Gastrointestinal carcinoid tumors. Medical search

A usually small, slow-growing neoplasm composed of islands of rounded, oxyphilic, or spindle-shaped cells of medium size, with moderately small vesicular nuclei, and covered by intact mucosa with a yellow cut surface. The tumor can occur anywhere in the gastrointestinal tract (and in the lungs and other sites); approximately 90% arise in the appendix. It is now established that these tumors are of neuroendocrine origin and derive from a primitive stem cell. (From Stedman, 25th ed & Holland et al., Cancer Medicine, 3d ed, p1182)

Tumors or cancer of the GASTROINTESTINAL TRACT, from the MOUTH to the ANAL CANAL.

Tumors or cancer of the APPENDIX.

A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)

Cardiac manifestation of gastrointestinal CARCINOID TUMOR that metastasizes to the liver. Substances secreted by the tumor cells, including SEROTONIN, promote fibrous plaque formation in ENDOCARDIUM and its underlying layers. These deposits cause distortion of the TRICUSPID VALVE and the PULMONARY VALVE eventually leading to STENOSIS and valve regurgitation.

Tumors or cancer in the ILEUM region of the small intestine (INTESTINE, SMALL).

Tumors or cancer of the BRONCHI.

Hydroxyindoleacetic acid (5HIAA) is a major metabolite of serotonin, a neurotransmitter, formed by the action of monoamine oxidase and aldehyde dehydrogenase, and its measurement in urine is often used as a biomarker for serotonin synthesis in clinical and research settings.

Tumors or cancer of the INTESTINES.

A group of acidic proteins that are major components of SECRETORY GRANULES in the endocrine and neuroendocrine cells. They play important roles in the aggregation, packaging, sorting, and processing of secretory protein prior to secretion. They are cleaved to release biologically active peptides. There are various types of granins, usually classified by their sources.

A potent, long-acting synthetic SOMATOSTATIN octapeptide analog that inhibits secretion of GROWTH HORMONE and is used to treat hormone-secreting tumors; DIABETES MELLITUS; HYPOTENSION, ORTHOSTATIC; HYPERINSULINISM; hypergastrinemia; and small bowel fistula.

Tumors whose cells possess secretory granules and originate from the neuroectoderm, i.e., the cells of the ectoblast or epiblast that program the neuroendocrine system. Common properties across most neuroendocrine tumors include ectopic hormone production (often via APUD CELLS), the presence of tumor-associated antigens, and isozyme composition.

A type of chromogranin which was first isolated from CHROMAFFIN CELLS of the ADRENAL MEDULLA but is also found in other tissues and in many species including human, bovine, rat, mouse, and others. It is an acidic protein with 431 to 445 amino acid residues. It contains fragments that inhibit vasoconstriction or release of hormones and neurotransmitter, while other fragments exert antimicrobial actions.

Symptom complex due to ACTH production by non-pituitary neoplasms.

Tumors or cancer of the LUNG.

Directions or principles presenting current or future rules of policy for assisting health care practitioners in patient care decisions regarding diagnosis, therapy, or related clinical circumstances. The guidelines may be developed by government agencies at any level, institutions, professional societies, governing boards, or by the convening of expert panels. The guidelines form a basis for the evaluation of all aspects of health care and delivery.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

Conformity in fulfilling or following official, recognized, or institutional requirements, guidelines, recommendations, protocols, pathways, or other standards.

A group of carcinomas which share a characteristic morphology, often being composed of clusters and trabecular sheets of round "blue cells", granular chromatin, and an attenuated rim of poorly demarcated cytoplasm. Neuroendocrine tumors include carcinoids, small ("oat") cell carcinomas, medullary carcinoma of the thyroid, Merkel cell tumor, cutaneous neuroendocrine carcinoma, pancreatic islet cell tumors, and pheochromocytoma. Neurosecretory granules are found within the tumor cells. (Segen, Dictionary of Modern Medicine, 1992)

A carcinoid tumor is a type of slow-growing neuroendocrine tumor that usually originates in the digestive tract, particularly in the small intestine. These tumors can also arise in other areas such as the lungs, appendix, and rarely in other organs. Carcinoid tumors develop from cells of the diffuse endocrine system (also known as the neuroendocrine system) that are capable of producing hormones or biologically active amines.

Carcinoid tumors can produce and release various hormones and bioactive substances, such as serotonin, histamine, bradykinins, prostaglandins, and tachykinins, which can lead to a variety of symptoms. The most common syndrome associated with carcinoid tumors is the carcinoid syndrome, characterized by flushing, diarrhea, abdominal cramping, and wheezing or difficulty breathing.

Carcinoid tumors are typically classified as functional or nonfunctional based on whether they produce and secrete hormones that cause symptoms. Functional carcinoid tumors account for approximately 30% of cases and can lead to the development of carcinoid syndrome, while nonfunctional tumors do not produce significant amounts of hormones and are often asymptomatic until they grow large enough to cause local or distant complications.

Treatment options for carcinoid tumors depend on the location, size, and extent of the tumor, as well as whether it is functional or nonfunctional. Treatment may include surgery, medications (such as somatostatin analogs, chemotherapy, or targeted therapies), and radiation therapy. Regular follow-up with imaging studies and biochemical tests is essential to monitor for recurrence and assess treatment response.

Gastrointestinal (GI) neoplasms refer to abnormal growths in the gastrointestinal tract, which can be benign or malignant. The gastrointestinal tract includes the mouth, esophagus, stomach, small intestine, large intestine, rectum, and anus.

Benign neoplasms are non-cancerous growths that do not invade nearby tissues or spread to other parts of the body. They can sometimes be removed completely and may not cause any further health problems.

Malignant neoplasms, on the other hand, are cancerous growths that can invade nearby tissues and organs and spread to other parts of the body through the bloodstream or lymphatic system. These types of neoplasms can be life-threatening if not diagnosed and treated promptly.

GI neoplasms can cause various symptoms, including abdominal pain, bloating, changes in bowel habits, nausea, vomiting, weight loss, and anemia. The specific symptoms may depend on the location and size of the neoplasm.

There are many types of GI neoplasms, including adenocarcinomas, gastrointestinal stromal tumors (GISTs), lymphomas, and neuroendocrine tumors. The diagnosis of GI neoplasms typically involves a combination of medical history, physical examination, imaging studies, and biopsy. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or immunotherapy.

Appendiceal neoplasms refer to various types of tumors that can develop in the appendix, a small tube-like structure attached to the large intestine. These neoplasms can be benign or malignant and can include:

1. Adenomas: These are benign tumors that arise from the glandular cells lining the appendix. They are usually slow-growing and may not cause any symptoms.
2. Carcinoids: These are neuroendocrine tumors that arise from the hormone-producing cells in the appendix. They are typically small and slow-growing, but some can be aggressive and spread to other parts of the body.
3. Mucinous neoplasms: These are tumors that produce mucin, a slippery substance that can cause the appendix to become distended and filled with mucus. They can be low-grade (less aggressive) or high-grade (more aggressive) and may spread to other parts of the abdomen.
4. Adenocarcinomas: These are malignant tumors that arise from the glandular cells lining the appendix. They are relatively rare but can be aggressive and spread to other parts of the body.
5. Pseudomyxoma peritonei: This is a condition in which mucin produced by an appendiceal neoplasm leaks into the abdominal cavity, causing a jelly-like accumulation of fluid and tissue. It can be caused by both benign and malignant tumors.

Treatment for appendiceal neoplasms depends on the type and stage of the tumor, as well as the patient's overall health. Treatment options may include surgery, chemotherapy, or radiation therapy.

Malignant carcinoid syndrome is a complex of symptoms that occur in some people with malignant tumors (carcinoids) that secrete large amounts of hormone-like substances, particularly serotonin. These symptoms can include flushing of the face and upper body, diarrhea, rapid heartbeat, difficulty breathing, and abdominal pain and distention. In addition, these individuals may have chronic inflammation of the heart valves (endocarditis) leading to heart failure. It is important to note that not all people with carcinoid tumors will develop malignant carcinoid syndrome, but those who do require specific treatment for their symptoms and hormonal imbalances.

Carcinoid heart disease is a rare complication that occurs in some people with carcinoid tumors, which are slow-growing tumors that typically originate in the digestive tract. These tumors can release hormones and other substances into the bloodstream, which can cause various symptoms. In carcinoid heart disease, these substances cause fibrous plaques to form on the heart valves, leading to thickening and stiffening of the valve leaflets. This can result in leakage or obstruction of the heart valves, causing symptoms such as shortness of breath, fatigue, and fluid retention. Carcinoid heart disease is most commonly affects the tricuspid and pulmonary valves, which are located on the right side of the heart. If left untreated, carcinoid heart disease can lead to serious complications, including heart failure. Treatment typically involves a combination of medications to manage symptoms and control the growth of the tumor, as well as surgery to repair or replace damaged heart valves.

Ileal neoplasms refer to abnormal growths in the ileum, which is the final portion of the small intestine. These growths can be benign or malignant (cancerous). Common types of ileal neoplasms include:

1. Adenomas: These are benign tumors that can develop in the ileum and have the potential to become cancerous over time if not removed.
2. Carcinoids: These are slow-growing neuroendocrine tumors that typically start in the ileum. They can produce hormones that cause symptoms such as diarrhea, flushing, and heart problems.
3. Adenocarcinomas: These are malignant tumors that develop from the glandular cells lining the ileum. They are relatively rare but can be aggressive and require prompt treatment.
4. Lymphomas: These are cancers that start in the immune system cells found in the ileum's lining. They can cause symptoms such as abdominal pain, diarrhea, and weight loss.
5. Gastrointestinal stromal tumors (GISTs): These are rare tumors that develop from the connective tissue of the ileum's wall. While most GISTs are benign, some can be malignant and require treatment.

It is important to note that early detection and treatment of ileal neoplasms can significantly improve outcomes and prognosis. Regular screenings and check-ups with a healthcare provider are recommended for individuals at higher risk for developing these growths.

Bronchial neoplasms refer to abnormal growths or tumors in the bronchi, which are the large airways that lead into the lungs. These neoplasms can be benign (non-cancerous) or malignant (cancerous). Malignant bronchial neoplasms are often referred to as lung cancer and can be further classified into small cell lung cancer and non-small cell lung cancer, depending on the type of cells involved.

Benign bronchial neoplasms are less common than malignant ones and may include growths such as papillomas, hamartomas, or chondromas. While benign neoplasms are not cancerous, they can still cause symptoms and complications if they grow large enough to obstruct the airways or if they become infected.

Treatment for bronchial neoplasms depends on several factors, including the type, size, location, and stage of the tumor, as well as the patient's overall health and medical history. Treatment options may include surgery, radiation therapy, chemotherapy, or a combination of these approaches.

Hydroxyindoleacetic acid (5HIAA) is a major metabolite of the neurotransmitter serotonin, formed in the body through the enzymatic degradation of serotonin by monoamine oxidase and aldehyde dehydrogenase. 5HIAA is primarily excreted in the urine and its measurement can be used as a biomarker for serotonin synthesis and metabolism in the body.

Increased levels of 5HIAA in the cerebrospinal fluid or urine may indicate conditions associated with excessive serotonin production, such as carcinoid syndrome, while decreased levels may be seen in certain neurodegenerative disorders, such as Parkinson's disease. Therefore, measuring 5HIAA levels can have diagnostic and therapeutic implications for these conditions.

Intestinal neoplasms refer to abnormal growths in the tissues of the intestines, which can be benign or malignant. These growths are called neoplasms and they result from uncontrolled cell division. In the case of intestinal neoplasms, these growths occur in the small intestine, large intestine (colon), rectum, or appendix.

Benign intestinal neoplasms are not cancerous and often do not invade surrounding tissues or spread to other parts of the body. However, they can still cause problems if they grow large enough to obstruct the intestines or cause bleeding. Common types of benign intestinal neoplasms include polyps, leiomyomas, and lipomas.

Malignant intestinal neoplasms, on the other hand, are cancerous and can invade surrounding tissues and spread to other parts of the body. The most common type of malignant intestinal neoplasm is adenocarcinoma, which arises from the glandular cells lining the inside of the intestines. Other types of malignant intestinal neoplasms include lymphomas, sarcomas, and carcinoid tumors.

Symptoms of intestinal neoplasms can vary depending on their size, location, and type. Common symptoms include abdominal pain, bloating, changes in bowel habits, rectal bleeding, weight loss, and fatigue. If you experience any of these symptoms, it is important to seek medical attention promptly.

Chromogranins are a group of proteins that are stored in the secretory vesicles of neuroendocrine cells, including neurons and endocrine cells. These proteins are co-released with neurotransmitters and hormones upon stimulation of the cells. Chromogranin A is the most abundant and best studied member of this protein family.

Chromogranins have several functions in the body. They play a role in the biogenesis, processing, and storage of neuropeptides and neurotransmitters within secretory vesicles. Additionally, chromogranins can be cleaved into smaller peptides, some of which have hormonal or regulatory activities. For example, vasostatin-1, a peptide derived from chromogranin A, has been shown to have vasodilatory and cardioprotective effects.

Measurement of chromogranin levels in blood can be used as a biomarker for the diagnosis and monitoring of neuroendocrine tumors, which are characterized by excessive secretion of chromogranins and other neuroendocrine markers.

Octreotide is a synthetic analogue of the natural hormone somatostatin, which is used in medical treatment. It is a octapeptide with similar effects to somatostatin, but with a longer duration of action. Octreotide is primarily used in the management of acromegaly, gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and diarrhea and flushing associated with carcinoid syndrome.

It works by inhibiting the release of several hormones, including growth hormone, insulin, glucagon, and gastrin. This results in a decrease in symptoms caused by excessive hormone secretion, such as reduced growth hormone levels in acromegaly, decreased tumor size in some GEP-NETs, and improved diarrhea and flushing in carcinoid syndrome.

Octreotide is available in several forms, including short-acting subcutaneous injections (Sandostatin®), long-acting depot intramuscular injections (Sandostatin LAR®), and a slow-release formulation for the treatment of diarrhea associated with AIDS (Mycapssa™).

The medical definition of Octreotide is:

A synthetic octapeptide analogue of somatostatin, used in the management of acromegaly, gastroenteropancreatic neuroendocrine tumors (GEP-NETs), and diarrhea and flushing associated with carcinoid syndrome. Octreotide inhibits the release of several hormones, including growth hormone, insulin, glucagon, and gastrin, leading to symptomatic improvement in these conditions. It is available as short-acting subcutaneous injections, long-acting depot intramuscular injections, and a slow-release formulation for diarrhea associated with AIDS.

Neuroendocrine tumors (NETs) are a diverse group of neoplasms that arise from cells of the neuroendocrine system, which is composed of dispersed neuroendocrine cells throughout the body, often in close association with nerves and blood vessels. These cells have the ability to produce and secrete hormones or hormone-like substances in response to various stimuli. NETs can occur in a variety of organs, including the lungs, pancreas, small intestine, colon, rectum, stomach, and thyroid gland, as well as in some less common sites such as the thymus, adrenal glands, and nervous system.

NETs can be functional or nonfunctional, depending on whether they produce and secrete hormones or hormone-like substances that cause specific symptoms related to hormonal excess. Functional NETs may give rise to a variety of clinical syndromes, such as carcinoid syndrome, Zollinger-Ellison syndrome, pancreatic neuroendocrine tumor syndrome (also known as Verner-Morrison or WDHA syndrome), and others. Nonfunctional NETs are more likely to present with symptoms related to the size and location of the tumor, such as abdominal pain, intestinal obstruction, or bleeding.

The diagnosis of NETs typically involves a combination of imaging studies, biochemical tests (e.g., measurement of serum hormone levels), and histopathological examination of tissue samples obtained through biopsy or surgical resection. Treatment options depend on the type, location, stage, and grade of the tumor, as well as the presence or absence of functional symptoms. They may include surgery, radiation therapy, chemotherapy, targeted therapy, and/or peptide receptor radionuclide therapy (PRRT).

Chromogranin A is a protein that is widely used as a marker for neuroendocrine tumors. These are tumors that arise from cells of the neuroendocrine system, which is a network of cells throughout the body that produce hormones and help to regulate various bodily functions. Chromogranin A is stored in secretory granules within these cells and is released into the bloodstream when the cells are stimulated to release their hormones.

Chromogranin A is measured in the blood as a way to help diagnose neuroendocrine tumors, monitor the effectiveness of treatment, and track the progression of the disease. Elevated levels of chromogranin A in the blood may indicate the presence of a neuroendocrine tumor, although other factors can also cause an increase in this protein.

It's important to note that while chromogranin A is a useful marker for neuroendocrine tumors, it is not specific to any one type of tumor and should be used in conjunction with other diagnostic tests and clinical evaluation.

Ectopic ACTH syndrome is a medical condition characterized by the excessive production of adrenocorticotropic hormone (ACTH) from a source outside of the pituitary gland, typically from a tumor in another part of the body. The most common sources of ectopic ACTH are small-cell lung carcinomas, but it can also occur with other types of tumors such as thymic carcinoids, pancreatic islet cell tumors, and bronchial carcinoids.

The excessive production of ACTH leads to an overproduction of cortisol from the adrenal glands, resulting in a constellation of symptoms known as Cushing's syndrome. These symptoms can include weight gain, muscle weakness, thinning of the skin, easy bruising, mood changes, and high blood pressure, among others.

Ectopic ACTH syndrome is typically more severe than pituitary-dependent Cushing's syndrome, and it may be more difficult to diagnose and treat due to the underlying tumor causing the excessive ACTH production. Treatment usually involves removing the tumor or controlling its growth, as well as managing the symptoms of Cushing's syndrome with medications that block cortisol production or action.

Lung neoplasms refer to abnormal growths or tumors in the lung tissue. These tumors can be benign (non-cancerous) or malignant (cancerous). Malignant lung neoplasms are further classified into two main types: small cell lung carcinoma and non-small cell lung carcinoma. Lung neoplasms can cause symptoms such as cough, chest pain, shortness of breath, and weight loss. They are often caused by smoking or exposure to secondhand smoke, but can also occur due to genetic factors, radiation exposure, and other environmental carcinogens. Early detection and treatment of lung neoplasms is crucial for improving outcomes and survival rates.

Practice guidelines, also known as clinical practice guidelines, are systematically developed statements that aim to assist healthcare professionals and patients in making informed decisions about appropriate health care for specific clinical circumstances. They are based on a thorough evaluation of the available scientific evidence, consensus of expert opinion, and consideration of patient preferences. Practice guidelines can cover a wide range of topics, including diagnosis, management, prevention, and treatment options for various medical conditions. They are intended to improve the quality and consistency of care, reduce unnecessary variations in practice, and promote evidence-based medicine. However, they should not replace clinical judgment or individualized patient care.

Neoplasm staging is a systematic process used in medicine to describe the extent of spread of a cancer, including the size and location of the original (primary) tumor and whether it has metastasized (spread) to other parts of the body. The most widely accepted system for this purpose is the TNM classification system developed by the American Joint Committee on Cancer (AJCC) and the Union for International Cancer Control (UICC).

In this system, T stands for tumor, and it describes the size and extent of the primary tumor. N stands for nodes, and it indicates whether the cancer has spread to nearby lymph nodes. M stands for metastasis, and it shows whether the cancer has spread to distant parts of the body.

Each letter is followed by a number that provides more details about the extent of the disease. For example, a T1N0M0 cancer means that the primary tumor is small and has not spread to nearby lymph nodes or distant sites. The higher the numbers, the more advanced the cancer.

Staging helps doctors determine the most appropriate treatment for each patient and estimate the patient's prognosis. It is an essential tool for communication among members of the healthcare team and for comparing outcomes of treatments in clinical trials.

Guideline adherence, in the context of medicine, refers to the extent to which healthcare professionals follow established clinical practice guidelines or recommendations in their daily practice. These guidelines are systematically developed statements designed to assist practitioners and patient decisions about appropriate health care for specific clinical circumstances. Adherence to evidence-based guidelines can help improve the quality of care, reduce unnecessary variations in practice, and promote optimal patient outcomes. Factors that may influence guideline adherence include clinician awareness, familiarity, agreement, self-efficacy, outcome expectancy, and the complexity of the recommendation.

Carcinoma, neuroendocrine is a type of cancer that arises from the neuroendocrine cells, which are specialized cells that have both nerve and hormone-producing functions. These cells are found throughout the body, but neuroendocrine tumors (NETs) most commonly occur in the lungs, gastrointestinal tract, pancreas, and thyroid gland.

Neuroendocrine carcinomas can be classified as well-differentiated or poorly differentiated based on how closely they resemble normal neuroendocrine cells under a microscope. Well-differentiated tumors tend to grow more slowly and are less aggressive than poorly differentiated tumors.

Neuroendocrine carcinomas can produce and release hormones and other substances that can cause a variety of symptoms, such as flushing, diarrhea, wheezing, and heart palpitations. Treatment for neuroendocrine carcinoma depends on the location and extent of the tumor, as well as the patient's overall health. Treatment options may include surgery, radiation therapy, chemotherapy, targeted therapy, or a combination of these approaches.

Most gastrointestinal carcinoid tumors tend not to respond to chemotherapy agents, showing 10 to 20% response rates that are ... Parathyroid tumors Thymus and mediastinal carcinoid tumors Pulmonary neuroendocrine tumors bronchus pulmonary carcinoid tumors ... "Carcinoid Tumors and the Carcinoid Syndrome: What's New in the Therapeutic Pipeline". Carcinoid Symposium 2002. The Carcinoid ... Small intestinal neuroendocrine tumors were first distinguished from other tumors in 1907. They were named carcinoid tumors ...

https://en.wikipedia.org/wiki/Neuroendocrine_tumor

The five-year survival rate with the latter procedure is above 70%.: 580 A gastrointestinal carcinoid tumor is a rare, slow- ... "Gastrointestinal Carcinoid Tumor". National Cancer Institute at the National Institutes of Health. 1980-01-01. Retrieved 15 ... Gastrointestinal stromal tumors represent from 1% to 3% of gastrointestinal malignancies. Cancers of the biliary tree, ... Gastrointestinal cancer refers to malignant conditions of the gastrointestinal tract (GI tract) and accessory organs of ...

https://en.wikipedia.org/wiki/Gastrointestinal_cancer

Over two-thirds of carcinoid tumors are found in the gastrointestinal tract. Carcinoid tumors are also found in the lungs. ... A carcinoid (also carcinoid tumor) is a slow-growing type of neuroendocrine tumor originating in the cells of the ... carcinoid tumors are the most common malignancy of the appendix. Carcinoid tumors may rarely arise from the ovary or thymus. ... April 2006). "Guidelines for the diagnosis and management of carcinoid tumors. Part 1: The gastrointestinal tract. A statement ...

https://en.wikipedia.org/wiki/Carcinoid

Common diseases of the appendix (in humans) are appendicitis and carcinoid tumors (appendiceal carcinoid). Appendix cancer ... preserving the flora during times of gastrointestinal infection in societies without modern medicine. This function is ... gut flora in the digestive system following a bout of dysentery or cholera or to boost it following a milder gastrointestinal ... accounts for about 1 in 200 of all gastrointestinal malignancies. In rare cases, adenomas are also present. Appendicitis is a ...

https://en.wikipedia.org/wiki/Appendix_(anatomy)

Adenocarcinoma Primary Gastric Lymphoma Gastrointestinal Stromal Tumor (GIST) Neuroendocrine (Carcinoid) Tumors Smoking ... Tumors of the stomach are known as gastric tumors, and can be either benign or malignant (gastric cancer). These tumors arise ... Malignant tumors, on the other hand, are capable of spreading throughout the entire body, causing new tumors to appear. This ... Although it is possible to have a tumor that is benign, in the case of gastric tumors, only about 5-10% end up being non- ...

https://en.wikipedia.org/wiki/Tumor_of_the_stomach

It is also effective in suppression of the carcinoid syndrome, caused by advanced or extra-gastrointestinal carcinoid tumors. ... The exact mechanism of action of these hormones is unclear, and may involve both direct effect on the tumor cells (suppression ... One effective strategy for starving tumor cells of growth- and survival-promoting hormones is to use drugs which inhibit the ... Octreotide is used for suppression of the hormonal syndromes which accompany several pancreatic islet cell tumors, including ...

https://en.wikipedia.org/wiki/Hormonal_therapy_(oncology)

"Carcinoid tumour of the gastrointestinal tract: prognostic factors and disease outcome". J Surg Oncol. 47 (1): 45-52. doi: ... Tumors derived from hindgut cells (rectal carcinoid) rarely produce excess serotonin or 5-HIAA. Of 75 patients with carcinoid ... 5-HIAA may be normal with nonmetastatic carcinoid tumor and may be normal even with the carcinoid syndrome, particularly in ... Serotonin, and consequently 5-HIAA, are produced in excess by most carcinoid tumors, especially those producing the carcinoid ...

https://en.wikipedia.org/wiki/5-Hydroxyindoleacetic_acid

Endocrine tumors of the pancreas and gastrointestinal tract. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and ... "Carcinoid Tumors and Syndrome". The Lecturio Medical Concept Library. Retrieved 5 July 2021. Sandhu S, Jialal I. "ViPoma". ... The best chance for a cure is surgery to remove the tumor. If the tumor has not spread to other organs, surgery can often cure ... However, in one-third to one-half of patients, the tumor has spread by the time of diagnosis and cannot be cured.[citation ...

https://en.wikipedia.org/wiki/VIPoma

It may be seen in Crohn's disease, hypertrophic pyloric stenosis, carcinoid tumor and colon cancer. In people with Crohn's ... The gastrointestinal string sign represents a severe narrowing of loop of bowel, in which a thin stripe of contrast within the ... String sign, or gastrointestinal string sign (also called string sign of Kantour), is a medical term for a radiographic finding ...

https://en.wikipedia.org/wiki/String_sign

... follow up Unexplained diarrhea Small Bowel masses Malignant Adenocarcinoma Carcinoid Lymphoma Gastrointestinal stromal tumor ... of many CT scans previously CT of abdomen and pelvis if unable to tolerate oral contrast MR enterography Upper gastrointestinal ...

https://en.wikipedia.org/wiki/Computed_tomography_enterography

... colon cancer and carcinoid tumors mainly of the appendix), but also from breast cancer, ovarian cancer, lung cancer, renal ... the site of origin is the gastrointestinal tract, since the liver is close to many of these metabolically active, blood-rich ... whether due to spread of the initial tumor or formation of new tumors . Liver transplantation can also be considered in cases ... In adults, these tumors are more common in males; however, in children they are more common in females. Even with surgery ...

https://en.wikipedia.org/wiki/Liver_cancer

Carcinoid tumors of the midgut-This is a type of neuroendocrine tumor (NET). They tend to be slow growing and are the most ... Gastrointestinal stromal tumor-This type of cancer starts in connective tissues. The most common sarcoma in the intestine are ... The survival rate for later stages is much lower at 4%. Early-stage carcinoid tumors have a five-year survival rate of 95%, ... A human prospective study observed a markedly elevated risk for carcinoid tumors of the small intestine associated with dietary ...

https://en.wikipedia.org/wiki/Small_intestine_cancer

Rare and slow growing carcinoid and non-carcinoid tumors develop from these cells. When a tumor arises it has the capacity to ... They produce gastrointestinal hormones or peptides in response to various stimuli and release them into the bloodstream for ... Warner RR (May 2005). "Enteroendocrine tumors other than carcinoid: a review of clinically significant advances". ... APUD cells Neuroendocrine tumors List of human cell types derived from the germ layers Rehfeld JF (October 1998). "The new ...

https://en.wikipedia.org/wiki/Enteroendocrine_cell

Adenocarcinoma Carcinoid Gastrointestinal stromal tumor (GIST) Lymphoma Sarcoma Leiomyoma Metastatic tumors, especially SCLC or ... The small intestine or small bowel is an organ in the gastrointestinal tract where most of the absorption of nutrients from ... "The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling ... ulcers Gastrointestinal perforation Hyperthyroidism Diverticulitis Radiation enterocolitis Mesenteric cysts Peritoneal ...

https://en.wikipedia.org/wiki/Small_intestine

Primary tumors Osteoblastic lesions Prostate cancer Carcinoid Small cell lung cancer Hodgkin lymphoma Medulloblastoma ... lymphoma Langerhans cell histiocytosis Mixed lesions Breast cancer Testicular cancer Ovarian cancer Gastrointestinal cancers ... Bone-originating primary tumors such as osteosarcoma, chondrosarcoma, and Ewing sarcoma are rare; the most common bone tumor is ... Tumor cells may have paraneoplastic effects, such as via the secretion of Prostaglandin E, TGF-alpha, TGF-beta, TNF, and ...

https://en.wikipedia.org/wiki/Bone_metastasis

Carcinoids: most common, 44% Mesenchymal tumors: Leiomyosarcoma, peripheral nerve sheath and gastrointestinal stromal tumors, ... Benign tumors: Leiomyoma Lipoma Vascular and neuromuscular hamartoma Malignant tumors: ... tumors) in Meckel's diverticulum may cause bleeding, acute abdominal pain, gastrointestinal obstruction, perforation or ... Tumors e.g. carcinoma: direct spread of an adenocarcinoma arising in the diverticulum may lead to obstruction Lithiasis, stones ...

https://en.wikipedia.org/wiki/Meckel's_diverticulum

The goblet cell carcinoid (GCC) is a rare biphasic gastrointestinal tract tumour that consists of a neuroendocrine component ... December 2007). "Goblet cell carcinoid of the appendix: a specific type of carcinoma". Histopathology. 51 (6): 763-73. doi: ... Wikimedia Commons has media related to Goblet cell carcinoid. (Articles with short description, Short description matches ... Wikidata, Commons category link is on Wikidata, Gastrointestinal cancer). ...

https://en.wikipedia.org/wiki/Goblet_cell_carcinoid

Excess circulating serotonin is usually manufactured by EC-cell-originated carcinoid tumors in the small bowel or appendix. ... They reside alongside the epithelium lining the lumen of the digestive tract and play a crucial role in gastrointestinal ... Tumors are slow growing, but can metastasise to the liver if aggressive. They can also be present at other sites, particularly ... Carcinoid syndrome is a rare condition characterized by an abnormal increase in circulating biologically active hormones, ...

https://en.wikipedia.org/wiki/Enterochromaffin_cell

... cancer Gastrointestinal carcinoid tumor Gastrointestinal stromal tumor (GIST) Hepatocellular cancer Pancreatic cancer, islet ... Not all tumors or lumps are cancerous; benign tumors are not classified as being cancer because they do not spread to other ... surface epithelial-stromal tumor) Ovarian germ cell tumor Penile cancer Kidney cancer Renal cell carcinoma Renal pelvis and ... Benign tumors (which are not cancers) are usually named using -oma as a suffix with the organ name as the root. For example, a ...

https://en.wikipedia.org/wiki/List_of_cancer_types

There are many different kinds of endocrine tumors, some of which are listed below: Gastrointestinal ECLoma Midgut carcinoid ... Appendix carcinoid Hindgut carcinoid sometimes also referred to as Rectal carcinoid Pulmonary Typical bronchial carcinoid ... Atypical bronchial carcinoid Large cell neuroendocrine carcinoma Small cell lung cancer Endocrine pancreatic tumors Non- ... Endocrine oncology refers to a medical speciality dealing with hormone producing tumors, i.e. a combination of endocrinology ...

https://en.wikipedia.org/wiki/Endocrine_oncology

"Carcinoid Tumors and Syndrome". The Lecturio Medical Concept Library. Retrieved 5 July 2021. "Acromegaly". NIDDK. April 2012. ... gastrointestinal tract, and kidney". Proceedings of the National Academy of Sciences of the United States of America. 89 (1): ... is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid ... It is indicated for symptomatic treatment of carcinoid syndrome and acromegaly. It is also finding increased use in polycystic ...

https://en.wikipedia.org/wiki/Somatostatin

A carcinoid is a neuroendocrine tumor (NET) of the intestines. Incidence rates among carcinoids occur at about .15 per 100,000 ... Gastrointestinal stromal tumors are rare tumors with malignant potential. Primary lymphomas can occur in the appendix. Breast ... Carcinoid tumors are the most common tumors of the appendix. Other common forms are mucinous adenocarcinomas, adenocarcinoma ... Almost 3 out of 4 of these tumors are associated with the region at the end of the appendix, and tend to be diagnosed in the ...

https://en.wikipedia.org/wiki/Appendix_cancer

Miettinen M, Sobin, LH, Lasota J. Gastrointestinal stromal tumors of the stomach. A clinicopathologic, immunohistochemical, and ... Duodenal carcinoids: Imaging Features with Clinicopathologic Comparison. Radiology 2005;237:967-972 "Building a Bombproof ... and molecular characteristics of the relatively newly recognized gastrointestinal stromal tumors. Another special feature of ... The AFIP played a critical role in the standardization of pathologic diagnosis of tumors. This was mainly the result of the ...

https://en.wikipedia.org/wiki/Armed_Forces_Institute_of_Pathology

... and the management of symptoms caused by neuroendocrine tumors, particularly carcinoid tumors and VIPomas. In the United States ... The main side effects of lanreotide treatment are mild to moderate pain at the injection site and gastrointestinal disturbances ... is a medication used in the management of acromegaly and symptoms caused by neuroendocrine tumors, most notably carcinoid ... In the United Kingdom, it is also indicated in the treatment of thyrotrophic adenoma, a rare tumor of the pituitary gland which ...

https://en.wikipedia.org/wiki/Lanreotide

... with metastatic carcinoid tumors in adults profuse watery diarrhea associated with vasoactive intestinal peptide tumors ( ... Octreotide helps in management of the fistula by reducing gastrointestinal secretions and inhibiting gastrointestinal motility ... In a small clinical trial in eighteen pediatric subjects with intractable weight gain following therapy for ALL or brain tumors ... Octreotide is used for the treatment of growth hormone producing tumors (acromegaly and gigantism), when surgery is ...

https://en.wikipedia.org/wiki/Octreotide

The carcinoid syndrome occurs secondary to neuroendocrine tumors. These tumors occur mostly in the gut and less commonly in the ... Syndromes affecting the gastrointestinal tract). ... Carcinoid crisis is an extreme exacerbation of the carcinoid ... Carcinoid Neuroendocrine tumor Small intestine neuroendocrine tumor Kulchitsky cells Apudoma Pandit, Sudha; Annamaraju, Pavan; ... formerly known as carcinoid tumors). The syndrome is caused by neuroendocrine tumors most often found in the gut releasing ...

https://en.wikipedia.org/wiki/Carcinoid_syndrome

... gastrointestinal obstruction, lack of appetite, ascites, anemia, and cachexia.[citation needed] Other reported symptoms include ... and mesenteric carcinoid. In older patients DSRCT can resemble lymphoma, peritoneal mesothelioma, and peritoneal carcinomatosis ... The tumor is classified as a soft tissue sarcoma and a small round blue cell tumor. It most often occurs in male children. The ... "Orphanet: Desmoplastic small round cell tumor". www.orpha.net. Retrieved 17 November 2019. "Desmoplastic Small Round Cell Tumor ...

https://en.wikipedia.org/wiki/Desmoplastic_small-round-cell_tumor

In 1934 he obtained his habilitation with the thesis "Carcinoid und Carcinom", later serving as a professor in Danzig, Graz and ... he also made contributions in his research of various benign and malignant tumors, the transformation of lipids, the origin of ... according to studies on the human gastrointestinal tract. Über die Pathologie der vegetativen nervösen Peripherie und ihrer ...

https://en.wikipedia.org/wiki/Friedrich_Feyrter

... secondary to a large carcinoid tumor (not shown) that was completely obstructing the bronchus proximally. ... The impact of adverse effects of macrolides such as gastrointestinal symptoms, hepatotoxicity, and increased antimicrobial ... An airway obstruction can be caused by either an intraluminal mass such as a tumor or a foreign body. The presence of an airway ... Michael Filbin; Lisa M. Lee; Shaffer, Brian L. (2003). Blueprints pathophysiology II : pulmonary, gastrointestinal, and ...

https://en.wikipedia.org/wiki/Bronchiectasis

... at Who Named It Gastrointestinal Neuroendocrine Tumors Works by or about Otto Lubarsch at Internet Archive Media ... Among other contributions to medical knowledge, Lubarsch provided the first detailed description of carcinoid tumors. He ... In 1888 Lubarsch provided the first detailed description of carcinoid tumors during autopsies of two male "patients", however ... "Carninoid Tumors". The Oncologist. 13 (12): 1255-1269. doi:10.1634/theoncologist.2008-0207. PMC 2901509. PMID 19091780. ...

https://en.wikipedia.org/wiki/Otto_Lubarsch

Gastrointestinal and Pulmonary Carcinoid Tumors. The following organizations have issued clinical guidelines for the treatment ... NCCN guidelines recommend resection as the primary treatment for most carcinoid tumors of the gastrointestinal (GI) tract, lung ... Pulmonary neuroendocrine (carcinoid) tumors: European Neuroendocrine Tumor Society expert consensus and recommendations for ... uses only mitotic count for bronchial and thymic tumors for determining tumor grade, as follows [8] :. * Low-grade tumors: , 10 ...

https://emedicine.medscape.com/article/2500010-overview

https://reference.medscape.com/article/2500010-overview

A Gastrointestinal Carcinoid Tumor is cancer that forms in the lining of the gastrointestinal tract. Click to read more. ... Treatment Options for Gastrointestinal Carcinoid Tumors. *Carcinoid Tumors in the Stomach. *Carcinoid Tumors in the Small ... The metastatic tumor is the same type of tumor as the primary tumor. For example, if a gastrointestinal (GI) carcinoid tumor ... Stages of Gastrointestinal Carcinoid Tumors. KEY POINTS. *After a gastrointestinal carcinoid tumor has been diagnosed, tests ...

https://myacare.com/procedure/treatment-of-gastrointestinal-carcinoid-tumors

title = "Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome",. abstract = "Gastrointestinal (GI) carcinoids are ... Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome. / Van Gompel, Jamie J.; Sippel, Rebecca S.; Warner, Tom F. et ... Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome. Jamie J. Van Gompel, Rebecca S. Sippel, Tom F. Warner, Herbert ... Gastrointestinal Carcinoid Tumors : Factors that Predict Outcome. In: World Journal of Surgery. 2004 ; Vol. 28, No. 4. pp. 387- ...

https://mayoclinic.elsevierpure.com/en/publications/gastrointestinal-carcinoid-tumors-factors-that-predict-outcome

Carcinoid tumors of the extrahepatic bile duct are exceedingly rare and account for between 0.1% and 2% of all gastrointestinal ... Carcinoid tumors of the extrahepatic bile duct are exceedingly rare and account for between 0.1% and 2% of all gastrointestinal ... ArticleTitleCarcinoid tumor of the hepatic duct presenting as a Klastkin tumor in an aldolescent and review of World literature ... DL Jutte PH Bell IM Penn J Powers J Kolijivadi (1986) ArticleTitleCarcinoid tumor of the biliary system Dig Dis Sci 32 763-9 ...

https://link.springer.com/article/10.1007/s00595-005-3174-5?error=cookies_not_supported&code=18dc74d6-a38c-4cf9-a3be-bd14a52065fd

Pediatric Gastrointestinal Neuroendocrine Tumors Treatment. Gastrointestinal Neuroendocrine (Carcinoid) Tumors of the Appendix ... Carcinoid) Tumors. Clinical Presentation. Extra-appendiceal neuroendocrine (carcinoid) tumors are rare. Most are sporadic but ... This summary was renamed from Childhood Gastrointestinal Carcinoid Tumors Treatment.. This summary is written and maintained by ... For more information about treatment options for patients with malignant carcinoid tumors, see Gastrointestinal Neuroendocrine ...

https://www.oncolink.org/healthcare-professionals/nci/pqid-cdr0000799718

Most gastrointestinal carcinoid tumors tend not to respond to chemotherapy agents, showing 10 to 20% response rates that are ... Parathyroid tumors Thymus and mediastinal carcinoid tumors Pulmonary neuroendocrine tumors bronchus pulmonary carcinoid tumors ... "Carcinoid Tumors and the Carcinoid Syndrome: Whats New in the Therapeutic Pipeline". Carcinoid Symposium 2002. The Carcinoid ... Small intestinal neuroendocrine tumors were first distinguished from other tumors in 1907. They were named carcinoid tumors ...

https://en.wikipedia.org/wiki/Neuroendocrine_tumor

Carcinoid tumors are rare cancers that usually start in the lining of the digestive tract and lungs, but can occur in other ... Please see our page on Gastrointestinal Carcinoid Tumors.. Support Cancer Research Your gift helps the American Association for ... November is Carcinoid Cancer Awareness Month. JOIN WITH THE AACR TO FIND BETTER WAYS TO PREVENT AND TREAT CARCINOID CANCER. ... Carcinoid tumors are rare, slow-growing cancers that usually start in the lining of the digestive tract and lungs, but can also ...

https://www.aacr.org/patients-caregivers/awareness-months/carcinoid-cancer-awareness-month/

Gastrointestinal Carcinoid Tumors Adult Genetics of Breast and Gynecologic Cancers (PDQ®)-Health Professional Version ...

https://www.vicc.org/cancer-info?name=breast-cancer

Carcinoid Tumor : Adenocarcinoid type. Home "> Gastrointestinal "> Appendix "> Well-differentiated Neuroendocrine Tumor "> ... Carcinoid Tumor : Adenocarcinoid type. High Quality Pathology Images of Gastrointestinal, Appendix, Well-differentiated ... Some carcinoid tumors display predominantly glandular architecture and have been referred to as adenocarcinoids. They should ...

https://www.webpathology.com/image.asp?n=20&Case=216

Gastrointestinal Cancers. Information Patients and the Public (13 links). Gastrointestinal Carcinoid Tumors Treatment ... BACKGROUND: Gastrointestinal stromal tumors (GISTs) account for less than 1% of all gastrointestinal tumors. The biological ... Gastrointestinal Carcinoid Tumors Treatment National Cancer Institute. PDQ summaries are written and frequently updated by ... tumor localization, the diameter of the tumor, tumor grade, invasion, surgical margin, and stage of the tumor was performed.. ...

http://www.cancerindex.org/clinks2ka.htm

Carcinoid tumors: Carcinoid tumors are the most common appendix cancers, making up about half of those diagnosed. They are ... They are a type of gastrointestinal neuroendocrine tumor (NET). * Carcinomas. Carcinomas of the appendix include: * Mucinous ... also called adenocarcinoid tumors): These are less common tumors, which, despite the name, are not carcinoid tumors or NETs. ... The two main types of appendix cancer are called carcinoid tumors and carcinomas. ...

https://www.mskcc.org/cancer-care/types/appendiceal/diagnosis/types

Gastrointestinal carcinoid tumor. *Depending on the stage of cancer and whether it is in the upper (duodenal) or lower (jejunum ... Patients with existing gastrointestinal disorders, such as Crohns disease or celiac disease, are at a higher risk of ... Treatment methods depend on the stage, location, and size of the tumor. Some abnormalities can be removed surgically; others ... Compared to other malignancies usually found in the gastrointestinal tract-gastric (stomach) cancer and colorectal cancer among ...

https://www.knowcancer.com/cancer-types/small-intestine-cancer/

A cumulative analysis of all types of carcinoid tumors in the SEER group indicates that in 4 … ... Carcinoids appear to have increased in incidence in the past 20 years. In part, this may be due to different surgical rules of ... Results: The most frequent sites for carcinoids were the gastrointestinal (GI) tract (73.7%) and the bronchopulmonary system ( ... An analysis of 8305 cases of carcinoid tumors Cancer. 1997 Feb 15;79(4):813-29. doi: 10.1002/(sici)1097-0142(19970215)79:4,813 ...

https://pubmed.ncbi.nlm.nih.gov/9024720/?dopt=Abstract

These tumors start from special hormone-making cells in the intestine.. *Gastrointestinal stromal tumors (GISTs). These tumors ... Carcinoid tumors. ... Tumor markers. Blood tests for these tumor markers can ... These tumors can start in blood vessels, muscle layers, or other connective tissues in the wall of the colon and rectum. ... Endorectal MRI. MRI scans can be used in patients with rectal cancers to see if the tumor has spread into nearby structures. ...

https://www.uchealth.org/diseases-conditions/colon-cancer/

Requiem for the term carcinoid tumour in the gastrointestinal tract? Can J Gastroenterol. 2008;22:357-358. [PubMed] [DOI] [ ... NETs: Neuroendocrine tumors; T1: Tumor , 2 cm; T2: Tumor ≥ 2 cm but , 3 cm; T3: Tumor ≥ 3 cm; N0: No lymph node metastases; N1 ... Genetic alterations in goblet cell carcinoids of the vermiform appendix and comparison with gastrointestinal carcinoid tumors. ... Carcinoid tumour of the appendix. Br J Surg. 2003;90:1317-1322. [PubMed] [DOI] [Cited in This Article: ] ...

https://wjgnet.com/1948-5204/full/v2/i4/192.htm

About 66% of all carcinoid tumors develop in the gastrointestinal tract. If the tumor can be surgically removed and has not ... The location of origin of carcinoid tumors is divided into three categories:. *Foregut Carcinoid Tumors - These tumors ... most people diagnosed with a carcinoid tumor are in their 50s.. Carcinoid tumors are slow-growing tumors and most do not cause ... and can cause carcinoid syndrome. Most carcinoid tumors are now known to be slow growing malignant tumors that have their own ...

https://www.medifocus.com/landing.php?gid=GS019&a=a&assoc=digest&keyword=266--1

Gastrointestinal Carcinoid Tumours Carcinoid Tumors MKI67 Cancer of the Pancreas Pancreatic Cancer ... The Authors report their experiences on the treatment of 13 consecutive cases of gastro-intestinal carcinoid tumors observed ... Chemotherapy with 5-fluorouracil and streptozotocin in carcinoid tumors of gastrointestinal origin: experiences with 13 ... Neuroendocrine tumors (NETs) of the gastrointestinal tract have a propensity for hepatic metastases. Surgical resection for ...

http://www.cancerindex.org/Streptozocin

Small intestine cancer comes in five types: adenocarcinomas, sarcoma, carcinoid tumors, gastrointestinal stomach tumors (GISTs ...

https://medicalmalpracticehelp.com/misdiagnosis/cancer/small-intestine-cancer-lawyer/

The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by ... A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery ... Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid ... carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome. BMC Cancer. 2019 Mar 28; ...

https://connects.catalyst.harvard.edu/Profiles/display/Concept/Malignant%20Carcinoid%20Syndrome

The third case comprised a mucinous adenocarcinoma and carcinoid tumor in the large gut.Keywords: collision tumor, histology, ... There were two cases of collision tumors involving the stomach, one of which was a combination of adenocarcinoma and low-grade ... Here we present three rare cases of collision tumors involving the stomach and transverse colon. ... A collision tumor is one where histology shows the presence of two distinct primaries involving the same organ without ...

https://www.dovepress.com/collision-tumors-in-the-gastrointestinal-tract-a-rare-case-series-peer-reviewed-fulltext-article-IMCRJ

at 550 × 508 in Gastrointestinal Neuroendocrine Tumors and The Carcinoid Syndrome. ← Previous Next → Figure 52. ...

https://www.endotext.org/chapter/gastrointestinal-neuroendocrine-tumors-and-the-carcinoid-syndrome/figure52/

Carcinoid tumors are most commonly located in the gastrointestinal tract (midgut carcinoid), bronchus (foregut carcinoid), and ... Carcinoid tumors of midgut origin usually present as classic carcinoid syndrome, whereas the syndrome is rare in tumors of ... Carcinoid syndrome is a rare endocrine disorder related to the effects of vasoactive substances produced by carcinoid tumors, ... Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. ...

https://karger.com/crd/article/146/1/65/97177/Carcinoid-Heart-Disease-Pathophysiology-Pathology

Hoxc6 is overexpressed in gastrointestinal carcinoids and interacts with JunD to regulate tumor growth. Gastroenterology 2008; ... Cables1 is a tumor suppressor gene that regulates intestinal tumor progression in Apc(Min) mice. Cancer Biol Ther 2013; 14:672- ... The Enigma of Carcinoids. Gastroenterology 2015; 149:14-5. PubMed * Richter JM, Campbell EJ, Chung DC. Interval colorectal ... Director, Hi-Risk Gastrointestinal Cancer Clinic, Massachusetts General Hospital. DF/HCC PROGRAM AFFILIATION *Cancer Genetics ...

https://www.dfhcc.harvard.edu/insider/member-detail/member/daniel-c-chung-md/

These tumors usually arise in the gastrointestinal tract and from there may spread (metastasize) to the liver. Carcinoid tumors ... and abnormal laboratory chemical findings caused by a carcinoid tumor. A carcinoid tumor is an old word for a neuroendocrine ... Only about 10 percent of the people with carcinoid tumors will develop the carcinoid syndrome. Major symptoms of this syndrome ... such as primary tumor location and extent of the primary tumor (stage); whether the tumor is malignant and whether it has ...

https://rarediseases.org/rare-diseases/pancreatic-neuroendocrine-neoplasms-pnens/

Pulmonary Carcinoids and Low-Grade Gastrointestinal Neuroendocrine Tumors Show Common MicroRNA Expression Profiles, Different ...

https://karger.com/mpp/article/32/4-5/297/863208/Biomarker-Phenotypes-in-Heart-Failure-with

Carcinoid syndrome is associated with neuroendocrine tumors of the lung or gastrointestinal tract origin; diarrhea is among the ... The syndrome affects ,1% of the US population, and in approximately 40% of the patients with carcinoid syndrome diarrhea, ... Budget impact of telotristat ethyl in the treatment of patients with uncontrolled carcinoid syndrome.] ... for the treatment of patients with carcinoid syndrome diarrhea that is not controlled with a somatostatin analog alone. ...

https://ahdbonline.com/issues/2017/december-2017-vol-10-no-9/2523-amcp-nexus-2017-highlights

This years Clinical Cancer Advances report describes emerging treatments for thyroid cancer, uterine cancer, desmoid tumor, ... Midgut neuroendocrine tumors (NETs) are a rare type of gastrointestinal tract NET, which were previously called carcinoid ... Treating desmoid tumors with sorafenib. A desmoid tumor, also called deep fibromatosis, is a rare type of soft-tissue sarcoma ... Desmoid tumors are challenging to treat and can come back after treatment unexpectedly. And, some of these tumors may shrink or ...

https://www.cancer.net/blog/2019-01/progress-treating-rare-cancers-2019-advance-year

... carcinoid tumors and gastrointestinal stromal tumors (GISTs). Learn more about our colorectal cancer services. ... We are equipped to treat non-small cell lung cancers (NSCLCs), small cell lung cancers, lung carcinoid tumors and very rare ...

https://www.bjc.org/services/chemotherapy-and-medical-oncology

Gastrointestinal Stromal Tumors, Carcinoid Tumor, Carcinoma, Transitional Cell, Carcinoma, Adenoid Cystic, Adenocarcinoma of ... A Study of CPI-0209 in Patients With Advanced Solid Tumors and Lymphomas. Conditions: Lymphoma, Neoplasms, Lymphoma, Large B- ... Nivolumab and Ipilimumab in Treating Patients With Rare Tumors. Conditions: Carcinoma, Neoplasms, Carcinoma, Squamous Cell, ... Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of INCB099280 in Participants With Advanced Solid Tumors. ...

https://www.mesothelioma.com/states/michigan/treatment/

A gastrointestinal carcinoid tumor is cancer that forms in the lining of the gastrointestinal tract. (myacare.com)
The gastrointestinal (GI) tract is part of the body's digestive system . (myacare.com)
Gastrointestinal (GI) carcinoids are neuroendocrine tumors originating in multiple locations throughout the GI tract. (elsevierpure.com)
Additionally, the WHO scheme recognizes mixed tumors with both neuroendocrine and epithelial carcinoma features, such as goblet cell cancer, a rare gastrointestinal tract tumor. (wikipedia.org)
The WHO grading from 2022 endorses a three-tiered grading system for most NETs, in particular NETs of the gastrointestinal or pancreaticobiliary tract, as well as NETs of the upper aerodigestive tract and the salivary glands. (wikipedia.org)
Tumor necrosis, although recognized as a factor associated with a potentially worse prognosis, is not included in the grading of NETs of the gastrointestinal or pancreaticobiliary tract. (wikipedia.org)
However, the absence or presence of tumor necrosis is a component of the grading of NETs of many other origins, such as the upper aerodigestive tract, the lung and the thymus. (wikipedia.org)
NETs include certain tumors of the gastrointestinal tract and of the pancreatic islet cells, certain thymus and lung tumors, and medullary carcinoma of the parafollicular cells of the thyroid. (wikipedia.org)
Carcinoid tumors are rare, slow-growing cancers that usually start in the lining of the digestive tract and lungs, but can also occur in other areas, including the testes and ovaries. (aacr.org)
Compared to other malignancies usually found in the gastrointestinal tract-gastric (stomach) cancer and colorectal cancer among them-small intestine cancer is decidedly rare. (knowcancer.com)
About 66% of all carcinoid tumors develop in the gastrointestinal tract. (medifocus.com)
The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. (harvard.edu)
The goals of the laboratory are: (1) to define the molecular pathogenesis of endocrine tumors of the GI tract. (harvard.edu)
Midgut neuroendocrine tumors (NETs) are a rare type of gastrointestinal tract NET, which were previously called carcinoid tumors. (cancer.net)
Normally, the small intestine and colon absorb 99% of fluid resulting from oral intake and gastrointestinal (GI) tract secretions-a total fluid load of about 9 of 10 L daily. (merckmanuals.com)
It is rare, commonly occurring in the head and neck region, followed by the gastrointestinal tract. (scielo.org.za)
Primary plasmacytoma of the gastrointestinal tract is even rarer, occurring in approximately 10% of cases. (scielo.org.za)
2 All the segments of the gastrointestinal tract may be involved. (scielo.org.za)
Approximately 74% of all carcinoid tumors arise from the gastrointestinal (GI) tract and the liver is a common site for metastases [ 1 ]. (biomedcentral.com)
They are rare tumors and occur most commonly in the gastrointestinal tract, followed by the pulmonary system. (bvsalud.org)
Gastroenteritis is a nonspecific term for various pathologic states of the gastrointestinal tract. (medscape.com)
The small intestine is the prime absorptive surface of the gastrointestinal tract. (medscape.com)

Pancreatic Neuroendocrine Tumors (Islet Cell Tumors) Treatment. (myacare.com)
In 2020, Etay Ziv, MD, PhD, of Memorial Sloan Kettering Cancer Center, was awarded a grant to study when and how high-grade pancreatic neuroendocrine tumors (pNETs) arise in the course of the disease and how to identify subclones selected for therapy. (aacr.org)

Risk factors for carcinoid cancers include having a family history of multiple endocrine neoplasia type 1 (MEN1) syndrome or neurofibromatosis type 1 (NF1) syndrome, and having certain conditions that affect the stomach's ability to make stomach acid, such as atrophic gastritis, pernicious anemia, or Zollinger-Ellison syndrome. (aacr.org)
The organization's mission is to fund research to discover cures and more effective treatments for carcinoid, pancreatic, and related neuroendocrine cancers. (aacr.org)
Carcinoid tumors are the most common appendix cancers, making up about half of those diagnosed. (mskcc.org)
We treat the full range of colon and rectum cancers, including adenocarcinomas, carcinoid tumors and gastrointestinal stromal tumors (GISTs). (bjc.org)
We are equipped to treat non-small cell lung cancers (NSCLCs), small cell lung cancers, lung carcinoid tumors and very rare types. (bjc.org)
Adenocarcinoma, lymphoma, sarcoma, and carcinoid tumors account for the majority of small intestine cancers. (surgeryencyclopedia.com)
According to the National Cancer Institute, adenocarcinoma, lymphoma, sarcoma, and carcinoid tumors account for the majority of small intestine cancers which, as a whole, account for only 1-2% of all gastrointestinal cancers diagnosed in the United States. (surgeryencyclopedia.com)
Blase Polite, MD, has expertise in the treatment of gastrointestinal (GI) malignancies, with a particular focus on colon, rectal, and anal cancers, and neuroendocrine (carcinoid) tumors. (uchicagomedicine.org)

New insights emerged last decade that enriched our knowledge regarding the biological behavior of appendiceal neuroendocrine tumors (NETs), which range from totally benign tumors less than 1cm to goblet cell carcinomas which behave similarly to colorectal adenocarcinoma. (wjgnet.com)
There were two cases of collision tumors involving the stomach, one of which was a combination of adenocarcinoma and low-grade non-Hodgkin's (mucosa-associated lymphoid tissue) lymphoma, and the other showed the presence of non-Hodgkin's lymphoma involving the entire stomach wall along with adenocarcinoma infiltrating the muscle layer. (dovepress.com)
The third case comprised a mucinous adenocarcinoma and carcinoid tumor in the large gut. (dovepress.com)

Neuroendocrine tumors (NETs) are neoplasms that arise from cells of the endocrine (hormonal) and nervous systems. (wikipedia.org)
Neuroendocrine carcinomas are poorly differentiated high-grade neuroendocrine neoplasms and a designation of tumor grade is therefore redundant. (wikipedia.org)
Lung and thymic neuroendocrine neoplasms are classified in a similar manner, including typical and atypical carcinoids, small cell and large cell neuroendocrine carincomas. (wikipedia.org)
Nonfunctioning neuroendocrine neoplasms can still cause symptoms relating to tumor size and location such as obstruction or internal bleeding. (rarediseases.org)
1 Neoplasms such as benign lipomas, 2 adenocarcinomas, 2,3 gastrointestinal stromal tumor, 4 and signet-ring cell adenocarcinomas are also found 5 within MD on rare occasion. (radiologytoday.net)

Carcinoid syndrome may occur if the tumor spreads to the liver or other parts of the body. (myacare.com)
If the tumor has spread to the liver and the liver enzymes cannot destroy the extra hormones made by the tumor, high amounts of these hormones may remain in the body and cause carcinoid syndrome. (myacare.com)
Over the years it became clear that carcinoid tumors can be quite aggressive, can metastasize, and can cause carcinoid syndrome . (medifocus.com)
Symptoms are often associated with the site of tumor origin and reflect the tumor obstructing organs involved in normal body function but may be less specific if related to carcinoid syndrome. (medifocus.com)
Carcinoid syndrome describes a combination of symptoms that result from hormones or hormone-like substances, (e.g., serotonin, gastrin, ACTH) that are produced by some carcinoid tumors. (medifocus.com)
Malignant Carcinoid Syndrome" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Malignant Carcinoid Syndrome" by people in Harvard Catalyst Profiles by year, and whether "Malignant Carcinoid Syndrome" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Malignant Carcinoid Syndrome" by people in Profiles. (harvard.edu)
Assessment of change in quality of life, carcinoid syndrome symptoms and healthcare resource utilization in patients with carcinoid syndrome. (harvard.edu)
Impact of carcinoid syndrome symptoms and long-term use of somatostatin analogs on quality of life in patients with carcinoid syndrome: A survey study. (harvard.edu)
Changes in Weight Associated With Telotristat Ethyl in the Treatment of Carcinoid Syndrome. (harvard.edu)
Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial. (harvard.edu)
Understanding the Patient Experience with Carcinoid Syndrome: Exit Interviews from a Randomized, Placebo-controlled Study of Telotristat Ethyl. (harvard.edu)
Cost reduction from resolution/improvement of carcinoid syndrome symptoms following treatment with above-standard dose of octreotide LAR. (harvard.edu)
Advances in the management of patients with carcinoid syndrome. (harvard.edu)
Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome. (harvard.edu)
Published May 16, 2013 at 550 × 508 in Gastrointestinal Neuroendocrine Tumors and The Carcinoid Syndrome . (endotext.org)
Treatment focuses on control of the underlying carcinoid syndrome, targeting subsequent valvular heart disease and managing consequent heart failure. (karger.com)
Carcinoid syndrome - Patients with foregut carcinoid tumors may suffer from carcinoid syndrome, which classically manifests with gastrointestinal complaints. (logicalimages.com)
Carcinoid syndrome from a tumor of Meckelâ€™s diverticulum. (radiologytoday.net)
Functional gastrointestinal disorders such as irritable bowel syndrome , functional abdominal bloating and distention, functional constipation, and functional dyspepsia may cause problems with gas symptoms. (fatiguetalk.com)
Findings range from no tumor-related symptoms (most carcinoid tumors) to full symptoms of carcinoid syndrome (primarily in adults). (medscape.com)
The diagnosis of concurrent Cushing syndrome and carcinoid syndrome can be challenging, as it is rare. (bvsalud.org)
CONCLUSIONS Incidental hypertension in children is not common and mandates further investigation and clinical work-up to look for endocrinopathies such as Cushing syndrome and carcinoid syndrome. (bvsalud.org)
Malignant carcinoid syndrome occurs in fewer than 10% of patients with a carcinoid tumor. (medscape.com)
Carcinoids do not produce the malignant carcinoid syndrome until they are no longer confined to the small bowel or mesentery, perhaps because the liver breaks down the secretory products of tumors restricted to those locations. (medscape.com)
If a patient is thought to have carcinoid syndrome, blood and urine tests must be performed to determine levels of bioactive substances secreted by carcinoid tumors. (medscape.com)

The patients were grouped into three categories based on the origin of the carcinoid tumor: foregut, midgut, hindgut. (elsevierpure.com)
Patients with foregut or midgut lesions had lower 5-year disease-free survivals than those with hindgut tumors. (elsevierpure.com)
Despite the larger tumor size and the higher incidence of liver metastases, patients with foregut carcinoids appear to have the same prognosis as those with midgut carcinoids. (elsevierpure.com)
As opposed to foregut carcinoid tumors, patients with midgut tumors typically demonstrate a more cyanotic flushing. (logicalimages.com)
Typically, 90% of carcinoid tumors originate from the distal ileum or appendix (the embryologic midgut. (medscape.com)

A desmoid tumor, also called deep fibromatosis, is a rare type of soft-tissue sarcoma that develops in the connective tissues that support and connect the body. (cancer.net)

They most commonly occur in the intestine, where they are often called carcinoid tumors, but they are also found in the pancreas, lung, and the rest of the body. (wikipedia.org)
There are rare reported cases of carcinoid tumor presenting in the pancreas as gastrinoma or insulinoma and are associated with multiple endocrine neoplasia type 1 (MEN1). (bvsalud.org)
She was diagnosed with incidental carcinoid tumor in the pancreas based on hypertension and typical stigmata. (bvsalud.org)

A cumulative analysis of all types of carcinoid tumors in the SEER group indicates that in 45.3% metastases are already evident at the time of diagnosis. (nih.gov)

The optimal management of patients with carcinoid tumors involves a multidisciplinary team of health care providers including an oncologist, gastroenterologist, surgeon, radiologist and nuclear medicine specialist. (medifocus.com)

Carcinoid tumors in the small intestine (duodenum, jejunum, and ileum), colon, and rectum sometimes cause signs or symptoms as they grow or because of the hormones they make. (myacare.com)
These tumors can start in blood vessels, muscle layers, or other connective tissues in the wall of the colon and rectum. (uchealth.org)
Hindgut Carcinoid Tumors - These tumors originate in the large intestines, specifically in the transverse colon, descending colon, and rectum. (medifocus.com)

Perforated Meckelâ€™s diverticulum presenting as a gastrointestinal stromal tumor: A case report. (radiologytoday.net)

Approximately 3,000 new cases of lung carcinoid tumors are diagnosed in the United States each year. (medifocus.com)

In adults, it has been accepted practice to remove the entire right colon in patients with large neuroendocrine tumors of the appendix (>2 cm in diameter) or with tumors that have spread to the lymph nodes. (oncolink.org)
These tumors start from special cells in the wall of the colon called the interstitial cells of Cajal. (uchealth.org)
Here we present three rare cases of collision tumors involving the stomach and transverse colon. (dovepress.com)
Dr. Polite has initiated several clinical research trials aimed at advancing our treatment of colon and rectal cancer at all stages including for individuals whose tumor has grown despite standard treatments. (uchicagomedicine.org)

Carcinoid tumors were initially identified in 1888 and were thought to clinically and histologically (cellular appearance under a microscope) resemble carcinoma cells (highly malignant cancer cells) but behave in a more benign fashion than true cancer cells. (medifocus.com)

Moreover, the size of the primary tumor and the presence of liver metastases were not independent predictors of survival. (elsevierpure.com)
Placing a given tumor into one of these categories depends on well-defined histological features: size, lymphovascular invasion, mitotic count, Ki-67 labelling index, invasion of adjacent organs, presence of metastases and whether they produce hormones. (wikipedia.org)
Signs and symptoms of carcinoid tumors vary greatly and depend on the tumor location and size as well as on the presence of metastases. (medscape.com)
In particular, these metastases make a malignant tumor on the life-threatening danger. (drsymptoms.com)
and asthma attacks-caused by vasoactive hormones secreted by metastases from carcinoid tumors. (medscape.com)
Imaging studies also must be performed to detect the sites of either primary tumors or metastases. (medscape.com)

We herein present what we believe is only the 47th reported case of a primary carcinoid tumor occurring in the extrahepatic bile ducts. (springer.com)
No recurrences were observed among the patients with appendiceal primary tumors treated with appendectomy alone, which supports resection of the appendix without hemicolectomy as the procedure of choice. (oncolink.org)
Level of evidence C1] Primary re-excision was not recommended for completely excised tumors smaller than 2 cm except for microscopic/macroscopic residual tumor on the margins of the appendix, in which case cecum resection and pericecal node biopsy was recommended. (oncolink.org)
Decisions about tumors larger than 2 cm were made at the discretion of the primary physicians. (oncolink.org)
Additionally, performance status (PS) and resection of the primary tumor were observed to influence mOS. (cancerindex.org)
Surgical treatment of carcinoid tumors is generally based on the size and extent of the primary lesion. (radiologytoday.net)
Primary hepatic carcinoid tumor (PHCT) is very rare and difficult to diagnose before biopsy or operation. (biomedcentral.com)

The name was chosen to separate these tumors from ordinary malignancies (carcinomas), but by the 1950s, the fact that carcinoids could be malignant was obvious, thanks to Erspamer and Asero (1952), who identified serotonin production by carcinoid tumors. (medscape.com)

ZS E Rassi RM Mohsine F Berger P Thierry CC-M Partensky (2004) ArticleTitle Endocrine tumors of the extrahepatic bile duct. (springer.com)

The two main types of appendix cancer are called carcinoid tumors and carcinomas. (mskcc.org)

Carcinoid cancer often does not produce symptoms in the early stages, and is often diagnosed inadvertently during an X-ray for an unrelated reason. (aacr.org)
Carcinoid cancer is more common in women than men. (aacr.org)
What Is the AACR Doing in The Area of carcinoid cancer research? (aacr.org)
The Neuroendocrine Tumor Research Foundation (NETRF) - formerly the Caring for Carcinoid Foundation - has been a partner of the American Association for Cancer Research (AACR) since 2011. (aacr.org)
Patients with existing gastrointestinal disorders, such as Crohn's disease or celiac disease, are at a higher risk of developing small intestine cancer. (knowcancer.com)
Depending on the stage of cancer and whether it is in the upper (duodenal) or lower (jejunum and ileum) part of the intestine, the tumor may be removed surgically. (knowcancer.com)
The authors evaluated 5468 cases identified by the Surveillance, Epidemiology, and End Results (SEER) program of the National Cancer Institute (NCI) from 1973 to 1991 together with 2837 carcinoid cases previously registered by 2 earlier NCI programs. (nih.gov)
Carcinoid tumors share some properties with other cancer cells such as uncontrolled, overproduction of the cells that results in tumor formation and malignant potential. (medifocus.com)
Circulating tumour cells as a biomarker for diagnosis and staging in pancreatic cancer. (uclahealth.org)
When the tumor is large, removal of the small intestine segment containing the cancer is usually indicated. (surgeryencyclopedia.com)
Bethany Cancer Center, located in San Fernando, La Union, Philippines offers patients Pancreatic Islet Cell Tumor Treatment procedures among its total of 107 available procedures, across 1 different specialties. (mymeditravel.com)
Currently, there's no pricing information for Pancreatic Islet Cell Tumor Treatment procedures at Bethany Cancer Center, as all prices are available on request only. (mymeditravel.com)
Jose R. Reyes Memorial Medical Center - POCC Cancer Institute, located in Manila, Metro Manila, Philippines offers patients Pancreatic Islet Cell Tumor Treatment procedures among its total of 107 available procedures, across 1 different specialties. (mymeditravel.com)
Currently, there's no pricing information for Pancreatic Islet Cell Tumor Treatment procedures at Jose R. Reyes Memorial Medical Center - POCC Cancer Institute, as all prices are available on request only. (mymeditravel.com)
Gastrointestinal oncology cancer is the most common cancer in the world. (gastroconferences.com)
It refers to malignant conditions of gastrointestinal GI Cancer is the most common form of cancer. (gastroconferences.com)
The most dangerous feature of cancer cells, however, is to invade adjacent tissue, and spread in the body to form secondary tumors at distant sites. (drsymptoms.com)
The treatment for colorectal cancer is devised after considering numerous factors like the tumor location, the disease stage, the patient's age, and the overall condition of the patient. (hcgmanavatacancer.org)

The World Health Organization (WHO) and the European Neuroendocrine Tumor Society (ENETS) both incorporate mitotic count and Ki-67 proliferation for the classification of gastroenteropancreatic NETs (GEP-NETs). (medscape.com)
The various kinds of cells that can give rise to NETs are present in endocrine glands and are also diffusely distributed throughout the body, most commonly Kulchitsky cells or similar enterochromaffin-like cells, that are relatively more common in the gastrointestinal and pulmonary systems. (wikipedia.org)
These are less common tumors, which, despite the name, are not carcinoid tumors or NETs. (mskcc.org)
Thus, the term "carcinoid" was replaced by the term "gastroenteropancreatic neuroendocrine tumors, GEP-NETs"[ 2 ]. (wjgnet.com)
Neuroendocrine tumors (NETs) are believed to be relatively rare and to follow a generally indolent course. (cancerindex.org)
All NETs are considered malignant tumors. (cancer.net)

Between 1992 and 2000 a total of 70 patients with GI carcinoid tumors underwent surgical resection at our institution. (elsevierpure.com)
There was no tumor embolus in the vessels and the resection line was free from tumor invasion. (biomedcentral.com)

Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
We undertook a more thorough investigation to rule out the possibility that the liver tumor was a metastatic carcinoid. (biomedcentral.com)

Gastrointestinal carcinoid tumors form from a certain type of neuroendocrine cell (a type of cell that is like a nerve cell and a hormone -making cell). (myacare.com)
These tumors are a type of neuroendocrine tumor - growths that begin in the cells of the nervous and hormonal systems. (aacr.org)

A section of a rare lymph node metastasis from adenocarcinoid tumor (250 X). Image courtesy of Professor Pantaleo Bufo, University of Foggia, Italy. (medscape.com)

However, carcinoid tumor cells are distinguished from most other types of tumors in that they secrete various hormone-like substances (e.g., serotonin, noradrenalin, histamines) which may cause symptoms throughout the body rather than symptoms localized to the organ where the tumor originates. (medifocus.com)
Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. (harvard.edu)
The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. (karger.com)
Carcinoid tumors are neuroendocrine origin neoplasm and may produce serotonin or other functional peptide hormones. (biomedcentral.com)

Previously, Ali Azhdarinia, PhD, University of Texas Health Science Center at House, was awarded a grant to support his work on image-guided drug delivery using positron emission tomography (PET) to improve chemotherapy for neuroendocrine tumors. (aacr.org)
The patient demographics, tumor characteristics, context of STZ chemotherapy, and patient outcome were collected and assessed. (cancerindex.org)

Treatment methods depend on the stage, location, and size of the tumor. (knowcancer.com)
The prognosis (outlook or chance of recovery) for patients with carcinoid tumors is based primarily on size of the tumor and the degree to which it has spread and invaded other tissues in the body. (medifocus.com)

The tumour was transmural and the lymph nodes were free from metastasis. (scielo.org.za)
Carcinoid tumors have high potential for metastasis. (medscape.com)
Background: Tumor size and lymphovascular invasion are known high-risk factors for lymph node and distant metastasis in patients with rectal carcinoid tumors. (elsevierpure.com)

Some tumors, especially tumors of the stomach or appendix, may not cause signs or symptoms. (myacare.com)

Study results suggest that appendectomy alone is sufficient treatment for pediatric appendiceal neuroendocrine tumors regardless of size, position, histology, or nodal or mesenteric involvement and that right hemicolectomy is unnecessary in children. (oncolink.org)
The Italian Tumori Rari in Etá Pediatrica project performed a prospective registry study that evaluated 113 patients with appendiceal neuroendocrine tumors. (oncolink.org)
Thirty-five patients had extension of tumor beyond the appendiceal wall. (oncolink.org)
The study concluded that appendectomy alone should be considered curative for most cases of appendiceal neuroendocrine tumors. (oncolink.org)
A systematic review and meta-analysis of 38 studies of appendiceal neuroendocrine tumors identified 958 cases with a mean age at presentation of 11.6 years. (oncolink.org)
However, the continuous knowledge which was added by studying these tumors for nearly a century strengthen the notion that the above term was inaccurate or inadequate to describe several parameters of this heterogeneous group of gastrointestinal tumors (including the appendiceal one). (wjgnet.com)
[ 9 ] ) Carcinoid tumors represent 90% of appendiceal tumors. (medscape.com)

The final pathologic diagnosis was well-differentiated carcinoid tumor of a malignant nature. (springer.com)
The age at diagnosis varies somewhat among specific tumor locations but typically, most people diagnosed with a carcinoid tumor are in their 50s. (medifocus.com)
Due to their vague and intermittent symptoms, diagnosis of carcinoid tumors may be delayed, especially in children, in whom the tumor is rare and the diagnosis is unexpected. (medscape.com)
Laboratory diagnosis of carcinoid tumors depends on the identification of the characteristic biomarkers of the disease. (medscape.com)

Most carcinoid tumors are now known to be slow growing malignant tumors that have their own specific biological and clinical characteristics. (medifocus.com)

The World Health Organization (WHO) classification scheme places neuroendocrine tumors into three main categories, which emphasize the tumor grade rather than the anatomical origin: well-differentiated neuroendocrine tumors, further subdivided into tumors with benign and those with uncertain behavior well-differentiated (low grade) neuroendocrine carcinomas with low-grade malignant behavior poorly differentiated (high grade) neuroendocrine carcinomas, which are the large cell neuroendocrine and small cell carcinomas. (wikipedia.org)
In 1907, Oberndorfer[ 1 ] first introduced the term "carcinoid" to describe "little carcinomas" of the small intestine which were thought (by him at that time) to be probably benign. (wjgnet.com)
[ 4 ] but Oberndorfer called a group of small, benign-appearing tumors karzinoide tumoren (carcinoid) for the first time in 1907. (medscape.com)

Some carcinoid tumors produce symptoms that are not specific to this disease, such as facial flushing, diarrhea, abdominal pain, rash, and intestinal bleeding. (aacr.org)

However, the tumor biopsy revealed a malignant neoplasm that originating from neuroendocrine cells. (biomedcentral.com)

The prognosis for patients with GI carcinoid tumors is diverse. (elsevierpure.com)
These data therefore suggest that the outcomes of patients with carcinoid tumors are highly dependent on the presence of symptoms and the site of origin. (elsevierpure.com)
The five patients with tumors larger than 2 cm did well. (oncolink.org)
Analysis of Real-World Treatment Patterns, Healthcare Resource Utilization, and Costs Between Octreotide and Lanreotide Among Patients With Neuroendocrine Tumors. (harvard.edu)
Patients with locally staged carcinoids of the small bowel have an overall survival rate of 75%, which coincidentally approximates the statistics for carcinoid found within a Meckelâ€™s diverticulum. (radiologytoday.net)
Philippine Oncology Center Corporation, located in Quezon City, Metro Manila, Philippines offers patients Pancreatic Islet Cell Tumor Treatment procedures among its total of 107 available procedures, across 1 different specialties. (mymeditravel.com)
PHCT should be one of the differential diagnoses in patients with small hepatic tumor, even in regions with high prevalence of HBV infection and HCC. (biomedcentral.com)
Methods: Patients with rectal carcinoid tumors treated between January 1990 and March 2010 were identified retrospectively and classified into low- and high-risk groups. (elsevierpure.com)
Results: In total, 83 patients with rectal carcinoid tumors were included, 53 (64 %) of whom were identified as low-risk and 30 (36 %) as high-risk. (elsevierpure.com)

Despite these and other hurdles, the past 12 months brought remarkable progress in treating several rare tumors, leading to this area being named the Advance of the Year. (cancer.net)

There are many types of tumors that arise from the neuroendocrine system of which carcinoid tumors are the most common. (medifocus.com)
Carcinoid tumors arise from neuroendocrine cells, which are widespread in the human body, especially in the organs derived from the primitive intestine. (medscape.com)
In 1914, Gosset and Masson demonstrated that carcinoid tumors might arise from enterochromaffin cells (Kulchitsky cell) within glands of Lieberkühn using silver impregnation techniques. (medscape.com)

NORD gratefully acknowledges Simon Schimmack, MD, University Hospital of General, Visceral and Transplantation Surgery of Heidelberg, Germany, and Gastrointestinal Pathobiology Research Group, Department of Gastroenterological Surgery, Yale University School of Medicine, for assistance in the preparation of this report. (rarediseases.org)
Journal of Gastrointestinal Surgery , 18 (4), 768-773. (elsevierpure.com)

The hormones made by gastrointestinal carcinoid tumors are usually destroyed by liver enzymes in the blood. (myacare.com)
The resected liver tissue contained a 1.6 × 1.6 × 1.5 cm circumscribed tumor (Fig. 3 ). (biomedcentral.com)
Most of these tumors produce 5-hydroxytryptamine, which, in physiologic conditions, is taken up and stored in the platelets while the excesses are inactivated in the liver and lung and transformed into 5-hydroxyindoleacetic acid (5-HIAA). (medscape.com)

[ 6 ] In its 2015 consensus statement on best practices for pulmonary neuroendocrine tumors, the ENETS noted that tumor grading based on a combination of KI-67, mitotic rate, and necrosis may be of clinical importance but lacks validation. (medscape.com)

Carcinoid tumors and small-cell carcinomas of the gallbladder and extrahepatic bile ducts: a comparative study based on 221 cases from the Surveillance, Epidemiology, and End Results Program. (cancercentrum.se)

To the authors' knowledge, the 8305 carcinoid tumors analyzed represent the largest current epidemiology series to date. (nih.gov)

The highest percentage of nonlocalized lesions were noted for pancreatic (76.1%), colonic (71.2%), and small intestinal carcinoids (70.7%) and this corresponded to their poor 5-year survival rates (34.1%, 41.6%, and 55.4%, respectively). (nih.gov)

Diseases10

Chemicals and Drugs4

Carcinoid Tumor

Gastrointestinal Neoplasms

Appendiceal Neoplasms

Malignant Carcinoid Syndrome

Carcinoid Heart Disease

Ileal Neoplasms

Bronchial Neoplasms

Hydroxyindoleacetic Acid

Intestinal Neoplasms

Chromogranins

Octreotide

Neuroendocrine Tumors

Chromogranin A

ACTH Syndrome, Ectopic

Lung Neoplasms

Practice Guidelines as Topic

Neoplasm Staging

Guideline Adherence

Carcinoma, Neuroendocrine

Neuroendocrine tumor

Gastrointestinal cancer

Carcinoid

Appendix (anatomy)

Tumor of the stomach

Hormonal therapy (oncology)

5-Hydroxyindoleacetic acid

VIPoma

String sign

Computed tomography enterography

Liver cancer

Small intestine cancer

Enteroendocrine cell

Small intestine

Bone metastasis

Meckel's diverticulum

Goblet cell carcinoid

Enterochromaffin cell

List of cancer types

Endocrine oncology

Somatostatin

Appendix cancer

Armed Forces Institute of Pathology

Lanreotide

Octreotide

Carcinoid syndrome

Desmoplastic small-round-cell tumor

Friedrich Feyrter

Bronchiectasis

Otto Lubarsch

Neuroendocrine Tumors Guidelines: Initial Evaluation, Grading and Staging, Gastrointestinal and Pulmonary Carcinoid Tumors

Neuroendocrine Tumors Guidelines: Initial Evaluation, Grading and Staging, Gastrointestinal and Pulmonary Carcinoid Tumors

Treatment of Gastrointestinal Carcinoid Tumors | Mya Care

Gastrointestinal Carcinoid Tumors: Factors that Predict Outcome<...

Malignant Carcinoid Tumor of the Common Bile Duct: Report of a Case | SpringerLink

Pediatric Gastrointestinal Neuroendocrine Tumors Treatment (PDQ®) (Health professionals) | OncoLink

Neuroendocrine tumor - Wikipedia

November is November is Carcinoid Cancer Awareness Month | The AACR

Cancer Info | Vanderbilt-Ingram Cancer Center

Webpathology.com: A Collection of Surgical Pathology Images

Appendix Cancers | CancerIndex

Types of Appendiceal (Appendix) Cancer | Memorial Sloan Kettering Cancer Center

Small Intestine Cancer | Bowel Cancer | Small Bowel Cancer

An analysis of 8305 cases of carcinoid tumors

Colon cancer diagnosis and treatment at UCHealth | Colorado

Appendiceal neuroendocrine tumors: Recent insights and clinical implications

Medifocus Guidebook on Carcinoid Tumors

Streptozocin | CancerIndex

Small Intestine Cancer Misdiagnosis Lawyer | MedicalMalpracticeHelp.com

Malignant Carcinoid Syndrome | Harvard Catalyst Profiles | Harvard Catalyst

Collision tumors in the gastrointestinal tract: a rare case series | IMCRJ

figure52 - Endotext

Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management | Cardiology | Karger Publishers

Daniel C. Chung, MD - DF/HCC

Pancreatic Neuroendocrine Neoplasms (pNENs) - Symptoms, Causes, Treatment | NORD

Biomarker Phenotypes in Heart Failure with Preserved Ejection Fraction Using Hierarchical Clustering: A Pilot Study | Medical...

AMCP Nexus 2017 Highlights

Progress in Treating Rare Cancers: The 2019 Advance of the Year | Cancer.Net

Chemotherapy and Medical Oncology - BJC HealthCare

Michigan Mesothelioma Doctors, Cancer Centers & Treatment

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