Gastric analysis for determination of free acid or total acid.
Hydrochloric acid present in GASTRIC JUICE.
A lack of HYDROCHLORIC ACID in GASTRIC JUICE despite stimulation of gastric secretion.
Compounds that contain benzimidazole joined to a 2-methylpyridine via a sulfoxide linkage. Several of the compounds in this class are ANTI-ULCER AGENTS that act by inhibiting the POTASSIUM HYDROGEN ATPASE found in the PROTON PUMP of GASTRIC PARIETAL CELLS.
Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief.
A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The liquid secretion of the stomach mucosa consisting of hydrochloric acid (GASTRIC ACID); PEPSINOGENS; INTRINSIC FACTOR; GASTRIN; MUCUS; and the bicarbonate ion (BICARBONATES). (From Best & Taylor's Physiological Basis of Medical Practice, 12th ed, p651)
A 4-(3-methoxypropoxy)-3-methylpyridinyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
A family of gastrointestinal peptide hormones that excite the secretion of GASTRIC JUICE. They may also occur in the central nervous system where they are presumed to be neurotransmitters.
Organic compounds that have the general formula R-SO-R. They are obtained by oxidation of mercaptans (analogous to the ketones). (From Hackh's Chemical Dictionary, 4th ed)
Retrograde flow of gastric juice (GASTRIC ACID) and/or duodenal contents (BILE ACIDS; PANCREATIC JUICE) into the distal ESOPHAGUS, commonly due to incompetence of the LOWER ESOPHAGEAL SPHINCTER.
A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRIN output.
An organ of digestion situated in the left upper quadrant of the abdomen between the termination of the ESOPHAGUS and the beginning of the DUODENUM.
A 2,2,2-trifluoroethoxypyridyl derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS. Lansoprazole is a racemic mixture of (R)- and (S)-isomers.
Compounds with a BENZENE fused to IMIDAZOLES.
Drugs that selectively bind to but do not activate histamine H2 receptors, thereby blocking the actions of histamine. Their clinically most important action is the inhibition of acid secretion in the treatment of gastrointestinal ulcers. Smooth muscle may also be affected. Some drugs in this class have strong effects in the central nervous system, but these actions are not well understood.
A poly(dimethylsiloxane) which is a polymer of 200-350 units of dimethylsiloxane, along with added silica gel. It is used as an antiflatulent, surfactant, and ointment base.
Lining of the STOMACH, consisting of an inner EPITHELIUM, a middle LAMINA PROPRIA, and an outer MUSCULARIS MUCOSAE. The surface cells produce MUCUS that protects the stomach from attack by digestive acid and enzymes. When the epithelium invaginates into the LAMINA PROPRIA at various region of the stomach (CARDIA; GASTRIC FUNDUS; and PYLORUS), different tubular gastric glands are formed. These glands consist of cells that secrete mucus, enzymes, HYDROCHLORIC ACID, or hormones.
A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.
Substances that counteract or neutralize acidity of the GASTROINTESTINAL TRACT.
Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)
Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX.
The time frame after a meal or FOOD INTAKE.
A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).
The muscular membranous segment between the PHARYNX and the STOMACH in the UPPER GASTROINTESTINAL TRACT.
The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs and stimuli, hormone secretion, sleeping, and feeding.
Chemical compounds which yield hydrogen ions or protons when dissolved in water, whose hydrogen can be replaced by metals or basic radicals, or which react with bases to form salts and water (neutralization). An extension of the term includes substances dissolved in media other than water. (Grant & Hackh's Chemical Dictionary, 5th ed)
Elements of limited time intervals, contributing to particular results or situations.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12.
A synthetic pentapeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid.
An NADPH-dependent enzyme that catalyzes the conversion of L-ARGININE and OXYGEN to produce CITRULLINE and NITRIC OXIDE.
A quantitative prediction of the biological, ecotoxicological or pharmaceutical activity of a molecule. It is based upon structure and activity information gathered from a series of similar compounds.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
A hexamethyl-2,4,6-triamine derivative of 1,3,5-triazine.
The combining of administrative and organizational resources of two or more health care facilities.
Pressure, burning, or numbness in the chest.
Analysis of the HYDROGEN ION CONCENTRATION in the lumen of the ESOPHAGUS. It is used to record the pattern, frequency, and duration of GASTROESOPHAGEAL REFLUX.
Mobilization of the lower end of the esophagus and plication of the fundus of the stomach around it (fundic wrapping) in the treatment of GASTROESOPHAGEAL REFLUX that may be associated with various disorders, such as hiatal hernia. (From Dorland, 28th ed)
A group of pyrido-indole compounds. Included are any points of fusion of pyridine with the five-membered ring of indole and any derivatives of these compounds. These are similar to CARBAZOLES which are benzo-indoles.
A group of simple proteins that yield basic amino acids on hydrolysis and that occur combined with nucleic acid in the sperm of fish. Protamines contain very few kinds of amino acids. Protamine sulfate combines with heparin to form a stable inactive complex; it is used to neutralize the anticoagulant action of heparin in the treatment of heparin overdose. (From Merck Index, 11th ed; Martindale, The Extra Pharmacopoeia, 30th ed, p692)
A beverage made from ground COFFEA beans (SEEDS) infused in hot water. It generally contains CAFFEINE and THEOPHYLLINE unless it is decaffeinated.
The application of smoke, vapor, or gas for the purpose of disinfecting or destroying pests or microorganisms.
The double-layered skin fold that covers the GLANS PENIS, the head of the penis.
The salts or esters of salicylic acids, or salicylate esters of an organic acid. Some of these have analgesic, antipyretic, and anti-inflammatory activities by inhibiting prostaglandin synthesis.
The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.
A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.
A sympathomimetic that acts mainly by causing release of NOREPINEPHRINE but also has direct agonist activity at some adrenergic receptors. It is most commonly used as a nasal vasoconstrictor and an appetite depressant.
Analogs or derivatives of AMPHETAMINE. Many are sympathomimetics and central nervous system stimulators causing excitation, vasopressin, bronchodilation, and to varying degrees, anorexia, analepsis, nasal decongestion, and some smooth muscle relaxation.
Salts and esters of hippuric acid.
A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
A loosely defined group of drugs that tend to increase behavioral alertness, agitation, or excitation. They work by a variety of mechanisms, but usually not by direct excitation of neurons. The many drugs that have such actions as side effects to their main therapeutic use are not included here.

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole. (1/335)

BACKGROUND: Omeprazole has a greater intragastric pH elevating effect in Helicobacter pylori positive than negative subjects. Ammonia production by H pylori has been suggested as a probable mechanism. AIMS: To assess the effect of H pylori status on gastric acid secretion during omeprazole treatment, and to examine the possible role of ammonia neutralisation of intragastric acid in increased omeprazole efficacy in infected subjects. METHODS: Twenty H pylori positive and 12 H pylori negative healthy volunteers were examined before and six to eight weeks after commencing omeprazole 40 mg/day. On both occasions plasma gastrin and acid output were measured basally and in response to increasing doses of gastrin 17 (G-17). Gastric juice ammonium concentrations were also measured. RESULTS: Prior to omeprazole, measurements were similar in the H pylori positive and negative subjects. During omeprazole, median basal intragastric pH was higher in the H pylori positive (7.95) versus negative (3.75) subjects (p<0.002). During omeprazole basal, submaximal (180 pmol/kg/h G-17), and maximal acid outputs (800 pmol/kg/h G-17) were lower in H pylori positive subjects (0.0, 3.6, 6.0 mmol/h respectively) versus negative subjects (0.3, 14.2, 18.6 mmol/h) (p<0.03 for each). This effect was not explained by neutralisation by ammonia. CONCLUSION: The presence of H pylori infection leads to a more profound suppression of acid secretion during omeprazole treatment. The effect cannot be explained by neutralisation of intragastric acid by bacterial ammonia production and its precise mechanism has to be explained.  (+info)

Eradication of Helicobacter pylori increases gastric acidity in patients with atrophic gastritis of the corpus-evaluation of 24-h pH monitoring. (2/335)

BACKGROUND: Recent studies have shown that the eradication of Helicobacter pylori results in a gastric acid secretion which decreases to normal levels in patients with duodenal ulcer disease. The aim of this study was to evaluate the effect of eradication of H. pylori in a 24-h study of gastric acidity in patients with atrophic gastritis of the corpus. METHODS: Intragastric acidity was measured by continuous 24-h pH monitoring, and the histology of the gastric antrum and corpus were evaluated in 14 H. pylori-positive patients with histologically proven atrophic gastritis of the corpus (10 men, 4 women; mean age, 57 years) before and 1 year after anti-H. pylori therapy. RESULTS: H. pylori was absent in 13 of 14 patients 1 year after treatment. Both gastritis and atrophy scores were significantly lower after eradication therapy (P < 0.01). The 24-h median pH and the percentage of 24-h pH readings above 4.0 units were significantly decreased after eradication therapy (from 5.12 +/- 0.36 to 2.69 +/- 0.21, and from 65.5 +/- 6.6% to 28.2 +/- 6.1%, P < 0.01, respectively.) CONCLUSION: Eradication of H. pylori increases 24-h gastric acidity in patients with atrophic gastritis of the corpus. Improvement of the histology of the gastric antrum and corpus may lead to the normalization of gastric acidity.  (+info)

Proximal gastric vagotomy: effects of two operative techniques on clinical and gastric secretory results. (3/335)

PGV performed in 39 patients by separating the lesser omentum from the stomach beginning 6 or 7 cm proximal to the pylorus and skeletonizing the distal 1 to 2 cm of esophagus was followed by 15.4% of proven and 10.2 of suspected recurrent ulcers. Insulin tests were done during the first 3 months postoperatively on 31 of the patients, including the 6 with proven and the 4 with suspected recurrent ulcers. The peak acid output to insulin minus tha basal acid output (PAOI-BAO) was less than 5 mEq/hr in 16 cases (52%) and from 5 to 25 mEq/hr in the remaining 15 cases. In 6 patients with proven recurrent ulcer, PAOI-BAO averaged 21.9 mEq/hr (range, 11.3 to 41.8); in the 4 patients with suspected recurrence, 9.5 (range, 4.4 to 11.8). The operative technique was changed in one respect; the distal 5 to 7.5 cm of the esophagus was skeletonized. In 14 patients, the mean PAOI-BAO +/- S.E. within 3 months of PGV was 1985 +/- 0.7 mEq/hr, and 13 of 14 values were less than 5 mEq/hr. One patient developed recurrent ulcer and required re-operation; this patient's value for PAO-BAO was 1.8 mEq/hr. The results show quantitatively that great differences in the completeness of PGV result from differences in the periesophageal dissection and emphasize its importance if optimal results are to be obtained and, especially, if the efficacy of the operation is to be judged.  (+info)

Predictive value of perioperative gastric acid tests. (4/335)

Preoperative acid studies and early postoperative insulin tests in 275 patients undergoing various forms of vagotomy have been related to recurrent ulceration. Follow-up time has been from two to nine years, mean 4-3 years. Recurrence is directly related to basal acidity in both tests but is not related to stimulated acid levels preoperatively. In the insulin tests higher levels of acidity after insulin are associated with a higher incidence of recurrence. When positive, Hollander's and multiple criteria are both associated with a higher recurrence rate.  (+info)

Characteristics of time-dependent PCO2 tonometry in the normal human stomach. (5/335)

Factors that affect PCO2 measurement in balloon saline during gastrointestinal tonometry are unclear. They include carbon dioxide diffusion rate, correction factors for calculation of equilibrium PCO2 from measurements at saline dwell times that are shorter than needed for full equilibration, role of blood-gas analyser bias during ex vivo PCO2 measurements in saline, and normal values for intragastric PCO2 (PiCO2) and intramucosal pH (pHi) at equilibrium, and their differences from blood values. In a laboratory study, normal PCO2 changes in a saline-filled tonometer balloon placed in a saline bath at constant PCO2 were described by a non-linear model, with a half-time of mean 4.4 min and 95% equilibration at mean 83 min. In a study in 20 healthy volunteers, PiCO2 build up in a saline-filled tonometer balloon placed in the stomach, measured at dwell times of 10, 20, 30 and 60 min, was slightly (P < 0.05) slower than in vitro, with a half-time of mean 5.8 min and 95% equilibration at mean 110 min. Correction factors to derive equilibrium PiCO2 at short dwell times and independently from blood-gas analyser bias were calculated. The factors differed (P < 0.05) from those currently provided by the manufacturer. Normal threshold values (mean) were: equilibrium PiCO2 < or = 6.6 kPa, pHi > or = 7.33, PiCO2 to blood PCO2 difference < or = 1.1 kPa and pH difference > or = -0.06. PiCO2 did not differ from, and was directly related to, blood PCO2. These values provide a reference base for other studies and show that gastric mucosal PCO2 depends on alveolar ventilation if blood flow is adequate.  (+info)

Gastric tonometry: in vivo comparison of saline and air tonometry in patients with cardiogenic shock. (6/335)

Measurement of gastric intramucosal pH (pHi) has been advocated to assess gastric perfusion. Regional PCO2 (rPCO2) values are measured using saline tonometry (rsPCO2) and more recently using air tonometry (raPCO2). We compared 237 measurements of saline and air tonometry in 19 consecutive, severely ill patients (mean age 59 (range 31-76) yr, 19 males, APACHE II 22 +/- 7) with cardiogenic shock. Equilibration period was set to 90 min. Nineteen independent paired samples of mean raPCO2 and mean rsPCO2 of each patient showed good correlation (r = 0.93, P < 0.001). Mean raPCO2 was 6.5 (1.8) kPa and mean rsPCO2 6.8 (2.4) kPa. PCO2 measured by saline was significantly higher than that measured by air (P < 0.05). Bland and Altman analysis showed a bias (mean rsPCO2-mean raPCO2) of 0.3 kPa and a precision of 1.2 kPa. Agreement between the two methods decreased with increasing rPCO2 concentrations. Although air tonometry of rPCO2 is a promising technique, a systematic disagreement with saline tonometry at high rPCO2 values requires further investigation and cautious interpretation of these values.  (+info)

Toxic bile acids in gastro-oesophageal reflux disease: influence of gastric acidity. (7/335)

BACKGROUND: Bile acid toxicity has been shown in the gastric, colonic, and hepatic tissues; the effect on oesophageal mucosa is less well known. AIMS: To determine the spectrum of bile acids refluxing in patients with gastro-oesophageal reflux disease and its relation to oesophageal pH using a new technique of combined oesophageal aspiration and pH monitoring. METHODS: Ten asymptomatic subjects and 30 patients with symptoms of gastro-oesophageal reflux disease (minimal mucosal injury, erosive oesophagitis (grade 2 or 3 Savary-Miller), Barrett's oesophagus/stricture; n=10 in each group) underwent 15 hour continuous oesophageal aspiration with simultaneous pH monitoring. Bile acid assay of the oesophageal samples was performed using modified high performance liquid chromatography. RESULTS: The peak bile acid concentration and DeMeester acid scores were significantly higher in the patients with oesophagitis (median bile acid concentration 124 micromol/l; acid score 20.2) and Barrett's oesophagus/stricture (181 micromol/l; 43. 3) than patients with minimal injury (14 micromol/l; 12.5) or controls (0 micromol/l; 11.1). The predominant bile acids detected were cholic, taurocholic, and glycocholic acids but there was a significantly greater proportion of secondary bile acids, deoxycholic and taurodeoxycholic acids, in patients with erosive oesophagitis and Barrett's oesophagus/stricture. Although bile acid reflux episodes occurred at variable pH, a temporal relation existed between reflux of taurine conjugates and oesophageal acid exposure (r=0.58, p=0.009). CONCLUSION: Toxic secondary bile acid fractions have been detected in patients with extensive mucosal damage. Mixed reflux is more harmful than acid reflux alone with possible toxic synergism existing between the taurine conjugates and acid.  (+info)

Epidural analgesia with bupivacaine does not improve splanchnic tissue perfusion after aortic reconstruction surgery. (8/335)

Inadequate splanchnic tissue perfusion is relatively common during and after aortic surgery. We hypothesized that vasodilation caused by thoracic epidural analgesia improves splanchnic blood flow and tissue perfusion after aortic surgery. In this prospective, randomized, controlled study, we studied 20 patients undergoing elective aortic-femoral or aortic-iliac reconstruction surgery. Gastric and sigmoid colon mucosal PCO2 and pH were measured during surgery. An epidural bolus of bupivacaine 40 mg followed by infusion of 15 mg h-1 was started after operation in 10 patients. After operation, splanchnic blood flow and gastric and sigmoid colon mucosal PCO2 and pH were measured before and 2 h after the start of epidural analgesia. During surgery, the gastric mucosal-arterial PCO2 difference remained stable, whereas the sigmoid mucosal-arterial PCO2 difference increased during aortic clamping but returned to pre-clamping values after declamping. After operation, epidural analgesia had no effect on gastric or sigmoid mucosal-arterial PCO2 differences or on splanchnic blood flow.  (+info)

The major indication for oesophageal pH monitoring in our neonatal units is to determine whether silent reflux may be the underlying cause of a range of problems such as apnoea, bradycardia, or pneumonia or whether it may be aggravating neonatal chronic lung disease.. Detection of reflux by oesophageal pH monitoring using conventional criteria requires that the gastric content be acid-that is, pH below 4. The buffering effect of milk on gastric acidity is known but its extent and the influence on the interpretation of oesophageal pH records had not been determined in neonates.. The gastric pH records of all infants showed buffering of gastric acidity following milk feeds. The average time that the gastric pH was greater than 4 after feeds was a mean of 130 (SD 45) minutes, and by definition any reflux that occurred during these periods of buffering could not be detected. The gastric pH was less than 4 for a mean of 24.5% (SD 17.3%) of the total time. This is less than that reported for older ...
The purpose of this study was to characterize the lactic acid bacteria found in makgeolli in terms of bacterial identity and… Expand ...
A total of one thousand 300 new confirmed cases of Coronavirus have been reported in Delhi during the last twenty four hours taking the total number of cases to one lakh 45 thousand 427.
Or misfires. So I had a pretty eventful twenty four hours that came as a shock to many of my friends, and myself. And all while it was happening, I panicked for one reason and one reason only: I was alone. Ive been very content being alone for the past couple of weeks; having the…
BACKGROUND: Gastric bleeding in children is associated with critical illness, shock, and physical trauma. Histamine-2 receptor antagonist therapy is used prophylactically to treat gastric bleeding, but it is not known whether bolus dosing or continuous infusion dosing is more effective. OBJECTIVES: To compare the effects of continuous infusion intravenous ranitidine and intravenous bolus dosing of ranitidine on gastric pH in critically ill children and to look for correlation between illness severity scores and gastric pH. METHODS: Sixteen critically ill children were randomized into two groups. Children in group 1 received bolus dosing on day 1 and continuous infusion of ranitidine on day 2. Group 2 received the continuous infusion on day 1 and bolus dosing on day 2. Equivalent doses of ranitidine were based on weight. Continuous infusion regimen: ranitidine bolus of 0.15 mg/kg followed by continuous infusion at 0.15 mg/kg per hour for 12 hours. Bolus regimen: 1 mg/kg, two doses 6 hours apart. ...
Free gastric hydrochloric acid is essential for the production of peptic ulcer. It is possible by x-radiation to decrease or even abolish production of this acid, leading to subsequent healing of the ulcer. These observations serve as the rationale for the clinical use of x-ray therapy in the management of peptic ulcer.. Since Regaud et al.1 first studied the effect of x-ray on gastric secretion, numerous reports have indicated not only that irradiation will decrease gastric secretion, but also that, in general, the greater the exposure, the greater the decrease. In 1917 Bruegel2 reported the use of external x-ray radiation ...
An enzyme electrode based on a glass electrode for measuring penicillin-V concentration is described. In preparing this electrode, penicillinase is immobilized by cross-linking with a very fine film of glutaraldehyde, which is sprayed directly over the sensitive end of a pH glass electrode. The penicillin sensor was used for the determination of penicillin-V concentrations in phosphate buffer, fermentation broth and dairy milk, the ranges of concentrations detected being 1.5-15, 2.5-15 and 2-12 mM, respectively. The linearity, stability, sensitivity, reversibility and pH and buffer strength dependence of the electrode were examined and are discussed. An extremely short response time of less than 10 s is obtained with electrodes made in this manner.
This study investigated the pharmacokinetics and tolerability of single dose 50mg and 100mg mirabegron [Astellas Pharma] administered under fasted conditions
The hydrogen ion concentration is extremely important to the structural and functional integrity of living systems. Even slight changes in may cause profound changes in the large molecules and
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Hawkinss guitarwork is of course another essential component of the BIG sound. Like Wyskida, hes a player whos fully able to bring the pain in a relatively traditional manner-check out Earthmover, which features a lead riff thats heavily reminiscent of the Melvins doom-rock classic Night Goat-but whos just as concerned with the texture of the sound as with its weight. His best riffs, like the opening theme of Twenty Four Hour Dawn or the central pattern in Barrage, seem to be made of light as much as sound. They glint and burst, flash and dissolve. Occasionally, Hawkins takes a proper solo-theres a glorious, Sonny Sharrock-ian lead outburst around 1:45 into Twenty Four Hour Dawn-but hes a player more given to outbursts of texture. Theres a gorgeous ambient interlude in Twenty Four Hour Dawn (yes, I know Im citing this track frequently, but its long and eventful and amazing!), around the 5:00 mark, where the groove drops out, and Hawkins plays these alternately trilling and ...
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Effect of lafutidine (30 mg/kg) and cimetidine (10 mg/kg), relative to vehicle, on (A) intragastric acidity and (B) weight of gastric content measured 60 and 12
The 12 Best Home Remedies For Acidity That Will Surprise You WHAT IS ACIDITY? Acidity occurs by excess secretion of acid in the gastric glands of the stomach. It secretes Hydrochloric acid required ...
What are the causes of hyper acidity?? And how can same be treated?? Does hyper acidity lead to stomach cancer?? Is Ocid-20 an effective medicine for Hyper Acidity, if yes what are the recommended dose...
A person becomes the patient of constipation due to acidity and because of this reason he suffers from light ache in the stomach. In this disease, food taken by the patient does not digest properly.
I am a 39 years old male |b|suffering from acidity|/b|, which is accompanied by severe headache, neck pain and vomiting sensation. Zintac gives me temporary relief. Is it safe to take this medicine for acidity? Does acidity cause neck pain?
What does acidity mean? acidity is defined by the lexicographers at Oxford Dictionaries as The level of acid in substances such as water, soil, or wine., Bitterness or sharpness in a persons remarks or tone.
Learn All About Acidity, Symptom, Treatment, Doctors, Diagnosis, Home Remedies, Question & Answer. Find Out How to Cure Acidity Only at Lybrate
Acidity is a common health problems nowadays, mainly because of unhealthy food, bad digestion, excessive intake of caffeine, tobacco or alcohol. Know how Yoga can help you get rid of acidity.
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Article pH Theory & Measurement. WHAT IS pH?pH is a short form for the Power (p) of Hydrogen (H). pH is defined as the negative log of the hydrogen ion activity, aH~ or the effective hydrogen ion concentration.Descriptive DefinitionpH is a unit of me...
1) A scale for measuring hydrogen ion concentration in a solution is called pH scale. 2) pH value of a solution is simply a number which indicates the acidic or basic nature of a solution. 3) If pH value = 7, it is a neu…
The pH of healthy blood is 7.35-7.45. This means that it is slightly alkaline. This alkalinity has to be kept almost constant; even minor variations are dangerous. If the hydrogen ion concentration in the blood rises to pH 6.95, coma and death result as the heart relaxes and ceases to beat.. The major affect from an overly acidic body chemistry is depression of the central nervous system. In extreme cases when the pH of the blood falls below 7.0, the nervous system becomes so depressed that the person first becomes disoriented and finally comatose.. In less severe cases, this translates into inhibited brain and nerve action. One who has an alkaline blood condition can think and act (decide) well. On the other hand, one who has an acidic blood condition cannot think well or act quickly, clearly or decisively. Therefore it is very important to maintain an alkaline blood condition all the time - not only for physical health, but also for mental awareness.. On a physical level, as our blood becomes ...
Thursday, June 18, 1998 ay. June 18,1996 Premium list rules Page 4 QCNCRAL MEOUimEMCMT 1. All exhibit* must be removed from the Fair grounds within twenty four hours after exhibit* are officially released by the Pair Association. 2. The Iron Co. Edition of Ironwood Daily Globe
Since heart problems run in my family, the decision was made to keep me overnight and do blood enzyme tests every eight hours to see if I had actually had a heart attack. To make a long story short, despite the fact that I was allowed to have my laptop at the hospital with me-- and I even had a pillow from home-- I was so BORED and uncomfortable that I was miserable there. It was one of the longest twenty four hour stretches of my life! Luckily everything came back normal and so I was sent home the next day (Saturday) and told to come in for a stress test early in the week ...
The best way to avoid acidity is to reduce oil and spicy items which is normal in our country, also, Timing is very important for having foods, example, Breakfast should be taken around 8am, lunch should be taken around 12:30pm to 1:00pm and dinner should be taken around 7:30pm to 8:00pm ...
Online Doctor Chat - Remedies for acidity, Ask a Doctor about diagnosis, treatment and medication for Belching, Online doctor patient chat conversation by Dr. Jyoti Patil
From the UOW, nice to see that man isnt the culprit in this case. UOW data confirm surprising atmospheric findings By Melissa Coade - Satellites showing that nature is responsible for 90% of the earths atmospheric acidity shocked researchers from the Belgian Institute for Space Aeronomy, whose findings have just been published in the journal…
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The hydrogen ion concentration in the lesions of experimental pneumococcus infection has been estimated directly by pH determinations on exudates from living animals. For indirect evidence of an increase in hydrogen ion concentration within the lesions, the difference in sugar content between exudate and blood from animals with pneumococcus infection has been measured.. With sanguinous exudate from the consolidated lungs of dogs with experimental pneumococcus pneumonia, the findings were not always consistent, but usually there was either direct or indirect evidence of increased hydrogen ion concentration. The physicochemical changes in exudate from animals treated with artificial pneumothorax showed no important differences from those in other specimens. In concurrence with Lords (1, 2) observation of increased acidity in pneumonia exudate obtained at autopsy, sugar concentrations, which are low in the blood, were markedly reduced in exudates from animals which had died of the ...
YF476 is clearly a potent and selective gastrin/CCK-B antagonist and should inhibit basal and meal-stimulated gastric acid secretion and enhance gastric emptying of a liquid meal in man. Therefore YF476 might benefit patients with reflux oesophagitis. The compound has been well tolerated in animal toxicity studies at doses in excess of the projected therapeutic dose in patients, and merits studies in healthy volunteers. Extrapolation from data obtained in animals suggests that a single oral dose of about 10mg of YF476 should compare favourably with an oral dose of 150mg of ranitidine in man with respect to effect on basal and food-stimulated gastric acid secretion. Therefore in the proposed study a range of doses of YF476 encompassing that dose will be studied; the exact dose of YF476 will be chosen on the basis of the previous study but the top dose will not exceed 100mg. 24-hour ambulatory gastric pH will be monitored via an intragastric pH electrode (7-10). Although there is variability ...
This is 100th anniversary of the glass pH electrode yet we still do not know much about what affects their life. Not much has been published about application problems and practices. There have been a few academic studies on the effect of process conditions on the glass electrode but these are over 20 years old. The best book on the theory of pH measurement The Determination of pH is over 35 years old. The glass electrode is more important than ever because of its extraordinary rangeability and sensitivity to hydrogen ion concentration. What other measurement can cover 14 orders of magnitude of concentration and detect changes as small as 0.00000000000001 (0 to 14 pH scale).. While the fundamentals of the glass pH electrode have not changed in a hundred years, there have been significant improvements in the glass formulation and construction so that it can handle high pH and high temperature fluids and repeated sterilizations. For example a new high temperature electrode increases the life ...
In the early twentieth century various investigators believed that patients with reduced gastric acid secretion were especially susceptible to bacterial enteric infections. Since many bacteria are promptly killed in an acidic environment, gastric acidity was thought to act as a barrier to ingested microorganisms. Despite a century of study, the concept of a gastric barrier to ingested microorganisms is still insufficiently understood. In this paper we update the older observations and discuss the interaction between bacteria and gastric acid, and other variables that may influence the survival of ingested bacteria in the stomach. In addition to recent data dealing with nontyphoidal salmonellosis, cholera, and shigellosis, we present information pertinent to other bacterial and parasitic enteric diseases. We believe that the available data, although incomplete, support the concept that gastric hypochlorhydria or achlorhydria increases both susceptibility to and severity of bacterial and ...
Robert Hodgkinson, Raymond Glassenberg, Thomas H. Joyce, Dennis W. Coombs, Gerard W. Ostheimer, Charles P. Gibbs; Comparison of Cimetidine (Tagamet®) with Antacid for Safety and Effectiveness in Reducing Gastric Acidity before Elective Cesarean Section. Anesthesiology 1983;59(2):86-90. doi: Download citation file:. ...
A robust pH sensor from Endress+Hauser can now solve the problem of reference contamination commonly experienced during pH measurement in ultra harsh conditions such as mining slurries and paper & pulp applications.. pH measurement within ultra harsh applications that include high solid content poses several challenges. Because of the harmful ions that defuse into the pH electrode reference system and the high solid content, the potential to disable the electrode by blocking the diaphragm under these extreme conditions is high. The surface area of the pH electrode diaphragm therefore needs to be enlarged to avoid blockage. However this increases the risk of reference contamination as the diaphragm is porous and more harmful ions can now enter the reference system of the pH electrode.. Traditionally, these enlarged diaphragms have been made from wood due to its resistance to contamination, but the wooden diaphragm is relatively thick and slows down the electrodes response time. In most critical ...
By Chaudhry, A S Kochhar, R; Kohli, K K Proton pump inhibitors (PPIs) are extensively metabolized in the liver by CYP2C19, that demonstrates genetic polymorphism with 21 mutant alleles. The subjects can be divided into 2 groups with respect to CYP2C19 phenotypes viz., extensive metabolizers (EMs) and poor metabolizers (PMs) of PPIs. This division results in marked interindividual variations in the pharmacokinetics and pharmacodynamics of PPIs in the population. Intragastric pH values and the plasma concentration of PPIs after oral ingestion were significantly lower in EMs namely normal homozygotes (CYP2C19*1/*1) and heterozygotes (CYP2C19*1/*X) compared to PMs namely mutant homozygotes (CYP2C19*X/*X) where X represents the mutant allele. Hence, association has been found between the genetic polymorphism of CYP2C19 and therapeutic response to PPIs. CYP2C19 polymorphism affected eradication of Helicobacter pylori using diferent PPI based eradication therapies as PM patients demonstrated ...
Defective absorption of calcium has been thought to exist in patients with achlorhydria. Hunt et al found gastric secretion of acid is required for the absorption of calcium from carbonate; however, absorption of calcium from calcium monocitrate was consistent irrespective of pH.20 Recker et al also found decreased absorption of calcium from the carbonate form in patients with achlorhydria. They found absorption of calcium as a pH-adjusted citrate salt was superior to carbonate in individuals with normal gastric acidity, and absorption of the citrate salt was not negatively affected by decreased gastric acidity. In fact, their findings indicate absorption of calcium as a citrate salt was significantly higher in individuals with achlorhydria than in subjects with normal gastric acidity.27 In contrast to these studies suggesting the requirement of HCl for absorption of calcium from carbonate, Bo-Linn et al concluded stomach acid production was not important in absorption of calcium from carbonate ...
Page contains details about rhodamine B-sensitized ZnO/ITO glass electrode . It has composition images, properties, Characterization methods, synthesis, applications and reference articles :
When some strong acid is added to an equilibrium mixture of the weak acid and its conjugate base, the equilibrium is shifted to the left, in accordance with Le Châteliers principle. Because of this, the hydrogen ion concentration increases by less than the amount expected for the quantity of strong acid added. Similarly, if strong alkali is added to the mixture the hydrogen ion concentration decreases by less than the amount expected for the quantity of alkali added. The effect is illustrated by the simulated titration of a weak acid with pKa = 4.7. The relative concentration of undissociated acid is shown in blue and of its conjugate base in red. The pH changes relatively slowly in the buffer region, pH = pKa ± 1, centered at pH = 4.7 where [HA] = [A−]. The hydrogen ion concentration decreases by less than the amount expected because most of the added hydroxide ion is consumed in the reaction ...
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1. An accurate quantitative method of measuring the penetration of dye into the living cell is described. 2. Cresyl blue is unable to penetrate rapidly unless the pH outside the cell is decidedly greater than that inside. The rate of penetration increases with increasing pH. 3. Around pH 9 penetration of the dye is rapid while the reverse is true of exosmosis. At low pH values (5.9) exosmosis is rapid and penetration is very slow. ...
1. In the growth and death of the pneumococcus in fluid media containing 1 per cent glucose the production of acid is the most important bactericidal factor. 2.
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Analysis of ambulatory 24-hour intragastric pH monitoring. Comparison of the effects of cimetidine 200mg QID and 800mg UID.:Comparison of the effects of cimetidine 200mg QID and 800mg UID (1988 ...
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details ...
Doctors Ask: Acidity directly affects digestion and assimilation of food. Sometimes too much gastric juice is produced, which leads to increased acidity, writes News Track India. Also, increasing the acidity contributes to the consumption of certain products. Such products are not capable of giving for a long time the feeling of satiety.
The link between cancer metabolism and immunosuppression, inflammation and immune escape has generated major interest in investigating the effects of low pH on tumor immunity. Indeed, microenvironmental acidity may differentially impact on diverse components of tumor immune surveillance, eventually contributing to immune escape and cancer progression. Although the molecular pathways underlying acidity-related immune dysfunctions are just emerging, initial evidence indicates that antitumor effectors such as T and NK cells tend to lose their function and undergo a state of mostly reversible anergy followed by apoptosis, when exposed to low pH environment. At opposite, immunosuppressive components such as myeloid cells and regulatory T cells are engaged by tumor acidity to sustain tumor growth while blocking antitumor immune responses. Local acidity could also profoundly influence bioactivity and distribution of antibodies, thus potentially interfering with the clinical efficacy of therapeutic antibodies
Most pregnant women suffer from about acidity and heartburn during pregnancy. Find 10 ways to prevent and deal with acidity and heartburn during pregnancy here.
How is Intragastric Alcohol Infusion Rat Model abbreviated? IAIRM stands for Intragastric Alcohol Infusion Rat Model. IAIRM is defined as Intragastric Alcohol Infusion Rat Model very rarely.
Hello - I was planning to answer this question for you, but am called away for other tasks. If I have a chance, I will finish the answer, otherwise, another researcher may be able to furnish you with a complete answer. pKa is a property of a compound which can undergoe acid-base chemistry and is a reflection of the compounds propensity to give up or accept a hydrogen ion. It is related, quite intimately, to the more common term of pH. Simply put, the pKa of compound X is related to the pH of a solution of compound X when it is at equilibrium between its acid and base forms. In more depth, the pH is the negative logarithm of the hydrogen ion concentration in a solution (a reflection of the acidity of the solution - the more hydrogen ions, the more acidic the solution, and the lower the pH). The pKa is the negative logarithm of the equilibrium constant (Ka) of the acid-base reaction of the compound of interest. The pKa of a compound relates to how likely, at a give pH, the compound will be ...
People with acidity show symptoms like esophagus pain (just below the neck) and stomach irritation and sour belching after eating food. Sometimes, people with acidity also have constipation and indigestion problems.
One of the most common and overlooked limitations in crop production is soil acidity. With the cultivation of the land and the harvest of high yielding crops, soil acidity has gradually increased and is becoming a problem throughout the region.
Organic photoacids with enhanced acidities in the excited states have received much attention both experimentally and theoretically because of their applications in nanotechnology and chemistry. In this study, we investigate excited-state acidities of 14 hydroxyl-substituted aromatic photoacids, with a focus
Acidity is a common problem that everyone has faced in life. There are many home remedies for acidity that have been used by people that really works.
How to do correct and accurate pH measurement? The right equipment selection, handling and maintenance are explained in this pH Theory Guide.
Symptoms. You will know if you are suffering from food poisoning because the symptoms will manifest as early as one hour to twenty four hours after the consumption or ingestion of the foods contaminated by a virus or bacteria. The symptoms of food poisoning include continuous vomiting, abdominal pains, diarrhoea and fever.. When to see the doctor. It is crucial that you seek for the opinion of experts once you have identified the symptoms. If your diarrhoea continues for more than 1 week despite the hydration agents and other medications, you should see the doctor. If your stool has some blood, you should also tell your doctors. If you have kids with the symptoms of food poisoning, you have to refer it to your doctor so they can give your kid intravenous fluids to replace the liquids lost in the body.. Treatment. The good thing about food poisoning is that you can treat yourself or you can consider self-medication. The secret is to replace the fluids that you have lost. You need to stay ...
After the brain surgery... The neurological observations were taken every hour for the twenty four hours following my cranial biopsy surgery. I tried my hardest to keep focused and to pass. After all, it was my first mid-semester exam (a little joke as its that time at university and I was having a pretty serious…
Individuals with CF have actually many different signs including: extremely salty-tasting epidermis; persistent coughing, on occasion with phlegm; wheezing or shortness of breathing; an extortionate appetite but bad weight gain; and oily, cumbersome stools. Signs differ from individual to individual, in component, as a result of above 1,000 mutations regarding the CF gene, a number of that have been identified and sequenced by researchers. The perspiration test could be the standard test that is diagnostic CF. This easy and painless procedure steps the actual quantity of sodium within the perspiration. A top sodium degree shows CF. Even though the outcomes of this test are legitimate any moment after an infant is twenty four hours old, gathering a big sweat that is enough from a child more youthful than a few days old could be difficult. The perspiration test can confirm the diagnosis also in older kids and adults. If pancreatic enzyme levels are paid off, an analysis of the individuals stool ... We know many fruits are highly acidic. But are they bad? Dr. Robert O. Young says that they may be. However there are other fruits that are more alkaline and could be healthier. Find out what Dr. Young things about what some fruits may do to the acidity in the gut and what that could lead to.
Question - Having acidity, constipation and severe concentration problem. Suggest the treatment? . Ask a Doctor about when and why Magnetic resonance imaging is advised, Ask a Neurologist
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1. The acidity of the cancer fluid of rat sarcoma 10 generally increases with the age of the tumor.. 2. It is not possible to correlate increase in acidity with rate of growth of tumor.. 3. The tumor fluid is under a higher CO2 tension than the blood.. ...
రంగారెడ్డి: మైలార్‌దేవ్‌పల్లిలో కింగ్స్‌ కాలనీలో ముస్తఫా అనే వ్యక్తిపై దుండగుల కాల్పులు,కడప: జగన్ సీఎం అయితే తన ఆస్తులు పెరుగుతాయి..చంద్రబాబు సీఎంగా ఉంటే ప్రజల ఆస్తులు పెరుగుతాయి: మంత్రి సోమిరెడ్డి,సిరిసిల్ల: అన్ని గ్రామాల్లో కేసీఆర్ గ్రామీణ ప్రగతి ప్రాంగణాలు నిర్మిస్తాం: మంత్రి కేటీఆర్,హైదరాబాద్: బంజారాహిల్స్ పోలీస్‌ స్టేషన్‌లో యూసుఫ్‌గూడ కార్పొరేటర్ తమ్ముడిపై కేసు ...
A very common situation in orchards and gardens is the disparity in the development of some species, which have very different production and development
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A 100 liter barrel of vinegar is 8% acetic acid. Before it can be bottled and used in cooking, the acidity must be reduced to 5% by diluting it with
Water for Health - Alkaline Water Products, Green Superfood Drink Powders and innovative products to reduce acidity and improve body pH balance
"Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Aliment. Pharmacol. Ther. ... 2006). "Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in ... The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis comparing the net benefit ... With gastric malignancies, relief of symptoms due to the use of ranitidine does not exclude the presence of a gastric ...
... gastric acidity determination MeSH E01.450.150.470 - limulus test MeSH E01.450.150.810 - urinalysis MeSH E01.450.230.050 - ... gastric acidity determination MeSH E01.370.372.310 - gastrointestinal transit MeSH E01.370.372.450 - lactose tolerance test ... blood volume determination MeSH E01.370.370.170 - capillary fragility MeSH E01.370.370.380 - heart function tests MeSH E01.370. ... blood pressure determination MeSH E01.370.600.115 - body constitution MeSH E01.370.600.115.100 - body weights and measures MeSH ...
Nakada, Yuichiro; Yokomachi, Hideharu; Iwakura, Yasushi; Takahashi, Yoshiteru; Ozawa, Naoki (1999). "Effect of gastric acidity ... Ren, Y; Liu, T; Song, G; Hu, Y; Liang, J (February 2014). "Determination of lomerizine in human plasma by liquid chromatography ... The bioavailability of orally administered lomerizine is unaffected by gastric pH. Selt M, Bartlett CA, Harvey AR, Dunlop SA, ...
It is also expected to disrupt sex ratios in many reptiles which have temperature-dependent sex determination. The removal of ... Rising levels of carbon dioxide are resulting in influx of this gas into the ocean, increasing its acidity. Marine organisms ... the extinction of the golden toad in Costa Rica and the Gastric-brooding frog in Australia. Many other amphibian species now ...
Used as an acidity regulator, anticaking agent, stabilizer or color it is approved for usage in the EU, USA and Australia and ... Calcium carbonate is widely used medicinally as an inexpensive dietary calcium supplement for gastric antacid (such as Tums). ... 0090". National Institute for Occupational Safety and Health (NIOSH). Strumińska-Parulska, DI (2015). "Determination of 210Po ...
i.e. during the gastric phase) Inhibitory factor: acidity (pH below 3) - a negative feedback mechanism, exerted via the release ... Higashimoto Y, Himeno S, Shinomura Y, Nagao K, Tamura T, Tarui S (May 1989). "Purification and structural determination of ... Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in ... The presence of gastrin stimulates parietal cells of the stomach to secrete hydrochloric acid (HCl)/gastric acid. This is done ...
Chen YQ, Kraut J, Blakley RL, Callender R (June 1994). "Determination by Raman spectroscopy of the pKa of N5 of dihydrofolate ... A regimen of fluorouracil, doxorubicin, and methotrexate was shown to prolong survival in patients with advanced gastric cancer ... The acidity of the targeted nitrogen on the substrate is important in the binding of the substrate to the enzyme's binding site ... 1s3u: Structure Determination of Tetrahydroquinazoline Antifolates in Complex with Human and Pneumocystis carinii Dihydrofolate ...
Testing the acidity of saliva occurred at least as early as 1808. The testing of salivation by the use of mercury was performed ... Gubała W, Zuba D (2002). "Saliva as an alternative specimen for alcohol determination in the human body". Pol J Pharmacol. 54 ( ... pylori detected via gastric biopsy. Based on their results, researchers concluded that saliva testing could serve as a reliable ... In 1999 researchers determined that ELISA-based saliva testing "can serve as a reliable [method] for estriol determination." A ...
Gastric acid, hydrochloric acid secreted into the stomach to aid digestion of proteins Chloride, salts of hydrogen chloride ... Trummal, A.; Lipping, L.; Kaljurand, I.; Koppel, I. A.; Leito, I. "Acidity of Strong Acids in Water and Dimethyl Sulfoxide" J. ... Analysis of spectroscopic and dielectric data, and determination of the structure of DCl (deuterium chloride) indicates that ...
6. Observation of gastric and duodenal motility using synthetic motilin]". Nihon Heikatsukin Gakkai Zasshi. 11 (4): 244-6. PMC ... Guillén-Casla V, Rosales-Conrado N, León-González ME, Pérez-Arribas LV, Polo-Díez LM (April 2012). "Determination of serotonin ... Acidity (pKa) 10.16 in water at 23.5 °C[2]. Dipole moment ... mammalian tissues and urine and a method for its determination" ...
Rising levels of carbon dioxide are resulting in influx of this gas into the ocean, increasing its acidity. Marine organisms ... It is also expected to disrupt sex ratios in many reptiles which have temperature-dependent sex determination. ... the extinction of the golden toad in Costa Rica and the Gastric-brooding frog in Australia. Many other amphibian species now ...
"Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Aliment. Pharmacol. Ther. ... 2006). "Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in ... The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis comparing the net benefit ... With gastric malignancies, relief of symptoms due to the use of ranitidine does not exclude the presence of a gastric ...
Value and indications of gastric acidity determination]. Download Prime PubMed App to iPhone, iPad, or Android ... Blood GlucoseGastric Acidity DeterminationGastric JuiceGastric MucosaGastrinsGastritisHistamineHumansInsulinMethodsPepsin A ... Schmidt, H A.. "[Value and Indications of Gastric Acidity Determination]." Der Internist, vol. 10, no. 7, 1969, pp. 258-64. ... TY - JOUR T1 - [Value and indications of gastric acidity determination]. A1 - Schmidt,H A, PY - 1969/7/1/pubmed PY - 1969/7/1/ ...
... the onset of action of ranitidine and famotidine on gastric pH can be determined for individual subjects as well as for the ... Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity Aliment Pharmacol Ther. 2002 ... When onset was defined in terms of a particular decrease in gastric acid concentration for the group as a whole or for ... Results: When the onset of action was defined as the earliest time that mean gastric pH with active treatment was statistically ...
Seventy to 80% of gastric carcinoids are type I, which usually are clinically asymptomatic and found incidentally at endoscopic ... Gastric carcinoid tumors comprise 7% of all gastrointestinal carcinoids and have significantly increased in incidence over the ... Gastric Acidity Determination * Gastric Fundus / pathology * Gastric Fundus / physiopathology * Gastric Fundus / surgery ... Review of the pathogenesis, diagnosis, and management of type I gastric carcinoid tumor World J Surg. 2011 Aug;35(8):1879-86. ...
Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. The present study was ... has previously been detected in the glandular part of the human gastric mucosa. ... Gastric Acid / secretion*. Gastric Acidity Determination. Gastric Mucosa / drug effects, enzymology, metabolism*. Histamine / ... Immunofluorescence of an isolated gastric gland. Immunolocalization of eNOS (arrowheads) in a gastric gland isolated from human ...
... but the possibility cannot be excluded that its better pharmacodynamic effect on gastric acidity also has a positive result in ... Gastric Acid / secretion. Gastric Acidity Determination. Gastrins / blood. Humans. Male. Middle Aged. Omeprazole / ... CONCLUSIONS: The two omeprazole regimens we tested are effective in reducing gastric acidity, and their pharmacodynamic action ... but the possibility cannot be excluded that its better pharmacodynamic effect on gastric acidity also has a positive result in ...
Gastric Volume, Titratable Acidity, and Acid Output Determination. The collected gastric juice was centrifuged at 1000 g for 10 ... Gastric mucus acts as a protective barrier from the noxious effects of both gastric acidity and pepsin [26] and possesses free ... on gastric volume (a), titratable acidity (b), and acid output (c) in indomethacin-induced (INDO; 20 mg/kg, i.p.) gastric ... Mucin Content Determination. The mucin content of the gastric juice was determined according to the method described by Winzler ...
2.7.3. Determination of Free Acidity and Total Acidity [17, 18]. 1 mL of gastric juice was pipette out into a 100 mL conical ... 2.7.2. Determination of pH of Gastric Content [16]. 1 mL of the gastric juice was collected, and pH was directly measured by ... 2.7.1. Determination of Gastric Volume [15]. After sacrificing the rat, the stomach portion was removed. The gastric contents ... E. J. Beckers, N. J. Rehrer, F. Brouns, F. Ten Hoor, and W. H. M. Saris, "Determination of total gastric volume, gastric ...
"Determination of the time of onset of action of ranitidine and famotidine on intra-gastric acidity". Aliment. Pharmacol. Ther. ... 2006). "Therapy With Gastric Acidity Inhibitors Increases the Risk of Acute Gastroenteritis and Community-Acquired Pneumonia in ... The drug increases gastric pH, but generally has no effect on gastric volume. In a 2009 meta-analysis comparing the net benefit ... With gastric malignancies, relief of symptoms due to the use of ranitidine does not exclude the presence of a gastric ...
Gastric Acidity Determination. *Gastroesophageal Reflux (drug therapy, physiopathology) *Humans. *Hydrogen-Ion Concentration ...
... gastric acidity may contribute to confusion. Implicated xenobiotics include chloroform, carbon tetrachloride, chloroform, ... Potential causes of acute copper salt poisoning should be addressed include informed consent; determination that the oral ...
... on experimentally induced gastric ulceration in Wistar rats, SS Sakat, Preeti Tupe, Archana Juvekar ... Determination of total acidity. An aliquot of 1 ml gastric juice diluted with 1 ml of distilled water was taken into a 50 ml ... Table 2: effect of meoc on gastric content, ph, total acidity and free acidity in pylorus ligation induced gastric ulceration ... significantly decreased gastric secretions, total acidity, free acidity and increased pH of the gastric juice compared to ...
is metformin 500 mg a high dose Food and/or rNA, especially by reducing resting 3 267 They stimulate gastric irritants. It is ... 1 44 3857 are now have been almost complete On discharge, and other magnesium determinations. The only a use of salmeterol are ... Psoralen is prolonged with- drawn between myocardial infarction, iX are both acidity. Reproduced what is the chemical name for ... Three months, as a fall in non-pregnant women is charac- terized by convulsions or gastric contents. Dapsone how to reverse ...
A highly selective and sensitive, spectrophotometric method is developed for the determination of Mercury(II) in environmental ... Article Determination of trace amounts of mercury (II) by catalytic kinetic method in environmental samples. ... The mechanisms for nitrite bioactivation are unclear, but recent studies in rodents suggest that gastric acidity may influence ... Determination of trace amounts of mercury (II) by catalytic .... Determination of trace amounts of mercury (II) by catalytic ...
... evaluation of gastric content parameters such as volume, pH, free and total acidity, protein estimation, and quantification of ... In pylorus-ligation model, EAF significantly (p <0.001) prevent gastric lesion formation. Volume of gastric content and total ... protein content reduced significantly (p < 0.01 and p < 0.05, respectively), while free and total acidity reduced in the doses ... The mechanism of gastroptotection of EAF was further investigated using pylorus ligation-induced gastric lesion rat model (100 ...
Determination of gastric acidity without intubation by use of cation exchange indicator compounds. Proc Soc Exper Biol Med 1950 ... Differentiation between benign gastric ulcer and gastric carcinoma (20% of gastric carcinomas are accompanied by gastric ... The amount of dye excreted is proportional to the total gastric acidity. Since tubeless gastric analysis requires the ... Still others attributed gastric acidity primarily to the presence of acid phosphates in the juice. There was general reluctance ...
... along the greater curvature and the gastric juice was collected into a small beaker for volume and acidity determinations (3). ... Effect of scorpion toxin on gastric emptying Data concerning gastric emptying are presented in Figure 1. The fraction of the ... Gastric emptying. Gastric emptying was assessed by determining the fractional radioactivity present in the stomach after ... Schurizek BA (1991). The effects of general anaesthesia on antroduodenal motility, gastric pH and gastric emptying in man. ...
Except for pH and total acidity, MMMC also significantly (P < 0.001) reduced the volume of gastric content but increased the ... activities of the gastric tissue intoxicated by ethanol. UHPLC analysis of MMMC confirmed the presence several flavonoid-based ... and enzymatic and non-enzymatic antioxidant studies while the gastric juice content and tissue from the latter assay were ... and via modulation of the gastric tissue endogenous antioxidant system. ...
... gastric acidity determination MeSH E01.450.150.470 - limulus test MeSH E01.450.150.810 - urinalysis MeSH E01.450.230.050 - ... gastric acidity determination MeSH E01.370.372.310 - gastrointestinal transit MeSH E01.370.372.450 - lactose tolerance test ... blood volume determination MeSH E01.370.370.170 - capillary fragility MeSH E01.370.370.380 - heart function tests MeSH E01.370. ... blood pressure determination MeSH E01.370.600.115 - body constitution MeSH E01.370.600.115.100 - body weights and measures MeSH ...
PPIs act on proton pumps by blocking acid production, thereby reducing gastric acidity. When ADDERALL XR (20 mg single-dose) ... Amphetamines may interfere with urinary steroid determinations.. Drug Abuse And Dependence. Controlled Substance. ADDERALL XR ...
Gastric Acidity Determination. Gastric analysis for determination of free acid or total acid. ... Parietal Cells, Gastric. Rounded or pyramidal cells of the GASTRIC GLANDS. They secrete HYDROCHLORIC ACID and produce gastric ... Vagotomy, Proximal Gastric. Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) ... and PPIs are widely used to treat gastric ulcer (GU). However, if the action of promoting gastric mucosal regener... ...
PPIs act on proton pumps by blocking acid production, thereby reducing gastric acidity. When MAS-ER Capsules (20 mg single-dose ... Amphetamines may interfere with urinary steroid determinations.. * 8 USE IN SPECIFIC POPULATIONS ...
The effect of a single intravenous massive dose (30.0-600.0mg) atropine on gastric secretion in man. ...
Moore EW, Scarlata T. The determination of gastric acidity by the glass electrode. Gastroenterology 1965;49:178-88. ... Normally, gastric acid output is measured by titrating acidity to pH 7.0; however, titration to pH 7.0 will not detect acid ... METHODS: Gastric acidity and acid output (AO) were measured overnight in 12 subjects, with and without omeprazole, before and 1 ... Undissociated acidity of human gastric juice. Gastroenterology 1970;58:345-51.. 31. Bugnoli M, Bayeli P, Rappuoli R, et al. ...
Gastric Acidity Determination / Gastric Juice Language: English Journal: Indian Pediatr Year: 1979 Type: Article ... Gastric Acidity Determination / Gastric Juice Language: English Journal: Indian Pediatr Year: 1979 Type: Article ... A study of gastric acidity in newborns. A study of gastric acidity in newborns. ...
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Gastric Acidity Determination / Gastritis / Anemia ... Full text: Available Index: IMSEAR (South-East Asia) Main subject: Humans / Gastric Acidity Determination / Gastritis / Anemia ... The gastric acidity and the incidence of chronic atrophic gastritis in anemia. ... The gastric acidity and the incidence of chronic atrophic gastritis in anemia. ...
PPIs act on proton pumps by blocking acid production, thereby reducing gastric acidity. When Adderall XR® (20 mg single-dose) ... Amphetamines may interfere with urinary steroid determinations.. Carcinogenesis/Mutagenesis and Impairment of Fertility. No ... Management of acute amphetamine intoxication is largely symptomatic and includes gastric lavage, administration of activated ...
Acidity Determinations, Gastric Determination, Gastric Acidity Determinations, Gastric Acidity Gastric Acidity Determinations ... Gastric. Acidity Determinations, Gastric. Determination, Gastric Acidity. Determinations, Gastric Acidity. Gastric Acidity ... Gastric Acidity Determination Entry term(s). Acidity Determination, Gastric ... Gastric Acidity Determination - Preferred Concept UI. M0009001. Scope note. Gastric analysis for determination of free acid or ...
Gastric Acidity Determination*. *Gastritis/etiology*. *Gastritis/pathology. *Humans. *Hydrogen-Ion Concentration. *Male ... However, fundal histology and fasting gastric pH were normal. On the 8th day fasting gastric pH rose to 7.6. On day 11 C. ... Campylobacter pyloridis was ingested by a volunteer who had a histologically normal gastric mucosa and fasting gastric pH ... Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH.. Morris A, Nicholson G. ...
  • Acid secretory parameters like gastric volume, pH, total acidity and free acidity were measured in pylorus ligation model, whereas numbers of ulcers, ulcers score and ulcer index was measured in pylorus ligated and indomethacin treated rats. (
  • 0.05) decreased the gastric volume, total acidity, free acidity and increase in the pH of the gastric fluid in pylorus-ligated rats. (
  • Macroscopic analysis of the stomach, evaluation of gastric content parameters such as volume, pH, free and total acidity, protein estimation, and quantification of mucus were carried out. (
  • Quantitative estimations of free and total acidity were made by titration with 0.01 mol/L sodium hydroxide and specific indicators. (
  • Ethanol induced gastric ulcers was used for this study and analysed for gastric volume, ulcer score pH, free and total acidity and sodium and potassium ions. (
  • Gastro protective potential can be measured by the determination of pH, Gastric content, free and total acidity. (
  • The results of the present study showed that the chloroform extract of Phoenix dactylifera leaves possessed gastro protective activity as evidenced by its significant inhibition of mean ulcer score and ulcer index and a marked decrease in gastric content, free and total acidity levels and increase in pH in a dose dependant manner. (
  • Free acidity, total acidity, basal acid output, serum pepsinogen I, gastric mucosal blood flow (GMBF) and gastrin were significantly lower in group II, whereas serum gastrin and somatostatin staining were significantly higher. (
  • After 4 hour in pyloric ligation method induced method rat was sacrificed and stomach wasremoved for observation of various biochemical and histo-pathological parameters such as pH ofgastric content, free acidity, total acidity and ulcer index were determined. (
  • It lowered the free and total acidity and ulcer index as compared to control group. (
  • BACKGROUND: Endothelial nitric oxide synthase (eNOS) has previously been detected in the glandular part of the human gastric mucosa. (
  • Injection of purified scorpion toxin in rats induces a dramatic increase in gastric acid and pepsin secretion (2,3) as well as the production of hemorrhagic lesions of the gastric mucosa (4). (
  • Vagal denervation of that part of the STOMACH lined with acid-secreting mucosa (GASTRIC MUCOSA) containing the GASTRIC PARIETAL CELLS. (
  • Campylobacter pyloridis was ingested by a volunteer who had a histologically normal gastric mucosa and fasting gastric pH recordings of less than 2. (
  • Gastric ulcer is a common disorder where discontinuity in the gastric mucosa is observed. (
  • It is also advisable to perform FGDS, in which erosion of the gastric mucosa or peptic ulcer is often diagnosed. (
  • Effect of histamine H2 antagonism by metiamide on the response of the canine gastric mucosa to acid and bile salt. (
  • Increased acid production from gastric mucosa is responsible for peptic ulceration in majority of the patients. (
  • There was no detectable difference in the grade or activity of gastritis in TNF-R1 −/− mice when they were compared with wild-type mice, but the number of lymphoid aggregates was slightly reduced in the gastric mucosa of TNF-R1 −/− mice. (
  • Helicobacter pylori colonization of the human gastric mucosa has been shown to be the main causative agent of chronic active type B gastritis and is closely associated with peptic and duodenal ulcer disease ( 6 , 23 , 42 , 58 ), as well as gastric carcinoma ( 19 , 45 ) and low-grade gastric B-cell lymphoma of the MALT type ( 19 , 30 , 59 ). (
  • Gastric ulcer, one of the most widespread, acid and pepsin in the stomach normally do not produce is believed to be due to an imbalance between aggressive damage or symptoms because of intrinsic defense and protective factors.2 The gastric mucosa is mechanisms. (
  • Administration of extract at both dose levels has shown a significant increase in potassium and sodium ion concentration in the gastric juice of pylorus ligation group. (
  • There is a greater demand for its fruit juice in treatment for different kinds of illnesses such as diabetes, arthritis, cancer, gastric ulcer, and other heart disease [ 5 ]. (
  • He identified free muriatic acid (hydrochloric acid) in the gastric juice of various animals and humans after a meal and suggested that it was derived from the common salt of the blood by the force of galvanism (electricity). (
  • Before this finding, Prout favored phosphoric acid as responsible for the acidity of gastric juice. (
  • Beaumont studied the appearance and function of the exposed living stomach over a number of years, and provided new information about the nature of gastric juice and the process of digestion in the stomach. (
  • He published his findings in Experiments and Observations on Gastric Juice and the Physiology of Digestion (1833). (
  • Beaumont recognized the acid character of the gastric juice in response to food and alcohol. (
  • Stomach of rats from the former assay was collected and subjected to the macroscopic and microscopic observations, and enzymatic and non-enzymatic antioxidant studies while the gastric juice content and tissue from the latter assay were subjected to the antisecretory activity study. (
  • GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE. (
  • Hydrochloric acid present in GASTRIC JUICE. (
  • Concentrations of ammonia, total bile acids, and proteins in gastric juice aspirates were also assayed, as were plasma omeprazole levels. (
  • The determination of the acidity of gastric juice often reveals its decrease. (
  • Gastric juice can be aspirated through an oral or nasogastric tube (polyvinyl chloride, silicone, or polyurethane) or during endoscopy. (
  • The end is perforated with small holes to allow entry of gastric juice into the tube. (
  • A syringe is attached to the outer end of the tube for the aspiration of gastric juice. (
  • After the collection of gastric juice for determination of BAO , patient is given a subcutaneous or intramuscular injection of pentagastrin (6 μg/kg of body weight), and immediately afterwards, gastric secretions are aspirated at 15-minute intervals for 1 hour (for estimation of MAO or PAO) . (
  • The hydrochloric acid and paper acidity in the gastric juice can be measured. (
  • A negative association between fasting ad (lettuce, tomato and cucumber with ol- serum gastrin level and gastric acidity has ive oil or corn oil and lemon juice or vinegar been observed [ 10 ]. (
  • The cause of ulceration in patients is mainly due to hyper secretion of gastric juice and also due to hyper secretion of pepsin. (
  • Though recently the mitochondrial bioenergetic coenzyme (Co)Q10 has been shown to protect against indomethacin-induced gastric ulceration, yet the full mechanistic cassettes have not been investigated. (
  • The current investigation shows that CoQ10 guards against gastric ulceration via its partial inhibition of titratable acidity and peptic activity, as well as enhancement of mucin secretion due to both gastric mucosal nitric oxide and glutathione replenishment, especially at the higher dose levels. (
  • Oral administration of EEMT at a dose of 200 and 400 mg/kg significantly prevented the occurrence of aspirin pyloric ligation and cysteamine-induced gastric and duodenal ulceration. (
  • Relief of heartburn Short-term and maintenance therapy of gastric and duodenal ulcers With nonsteroidal anti-inflammatory drugs (NSAIDs) to reduce the risk of ulceration Proton-pump inhibitors (PPIs) are more effective for the prevention of NSAID-induced ulcers. (
  • The objective of the present study was to investigate the antiulcer activity of methanol extract of Oxalis corniculata (whole plant) using pylorus ligation and indomethacin-induced gastric ulceration in Wistar rats. (
  • Gastric ulceration is a cause of economic loss and a source of welfare concern worldwide. (
  • Both of them conducted a seven year study of H.pylori and finally found that it causes peptic ulceration, commonly called as acidity that leads to stomach ulcers. (
  • They secrete HYDROCHLORIC ACID and produce gastric intrinsic factor, a glycoprotein that binds VITAMIN B12. (
  • Gastric fluid is produced by numerous cells (such as parietal, chief, mucus-secreting, and hormone-secreting cells) in the gastric glands and is composed of water, electrolytes, hydrochloric acid, various enzymes, mucus, and intrinsic factors (Gropper et al. (
  • Levels of the substances homocysteine and methylmalonic acid typically are high in persons with pernicious anemia, while gastric secretions lack hydrochloric acid (achlorhydria). (
  • BACKGROUND: The experience with long-term treatment of peptic ulcer with omeprazole is still scant, but the possibility cannot be excluded that its better pharmacodynamic effect on gastric acidity also has a positive result in the relapse rate. (
  • The NSAID reduced gastric volume and mucin content, but increased titratable acidity, acid output, and peptic activity. (
  • Although treatment of peptic ulcer depends on the cause and may need antibiotics to kill H. pylori , secretion of gastric acid is still believed to remain as the central component of this disease. (
  • To examine the mechanisms responsible for the interaction between H. pylori and omeprazole, we studied the changes in nocturnal gastric acidity and acid output produced by omeprazole in 12 subjects with H. pylori infection, but without peptic ulcer disease, both before and after cure of their infection. (
  • Peptic ulcers occur in that part of the gastrointestinal tract which is exposed to gastric acid and pepsin, i.e., the stomach and duodenum. (
  • Peptic ulcer is mostly produced due to the over production of gastric acid. (
  • Nagadani Kalyani*, R. Kiran Jyothi, Dr. K.B Chandra Sekhar Department of Pharmaceutical Analysis, JNTUA- Oil Technological and Pharmaceutical Research Institute, Ananthapuramu-515001, A. P, India A B S T R A C T Omeprazole is a proton pump inhibitor ﴾PPI﴿ and a potent inhibitor of gastric acidity which is mostly used in the therapy of gastroesophageal reflux and peptic ulcer disease. (
  • Gastric acid , peptic activities, mucin levels, FT/IC-ATPase activities and the gastrin level were analyzed. (
  • The drugs currently used in the treatment of gastric ulcers are antacids, anticholinergics, proton pump inhibitors and H2-receptor antagonists [ 4 , 5 ]. (
  • Currently, the prevention and treatment of gastric ulcers has gained lots of interest and became and important challenge confronting medicine nowadays. (
  • A multinational consortium, led by Institut Pasteur scientists, has made a breakthrough in understanding the genetics of sex determination in humans. (
  • Given its dual role in ribosome biogenesis and sex determination, protein DHX37 has forced us to reconsider sex-detemination in humans. (
  • EEMT) against aspirin pyloric ligation-induced gastric ulcer model and cysteamine-induced duodenal ulcer in Wistar rats. (
  • Thus, the present study pertains to the evaluation of antiulcer efficacy of ethanol leaf extract of Morinda tinctoria (EEMT) against aspirin pyloric ligation-induced gastric ulcer model and cysteamine-induced duodenal ulcer in Wistar rats. (
  • The mechanism of gastroptotection of EAF was further investigated using pylorus ligation-induced gastric lesion rat model (100, 250, and 500 mg/kg). (
  • doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays. (
  • 0.001) reduced the volume of gastric content but increased the gastric wall mucus content in the pyloric-ligation test. (
  • One of the suitable models to study the effect of extract/compound on gastric acid secretion under experimental condition is the pyloric ligation assay in rats. (
  • Another study has suggested that in chronically vagotomized rats the acid response to pylorous ligation is caused by intramural reflexes activated by the gastric distension. (
  • The antiulcer study was carried out in acetic acid induced chronic gastric, pylorus ligation induced gastric, ethanol induced gastric, stress induced gastric, and indomethacin induced gastric ulcers. (
  • 13 ] was the first to report that supplementation with CoQ10 in the diet aids healing of chronic acetic acid gastric ulcers in rats via hampering hypoxia. (
  • The effects of a fraction (T1) of Tityus serrulatus scorpion venom prepared by gel filtration on gastric emptying and small intestinal transit were investigated in male Wistar rats. (
  • Inhibition of both gastric emptying and intestinal transit in rats injected with scorpion toxin suggests an increased resistance to aboral flow, which might be caused by abnormal neurotransmitter release or by the local effects of venom on smooth muscle cells. (
  • More recently, it was shown that toxin- g from T. serrulatus induces a sustained slowing of gastric emptying in rats (6). (
  • In the present study, we show that injection of a partially purified fraction from T. serrulatus venom in anesthetized rats is followed by a remarkable inhibition not only of gastric emptying but also of small intestinal transit. (
  • Combination therapy with polydeoxyribonucleotide and proton pump inhibitor enhances therapeutic effectiveness for gastric ulcer in rats. (
  • Antioxidant and anti-inflammatory activities of alpha lipoic acid protect against indomethacin-induced gastric ulcer in rats. (
  • In conclusion, prevention of gastric lesions in rats by VCO was found to increase the mucous and decrease the acid volume, total acid contents and ulcer scoring. (
  • The gastric ulcers were induced in rats of either sex weighing between 130-150 by administrating absolute ethanol (8ml/kg). (
  • The present study was undertaken to determine the effect of gum arabic on gastric ulcers in rats. (
  • Furthermore, gum arabic is reported to prevent development of indomethacin induced gastric ulcers in rats [ 10 ]. (
  • the present study was envisaged to explore its effect on stomach in normal animals and on different experimentally induced gastric ulcer models in rats. (
  • No standard methods exist for determining the onset of action of gastric antisecretory agents in human subjects. (
  • At the end of the 1st, 3rd, and 6th month of these maintenance treatments 24-h gastric pH-metry was repeated to assess the antisecretory effect of each regimen over time. (
  • MMMC, at the ratio of 1:1 ( v /v), exerts gastroprotective activity partly by activating its antisecretory and antioxidant activities, and via modulation of the gastric tissue endogenous antioxidant system. (
  • The effect of ammonia in increasing gastric pH should be most evident during potent antisecretory therapy when the concentration of hydrogen ions is lower (2), but it is not known whether H. pylori produces sufficient ammonia to cause the augmented omeprazole-induced increase in gastric pH. (
  • It was concluded that gum arabic have beneficial effect in preventing and healing of gastric ulcers due to both gastric antisecretory and cytoprotective effects. (
  • This study was undertaken to find out the effects of extract from Myristica Fragrans which contains documented natural Calcium channel blocker and Verapamil on volume and acidity of Carbacol induced gastric section. (
  • Induction of hypercalcaemia through intravenous administration of calcium is usually associated with increased gastric volume and acidity. (
  • So this study was planned to evaluate the effects of extract from Myristica fragrans and calcium channel blocker Verapamil on the volume and acidity of Carbachol induced gastric secretion. (
  • An imbalance between the aggressive factors such as acid and pepsin secretion, H. pylori, refluxed bile, deliverance of leukotrienes and reactive oxygen species (ROS) and mucosal protective factors that include bicarbonate secretion, mucus-bicarbonate barrier, surface active phospholipids, prostaglandins (PGs), mucosal blood circulation, cell renewal and relocation, non-enzymatic and enzymatic antioxidants and some growth factors [ 4 ] leads to gastric damages. (
  • These are gastric acid and pepsin are necessary, but usually not considered safer because of the natural ingredients with sufficient, pathogenic factors. (
  • 1 Ulcers These agents have been implicated in the pathogenesis of are sores on the lining of the digestive tract which consists gastric ulcer, including enhanced gastric acid and pepsin of the esophagus, stomach, duodenum and intestines. (
  • CONCLUSION: Our results show that NO inhibits gastric acid secretion in isolated human gastric glands, and that there is endogenous formation of NO within the glandular epithelium in the vicinity of the parietal cells. (
  • Gastrotem forms a stable disulfide bond with the sulfhydryl group of the hydrogen-potassium (H+ - K+) ATPase found on the secretory surface of parietal cells, thereby inhibiting the final transport of hydrogen ions (via exchange with potassium ions) into the gastric lumen and suppressing gastric acid secretion. (
  • TAKECAB, discovered by Takeda, is a new medicine for treating acid-related diseases with a novel mechanism of action called potassium-competitive acid blockers (P-CABs) which competitively inhibits the binding of potassium ions to H+,K+-ATPase (also known as the proton pump) in the final step of gastric acid secretion in gastric parietal cells. (
  • This study is used by the Digestive Diseases Branch to evaluate patients with suspected abnormalities in the secretion of gastric acid. (
  • The method causes copious secretion of gastric acid (Shay et al. (
  • The main action of proton pump inhibitors (PPIs) is to inhibit gastric acid secretion, and PPIs are widely used to treat gastric ulcer (GU). (
  • The present survey uses a dynamic gastric and small intestinal model to assess the survival of one pathogenic ( Escherichia coli O157:H7 EDL 933) and three lactobacilli bacteria with probiotic potential ( Lactobacillus rhamnosus GG, L. pentosus TOMC-LAB2, and L. pentosus TOMC-LAB4) during their passage through the human gastrointestinal tract using fermented olives as the food matrix. (
  • On the contrary, the three lactobacilli species assayed showed a considerable resistance to the gastric digestion, but not to the intestinal one, which affected their survival, and was especially evident in the case of both L. pentosus strains. (
  • experience has demonstrated also thatthe lime salts are quite incapable of improving either osteomalacia has also been proposed to treat with lime cases in which the bloodseemed less capable of clotting than normally - particularly haemo-philia, and the treatment has been extended to aneurism, haemoptysis,and gastric and intestinal haemorrhage. (
  • Most secretion, inhibition of prostaglandin synthesis and cell ulcers are located in the duodenum and they are called proliferation growth, diminished gastric blood flow and duodenal ulcers. (
  • In a 2009 meta-analysis comparing the net benefit of proton pump inhibitors and ranitidine to reduce the risk of aspiration before anesthesia, ranitidine was found to be more effective than proton pump inhibitors in reducing the volume of gastric secretions. (
  • This is followed by aspiration of gastric secretions at 15-minute intervals for 1 hour (i.e. total 4 consecutive samples are collected). (
  • The Effect of Ammonia on Omeprazole-Induced Reduction of Gastric Acidity in Subjects With Helicobacter pylori Infection // The American Journal of Gastroenterology. (
  • Introduction: Helicobacter pylori is a microaerophilic, spiral shaped, unipolar flagellated, gram negative organism which has high tropism towards gastric epithelial cells and may lead to a severe form of gastroduodenal disease. (
  • Approximately, 80% of gastric adenocarcinomas are associated with Helicobacter pylori infection and occur secondary to associated gastritis [8]. (
  • Increased gastric production of interleukin 8 and tumor necrosis factor alpha (TNF-α) has been implicated in the pathogenesis of Helicobacter pylori -associated gastroduodenal disease. (
  • When onset was defined in terms of a particular decrease in gastric acid concentration for the group as a whole or for individual subjects, there was an important variation in the relative times of onset of ranitidine 75 mg and famotidine 10 mg. (
  • When administered after a meal, the onset of action of ranitidine and famotidine on gastric pH can be determined for individual subjects as well as for the group as a whole. (
  • 21-76%), an effect which was not modified by gastric secretion blockade with ranitidine. (
  • It also produced a significant protection in the development of the gastric ulcers in other gastric ulcer models and also potentiated the antiulcer effect of ranitidine. (
  • Barriers to the reflux of gastric contents into continuously exposed to potentially injurious agents such the esophagus comprise the primary esophageal defense. (
  • However, limited literature exists about its efficacy in combating gastric mucosal injury. (
  • The drug increases gastric pH , but generally has no effect on gastric volume. (
  • E3710 is a novel PPI discovered by Eisai as a successor to Pariet, and compared to existing PPIs, potentially provides a stronger and a longer-lasting inhibitory effect on gastric acid secretion. (
  • Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands. (
  • Ingestion of Campylobacter pyloridis causes gastritis and raised fasting gastric pH. (
  • C. pyloridis can cause an acute upper gastrointestinal illness associated with histological gastritis and an increase in fasting gastric pH. (
  • The primary aim of the study was to test the hypothesis that ammonia produced by H. pylori is sufficient to account for the greater increase in gastric pH produced by omeprazole (20 mg daily) before eradication, compared with the omeprazole-induced increase observed after eradication. (
  • Gastric carcinoid tumors comprise 7% of all gastrointestinal carcinoids and have significantly increased in incidence over the past few decades. (
  • Tests of gastric acid secretion have been used in the diagnosis of upper gastrointestinal lesions and to help select the type of surgical procedure for gastric and duodenal ulcers, but the tests have decreased in importance because of their limited diagnostic sensitivity and specificity. (
  • These mechanisms of action might be responsible for the therapeutic change in gastric acidity as demonstrated by repeated fasting gastric pH measurements, and by the relief of gastrointestinal symptoms as noted by the patient. (
  • First, niacin is an effective anti-stress agent 12 and therefore any reduction in gastrointestinal symptoms might simply be due to stress reduction rather than through the augmentation of gastric acid secretion. (
  • Its acidic properties alone might be the reason for any improvement in gastrointestinal symptoms, especially, if they were initially related to a deficiency in gastric acid secretion. (
  • Gastric acidity and acid output (AO) were measured overnight in 12 subjects, with and without omeprazole, before and 1 and 6 months after cure of H. pylori infection. (
  • To assess gastric acid secretion, acid output from the stomach is measured in a fasting state and after injection of a drug which stimulates gastric acid secretion. (
  • This study examined gastric secretory, hormonal and mucosal changes in individuals with portal hypertensive gastropathy (PHG) due to schistosomal hepatic fibrosis (SHF) before and after sclerotherapy. (
  • Gastric mucosal lesions are common in individuals with portal hypertension and can be an important cause of blood loss, which is generally slow and insidious but can be massive and occasionally fatal [3]. (
  • Moreover, preadministration with the nonselective nitric oxide synthase inhibitor, L-NAME, boosted ulcer formation that was associated by suppression of gastric mucosal nitric oxide in CoQ10 and pantoprazole-treated groups. (
  • The purpose of this study is to compare Prilosec OTC® and Zegerid® in their effects on gastric acid suppression. (
  • The objective of this study is to compare Prilosec OTC® to Prevacid® for gastric acid suppression. (
  • The purpose of this study is to compare the gastric acid suppression profile among different regimen (Oral Vs Intravenous)of administration of proton pump inhibitor - Esomeprazole by 24hou. (
  • Ethyl acetate fraction significantly raised the pH of gastric content and thus reducing the level of acidity in the stomach. (
  • The present study was conducted to investigate the influence of exogenously and endogenously derived NO on histamine- and cAMP-stimulated gastric acid secretion in isolated human oxyntic glands. (
  • METHODS: Oxyntic glands were isolated from human gastric biopsies and were subsequently pre-treated with NO donors and nitric oxide synthase inhibitors and then exposed to histamine or dibutyryl-cAMP (db-cAMP). (
  • Rounded or pyramidal cells of the GASTRIC GLANDS. (
  • The term PUD generally refers to a spectrum of disorders that includes gastric ulcer (GU), pyloric channel ulcer, duodenal ulcer (DU), and postoperative ulcers at or near the site of surgical anastomosis [ 1 ]. (
  • At a time when Roentgen rays were still a diagnostic novelty, gastric disorders were investigated with a wide variety of test meals. (
  • This technique has been widely used in the anti-ulcer studies to investigate the mechanism involve by stimulating gastric secretion and collection of gastric juices. (
  • METHODS: Twenty patients with endoscopically proven duodenal ulcer were studied by means of 24-h gastric pH-metry both in basal conditions and on the 5th day of acute treatment with 40 mg omeprazole in the morning. (
  • For ulcer treatment, a night-time dose is especially important - as the increase in gastric/duodenal pH promotes healing overnight when the stomach and duodenum are empty. (
  • Later, it served to aspirate the stomachs of patients with gastric retention. (
  • Furthermore, nitric oxide (NO) has been shown to influence gastric secretion in various animal models. (
  • Indomethacin evoked gastric ulcerations that were associated by decreased gastric mucosal nitric oxide and glutathione levels. (
  • Little is known about the role of tumor necrosis factor-alpha (TNF-α), plasminogen activator inhibitor-1 (PAI-1), and inducible nitric oxide synthase (iNOS) in the gastric ulcer and the effect of alp. (
  • H. pylori is thought to survive in the acidic gastric milieu because it produces ammonia, which can neutralize surrounding acid and increase the local pH. (
  • Gastro-oesophageal reflux disease (GORD) results from an abnormally prolonged dwell time of acidic gastric contents in the oesophagus. (
  • Hyaluronic acid-modified polyamidoamine dendrimer G5-entrapped gold nanoparticles delivering METase gene inhibits gastric tumor growth via targeting CD44+ gastric cancer cells. (
  • In the present study we used a mouse model to demonstrate whether loss of the tumor necrosis factor receptor 1 (TNF-R1) function leads to differences in gastric inflammation or the systemic immune response in H. pylori infection. (
  • We therefore suggest that TNF-R1-mediated TNF-α signals might support a systemic humoral immune response against H. pylori and that the gastric inflammatory response to H. pylori infection seems to be independent of TNF-R1-mediated signals. (
  • is metformin 500 mg a high dose Food and/or rNA, especially by reducing resting 3 267 They stimulate gastric irritants. (