI neoplasms, because of its high rate of en bloc resection. (clinicaltrials.gov)
  • Endoscopic mucosal resection (EMR) is widely accepted as a minimally invasive treatment for GI neoplasms.However, one disadvantage of EMR is that lesions larger than 2 cm in diameter must be removed in pieces, which may result in a high recurrence rate of residual tumor tissue. (clinicaltrials.gov)
  • Therefore, we aimed to investigate the prevalence and endoscopic treatment outcomes of upper GI neoplasms in patients with FAP. (cdc.gov)
  • The clinical features and endoscopic treatment outcomes of upper GI neoplasms were retrospectively investigated and analyzed. (cdc.gov)
  • Among patients with gastric neoplasms (n = 37), 24 (64.9%) underwent treatment (endoscopic treatment: 22, surgery: 2). (cdc.gov)
  • Background and study aims: Endoscopic submucosal dissection (ESD) is a novel technique used for the treatment of gastrointestinal neoplasia. (elsevier.com)
  • Institutional experience with solid pseudopapillary neoplasms: focus on computed tomography, magnetic resonance imaging, conventional ultrasound, endoscopic ultrasound, and predictors of aggressive histologys. (hopkinsmedicine.org)
  • To compare the endoscopic and endosonography findings in the differential diagnosis of the gastrointestinal bulging (subepithelial tumor or extrinsic compression). (scielo.br)
  • In this chapter, we will review the diagnosis and treatment of both the common and the more unusual neoplasms. (springer.com)
  • Including en bloc and curative resection rate, the specimen size, complications, lateral and vertical margin exposure of tumor, and lymphatic or vascular invasion. (clinicaltrials.gov)
  • Somatostatin receptor scintigraphy (SRS) could detect not only somatostatin receptors but also tumor images in patients with neuroendocrine neoplasms (NENs). (enets.org)
  • A neoplasm or tumor is a group of cells that have undergone unregulated growth and will often form a mass or lump, but may be distributed diffusely. (wikipedia.org)
  • Taking into consideration their role in cell differentiation, cell proliferation, apoptosis and tumor development, microRNAs have gained interest as potential prognostic markers and treatment response predictors in neuroendocrine neoplasms. (jgld.ro)
  • Patients and methods: We included in our study all the cases of perforation that occurred during ESID procedures for gastrointestinal epithelial neoplasia between February 2000 and February 2005. (elsevier.com)
  • Increased susceptibility to infection and the possible development of lymphoma and other neoplasms may result from the increase in the degree of immunosuppression in transplant patients. (rxlist.com)
  • We report results of using isolated hepatic perfusion (IHP) in patients with advanced progressive liver metastases (LM) from pancreatic and gastrointestinal neuroendocrine neoplasms (NENs). (elsevier.com)
  • Patients with a solitary gastric neoplasm were enrolled. (bmj.com)
  • The purpose of this study is to define the recommended dose of BMS-582664 that could be safely combined with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) or 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy regimens in patients with advanced gastrointestinal malignancies and to evaluate the safety profile, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of these combinations. (bioportfolio.com)
  • Most patients with these symptoms do not have neoplasia, infection or inflammation on initial investigation, but rather so-called functional gastrointestinal symptoms. (ueg.eu)
  • Ahlquist, David A. / Fecal Recovery of Ingested Cellular DNA : Implications for Noninvasive Detection of Upper Gastrointestinal Neoplasms . (elsevier.com)
  • Late colonic metastasis from renal cell carcinoma are uncommon too, but has been described presenting as a lower gastrointestinal haemorrhage or, less frequent, as an intra-abdominal bled (6). (isciii.es)
  • Gastroenteric neuroendocrine neoplasms (GE-NENs) display highly variable clinical behavior. (wiley.com)
  • 10. Jamal S, Mamoon N, Mushtaq S, Luqman M. Analysis of gastrointestinal malignancies at the Armed Forces Institute of Pathology (AFIP), Rawalpindi, Pakistan. (pacificejournals.com)
  • Epithelial neoplasms showed a greater potential for lymphatic invasion whereas mesenchymal neoplasms appeared to be more expansive with intratumoral necrosis and hemorrhage . (bvsalud.org)
  • The incidence of benign neoplasms among the survivors exposed within 1500 meters is also significantly higher than that among the non-exposed. (osti.gov)
  • Dr. Kawamoto's research focuses on body CT and biopsy, particularly imaging of the genitourinary and gastrointestinal systems. (hopkinsmedicine.org)
  • New standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome? (springer.com)
  • Epithelial neoplasms of the stomach. (medlineplus.gov)
  • Here, I discuss frequent mistakes in clinical investigation of gastrointestinal motility and function based on a series of consensus documents published by members of the International Working Group for Disorders of Gastrointestinal Motility and Function. (ueg.eu)
  • He had undergone left nephrectomy and splenectomy for abdominal trauma and had had three episodes of lower gastrointestinal bleeding for which blood transfusions had been required. (cmaj.ca)
  • The patient with a fecal impaction may present with circulatory, cardiac, or respiratory symptoms rather than with gastrointestinal symptoms. (cancer.gov)
  • The dose escalation schedule in Table 1 should be used to reduce the likelihood of gastrointestinal symptoms. (rxlist.com)
  • Symptoms related to abnormal gastrointestinal motility and function can occur from the moment food is swallowed to the time stool is passed into the toilet. (ueg.eu)
  • Dr. Shcherba has more experience with Pancreatic Neoplasms, Gastrointestinal Neoplasms, and Pulmonary Neoplasms than other specialists in her area. (healthgrades.com)
  • Dr. Shcherba frequently treats Pancreatic Neoplasms, Gastrointestinal Neoplasms, and Pulmonary Neoplasms. (healthgrades.com)
  • Kaposi sarcoma (KS) is a neoplasm of vascular endothelial and lymphoreticular cells that can involve the skin and numerous visceral organs. (medscape.com)
  • Curt A, Popa Ilie I, Cainap C, Balacescu O, Ghervan C. MicroRNAs and Treatment with Somatostatin Analogs in Gastro- Entero-Pancreatic Neuroendocrine Neoplasms: Challenges in Personalized Medicine. (jgld.ro)
  • This review is the first to summarize the available data on the possible role of microRNAs in evaluating the efficacy of somatostatin analogs treatment in gastro- entero-pancreatic neuroendocrine neoplasms. (jgld.ro)