Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
Lining of the ORAL CAVITY, including mucosa on the GUMS; the PALATE; the LIP; the CHEEK; floor of the mouth; and other structures. The mucosa is generally a nonkeratinized stratified squamous EPITHELIUM covering muscle, bone, or glands but can show varying degree of keratinization at specific locations.
Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Parietal Cells, Gastric
Proenzymes secreted by chief cells, mucous neck cells, and pyloric gland cells, which are converted into pepsin in the presence of gastric acid or pepsin itself. (Dorland, 28th ed) In humans there are 2 related pepsinogen systems: PEPSINOGEN A (formerly pepsinogen I or pepsinogen) and PEPSINOGEN C (formerly pepsinogen II or progastricsin). Pepsinogen B is the name of a pepsinogen from pigs.
An EPITHELIUM with MUCUS-secreting cells, such as GOBLET CELLS. It forms the lining of many body cavities, such as the DIGESTIVE TRACT, the RESPIRATORY TRACT, and the reproductive tract. Mucosa, rich in blood and lymph vessels, comprises an inner epithelium, a middle layer (lamina propria) of loose CONNECTIVE TISSUE, and an outer layer (muscularis mucosae) of SMOOTH MUSCLE CELLS that separates the mucosa from submucosa.
A clear, colorless liquid rapidly absorbed from the gastrointestinal tract and distributed throughout the body. It has bactericidal activity and is used often as a topical disinfectant. It is widely used as a solvent and preservative in pharmaceutical preparations as well as serving as the primary ingredient in ALCOHOLIC BEVERAGES.
Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).
Formed from pig pepsinogen by cleavage of one peptide bond. The enzyme is a single polypeptide chain and is inhibited by methyl 2-diaazoacetamidohexanoate. It cleaves peptides preferentially at the carbonyl linkages of phenylalanine or leucine and acts as the principal digestive enzyme of gastric juice.
Prostaglandins E, Synthetic
Chief Cells, Gastric
Anti-Inflammatory Agents, Non-Steroidal
Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.
Rats, Inbred Strains
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
The prototypical analgesic used in the treatment of mild to moderate pain. It has anti-inflammatory and antipyretic properties and acts as an inhibitor of cyclooxygenase which results in the inhibition of the biosynthesis of prostaglandins. Aspirin also inhibits platelet aggregation and is used in the prevention of arterial and venous thrombosis. (From Martindale, The Extra Pharmacopoeia, 30th ed, p5)
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
A condition with damage to the lining of the lower ESOPHAGUS resulting from chronic acid reflux (ESOPHAGITIS, REFLUX). Through the process of metaplasia, the squamous cells are replaced by a columnar epithelium with cells resembling those of the INTESTINE or the salmon-pink mucosa of the STOMACH. Barrett's columnar epithelium is a marker for severe reflux and precursor to ADENOCARCINOMA of the esophagus.
Histamine H2 Antagonists
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
Lewis Blood-Group System
A group of dominantly and independently inherited antigens associated with the ABO blood factors. They are glycolipids present in plasma and secretions that may adhere to the erythrocytes. The phenotype Le(b) is the result of the interaction of the Le gene Le(a) with the genes for the ABO blood groups.
Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).
I Blood-Group System
Sodium Pertechnetate Tc 99m
(11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.
Reverse Transcriptase Polymerase Chain Reaction
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)
A megaloblastic anemia occurring in children but more commonly in later life, characterized by histamine-fast achlorhydria, in which the laboratory and clinical manifestations are based on malabsorption of vitamin B 12 due to a failure of the gastric mucosa to secrete adequate and potent intrinsic factor. (Dorland, 27th ed)
Periodic Acid-Schiff Reaction
A 28-amino acid, acylated, orexigenic peptide that is a ligand for GROWTH HORMONE SECRETAGOGUE RECEPTORS. Ghrelin is widely expressed but primarily in the stomach in the adults. Ghrelin acts centrally to stimulate growth hormone secretion and food intake, and peripherally to regulate energy homeostasis. Its large precursor protein, known as appetite-regulating hormone or motilin-related peptide, contains ghrelin and obestatin.
Procedures of applying ENDOSCOPES for disease diagnosis and treatment. Endoscopy involves passing an optical instrument through a small incision in the skin i.e., percutaneous; or through a natural orifice and along natural body pathways such as the digestive tract; and/or through an incision in the wall of a tubular structure or organ, i.e. transluminal, to examine or perform surgery on the interior parts of the body.
ABO Blood-Group System
The major human blood type system which depends on the presence or absence of two antigens A and B. Type O occurs when neither A nor B is present and AB when both are present. A and B are genetic factors that determine the presence of enzymes for the synthesis of certain glycoproteins mainly in the red cell membrane.
The vital life force in the body, supposedly able to be regulated by acupuncture. It corresponds roughly to the Greek pneuma, the Latin spiritus, and the ancient Indian prana. The concept of life-breath or vital energy was formulated as an indication of the awareness of man, originally directed externally toward nature or society but later turned inward to the self or life within. (From Comparison between Concepts of Life-Breath in East and West, 15th International Symposium on the Comparative History of Medicine - East and West, August 26-September 3, 1990, Shizuoka, Japan, pp. ix-x)
The amount of a substance secreted by cells or by a specific organ or organism over a given period of time; usually applies to those substances which are formed by glandular tissues and are released by them into biological fluids, e.g., secretory rate of corticosteroids by the adrenal cortex, secretory rate of gastric acid by the gastric mucosa.
Effect of paracetamol (acetaminophen) on gastric ionic fluxes and potential difference in man. (1/4985)Paracetamol has replaced aspirin as the analgesic of choice in many situations. The major reason is the damaging effect of aspirin on gastric mucosa. Alterations in gastric ionic fluxes and potential difference provide measures of aspirin-induced structural damage. We studied the effect of large doses of paracetamol (acetaminophen 2-0 g) on gastric ionic fluxes in man. In addition, the effect of 2-0 g paracetamol on gastric potential difference was compared with that of 600 mg aspirin. In contrast with salicylates, paracetamol caused no significant alteration in movement of H+ and Na+ ions over control periods. Aspirin causes a significant fall in transmucosal potential difference (PD) across gastric mucosa of 15 mv, while paracetamol cuased no significant change. Paracetamol in a dose four times that recommended does not alter gastric ionic fluxes or potential difference. These studies support choice of paracetamol as analgesic over aspirin where damage to gastric mucosa may be critical. (+info)
Chemokine mRNA expression in gastric mucosa is associated with Helicobacter pylori cagA positivity and severity of gastritis. (2/4985)AIM: To investigate the association between the quantity of gastric chemokine mRNA expression, severity of gastritis, and cagA positivity in Helicobacter pylori associated gastritis. METHODS: In 83 dyspeptic patients, antral and corpus biopsies were taken for semiquantitative reverse transcription polymerase chain reaction (RT-PCR) and histological grading of gastritis. Gastritis was evaluated by visual analogue scales. Quantities of chemokine (IL-8, GRO alpha, ENA-78, RANTES, MCP-1) RT-PCR products were compared with G3PDH products. Each sample was also evaluated for the presence of cagA and ureA mRNA by RT-PCR. RESULTS: mRNA expression of all five chemokines was significantly greater in H pylori positive than in H pylori negative mucosa. In H pylori positive patients, in the antrum C-X-C chemokine mRNA expression was significantly greater in cagA positive patients than in cagA negative patients, but there were no significant differences in C-C chemokine mRNA expression. In H pylori positive patients, chemokine mRNA expression in the corpus was less than in the antrum. In contrast to the antrum, only GRO alpha mRNA expression was significantly greater in cagA positive infection. Polymorphonuclear cell infiltration was correlated with C-X-C chemokine mRNA expression. Significant correlations were also found between bacterial density and C-X-C chemokine mRNA expression. CONCLUSIONS: In H pylori infection, C-X-C chemokines may play a primary role in active gastritis. Infection with cagA positive H pylori induces greater gastric chemokine mRNA expression in the antral mucosa, which may be relevant to the increased mucosal damage associated with cagA positive H pylori infection. (+info)
Precancerous lesions in two counties of China with contrasting gastric cancer risk. (3/4985)BACKGROUND: Gastric cancer (GC) is one of the most common cancers worldwide and shows remarkable geographical variation even within countries such as China. Linqu County in Shandong Province of northeast China has a GC rate that is 15 times higher than that of Cangshan County in Shandong, even though these counties are within 200 miles of each other. METHOD: In order to evaluate the frequency of precancerous gastric lesions in Linqu and Cangshan Counties we examined 3400 adults in Linqu County and 224 adults in Cangshan County. An endoscopic examination with four biopsies was performed in each individual of the two populations. RESULTS: The prevalence of intestinal metaplasia (IM) and dysplasia (DYS) was 30% and 15.1%, respectively, in Linqu compared to 7.9% and 5.6% in Cangshan (P < 0.01). Within these histological categories, advanced grades were found more often in Linqu than in Cangshan. The prevalences of IM and DYS were more common at each biopsy site in Linqu, where the lesions also tended to affect multiple sites. CONCLUSIONS: The findings of this study support the concept that IM and DYS are closely correlated with risks of GC and represent late stages in the multistep process of gastric carcinogenesis. (+info)
Phenotypic and functional characterisation of myofibroblasts, macrophages, and lymphocytes migrating out of the human gastric lamina propria following the loss of epithelial cells. (4/4985)BACKGROUND: The basement membrane of human colonic mucosa contains numerous discrete pores. We have recently shown that following loss of the surface epithelium, many cells migrate out of the colonic lamina propria via basement membrane pores. AIMS: To characterise cells migrating out via basement membrane pores of the human gastric lamina propria, following loss of the surface epithelium. METHODS: Fresh human gastric mucosal samples were completely denuded of epithelial cells and placed in culture. Tissue samples were studied by electron microscopy (EM) and cells by EM, FACS analysis, immunohistochemistry, and reverse transcription polymerase chain reaction (RT-PCR). RESULTS: EM showed numerous discrete pores (0. 65-8.29 microm in diameter) in the subepithelial basement membrane. During culture of mucosal samples denuded of epithelial cells, lymphocytes, macrophages, and myofibroblasts migrated out of the lamina propria via the basement membrane pores. The lymphocytes were predominantly CD45RO+ and CD69+ T cells. Macrophages were shown to express cyclooxygenase (COX) 1 and 2 enzymes. Myofibroblasts were established in culture and, despite prolonged culture and passage, retained their phenotype. They expressed mRNA and protein for COX 1 and 2 enzymes and their release of prostaglandin E2 was inhibited by selective COX 1 and 2 inhibitors. CONCLUSIONS: Lamina propria cells migrating out of cultured denuded gastric mucosal samples have been characterised phenotypically and functionally. Such cells would be suitable for studies of their interactions with epithelial cells and also with Helicobacter pylori and its products. (+info)
Influence of a new antiulcer agent, ammonium 7-oxobicyclo (2, 2, 1) hept-5-ene-3-carbamoyl-2-carboxylate (KF-392) on gastric lesions and gastric mucosal barrier in rats. (5/4985)Antiulcer effects of KF-392 were studied in several experimental gastric ulcer models in rats. It was found that KF-392 given orally at 1.0 to 5.0 mg/kg had a marked suppression on the developments of Shay ulcer as well as the aspirin-, stress-, and reserpine-induced gastric lesions. The influence of KF-392 on gastric mucosal barrier was also studied. A back diffusion of H+ into the gastric mucosa and a fall of transmucosal potential difference were induced with KF-392 given orally at the above mentioned doses. KF-392 given s.c. at 5.0 mg/kg showed no inhibition of Shay ulcer and no induction of back diffusion of H+ into the gastric mucosa. (+info)
Isosmotic modulation of Ca2+-regulated exocytosis in guinea-pig antral mucous cells: role of cell volume. (6/4985)1. Exocytotic events and changes of cell volume in mucous cells from guinea-pig antrum were examined by video-enhanced optical microscopy. 2. Acetylcholine (ACh) evoked exocytotic events following cell shrinkage, the frequency and extent of which depended on the ACh concentration. ACh actions were mimicked by ionomycin and thapsigargin, and inhibited by Ca2+-free solution and Ca2+ channel blockers (Ni2+, Cd2+ and nifedipine). Application of 100 microM W-7, a calmodulin inhibitor, also inhibited the ACh-induced exocytotic events. These results indicate that ACh actions are mediated by intracellular Ca2+ concentration ([Ca2+]i) in antral mucous cells. 3. The effects of ion channel blockers on exocytotic events and cell shrinkage evoked by ACh were examined. Inhibition of KCl release (quinine, Ba2+, NPPB or KCl solution) suppressed both the exocytotic events and cell shrinkage evoked by ACh. 4. Bumetanide (inhibition of NaCl entry) or Cl--free solution (increasing Cl- release and inhibition of NaCl entry) evoked exocytotic events following cell shrinkage in unstimulated antral mucous cells and caused further cell shrinkage and increases in the frequency of exocytotic events in ACh-stimulated cells. However, Cl--free solution did not evoke exocytotic events in unstimulated cells in the absence of extracellular Ca2+, although cell shrinkage occurred. 5. To examine the effects of cell volume on ACh-evoked exocytosis, the cell volume was altered by increasing the extracellular K+ concentration. The results showed that cell shrinkage increases the frequency of ACh-evoked exocytotic events and cell swelling decreases them. 6. Osmotic shrinkage or swelling caused the frequency of ACh-evoked exocytotic events to increase. This suggests that the effects of cell volume on ACh-evoked exocytosis under anisosmotic conditions may not be the same as those under isosmotic conditions. 7. In antral mucous cells, Ca2+-regulated exocytosis is modulated by cell shrinkage under isosmotic conditions. (+info)
KRAS mutations predict progression of preneoplastic gastric lesions. (7/4985)Eight hundred sixty-three subjects with atrophic gastritis were recruited to participate in an ongoing chemoprevention trial in Narino, Colombia. The participants were randomly assigned to intervention therapies, which included treatment to eradicate Helicobacter pylori infection followed by daily dietary supplementation with antioxidant micronutrients in a 2 x 2 x 2 factorial design. A series of biopsies of gastric mucosa were obtained according to a specified protocol from designated locations in the stomach for each participant at baseline (before intervention therapy) and at year three. A systematic sample of 160 participants was selected from each of the eight treatment combinations. DNA was isolated from each of these biopsies (n = 320), and the first exon of KRAS was amplified using PCR. Mutations in the KRAS gene were detected using denaturing gradient gel electrophoresis and confirmed by sequence analysis. Of all baseline biopsies, 14.4% (23 of 160) contained KRAS mutations. Among those participants with atrophic gastritis without metaplasia, 19.4% (6 of 25) contained KRAS mutations, indicating that mutation of this important gene is likely an early event in the etiology of gastric carcinoma. An important association was found between the presence of KRAS mutations in baseline biopsies and the progression of preneoplastic lesions. Only 14.6% (20 of 137) of participants without baseline KRAS mutations progressed from atrophic gastritis to intestinal metaplasia or from small intestinal metaplasia to colonic metaplasia; however, 39.1% (9 of 23) with baseline KRAS mutations progressed to a more advanced lesion after 3 years [univariate odds ratio (OR), 3.76 (P = 0.05); multivariate OR adjusted for treatment, 3.74 (P = 0.04)]. In addition, the specificity of the KRAS mutation predicted progression. For those participants with G-->T transversions at position 1 of codon 12 (GGT-->TGT), 19.4% (5 of 17) progressed (univariate OR, 2.4); however, 60.0% (3 of 5) of participants with G-->A transitions at position 1 of codon 12 (GGT-->AGT) progressed (univariate OR, 8.7; P = 0.004 using chi2 test). (+info)
Quantitative assessment of gastric atrophy using the syntactic structure analysis. (8/4985)AIM: To assess the topographical relation between gastric glands, using the minimum spanning tree (MST), to derive both a model of neighbourhood and quantitative representation of the tissue's architecture, to assess the characteristic features of gastric atrophy, and to assess the grades of gastric atrophy. METHODS: Haematoxylin and eosin stained sections from corporal and antral biopsy specimens (n = 139) from normal patients and from patients with nonatrophic gastritis and atrophic gastritis of grades 1, 2, and 3 (Sydney system) were assessed by image analysis system (Prodit 5.2) and 11 syntactic structure features were derived. These included both line and connectivity features. RESULTS: Syntactic structure analysis was correlated with the semiquantitative grading system of gastric atrophy. The study showed significant reductions in the number of points and the length of MST in both body and antrum. The standard deviation of the length of MST was significantly increased in all grades of atrophy. The connectivity to two glands was the highest and most affected by the increased grade of atrophy. The reciprocal values of the Wiener, Randic, and Balaban indices showed significant changes in the volume of gland, abnormality in the shape of glands, and changes in irregularity and branching of the glands in both types of gastric mucosa. There was a complete separation in the MST, connectivity, and index values between low grade and high grade gastric atrophy. CONCLUSIONS: (1) Gastric atrophy was characterised by loss of the gland, variation in the volume, reduction in the neighbourhood, irregularity in spacing, and abnormality in the shape of the glands. (2) Syntactic structure analysis significantly differentiated minor changes in gastric gland (low grade atrophy) from high grade atrophy of clinical significance. (3) Syntactic structure analysis is a simple, fast, and highly reproducible technique and appears a promising method for quantitative assessment of atrophy. (+info)
Gastric mucosal barrier, drug induced acute erosive gastritis and stress ulcer<...
TY - JOUR. T1 - Gastric mucosal barrier, drug induced acute erosive gastritis and stress ulcer. AU - Mann, Nirmal S. AU - Mann, Surinder K. PY - 1977. Y1 - 1977. N2 - Gastric mucin probably plays an insignificant role in the protection of gastric mucosa. The metabolic integrity of the mucosal cells is important in the maintenance of the gastric mucosal barrier. Various drugs and stress break the gastric mucosal barrier, allowing increased back diffusion of hydrogen ions and causing gastric erosions, stress ulcers, and gastric bleeding. Presence of acid seems to be necessary for the occurrence of these lesions. Acute gastric mucosal lesions as a cause of upper gastrointestinal bleeding are best diagnosed by fiberoptic endoscopy. Antacids may be effective in preventing these lesions.. AB - Gastric mucin probably plays an insignificant role in the protection of gastric mucosa. The metabolic integrity of the mucosal cells is important in the maintenance of the gastric mucosal barrier. Various ...
The therapeutic effect of zerumbone on chronic gastritis via antioxidant mechanisms
Effects of zerumbone on chronic gastritis remain unclear. The purpose of this study was to investigate the mechanism of the protective effect of zerumbone on the treatment of chronic gastritis in rats. The animal models of chronic gastritis in rats were established, and the surface damage of gastric mucosa was observed by gross anatomy; the changes of gastric mucosal tissue and surface morphology were observed by pathological sections of gastric mucosal tissues; the expressions of heme oxygenase-1 (HO-1) and nuclear factor E2-related factor 2 (Nrf-2) proteins of gastric mucosal tissues in each group were detected by western blot analysis; the activities of superoxide dismutase (SOD) and catalase (CAT) as well as the contents of reduced glutathione (GSH) and malondialdehyde (MDA) in gastric mucosal tissues were detected by kits. The results indicated that zerumbone could significantly relieve red and swelling as well as erosion of the gastric mucosal tissues in rats with chronic gastritis; ...
Geranylgeranylacetone induces heat shock proteins in cultured guinea pig gastric mucosal cells and rat gastric mucosa
GGA may induce transcriptional activation of HSP genes, and this novel action may increase gastric mucosal defense at conditions of stress.
Apple polyphenol extracts prevent damage to human gastric epithelial cells in vitro and to rat gastric mucosa in vivo | Gut
Several studies indicate that naturally occurring antioxidants exert protective biochemical effects in a number of biological experimental systems. In particular, phenolic antioxidants, which are widely distributed in vegetable foods, are considered to play an important role in the prevention of oxidative damage in living systems.32 Because generation of ROS in the stomach greatly contributes to the damaging effect exerted by a number of ulcerogens,2-4 we sought to investigate whether APE prevented oxidative stress induced injury to cultured gastric mucous cells in vitro, under conditions independent of acid secretion or systemic factors, including blood flow.. Our data indicate that APE counteract the damaging effect of X-XO generated ROS in gastric epithelial cells and that this protective effect seems to be mainly attributable to the major components of APE (that is, CAT and CA). This effect is associated with permeation of gastric cells by apple phenolic compounds and seems to be due to ...
Oral bacteria regulate gastric mucosal defense via bioactivation of dietary nitrate
The human stomach normally contains high levels of bioactive nitric oxide (NO). This NO derives from salivary nitrate (NO3-) that is converted to nitrite (NO2-) by oral bacteria and thereafter non-enzymatically reduced in the acidic gastric lumen to NO. Nitrate is a common component in vegetables, and after ingestion it is absorbed in the small intestine. Interestingly, circulating nitrate is then concentrated by the salivary glands. Hence, intake of nitrate-rich vegetables results in high levels of NO in the stomach. The physiological effects of the high concentration of NO gas normally present in the gastric lumen have been hitherto unknown, and the present investigations were therefore conducted to address this issue.. NO produced in the gastric lumen after nitrate ingestion increased gastric mucosal blood flow and the thickness of the firmly adherent mucus layer in the stomach. The blood flow and mucus layer are essential defense mechanisms that protect the mucosa from luminal acid and ...
A method to study cell proliferation kinetics in human gastric mucosa. | Gut
The purpose of this investigation was to study cell proliferation kinetics in human gastric mucosa. Biopsies were taken from the antral and fundic part of the stomach through a fibre-gastroscope and incubated in culture medium containing a DNA-precursor (3-H-thymidine). Autoradiographs were prepared by the dipping technique. The number of labelled cells and the total number of cells in all cross sections of foveolae containing one or more labelled cells were counted. The labelling index (LI), which is defined as the percentage of labelled cells in the progenitor cell region, was estimated. When only cross sections with labelled cells are taken into consideration, the labelling index will be a little overestimated. In order to reduce this error a formula for correction was worked out. Thirty-six patients with different gastric diseases were studied. The observer error was minimal, and the results were highly reproducible. It was not possible to demonstrate any correlation between the labelling ...
CiNii 論文 - Regulation of Intracellular pH : Role in Gastric Mucosal Defence ...
The gastric mucosa is constantly exposed to conditions that would normally be damaging to living cells. A complex defensive system has evolved that involves multiple mechanisms arranged in a laminar fashion, that as a whole constitute the gastric mucosal barrier to acid. As antisecretory therapy becomes perfected, more attention has been focused on these defensive components of the gastric mucosal barrier in disease. Recently, our laboratory has developed a means of measuring intracellular pH (pH,sub,i,/sub,), mucosal blood flow, acid secretion, surface cell acidification rate, and acid secretion simultaneously ,i,in vivo,/i,. This system has enabled our laboratory to explore how the different components of the gastric mucosal barrier interact so as to protect the pH,sub,i,/sub, of the surface cells under a variety of conditions. Analysis of these studies has revealed a significant inverse correlation between the initial fall in pH; of surface cells during luminal acid exposure and the thickness ...
Crosssection Of The Gastric Or Stomach Epithelium Showing The Numerous Gastric Pits On The Surface Of The Mucosa Sem Foto stock...
Guarda Foto stock di Crosssection Of The Gastric Or Stomach Epithelium Showing The Numerous Gastric Pits On The Surface Of The Mucosa Sem. Cerca foto premium ad alta risoluzione su Getty Images.
Cholecystokinin secretagogue-induced gastroprotection: Role of nitric oxide and blood flow<...
TY - JOUR. T1 - Cholecystokinin secretagogue-induced gastroprotection. T2 - Role of nitric oxide and blood flow. AU - West, Sonlee D.. AU - Helmer, Kenneth S.. AU - Chang, Lily K.. AU - Cui, Yan. AU - Greeley, George H.. AU - Mercer, David W.. PY - 2003/3/1. Y1 - 2003/3/1. N2 - This study was done to examine the role of CCK in gastric mucosal defense and to assess the gastroprotective roles of nitric oxide and blood flow. In rats, the CCK secretagogues oleate and soybean trypsin inhibitor augmented gastric mucosal blood flow and prevented gastric injury from luminal irritants. Type A CCK receptor blockade negated CCK secretagogue-induced gastroprotection and exacerbated gastric injury from bile and ethanol but did not block adaptive cytoprotection. CCK secretagogue-induced gastroprotection and hyperemia were negated by nonselective nitric oxide synthase (NOS) inhibition (nG-nitro-L-arginine methyl ester) but not by selective inducible NOS inhibition (aminoguanidine). Gastric mucosal ...
Stomach mucosa, light micrograph and illustration - Stock Image F016/8749 - Science Photo Library
Stomach mucosa. Light micrograph (bottom left) and computer illustration (top right) of the lining of the stomach, known as the mucosa. The stomach is a muscular sac involved in storage and digestion of food. The surface of the mucosa consists of simple columnar cells (dark purple in micrograph) that secrete mucus. The mucus protects the stomach lining from digestive acids and enzymes that act on food in the stomach. Beneath the columnar cells are gastric pits, the glands that make the acids and enzymes needed to digest food. - Stock Image F016/8749
Omeprazole preserves the RER in chief cells and enhances re‑epithelialization of parietal cells with SOD and AQP‑4 up...
The balance of protective and aggressive factors in the gastric mucosal barrier is an important consideration in gastrointestinal diseases (4). Gastric acid, pepsin, and external stimuli are known aggravating factors of gastric mucosal cells, while microcirculatory system, HCO3−, prostaglandins, epidermal growth factor synthesis, and epithelial cell reconstitution are gastro-protective factors that maintain integrity of the gastric mucosal layer. Obviously, there are several viewpoints in association with the effect of ethanol on gastric mucosal cells. However, the main pathogenesis of ethanol-induced gastritis is vascular damage followed by mucosal cell-hypoxia, -degeneration, and -necrosis, respectively. The decline of anti-oxidant level and over production of oxygen free radicals especially super-oxide and hydrogen peroxide, are also link to ethanol-induced gastric injury and play a crucial role to further induce gastric inflammatory response. In addition, ethanol itself destroys gastric ...
Aberrant upregulation of 14-3-3ơ expression serves as an inferior prognostic biomarker for gastric cancer | BMC Cancer | Full...
14-3-3ơ is an intracellular, phosphoserine binding protein and proposed to be involved in tumorigenesis. However, the expression dynamics of 14-3-3ơ and its clinicopathological/prognostic significance in human tumors are still controversial. The method of immunohistochemistry (IHC) and Western blot were utilized to examine the protein expression of 14-3-3ơ in gastric cancer and paired normal adjacent gastric mucosal tissues. Receive operating characteristic (ROC) curve analysis was employed to determine a cutoff score for 14-3-3ơ expression in a training set (n = 66). For validation, the ROC-derived cutoff score was subjected to analysis of the association of 14-3-3ơ expression with patient outcome and clinical characteristics in a testing set (n = 86) and overall patients (n = 152). The expression frequency and expression levels of 14-3-3ơ were significantly higher in gastric cancer than in normal gastric mucosal tissues. Correlation analysis demonstrated that high expression of 14-3-3ơ in
Depth-Resolved Imaging of Alterations in Mucosal Microcirculation - Sarah Ruderman
Using a novel optical technique, polarization-gated spectroscopy, our group detected an early increase in blood supply (EIBS) prior to any morphological manifes...
Gastric mucosa of BALB/c mouse infected with H. pylori | Open-i
Gastric mucosa of BALB/c mouse infected with H. pylori for 1 week. Significant infiltration of inflammatory cells is not seen. H & E stain. Original magnifi
The cytology of gastric mucosa - MyScienceWork
The cytology of gastric mucosa: Smears and sections were obtained from various labelled points on the mucosal surface of 25 freshly-excised stomachs, and the ap
Histamine, cAMP, and Activation of Piglet Gastric Mucosa - PubMed
The involvement of cAMP as a second messenger for histamine-induced H+ secretion was studied in a physiologically active, in vitro preparation of piglet gastric mucosa. During the first 5--10 min of stimulation with either histamine or the cAMP phosphodiesterase inhibitor 3-isobutyl-1,4-methylxanthi …
How to restore the stomach: drugs, reducing the gastric mucosa
Gastrointestinal diseases often do not cause much discomfort, and felt a slight indigestion after eating. Any irregularities in the digestive organs indicate changes in the frequency and character of stool.. The presence of any of these symptoms may indicate pathological conditions, to identify which will help timely survey. Sometimes these symptoms to report breaches of the mucosa of the body, so doctors do not recommend ignore them.. ...
CiNii Articles - TAKESHIMA KAZUHITO
Isolation and characterization of a gene expressed mainly in the gastric epithelium, a novel member of the ep37 family that belongs to the βγ-crystallin superfamily （1998 ...
Efficacy of Albis for the Prevention of Gastric Mucosal Injury Concomitant with the Use of Low-Dose Aspirin: A Prospective,...
In this study, Albis (containing ranitidine, sucralfate, and bismuth) prevented the gastric mucosal injury provoked by long-term use of ASA. There was no development of peptic ulcer in either of the groups during the study period. This might be due to the study period being too short to allow peptic ulcer to develop by the use of low-dose ASA. However, gastric mucosal injury measured by the MLS developed, but was reduced by concomitant use of Albis. Although several studies have reported the efficacy of PPIs or H2RAs in the prevention of peptic ulcer and gastric mucosal injury caused by ASA, there is no report of the efficacy of fixed-dose combination of H2RA, sucralfate, and bismuth [3,7,11,14-17]. This is the first prospective trial to evaluate the efficacy of combination of H2RA, sucralfate, and bismuth for the prevention of peptic ulcer or gastric mucosal injury due to long-term use of lowdose ASA ...
Ii-CS on gastric epithelial cells interacts with CD44 on T cells and induces their proliferation<...
TY - JOUR. T1 - Ii-CS on gastric epithelial cells interacts with CD44 on T cells and induces their proliferation. AU - Barrera, C. A.. AU - Chan, T.. AU - Crowe, S. E.. AU - Ernst, P. B.. AU - Reyes, Victor. PY - 2003. Y1 - 2003. KW - CD44. KW - Gastric epithelial cell. KW - H. pylori. UR - http://www.scopus.com/inward/record.url?scp=0038579613&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0038579613&partnerID=8YFLogxK. M3 - Article. VL - 987. SP - 285. EP - 287. JO - Annals of the New York Academy of Sciences. JF - Annals of the New York Academy of Sciences. SN - 0077-8923. ER - ...
Differential Activation of Mitogen-Activated Protein Kinases in AGS Gastric Epithelial Cells by cag+ and cag− Helicobacter...
We have shown that contact with H. pylori rapidly activates ERK1, ERK2, p38, JNK p46, and JNK p54 MAP kinases in AGS gastric epithelial cells. We also find that H. pylori cag+ strains are more potent than cag− strains in inducing MAP kinase activation. Differential MAP kinase activation by cag+ and cag−H. pylori strains is particularly evident for JNK phosphorylation and appears to be dependent upon genes within the cag pathogenicity island. Inhibitors of p38 and MEK1 MAP kinases prevent H. pylori-induced IL-8 production. However, p38 and MEK1 MAP kinase activity do not appear to be essential for H. pylori-induced NF-κB activation.. H. pylori has adapted to interact specifically with gastric-type epithelial cells. H. pylori infection is limited to areas of the gastrointestinal tract that are lined by gastric epithelium, and the bacterium is known to activate several gastric epithelial cell signaling events. Previous studies have shown that adherence of H. pylori to AGS gastric epithelial ...
WHO | Helicobacter pylori
The isolation of Helicobacter pylori from the human gastric mucosa in 1982 and the demonstration of its involvement in gastritis, peptic ulcer disease and gastric adenocarcinomas have radically changed our perception of these diseases. H. pylori is a small, spiral, gram-negative bacillus that appears to inhabit the mucous layer overlying the gastric epithelial cells in humans. It produces a potent urease, which, by producing ammonia, may help to neutralize gastric acid, but the mechanism by which the bacteria produces gastric inflammation is not clear as it does not invade the mucosa. Development of atrophy and metaplasia of the gastric mucosa are strongly associated with H. pylori infection. Oxidative and nitrosative stress in combination with inflammation plays an important role in gastric carcinogenesis. More. Last updated: 25 Janury 2008. ...
Ethanol, after intragastric administration, penetrates deeply into the gastric mucosa because of high lipid solubility and, at concentrations of 50-100%, causes microvascular damage and hemorrhagic lesions (23, 34, 37, 38, 41). Ethanol-induced injury to the gastric mucosa is a time-related process in which disruption or exfoliation of the gastric surface epithelium is followed by necrosis of deeper mucosal layers, including the mucosal proliferative zone and the microvasculature (23,37, 38, 41). Angiogenesis is a prerequisite for the healing of ethanol-induced deep gastric mucosal damage. Our previous study has shown that ethanol-induced injury to gastric mucosa triggers an angiogenic response as well as an increase in bFGF, a known angiogenic factor, in the mucosa bordering necrosis (36, 39).. The present study demonstrates for the first time that ethanol-induced injury to the gastric mucosa activates VEGF gene expression as reflected by increases in VEGF at both the transcriptional and ...
Download Atlas of Esophageal Disease and Intervention: A by Shanda H. Blackmon, Min P. Kim, Karen J. Dickinson PDF - Facial...
Visualizing the mucosal surface may require using forceps to hold the specimen open (Fig. 19), unlike the specimens pictured in the other gross photographs. Histology shows marked thickening and fibrosis of the lamina propria, submucosa, and muscularis propria (Fig. 20). (Compare the normal histology in Fig. ) Fig. 19 Stricture of the esophagus, fresh specimen 44 Fig. 20 Histology of stricture (H & E, ×20) B. Gorman 2 Histologic Anatomy 45 Inlet Patch The inlet patch is characterized by ectopic gastric mucosa that is surrounded by normal squamous mucosa (Fig. A b Fig. 21 (a) Inlet patch (H & E, ×40). The mucosa on the left side of this photomicrograph shows essentially normal gastric mucosa with foveolar and glandular epithelium. The mucosa on the right shows normal esophageal squamous epithelium. (b) Inlet patch (H & E, ×200). On higher power, the gastric mucosa of the inlet patch is identical to that seen in the stomach, with foveolar epithelium overlying gastric glands composed of mucus ...
The Development of Intracellular Membranes Concomitant with the Appearance of HCL Secretion in Oxyntic Cells of the...
Bullfrog tadpole stomachs of various metamorphic stages were examined to determine the fine-structural development of oxyntic cells and to correlate observed morphological development with the capacity to secrete HCl. It was found that in vitro tadpole stomachs can consistently be stimulated to secrete acid by stage XXIV of metamorphosis, when tail reabsorption is nearly complete. Concomitant with the appearance of HCl secretion, identifiable oxyntic cells were found in the gastric glands.. Prior to stage XXIV (stages XXI and XXII) the majority of cells present in the developing gastric glands exhibit features of cytological organization characteristic of undifferentiated cells: large nuclei, relatively scantry cytoplasm, and numerous ribosomal particles within the cytoplasmic matrix. The newly differentiated oxyntic cells of stage XXIV tadpole stomachs are recognizable by the accumulation of tubular members of the smooth-surfaced endoplasmic reticulum in the apical portion of the cells. These ...
Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case | The Journal of the American...
Lawson R. Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case. J Am Osteopath Assoc 1968;67(11):1292. doi: .. Download citation file:. ...
Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus...
Chem Biol Interact. 2009 Aug 14;180(3):499-505. doi: 10.1016/j.cbi.2009.04.006. Epub 2009 May 3. Research Support, Non-U.S. Govt
Helicobacter pylori (H. pylori) is implicated in human gastric mucosa. Fork head box M1 (FoxM1), the key positive regulator of cell proliferation is overexpressed in gastric cancer. MicroRNAs are important post-transcriptional regulators of gene expression. In this study, we explored the effect of H. pylori infection on FoxM1 expression and possible mechanisms. The expression of FoxM1 was gradually increased in human gastric specimens from inflammation to cancer. FoxM1 was time- and concentration-dependently upregulated in gastric epithelial-derived cell lines infected with H. pylori. CagA, the key virulence factor of H. pylori, was associated with increasing FoxM1 expression. H. pylori and CagA inhibited the expression of P27Kip1 (cylcin-dependent kinase inhibitor 1B, CDKN1B) and promoted cell proliferation by upregulating FoxM1. The expression of hsa-miR-370 was decreased in human gastritis and gastric cancer. FoxM1 was directly downregulated by hsa-miR-370 in gastric cell lines. H. pylori and ...
Pathways of gastro protective potential of chamomile in indomethacin induced ulcerogenic in rats | International Journal of...
Indomethacin (IND) is an extensively used drug. However, it provokes aggressive ulcerogenic potential. Chamomile is a widely used as natural herb with a powerful antioxidant activity. This study aims to assess the effects of chamomile flowers extract (CFE) in IND induced peptic ulcer (PU). Fifty rats classified to five groups; control, ulcer, and pretreated groups with CFE (200 mg/kg), pretreated with ranitidine RAN (50 mg/kg), and pretreated with CFE+RAN for 14 days pre-ulcer induction. Pretreatment with CFE and/or RAN significantly decreased ulcer index, gastric acidity, pepsin activity, gastric oxidative stress biomarkers, serum anti-inflammatory cytokines, and histopathological changes induced by IND. The pretreated groups significantly elevated gastric enzyme antioxidant activity, mucin content and gastric mucosal prostaglandin E2 with comparison to IND group. Pretreatment with CFE+RAN displayed the most gastroprotective effects compared with pretreated with either CFE or RAN alone. ...
Investigations on gastric mucosal protective mechanisms are focused mainly on the local mucosal processes. Much less is known about how the central nervous system may influence the gastric mucosal defense. However, gastric mucosal protection induced by a central mechanism was described recently (Tache et al., 1994; Gyires, 1997;Guidobono et al., 1998; Kaneko et al., 1998; Yang et al., 1999). In our present study, the role of central opioid receptors was analyzed by means of selective δ- and μ-opioid receptor agonists. It was found that both the selective δ- and μ-opioid receptor agonists injected either i.c.v. or i.c. exerted protective effect against acidified ethanol-induced lesions; the rank order of potency was β-endorphin , DAGO , DADLE , deltorphin II , DPDPE following i.c.v. injection and deltorphin II , β endorphin , DPDPE , DAGO , DADLE following i.c. administration. The results suggest that activation of supraspinal δ- and μ-opioid receptors may induce gastric mucosal ...
antral mucosa with extremely focal chronic active gastritis. what is the treatment for this? can it come back with stress? |...
Dr. Donald Colantino answered: Gastritis: This should resolve with the taking of prolosec type medication. However I feel that its...
Honey and Apoptosis in Human Gastric Mucosa
Academic Journals Database is a universal index of periodical literature covering basic research from all fields of knowledge, and is particularly strong in medical research, humanities and social sciences. Full-text from most of the articles is available. Academic Journals Database contains complete bibliographic citations, precise indexing, and informative abstracts for papers from a wide range of periodicals.
Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands.
Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was cond
Dose-dependent inhibition of gastric injury by hydrogen in alkaline electrolyzed drinking water | BMC Complementary Medicine...
Hydrogen has been reported to relieve damage in many disease models, and is a potential additive in drinking water to provide protective effects for patients as several clinical studies revealed. However, the absence of a dose-response relationship in the application of hydrogen is puzzling. We attempted to identify the dose-response relationship of hydrogen in alkaline electrolyzed drinking water through the aspirin induced gastric injury model. In this study, hydrogen-rich alkaline water was obtained by adding H2 to electrolyzed water at one atmosphere pressure. After 2 weeks of drinking, we detected the gastric mucosal damage together with MPO, MDA and 8-OHdG in rat aspirin induced gastric injury model. Hydrogen-dose dependent inhibition was observed in stomach mucosal. Under pH 8.5, 0.07, 0.22 and 0.84 ppm hydrogen exhibited a high correlation with inhibitory effects showed by erosion area, MPO activity and MDA content in the stomach. Gastric histology also demonstrated the inhibition of damage by
Mucosal prostaglandin E2 levels in patients with the ga | Open-i
Mucosal prostaglandin E2 levels in patients with the gastric ulcer before and after their ulcers were healed. Both the antral and duodenal PG E2 are significant
Gentaur Molecular :US Biomax \ Mouse stomach tissue array, 100 cases 100 cores, 50 from different male, 50 from different...
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SIU SOM Histology GI
The duodenal surface epithelium shown here consists of absorptive cells with scattered goblet cells, in contrast to that of stomach which consists uniformly of surface mucous cells.. Note that Brunners glands lie beneath the muscularis mucosae, in the submucosa. Click on the rectangle for a magnified image of the intestinal epithelium, or.... ...
Role of histamine H2 receptors in the mechanism of formation of experimental gastric ulcers induced in rats by various...
Dystrophic lesions of the gastric mucosa were observed to be formed and the pepsinogen content was reduced by 57% in the gastric mucosa of rats exposed to various experimental stressors...
The Stomach Room - Stephan Mathieu - FrequencyLib (CD, Album)
The stomach mucosas epithelial lining consists only of surface mucus cells, which secrete a protective coat of alkaline mucus. A vast number of gastric pits dot the surface of the epithelium, giving it the appearance of a well-used pincushion, and mark the entry to each gastric gland, which secretes a complex digestive fluid referred to as gastric juice ...
Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats...
Non-steroidal anti-inflammatory drugs (NSAIDs) can result in peptic ulcer disease (PUD) which is a common condition worldwide. The aim of this study was to evaluate the antiulcer properties of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone) (HPTP) chalcone in rats using indomethacin as ulcerogenic agent. None of the rats showed symptoms of kidney and liver toxicity during the term of the study. Administration of HPTP had decreased the acidity, increased gastric wall mucus and flattening of gastric mucosa and reducing erosive gastric damage area. HPTP also showed dose dependent increase in SOD, GPx activity and PGE2 level and decrease MDA. H & E stain showed decreased infiltration of leucocytes with edema of submucosal layer. PAS staining showed intense uptake of magenta color of gastric wall mucus in rats fed with HPTP, and immunohistochemical staining of gastric mucosa revealed over-expression of HSP70 protein, down-expression of Bax protein and over expression of TGF-β in rats administered with HPTP. This
False-colour SEM of gastric glands of stomach - Stock Image P510/0042 - Science Photo Library
Gastric gland: false-colour scanning electron micrograph (SEM) of the mucous membrane lining the stomach, showing the shadowy entrances to a number of gastric glands. The glands secrete gastric juice (hydrochloric acid & the enzyme pepsin) and a protective mucous, derived from the simple, columnar cells (moss-like) that comprise the mucosa. Gastric glands are formed by simple invagination or tubular ingrowth of this mucosa into the underlying layer of tissue, the lamina propria. Magnification: x300 at 6x7cm size. - Stock Image P510/0042
Ulcer Index financial definition of Ulcer Index
Definition of Ulcer Index in the Financial Dictionary - by Free online English dictionary and encyclopedia. What is Ulcer Index? Meaning of Ulcer Index as a finance term. What does Ulcer Index mean in finance?
Positive cells in gastric mucosa of ctsz2/2 (p = 0.009) and wt mice | GlyT1 inhibitor glyt1inhibitor.com
Positive cells in gastric mucosa of ctsz2/2 (p = 0.009) and wt mice (p = 0.001). Compared to wt animals with no further increase in F4/80 positivity, ctsz2/2
Cyclooxygenase-2-selective inhibitors impair glomerulogenesis and renal cortical development. - Semantic Scholar
BACKGROUND Antenatal exposure to nonsteroidal anti-inflammatory drugs (NSAIDs) has been associated with renal dysgenesis in humans. METHODS These studies characterized cyclooxygenase-2 (COX-2) versus COX-1-selective inhibition on nephrogenesis in the rodent using histomorphometry, immunohistology, and in situ hybridization. RESULTS Administration of a COX-2-selective inhibitor (SC58236), started during pregnancy until weaning, significantly impaired development of the renal cortex and reduced glomerular diameter in both mice and rats. An identical phenotype was demonstrated in COX-2 -/- mice. In contrast to its effects on the developing kidney, a COX-2 inhibitor had no effect on glomerular volume in adult mice. This effect was specific for COX-2 because maternal administration of a COX-1-selective inhibitor (SC58560) did not affect renal development despite significantly inhibiting gastric mucosal prostaglandin E2 (PGE2) synthesis in pups. The expression of COX-2 immunoreactivity peaked in the first
Effects of two alfalfa preparations with different particle sizes on the gastric mucosa in weanlings: alfalfa chaff versus...
Background Feeding alfalfa hay is often recommended for its buffering components, like protein and calcium, to prevent lesions of the gastric mucosa in horses. Until now, there has been no information...
Anti-oxidative Herbs and Indomethacin-Induced Rat Gastric Mucosal Lesions: Protection by GamiHyangsa-Yukgunja
Anti-oxidative Herbs and Indomethacin-Induced Rat Gastric Mucosal Lesions: Protection by GamiHyangsa-Yukgunja Heung Mook Shin (Acce...
We previously reported that gastrin induced PAI-2 in gastric epithelial cells via activation of PKC and RhoA, which in part triggered release of an unidentified paracrine mediator (11) . The present findings therefore extend these studies both by identification of H. pylori as a regulator of PAI-2 in gastric epithelial cells and by demonstration of the role of NFκB and of IL-8 and COX-2 as mediators of the response. It is well recognized that NFκB is activated by H. pylori and in turn leads to induction of IL-8 and COX-2 (28 , 33 , 34) . Less clear, however, are putative targets within the gastric epithelium that might mediate the progression to cancer and the integrative mechanisms that might account for differential cell signaling in tissues as complex as the gastric mucosa. The present observations indicate that PAI-2 should now be considered a putative target of NFκB activation by H. pylori. It seems, however, that the role of NFκB is limited to cells exposed directly to H. pylori and ...
Chapter 5 (page 20)
The mucus-secreting columnar cells lining the luminal surface and the pits are joined near their free surfaces to each other by tight junctions (Ham l974). It is surmized that this arrangement forms one of the mechanisms by which the underlying layers are protected against luminal acid. The supranuclear portions of the cells just below their free surfaces contain dense, homogeneous, spherical or ovoid granules consisting of a type of mucigen (Bloom and Fawcett l975). Upon release into the lumen, the granules give rise to the layer of mucus that covers the luminal surface of the mucosa. In the cells of the gastric pits, the granules become progressively less abundant at deeper levels, and in the bottom of the pits they from only a thin layer immediately beneath the cell surface. Cells of this kind continue into the necks of the gastric glands. Under physiological conditions, the surface mucus cells are continuously desquamated into the lumen and are completely replaced every 3 days (Ham l974; ...
Adenosine is the endogenous agonist at all adenosine receptors. Under resting physiological conditions, adenosine levels in the interstitial fluid are between 30 and 300 nM (7). This is sufficient to activate A1, A2A, and A3 adenosine receptors whenever these proteins are abundantly expressed on the cell surface. The local adenosine level increases 10-fold during hypoxia and 100- to 1,000-fold in ischemia (7, 18, 34, 72), allowing cell responses mediated via A2BR in these settings. The pharmacological and functional studies presented here have been conducted using parietal cells obtained from normal rabbit gastric mucosa, which are representative populations of native, nontransformed primary cells at rest. They provide evidence that A2B is the adenosine receptor that is preferentially, if not exclusively, expressed on the parietal cell membrane and mediates acid production via Gs activation. Moreover, activation kinetics indicate that the A2BR might act at full power to activate acid production ...
In the GC cell lines, the level ofmiR-200a/b methylation decreased and the level of expression increased after demethylation. In the human gastric mucosa, the miR-200a/b methylation levels increased in the following group order: H. pylori-negative control group, H. pylori-positive control group, and H. pylori-positive GC group. Conversely, the miR-200a/b expression levels decreased in the same order. In the H. pylori-persistence group, no significant changes were observed in the methylation and expression levels of miR-200a/b after 6 months, whereas the level of methyla-tion decreased and the level of expression of miR-200a/b increased significantly 6 months in the H. pylori-eradication group ...
BACTERIOLOGICAL AND EXPERIMENTAL STUDIES ON GASTRIC ULCER | Journal of Experimental Medicine | Rockefeller University Press
It must be assumed that some cause is operative in certain cases preventing the healing of defects in the gastric mucosa and is inoperative in others. Even though anhemolytic streptococci are present in practically all gastric ulcers, we cannot convince ourselves that these organisms have been proven as yet to be the factor which either initiates the ulceration or prevents healing. Nevertheless, the constant presence of streptococci in this type of lesion is a suggestive fact and further experiments to determine their significance are being undertaken. ...
EGD stomach that shows? - Health Tips
The most common finding in this study is an inflammatory process of the gastric mucosa - gastritis.In fact, after 20 years it is present in almost everyone.More serious is the discovery of the plague.Its danger lies in the fact that it can bleed and even to break through the wall of the stomach completely.In the event of signs of complications held emergency EGD.Gastric ulcer, among other things, is able to regenerate a more serious disease.. Much more disturbing is the discovery in the stomach cavity of a tumor process.Unpleasant discovery is also a gastric polyp.If you find something similar or just inflamed mucous area with signs of changing the structure of the doctor, most likely, with the consent of the patient will take a biopsy.Later removal of tissue samples are sent to patotsitologicheskoe research.The result will allow to say exactly what is is one or the other a modified portion of the gastric mucosa.. ...
TYPE OF STAINING:Sialomucin that have acid and neutral mucopolysaccharides stain purple. Normal gastric mucosa will stain only with PAS(red), but intestinal metaplasia will stain purple ...
I have missed my period for three months and my back, pelvis, stomach are hurting everyday - Doctors insight on HealthcareMagic
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RNAP - Inhibitors of MDM2, ALK and PARP
History & Aims Gastric carcinoma is usually related mostly to infection, which disrupts the gastric mucosa turnover and elicits an epithelial-mesenchymal transition (EMT) and preneoplastic transdifferentiation. pattern, characterized by an early transient YAP1 nuclear accumulation and stimulated YAP1/TEAD transcription, followed by nuclear LATS2 up-regulation leading to YAP1 phosphorylation and targeting for degradation. LATS2 and YAP1 reciprocally positively regulate each others expression. Loss-of-function experiments showed that LATS2 restricts contamination engages a number of signaling cascades that alienate mucosa homeostasis, including the Hippo LATS2/YAP1/TEAD pathway. In the hostCpathogen conflict, which generates an inflammatory environment and perturbations Pterostilbene of the epithelial turnover and differentiation, Hippo signaling appears as a protective pathway, restricting the?lack of gastric epithelial cell identification that precedes gastric?carcinoma advancement. infections; ...
What are the causes of gastrit
What are the causes of gastritis?, Gastritis is a kind of inflammation of the stomach mucosa (inflammation). This means that the white blood cells accumulate i
Welcome to CDC stacks | Browse Collections | Emerging Infectious Diseases
During the past decade, Helicobacter pylori has become recognized as one of the most common human pathogens, colonizing the gastric mucosa of almost all persons exposed to poor hygienic conditions from childhood. It also is often found, albeit with a ...
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The Ulcer Index indicator is a TA tool that measures the risk considering both main factors, the depth and the duration of price fall.
Ulcer Index Indicator Rules and Formula, Strategy | StockManiacs
Ulcer Index Indicator was developed by Peter Martin and Byron McCann in 1987. This is a volatility indicator that measures downside risk.
Gentaur Molecular :Panomics \ Human Stomach Total RNA \ QS0628
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Will bubble-powered microrockets zoom through the human stomach?
Scientists have developed a new kind of tiny motor that can propel itself through acidic environments, such as the human stomach, without any external energy source, opening the way to a variety of medical and industrial applications.
Mega Mucosa MUCOSAL SUPPORT
The first complete mucosal support supplement of its kindMegaMucosa is the first complete mucosal support supplement of its kind, formulated to REBUILD a healthy mucosal barrier. MegaMucosa also contains dairy-free immunoglobulins clinically shown to support a healthy immune response in the mucosa and a state-of-the-art flavobiotic clinically shown to support microbial diversity and alleviate barr
MissD wrote:Hi all - I had my band out in 2009 - put on 30kgs. So had the sleeve done in nov 2013. Obviously there was quite a lot of time to heal in that 4 yrs
Sleeping on stomach - 30s Pregnant With 1st Baby | Forums | What to Expect
When did you all stop sleeping on your stomachs? I am 10 weeks and still do, but recently it had started to be periodically uncomfortable. I am curious when people started making the switch to a new position.
... s or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa ... Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood. Histamine and ... It was once believed that tumors of ECL origin form after a prolonged inhibition of gastric acid secretion, however there is no ... data to support this conclusion and proton pump inhibitors are not thought to contribute to gastric cancer. ...
Secretion of gastric acid or alkaline pancreatic juice from the ectopic mucosa leads to ulceration in the adjacent ileal mucosa ... Jejunal, duodenal mucosa or Brunner's tissue were each found in 2% of ectopic cases. Heterotopic rests of gastric mucosa and ... This scan detects gastric mucosa; since approximately 50% of symptomatic Meckel's diverticula have ectopic gastric or ... Bleeding may be caused by: Ectopic gastric or pancreatic mucosa: Where diverticulum contains embryonic remnants of mucosa of ...
Vitamin B12 deficiency anemia
Intrinsic factor is produced by parietal cells of the gastric mucosa (stomach lining) and the intrinsic factor-B12 complex is ... Antibodies to intrinsic factor and parietal cells cause the destruction of the oxyntic gastric mucosa, in which the parietal ... Miederer, S.E. (1977). The Histotopography of the Gastric Mucosa. Thieme, ISBN 3-13-508601-1 Butler CC, Vidal-Alaball J, ... Impaired B12 absorption can also occur following gastric removal (gastrectomy) or gastric bypass surgery. In these surgeries, ...
Prabhu SR, Ranganathan S, Amarapurkar DN (November 1994). "Helicobacter pylori in normal gastric mucosa". J Assoc Physicians ... Since 1% to 3% of infected individuals are likely to develop gastric cancer, H. pylori-induced gastric cancer is the third ... Because of the usual lack of symptoms, when gastric cancer is finally diagnosed it is often fairly advanced. More than half of ... As evaluated in 2002, it is present in the gastric tissues of 74% of middle-aged adults in developing countries and 58% in ...
August 2005). "Prognostic value of translocation t(11;18) in tumoral response of low-grade gastric lymphoma of mucosa- ... Park, Jeong Bae (2014). "infection in gastric mucosa-associated lymphoid tissue lymphoma". World Journal of Gastroenterology. ... positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy". Lancet. 357 (9249): 39 ... "Regression of primary low-grade B-cell gastric lymphoma of mucosa-associated lymphoid tissue type after eradication of ...
Machen TE, Rutten MJ, Ekblad EB (February 1982). "Histamine, cAMP, and activation of piglet gastric mucosa". The American ... Increased mast cell activation is a common finding in the mucosa of patients with functional GI disorders. ... ▸ Treatment with ... mucosa of the lungs, and digestive tract, as well as the mouth, conjunctiva, and nose. Mast cells play a key role in the ...
Gastric mucosa at low magnification (H&E stain). Epithelial tissue is composed of closely packed cells, bound to each other by ...
In contrast, ID4 is highly expressed in normal gastric mucosa. There is an undefined but significant association seen in ID4 ... ID4 is closely associated with gastric cancer. The ID4 promoter region is hypermethylated and infrequently expressed in gastric ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-53. doi:10.1038/sj.onc. ... "Downregulation of ID4 by promoter hypermethylation in gastric adenocarcinoma". Oncogene. 22 (44): 6946-6953. doi:10.1038/sj.onc ...
Pepsin Lee D, Ryle AP (September 1967). "Pepsinogen D. A fourth proteolytic zymogen from pig gastric mucosa". The Biochemical ... Foltmann B (1981). "Gastric proteinases--structure, function, evolution and mechanism of action". Essays in Biochemistry. 17: ... Phe24-Phe and Phe25-Tyr bonds in the B chain of insulin The enzyme is a predominant endopeptidase in the gastric juice of ...
Findings on gastroscopy may include edematous gastric mucosa, and hyperperistalsis. Finding on colonoscopy may include: fragile ... mucosa, segmental erythema, longitudinal ulcer, and loss of haustrations Plain X-rays are often normal or show non-specific ...
Iodine in biology
Josefssson, M.; Ekblad, E. (2009). "Sodium Iodide Symporter (NIS) in Gastric Mucosa: Gastric Iodide Secretion". In Preedy, ... gastric mucosa, salivary glands, oral mucosa, arterial walls, thymus, epidermis, choroid plexus and cerebrospinal fluid, among ... In the proposed mechanism, the iodide ion functions in gastric mucosa as an antioxidant reducing species that detoxifies ... gastric mucosa, cervix, cerebrospinal fluid, arterial walls, ovary and salivary glands. In the cells of these tissues the ...
Zverkov IV, Vinogradov VA, Smagin VG (October 1983). "[Endorphin-containing cells in the gastric antral mucosa in duodenal ... Secrete motilin Gastric enteroendocrine cells are found in the gastric glands, mostly at their base. The G cells secrete ... K cells secrete gastric inhibitory peptide, an incretin, which also promotes triglyceride storage. L cells secrete glucagon- ... Goswami C, Shimada Y, Yoshimura M, Mondal A, Oda S, Tanaka T, Sakai T, Sakata I (2015-06-26). "Motilin Stimulates Gastric Acid ...
"Identification of mucus glycoprotein fatty acyltransferase activity in human gastric mucosa". Digestion. 32 (1): 57-62. doi: ...
The first stage includes inflammation of the gastric and intestinal mucosa. The second stage is characterized by leukopenia, ... Direct dermal application or oral ingestion of trichothecene causes rapid irritation to the skin or intestinal mucosa. As a ... as well as hemorrhage of the skin and mucosa. If severe, aphonia and death by strangulation can occur. By the fourth stage, ... and chloroplast The lipophilic nature of trichothecenes allow them to be easily absorbed through skin pulmonary mucosa, and gut ...
Bile salt sulfotransferase
2000). "Expression and activity of dehydroepiandrosterone sulfotransferase in human gastric mucosa". J. Steroid Biochem. Mol. ...
The esophageal mucosa (stratified squamous epithelium) is seen on the right. The gastric mucosa (simple columnar epithelium) is ... migration of gastric cardiac cells, and a population of resident embryonic cells present through adulthood. ...
In the stomach, TGF-α is manufactured within the normal gastric mucosa. TGF-α has been shown to inhibit gastric acid secretion ... "Transforming growth factor alpha expression in normal gastric mucosa, intestinal metaplasia, dysplasia and gastric carcinoma-- ... This protein shows potential use as a prognostic biomarker in various tumors, like gastric carcinoma. or melanoma has been ... MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer". ...
"Gene expression changes in patient-matched gastric normal mucosa, adenomas, and carcinomas". Experimental and Molecular ... C11orf86 is down-regulated from non-neoplastic mucosa to adenomas and carcinomas, down-regulated in renal cell carcinoma, and ...
"Biosynthesis in vitro of a sulfated triglucosyl monoalkylmonoacylglycerol by rat gastric mucosa". J. Biol. Chem. 257 (20): ...
"Conversion of gastric mucosa to intestinal metaplasia in Cdx2-expressing transgenic mice". Biochemical and Biophysical Research ... Liu Q, Teh M, Ito K, Shah N, Ito Y, Yeoh KG (Dec 2007). "CDX2 expression is progressively decreased in human gastric intestinal ... Heterozygous CDX2 knock-outs have intestinal lesions caused by the differentiation of intestinal cells into gastric epithelium ... Gastric Cancer. 4 (4): 185-91. doi:10.1007/PL00011741. PMID 11846061. Eda A, Osawa H, Yanaka I, Satoh K, Mutoh H, Kihira K, ...
Prostaglandin EP2 receptor
Takafuji VA, Evans A, Lynch KR, Roche JK (January 2002). "PGE(2) receptors and synthesis in human gastric mucosa: perturbation ... "Activation of prostaglandin E2-receptor EP2 and EP4 pathways induces growth inhibition in human gastric carcinoma cell lines". ...
Imidazopyridine Parisio, C; Clementi, F (November 1976). "Surface Alterations Induced by Stress in Gastric Mucosa: Protective ...
Jared Diamond bibliography
Clausen, C.; Machen, T. E.; Diamond, J. M. (1982). "Changes in the Cell Membranes of the Bullfrog Gastric Mucosa with Acid ... Trophic control of the intestinal mucosa". Nature. 304 (5921): 18. doi:10.1038/304018a0. PMID 6408482. Diamond, J. M. (1983). " ...
"Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia". Cancer Research ... "Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues". European ...
Trefoil factor 2
2003). "Expression of TFF2 and Helicobacter pylori infection in carcinogenesis of gastric mucosa". World J. Gastroenterol. 9 (5 ... Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer and affect healing of ... The encoded protein inhibits gastric acid secretion. This gene and two other related trefoil family member genes are found in a ... They are stable secretory proteins expressed in gastrointestinal mucosa. ...
Brandi G (Aug 2006). "Urease-positive bacteria other than Helicobacter pylori in human gastric juice and mucosa". Am J ... Gastric bypass procedures such as a duodenal switch and RNY, where the largest acid producing parts of the stomach are either ... For practical purposes, gastric pH and endoscopy should be done in someone with suspected achlorhydria. Older testing methods ... Little is known on the prognosis of achlorhydria, although there have been reports of an increased risk of gastric cancer. A ...
The cancer eventually metastasized to her gastric mucosa, evolving to a terminal stage; thus, whatever treatment proved to be ...
Protease-activated receptor 2
Kawabata A (July 2002). "PAR-2: structure, function and relevance to human diseases of the gastric mucosa". Expert Reviews in ...
Cholecystokinin A receptor
"Cellular expression of CCK-A and CCK-B/gastrin receptors in human gastric mucosa". Regulatory Peptides. 102 (2-3): 101-10. doi: ... Huppi K, Siwarski D, Pisegna JR, Wank S (Feb 1995). "Chromosomal localization of the gastric and brain receptors for ...
Gastric mucosa cells change to resemble intestinal mucosa and may even assume absorptive characteristics. Intestinal metaplasia ... With complete metaplasia, gastric mucosa is completely transformed into small-bowel mucosa, both histologically and ... German surgeon, Georg Ernst Konjetzny noticed that gastric ulcer and gastric cancer are the result of gastric inflammation. ... Colonization of the gastric mucosa with Helicobacter pylori results in the development of chronic gastritis in infected ...
... of the colorectal mucosa; sigmoidoscopy is preferred. ... Gastric lavage. *Bariatric surgery *Adjustable gastric band. * ...
Fluorescence in situ hybridization
"Chromosomal instability in gastric mucosa-associated lymphoid tissue lymphomas: A fluorescent in situ hybridization study using ...
গলবিল - উইকিপিডিয়া
Gastric mucosa *Muscularis mucosa. *Gastric rugae. *Gastric pits. *Gastric gland. *Cardiac glands ...
Depending on the area being treated, this may include the skin, oral mucosa, pharyngeal, bowel mucosa and ureter. The rates of ... When treating liver malignancies and metastases, it is possible for collateral radiation to cause gastric, stomach or duodenal ... Similarly, sweat glands in treated skin (such as the armpit) tend to stop working, and the naturally moist vaginal mucosa is ...
Human digestive system
Gastric lipase secreted by the chief cells in the fundic glands in the gastric mucosa of the stomach, is an acidic lipase, in ... Within its mucosa are millions of embedded gastric glands. Their secretions are vital to the functioning of the organ. ... Gastric acid (informally gastric juice), produced in the stomach plays a vital role in the digestive process, and mainly ... In the stomach the gastric phase of digestion takes place. The food is further broken down by mixing with gastric acid until it ...
Sakamoto, C (2004). "The role of mucoprotective drugs in gastric ulcer treatment: with specific reference to their effects on ... gastritis mucosa". Nippon rinsho. Japanese journal of clinical medicine. 62 (3): 566-70. PMID 15038105. DRUG PROFILE OF NOVAL ...
Zotika mirov - Wîkîpediya
Gastric mucosa *Muscularis mucosa. *Gastric rugae. *Gastric pits. *Gastric gland. *Cardiac glands ...
... ulcers are found commonly in the gastric antrum and the duodenum whereas stress ulcers are found commonly in fundic mucosa and ... It is believed that shunting of blood away from the mucosa makes the mucous membrane ischaemic and more susceptible to injury. ... The ulcerations may be superficial and confined to the mucosa, in which case they are more appropriately called erosions, or ... Patients who develop stress ulcers typically do not secrete large quantities of gastric acid; however, acid does appear to be ...
... coats the oral mucosa mechanically protecting it from trauma during eating, swallowing, and speaking. Mouth soreness is ... The biological effects of salivary EGF include healing of oral and gastroesophageal ulcers, inhibition of gastric acid ... also plays an important physiological role in the maintenance of oro-esophageal and gastric tissue integrity. ... secretion, stimulation of DNA synthesis as well as mucosal protection from intraluminal injurious factors such as gastric acid ...
One characteristic of bacillary dysentery is blood in stool, which is the result of invasion of the mucosa by the pathogen. ... Gastric antral vascular ectasia. *Gastric dumping syndrome. *Gastric volvulus. *Buried bumper syndrome ...
Thirty percent of iodine is distributed in other tissues, including the mammary glands, eyes, gastric mucosa, choroid plexus, ... oral mucosa and the stomach. In the thyroid gland, I-concentration is more progressive, also in the reservoir (from 1% after 30 ...
An example of a proton pump that is not electrogenic, is the proton/potassium pump of the gastric mucosa which catalyzes a ... Humans (and probably other mammals) have a gastric hydrogen potassium ATPase or H+/K+ ATPase that also belongs to the P-type ...
Wang K, Xie C, Chen D (2014). "Flap endonuclease 1 is a promising candidate biomarker in gastric cancer and is involved in cell ... compared to adjacent mucosa), of which 629 were in known promoter regions of genes. A third study found more than 2,000 ... of gastric cancer-related genes using a cDNA microarray containing novel expressed sequence tags expressed in gastric cancer ... 1,734 CpG islands were heavily methylated in tumors whereas these CpG islands were not methylated in the adjacent mucosa. ...
In the gastrointestinal tract, increased permeability of the mucosa alters the microflora, causing mucosal bleeding and ... Medication to prevent deep vein thrombosis and gastric ulcers also may be used. ...
Upper gastrointestinal series
Barium contrast is more sensitive in the demonstration of subtle mucosa and sub-mucosa abnormalities but computer tomography is ... Metoclopramide is sometimes also added to the mixture to enhance gastric emptying. X-ray images are then taken in a supine ... and atrophy of the overlying mucosa. Schistosomiasis caused by infection with flatworms have an appearance resembling ...
"Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa". ... "Effects of buffered and plain acetylsalicylic acid formulations with and without ascorbic acid on gastric mucosa in healthy ... Blockade of COX-1 by aspirin apparently results in the upregulation of COX-2 as part of a gastric defense and that taking ... Konturek PC, Kania J, Hahn EG, Konturek JW (November 2006). "Ascorbic acid attenuates aspirin-induced gastric damage: role of ...
Gastric and duodenal ulceration may also occur. Esophageal cancer, a meta-analysis concluded that bisphosphonate treatment is ... Both these drugs have the potential to irritate the upper gastro-intestinal mucosa. Prophylaxis of osteoporosis in women: 5-10 ... The combination of NSAIDs and alendronate may increase the risk of gastric ulcers. ...
The pink color of the esophageal mucosa contrasts to the deeper red of the gastric mucosa, and the mucosal transition ... Reducing gastric reflux. The stomach produces gastric acid, a strongly acidic mixture consisting of hydrochloric acid ( ... and the z-line coincides with the upper limit of the gastric folds of the cardia; however, when the anatomy of the mucosa is ... The mucosa is a stratified squamous epithelium of around three layers of squamous cells, which contrasts to the single layer of ...
The digestion products are then absorbed through the intestinal mucosa into the blood. The intestine ends via the large ... The gastric juices (hydrochloric acid and pepsinogen) are mixed with the stomach contents through the muscular contractions of ... "Gastric digestion of protein through pancreozyme action optimizes intestinal forms for absorption, mucin formation and villus ...
Because this enzyme system is regarded as the acid (proton, or H+) pump within the gastric mucosa, omeprazole inhibits the ... No association is seen between PPI use and cancer, but use of PPIs may mask gastric cancers or other serious gastric problems ... thereby inhibiting the ability of the parietal cells to produce gastric acid. ... suppresses stomach acid secretion by specific inhibition of the H+/K+-ATPase system found at the secretory surface of gastric ...
Syrup of ipecac
They both act locally by irritating the gastric mucosa and centrally by stimulating the medullary chemoreceptor trigger zone to ... Bateman, D N (1999), "Gastric decontamination-a view for the millennium", Emergency Medicine Journal, 16 (2): 84-6, doi:10.1136 ...
Gastric mucosa (Muscularis mucosa, Gastric rugae, Gastric pits, Gastric gland/Cardiac glands/Fundic glands/Pyloric glands) ... Serosa · Subserosa · Muscular layer · Circular folds · Submucosa · Mucosa (Muscularis mucosa, Peyer's patches, Intestinal ...
ICD-10 అధ్యాయము 11: జీర్ణవ్యవస్థకు చెందిన వ్యాధులు - వికీపీడియా
K13) Other diseases of en:lip and en:oral mucosa *(K13.0) Diseases of en:lips *en:Cheilitis ... K31.4) Gastric diverticulum. *(K31.5) Obstruction of duodenum. *(K31.6) Fistula of stomach and duodenum ... K13.4) en:Granuloma and granuloma-like lesions of en:oral mucosa *Verrucous en:xanthoma ...
While TSP is not toxic per se, it is severely irritating to gastric mucosa unless used as part of a buffered solution. ...
阿司匹林 - 維基百科，自由的百科全書
Interaction of a selective cyclooxygenase-2 inhibitor with aspirin and NO-releasing aspirin in the human gastric mucosa. ... 對急性疼痛而言，阿司匹林是一種高效的鎮痛藥，但是通常認為其對疼痛的緩解效果不如布洛芬，因為阿司匹林更容易引發胃腸道出血。 一般情況下，阿司匹林對肌肉抽搐、腹脹（英語：bloating）、胃擴張（英語：gastric distension）和急性皮 ... Effects of buffered and plain acetylsalicylic
The gastric mucosa is pitted with innumerable gastric pits which house the gastric glands. ... The three types of gland are all located beneath the gastric pits within the gastric mucosa-the mucous membrane of the stomach ... Right gastric artery, left gastric artery, right gastro-omental artery, left gastro-omental artery, short gastric arteries. ... Right gastric vein, left gastric vein, right gastroepiploic vein, left gastroepiploic vein, short gastric veins. ...
Chemical - acids, e.g. dietary, gastric, acid etch during dental treatments. ... Oral mucosa - Lining of mouth. *Amalgam tattoo. *Angina bullosa haemorrhagica. *Behçet's disease ...
Kawabata A (2004). "PAR-2: structure, function and relevance to human diseases of the gastric mucosa.". Expert reviews in ...
Carbonic anhydrase 9
... in normal mucosa of large intestine and in colorectal tumors". Digestive Diseases and Sciences. 46 (10): 2179-86. doi:10.1023/A ... and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. ...
Feeding Regulates the Expression of Pancreatic Genes in Gastric Mucosa
... Maria Rita De Giorgio, Mayumi Yoshioka, and Jonny St- ... K. Rokutan, "Role of heat shock proteins in gastric mucosal protection," Journal of Gastroenterology and Hepatology, vol. 15, ... J. Saliba, J. Wattacheril, and N. N. Abumrad, "Endocrine and metabolic response to gastric bypass," Current Opinion in Clinical ... J. G. Moore, P. E. Christian, and J. A. Brown, "Influence of meal weight and caloric content on gastric emptying of meals in ...
Gastric mucosa - Wikipedia
The gastric mucosa is the mucous membrane layer of the stomach, which contains the glands and the gastric pits. In humans, it ... Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric ... Several types of endocrine cells are found in throughout the gastric mucosa. The pyloric glands contain gastrin-producing cells ... These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of ...
Ultrastructural changes in the gastric mucosa in chronic gastritis in children]. - PubMed - NCBI
Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. - PubMed - NCBI
Expression of Melatonin Synthesizing Enzymes in Helicobacter pylori Infected Gastric Mucosa
WikiGenes - Gastric Mucosa
Associations of Gastric Mucosa with chemical compounds. *Role of PGE2 in anion exchange in gastric mucosa . ... Biological context of Gastric Mucosa. *Vasoconstriction with thromboxane A2 induces ulceration of the gastric mucosa . ... Disease relevance of Gastric Mucosa. *The degree of intestinal metaplasia and its macroscopic distribution in gastric mucosa ... Krebs cycle, pentose phosphate pathway, and glycolysis in the uninvolved gastric mucosa of peptic ulcer and gastric cancer ...
Irritation of gastric mucosa Archives - ESCOP
Irritation of gastric mucosa, Irritation of oral and pharyngeal mucosa, Marshmallow root ... Filed Under: Cough, Digestive disorders, Gastritis, Gastrointestinal complaints, Inflammation of the oropharyngeal mucosa, ... Archives for Irritation of gastric mucosa. Irritation of gastric mucosa. Althaeae radix (Marshmallow root) - online ...
Gastric mucosa | definition of gastric mucosa by Medical dictionary
... gastric mucosa explanation free. What is gastric mucosa? Meaning of gastric mucosa medical term. What does gastric mucosa mean? ... Looking for online definition of gastric mucosa in the Medical Dictionary? ... gastric mucosa. Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.. Related to gastric mucosa: gastritis, ... Gastric mucosa , definition of gastric mucosa by Medical dictionary https://medical-dictionary.thefreedictionary.com/gastric+ ...
Wagner-Meissner-Like Corpuscles in Gastric Mucosa: A Brief Report.
... corpuscles are touch receptors that are located in dermal papillae and are usually absent in gastrointestinal mucosa. Wagner- ... A case of Wagner-Meissner-like corpuscles in endoscopically normal gastric mucosa biopsy of a 48-year-old woman is presented ... From a review of the literature, only 2 cases of tactile corpuscle-like structures in gastric mucosa are available.. ... corpuscles are touch receptors that are located in dermal papillae and are usually absent in gastrointestinal mucosa. Wagner- ...
The gastric mucosa in anaemia in Punjabis | Gut
Helicobacter pylori eradication for premalignant lesions of the gastric mucosa | Cochrane
Helicobacter pylori eradication for premalignant lesions of the gastric mucosa. To assess the effect of Helicobacter pylori ... Helicobacter pylori eradication for premalignant lesions of the gastric mucosa. Cochrane Database of Systematic Reviews 2007, ... eradication therapy on different stages of premalignant lesions of the gastric mucosa, i.e. atrophic gastritis, intestinal ...
Immunolocalization of Cholecystokinin-2 Receptors in Rat Gastric Mucosa
BACKGROUND: Gastrin exerts trophic effects on the gastric mucosa by mechanisms not yet completely elucidated. Our aim was to ... Immunolocalization of Cholecystokinin-2 Receptors in Rat Gastric Mucosa. Tømmerås, Karin Linköping University, Department of ... Thus, collagen type I, which is overexpressed in gastric ulcers and gastric cancers, likely stimulates proliferation of mucus- ... RESULTS: Undifferentiated foetal gastric epithelial cells expressed CCK2 receptors, whereas stem cells of adult gastric glands ...
Clinical study on the piweiping capsule in treating patients with metaplasia of gastric mucosa]
One hundred and forty-three patients were diagnosed as chronic superficial atrophic gastritis of gastric antrum or with ... Clinical study on the piweiping capsule in treating patients with metaplasia of gastric mucosa] Zhongguo Zhong Xi Yi Jie He Za ... the improvement of gastric mucosa cyclic adenosine monophosphate, deoxyribonucleic acid, 3H-thymopyrimidine nucleoside and ... One hundred and forty-three patients were diagnosed as chronic superficial atrophic gastritis of gastric antrum or with ...
Nitric oxide synthase in gastric mucosa. | Gut
Characterization of oxyntic glands isolated from the rat gastric mucosa
A simple and reproducible method for isolating oxyntic glands from the rat gastric mucosa was developed. The mucosa was ... The design of methods useful for the preparation of viable glands and cells from the gastric mucosa allowed detailed studies on ... Characterization of oxyntic glands isolated from the rat gastric mucosa. Azerkan, Leila Linköping University, Department of ... A method useful for the study of rat gastric glands was developed. The viability of the rat gastric glands appeared excellent ...
Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa | Cancer Research
... in the DNA of human gastric mucosa with and without H. pylori infection. Gastric antral biopsies were taken from pediatric ... Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa. Seung-Chul Baik, Hee-Shang Youn, Myung-Hee ... Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa. Seung-Chul Baik, Hee-Shang Youn, Myung-Hee ... Increased Oxidative DNA Damage in Helicobacter pylori-infected Human Gastric Mucosa. Seung-Chul Baik, Hee-Shang Youn, Myung-Hee ...
Effect of stimulation of cholinergic muscarinic receptors on norepinephrine accumulation in esophageal and gastric mucosa in...
An hour and half after injection of norepinephrine its concentration in the mucosa of the lesser curvature of the stomach ... Selective norepinephrine accumulation in the mucosa of the esophagus and lesser gastric curvature is apparently due to its high ... Effect of stimulation of cholinergic muscarinic receptors on norepinephrine accumulation in esophageal and gastric mucosa in ... catecholamines esophageal mucosa stomach Translated fromByulleten Eksperimentalnoi Biologii i Meditsiny, Vol. 125, No. 4, pp ...
Gastric Pit Dysplasia in Adjacent Gastric Mucosa in 414 Gastric Cancers
"Gastric Pit Dysplasia in Adjacent Gastric Mucosa in 414 Gastric Cancers." The American Journal of Surgical Pathology 35 (7) ( ... We have found that 21.0% (n=87) of gastric cancer cases showed pit dysplasia in adjacent gastric mucosa. Gastric cancers with ... We have evaluated the surrounding gastric mucosa of 414 gastric cancers for the presence of gastric pit dysplasia. We ... We suggest that gastric pit dysplasia is an important candidate precursor of gastric adenocarcinoma and may represent another ...
Factors Affecting Glycoprotein Synthesis in the Rat Gastric Mucosa | Biochemical Society Transactions | Portland Press
Factors Affecting Glycoprotein Synthesis in the Rat Gastric Mucosa BRIAN JOHNSTON; BRIAN JOHNSTON ... BRIAN JOHNSTON, ANDREW M. SYMONS, DENNIS V. PARKE; Factors Affecting Glycoprotein Synthesis in the Rat Gastric Mucosa. Biochem ... High α-tocopherol dosing increases lipid metabolism by changing redox state in damaged rat gastric mucosa and liver after ... Digestion of Gluten Peptides by Normal Human Jejunal Mucosa and by Mucosa from Patients with Adult Coeliac Disease Clin Sci ( ...
Changes in proliferation of epithelial cells of the gastric mucosa in mice with experimental gastric erosions and ulcers |...
Public Health Epithelial Cell Gastric Mucosa Gastric Erosion Laboratory of Cytology, Institute of Medical Genetics, Academy of ... Changes in proliferation of epithelial cells of the gastric mucosa in mice with experimental gastric erosions and ulcers. ... T. B. Timashkevich, The Mitotic Regime in the Gastric Mucosa of Rats, Candidates Dissertation, Moscow (1967).Google Scholar ...
The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae
Helicobacter pylori infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed ... Noncancerous gastric mucosae were collected from 4 groups of individuals (with and without a gastric cancer, and with and ... The presence of a methylation fingerprint of Helicobacter pylori infection in human gastric mucosae Int J Cancer. 2009 Feb 15; ... Helicobacter pylori infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed ...
Influence of Helicobacter Pylori Infection Persistence on bcl-2 Expression in Gastric Mucosa Inflammatory Cells
... pylori infection is an etiological factor related to gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT ... Chronic Helicobacter (H.) pylori infection is an etiological factor related to gastric adenocarcinoma and gastric mucosa- ... The gastric mucosa samples were analyzed histologically in both groups of patients before and after standard therapy (for ... Influence of Helicobacter Pylori Infection Persistence on bcl-2 Expression in Gastric Mucosa Inflammatory Cells. Acta clinica ...
New spiral bacterium in gastric mucosa. | Journal of Clinical Pathology
Bile reflux and intestinal metaplasia in gastric mucosa. | Journal of Clinical Pathology
METHOD: A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from ... The positive associations with atrophy and intestinal metaplasia have implications for models of gastric carcinogenesis. ... AIM: To determine associations between enterogastric bile reflux and gastric mucosal pathology. ...
Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated...
Regression of primary gastric lymphoma of mucosa-associated lymphoid tissue type after cure of Helicobacter pylori infection. ... Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated ... Helicobacter pylori is linked to development of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (3, 10); however, the ... Frequency of vacA Genotypes and Cytotoxin Activity in Helicobacter pylori Associated with Low-Grade Gastric Mucosa-Associated ...
Gastric mucosa Vector Clip Art Illustrations. 82 Gastric mucosa clipart EPS vector drawings available to search from thousands...
Over 82 Gastric mucosa pictures to choose from, with no signup needed. Download in under 30 seconds. ... gastric acidity Clip Art Vectorby rob30001/21. Gastric mucosa in polypous gastritis. Infographics. Vector illustration on ... Gastric mucosa with hypertrophic gastritis. Infographics. Vector illustration on isolated background Vector Illustrationby ... Cells that form the gastric juice, vintage engraving. EPS Vectorby Morphart0/10. Helicobacter pylori. Helicobacter pylori of ...
Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after Helicobacter pylori Eradication |...
Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after Helicobacter pylori Eradication ... Pinotti G, Chini C, Capella C. Most Gastric Low-Grade B-Cell Lymphomas of Mucosa-Associated Lymphoid Tissue Persist after ... Eradication ofHelicobacter pylori may induce remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma ( ... Five patients had multifocal disease, and anatomic gastric site changed in 3 patients. Disease did not progress to advanced ...
Up-Regulation of IL-17 Is Associated with Bioactive IL-8 Expression in Helicobacter pylori-Infected Human Gastric Mucosa | The...
IL-17 RNA transcripts are increased in the gastric mucosa of Hp-infected patients, RNA was extracted from whole mucosal gastric ... IL-17 produced in the gastric mucosa of Hp-infected patients is biologically active. The demonstration that gastric LPMC ... To further substantiate the role of IL-17 in the induction of IL-8 in gastric mucosa, we tested the effect of rhIL-17 on ... In conclusion, we report an increased expression of T cell-derived IL-17 in the gastric mucosa of patients with Hp infection, ...
Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case | The Journal of the American...
Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case You will receive an email whenever ... Lawson R. Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case. J Am Osteopath Assoc 1968; ... Thoracoabdominal duplication cyst containing heterotopic gastric mucosa: report of a case. The Journal of the American ...
Epidermal Growth Factor Stimulates Synthesis and Secretion of Mucus Glycoproteins in Human Gastric Mucosa | Clinical Science |...
Epidermal Growth Factor Stimulates Synthesis and Secretion of Mucus Glycoproteins in Human Gastric Mucosa S. M. Kelly; S. M. ... Effects of alloxan-induced diabetes on somatostatin binding to cytosolic components of rabbit gastric fundic mucosa Biosci Rep ... 1. The effects of epidermal growth factor on the synthesis and secretion by human gastric mucosa of radiolabelled mucus ... Epidermal Growth Factor Stimulates Synthesis and Secretion of Mucus Glycoproteins in Human Gastric Mucosa. Clin Sci (Lond) 1 ...
GastritisMucosalNormal gastric mucosaMetaplasiaSecretionGlandsEpitheliumCarcinogenesisEpithelial cellsLamina propriaUlcerLymphoid tissue lymphomaHuman gastricCarcinomaPathologyStomachInfectionMRNABiopsyHelicobacter pylori Infected Gastric MucosaHeterotopic gastricPathogenesisAbstractHistologicalEsophagusLymphomaEffect on the gastric mucosaChanges in the gastric mucosaEndoscopicUlcerationDevelopment of gastric cancerInflammationDuodenalAdenocarcinomaEctopic gastric mucosaGastrointestinalRabbit gastricBiopsiesRatsInflammatoryAcidGenesDiseasesHemorrhageCancerMucusDyspepsiaCancersHistamineEthanolSpecimensParietalPatientsTissuesDysplasiaNitric oxide sy
- Ultrastructural changes in the gastric mucosa in chronic gastritis in children]. (nih.gov)
- Studying a series of 30 children with chronic gastritis (diagnosed by optic fiber gastroscopy and by mucosal biopsy), authors have founded important changes of the superficial mucosa and gastric glands. (nih.gov)
- To assess the effect of Helicobacter pylori eradication therapy on different stages of premalignant lesions of the gastric mucosa, i.e. atrophic gastritis, intestinal metaplasia and dysplasia. (cochrane.org)
- One hundred and forty-three patients were diagnosed as chronic superficial atrophic gastritis of gastric antrum or with metaplasia by means of gastroscopic observation with pathological biopsy examination. (nih.gov)
- Despite wide acceptance of the chronic gastritis-intestinal metaplasia-dysplasia-carcinoma sequence, especially for intestinal-type gastric adenocarcinoma, the precise nature of the subtle precursor lesions of gastric cancer remains to be delineated. (harvard.edu)
- We investigated its relationship with various clinicopathological and immunophenotypic features of gastric adenocarcinoma, as well as the severity and extent of any surrounding gastritis and intestinal metaplasia. (harvard.edu)
- The aim of this study was to evaluate bcl-2 expression in inflammatory cells in lamina propria in gastric biopsy samples collected from two groups of patients with chronic gastritis divided on the basis of the success or failure of H. pylori eradication. (srce.hr)
- The vacA genotypes s1,m1 and s1,m2 were detected in 44 and 30% of Helicobacter pylori isolates, respectively, from patients with gastric mucosa-associated lymphoid tissue lymphoma, compared to 26 and 56% of isolates, respectively, from individuals with gastritis. (asm.org)
- median age, 60 years) with low-grade gastric MALT lymphoma (stage EI 1 ) compared with H. pylori isolates from 27 age- and sex-matched symptomatic individuals with simple gastritis and no history of peptic ulcer or gastric malignancy. (asm.org)
- Gastric mucosa in polypous gastritis. (canstockphoto.com)
- Gastric mucosa with hypertrophic gastritis. (canstockphoto.com)
- Conclusion: Moderate to marked gastric mucosa inflammation in gallstone patients is mainly caused by Hp infection, whereas gallbladder function is not related to the degree of gastritis. (uni-muenchen.de)
- 1988) Gastritis in the rectum: campylobacterlike organisms in heterotopic inflamed gastric mucosa. (springer.com)
- The biological development of GC in the gastric mucosa (GM) is characterized by the sequence: chronic inflammation-atrophic gastritis (AG)-dysplasia-GC. (morebooks.de)
- however, little is known about the exact histological features of bile reflux and its contributions to gastric mucosal lesions in this disease, especially in children with primary bile reflux gastritis (BRG). (springermedizin.de)
- Autoimmune gastritis is an organ-specific autoimmune disease characterised by type A chronic atrophic gastritis and circulating autoantibodies to gastric parietal cells and intrinsic factor. (arodia.com)
- Helicobacter pylori (H.pylori) has causal role of histologic gastritis, gastro-duodenal ulcer and gastric carcinoma. (nii.ac.jp)
- Forty H.pylori positive histologic gastritis and 34 gastric ulcer tissues were studied. (nii.ac.jp)
- Normal gastric mucosa, intestinal metaplasia, chronic gastritis, and carcinoma could generally be identified from the smears. (mysciencework.com)
- ETHNOPHARMACOLOGICAL RELEVANCE: Helicobacter pylori infection is associated with gastritis, peptic ulcer, and gastric cancer. (isharonline.org)
- Helicobacter pylori (Hp) is a pathogen which causes gastric diseases from gastritis to ulcer, cancer, and MALT Lymphoma. (europeanreview.org)
- Helicobacter pylori is one of the most prevalent human pathogens, contributing to some gastrointestinal related diseases such as gastritis, peptic ulcer, and gastric cancer ( 1 ). (kowsarpub.com)
- Notably, CagA is presented in approximately 60% of H. pylori strains, which promotes severe gastritis, ulcer, and gastric cancer. (kowsarpub.com)
- Nineteen dogs showed mild to marked gastritis in the fundus, and only one dog had a healthy gastric mucosa . (bvsalud.org)
- NHPH DNA was detected in 18 dogs with gastritis and one with normal gastric mucosa . (bvsalud.org)
- Diecinueve perros mostraron gastritis leve a marcada en el fundus gástrico y sólo un perro tuvo una mucosa gástrica sana. (bvsalud.org)
- El ADN de los NHPH fue detectado en 18 perros con gastritis y uno con mucosa gástrica normal. (bvsalud.org)
- Conclusions: This study revealed that smoking may increase the prevalence of having gastric intestinal metaplasia, erosive gastritis, glandular atrophy and reactive gastropathy in H. pylori-positive Egyptian patients. (scirp.org)
- Chronic H . infection Pylori activates the immune response of the host, induces active chronic inflammation and damage to the mucosa, giving rise to multifocal atrophic gastritis, glandular dysplasia, intestinal metaplasia and adenocarcinoma . (scirp.org)
- Immunohistochemical analysis showed high NGAL/Lcn2 expression in normal and gastritis-affected mucosa compared to low expression in intestinal metaplasia, dysplasia, and gastric cancer. (ucr.ac.cr)
- In normal and gastritis-affected mucosa (n = 36 tissue samples), NGAL/Lcn2 was more frequently seen in epithelial cells located at the neck and base of the glands in H. pylori-positive cases than in similar epithelial cells of noninfected cases (Fisher's exact test, p = 0.04). (ucr.ac.cr)
- In conclusion, the high expression of NGAL/Lcn2 in normal and gastritis-affected mucosa infected with H. pylori suggests that NGAL/Lcn2 is upregulated locally in response to this bacterial infection. (ucr.ac.cr)
- Based on this multidimensional imaging technique, we performed a systematic investigation on fresh human tissue specimens at the typical stages of gastric carcinogenesis, including normal, chronic gastritis with erosion, chronic gastritis with intestinal metaplasia, and intestinal-type adenocarcinoma. (osapublishing.org)
- K. Rokutan, "Role of heat shock proteins in gastric mucosal protection," Journal of Gastroenterology and Hepatology , vol. 15, pp. (hindawi.com)
- The 8-hydroxydeoxyguanosine content of the gastric mucosal DNA was measured after H. pylori -positive and H. pylori -negative volunteers were identified. (aacrjournals.org)
- AIM: To determine associations between enterogastric bile reflux and gastric mucosal pathology. (bmj.com)
- We showed that both IL-17 RNA transcripts and protein were expressed at a higher level in the whole gastric mucosal and lamina propria mononuclear cell samples from Hp -infected patients than in those from uninfected subjects. (jimmunol.org)
- Under ME in combination with NBI, a non-structural area, ie, complete or almost-complete disappearance of gastric crypt epithelium and abnormal mucosal capillary pattern was identified ( Fig 1a ). (hkmj.org)
- Because, in other tissues, VEGF is one of the most potent angiogenic factors and VEGF expression is dependent on Ras, our data indicate that Ras and VEGF are involved in gastric mucosal angiogenesis after ethanol injury. (physiology.org)
- Endothelial cells lining gastric mucosal microvessels are major and early targets of acute injury by ethanol ( 34 , 37 , 41 ). (physiology.org)
- Although our knowledge regarding the mechanisms of gastric mucosal injury and restitution of the surface epithelium has advanced rapidly in recent years ( 3 , 19 , 26 , 33 , 38 ), repair of the microvascular network has not been explored except in our previous experiments. (physiology.org)
- Johannesson KA, Hammar E, Stael von Holstein C: Mucosal changes in the gastric remnant: long-term effects of bile reflux diversion and helicobacter pylori infection. (springermedizin.de)
- Also, endoscopic mucosal resection, which conserves the noncancerous gastric mucosae, is becoming popular, and the problem of metachronous gastric cancer recurrence is being recognized ( 3 ). (aacrjournals.org)
- Our results confirm that H. pylori infection can alter the expression of mir-21 in gastric epithelial cells and gastric mucosal tissues. (kowsarpub.com)
- Gastric mucosal cells in patients who are negative for H. pylori express RAS components at low levels (Fig. 2).21 In contrast, H. pylori infection is characterized by marked neutrophil, lymphocyte, monocyte and plasma cell infiltration of gastric mucosa,22 with inflammatory cell numbers closely correlated with increased AT1R and AT2R expression in humans and in a Mongolian gerbil model (Fig. 3a). (mi-rna.com)
- A gastric mucosal injury model was established by giving the rats alcohol. (journaldatabase.info)
- Expression of ATP synthase (ATPase) subunits 6 and 8 in mitochondrial DNA (mtDNA) was determined by reverse transcription polymerase chain reaction (RT-PCR).RESULTS: The gastric mucosal lesion index was correlated with the MDA content in gastric mucosa. (journaldatabase.info)
- In this study, diabetic rats showed a progressive increase in the stomach advanced glycated end products formation, gastric mucosal tumour necrosis factor-α and Thiobarbituric acid reactive substances levels as compared to normal control (nondiabetic) rats. (newsnaturally.com)
- There was decrease in gastric mucosal content, antioxidant enzymes and cellular ATPase enzyme levels of diabetic gastric mucosa when compared to the normal control group. (newsnaturally.com)
- Objective: The main goal of this study was to evaluate the synergistic effect of smoking and H. pylori infection on gastric mucosal among dyspeptic Egyptian patients. (scirp.org)
- Helicobacter pylori is a gram-negative microaerophilic bacillus likely to be placed in the deep sections of the mucosal gel over the gastric mucosa or even between the mucous layer and the epithelium of the stomach . (scirp.org)
- Inducible-type nitric oxide synthase (iNOS) is thought to participate in not only the inflammatory response, but also in the regulation of gastric mucosal cell turnover in H. pylori-colonized gastric mucosa. (elsevier.com)
- Gastric mucosal accumulation of polymorphonuclear leukocytes (PMN) was assessed by determining the myeloperoxidase (MPO) activity and histological score based on the updated Sydney system. (elsevier.com)
- While gastric mucosal PMN infiltration increased following SS1 inoculation in both iNOS +/+ and iNOS -/- strains, enhanced DNA fragmentation was observed in only SS1-colonized iNOS +/+ mice, and not in the iNOS -/- mice. (elsevier.com)
- This condition is usually incidentally detected by endoscopy or biopsy and manifests at the gastric mucosal inlet. (biomedcentral.com)
Normal gastric mucosa6
- A case of Wagner-Meissner-like corpuscles in endoscopically normal gastric mucosa biopsy of a 48-year-old woman is presented here. (biomedsearch.com)
- Intracellular localization of individual isoenzymes of NOS was detected in normal gastric mucosa. (nus.edu.sg)
- The expression of the endothelial NOS, neuronal NOS and inducible NOS in the tumor tissue was significantly lower than in normal gastric mucosa (P = 0.01, P = 0.02, P (nus.edu.sg)
- Loss of glandular architecture, erosions and infiltration of inflammatory cells within the lamina propria compared with normal gastric mucosa were scrutinized.Definite histologic changes and the evidence of H. pylori colonization were observed in the H. pylori infected group.Significant infiltration of inflammatory cells was observed 6 weeks after the last inoculation and the level of serum IgG against H. pylori was increased from 2 weeks after the last inoculation. (nih.gov)
- Loss of glandular architecture, erosions and infiltration of inflammatory cells within the lamina propria compared with normal gastric mucosa were scrutinized. (nih.gov)
- In addition to all the rabbits of the control group, 14 rabbits (35) of the experimental group had normal gastric mucosa. (ac.ir)
- Carcinoma arising from areas of intestinal metaplasia in the gastric mucosa. (nih.gov)
- These results suggested that the PWPC could reverse the intestinal metaplasia through improving the gastric cAMP, DNA and strengthening the cellular immunity and the effect would be enhanced when the treatment was based on syndrome differentiation. (nih.gov)
- Interestingly, gastric mucin-containing intestinal metaplasia (incomplete intestinal metaplasia) was highly associated with adenocarcinoma with pit dysplasia (P=0.000). (harvard.edu)
- Bile reflux and intestinal metaplasia in gastric mucosa. (bmj.com)
- The positive associations with atrophy and intestinal metaplasia have implications for models of gastric carcinogenesis. (bmj.com)
- Gastric Metaplasia in Duodenal Mucosa - Key Factor for H. pylori Colonization and Duodenal Ulcer Pathogenesis? (springer.com)
- Carrick J, Lee A, Hazell S, Ralston M, Daskalopoulos G (1989) Campylobacter pylori, duodenal ulcer, and gastric metaplasia: possible role of functional heterotopic tissue in ulcerogenesis. (springer.com)
- Wyatt JI, Rathbone BJ, Dixon MF, Heatley RV (1987) Campylobacter pyloridis and acid induced gastric metaplasia in the pathogenesis of duodenitis. (springer.com)
- Shousha S, Parkins RA, Bull TB (1983) Chronic duodenitis with gastric metaplasia: electron microscopic study including comparison with normal. (springer.com)
- CagA promotes an intestinal stem/progenitor-like state and related, and that eradication therapy helps to prevent 1155 thereby is implicated in intestinal metaplasia of the gastric metachronous gastric carcinogenesis. (bestatin.top)
- The risk of gastric cancer is greatest in those with non-ulcer dyspepsia, or gastric ulceration, who develop gastric atrophy and intestinal metaplasia with long term H. pylori infection [ 3 ]. (mdpi.com)
- The design of methods useful for the preparation of viable glands and cells from the gastric mucosa allowed detailed studies on the mechanisms that regulate gastric acid secretion. (diva-portal.org)
- The addition of a neutralizing anti-IL-17 Ab to the gastric lamina propria mononuclear cell cultures resulted in a significant inhibition of IL-8 secretion, indicating that IL-17 contributes to enhance IL-8 in the Hp -colonized gastric mucosa. (jimmunol.org)
- Consistently, stimulation of MKN 28 cells, a gastric epithelial cell line, with IL-17 increased IL-8 secretion. (jimmunol.org)
- 1. The effects of epidermal growth factor on the synthesis and secretion by human gastric mucosa of radiolabelled mucus glycoprotein have been studied in organ culture. (portlandpress.com)
- Patrick WJA, Denham D, Forrest PM (1974) Mucous changes in the human duodenum: a light and electron microscopic study and correlation with disease and gastric acid secretion. (springer.com)
- 1. The sugars and amino sugars of hydrolysates of gastric secretion were determined by gas-liquid chromatography. (biochemj.org)
- Results of a study are reported of a study of the concentration of biologically active substances such as histamine, serotonin, noradrenaline, adrenalin, corticotropin and indices of gastric secretion in ulcer disease patients at the stage of exacerbation receiving microwave resonance therapy and hypnotherapy. (isharonline.org)
- It was once believed that tumors of ECL origin form after a prolonged inhibition of gastric acid secretion, however there is no data to support this conclusion and proton pump inhibitors are not thought to contribute to gastric cancer [ citation needed ] . (wikipedia.org)
- Secretion of gastric acid or alkaline pancreatic juice from the ectopic mucosa leads to ulceration in the adjacent ileal mucosa i.e. peptic or pancreatic ulcer. (wikipedia.org)
- The gastric mucosa is the mucous membrane layer of the stomach, which contains the glands and the gastric pits. (wikipedia.org)
- These are the ducts of the gastric glands, and at the bottom of each may be seen one or more minute orifices, the openings of the gland tubes. (wikipedia.org)
- Gastric glands are simple or branched tubular glands that emerge on the deeper part of the gastric foveola, inside the gastric areas and outlined by the folds of the mucosa. (wikipedia.org)
- Undifferentiated foetal gastric epithelial cells expressed CCK2 receptors, whereas stem cells of adult gastric glands did not exhibit immunoreactivity. (diva-portal.org)
- However, other epithelial cells in the progenitor zone of adult gastric glands did express CCK2 receptors. (diva-portal.org)
- These undifferentiated cells and also presumably immature epithelial cells in the progenitor zone of adult gastric glands were shown to express cholecystokinin-2 (CCK 2 ) receptors and are therefore targets for the trophic action of gastrin. (diva-portal.org)
- A simple and reproducible method for isolating oxyntic glands from the rat gastric mucosa was developed. (diva-portal.org)
- The mucosa was incubated with pronase and EGTA, and then treated mechanically to release glands that were separated from single cells by sedimentation. (diva-portal.org)
- The preparation of rabbit gastric glands was the first suitable method to be used and a number of important scientific contributions have been accomplished with this method. (diva-portal.org)
- We also developed a method for the study of viable rat gastric glands that allowed comparative studies in the rat species. (diva-portal.org)
- In rabbit gastric glands CCK-like pep tides inhibited histamine stimulated acid formation whereas gastrin peptides were ineffective. (diva-portal.org)
- Parietal cell of stomach wall, located in the gastric glands secretes hydrochloric acid. (canstockphoto.com)
- Parietal cell secreting hydrochloric acid and intrinsic factor, located in the stomach gastric glands. (canstockphoto.com)
- Enterochromaffin-like cells or ECL cells are a type of neuroendocrine cell found in the gastric glands of the gastric mucosa beneath the epithelium , in particular in the vicinity of parietal cells , that aid in the production of gastric acid via the release of histamine . (wikipedia.org)
- Histological analysis showed that the resected cyst was walled by hyperplastic, fibrous tissues and locally lined with gastric mucosa inherent glands. (biomedcentral.com)
- It consists of simple columnar epithelium, lamina propria, and the muscularis mucosae. (wikipedia.org)
- An important iodine concentration by sodium-iodide symporter (NIS) is present in mucinous cells of surface epithelium and gastric pits of the fundus and pyloric part of the stomach. (wikipedia.org)
- The mechanisms regulating the proliferation and differentiation processes that give rise to and maintain the gastric epithelium have not yet been completely elucidated. (diva-portal.org)
- Surface mucus cells (SMCs) of the gastric epithelium are the target cells for H. pylori colonization . (springer.com)
- Wolff M (1971) Heterotopic gastric epithelium in the rectum. (springer.com)
- James AG (1964) Gastric epithelium in the duodenum. (springer.com)
- Monoclonal antibodies to the H+-K+ ATPase of gastric mucosa selectively stain the non-pigmented cells of the rabbit ciliary body epithelium. (arvojournals.org)
- Monoclonal antibodies developed against the transport enzyme H+-K+ ATPase of gastric mucosa selectively bind to the nonpigmented cell layer in both the pars plana and pars plicata of the rabbit ciliary body epithelium. (arvojournals.org)
- Publications] Chiba M,Ishii N,Ishioka T,Murata M,Masamune O,Sugiyama T,Yachi A.: 'Topographic study of Helicobacter pylori and HLA-DR antigen expression on gastric epithelium. (nii.ac.jp)
- Cross-section of the gastric or stomach epithelium showing the numerous gastric pits on the surface of the mucosa. (gettyimages.it)
- Ectopic gastric epithelium is common in the cervical esophagus . (bvsalud.org)
- Gastrin is transferred from a specific type of G cell in the gastric epithelium to the ECL cells by blood . (wikipedia.org)
- Ectopic GI mucosa of the esophagus is thought to result from the reduced replacement of simple column epithelium by stratified squamous epithelium during esophageal embryogenesis. (biomedcentral.com)
- A plausible hypothesis for the missing link between H. pylori infection and gastric carcinogenesis involves oxygen free radical-induced DNA damage. (aacrjournals.org)
- Although aberrant DNA methylation is deeply involved in gastric carcinogenesis, its induction by Helicobacter pylori , a strong gastric carcinogen, is unclear. (aacrjournals.org)
- Publications] Sugiyama T: 'Relationship of H.pylori to gastric carcinogenesis' Ann Cancer Res Ther. (nii.ac.jp)
- Thus, the present study provides important insights into the mechanisms underlying gastric carcinogenesis in H pylori-infected gastric mucosa, which can be used to prevent de novo development and metachronous recurrence of gastric cancer. (bestatin.top)
- Our data show that DNA methylation accumulation is associated with molecular irreversibleness and gastric carcinogenesis after H. pylori eradication. (fujita-hu.ac.jp)
- Deregulated cell turnover in Helicobacter pylori (H. pylori)-colonized gastric mucosa has been suggested to be linked to the gastric carcinogenesis pathway. (elsevier.com)
- Our findings are consistent with the hypothesis that a CCK2 receptor mediates direct effects of gastrin on gastric epithelial cells during both stomach organogenesis and adult life. (diva-portal.org)
- Pentagastrin and hydrocortisone were found to accelerate the development of H,KTPase-positive parietal cells and other epithelial cells from undifferentiated gastric epithelial cells of foetal rats. (diva-portal.org)
- Eight of 34 gastric ulcer tissues (23.5%) had HSP expression on the epithelial cells. (nii.ac.jp)
- HSP is a cross-reactive protein between H.pylori organisms and H.pylori infected gastric epithelial cells. (nii.ac.jp)
- ll properties in CAPZA1- therapy is important to prevent the development of gastric 1164 overexpressing gastric epithelial cells. (bestatin.top)
- EHF virus antigen exists in epithelial cytoplasm of the superficial layer and lamina propria of gastric mucosa and the virus is dissociated from gastric mucosa. (curehunter.com)
- In these animals, the gastric lamina propria was infiltrated with lymphoid cells organized in follicles composed of B cells with few infiltrating T cells. (inserm.fr)
- caused by gastric ulcer or foreign body. (thefreedictionary.com)
- Enhanced gastric nitric oxide synthase activity in duodenal ulcer patients. (bmj.com)
- Restrained water immersion stress of 30 min (WRS) in mice and rats caused mild ulcer in the gastric mucosa. (nii.ac.jp)
- Possible involvement of tissue-type plasminogen activator in gastric ulcer formation. (elsevier.com)
- Methods - In this retrospective case control study, the phenotype of the gastric mucosa was histologically characterised in 53 consecutive patients with Barrett's oesophagus and in 53 (sex and age matched) non-ulcer dyspeptic controls. (elsevier.com)
Lymphoid tissue lymphoma10
- Gastric mucosa-associated lymphoid tissue lymphoma is uncommon and most patients have an indolent clinical course. (hkmj.org)
- We describe herein the case of a 64-year-old woman with Helicobacter pylori -negative gastric mucosa-associated lymphoid tissue lymphoma diagnosed by screening magnification endoscopy. (hkmj.org)
- The use of magnification endoscopy in gastric mucosa-associated lymphoid tissue lymphoma and its management are reviewed. (hkmj.org)
- The favorable response rate of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication has been demonstrated. (ovid.com)
- The aim of this retrospective study was to evaluate the long-term outcomes of radiotherapy for localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication. (ovid.com)
- Thirty-four consecutive patients with localized gastric mucosa-associated lymphoid tissue lymphoma that were refractory to eradication were treated with radiotherapy (a total dose of 30 Gy). (ovid.com)
- Pathologically, all three recurrences revealed mucosa-associated lymphoid tissue lymphoma without any transformation to high-grade lymphoma. (ovid.com)
- None died of gastric mucosa-associated lymphoid tissue lymphoma. (ovid.com)
- Radiotherapy in patients with localized gastric mucosa-associated lymphoid tissue lymphoma refractory to Helicobacter pylori eradication can achieve excellent overall survival. (ovid.com)
- Lee, SK 2017, ' Endoscopic findings of gastric extranodal marginal zone B-cell mucosa-associated lymphoid tissue lymphoma ', Clinical Endoscopy , vol. 50, no. 1, pp. 1-2. (elsevier.com)
- To test this hypothesis, we compared the amount of 8-hydroxydeoxyguanosine, a marker for oxygen free radical-induced DNA damage, in the DNA of human gastric mucosa with and without H. pylori infection. (aacrjournals.org)
- Our chief study was conducted to assess the relationship betweenconsumption of honey and apoptosis in human gastric mucosa.Method: This cross-sectional study was conducted on 98 subjects over 18 years old, referred totwo hospitals in Tabriz, Iran. (journaldatabase.info)
- Interaction between Helicobacter pylori and human gastric mucosa revisited by electron microscopy: still something new to debate? (europeanreview.org)
- The aim of the present, preliminary, retrospective, study was to investigate the morphological expression of T4SS also in human gastric biopsies and revisit the morphological aspects of bacteria and host interaction. (europeanreview.org)
- The H. pylori isolated freshly from Korean adults could colonize the stomach of BALB/c mice and induce pathologic alterations that mimics human gastric diseases. (nih.gov)
- It shows strong association with the development of gastric carcinoma. (aacrjournals.org)
- The increased level of oxidative DNA damage suggests the mechanistic link between H. pylori infection and gastric carcinoma. (aacrjournals.org)
- It is also the first bacterium discovered to be involved in the development of malignant diseases: i.e., gastric carcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma ( 14 , 21 , 40 ). (asm.org)
- Superficial spreading carcinoma (SSC) is an unusual form of esophageal cancer in which tumor is confined to the mucosa or submucosa, regardless of the presence or absence of lymph node metastases. (appliedradiology.com)
- Such preneoplastic changes can potentially transform to gastric carcinoma. (ac.ir)
- Methods: We collected data from a large national pathology database of 895,323 subjects who underwent esophagogastroduodenoscopy with gastric biopsies from January 2008 through December 2013 at endoscopy centers throughout the United States. (elsevier.com)
- Reactive gastropathy, which was detected in 18% of biopsies, increased with age and was the second most common factor of gastric pathology observed. (elsevier.com)
- To examine the importance of EGFR signalling to gastric pathology, this study investigated whether treatment of Mongolian gerbils with a selective EGFR tyrosine kinase inhibitor, EKB-569, altered gastric pathology in chronic H. pylori infection. (mdpi.com)
- EGFR inhibition by EKB-569 therefore reduced the severity of pre-neoplastic gastric pathology in chronically H. pylori- infected gerbils. (mdpi.com)
- An hour and half after injection of norepinephrine its concentration in the mucosa of the lesser curvature of the stomach increases and in the greater curvature decreases. (springer.com)
- Primary extranodal low-grade B cell lymphoma of the mucosa-associated lymphoid tissue (MALToma) of stomach is uncommon. (hkmj.org)
- The specific interrelationship (i.e. adhesion) between H. pylori and its gastric target cell is responsible for the unique location of H. pylori in the stomach (antrum and body area) with the only exception of its ectopic localization on metaplastic gastric SMCs in different parts of the gastrointestinal tract. (springer.com)
- The present study investigated the expression and distribution of three isoforms of nitric oxide synthase (NOS) in different anatomical regions of the human stomach and in gastric neoplastic tissues by immunohistochemistry using specific antibodies. (nus.edu.sg)
- The mucosa of the normal stomach is loosely attached to the muscularis and is movable over it. (jamanetwork.com)
- Early identification of premalignant and malignant gastric mucosa is crucial to decrease the incidence and mortality of stomach cancer. (osapublishing.org)
- Helicobacter pylori infection was recently shown to induce aberrant methylation in gastric mucosae, and produce a predisposed field for cancerization. (nih.gov)
- Chronic Helicobacter (H.) pylori infection is an etiological factor related to gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. (srce.hr)
- Inflammatory alterations of the gastric mucosa are commonly caused by Helicobacter pylori (Hp) infection in patients with symptomatic gallstone disease. (uni-muenchen.de)
- Aim:To investigate the relation of gallbladder function and Hp infection to gastric mucosa inflammation in patients with symptomatic gallstones prior to cholecystectomy. (uni-muenchen.de)
- Here, we analyzed the effect of H. pylori infection on the quantity of methylated DNA molecules in noncancerous gastric mucosae and examined its association with gastric cancer risk. (aacrjournals.org)
- The major etiologic risk factor for gastric cancers is Helicobacter pylori infection, which increases gastric cancer risk 2.2- to 21-fold ( 4 - 6 ). (aacrjournals.org)
- In an animal model with Mongolian gerbil chronic infection with H. pylori rarely induces gastric cancers by itself, but markedly enhances their incidences after initiation with a mutagen, such as N -methyl- N -nitrosourea ( 7 ). (aacrjournals.org)
- As an additional mechanism of gastric cancer induction by H. pylori infection, induction of aberrant methylation was suggested by Chan et al. (aacrjournals.org)
- 10 ). They observed that E-cadherin methylation was more frequent in the gastric mucosae of dyspepsia cases with H. pylori infection than those without. (aacrjournals.org)
- 11 ) did not observe a difference in the number of methylated genes in gastric mucosae with and without H. pylori infection. (aacrjournals.org)
- Abstract Helicobacter pylori infection plays a crucial role in the pathogenesis of gastric extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT). (inserm.fr)
- Helicobacter pylori colonizes half of the world's population as the dominant member of the gastric microbiota resulting in a lifelong chronic infection. (nimml.org)
- Dendritic cell function in the host response to Helicobacter pylori infection of the gastric mucosa. (docphin.com)
- In this regard, Helicobacter pylori infection is considered as the main risk factor for gastric cancer. (kowsarpub.com)
- Here, H pylori infection overexpressing cells remaining in the gastric mucosa af- 1160 increased mRNA expression of SALL4 and KLF5 in CAPZA1- ter eradication therapy increase the risk of metachronous 1161 overexpressing cells more than in pCMV6-ctrl-transfected gastric cancer and that reduction of CAPZA1 expression by 1162 cells (Figure 2E). (bestatin.top)
- The CAPZA1 expression level correlates with the level of oxidative stress injury induced 1170 by H pylori infection in the gastric mucosa. (bestatin.top)
- Evidence for H. pylori infection was assessed by rapid urease test of gastric mucosa and by microscopic examination using the H & E stain and Warthin-Starry silver stain. (nih.gov)
- Background & Aims: We aimed to characterize age-related changes in the gastric mucosa and investigate the contribution of Helicobacter pylori infection to these changes. (elsevier.com)
- A higher proportion of people in areas with a high prevalence of H pylori infection acquired gastric abnormalities. (elsevier.com)
- Infection with the gastric bacterium Helicobacter pylori is associated with increased risk of developing distal gastric cancer [ 1 , 2 ]. (mdpi.com)
- Marked gastric epithelial hyperplasia with H. pylori infection occurs in both humans and rodent models [ 7 , 8 , 9 , 10 , 11 , 12 ]. (mdpi.com)
- Helicobacter pylori infection is one of the most significant risk factors for gastric cancer. (ucr.ac.cr)
- We have characterized here the pattern of expression of NGAL/Lcn2 in gastric mucosa (45 non-neoplastic and 38 neoplastic tissue samples) and explored the connection between NGAL/Lcn2 expression and H. pylori infection. (ucr.ac.cr)
- Helicobacter pylori infection, particularly with cagA positive strains, induces inflammatory/atrophic lesions of the gastric mucosa, which may impair acid output. (elsevier.com)
- Molecular irreversibleness with Helicobacter pylori (H. pylori) infection might have a role in gastric tumorigenesis after H. pylori eradication. (fujita-hu.ac.jp)
- Using four different groups of biopsies obtained from gastric body without history of H. pylori infection (Hp-), gastric body without cancer after H. pylori eradication (cancer-free body), gastric body with early gastric cancer diagnosed after H. pylori eradication (EGC body) and their paired samples from adjacent mucosa of cancer (EGC ADJ), methylation status of five candidate genes (MYOD1, SLC16A12, IGF2, RORA and PRDM5) was examined by the bisulfite pyrosequencing. (fujita-hu.ac.jp)
- These data suggest that iNOS may play an important role in promoting apoptosis in the H. pylori-infected inflamed gastric mucosa, and that persistent inflammation without apoptosis in iNOS -/- mice with H. pylori infection may be linked to preneoplastic transformation. (elsevier.com)
- Ethanol damage triggered 1 ) angiogenesis in the gastric mucosa bordering necrosis, 2 ) significant increases in VEGF mRNA and protein expression, and 3 ) significant increases in the expression of Ki- ras mRNA and Ras proteins. (physiology.org)
- Quantitative PCR detected HMT mRNA in gastric mucosa, but the expression level did not change by WRS. (nii.ac.jp)
- The expression of mtDNA ATPase subunits 6 and 8 mRNA declined with the increasing MDA content in gastric mucosa after gavage with ethanol.CONCLUSION: Ethanol-induced gastric mucosa injury is related to oxidative stress, which disturbs energy metabolism of mitochondria and plays a critical role in the pathogenesis of ethanol-induced gastric mucosa injury. (journaldatabase.info)
- METHOD: A retrospective study using fasting gastric juice bile acid measurements and antral or prestomal biopsy specimens from 350 patients, 66 of whom had previously undergone surgery that either bypassed or disrupted the pyloric sphincter. (bmj.com)
- Gastric mucosa damage was investigated with techniques of gastroscopy, gastric biopsy, antigen location with immunohistochemical enzyme staining and virus dissociation in 135 patients with epidemic hemorrhagic fever (EHF). (curehunter.com)
Helicobacter pylori Infected Gastric Mucosa2
- Noohi M, Hakemi-Vala M, Nowroozi J , Fatemi S R, Dezfulian M . Evaluation of miR-21 Expression Level in Helicobacter pylori -Infected Gastric Mucosa, Jundishapur J Microbiol. (kowsarpub.com)
- Nakayama, M 2011, ' MicroRNA signatures in Helicobacter pylori-infected gastric mucosa (共著) ', International journal of cancer . (elsevier.com)
- DeCothi GA, Newbold KM, O'Connor HJ (1989) Campylobacter-like organisms and heterotopic gastric mucosa in Meckel's diverticula. (springer.com)
- Lessells AM, Martin DF (1982) Heterotopic gastric mucosa in the duodenum. (springer.com)
- 1982) Heterotopic gastric mucosa in the duodenum - reaction to congo red under fiberscopic observation. (springer.com)
- The first known use of the H2-receptor antagonist cimetidine (Tagamet) in a case of a Meckel's diverticulum containing heterotopic gastric mucosa with ileal ulceration and hemorrhage is reported. (jamanetwork.com)
- Heterotopic gastric mucosa (HGM) is a rare anomaly in the small bowel and may be the cause of intussusception when it gets a lead point in the jejunum. (e-ce.org)
- Heterotopic gastric mucosa (HGM) is a rare anomaly in the small bowel and originates from the vitello-intestinal tract. (e-ce.org)
- We suggest that gastric pit dysplasia is an important candidate precursor of gastric adenocarcinoma and may represent another morphologic step in the pathogenesis of gastric adenocarcinoma, especially of intestinal type. (harvard.edu)
- AIM: To study the role of mitochondrial energy disorder in the pathogenesis of ethanol-induced gastric mucosa injury.METHODS: Wistar rats were used in this study. (journaldatabase.info)
- Vulnerability of Gastric Mucosa in Diabetic Rats, Its Pathogenesis and Amelioration by Cuminum cyminum. (newsnaturally.com)
- This study is the first attempt to understand the pathogenesis of gastric ulcers occurring during the diabetic state considering alternate biochemical pathways using suitable markers and its amelioration by Cuminum cyminum. (newsnaturally.com)
- Hazell SL, Carrick J, Lee A (1988) Campylobacter pylori can infect the esophagus when gastric tissue is present (abstract). (springer.com)
- We herein describe two cases of new histological subtypes: mixed fundic and pyloric mucosa-type adenocarcinoma detected in Helicobacter pylori uninfected patients. (ecancer.org)
- Histological examination of the resected specimens from both cases showed a very well- to well-differentiated adenocarcinoma which has differentiation towards the mixed fundic and pyloric mucosa. (ecancer.org)
- The present two cases demonstrate further evidence of a new histological subtype of gastric adenocarcinoma: mixed fundic and pyloric mucosa-type adenocarcinoma, which has distinct characteristic endoscopic findings. (ecancer.org)
- The aim of this study was to investigate the classic histological changes of the gastric mucosa in children with primary BRG. (springermedizin.de)
- The histological characteristics of the gastric mucosa were examined and scored. (springermedizin.de)
- This work aimed to determine the different endoscopic and histological changes in gastric mucosa promoted by smoking among H . pylori -positive and H . pylori -negative Egyptian patients with dyspepsia. (scirp.org)
- Selective norepinephrine accumulation in the mucosa of the esophagus and lesser gastric curvature is apparently due to its high permeability for norepinephrine contained in saliva. (springer.com)
- Adenocarcinoma of cervical esophagus arising in aberrant gastric mucosa. (bvsalud.org)
- We report an adenocarcinoma arising in ectopic gastric mucosa of the cardiac type in the cervical esophagus of a 60-year-old man. (bvsalud.org)
- Reflux esophagitis, the most common inflammatory condition involving the esophagus, is most often manifested on double-contrast studies by a finely nodular or granular appearance caused by edema and inflammation of the mucosa. (appliedradiology.com)
- Eradication of Helicobacter pylori may induce remission of low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma (1-3) . (annals.org)
- We followed 16 patients described in a previously published series (2) who had localized primary low-grade gastric MALT lymphoma and received anti- H. pylori therapy only. (annals.org)
- Isaacson and Wright 1 first reported a low-grade gastric lymphoma in 1983. (hkmj.org)
- Helicobacter pylori has been associated with the development of two malignant diseases: gastric adenocarcinoma and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. (asm.org)
- Although the cag pathogenicity island, especially the cagA gene, has been linked with adenocarcinoma, few data concerning H. pylori pathogenic factors involved in low-grade gastric MALT lymphoma are available. (asm.org)
- If the involvement of H. pylori in MALT lymphoma is well established, the pathomechanism by which gastric lymphoma occurs remains to be identified. (asm.org)
- In some individuals, immunological stimulation induces lymphoid follicles in the gastric mucosa and provides the background for MALT lymphoma development ( 11 ), the polyclonal lymphoid hyperplasia evolving further toward a monoclonal lymphoid population ( 36 ). (asm.org)
- Is Elevated Gastric Tissue NOX2 Associated with Lymphoma of Mucosa-Associated Lymphoid Tissue? (inserm.fr)
- We analyze for the first time NOX expression in a series of well characterized gastric MALT lymphoma (GML) patients in comparison with controls. (inserm.fr)
- Neonatal thymectomy in BALB/c mice has been described as a model of gastric mucosa-associated lymphoid tissue (MALT) lymphoma (GML). (inserm.fr)
Effect on the gastric mucosa2
Changes in the gastric mucosa2
- White light endoscopic images (upper) and magnified endoscopic images (lower) (a) Magnified endoscopic image before treatment showing disappearance of the normal gastric pit pattern and appearance of irregular abnormal vessels (arrows). (hkmj.org)
- However, considering the potential risk and costs of early detection by endoscopic examination, implementation reflecting an individual's risk for developing a gastric cancer would be ideal. (aacrjournals.org)
- Background, In our previous work, we developed a modified method for the removal of gastric submucosal tumors (SMTs), called endoscopic mucosa-sparing lateral dissection (EMSLD). (elsevier.com)
- Gastric hemorrhage and ulceration, hypotensive, hypovolemic shock, and severe electrolyte disturbances contribute to the high mortality. (thefreedictionary.com)
- Peptic ulceration resulting from ectopic gastric mucosa of the diverticulum Following perforation by trauma or ingested foreign material e.g. stalk of vegetable, seeds or fish/chicken bone that become lodged in Meckel's diverticulum. (wikipedia.org)
Development of gastric cancer4
- The knowledge about the precursor lesions in development of gastric cancer could contribute to cancer diagnosis at an early stage. (morebooks.de)
- These changes may have a role in the development of gastric cancer. (morebooks.de)
- However, the annual 1156 mucosa.22 This suggests that acquisition of stem cell prop- incidence of metachronous gastric cancer is up to 2.5%, 1157 erties in gastric epithelial Salvinorin A via CagA-mediated up-regu- indicating that gastric cancer develops even after bacterial 1158 development of gastric cancer. (bestatin.top)
- It is discussed whether this may have a causal relation to the development of gastric cancer. (ucr.ac.cr)
Ectopic gastric mucosa3
- This finding was consistent with a diagnosis of EDC, with ectopic gastric mucosa. (biomedcentral.com)
- However, few studies in the literature have addressed EDC with ectopic gastric mucosa. (biomedcentral.com)
- In this case study, we described a boy afflicted with intermittent fever of acute onset and dry cough, and diagnosed as having double EDCs containing ectopic gastric mucosa. (biomedcentral.com)
- Wagner-Meissner corpuscles are touch receptors that are located in dermal papillae and are usually absent in gastrointestinal mucosa. (biomedsearch.com)
- The Bilitec 2000 was used for 24 h monitoring of gastric bile in 59 children with upper gastrointestinal symptoms. (springermedizin.de)
- Phantom gastric mucosa for evaluating computed radiography in double-constrast upper gastrointestinal examinations. (semanticscholar.org)
- PURPOSE To test the clinical usefulness of computed radiography (CR) with a storage phosphor plate in upper gastrointestinal radiographic examinations, a newly devised phantom gastric mucosa was used. (semanticscholar.org)
- Acute or chronic gastrointestinal diseases cause irreparable damage to the gastric mucosa, which begin to appear other diseases. (medicalj-center.info)
- sin embargo, sus roles en la patogénesis de la enfermedad gastrointestinal superior no han sido claramente establecidos. (bvsalud.org)
- Helicobacter fue detectado a través de técnicas histopatológicas, análisis de PCR y FISH en biopsias del fundus gástrico de 20 perros con o sin signos de enfermedad gastrointestinal. (bvsalud.org)
- We have therefore studied the histo-morphological effects of pickled vegetables on the Rabbit gastric mucosa. (ac.ir)
- Gastric antral biopsies were taken from pediatric patients and volunteers to select H. pylori -positive and H. pylori -negative specimens. (aacrjournals.org)
- Conclusions: On the basis of an analysis of biopsies collected by esophagogastroduodenoscopy in the United States, gastric abnormalities increase with age. (elsevier.com)
- Patients and Methods: A cross-sectional study was conducted among 240 consecutive patients with dyspepsia who underwent upper endoscopy and histopathological examination of gastric biopsies at Zagazig and Tanta University Hospital with H. pylori-positivity assessment by stool antigen and rapid urease test. (scirp.org)
- Both patients and controls underwent extensive sampling of the gastric mucosa (two antral, one incisural, and two oxyntic biopsies). (elsevier.com)
- Gastric tissue was subjected to indirect double immunofluorescence staining with antiserum against the C-terminal decapeptide of the CCK2 receptor and antibodies against 5' bromo-2-deoxyuridine, which had been injected into the rats I h before they were killed, the acid pump H,K-ATPase, the membrane-cytoskeletal linker ezrin, pepsin/pepsinogen or histidine decarboxylase. (diva-portal.org)
- T. B. Timashkevich, The Mitotic Regime in the Gastric Mucosa of Rats, Candidate's Dissertation, Moscow (1967). (springer.com)
- In the present study the anti-ulcerogenic effect of tamrabhasma was observed in 8-h immobilised, 4-h pylorus-ligated, and aspirin-induced gastric ulcers in rats. (isharonline.org)
- The present study was conducted to evaluate the possible anti-ulcerogenic activity of fresh juice of C. asiatica (CAJ) against ethanol-, aspirin-, cold-restraint stress- and pyloric ligation induced gastric ulcers in rats. (isharonline.org)
- However, the inflammatory infiltrates of lymphocytes, plasma cells and polymorphonuclear leukocytes in the antrum and corpus mucosa were gradually increased from 2 weeks after the last inoculation of H. pylori. (nih.gov)
- At six weeks after the last inoculation, the gastric lesions were characterized by definite inflammatory infiltrates accompanied by the disruption of gastric architecture (Fig. 2, 3) and distinct H. pylori colonization (Fig. 4). (nih.gov)
- New phytopharmaceutical agent CJ-20001 modulates stress-induced inflammatory infiltration into gastric mucosa. (wizdom.ai)
- Effect of histamine H2 antagonism by metiamide on the response of the canine gastric mucosa to acid and bile salt. (harvard.edu)
- The bacteria secrete urease to neutralize the acidic condition of gastric mucosa, which then adheres to the cellular surface via blood-antigen binding protein A ( BabA ) and sialic acid-binding adhesion A ( SabA ) contributing to tissue damage by releasing several toxins such as cytotoxin-associated gene A ( CagA ) and vacuolating cytotoxin A ( VacA ) ( 4 ). (kowsarpub.com)
- Malondiadehyde (MDA) in gastric mucosa was measured with thiobarbituric acid. (journaldatabase.info)
- N = 11 for each group), and methylation of promoter CpG islands of 48 genes that can be methylated in gastric cancer cell lines was analyzed by methylation-specific PCR. (nih.gov)
- In addition, 14 genes were randomly or intermediately methylated in individuals with gastric cancers and the remaining 1 gene was methylated in all the cases. (nih.gov)
- Delayed in gastric retention due to dysfunction of the pylorus, abnormalities of gastric motility, foreign bodies and systemic diseases. (thefreedictionary.com)
- But there are some diseases in which to restore the gastric mucosa, it is mandatory. (medicalj-center.info)
- Whereas the bacterium is assessed to be embedded in the gastric mucosa of half the global population, only about 15 - 20 percent of colonised persons contributes to the development of such diseases . (scirp.org)
- We found that the major pathologic finding in gastric mucosa is hemorrhage of squamous shape. (curehunter.com)
- We have found that 21.0% (n=87) of gastric cancer cases showed pit dysplasia in adjacent gastric mucosa. (harvard.edu)
- Survival rates of gastric cancer (GC) have been low, due to the fact that its diagnosis is often late and made in the advanced stage. (morebooks.de)
- Among H. pylori -negative individuals, methylation levels of all the eight regions were 2.2- to 32-fold higher in gastric cancer cases than in age-matched healthy volunteers ( P ≤ 0.01). (aacrjournals.org)
- Among H. pylori -positive individuals, methylation levels were highly variable, and that of only HAND1 was significantly increased in gastric cancer cases (1.4-fold, P = 0.02). (aacrjournals.org)
- Methylation levels of specific CGIs seemed to reflect gastric cancer risk in H. pylori -negative individuals. (aacrjournals.org)
- Gastric cancer is one of the most common malignancies worldwide and remains a leading cause of cancer death in Asia and some European countries ( 1 ). (aacrjournals.org)
- Other risk factors for gastric cancers include high salt intake and smoking ( 9 ), and a cancer risk marker incorporating these factors is awaited. (aacrjournals.org)
- Gastric cancer tissues had a marked reduction of all three NOS isoforms expression. (nus.edu.sg)
- Background: Gastric cancer is the fourth most common malignancy in the world. (journaldatabase.info)
- Nutritional studies have indicated that consumption of honey modulates therisk of developing gastric cancer. (journaldatabase.info)
- We tested polynomial curve tofind the best fit between honey consumption and apoptosis.Results: A positive relation between honey consumption and apoptosis was found (P=0.024).Our results indicated that the final and the best fit curve was: apoptosis = 1.714+1.648(honeyamount) - 0.533(honey amount)2 +1.833×10-5(honey amount)7.Conclusion: Honey consumption had positive effects on gastric cancer by inducing apoptosis ingastric mucosa. (journaldatabase.info)
- Gastric cancer is one of the main causes of death worldwide. (kowsarpub.com)
- Gastric cancer is ranked as the fourth common cancer, and is also the second mortality cause worldwide ( 3 ). (kowsarpub.com)
- gastric cancer progression. (mi-rna.com)
- The gastric mucosa in gastric cancer patients in a low-incidence area. (unil.ch)
- Helicobacter pylori transactivates the Epidermal Growth Factor Receptor (EGFR) and predisposes to gastric cancer development in humans and animal models. (mdpi.com)
- This pathobiological pattern is considered to be associated with a low risk of distal gastric cancer. (elsevier.com)
- We performed comprehensive DNA methylation profiling of gastric mucosa after H. pylori eradication with or without gastric cancer. (fujita-hu.ac.jp)
- In the gastric body (cancer-free body + EGC body), methylation levels were significantly decreased in patients with longer period after eradication, while such association was not observed in EGC ADJ group. (fujita-hu.ac.jp)
- Gastric cancer (GC) is very common in Iran. (ac.ir)
- 3. As glycoproteins are the main constituent of the mucus defence barrier, epidermal growth factor-stimulated mucus production may contribute to gastric cytoprotection. (portlandpress.com)
- It significantly increased gastric mucus content, antioxidant status and cellular ATPase enzyme levels as compared to diabetic control animals. (newsnaturally.com)
- Furthermore, prolonged cigarette smoking really seemed to alter mucus production by the gastric mucosa . (scirp.org)
- In addition, for conditions such as peptic ulcers and gastric cancers, dyspepsia is frequently the first warning sign . (scirp.org)
- We have evaluated the surrounding gastric mucosa of 414 gastric cancers for the presence of gastric pit dysplasia. (harvard.edu)
- Gastric MALToma is uncommon and accounts for 1% to 5% of all gastric cancers. (hkmj.org)
- Risk prediction of gastric cancers is important to implement appropriate screening procedures. (aacrjournals.org)
- Gastric mucosae were collected from 154 healthy volunteers (56 H. pylori negative and 98 H. pylori positive) and 72 cases with differentiated-type gastric cancers (29 H. pylori negative and 43 H. pylori positive) by endoscopy. (aacrjournals.org)
- Effects of restrained water immersion stress on the metabolism of histamine in the gastric mucosa. (nii.ac.jp)
- Histamine content in the gastric mucosa increased 1.6 and 1.3 times, respectively. (nii.ac.jp)
- Anti-histamine N-methyltransferase (HMT) antibody detected a band in rat kidney, but not in gastric mucosa. (nii.ac.jp)
- Our previous studies demonstrated that ethanol injury triggers the angiogenic response in gastric mucosa bordering necrosis. (physiology.org)
- The present study was aimed to determine whether vascular endothelial growth factor (VEGF) (a potent angiogenic peptide selectively acting on endothelial cells) and Ras (a mediator of cell proliferation and a putative regulator of VEGF expression) are involved in gastric angiogenesis after ethanol injury. (physiology.org)
- We studied the angiogenic response and expression of VEGF and Ras in gastric mucosa after ethanol injury. (physiology.org)
- These studies demonstrated that angiogenesis, i.e., formation of new microvessels, occurs in the gastric mucosa acutely injured by ethanol. (physiology.org)
- We have previously demonstrated, in a preliminary study, that ethanol-induced injury triggers the angiogenic response in the gastric mucosa bordering necrosis and also activates expression of bFGF and its receptors in this area ( 36 ). (physiology.org)
- As the concentration of ethanol was elevated and the exposure time to ethanol was extended, the content of MDA in gastric mucosa increased and the extent of damage aggravated. (journaldatabase.info)
- We reviewed our previous morphological findings on over 300 scanning electron micrographs of 109 gastric bioptic specimens. (europeanreview.org)
- Studies have demonstrated that the major molecular targets recognised by parietal cell autoantibodies are the a- and b-subunits of the gastric proton pump (H/K-ATPase). (arodia.com)
- Five patients had multifocal disease, and anatomic gastric site changed in 3 patients. (annals.org)
- A study on gastric mucosa damage, antigen location, and virus dissociation in patients with epidemic hemorrhagic fever]. (curehunter.com)
- Methods, We prospectively enrolled 25 consecutive patients with gastric SMTs, who received EMSLD treatment. (elsevier.com)
- while Ferguson 3 found prolapse of the gastric mucosa in 23 (7.7%) of 297 consecutive patients. (jamanetwork.com)
- B) Levels of malondialdehyde and protein carbonylation in gastric tissues of Mongolian gerbils infected with H pylori KS strains or vehicle were measured. (bestatin.top)
- p53 overexpression and increased Ki-67 proliferation index were more evident in gastric pit dysplasia compared with adjacent gastric mucosa. (harvard.edu)
Nitric oxide sy1
- Nitric oxide synthase in gastric mucosa. (bmj.com)