Gastrointestinal Agents
Health Priorities
Social Responsibility
Achievement
Public Health
Delivery of Health Care
Enterobacteriaceae
A family of gram-negative, facultatively anaerobic, rod-shaped bacteria that do not form endospores. Its organisms are distributed worldwide with some being saprophytes and others being plant and animal parasites. Many species are of considerable economic importance due to their pathogenic effects on agriculture and livestock.
Fermentation
Evaluation Studies as Topic
Nursing Homes
Pharmaceutical Preparations
Dictionaries as Topic
Terminology as Topic
Hydrogen Sulfide
Cystathionine gamma-Lyase
Sulfides
Dysbiosis
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Gastrointestinal Tract
Microbiota
Tooth Preparation, Prosthodontic
The selected form given to a natural tooth when it is reduced by instrumentation to receive a prosthesis (e.g., artificial crown or a retainer for a fixed or removable prosthesis). The selection of the form is guided by clinical circumstances and physical properties of the materials that make up the prosthesis. (Boucher's Clinical Dental Terminology, 4th ed, p239)
Swine
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
Carbon Dioxide
Mesenteric Arteries
Oxygen
Platelet Aggregation Inhibitors
Phenindione
Warfarin
An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.
Persistent Vegetative State
Aspirin
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Ticlopidine
Suspensions
Food-Drug Interactions
Antifungal Agents
Tablets
Itraconazole
Drug Interactions
Product Labeling
Health Resources
Magnetic Resonance Imaging
Microbubbles
Small encapsulated gas bubbles (diameters of micrometers) that can be used as CONTRAST MEDIA, and in other diagnostic and therapeutic applications. Upon exposure to sufficiently intense ultrasound, microbubbles will cavitate, rupture, disappear, release gas content. Such characteristics of the microbubbles can be used to enhance diagnostic tests, dissolve blood clots, and deliver drugs or genes for therapy.
Gadolinium
Barium Sulfate
Delayed gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy: effect of postoperative time and cisapride. (1/1045)
OBJECTIVE: To study the recovery course of gastric emptying after Billroth I pylorus-preserving pancreatoduodenectomy (PPPD) and therapeutic effects of cisapride. METHODS: To examine gastric emptying, acetaminophen was given, admixed in a pasty liquid meal, to 16 patients undergoing PPPD before surgery and at 1, 3, 6, 9, and 12 months after surgery. Cisapride was given orally to 10 patients before they received the acetaminophen regimen. Electrogastrography was performed at 2 weeks to 1 month after surgery in eight patients and at 6 to 12 months after surgery in seven patients. RESULTS: Gastric emptying was delayed but returned to the preoperative level by 6 months after surgery. Pretreatment with cisapride accelerated gastric emptying during months 1 to 6 but not during months 6 to 12 after surgery. Electrogastrography frequently showed tachygastria 2 weeks to 1 month after surgery, but seldom 6 to 12 months after surgery. CONCLUSIONS: After Billroth I PPPD, gastric emptying is delayed but recovers by 6 months after surgery. Tachygastria may play a part in the pathogenesis of delayed gastric emptying, but it can be treated with cisapride. (+info)Erythromycin enhances early postoperative contractility of the denervated whole stomach as an esophageal substitute. (2/1045)
OBJECTIVE: To determine whether early postoperative administration of erythromycin accelerates the spontaneous motor recovery process after elevation of the denervated whole stomach up to the neck. SUMMARY BACKGROUND DATA: Spontaneous motor recovery after gastric denervation is a slow process that progressively takes place over years. METHODS: Erythromycin was administered as follows: continuous intravenous (i.v.) perfusion until postoperative day 10 in ten whole stomach (WS) patients at a dose of either 1 g (n = 5) or 2 g (n = 5) per day; oral intake at a dose of 1 g/day during 1.5 to 8 months after surgery in 11 WS patients, followed in 7 of them by discontinuation of the drug during 2 to 4 weeks. Gastric motility was assessed with intraluminal perfused catheters in these 21 patients, in 23 WS patients not receiving erythromycin, and in 11 healthy volunteers. A motility index was established by dividing the sum of the areas under the curves of >9 mmHg contractions by the time of recording. RESULTS: The motility index after IV or oral administration of erythromycin at and after surgery was significantly higher than that without erythromycin (i.v., 1 g: p = 0.0090; i.v., 2 g: p = 0.0090; oral, 1 g: p = 0.0017). It was similar to that in healthy volunteers (i.v., 1 g: p = 0.2818; oral, 1 g: p = 0.7179) and to that in WS patients with >3 years of follow-up who never received erythromycin (i.v., 1 g: p = 0.2206; oral, 1 g: p = 0.8326). The motility index after discontinuation of the drug was similar or superior to that recorded under medication in four patients who did not experience any modification of their alimentary comfort, whereas it dropped dramatically parallel to deterioration of the alimentary comfort in three patients. CONCLUSIONS: Early postoperative contractility of the denervated whole stomach pulled up to the neck under either i.v. or oral erythromycin is similar to that recovered spontaneously beyond 3 years of follow-up. In some patients, this booster effect persists after discontinuation of the drug. (+info)Octreotide acetate long-acting formulation versus open-label subcutaneous octreotide acetate in malignant carcinoid syndrome. (3/1045)
PURPOSE: Subcutaneous (SC) octreotide acetate effectively relieves the diarrhea and flushing associated with carcinoid syndrome but requires long-term multiple injections daily. A microencapsulated long-acting formulation (LAR) of octreotide acetate has been developed for once-monthly intramuscular dosing. PATIENTS AND METHODS: A randomized trial compared double-blinded octreotide LAR at 10, 20, and 30 mg every 4 weeks with open-label SC octreotide every 8 hours for the treatment of carcinoid syndrome. Seventy-nine patients controlled with treatment of SC octreotide 0.3 to 0.9 mg/d whose symptoms returned during a washout period and who returned for at least the week 20 evaluation constituted the efficacy-assessable population. RESULTS: Complete or partial treatment success was comparable in each of the four arms of the study (SC, 58.3%; 10 mg, 66.7%; 20 mg, 71.4%; 30 mg, 61.9%; P> or =.72 for all pairwise comparisons). Control of stool frequency was similar in all treatment groups. Flushing episodes were best controlled in the 20-mg LAR and SC groups; the 10-mg LAR treatment was least effective in the control of flushing. Treatment was well tolerated by patients in all four groups. CONCLUSION: Once octreotide steady-state concentrations are achieved, octreotide LAR controls the symptoms of carcinoid syndrome at least as well as SC octreotide. A starting dose of 20 mg of octreotide LAR is recommended. Supplemental SC octreotide is needed for approximately 2 weeks after initiation of octreotide LAR treatment. Occasional rescue SC injections may be required for possibly 2 to 3 months until steady-state octreotide levels from the LAR formulation are achieved. (+info)Is maintenance therapy always necessary for patients with ulcerative colitis in remission? (4/1045)
BACKGROUND: The efficacy of sulphasalazine and mesalazine in preventing relapse in patients with ulcerative colitis is well known. It is less clear how long such maintenance should be continued, and if the duration of disease remission is a factor that affects the risk of recurrence. AIM: To determine whether the duration of disease remission affects the relapse rate, by comparing the efficacy of a delayed-release mesalazine (Asacol, Bracco S.p.A., Milan, Italy) against placebo in patients with ulcerative colitis with short- and long-duration of disease remission. METHODS: 112 patients (66 male, 46 female, mean age 35 years), with intermittent chronic ulcerative colitis in clinical, endoscopic and histological remission with sulphasalazine or mesalazine for at least 1 year, were included in the study. Assuming that a lower duration of remission might be associated with a higher relapse rate, the patients were stratified according to the length of their disease remission, prior to randomization into Group A (Asacol 26, placebo 35) in remission from 1 to 2 years, or Group B (Asacol 28, placebo 23) in remission for over 2 years, median 4 years. Patients were treated daily with oral Asacol 1.2 g vs. placebo, for a follow-up period of 1 year. RESULTS: We employed an intention-to-treat analysis. In Group A, whilst no difference was found between the two treatments after 6 months, mesalazine was significantly more effective than placebo in preventing relapse at 12 months [Asacol 6/26 (23%), placebo 17/35 (49%), P = 0.035, 95% Cl: 48-2.3%]. In contrast, in Group B no statistically significant difference was observed between the two treatments, either at 6 or 12 months [Asacol 5/28 (18%), placebo 6/23 (26%), P = 0.35, 95% Cl: 31-14%] of follow-up. Patients in group B were older, and had the disease and remission duration for longer, than those in Group A. CONCLUSIONS: Mesalazine prophylaxis is necessary for the prevention of relapse by patients with ulcerative colitis in remission for less than 2 years, but this study casts doubt over whether continuous maintenance treatment is necessary in patients with prolonged clinical, endoscopic and histological remission, who are at very low risk of relapse. (+info)Bile salts: natural detergents for the prevention of sexually transmitted diseases. (5/1045)
The development of new, safe, topical microbicides for intravaginal use for the prevention of sexually transmitted diseases is imperative. Previous studies have suggested that bile salts may inhibit human immunodeficiency virus infection; however, their activities against other sexually transmitted pathogens have not been reported. To further explore the potential role of bile salts in preventing sexually transmitted diseases, we examined the in vitro activities and cytotoxicities of select bile salts against Chlamydia trachomatis, herpes simplex virus (types 1 and 2), Neisseria gonorrhoeae, and human immunodeficiency virus in comparison to those of nonoxynol-9 and benzalkonium chloride using both primary cells and cell lines derived from the human female genital tract. We found that taurolithocholic acid 3-sulfate and a combination of glycocholic acid and taurolithocholic acid 3-sulfate showed excellent activity against all of the pathogens assayed. Moreover, taurolithocholic acid 3-sulfate alone or in combination was less cytotoxic than nonoxynol-9 and benzalkonium chloride. Thus, taurolithocholic acid 3-sulfate alone or in combination warrants further evaluation as a candidate topical microbicidal agent. (+info)Clinical considerations in GERD (gastroesophageal reflux disease) therapy: focus on cisapride. (6/1045)
Heartburn, the major symptom of gastrointestinal reflux disease (GERD), is a common condition that is usually self-treated with over-the-counter products. For patients with severe or recurrent symptoms of GERD, pharmacologic therapy includes acid suppression with H2-receptor antagonists and proton pump inhibitors, and, alternatively, the use of prokinetic agents. While all of these are efficacious, given its high efficacy in nonerosive and mild-to-moderate erosive esophagitis, the prokinetic agent cisapride deserves significant consideration in this patient population. (+info)Influence of erythromycin on establishment of feeding in preterm infants: observations from a randomised controlled trial. (7/1045)
AIM: To determine the effect of erythromycin on the establishment of enteral feeding in ventilated infants < 31 weeks gestation. METHODS: Erythromycin was randomly allocated as an antimicrobial treatment for the first 7 days of life in 76 infants: 35 received erythromycin and 41 acted as controls. Feed toleration, time taken to establish full enteral feeding, vomiting, prescription of glycerine suppositories and occurrence of necrotising enterocolitis were recorded. RESULTS: There were no significant differences between the groups for any of the outcomes. The infants treated with erythromycin reached full feeding at a median (quartile) age of 8 (5-12) days compared with 9 (6-14) days for controls. CONCLUSIONS: Intravenous erythromycin in antimicrobial doses is unlikely to benefit the introduction of feeding in preterm infants. (+info)Characterization of a Na+-dependent betaine transporter with Cl- channel properties in squid motor neurons. (8/1045)
Most marine invertebrates, including squids, use transporters to accumulate organic osmolytes such as betaine, to prevent water loss when exposed to elevated salinity. Although a limited number of flux studies have shown the Na+ dependence of betaine transport, nothing is known about the electrogenic properties of osmolyte transporters. We used whole cell and perforated-patch voltage-clamp techniques to characterize the electrical properties of the betaine transporter in giant fiber lobe motor neurons of the squid Lolliguncula brevis. Betaine activated a large, Cl--selective current that was reversibly blocked by 100 microM niflumic acid (97 +/- 2% block after 40 s, SD; n = 7) and partially inhibited by 500 microM SITS (29 +/- 11%; n = 5). The Cl- current was Na+ dependent and was virtually eliminated by isotonic replacement of Na+ with Li+, NMDG+, or Tris+. Concentration-response data revealed an EC50 in a physiologically relevant range for these animals of 5.1 +/- 0.9 mM (n = 11). In vertebrates, the betaine transporter is structurally related to the GABA transporter, and although GABA did not directly activate the betaine-induced current, it reversibly reduced betaine responses by 34 +/- 14% (n = 8). Short-term changes in osmolality alone did not activate the Cl- current, but when combined with betaine, Cl- currents increased in hypertonic solutions and decreased in hypotonic solutions. Activation of the betaine transporter and Cl- current in hypertonic conditions may affect both volume regulation and excitability in L. brevis motor neurons. This study is the first report of a novel betaine transporter in neurons that can act as a Cl- channel. (+info)
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Gastrointestinal agents
Gastrointestinal agents
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Erythromycin
... a motilin agonist and gastrointestinal prokinetic agent". The American Journal of Gastroenterology. 88 (4): 485-90. PMID ... If mitemcinal can be shown to be an effective prokinetic agent, it would represent a significant advance in the ... August 2016). "The efficacy and safety of prokinetic agents in critically ill patients receiving enteral nutrition: a ... Antimicrobial Agents and Chemotherapy. 28 (5): 630-3. doi:10.1128/aac.28.5.630. PMC 176346. PMID 4091529. Pal S (2006). "A ...
Double-contrast barium enema
Contrast agent Lower gastrointestinal series Cittadini, Giorgio (2012). Double contrast barium enema: The Genoa approach. ... A liquid containing barium (that is, a radiocontrast agent) is put into the rectum. Barium is a silver-white metallic compound ... Stringer, David A.; Babyn, Paul S. (2000). Pediatric Gastrointestinal Imaging and Intervention. PMPH-USA. p. 38. ISBN ...
Bile acid
"Bile acids as endogenous etiologic agents in gastrointestinal cancer". World J. Gastroenterol. 15 (27): 3329-40. doi:10.3748/ ... Gastrointestinal and Liver Physiology. 318 (3): G554-G573. doi:10.1152/ajpgi.00223.2019. PMC 7099488. PMID 31984784. Kim, I; ... is a semi-synthetic bile acid with greater activity as FXR agonist which is undergoing investigation as a pharmaceutical agent ...
Carcinogen
Bernstein H, Bernstein C, Payne CM, Dvorak K (July 2009). "Bile acids as endogenous etiologic agents in gastrointestinal cancer ... Genotoxins include chemical agents like N-nitroso-N-methylurea (NMU) or non-chemical agents such as ultraviolet light and ... Lead and its compounds Alkylating antineoplastic agents (e.g. mechlorethamine) Styrene Other alkylating agents (e.g. dimethyl ... Group 3: the agent (mixture or exposure circumstance) is not classifiable as to its carcinogenicity to humans. Group 4: the ...
Benoxaprofen
Somerville KW, Hawkey CJ (January 1986). "Non-steroidal anti-inflammatory agents and the gastrointestinal tract". Postgraduate ... In three of the six species benoxaprofen was then effectively taken up from the gastrointestinal tract (after oral doses of 1- ... The free radical decarboxylated derivative of the drug is the toxic agent which, in the presence of oxygen, yields singlet ... Gastrointestinal side effects of benoxaprofen are bleeding, diarrhoea, abdominal pain, anorexia (symptom), mouth ulcers and ...
Basidiobolus ranarum
Although rarely, the agent can cause gastrointestinal disease which does not show specific vulnerable groups or risk factors. ... "Basidiobolus ranarum as an Etiologic Agent of Gastrointestinal Zygomycosis". Journal of Clinical Microbiology. 39 (6): 2360- ... As well, the agent may transmit through traumas or insect bites on skin. Most of the reported cases were from Nigeria and ... Ingestion of B. ranarum is thought to help disperse the agent through the deposition of feces at a distant place where human ...
Adderall
Gastrointestinal alkalizing (acidifying) agents increase the absorption of amphetamine. Urinary alkalizing (acidifying) agents ... Such agents also have important therapeutic uses; cocaine, for example, is used as a local anesthetic (Chapter 2), and ... Duration of effect varies depending on agent and urine pH. Excretion is enhanced in more acidic urine. Half-life is 7 to 34 ... Gastrointestinal side effects may include abdominal pain, constipation, diarrhea, and nausea. Other potential physical side ...
Probiotic
Gismondo MR, Drago L, Lombardi A (1999). "Review of probiotics available to modify gastrointestinal flora". Int. J. Antimicrob ... Alvarez-Olmos MI, Oberhelman RA (2001). "Probiotic agents and infectious diseases: a modern perspective on a traditional ... International Journal of Antimicrobial Agents. 22 (4): 360-6. doi:10.1016/S0924-8579(03)00153-5. PMID 14522098.. ... such as reducing gastrointestinal discomfort, improving immune health,[8] relieving constipation, or avoiding the common cold, ...
Laktulosa, entziklopedia askea.
gastrointestinal agent (en) Identifikatzaileak. InChlKey. JCQLYHFGKNRPGE-FCVZTGTOSA-N. CAS zenbakia. 4618-18-2. ...
Carcinogen
"Bile acids as endogenous etiologic agents in gastrointestinal cancer". World J Gastroenterol. 15 (27): 3329-3340. doi:10.3748/ ... Genotoxins include chemical agents like N-nitroso-N-methylurea (NMU) or non-chemical agents such as ultraviolet light and ... Occupational carcinogens are agents that pose a risk of cancer in several specific work-locations:. Carcinogen. Associated ... Group 4: the agent (mixture) is probably not carcinogenic to humans.. Globally Harmonized SystemEdit. The Globally Harmonized ...
Carcinogen
"Bile acids as endogenous etiologic agents in gastrointestinal cancer". World Journal of Gastroenterology. 15 (27): 3329-40. doi ... Genotoxins include chemical agents like N-nitroso-N-methylurea (NMU) or non-chemical agents such as ultraviolet light and ... Occupational carcinogens are agents that pose a risk of cancer in several specific work-locations: Carcinogen. Associated ... Group 2A: the agent (mixture) is probably (product more likely to be) carcinogenic to humans. The exposure circumstance entails ...
Hyperkalemia
Potassium can bind to agents in the gastrointestinal tract.[34][35] Sodium polystyrene sulfonate with sorbitol (Kayexalate) has ... 2013). "Gastrointestinal adverse events with sodium polystyrene sulfonate (kayexalate) use: a systematic review.". Am J Med. ... Patiromer is a selective sorbent that is taken by mouth and works by binding free potassium ions in the gastrointestinal tract ... Potassium is eliminated from the body through the gastrointestinal tract, kidney and sweat glands. In the kidneys, elimination ...
Loperamide
Mediators and Drugs in Gastrointestinal Motility II: Endogenous and Exogenous Agents. Springer Science & Business Media. 6 ... Schuermans V, Van Lommel R, Dom J, Brugmans J (1974). "Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 6: ... It is an antifoaming agent used to reduce bloating, discomfort, or pain caused by excessive gas. Drugs.com International brands ... Loperamide is an antidiarrheal agent, which decreases intestinal movement. As such, when combined with other antimotility drugs ...
Kidney disease
Less commonly gastrointestinal or urinary infection can be the inciting agent. All of these infections have in common the ... Several chemotherapeutic agents, for example Cisplatin, are associated with acute and chronic kidney injuries. Newer agents ... toxicity of chemotherapy agents, and long-term exposure to lead or its salts. Chronic conditions that can produce nephropathy ... Anti-Allergy Agents in Medicinal Chemistry. 5 (2): 139-146. doi:10.2174/187152306776872442. Grünfeld, JP; Rossier, BC (May 2009 ...
Trimebutine
"Effectiveness of prokinetic agents against diseases external to the gastrointestinal tract" (PDF). Journal of Gastroenterology ... It is used for the treatment of irritable bowel syndrome and other gastrointestinal disorders. The major product from drug ...
Hyperkalemia
Potassium can bind to a number of agents in the gastrointestinal tract. Sodium polystyrene sulfonate with sorbitol (Kayexalate ... 2013). "Gastrointestinal adverse events with sodium polystyrene sulfonate (kayexalate) use: a systematic review". Am J Med. 126 ... Patiromer is taken by mouth and works by binding free potassium ions in the gastrointestinal tract and releasing calcium ions ... Potassium is eliminated from the body through the gastrointestinal tract, kidney and sweat glands. In the kidneys, elimination ...
Erythromycin
Weber FH, Richards RD, McCallum RW (April 1993). "Erythromycin: a motilin agonist and gastrointestinal prokinetic agent". The ... "Antimicrobial Agents and Chemotherapy. 12 (5): 630-5. doi:10.1128/AAC.12.5.630. PMC 429989. PMID 21610.. ... "Antimicrobial Agents and Chemotherapy. 28 (5): 630-3. doi:10.1128/aac.28.5.630. PMC 176346. PMID 4091529.. ... Gastrointestinal disturbances, such as diarrhea, nausea, abdominal pain, and vomiting, are very common because erythromycin is ...
Endometriosis
COX-2 selective agents such as celecoxib have a more limited gastrointestinal toxicity. NSAID injections of ketorolac can be ... These agents, although efficacious, were associated with intolerable side effects. The current armamentarium of hormonal agents ... Both agents inhibit the growth of endometriosis but their use has declined, due in part to virilizing side effects such as ... Pentoxifylline, an immunomodulating agent, has been theorized to improve pain as well as improve pregnancy rates in individuals ...
Radiation enteropathy
"Systematic review of agents for the management of gastrointestinal mucositis in cancer patients". Support Care Cancer. 21 (1): ... New agents have been identified in animal studies that may have effects on intestinal radiation injury. The research approach ... People who have been treated with radiotherapy for pelvic and other abdominal cancers frequently develop gastrointestinal ... nutritional deficiencies and weight loss abdominal pain and bloating nausea, vomiting and fatigue Gastrointestinal symptoms are ...
Irritable bowel syndrome
Lubiprostone is a gastrointestinal agent used for the treatment of constipation-predominant IBS. The use of antispasmodic drugs ... Sperber AD, Dekel R (April 2010). "Irritable Bowel Syndrome and Co-morbid Gastrointestinal and Extra-gastrointestinal ... It acts as a bulking agent, and for many people with IBS-D, allows for a more consistent stool. For people with IBS-C, it seems ... Ferguson LR, Laing B, Marlow G, Bishop K (January 2016). "The role of vitamin D in reducing gastrointestinal disease risk and ...
Innate immune system
... helps remove infectious agents.[2] Also, mucus traps infectious agents.[2] The gut flora can prevent the colonization of ... Gastrointestinal tract. Peristalsis, gastric acid, bile acids, digestive enzyme,. flushing, thiocyanate,[2] defensins,[2] gut ... Acting as a physical and chemical barrier to infectious agents; via physical measures like skin or tree bark and chemical ... The epithelial surfaces form a physical barrier that is impermeable to most infectious agents, acting as the first line of ...
Krwawienie z przewodu pokarmowego, wolna encyklopedia
Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents ... Gastrointestinal Bleeding in Cirrhotic Patients with Portal Hypertension. „Hepatology", 2013. *↑ a b c d e f g h i j k l m n o ... An approach to gastrointestinal haemorrhage. „Veterinary Ireland Journa". *↑ a b c d e f g Deborah Silverstein, Kate Hopper: ... a b c d e Anthony J. DiMarino, Stanley B. Benjamin: Gastrointestinal Disease: An Endoscopic Approach. SLACK Incorporated, 2002 ...
Antiparasitic
... a broad-spectrum thiazolide anti-infective agent for the treatment of gastrointestinal infections". Expert Opin Pharmacother. 7 ... A causative agent for eye keratitis infection". Spectrochimica Acta Part A: Molecular Spectroscopy. 153: 714-21. Bibcode: ... Anderson, V. R.; Curran, M. P. (2007). "Nitazoxanide: A review of its use in the treatment of gastrointestinal infections". ... Antiparasitics target the parasitic agents of the infections by destroying them or inhibiting their growth; they are usually ...
Turbinellus kauffmanii
It is likely the agent responsible for toxic (gastrointestinal) symptoms that occur in T. floccosus. It was described in 1947 ...
Azapirone
"Effects on gastrointestinal functions and symptoms of serotonergic psychoactive agents used in functional gastrointestinal ... As a result, further development has commenced to bring more selective of anxiolytic agents to the market. An example of this ... Bouwer C, Stein DJ (April 1997). "Buspirone is an effective augmenting agent of serotonin selective re-uptake inhibitors in ... Evidence is not clear for panic disorder and functional gastrointestinal disorders. Side effects of azapirones may include ...
Kidney disease
Less commonly gastrointestinal or urinary infection can be the inciting agent. All of these infections have in common the ... Several chemotherapeutic agents, for example Cisplatin, are associated with acute and chronic kidney injuries.[20] Newer agents ... Toxicity of chemotherapy agentsEdit. Main article: Onconephrology. Nephropathy can be associated with some therapies used to ... Anti-Allergy Agents in Medicinal Chemistry. 5 (2): 139-146. doi:10.2174/187152306776872442.. ...
Dexloxiglumide
Roberts DJ, Banh HL, Hall RI (August 2006). "Use of novel prokinetic agents to facilitate return of gastrointestinal motility ... It inhibits gastrointestinal motility and reduces gastric secretions, and despite older selective CCKA antagonists such as ... Galligan JJ, Vanner S (October 2005). "Basic and clinical pharmacology of new motility promoting agents". Neurogastroenterology ... dexloxiglumide is being investigated as a potential treatment for a variety of gastrointestinal problems including irritable ...
Açaí palm
Orally administered açaí has been tested as a contrast agent for magnetic resonance imaging (MRI) of the gastrointestinal ... April 2004). "Euterpe olerácea (Açaí) as an alternative oral contrast agent in MRI of the gastrointestinal system: preliminary ... Its anthocyanins have also been characterized for stability as a natural food coloring agent. A grove of açaí palms in Brazil ...
Anti-obesity medication
ISBN 978-0-312-42785-6. "Obesity Medication: Gastrointestinal Agents, Other, CNS Stimulants, Anorexiants, Glucagon-like Peptide ... Anti-obesity medication or weight loss medications are pharmacological agents that reduce or control weight. These medications ... Catecholamine releasing agents such as amphetamine, phentermine, and related substituted amphetamines (e.g., bupropion) which ...
Cilomilast
The rejection was based on concerns over the efficacy of the agent, as well as gastrointestinal side effects. Before issuing ... the clinical benefits of these agents have never been shown to outweigh the risks of their numerous adverse effects. Four ...
Bile acid
"Bile acids as endogenous etiologic agents in gastrointestinal cancer". World J. Gastroenterol. 15 (27): 3329-40. doi:10.3748/ ... Gastrointestinal and Liver Physiology. 318 (3): G554-G573. doi:10.1152/ajpgi.00223.2019. PMC 7099488. PMID 31984784.. ... is a semi-synthetic bile acid with greater activity as FXR agonist which is undergoing investigation as a pharmaceutical agent ...
Lipid-lowering agent
Bile acid sequestrants may cause gastrointestinal problems and may also reduce the absorption of other drugs and vitamins from ... Hypolipidemic agents, cholesterol-lowering drugs or antihyperlipidemic agents, are a diverse group of pharmaceuticals that are ... Investigational classes of hypolipidemic agents: *CETP inhibitors (cholesteryl ester transfer protein), 1 candidate is in ... the choice of an agent depends on the patient's cholesterol profile, cardiovascular risk, and the liver and kidney functions of ...
Eating
Those species that seek pest insects are considered beneficial 'biological control agents' and their presence encouraged in ... There are environmental signals, signals from the gastrointestinal system, and metabolic signals that trigger hunger. The ...
Indinavir
97 patients were randomly assigned to one of the three groups: indinavir monotherapy, AZT and lamivudine, or all three agents. ... Gastrointestinal disturbances (abdominal pain, diarrhea, nausea, vomiting)[4]. *General malaise and fatigue[4] ...
Ebola
... virus is classified as a biosafety level 4 agent, as well as a Category A bioterrorism agent by the Centers for Disease ... it is usually in the gastrointestinal tract.[35] The incidence of bleeding into the gastrointestinal tract was reported to be ~ ... Zubray G (2013). Agents of Bioterrorism: Pathogens and Their Weaponization. New York, NY, USA: Columbia University Press. pp. ... Sharma N, Cappell MS (September 2015). "Gastrointestinal and Hepatic Manifestations of Ebola Virus Infection". Digestive ...
Acne
Hormonal agents[edit]. In women, the use of combined birth control pills can improve acne.[100] These medications contain an ... appears to have similar efficacy to 100 milligrams daily and has fewer gastrointestinal side effects.[15] However, low-dose ... "Antimicrobial Agents and Chemotherapy. 63 (1). doi:10.1128/AAC.01297-18. PMC 6325184. PMID 30397052.. ... Hassoun LA, Chahal DS, Sivamani RK, Larsen LN (June 2016). "The use of hormonal agents in the treatment of acne". Seminars in ...
Radiography
Main article: Radiocontrast agent. Contrast radiography uses a radiocontrast agent, a type of contrast medium, to make the ... Upper gastrointestinal series/Small-bowel follow-through/Lower gastrointestinal series. *Cholangiography/Cholecystography ... Contrast agents are required in conventional angiography, and can be used in both projectional radiography and computed ... Quader MA, Sawmiller CJ, Sumpio BE (2000). "Radio Contrast Agents: History and Evolution". Textbook of Angiology. pp. 775-783. ...
Yellow fever
A local doctor concluded that some unspecified infectious agent had arrived in a package from New Orleans.[74][75] 650 ... and the gastrointestinal tract cause vomit containing blood, hence the Spanish name for yellow fever, vómito negro ("black ... The mosquito hypothetically considered as an agent in the transmission of yellow fever) Anales de la Real Academia de Ciencias ... "The mosquito hypothetically considered as an agent in the transmission of yellow fever poison," Archived 2017-02-23 at the ...
Benzo(a)pyrene
Chemical agents and related occupations, Volume 10, A review of Human Carcinogens, IARC Monographs, Lyon France 2009 [13] ... because the gastrointestinal tract protects itself against carcinomas by shedding its outer layer continuously.[citation needed ... A review of human carcinogens-part F: chemical agents and related occupations ... "Basal and inducible CYP1 mRNA quantitation and protein localization throughout the mouse gastrointestinal tract". Free Radic ...
Beta-glucan
... β-glucans are used as texturing agents in various nutraceutical and cosmetic products, and as soluble fiber supplements. ... "Understanding the Physics of Functional Fibers in the Gastrointestinal Tract: An Evidence-Based Approach to Resolving Enduring ... "High-Amylose Resistant Starch Increases Hormones and Improves Structure and Function of the Gastrointestinal Tract: A ...
JC virus
The initial site of infection may be the tonsils,[4] or possibly the gastrointestinal tract.[5] The virus then remains latent ... The JCV virus may also be a causative agent of aseptic meningitis (JCVM), as JCV was the only pathogen identified in the CSF of ... "JC virus DNA sequences are frequently present in the human upper and lower gastrointestinal tract". Gastroenterology. 119 (5): ... recent literature has identified viral variants as etiological agents of other novel syndromes. For example, JCV has been found ...
Chronic obstructive pulmonary disease
... long-acting agents are recommended.[2] Long-acting agents partly work by reducing hyperinflation.[74] If long-acting ... Roflumilast and cilomilast may be associated with side effects such as gastrointestinal issues and weight loss. Sleep ... External agents/. occupational. lung disease. Pneumoconiosis Aluminosis. Asbestosis. Baritosis. Bauxite fibrosis. Berylliosis. ... Several new long-acting agents are under development.[2] Treatment with stem cells is under study.[201] While there is ...
Hepatit - Vikipedi
April 2011). "[Abdominal and gastrointestinal symptoms of Dengue fever. Analysis of a cohort of 8559 patients]". Gastroenterol ... "Opisthorchis felineus and Metorchis bilis are the main agents of liver fluke infection of humans in Russia". Parasitol. Int ... Organ EL, Rubin DH (1998). "Pathogenesis of reovirus gastrointestinal and hepatobiliary disease". Curr. Top. Microbiol. Immunol ... "Gastrointestinal and hepatic manifestations of tickborne diseases in the United States". Clin. Infect. Dis. 34 (9), s. 1206-12 ...
Isotretinoin
Gastrointestinal[edit]. Isotretinoin may cause non-specific gastrointestinal symptoms including nausea, diarrhea and abdominal ...
Anxiety
"CDC - The Emergency Response Safety and Health Database: Systemic Agent: BENZENE - NIOSH". www.cdc.gov. Archived from the ... gastrointestinal diseases (celiac disease, non-celiac gluten sensitivity, inflammatory bowel disease),[73][74][75] heart ... parental discouragement of anger may result in repression/suppression of angry feelings which manifests as gastrointestinal ...
Urinary tract infection
"Antimicrobial agents for treating uncomplicated urinary tract infection in women". Cochrane Database of Systematic Reviews. 10 ... with gastrointestinal upset occurring in more than 30%.[62] Cranberry juice is thus not currently recommended for this ... Methenamine is another agent used for this purpose as in the bladder where the acidity is low it produces formaldehyde to which ... Medications that commonly cause this problem include the chemotherapeutic agent cyclophosphamide with rates of 2 to 40%.[47] ...
Vitamin C
Ascorbic acid is a common enzymatic cofactor in mammals used in the synthesis of collagen, as well as a powerful reducing agent ... Vitamin C is generally well tolerated.[2] Large doses may cause gastrointestinal discomfort, headache, trouble sleeping, and ... Oxidized forms of the molecule such as dehydroascorbic acid are converted back to ascorbic acid by reducing agents.[3] ... Uric acid and ascorbate are both strong reducing agents. This has led to the suggestion that, in higher primates, uric acid has ...
Cholangiocarcinoma
Chemotherapy agents used to treat cholangiocarcinoma include 5-fluorouracil with leucovorin,[79] gemcitabine as a single agent, ... 21 July 2006). Sleisenger and Fordtran's Gastrointestinal and Liver Disease (8th ed.). Saunders. pp. 1493-6. ISBN 978-1-4160- ... Park JS, Oh SY, Kim SH, Kwon HC, Kim JS, Jin-Kim H, Kim YH (February 2005). "Single-agent gemcitabine in the treatment of ... Journal of Gastrointestinal Cancer. 43 (2): 137-47. doi:10.1007/s12029-011-9284-y. PMID 21597894.. ...
Actinomycetales
... and gastrointestinal tract in the form of Helicobacter without causing disease in the host. They also have wide medicinal and ... and can also serve as growth promoting or biocontrol agents, or cause disease in some species of plants. Actinomycetales can be ...
SIDA, a enciclopedia libre
"Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection" (PDF). The Panel on Antiretroviral Therapy and ... Tamén está ligada á caída do sistema de vixilancia inmunitaria da barreira da mucosa gastrointestinal causada pola diminución ... Panel on Antiretroviral Guidelines for Adults and Adolescents (2009-12-01). Guidelines for the use of antiretroviral agents in ... Coovadia H (2004). "Antiretroviral agents-how best to protect infants from HIV and save their mothers from AIDS". N. Engl. J. ...
Enterococcus faecium
"Antimicrobial Agents and Chemotherapy. 55 (3): 1162-72. doi:10.1128/AAC.01402-10. PMC 3067123. PMID 21173186.. ... in the gastrointestinal tract of humans and animals,[2] but it may also be pathogenic, causing diseases such as neonatal ...
Radiation therapy
The gastrointestinal tract can be damaged following abdominal and pelvic radiotherapy.[22] Atrophy, fibrosis and vascular ... of the radioactive agents being infused.[15] Methods, techniques and devices are available to lower the occurrence of this type ... "Gastrointestinal complications associated with hepatic arterial Yttrium-90 microsphere therapy". Journal of vascular and ... These medications were the first agents of what is known as radioimmunotherapy, and they were approved for the treatment of ...
Medical microbiology
Identification of an infectious agent for a minor illness can be as simple as clinical presentation; such as gastrointestinal ... The antigen (usually a protein or carbohydrate made by an infectious agent) is bound by the antibody, allowing this type of ... Fast and relatively simple biochemical tests can be used to identify infectious agents. For bacterial identification, the use ... Using a similar basis as described above, immunoassays can detect or measure antigens from either infectious agents or the ...
Influenza
"Antimicrobial Agents and Chemotherapy. 38 (8): 1864-67. doi:10.1128/aac.38.8.1864. PMC 284652. PMID 7986023.. ... In children, gastrointestinal symptoms such as vomiting, diarrhea, and abdominal pain,[21][22] (may be severe in children with ... The first influenza virus to be isolated was from poultry, when in 1901 the agent causing a disease called "fowl plague" was ... "High levels of adamantane resistance among influenza A (H3N2) viruses and interim guidelines for use of antiviral agents- ...
Donepezil
There is no evidence that donepezil or other similar agents alters the course or progression of Alzheimer's disease. Six-to- ... People with peptic ulcer disease or taking NSAIDS should use with caution because increased risk of gastrointestinal bleeding ... is a centrally acting reversible acetylcholinesterase inhibitor and structurally unrelated to other anticholinesterase agents.[ ...
Antiemetic
5-HT3 receptor antagonists block serotonin receptors in the central nervous system and gastrointestinal tract. As such, they ... Cannabinoids are used in patients with cachexia, cytotoxic nausea, and vomiting, or who are unresponsive to other agents. These ...
Domperidone
... motility disorders and to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents ... Kapoor, A.K.; Raju, S.M. (2013). "7.2 Gastrointestinal Drugs". Illustrated Medical Pharmacology. JP Medical Ltd. p. 677. ISBN ... Poor gastrointestinal function, nausea and vomiting is a major problem for people with Parkinson's disease because most ... Suzanne Rose (October 2004). Gastrointestinal and Hepatobiliary Pathophysiology. Hayes Barton Press. pp. 523-. ISBN 978-1-59377 ...
Succinic semialdehyde dehydrogenase deficiency
This agent can eventually compromise the pathways of fatty acid, glycine, and pyruvate metabolism, and then become detectable ... Gastrointestinal symptoms have been seen primarily in this population and are usually related to increased feeding. ... The most common therapeutic agent available for SSADH deficiency is one that reduces the levels of GHB via inhibition of GABA ...
Mercury Toxicity Medication: Chelating Agents, Gastrointestinal Decontaminants
... gastrointestinal (GI) and renal organ systems. Poisoning can result from mercury vapor inhalation, mercury ingestion, mercury ... Gastrointestinal Decontaminants. Class Summary. These agents are empirically used to minimize systemic absorption of the toxin ... Chelating Agents. Class Summary. These agents are used to help remove a portion of the bodys mercury stores. They are ... Because of this agents ease of use, good efficacy, and safety, initiate treatment with DMSA if good evidence indicates that ...
Gastrointestinal Agents
Search of: 'Neuromyelitis Optica Spectrum Disorder' | 'Gastrointestinal Agents' - List Results - ClinicalTrials.gov
Beta-Blocker Toxicity Medication: Gastrointestinal Tract Decontaminants, Cardiovascular agents, Benzodiazepines,...
Gastrointestinal Tract Decontaminants. Class Summary. These agents are used to minimize the absorption of ingested compound. ... Cardiovascular agents. Class Summary. These agents are used for symptomatic bradycardia and/or hypotension. Catecholamines are ... Agents with combined alpha- and beta-selective properties may be necessary to maintain blood pressure. A beta-agonist may ... Agents with combined alpha- and beta-selective properties may be necessary to maintain blood pressure. A beta-agonist may ...
What is VPRIV? | Gastrointestinal Agent - Sharecare
Gastrointestinal agents
What are the brand names for atropine? | Gastrointestinal Agent - Sharecare
Gastrointestinal agents | definition of Gastrointestinal agents by Medical dictionary
What is Gastrointestinal agents? Meaning of Gastrointestinal agents medical term. What does Gastrointestinal agents mean? ... Looking for online definition of Gastrointestinal agents in the Medical Dictionary? Gastrointestinal agents explanation free. ... gastrointestinal tract. (redirected from Gastrointestinal agents). Also found in: Dictionary, Thesaurus, Encyclopedia. tract. [ ... Gastrointestinal agents , definition of Gastrointestinal agents by Medical dictionary https://medical-dictionary. ...
Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft - Full...
Anti-Ulcer Agents. Gastrointestinal Agents. Enzyme Inhibitors. Molecular Mechanisms of Pharmacological Action. ... Gastric Ulcer Induced by Antiplatelet Agent Ulcer of the Gastrointestinal Tract Proton Pump Inhibitor Drug: Pantoprazole Phase ... Proton Pump Inhibitor Prevent Dual Antiplatelet Agents Induced Gastrointestinal Ulcer After Coronary Artery Bypass Graft (DACAB ... Gastrointestinal Diseases. Digestive System Diseases. Stomach Diseases. Pantoprazole. Proton Pump Inhibitors. ...
Cells | Free Full-Text | Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac
So, the aim of this work is to study the effect of MLT as preventive agent of GI injury caused by NSAIDs. With this objective ... Now there are evidences of the involvement of multiple cellular pathways in the NSAIDs-mediated-gastrointestinal (GI) damage ... Therefore, we found that MLT may be a preventive agent of GI damages induced by NSAIDs. ... Study of Melatonin as Preventive Agent of Gastrointestinal Damage Induced by Sodium Diclofenac by Aroha B. Sánchez 1, Beatriz ...
When Should Antiplatelet Agents and Anticoagulants Be Restarted after Gastrointestinal Bleed? | The Hospitalist
Resumption of Antiplatelet Agents. The decision to resume antiplatelet therapy should also be highly individualized. In ... Gastrointestinal (GI) bleeding is a serious complication of anticoagulant and antiplatelet therapy. Risks for GI bleeding ... Gastrointestinal bleeding in the setting of anticoagulation and antiplatelet therapy. J Clin Gastroenterol. 2009;43(1):5-12. ... Given the lack of reversing agents for these drugs, we recommend exercising caution in populations with a high risk of ...
Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future...
Imatinib is strongly positioned as the recommended first-line agent for most patients with advanced gastrointestinal stromal ... Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future ... 2 Approved Agents. 2.1 Imatinib. Imatinib has been considered the standard first-line agent since its approval in 2002. It is ... Imatinib is strongly positioned as the recommended first-line agent for most patients with advanced gastrointestinal stromal ...
Hydrogen Sulfide: An Agent of Stability at the Microbiome-Mucosa Interface | Gastrointestinal and Liver Physiology
Hydrogen Sulfide: An Agent of Stability at the Microbiome-Mucosa Interface. John L Wallace, Jean-Paul Motta, Andre G Buret ... Hydrogen Sulfide: An Agent of Stability at the Microbiome-Mucosa Interface Message Subject (Your Name) has forwarded a page to ... American Journal of Physiology - Gastrointestinal and Liver Physiology Published 12 October 2017 Vol. no. , DOI: 10.1152/ajpgi. ... H2S donors can modify the gut microbiota and the gastrointestinal epithelium is a major site of oxidation of microbial-derived ...
Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine | Gastrointestinal and...
American Journal of Physiology - Gastrointestinal and Liver Physiology Published 1 June 1999 Vol. 276 no. 6, G1408-G1416 DOI: ... 1 and Tables3-5). All three constrictor agents, i.e., ANG II, NE, and ET-1, caused a significantly greater peak level and ... Effects of sustained low-flow perfusion on the response to vasoconstrictor agents in postnatal intestine. Philip T. Nowicki ... A significant leftward shift in the dose-response curve was observed for all three constrictor agents (Fig. 3). The calculated ...
Current practice in managing patients on anticoagulants and/or antiplatelet agents around the time of gastrointestinal...
Gastrointestinal bleeding is a well-known complication of these agents. Modification of anticoagulant and antiplat ... Anticoagulants and antiplatelet agents are widely used in the prophylaxis and management of thromboembolic and cardiovascular ... Gastrointestinal bleeding is a well-known complication of these agents. Modification of anticoagulant and antiplatelet therapy ... Current practice in managing patients on anticoagulants and/or antiplatelet agents around the time of gastrointestinal ...
Differential Susceptibilities to Azithromycin Treatment of Chlamydial Infection in the Gastrointestinal Tract and Cervix |...
Antimicrobial Agents and Chemotherapy Nov 2013, 57 (12) 6290-6294; DOI: 10.1128/AAC.01405-13 ... Antimicrobial Agents and Chemotherapy Nov 2013, 57 (12) 6290-6294; DOI: 10.1128/AAC.01405-13 ... A new animal model for the study of Chlamydia trachomatis genital infections: infection of mice with the agent of mouse ... Thank you for sharing this Antimicrobial Agents and Chemotherapy article.. NOTE: We request your email address only to inform ...
A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal...
A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal ... A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal ... A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal ... A Phase I Study of Single-Agent Nilotinib or in Combination with Imatinib in Patients with Imatinib-Resistant Gastrointestinal ...
Gastrointestinal dysfunction and enteric neurotoxicity following treatment with anticancer chemotherapeutic agent 5...
Gastrointestinal transit was analysed in vivo prior to and following 3, 7, and 14 days of 5-FU treatment via serial x-ray ... Long-term treatment (7, 14 days) resulted in delayed gastrointestinal transit, inhibition of colonic migrating motor complexes ... KEY RESULTS Short-term administration of 5-FU (3 days) increased gastrointestinal transit, induced acute intestinal ... CONCLUSIONS & INFERENCES Our results indicate that 5-FU induces accelerated gastrointestinal transit associated with acute ...
Recent advances and novel agents for gastrointestinal stromal tumor (GIST) | Journal of Hematology & Oncology | Full Text
The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. Other spindle cell ... A phase I study of single-agent nilotinib or in combination with imatinib in patients with imatinib-resistant gastrointestinal ... Novel agents. mTOR inhibitors. Novel approaches to overcome resistance to TKIs in GIST include targeting multiple levels of the ... Based on these data, this agent was approved for treatment of GIST following failure of imatinib in January 2006.. Table 1 TKIs ...
Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. -...
Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers.. @ ... article{Poen1999EffectOP, title={Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal ... Pharmacologic , Pharmacokinetic , and Pharmacogenomic Aspects of Functional Gastrointestinal Disorders. *Michael Camilleri, ...
Gastrointestinal Agents Market Size, Share And Forecast To 2025
Gastrointestinal Agents Market Was Valued At US$ 17,255.3 Mn In 2016, And Is Expected To Reach US$ 21,177.7 Mn By 2025, ... 2.3 Global Gastrointestinal Agents Market Revenue, by Geography, 2016 (US$ Million). Chapter 3 Global Gastrointestinal Agents ... TABLE 8 Global Gastrointestinal Agents Market, by Region, 2015 - 2025 (US$ Mn). TABLE 9 North America Gastrointestinal Agents ... TABLE 10 Europe Gastrointestinal Agents, by Country, 2015 - 2025 (US$ Mn). TABLE 11 Asia Pacific Gastrointestinal Agents, by ...
Oklahoma State and Education Employees Group Insurance Board - Searchable Medicare Supplement
Gastrointestinal Agents. Treat rheumatoid arthritis, Crohns Disease, or ulcerative colitis. REMICADE (infliximab) ... Sedative-Hypnotic Agents. Treat insomnia or sleeping disorders. AMBIEN (zolpidem), AMBIEN CR (zolpidem), BUTISOL (butabarbital ... Erectile Dysfunction/Impotence Agents. Treat male impotence. CIALIS (tadalafil), CAVERJECT, EDEX (alprostadil inj), LEVITRA ( ... Respiratory Agents. Treat special bronchial-related disease states. PULMOZYME (recombinant dornase alfa inhalation solution), ...
JoDrugs. Gastrointestinal Agent
Noxafil (Posaconazole Oral Suspension): Side Effects, Interactions, Warning, Dosage & Uses
Gastrointestinal Motility Agents. Posaconazole Delayed-Release Tablet. Concomitant administration of metoclopramide with ... 400-mg single dose with a prokinetic agent (metoclopramide 10 mg TID for 2 days) + BOOST or an antikinetic agent (loperamide 4- ... Posaconazole is an azole antifungal agent [see Microbiology].. Pharmacodynamics. Exposure Response Relationship. In clinical ... Noxafil is an azole antifungal agent available as concentrated solution to be diluted before intravenous administration, ...
Onmel (Itraconazole Oral Administration): Uses, Dosage, Side Effects, Interactions, Warning
Gastrointestinal Motility Agents. cisapride. HMG CoA-Reductase Inhibitors. atorvastatin, cerivastatin, lovastatin, simvastatin ... Gastrointestinal Motility Agents. Co-administration of itraconazole with cisapride can elevate plasma cisapride concentrations ... Oral Hypoglycemic Agents. Severe hypoglycemia has been reported in patients concomitantly receiving azole antifungal agents and ... Gastrointestinal disorders:. Abdominal pain, vomiting, dyspepsia, nausea, diarrhea, constipation, dysgeusia. Hepato-biliary ...
Drug Dosing in Chronic Kidney Disease
Precautions: Gastrointestinal Agents *Avoid phosphate and Magnesium containing Laxatives or enemas. *Avoid Magnesium containing ... Agents to avoid at any level of CRF or risk of CRF. *NSAIDS (repeat Serum Creatinine q2 weeks if used) ... Agents to avoid in severe CRF (GFR ,30 ml/min) that are typically avoided for other risks (listed for historical reasons). * ... Preferred agents in CRF (renal and cardioprotective). *Starting dose. *Moderate dose in most patients (e.g. Lisinopril 10-20 mg ...
Medications that Delay Gastric Emptying
Risamal
-
Gastrointestinal Agents, Anti-ulcer Agents, Prokinetic Agents, Serotonin Agonists, ATC:A03FA02
Chitosan in Animal Health - Gastro Intestinal Diseases, Antimicrobial agent
... , Chitosan Derivatives, Chitosan Agriculture ... Chitosan in Animal Health - Gastro Intestinal Diseases, Antimicrobial agent Dietary supplementation of chitosan & chitosan ... Description : Chitosan Nanoparticles are useful as antibacterial agents. Chitosan nano particles are widely used f... ...
Natural oral contrast agents for gastrointestinal magnetic resonance imaging - Virtual Health Sciences Library
Natural oral contrast agents for gastrointestinal magnetic resonance imaging Assiut Univ. Bull. Environ. Res. 2015; 2 (4): 200- ... Oral contrast agents can be the artificial materials or natural factors. Natural contrast agents consist of fruit juice or ... We briefly reviewed the different types of contrast agents and focused on the studies in which natural oral contrast agents ... Some advantages have been reported regarding the natural types of contrast agents over the artificial agents including better ...
TractImatinib-Resistant Gastrointestinal Stromal TumorsStromal TumorsEndoscopyMotilityAntiplatelet agentsChemotherapyTherapeuticJournal of PhysiologyPhysiologyDisordersAntipsychotic AgentsGISTToxicityCardiovascularMedicationsDiseasesEpitheliumClinicalPepticCorticosteroidsNSAIDsPatientsTherapyPharmaceuticalsSingle-agent nilotinibPoisoning2017Anti-infectiveHormonesNauseaInhibitsConstipationRespiratoryIntestineEndoscopicAntifungalAcidErectileRenalSymptomsDiseaseTransitDoses
Tract14
- a radiological examination of the upper gastrointestinal tract using barium as the contrast medium for a series of x-ray films. (thefreedictionary.com)
- Hydrogen sulfide is produced gastrointestinal tract tissues and by bacteria residing within the gut, and can influence the function of a wide range of cells. (physiology.org)
- Evidence from animal studies suggests that chlamydiae may persist in the gastrointestinal tract (GI) and be a reservoir for reinfection of the genital tract. (asm.org)
- Alternatively, it is possible that women become autoinfected from the gastrointestinal (GI) tract. (asm.org)
- Thus, we have proposed that chlamydiae can persist in the gastrointestinal tract and that women can be reinfected in the genital tract by autoinfection from the rectum. (asm.org)
- Cisapride stimulates motility of the upper gastrointestinal tract without stimulating gastric, biliary, or pancreatic secretions. (pharmacycode.com)
- Unfortunately, these compounds are equally capable of inhibiting constitutively expressed COX-1 in tissues such as the gastrointestinal tract and kidney, which results in serious, mechanism-based toxicities that limit the drug's therapeutic utility. (wustl.edu)
- Masferrer, JL, Isakson, PC & Seibert, K 1996, ' Cyclooxygenase-2 inhibitors: A new class of anti-inflammatory agents that spare the gastrointestinal tract ', Gastroenterology Clinics of North America , vol. 25, no. 2, pp. 363-372. (wustl.edu)
- Lafutidine is a generic antihistamine drug which is used to treat diseases involving the gastrointestinal tract such as oesophagus. (tradeindia.com)
- An Update on the Role of Immunohistochemistry in the Evaluation of Gastrointestinal Tract Disorders. (bioportfolio.com)
- Gastrointestinal stromal tumors (GISTs) are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. (bioportfolio.com)
- To evaluate the diagnostic yield of the cell block (CB) technique with immunohistochemistry in patients with mesenchymal neoplasms of the gastrointestinal tract collected by endoscopic ultrasound-guid. (bioportfolio.com)
- It has been used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract. (bioportfolio.com)
- Gastrointestinal and urinary tract stimulants. (worldcat.org)
Imatinib-Resistant Gastrointestinal Stromal Tumors1
- To study the safety, tolerability, and pharmacokinetics of the selective tyrosine kinase inhibitor nilotinib as a single agent or in combination with imatinib in patients with advanced imatinib-resistant gastrointestinal stromal tumors. (aacrjournals.org)
Stromal Tumors4
- The discovery of CD117 mutation in almost all gastrointestinal stromal tumors (GISTs) marked a milestone. (biomedcentral.com)
- EPIGIST: An observational real-life study on patients with metastatic gastrointestinal stromal tumors receiving imatinib. (bioportfolio.com)
- Retrospective evaluation of toceranib phosphate (Palladia®) use in the treatment of gastrointestinal stromal tumors of dogs. (bioportfolio.com)
- Gastrointestinal stromal tumors (GISTs) are uncommon intestinal neoplasms in the dog. (bioportfolio.com)
Endoscopy4
- Current practice in managing patients on anticoagulants and/or antiplatelet agents around the time of gastrointestinal endoscopy -- a nation-wide survey in Germany. (biomedsearch.com)
- A survey of the American Society for Gastrointestinal Endoscopy (ASGE), performed several years ago, showed a wide variation between endoscopists in the management of anticoagulants and antiplatelet agents in the periendoscopic period. (biomedsearch.com)
- Periprocedural management of antithrombotics for gastrointestinal endoscopy is a common clinical issue, given the widespread use of these drugs for primary and secondary cardiovascular prevention. (annalsgastro.gr)
- Upper gastrointestinal bleeding is the leading emergency leading to hospitalization and urgent endoscopy. (google.com)
Motility3
- TRPV4 Channel Signaling in Macrophages Promotes Gastrointestinal Motility via Direct Effects on Smooth Muscle Cells. (semanticscholar.org)
- X-ray analysis of gastrointestinal motility in conscious mice. (semanticscholar.org)
- Antidiarrheal agents == '''Antidiarrheal agents''' include bulk forming agents, hydroscopic agents, bile acid resins, [[bismuth]], inhibitors of intestinal motility, non-absorbed antibiotics and hormones. (wikimd.org)
Antiplatelet agents5
- When Should Antiplatelet Agents and Anticoagulants Be Restarted after Gastrointestinal Bleed? (the-hospitalist.org)
- The decision to restart antiplatelet agents and/or anticoagulants should involve a patient-specific approach regarding potential risks and benefits. (the-hospitalist.org)
- Although there is consensus on ceasing anticoagulant and antiplatelet agents during an acute GI bleed, debate remains over the appropriate approach to restarting these agents. (the-hospitalist.org)
- Anticoagulants and antiplatelet agents are widely used in the prophylaxis and management of thromboembolic and cardiovascular diseases. (biomedsearch.com)
- Our data demonstrate that, in spite of the dissemination of guidelines, there is still a wide variation in the periendoscopic management of patients who are at increased risk for bleeding due to anticoagulants, especially in patients taking antiplatelet agents. (biomedsearch.com)
Chemotherapy4
- Conventional chemotherapy agents have little activity against GIST. (springer.com)
- Impact of chemotherapy on gastrointestinal functions and the enteric nervous system. (semanticscholar.org)
- Platinum-based chemotherapy: gastrointestinal immunomodulation and enteric nervous system toxicity. (semanticscholar.org)
- The purpose of this study is to define the recommended dose of BMS-582664 that could be safely combined with 5-fluorouracil, leucovorin, and irinotecan (FOLFIRI) or 5-fluorouracil, leucovorin, and oxaliplatin (FOLFOX) chemotherapy regimens in patients with advanced gastrointestinal malignancies and to evaluate the safety profile, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of these combinations. (bioportfolio.com)
Therapeutic11
- In a preferred embodiment, said nanoparticle contains a diagnostic or therapeutic agent therein. (google.com)
- 1. A composition comprised of nanoparticles consisting essentially of 99.9-10% by weight of an organic crystalline therapeutic or diagnostic agent having tyloxapol adsorbed on the surface thereof in an amount of 0.1-90% by weight and sufficient to maintain an average particle size of less than 400 nm. (google.com)
- and an additional surface modifier associated therewith, said method comprising contacting said therapeutic or diagnostic agent with tyloxapol for a time and under conditions sufficient to provide a nanoparticle-tyloxapol composition. (google.com)
- Some commonly used pesticides (for example, the organophosphate (OP) Malathion and the carbamate Sevin) and some common therapeutic drugs (the carbamates pyridostigmine [Mestinon] and physostigmine [Antilirium]) also inhibit acetylcholinesterase and can be considered 'nerve agents. (fas.org)
- Providing both understanding and guidance in characterizing potential drugs and their production and synthesis, Development of Therapeutic Agents Handbook gives professionals a basic tool to facilitate research and development within this challenging process. (wiley.com)
- This comprehensive text brings together, in one resource, a compendium of concepts, approaches, methodologies, and limitations that need to be considered in the formulation of therapeutic agents across a range of therapeutic fields. (wiley.com)
- Both a reference and a call to action for the pharmaceutical industry, Development of Therapeutic Agents Handbook examines recent innovations taking shape in the various medical disciplines involved in drug discovery, and shows why these advances need to be embraced universally among researchers to improve their solution strategies. (wiley.com)
- Development of Therapeutic Agents Handbook serves this purpose, acting as both a one-stop reference rich in valid science, and a tool to carve out new pathways in the pursuit of bringing safer and more effective drugs to the marketplace. (wiley.com)
- Many drugs used in the treatment of psychotic disorders (ANTIPSYCHOTIC AGENTS) are dopamine antagonists, although their therapeutic effects may be due to long-term adjustments of the brain rather than to the acute effects of blocking dopamine receptors. (nih.gov)
- A major objective for the clinical evaluation of mAbs has been determining the toxicity and therapeutic efficacy of the antibody alone or as a delivery system for radioisotopes or other toxic agents. (nature.com)
- Active ingredients of central nervous system agents will remain the largest therapeutic group served by pharmaceutical chemicals based on value and will post above average revenue growth. (freedoniagroup.com)
Journal of Physiology1
- American Journal of Physiology - Gastrointestinal and Liver Physiology Published 12 October 2017 Vol. no. (physiology.org)
Physiology2
- Thank you for your interest in spreading the word about Gastrointestinal and Liver Physiology. (physiology.org)
- Message Body (Your Name) thought you would like to see this page from the Gastrointestinal and Liver Physiology web site. (physiology.org)
Disorders4
- Regional differences in the manifestation of gastrointestinal motor disorders in type 1 diabetic pat. (biomedsearch.com)
- Thus rise in chronic gastrointestinal disorders and diseases, along with availability of OTC drugs are driving the growth of gastrointestinal drugs market. (credenceresearch.com)
- Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and it is characterized by episodes of abdominal pain and altered bowel functions. (mendeley.com)
- 5. Gastrointestinal agents: Agents used to treat acid peptic disorders. (worldcat.org)
Antipsychotic Agents2
- Chlorpromazine was approved for use in the United States in 1957 and was formerly the most commonly prescribed antipsychotic medication, being the prototypic, standard neuroleptic agent against which other antipsychotic agents were tested. (nih.gov)
- Antipsychotic agents. (worldcat.org)
GIST7
- Imatinib is strongly positioned as the recommended first-line agent for most patients with advanced gastrointestinal stromal tumor (GIST) due to its good efficacy and tolerability. (springer.com)
- Sunitinib and regorafenib are approved as second- and third-line agents, respectively, for patients whose GIST does not respond to imatinib or who do not tolerate imatinib, and their use is supported by large randomized trials. (springer.com)
- Besides ATP-mimetic tyrosine kinase inhibitors many other agents with a different mechanism of action are efficacious in the treatment of patients with advanced GIST. (springer.com)
- Concomitant or sequential administration of agents with different mechanisms of action may become a novel approach to treat advanced GIST. (springer.com)
- We review here the experimental agents studied to treat imatinib-resistant advanced GIST. (springer.com)
- In this review, we discuss the highlights of recent advances and novel agents for GIST therapy. (biomedcentral.com)
- Remarkable developments have occurred in gastrointestinal stromal tumor (GIST) research and clinical care in the past several years. (biomedcentral.com)
Toxicity2
- As previously discussed, 2,3-dimercaptosuccinic acid (DMSA) and N -acetyl-D,L-penicillamine have been used as chelating agents in the treatment of mercury toxicity. (medscape.com)
- Aim: The relative gastrointestinal toxicity of NSAIDs in normal clinical practice is unknown. (uab.cat)
Cardiovascular1
- Oral contraceptives, hormone therapy, some psychotropic drugs, and some cardiovascular agents have been associated with mastalgia. (aafp.org)
Medications3
- These agents are some of the most commonly taken medications and are very well tolerated, most being available both by prescription and over-the-counter. (wikimd.org)
- Gastrointestinal medications and breastfeeding. (drugs.com)
- Patients should be evaluated for potential interactions between antiretrovirals and concurrent medications (including over-the-counter agents). (aafp.org)
Diseases1
- Overestimating the occurrence of foodborne diseases caused by unknown agents may lead us to undervalue the public health importance of these and other well-known agents. (cdc.gov)
Epithelium1
- H 2 S donors can modify the gut microbiota and the gastrointestinal epithelium is a major site of oxidation of microbial-derived H 2 S. When administered together with nonsteroidal anti-inflammatory drugs, H 2 S can prevent some of the dysbiosis those drugs induce, possibly contributing to the observed prevention of gastrointestinal damage. (physiology.org)
Clinical5
- These agents prevent seizure recurrence and terminate clinical and electrical seizure activity. (medscape.com)
- Agents that have been found promising in preclinical models and early clinical trials include small molecule KIT and PDGFRA mutation-specific inhibitors, heat shock protein inhibitors, histone deacetylase inhibitors, allosteric KIT inhibitors, KIT and PDGFRA signaling pathway inhibitors, and immunological approaches including antibody-drug conjugates. (springer.com)
- Nilotinib alone or in combination with imatinib was well tolerated overall and showed clinical activity in imatinib-resistant gastrointestinal stromal tumor patients. (aacrjournals.org)
- The clinical effects from nerve agent exposure are caused by excess acetylcholine. (fas.org)
- Note: The actual clinical manifestations of an exposure to a nerve agent or an organophosphate pesticide may be more variable than the syndrome described in this document. (cdc.gov)
Peptic1
- The risk was significantly increased in patients with a history of peptic ulcer and/or upper gastrointestinal bleeding, and in those taking antiplatelet drugs. (uab.cat)
Corticosteroids1
- 7. Hormones and agents affecting hormonal mechanisms: Adrenal corticosteroids. (worldcat.org)
NSAIDs5
- Now there are evidences of the involvement of multiple cellular pathways in the NSAIDs-mediated-gastrointestinal (GI) damage related to enterocyte redox state. (mdpi.com)
- So, the aim of this work is to study the effect of MLT as preventive agent of GI injury caused by NSAIDs. (mdpi.com)
- Therefore, we found that MLT may be a preventive agent of GI damages induced by NSAIDs. (mdpi.com)
- The aim of this study was to estimate the risk of upper gastrointestinal bleeding associated with NSAIDs and analgesics, with special emphasis on those agents that have been introduced in recent years. (uab.cat)
- NSAIDs are potent anti-inflammatory and analgesic agents. (wustl.edu)
Patients8
- A phase I intercohort dose-escalation trial was done in patients who received either ( a ) single agent nilotinib 400 mg twice daily or ( b ) escalating doses of nilotinib (200 mg once daily, 400 mg qd, or 400 mg bid) plus imatinib 400 mg bid (10- and 14-hour interval daily), or ( c ) nilotinib 400 mg bid plus imatinib 400 mg qd. (aacrjournals.org)
- Conversely, bridging therapy is usually not needed for patients taking new oral agents, which are characterized by shorter half-lives, and a rapid offset and onset of action. (annalsgastro.gr)
- In the present article we review publications reporting on phase 2 and phase 3 studies evaluating agents to potentially be used in the treatment of patients with IBS. (mendeley.com)
- In kidney, liver, and heart transplant patients, cyclosporine [MODIFIED] may be administered with other immunosuppressive agents. (nih.gov)
- Psoriasis patients previously treated with PUVA and to a lesser extent, methotrexate or other immunosuppressive agents, UVB, coal tar, or radiation therapy, are at an increased risk of developing skin malignancies when taking cyclosporine [MODIFIED]. (nih.gov)
- The epidemiology is changing with more complex older patients on anticoagulant and antithrombotic agents presenting with upper gastrointestinal bleeding. (google.com)
- In order to give optimal care to patients, it is critical that practicing gastroenterologists are aware of the many recent advances in management of patients with upper gastrointestinal bleeding. (google.com)
- Prezista is specifically indicated for the treatment of HIV-1 infections in combination with ritonavir and other antiviral agents in treatment-experienced patients, including patients who have failed prior courses of treatment with other PIs. (centerwatch.com)
Therapy5
- Gastrointestinal (GI) bleeding is a serious complication of anticoagulant and antiplatelet therapy. (the-hospitalist.org)
- For cases where the short-term benefit of anticoagulant or antiplatelet therapy outweighs the immediate risk, the appropriate agent can be restarted within four to five days of achieving hemostasis. (the-hospitalist.org)
- Tybost is indicated as a boosting agent for the HIV protease inhibitors atazanavir 300 mg once daily and darunavir 800 mg once daily as part of antiretroviral combination therapy in adults with HIV-1 infection. (gilead.com)
- The attachment of the agent to the enzyme is permanent (unless removed by therapy). (fas.org)
- However, while the OP pesticides cause the same biological effects as nerve agents, there are some important differences in the duration of biological activity and response to therapy. (fas.org)
Pharmaceuticals1
- Home » Products » Pharmaceuticals and Biochemicals » Gastrointestinal agents In total 717051 number ofProductsinfo,Released today. (freedomlist.com)
Single-agent nilotinib1
- This phase I trial identified single-agent nilotinib 400 mg bid or combined with imatinib 400 mg qd as possible phase II doses for further evaluation. (aacrjournals.org)
Poisoning1
- For example, inhalation of a nerve agent or an OP pesticide leads to a quicker onset of poisoning with more severe symptoms when compared to with dermal exposure s, given the same amount of agent. (cdc.gov)
20171
- The report titled "Gastrointestinal Agents Market - Growth, Future Prospects and Competitive Analysis, 2017-2025" offers strategic insights into the overall gastrointestinal agents market along with the market size and estimates for the duration 2015 to 2025. (credenceresearch.com)
Anti-infective1
- They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (nih.gov)
Hormones1
- Led by active ingredients of anticancer, antidiabetic, and hormone replacement formulations, hormones and related agents will post the fastest growth in value among all pharmaceutical chemicals. (freedoniagroup.com)
Nausea1
- Gastrointestinal drugs treat nausea, diarrhea, and ulcers. (sharecare.com)
Inhibits1
- After a nerve agent inhibits the tissue enzyme, the enzyme cannot hydrolyze acetylcholine, the neurotransmitter at cholinergic receptor sites. (fas.org)
Constipation2
- Gastrointestinal-May cause or worsen pre-existing constipation. (webmd.com)
- Diarrhea/constipation A. ETIOLOGIC AGENT 5. (slideshare.net)
Respiratory1
- immunological agents and respiratory systems among others. (bioportfolio.com)
Intestine1
- Most antidiarrheal agents are active locally in the small intestine and colon and are largely not absorbed. (wikimd.org)
Endoscopic1
- Fewer data exist with regard to the use of these agents around the time of endoscopic procedures. (biomedsearch.com)
Antifungal4
- Noxafil is an azole antifungal agent available as concentrated solution to be diluted before intravenous administration, delayed-release tablet, or suspension for oral administration. (rxlist.com)
- ONMEL (itraconazole) is a synthetic triazole antifungal agent for oral use. (rxlist.com)
- Antifungal agents. (worldcat.org)
- SPORANOX® is the brand name for itraconazole, a synthetic triazole antifungal agent. (globalrph.com)
Acid1
- These agents help in relieving gastrointestinal acid reflux. (medscape.com)
Erectile1
- Erectile dysfunction agent. (worldcat.org)
Renal1
- 6. Cardiac, vascular, and renal agents: Agents used to treat migraine. (worldcat.org)
Symptoms2
- The likely presenting symptoms would be _ because most infectious agents are distributed in _ form, but _ outbreaks through _ could also occur. (brainscape.com)
- The following is a more comprehensive list of signs and symptoms that may be encountered in a person exposed to a nerve agent or OP pesticide. (cdc.gov)
Disease3
- In this study scope, gastrointestinal disease or disorder includes gastroesophageal reflux disease (GERD), irritable bowel syndrome (IBS) and inflammatory bowel disease (IBD). (credenceresearch.com)
- Even though "accurate estimates of disease burden are the foundation of sound public health policy" (2) , most of these estimates (in particular, the assumption that unknown agents are transmitted by food in the same proportion as known agents) were derived from assumptions rather than data. (cdc.gov)
- If eradicating Campylobacter , Salmonella, Escherichia coli O157:H7, and Listeria would reduce the number of foodborne illnesses by only 5%, hospitalizations by 10%, and deaths by 25%, why are these agents the primary focus of our national foodborne disease control efforts? (cdc.gov)
Transit1
- Effect of prucalopride, a new enterokinetic agent, on gastrointestinal transit and anorectal function in healthy volunteers. (semanticscholar.org)
Doses1
- Although most useful if administered within 4 hours of ingestion, repeated doses may be used, especially with ingestions of sustained-released agents. (medscape.com)