Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Gas Gangrene: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.Penile Diseases: Pathological processes involving the PENIS or its component tissues.Toes: Any one of five terminal digits of the vertebrate FOOT.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Clostridium perfringens: The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.Scrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Debridement: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)Clostridium septicum: A species of gram-positive bacteria in the family Clostridiaceae. Infections have a strong association with malignancies and also with GAS GANGRENE.Fasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Foot Ulcer: Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Genital Diseases, Male: Pathological processes involving the male reproductive tract (GENITALIA, MALE).Noma: A severe gangrenous process occurring predominantly in debilitated and malnourished children, especially in underdeveloped countries. It typically begins as a small vesicle or ulcer on the gingiva that rapidly becomes necrotic and spreads to produce extensive destruction of the buccal and labial mucosa and tissues of the face, which may result in severe disfigurement and even death. Various bacteria have been implicated in the etiology. (Dorland, 27th ed)Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Toe Phalanges: Bones that make up the SKELETON of the TOES, consisting of two for the great toe, and three for each of the other toes.Lower Extremity: The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)Skin UlcerArterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Tibial Arteries: The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Streptococcus pyogenes: A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Neuroendocrinology: The study of the anatomical and functional relationships between the nervous system and the endocrine system.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Information Centers: Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Fat Body: A nutritional reservoir of fatty tissue found mainly in insects and amphibians.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Dictionaries, MedicalDictionaries, ChemicalPhonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)Language: A verbal or nonverbal means of communicating ideas or feelings.Soft Tissue Infections: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.Fournier Gangrene: An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.
Gangrenous cystitis: a rare cause of colovesical fistula. (1/271)
A case of gangrenous cystitis presenting as a colovesical fistula in an elderly woman is described. The literature on this rare condition is reviewed. (+info)Traditional bone setter's gangrene. (2/271)
Traditional bone setter's gangrene (TBSG) is the term we use to describe the sequelae sometimes seen after treatment with native fracture splints. Twenty five consecutive complications were recorded in 25 patients aged between 5-50 years with a median age of 10 years. The major complication of the native fracture splint treatment was distal limb gangrene necessitating proximal amputations in 15 cases. (+info)Thigh isosulfan blue injection in the treatment of postoperative lymphatic complications. (3/271)
Postoperative lymphatic complications after infrainguinal revascularization are troublesome and potentially serious complications. Vital dye injection into the web spaces of the foot has been recommended as a simple and reliable method to identify lymphatic channel disruption before groin exploration. Such distal injections, however, are not always successful. We describe a modified technique using a proximal thigh injection with isosulfan blue, which is faster and more useful than the distal web space method. (+info)Efficacy of dorsal pedal artery bypass in limb salvage for ischemic heel ulcers. (4/271)
PURPOSE: Although pedal artery bypass has been established as an effective and durable limb salvage procedure, the utility of these bypass grafts in limb salvage, specifically for the difficult problem of heel ulceration, remains undefined. METHODS: We retrospectively reviewed 432 pedal bypass grafts placed for indications of ischemic gangrene or ulceration isolated to either the forefoot (n = 336) or heel (n = 96). Lesion-healing rates and life-table analysis of survival, patency, and limb salvage were compared for forefoot versus heel lesions. Preoperative angiograms were reviewed to evaluate the influence of an intact pedal arch on heel lesion healing. RESULTS: Complete healing rates for forefoot and heel lesions were similar (90.5% vs 86.5%, P =.26), with comparable rates of major lower extremity amputation (9.8% vs 9.3%, P =.87). Time to complete healing in the heel lesion group ranged from 13 to 716 days, with a mean of 139 days. Preoperative angiography demonstrated an intact pedal arch in 48.8% of the patients with heel lesions. Healing and graft patency rates in these patients with heel lesions were independent of the presence of an intact arch, with healing rates of 90.2% and 83.7% (P =.38) and 2-year patency rates of 73.4% and 67.0% in complete and incomplete pedal arches, respectively. Comparison of 5-year primary and secondary patency rates between the forefoot and heel lesion groups were essentially identical, with primary rates of 56.9% versus 62.1% (P =.57) and secondary rates of 67.2% versus 60.3% (P =.50), respectively. CONCLUSION: Bypass grafts to the dorsalis pedis artery provide substantial perfusion to the posterior foot such that the resulting limb salvage and healing rates for revascularized heel lesions is excellent and comparable with those observed for ischemic forefoot pathology. (+info)Nontraumatic lower extremity amputations in the Medicare end-stage renal disease population. (5/271)
BACKGROUND: Nontraumatic lower limb amputation is a serious complication of both diabetic neuropathy and peripheral vascular disease. Many people with end-stage renal disease (ESRD) suffer from advanced progression of these diseases. This study presents descriptive information on the rate of lower limb amputation among people with ESRD who are covered by the Medicare program. METHODS: Using hospital bill data for the years 1991 through 1994 from the Health Care Financing Administration's ESRD program management and medical information system (PMMIS), amputations were based on ICD9 coding. These hospitalizations were then linked back to the PMMIS enrollment database for calculation of rates. RESULTS: The rate of lower limb amputation increased during the four-year period from 4.8 per 100 person years in 1991 to 6.2 in 1994. Among persons whose renal failure was attributed to diabetic nephropathy, the rates in 1991 and 1994 were 11.8 and 13.8, respectively. The rate among diabetic persons with ESRD was 10 times as great as among the diabetic population at large. Two thirds died within two years following the first amputation. CONCLUSIONS: The ESRD population is at an extremely high risk of lower limb amputation. Coordinated programs to screen for high-risk feet and to provide regular foot care for those at high risk combined with guidelines for treatment and referral of ulceration are needed. (+info)Necrotizing soft tissue infections. (6/271)
Necrotizing soft tissue infections are a group of highly lethal infections that typically occur after trauma or surgery. Many individual infectious entities have been described, but they all have similar pathophysiologies, clinical features, and treatment approaches. The essentials of successful treatment include early diagnosis, aggressive surgical debridement, antibiotics, and supportive intensive treatment unit care. The two commonest pitfalls in management are failure of early diagnosis and inadequate surgical debridement. These life-threatening infections are often mistaken for cellulitis or innocent wound infections, and this is responsible for diagnostic delay. Tissue gas is not a universal finding in necrotizing soft tissue infections. This misconception also contributes to diagnostic errors. Incision and drainage is an inappropriate surgical strategy for necrotizing soft tissue infections; excisional debridement is needed. Hyperbaric oxygen therapy may be useful, but it is not as important as aggressive surgical therapy. Despite advances in antibiotic therapy and intensive treatment unit medicine, the mortality of necrotizing soft tissue infections is still high. This article emphasizes common treatment principles for all of these infections, and reviews some of the more important individual necrotizing soft tissue infectious entities. (+info)Epidemiology of the incidence of oro-facial noma: a study of cases in Dakar, Senegal, 1981-1993. (7/271)
Oro-facial noma is an oral gangrene occurring in early childhood in extremely poor areas. As many as 70-90% of those with noma die, and to date, there is no satisfactory treatment to fight this disease. Within the context of the World Health Organization international program against noma, a 13-year retrospective study based on clinical records was carried out in Dakar, Senegal in an attempt to understand the epidemiology of noma. Between 1981 and 1993, 199 cases of noma were identified, among them; 36.7% were acute cases and 63.3% showed sequelae. Chronic sequelae of noma were seen in patients 2-41 years of age, but the acute phase of noma was found only in young children (77.7% in those 1-4 years of age, maximum age = 9 years, mean age +/- SD age = 3.4 +/- 1.9 years). A total of 73.1% of the cases with acute disease were reported in the Dakar, Diourbel and Kaolack regions during the dry season (57.0% of the cases). The lesions of progressive noma were localized mainly on the upper lip (42.4%) and the cheek (31.1%). A total of 96.9% of the patients with acute diseases were had poor general health with serious associated diseases; only 20.0% had a good vital prognosis. The development of epidemiologic surveillance programs for noma should be a public health priority in Senegal. (+info)Adjunctive techniques to improve patency of distal prosthetic bypass grafts: polytetrafluoroethylene with remote arteriovenous fistulae versus vein cuffs. (8/271)
PURPOSE: The long-term patency for infrapopliteal bypass grafting with prosthetic material is less than optimal. Our experience demonstrates a 40% patency at 2 years for these grafts. Several adjuvant techniques have been developed to improve patency rates, two of which are a remote distal arteriovenous fistula and the creation of a distal vein cuff. This study summarizes our experience with these two techniques. METHODS: Between 1987 and 1998, 107 bypass graftings were performed to the below-knee popliteal or tibial vessels with the use of polytetrafluoroethylene. One group (48 bypass grafts) had polytetrafluoroethylene with adjuvant distal arteriovenous fistula (DAVF), and a second group (59 bypass grafts) was reconstructed with a distal vein cuff (DVC). The type of bypass grafting that was performed was based on surgeon experience and preference. Indications and demographics were similar in the two groups. All patients underwent the operation for limb-threatening ischemia, including gangrene (DAVF, 23%; DVC, 9%), ulceration (DAVF, 27%; DVC, 51%), and rest pain (DAVF, 50%; DVC, 40%). RESULTS: The primary patency rate was 48% and 38% at 3 years for DAVF and DVC, respectively. Secondary patency was 48% and 47% at 3 years, with limb salvage rates of 76% and 92% for DAVF and DVC, respectively (P <.05). Attempted thrombectomy without continuation of patency was undertaken in two patients with a failed DAVF. Attempts at restoration after thrombosis were made in eight patients with failed DVCs. Five patients underwent thrombectomy, of which four procedures were successful. Three patients had thrombolytic therapy, and two of these remained patent. CONCLUSION: Adjuvant techniques, including DAVF and DVC, produce acceptable long-term patency and limb salvage rates in bypass grafts performed to the below-knee popliteal and tibial vessels. This study suggests that DVCs may offer improved limb salvage rates and a greater opportunity for revision when bypass graft failure occurs. (+info)
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Fournier'sInfectionNecrotizing fasciitisRisk of gangreneTypes of gangreneExtremitiesBacteriaClostridiumNecrosisBacterialInternal gangreneAmputationTissuesFournier2018SepsisWoundsDiagnosisDiabetes mellitusDevelop gangreneOccursBody tissueMoistTissue deathToesComplicationsOccurArteriesForm of gangreneSigns of gangreneAntibioticsTraumaMyonecrosisComplicationVascularTreatmentSevereFeverPenisDevelops2019Cases of gas gangreneCommon symptoms of gangreneDiseasesHerniaSymmetric peripheral gangreneRapidlyArteryMorbidity and mortaDeathWoundKind of gangrene
Fournier's54
- Other types, such as Fournier's gangrene and internal gangrene, are less common . (medicalnewstoday.com)
- Fournier's gangrene is caused in the genitalia. (news-medical.net)
- When gangrene affects the penis and the genitalia it is called Fournier's gangrene. (news-medical.net)
- What Is Fournier's Gangrene? (webmd.com)
- But with Fournier's gangrene, your genitals and the area around them are affected. (webmd.com)
- Fournier's gangrene involves an infection in the scrotum (which includes the testicles), penis , or perineum. (webmd.com)
- Men are 10 times more likely than women to have Fournier's gangrene. (webmd.com)
- Fournier's gangrene is even rarer in children. (webmd.com)
- Fournier's gangrene usually happens because of an infection in, or near, your genitals. (webmd.com)
- Doctors can find the cause of Fournier's gangrene in about 90% of the cases. (webmd.com)
- Fournier's gangrene, rare today, probably killed Herod, said Dr. Jan Hirschmann of the University of Washington medical school, who examined Herod's case history. (latimes.com)
- This manuscript outlining Fournier's initial series of fulminant perineal gangrene provides a fascinating insight into both the societal background and the practice of medicine at the time. (medscape.com)
- The aim of our study was to describe the epidemiologic, diagnostic and therapeutic aspects of Fournier's gangrene. (scirp.org)
- Patients and methods: We have carried out a retrospective study with 14 patients with Fournier's gangrene, who were treated from January 2011 to November 2013 at the Urology A Department of Ibn Sina University Hospital, Rabat, Morocco. (scirp.org)
- Conclusion: Fournier's gangrene remains, despite the multidisciplinary medical management, a serious affection associated with high mortality. (scirp.org)
- Eke, N. (2000) Fournier's Gangrene: A Review of 1726 Cases. (scirp.org)
- Biyani, C.S., Mayor, P.E. and Powell, C.S. (1995) Case Report: Fournier's Gangrene-Roentnographic and Sonographic Findings. (scirp.org)
- 2006) Fournier's Gangrene: Three Years of Experience with 20 Patients and Validity of the Fournier's Gangrene Severity Index Score. (scirp.org)
- Bronder C.S., Cowey, A. and Hill, J. (2004) Delayed Stoma Formation in Fournier's Gangrene. (scirp.org)
- Mindrup, S.R., Kealey, G.P. and Fallon, B. (2005) Hyperbaric Oxygen for the Treatment of Fournier's Gangrene. (scirp.org)
- Fournier's gangrene is uncommon but increasingly being seen over the last two decades probably due to increasing socioeconomic problems including an upsurge in HIV infection especially in the tropics. (hindawi.com)
- The study retrospectively reviewed all patients with Fournier's gangrene managed in UMTH between January 2007 and December 2012. (hindawi.com)
- Fournier's gangrene is a fulminant synergistic necrotising fasciitis of the perineum and genitalia with poor prognosis especially when associated with HIV and diabetes, requiringprompt and aggressive management for good outcome. (hindawi.com)
- Fournier's gangrene is a rare and often fulminant necrotising fasciitis of the perineum and genital region frequently due to a synergistic polymicrobial infection [ 1 ]. (hindawi.com)
- Some systemic illnesses are associated with Fournier's gangrene. (hindawi.com)
- The study reviewed all patients managed for Fournier's gangrene in UMTH over a 6-year period between January 2007 and December 2012. (hindawi.com)
- The diagnosis of Fournier's gangrene (Figures 1 and 2 ) was made on clinical assessment. (hindawi.com)
- Fournier's gangrene predebridement. (hindawi.com)
- During the process, the inside of his penis had been damaged and he developed Fournier's gangrene, an infection which eats away at human flesh. (dailymail.co.uk)
- Admitted to King George's Medical University Hospital in Lucknow in India's northern Uttar Pradesh, the man was diagnosed with a condition called Fournier's gangrene. (dailymail.co.uk)
- Fournier's gangrene describes necrotising fasciitis, a rare bacterial infection which destroys tissue beyond repair, when it is specifically on the genitals. (dailymail.co.uk)
- Symptoms worsened for 10 days and the man returned to hospital where medics realised he had Fournier's gangrene. (dailymail.co.uk)
- The shocking case is thought to only be the third ever case of someone's entire penis rotting away because of Fournier's gangrene. (dailymail.co.uk)
- The continuing challenge of Fournier's gangrene in the 1990s. (biomedsearch.com)
- During a 12-year period, the clinical and operative records of 14 patients with Fournier's gangrene were analyzed. (biomedsearch.com)
- Although supportive care is required in these patients, the mainstay for treatment of Fournier's gangrene entails an aggressive approach with frequent and extensive soft tissue debridements to control the invasive nature of the infection with delayed wound coverage once the infection has been controlled. (biomedsearch.com)
- Fournier's gangrene an acute gangrenous infection of the scrotum, penis, or perineum following local trauma, operative procedures, an underlying urinary tract disease, or a distant acute inflammatory process. (thefreedictionary.com)
- Despite advances in the evaluation, treatment, and pathophysiological understanding of necrotizing soft-tissue infections, Fournier's gangrene remains a life-threatening urological emergency. (ovid.com)
- Fournier's gangrene is an infective necrotising fasciitis of the external genitalia and perineum associated with significant morbidity and mortality. (scielo.org.za)
- To determine the hospital based mortality and factors associated with non-survival among subjects with a clinical diagnosis of Fournier's gangrene. (scielo.org.za)
- A prospective hospital based observational study on 51patients with a clinical diagnosis of Fournier's gangrene over a 2-year period. (scielo.org.za)
- Fournier's gangrene is a potentially fatal necrotising fasciitis involving the external genitalia, perineum and perianal regions. (scielo.org.za)
- The main objective of this study was to determine the disease related mortality and the factors associated with mortality among patients with a clinical diagnosis of Fournier's gangrene in our environment. (scielo.org.za)
- This study was a hospital based two-year prospective observational study at three tertiary urological centres in Harare, Zimbabwe on 51 consecutive patients admitted with a clinical diagnosis of Fournier's gangrene. (scielo.org.za)
- The diagnosis of Fournier's gangrene was based on history, physical examination and investigations of patients upon admission. (scielo.org.za)
- Fournier's gangrene is a rare process which affects soft tissue in the genital and perirectal area. (hindawi.com)
- Fournier's gangrene is a rare necrotizing fasciitis of the perineal, genital, or perianal regions [ 1 ]. (hindawi.com)
- Fournier's gangrene usually starts with perianal or perineal pain, which is often disproportionate to the physical finding such as swelling or pruritus in the affected area. (hindawi.com)
- In most cases, Fournier's gangrene is a polymicrobial, synergistic, and necrotizing infection of the perineal subcutaneous fascia and male genitalia that originates from the skin, urethra, or rectum. (hindawi.com)
- There is a worldwide consensus that immediate radical excision of the gangrene should be accompanied by intensive care measures in patients with Fournier's Gangrene. (hindawi.com)
- Here we report two cases of septic shock due to Fournier's gangrene which recovered well, treated with surgical debridement, hyperbaric oxygen therapy, and vacuum-assisted closure (VAC) therapy. (hindawi.com)
- To report the development of an ultimately fatal occurrence of Fournier's gangrene in a rectal cancer patient undergoing neoadjuvant radiotherapy without chemotherapy. (springer.com)
- The patient died 6 days after completion of radiotherapy due to septic shock associated with Fournier's gangrene reaching from the right buttock into the gluteal muscles and descending into the scrotum. (springer.com)
- This case highlights the occurrence of Fournier's gangrene as an extremely rare but life-threatening complication during neoadjuvant radiotherapy for rectal cancer which should be refreshed in the awareness of radiation oncologists and radiologists. (springer.com)
Infection64
- Gas gangrene (also known as clostridial myonecrosis and myonecrosis ) is a bacterial infection that produces gas in tissues in gangrene . (wikipedia.org)
- Gangrene is caused by a critically insufficient blood supply (e.g., peripheral vascular disease) or infection. (wikipedia.org)
- Dry gangrene is the end result of chronic ischemia without infection. (wikipedia.org)
- Because dry gangrene is not accompanied by infection, it is not as emergent as gas gangrene or wet gangrene, both of which have a risk of sepsis. (wikipedia.org)
- Over time, dry gangrene may develop into wet gangrene if an infection develops in the dead tissues. (wikipedia.org)
- Diabetes mellitus is a risk-factor for peripheral vascular disease and thus for dry gangrene, but also a risk factor for wet gangrene, particularly in patients with poorly controlled blood-sugars, as elevated serum glucose creates a favorable environment for bacterial infection. (wikipedia.org)
- Because of the high mortality associated with infected gangrene, an emergency salvage amputation, such as a guillotine amputation, is often needed to limit systemic effects of the infection. (wikipedia.org)
- Gas gangrene is a bacterial infection that produces gas within tissues. (wikipedia.org)
- During the Civil War in the USA nearly half of the soldiers receiving gunshot wounds developed infection with many progressing to gas gangrene. (news-medical.net)
- Gangrene may follow an injury or an infection or may also be a long-term condition that has caused stagnation of blood and slowed down blood circulation. (news-medical.net)
- Wet gangrene is seen after serious injury or frost bite or even a burnt area becomes infected and the infection takes root deep into the tissues. (news-medical.net)
- The infection leads to swelling of the tissues and this blocks the blood supply to the affected area making the infection worse and the gangrene progressive. (news-medical.net)
- When many people hear the term " gangrene ," they may think of toes or fingers being affected by loss of blood flow, infection, or hypothermia , which means the person's body temperature has dropped, and remained, below 95 degrees. (webmd.com)
- Gangrene happens when body tissue is dead or is dying (known as necrosis) because of a lack of blood flow or a bacterial infection . (webmd.com)
- There is also a rarer type, called gas gangrene, which develops from specific bacterial infection deep inside the body and is usually the result of surgery or trauma. (netdoctor.co.uk)
- With dry gangrene, the skin is closed and there is no evidence of infection. (healthline.com)
- It's more of an emergency than dry gangrene because of the possibility of infection spreading to other parts of the body. (healthline.com)
- Wet gangrene can result from the same causes as dry gangrene but always includes infection. (rxlist.com)
- In some cases of wet gangrene, the initial cause is considered to be the infection. (rxlist.com)
- Although many laypeople associate the term gangrene with a bacterial infection, the medical use of the term includes any cause that compromises the blood supply that results in tissue death. (rxlist.com)
- Wet gangrene results from an untreated (or inadequately treated) infection in the body where the local blood supply has been reduced or stopped by tissue swelling, gas production in tissue, bacterial toxins, or all of these factors in combination. (rxlist.com)
- Early stages of wet gangrene may include signs of infection, aching pain with swelling, a reddish skin color or blanched appearance if the area is raised above level of the heart, coolness on the skin surface, ulceration, and a crackly sensation when the skin is pressed due to gas in the tissue. (rxlist.com)
- The stages are similar to wet gangrene (see above), except there is no infection, pus, wetness, or crackly-feeling skin because there is no gas production in the uninfected tissue. (rxlist.com)
- Fournier gangrene is considered a 'flesh-eating' infection," Bersoff-Matcha says. (webmd.com)
- Still, most patients with diabetes have sexual intercourse or may have a urinary tract infection at some point, yet very few ever develop Fournier gangrene," Bersoff-Matcha says. (webmd.com)
- Clostridial gas gangrene is a highly lethal necrotizing soft tissue infection of skeletal muscle caused by toxin- and gas-producing Clostridium species. (medscape.com)
- Another condition that might present with limb ischemia in the setting of patent arterial supply is symmetric peripheral gangrene, a condition in which microvascular occlusion of venules and capillaries occurs in the setting of severe systemic infection and widespread inflammation. (medscape.com)
- Gangrene is the death and decay of tissue that usually occurs when the blood supply to the tissue is cut off by injury or infection. (stlukesonline.org)
- Gangrene is treated by restoring blood flow to the affected area, treating any infection, and removing the dead and dying tissue. (stlukesonline.org)
- Obviously he/she has severe arterial disease that will not resolve and is an infection waiting to happen-- especially if the gangrene is wet. (allnurses.com)
- In children, gangrene is most often caused by a bacterial infection. (drugs.com)
- Wet gangrene typically forms from an infected wound, as the swelling caused by infection may stop the blood flow. (wisegeek.com)
- Most of the symptoms of gangrene of this type are typical of any infection, such as swelling and decay, oozing, an unpleasant odor, and extreme pain at the affected site. (wisegeek.com)
- Infection - gangrene is mainly produced by clostridium perfringens, and other clostridia, bacteria such as streptococcal, staphylococcal may also produce certain forms of gangrene. (hpathy.com)
- Some types of gangrene also involve a bacterial infection. (dailymail.co.uk)
- We suggest that in cases of superficial gangrene of penis without infection the prosthesis may not have to be removed. (biomedsearch.com)
- Other bacteria such as E.coli, Klebsiella , and Proteus may cause infected "wet" gangrene in damaged tissue, resulting in a serious, often life-threatening infection. (medbroadcast.com)
- In contrast, "dry" gangrene occurs when the blood supply to tissue is cut off but no infection develops. (medbroadcast.com)
- Gas gangrene involves a type of necrotizing (flesh-destroying) bacterial infection that a doctor can recognize. (medbroadcast.com)
- This seems to be the first case of IgM-IgG cold agglutinemia occurring during the course of E. coli infection and the third case of fulminant gangrene complicating transient cold agglutinemia. (cmaj.ca)
- Gangrene is the progressive death of body tissue resulting from a lack of blood supply and infection. (doctors-hospital.net)
- Gangrene is caused by infection or a reduced blood supply to tissues. (doctors-hospital.net)
- Gas gangrene is typically an infection of muscle tissue and a characteristic sign of infection is the presence of blisters that bubble with gas near infected areas. (brighthub.com)
- Blood test results show an increase in the number of white blood cells in persons with wet gangrene or infection. (emedicinehealth.com)
- Wet gangrene: Surgical debridement (removal of dead tissue) of the wound is performed, and intravenous antibiotics are administered to control the infection. (emedicinehealth.com)
- A: Gangrene, which refers to tissue death caused by a severe shortage of blood supply or serious bacterial infection, occurs in lower extremities. (medicalxpress.com)
- I understand (basically) that it probably occurs more on the extremities because blood (and hence white blood cells or whatever fights infection) has to travel further to reach there…but…what if someone had an extremely infected wound on their head or neck which turned into gangrene? (straightdope.com)
- (study.com)
- Clostridial myositis and myonecrosis or gas gangrene is an acute, rapidly progressive, non-pyogenic, invasive clostridial infection of the muscles, characterized by profound toxemia, extensive edema, massive death of tissue, and a variable degree of gas production. (uhms.org)
- Gas gangrene is either an endogenous infection, caused by contamination from a clostridial focus in the body, or an exogenous infection, mostly in patients with compound and/or complicated fractures with extensive soft tissue injuries after street accidents. (uhms.org)
- C. histolyticum, C. bifermentans, C. sporogenes, and C. fallax, which augment an infection by their proteolytic capabilities but do not cause the classical gas gangrene syndrome. (uhms.org)
- Gangrene occurs due to reduction in blood supply below critical levels, to a particular tissue or due to infection. (differencebetween.net)
- In infective gangrene, infection starts with contamination of a wound post trauma or after a surgery by the clostridium bacteria. (differencebetween.net)
- OBJECTIVE In diabetic gangrene, concomitant osteopathy and soft-tissue infection often render laboratory and roentgenographic signs unreliable as indicators of osteomyelitis. (diabetesjournals.org)
- Gas gangrene, or myonecrosis, is a form of gangrene and bacterial infection that produces toxins which lead to gas build up inside the tissues. (kenyon.edu)
- Especially common in elderly patients, the gangrene follows from infection of painless abrasions of the feet, normally on the sole. (sciencephoto.com)
- The infection can cause acute local vascular damage, initiating the gangrene, which in turn may become infected. (sciencephoto.com)
- Fournier gangrene is a type of necrotizing infection or gangrene usually affecting the perineum . (healthtap.com)
- My mom has gangrene in her foot and has lost her apatite and is now refusing fluids, is this the infection taking hold? (healthtap.com)
- Dry gangrene develops when the flow of blood to the tissues ceases abruptly and they dry up, provided that a putrescent infection does not occur. (thefreedictionary.com)
- If putrescent infection occurs in the necrotic tissue, the dry gangrene may change into moist gangrene. (thefreedictionary.com)
- The number of reported cases of Fourier gangrene in patients receiving sodium-glucose cotransporter-2 (SGLT2) inhibitors has surged since the US Food and Drug Administration (FDA) issued a 2018 warning about this rare but serious infection, researchers say. (mdedge.com)
- Although the risk for [Fournier gangrene] is low, serious infection should be considered and weighed against the benefits of SGLT2 inhibitor therapy," said Dr. Bersoff-Matcha and co-authors in their recent report published in the Annals of Internal Medicine (2019 May 6. (mdedge.com)
- Fournier gangrene, marked by rapidly progressing necrotizing infection of the genitalia, perineum, and perianal region, requires antibiotics and immediate surgery, according to Dr. Bersoff-Matcha and colleagues. (mdedge.com)
Necrotizing fasciitis6
- Necrotizing fasciitis (Type II) is also called streprtococcal gas gangrene and is caused due to group A streptococci. (news-medical.net)
- Fournier gangrene is a type of necrotizing fasciitis or gangrene affecting the external genitalia and/or perineum. (wikipedia.org)
- How is necrotizing fasciitis (streptococcal gangrene/fasciitis) managed? (medscape.com)
- This condition, which came to be known as Fournier gangrene, is defined as a polymicrobial necrotizing fasciitis of the perineal, perianal, or genital areas (see the image below. (medscape.com)
- Photomicrograph of Fournier gangrene (necrotizing fasciitis), oil immersion at 1000X magnification. (medscape.com)
- Introduction: Perineo-scrotal gangrene is a necrotizing fasciitis concerning soft parts of the genital area which necessitates a rapid, complete and multidisciplinary medical management. (scirp.org)
Risk of gangrene6
- Diabetes further raises the risk of gangrene since gangrene develops as a complication of an open wound or sore. (news-medical.net)
- Some other physical events could increase your risk of gangrene. (healthline.com)
- In August 2018, the FDA required that the risk of gangrene be added to the information patients receive when prescribed the drugs. (webmd.com)
- People who have impaired blood flow, such as people with diabetes, may be at higher risk of gangrene if they have skin wounds and infections that are not treated promptly. (stlukesonline.org)
- The risk of gangrene is higher if the patient has an underlying condition that can damage blood vessels and impede blood flow, such as diabetes or fatty buildup in the arteries. (dailymail.co.uk)
- Diabetes and smoking increase the risk of gangrene by causing narrowing of lumen of blood vessels. (differencebetween.net)
Types of gangrene3
- There may also be excruciating pain in some types of gangrene. (news-medical.net)
- There are two major types of gangrene, wet gangrene and dry gangrene. (rxlist.com)
- There are two major types of gangrene, referred to as dry and wet. (rxlist.com)
Extremities8
- Gangrene is usually external, affecting the extremities, but it can also affect internal tissues. (medicalnewstoday.com)
- Gangrene usually affects your extremities - the areas farthest from your heart, such as your toes and fingers. (healthline.com)
- The most common sites for both wet and dry gangrene to occur are the digits (fingers and toes) and other extremities (hands, arms, feet , and legs). (rxlist.com)
- Trauma - laceration of major artery of extremities or pressure from splinters may cause gangrene. (hpathy.com)
- Gangrene can involve any body part, but the most commonly affected areas are the extremities (feet, arms, legs, hands). (medbroadcast.com)
- Although it usually affects the extremities, gangrene sometimes may involve the internal organs. (thefreedictionary.com)
- Ok, so people get gangrene infections on their extremities, it gets worse if not treated, and one end scenario is that the poor victim gets said extremity amputated. (straightdope.com)
- Dry gangrene is usually localized in the extremities, tip of the nose, and auricles (especially in cases of frostbite or chemical burn). (thefreedictionary.com)
Bacteria22
- This deadly form of gangrene usually is caused by Clostridium perfringens bacteria. (wikipedia.org)
- Wet, or infected, gangrene is characterized by thriving bacteria and has a poor prognosis (compared to dry gangrene) due to sepsis resulting from the free communication between infected fluid and circulatory fluid. (wikipedia.org)
- Deep or crushing injuries sustained in bacteria-rich conditions, such as a battlefield, can lead to gangrene. (medicalnewstoday.com)
- Gas gangrene was a common occurrence until the middle of the 20th century when war injuries were exposed to spores containing the causative bacteria present in soil. (news-medical.net)
- Gangrene may also be caused by special bacteria called Clostridium. (news-medical.net)
- Most cases of Fournier gangrene are infected by both aerobic and anaerobic bacteria. (wikipedia.org)
- wet gangrene - where tissue is infected with bacteria from an injury, causing it to moist (or 'wet') and break down. (netdoctor.co.uk)
- Wet gangrene happens when your body tissues become infected with some type of bacteria. (healthline.com)
- Bacteria called Clostridia cause gas gangrene. (healthline.com)
- All cases of wet gangrene are considered to be infected, almost always by bacteria. (rxlist.com)
- Gas gangrene is a subset of wet gangrene, and is usually caused by the growth of a type of bacteria that only thrives when there is no oxygen. (wisegeek.com)
- The most common symptoms of gangrene caused by this bacteria include swelling, bloody discharge, and extreme pain. (wisegeek.com)
- If clostridia are the cause of the gangrene, the gas produced by the bacteria can be seen bubbling in these pockets. (medbroadcast.com)
- Wet gangrene-Usually occurs when the tissue is infected with bacteria from an injury. (doctors-hospital.net)
- A rare wet type called gas gangrene, develops from specific bacteria deep inside the body. (doctors-hospital.net)
- Gas gangrene is a condition where anaerobic bacteria release toxins that cause tissue death, and if not treated can be fatal. (brighthub.com)
- Gas gangrene is a type of wet gangrene caused by the bacteria known as Clostridia . (emedicinehealth.com)
- gas gangrene occurs in wounds infected by anaerobic bacteria, among which are various species of Clostridium, which break down tissue by gas production and by toxins. (thefreedictionary.com)
- A second type, moist gangrene, results from an invasion of toxin-producing bacteria that destroy tissue. (straightdope.com)
- In gas gangrene, which results from the invasion of wounds by anaerobic bacteria, gas forms under the skin and a watery exudate is produced. (straightdope.com)
- Wet gangrene occurs if bacteria invade this tissue. (vidanthealth.com)
- (study.com)
Clostridium11
- In wet gangrene, the tissue is infected by saprogenic microorganisms (Clostridium perfringens or Bacillus fusiformis, for example), which cause tissue to swell and emit a fetid smell. (wikipedia.org)
- The primary organism causing gas gangrene is Clostridium perfringens. (news-medical.net)
- Other organisms that lead to gangrene in these conditions include Group A Streptococci and Staphylococci, C. histolyticum or other Clostridium spp. (news-medical.net)
- This type of trauma accounts for about 70% of cases of gas gangrene and Clostridium perfringens is found in about 80% of such infections. (news-medical.net)
- [ 1 ] Clostridium perfringens, Clostridium septicum, and Clostridium histolyticum are the principal causes of trauma-associated gas gangrene, and their incidence increases dramatically in times of war, hurricanes, earthquakes, and other mass-casualty conditions. (medscape.com)
- More than 150 Clostridium species have been identified, but only 6 have been demonstrated to be capable of producing the fulminant condition known as clostridial gas gangrene. (medscape.com)
- Clostridium perfringens, previously known as Clostridium welchii, is the most common cause of clostridial gas gangrene (80-90% of cases). (medscape.com)
- At least 20 kinds of Clostridium can cause gas gangrene. (medbroadcast.com)
- Gas gangrene, or clostridial myonecrosis, is usually caused by Clostridium perfringens and may occur spontaneously in association with diabetes mellitus, peripheral vascular disease, or some malignancies but more often after contamination of a deep surgical or traumatic lesion. (asm.org)
- Gas gangrene is caused by a rod shaped, gram positive, spore forming bacterium called Clostridium perfringens . (kenyon.edu)
- The Clostridium perfringens A strain is of the most importance because it causes gas gangrene, or myonecrosis, in humans. (kenyon.edu)
Necrosis12
- Dry gangrene is a form of coagulative necrosis that develops in ischemic tissue, where the blood supply is inadequate to keep tissue viable. (wikipedia.org)
- Gas gangrene can cause necrosis, gas production, and sepsis. (wikipedia.org)
- Are you confused as to what gangrene or necrosis is? (study.com)
- The terms gangrene and necrosis are often confused and some definitions of one actually use the other term in their definition as if they're the same thing! (study.com)
- This lesson is going to first define necrosis, then gangrene and finally compare the two so you're clear as to what they are, how they're related and how they're different. (study.com)
- Technically, necrosis refers to the entire process of irreversible cell death, while gangrene is a term used to refer to tissue death due to some form of interrupted blood supply. (study.com)
- However, unlike gangrene, the term necrosis doesn't automatically imply a problem as a result of inadequate blood supply. (study.com)
- Overall, gangrene can be thought of as just one form of necrosis, but on a larger tissue level. (study.com)
- Gangrene is just one (but not the only) representation of necrosis on a tissue/organ level. (study.com)
- Gangrene is one of the clinical manifestations of necrosis. (differencebetween.net)
- Necrosis pertains to cellular level, whereas gangrene involves the tissues. (differencebetween.net)
- Gangrene is the end result of necrosis. (differencebetween.net)
Bacterial3
- Gas gangrene is caused by bacterial exotoxin-producing clostridial species, which are mostly found in soil, and other anaerobes such as Bacteroides and anaerobic streptococci. (wikipedia.org)
- Gas gangrene is a bacterial problem. (wikipedia.org)
- Treatment of gangrene includes rest and the administration of antibiotics if the gangrene is moist and bacterial invasion is present. (straightdope.com)
Internal gangrene4
- Surgical complications can lead to internal gangrene, with signs of toxic shock. (medicalnewstoday.com)
- This is called internal gangrene and may affect the gall bladder or the intestines trapped within a hernia. (news-medical.net)
- It's also possible to experience internal gangrene, which affects your inner tissues or organs. (healthline.com)
- If your healthcare provider thinks you may have internal gangrene, he or she may order imaging tests or surgery to find out for sure. (vidanthealth.com)
Amputation11
- Photograph before right leg amputation ( hemipelvectomy ) of a patient with gas gangrene . (wikipedia.org)
- Gangrene can lead to amputation. (nih.gov)
- According to estimates from Diabetes UK, those with diabetes are fifteen times more likely to require a major amputation of a limb commonly due to gangrene compared to the general population. (news-medical.net)
- In the UK around 5,000 people with diabetes have an amputation as a result of gangrene annually. (news-medical.net)
- Diabetes-related gangrene is the most common reason for foot amputation. (medbroadcast.com)
- Told he won't live through amputation so he said don't bother but the gangrene in one area is spreading so quickly! (medhelp.org)
- Gas gangrene spreads rapidly and the only effective treatment is surgical excision of the dead tissue, which may sometimes mean limb amputation. (brighthub.com)
- Also see Gangrene and Amputation) This item was posted in the ISN Newsroom. (sclero.org)
- This is second slideshow added to Kathy's story, with photos of gangrene and amputation as a complication of systemic sclerosis (scleroderma). (sclero.org)
- The tip may take a long time to start showing signs of dry gangrene, but the tail should be dealt with, usually by amputation, long before it gets to the point of dying and becoming brittle. (anapsid.org)
- Mother, 66, had gangrene/ partial foot amputation, is not diabetic, had 3 stents in her legs due to poor circulation & heavy smoker. (healthtap.com)
Tissues13
- Gangrene is the death of tissues in your body. (medlineplus.gov)
- However, once gangrene has developed, the affected tissues are not salvageable. (wikipedia.org)
- Because of its ability to quickly spread to surrounding tissues, gas gangrene should be treated as a medical emergency. (wikipedia.org)
- Some kinds of imaging are helpful in diagnosing the spread of gangrene in your internal tissues. (healthline.com)
- For people with poor circulation that results in gangrene, vascular surgery (surgery on the arteries or veins) may be recommended in order to improve the flow of blood through the veins to body tissues. (healthline.com)
- It produces gas over tissues where there is gangrene . (wikipedia.org)
- Severe frostbite (due to overexposure to the cold) can also lead to gangrene due to lack of proper blood flow to the tissues. (medbroadcast.com)
- It can help keep the gangrene from spreading to healthy tissues nearby. (vidanthealth.com)
- Gangrene happens when blood supply to certain tissues is stopped. (vidanthealth.com)
- Gangrene is the death of a mass of cells or tissues due to reduction in blood supply. (differencebetween.net)
- In the early stages, a wound surrounded by redness followed by tissue death with darkened avascular tissue, drainage, air entrapped in the tissues causing a crunching sound with eventual malodorous drainage and red streaks running up the leg followed by fever , sepsis and eventually death may occur in untreated gangrene . (healthtap.com)
- Gangrene results when the entry of oxygen into the tissues ceases or is severely restricted. (thefreedictionary.com)
- Dry gangrene is characterized by the drying up, wrinkling, and compression of tissues (the affected part decreases in size) due to the coagulation of cell proteins and decomposition of formed blood elements. (thefreedictionary.com)
Fournier28
- Initial symptoms of Fournier gangrene include swelling or sudden pain in the scrotum, fever, pallor and generalized weakness. (wikipedia.org)
- Fournier gangrene is usually diagnosed clinically, but laboratory tests and imaging studies are used to confirm diagnosis, determine severity and predict outcomes. (wikipedia.org)
- Fournier gangrene is a urological emergency requiring intravenous antibiotics and debridement (surgical removal) of necrotic (dead) tissue. (wikipedia.org)
- A 2009 epidemiological study found the incidence of Fournier gangrene to be 1.6 cases per 100,000 males, in the United States. (wikipedia.org)
- Puerto Rican abolitionist and pro-independence leader Segundo Ruiz Belvis died from Fournier gangrene in November 1867. (wikipedia.org)
- Fournier gangrene and Jean Alfred Fournier at Who Named It? (wikipedia.org)
- From March 2013, until Jan. 31, 2019, the FDA found 55 cases of this condition, known as Fournier gangrene, in people taking three different types of the SGLT2 inhibitors. (webmd.com)
- So, she says, even for people who have something that makes the disease more likely and a triggering event, Fournier gangrene remains rare. (webmd.com)
- For instance, previous research has said about 1.6 men in every 100,000 will get Fournier gangrene, and among men 50 to 79, about 3 in every 100,000 will get it. (webmd.com)
- So, they reason, if the Fournier gangrene were linked only with diabetes and not the specific drug, they would expect to find far more than 19 cases with the other types of drugs. (webmd.com)
- Fournier gangrene was first identified in 1883, when the French venereologist Jean Alfred Fournier described a series in which 5 previously healthy young men suffered from a rapidly progressive gangrene of the penis and scrotum without apparent cause. (medscape.com)
- Impaired immunity (eg, from diabetes) is known to increase susceptibility to Fournier gangrene. (medscape.com)
- However, the disease was named after Jean-Alfred Fournier, a Parisian venereologist, on the basis of a transcript from an 1883 clinical lecture in which Fournier presented a case of perineal gangrene in an otherwise healthy young man, adding this to a compiled series of 4 additional cases. (medscape.com)
- In anecdotes, Fournier described recognized causes of perineal gangrene, including placement of a mistress' ring around the phallus, ligation of the prepuce (used in an attempt to control enuresis or as an attempted birth control technique practiced by an adulterous man to avoid impregnating his married lover), placement of foreign bodies such as beans within the urethra, and excessive intercourse in diabetic and alcoholic persons. (medscape.com)
- The complex anatomy of the male external genitalia influences the initiation and progression of Fournier gangrene. (medscape.com)
- Therefore, a working knowledge of the anatomy of the male lower urinary tract and external genitalia is critical for the clinician treating a patient with Fournier gangrene. (medscape.com)
- Because Fournier gangrene is predominately an infectious process of the superficial and deep fascial planes, understanding the anatomic relationship of the skin and subcutaneous structures of the perineum and abdominal wall is important. (medscape.com)
- Two patients in septic shock due to Fournier gangrene were admitted to the Intensive Care Unit of Emergency Department. (hindawi.com)
- Fournièr's gangrene was primarily described by the French dermatologist Jean Alfred Fournier in 1883. (prolekare.cz)
- Will occur fournier gangrene in the foot? (healthtap.com)
- Health care providers prescribing SGLT2 inhibitors to patients with diabetes should have a high index of suspicion for the signs and symptoms of Fournier gangrene, given its substantial morbidity and mortality, according to Susan J. Bersoff-Matcha, MD, and her colleagues at the FDA. (mdedge.com)
- In the previous warning , FDA officials said 12 cases of Fournier gangrene in patients taking an SGLT2 inhibitor had been reported to the agency or in medical literature from March 2013, when the first such inhibitor was approved, and May 2018. (mdedge.com)
- In this latest report, a total of 55 Fournier gangrene cases had been reported in patients receiving SGLT2 inhibitors from March 2, 2013 through January 31, 2019. (mdedge.com)
- The researchers also noted that diabetes is a comorbidity in 32% to 66% of cases of Fournier gangrene. (mdedge.com)
- But the likliehood that diabetes mellitus alone causes Fournier gangrene seems unlikley, given that Dr. Bersoff-Matcha and co-authors only found 19 Fournier gangrene cases associated with other classes of antiglycemic agents reported to the FDA or in the literature over a 35-year time frame. (mdedge.com)
- If Fournier gangrene were associated only with diabetes mellitus and not SGLT2 inhibitors, we would expect far more cases reported with the other antiglycemic agents, considering the 35-year timeframe and the large number of agents," they said in their report. (mdedge.com)
- Serious complications and death are likely if Fournier gangrene is not recognized immediately and surgical intervention is not carried out within the first few hours of diagnosis," they said in the report. (mdedge.com)
- The incidence of Fournier gangrene in patients taking SGLT2 inhibitors can't be established by these cases reported to the FDA, which are spontaneously provided by health care providers and patients, investigators said. (mdedge.com)
20181
- 2018. https://www.unboundmedicine.com/icd/view/ICD-10-CM/876926/all/I96___Gangrene__not_elsewhere_classified. (unboundmedicine.com)
Sepsis6
- Gas gangrene can cause myonecrosis (muscle tissue death), gas production, and sepsis . (wikipedia.org)
- (rxlist.com)
- Dry gangrene, if it does not become infected and progress to wet gangrene, usually does not cause sepsis or cause the patient to die. (rxlist.com)
- If the gangrene is widespread, sepsis can occur. (doctors-hospital.net)
- An autopsy revealed the disabled Millington girl died from sepsis from gangrene. (timesfreepress.com)
- Reportedly, sepsis from the gangrene killed her. (cafemom.com)
Wounds5
- If ischemia is detected early, when ischemic wounds rather than gangrene are present, the process can be treated by revascularization (via vascular bypass or angioplasty). (wikipedia.org)
- Louis Pasteur first observed garlic's antibacterial qualities in 1858, and until World War II is was routinely used to prevent gangrene in patients with infected wounds. (yourdictionary.com)
- Gas gangrene rose to prominence during World War I. The incidence amongst civilians was low but gas gangrene complicated 6% of open fractures and 1% of open wounds in military personal. (brighthub.com)
- gas gangrene a condition often resulting from dirty, lacerated wounds in which the muscles and subcutaneous tissue become filled with gas and a serosanguineous exudate. (thefreedictionary.com)
- Internal causes include states and processes that interfere with tissue nutrition, mainly injuries to blood vessels-wounds, arterial occlusions, and constriction of blood vessels by spasms or anatomical changes, such as those occurring in atherosclerosis, which often causes infarcts, thrombosis, and senile gangrene. (thefreedictionary.com)
Diagnosis4
- The diagnosis of gangrene is based on symptoms and supported by tests such as medical imaging. (wikipedia.org)
- The early diagnosis of gas gangrene is paramount, as delay in aggressive combined treatment may result in death. (nih.gov)
- The diagnosis of gangrene is based on history, physical examination, blood tests, and other exams. (emedicinehealth.com)
- For clostridial myositis and myonecrosis (gas gangrene) or spreading clostridial cellulitis with systemic toxicity (or a presumptive diagnosis of either) the preferred treatment is a combination of hyperbaric oxygen (HBO2), surgery, and antibiotics. (uhms.org)
Diabetes mellitus1
- Type 1 and type 2 diabetes mellitus leads to dry gangrene due to the high blood sugar and the damage the diabetes causes to the blood vessels that take blood to the fingers and toes. (news-medical.net)
Develop gangrene2
- This treatment is especially effective in people who develop gangrene from diabetic foot ulcers. (vidanthealth.com)
- Why do Diabetic patients develop gangrene in foot? (healthtap.com)
Occurs12
- Gangrene occurs when a lack of blood supply, and therefore oxygen, results in tissue death. (medicalnewstoday.com)
- Gangrene is a type of tissue death which occurs due to loss of blood supply. (news-medical.net)
- Dry gangrene occurs when there is slowing or obstruction in blood flow to parts of the body like toes and fingers. (news-medical.net)
- Dry gangrene occurs when one of your body parts isn't getting enough oxygen. (healthline.com)
- Infrequently, dry gangrene can occur quickly, over a few hours to days, when a rapid arterial blockage occurs (for example, an arterial blood clot suddenly occludes a small artery to a toe). (rxlist.com)
- By the fourth to fifth day, frank gangrene is present, and extensive sloughing of skin occurs. (medscape.com)
- Strangulation occurs in about 25 percent of bowel obstruction cases and is a serious condition that can progress to gangrene within six to 12 hours. (yourdictionary.com)
- Gangrene usually occurs when the blood supply to the affected areas is cut off. (home-remedies-for-you.com)
- Gangrene often occurs when the blood supply to part of the body has been cut off, resulting in death of the tissue. (wisegeek.com)
- Gas gangrene usually occurs at an injury site or at the site of a recent surgical wound. (brighthub.com)
- Dry gangrene occurs gradually and results from slow reduction of the blood flow in the arteries. (thefreedictionary.com)
- Wet gangrene occurs due to venous blockages. (differencebetween.net)
Body tissue6
- Gangrene is when part of your body tissue dies. (healthline.com)
- Gangrene refers to dead or dying body tissue(s) that occur because of inadequate blood supply. (rxlist.com)
- Gangrene is a term that describes dead or dying body tissue(s) that occur because the local blood supply to the tissue is either lost or is inadequate to keep the tissue alive. (rxlist.com)
- Gangrene is defines as death of a body tissue which is caused due to loss of blood supply or inadequate blood supply to the tissue. (hpathy.com)
- http://www.encyclopedia.com/articles/04905.html gangrene, local death of body tissue. (straightdope.com)
- Gangrene is the death of body tissue and usually seen in elderly people or diabetic people. (kenyon.edu)
Moist6
- In wet or moist gangrene, the skin swells and blisters form and may rupture. (medicalnewstoday.com)
- Wet or moist gangrene develops as a complication of an untreated infected wound . (emedicinehealth.com)
- The three major types are moist, dry, and gas gangrene. (thefreedictionary.com)
- Moist gangrene is caused by sudden stoppage of blood, resulting from burning by heat or acid, severe freezing, physical accident that destroys the tissue, a tourniquet that has been left on too long, or a clot or other embolism. (thefreedictionary.com)
- At first, tissue affected by moist gangrene has the color of a bad bruise, is swollen, and often blistered. (thefreedictionary.com)
- There are also moist and dry gangrenes and gas gangrene. (thefreedictionary.com)
Tissue death5
- Gangrene is a type of tissue death caused by not enough blood supply. (wikipedia.org)
- Gangrene is caused due to tissue death that results from stoppage of blood supply to the affected organ. (news-medical.net)
- Gangrene has been recognized as a localized area of tissue death since ancient times. (rxlist.com)
- Twisting of any portion of the intestines may cut off the supply of blood to a loop of bowel (strangulation), reducing the flow of oxygen to bowel tissue (ischemia) and leading to tissue death ( gangrene ). (yourdictionary.com)
- If you have symptoms of gangrene, your healthcare team will give you a physical exam to check for signs of tissue death. (vidanthealth.com)
Toes6
- Similarly, peripheral artery disease leads to fatty deposits in the arteries and stops blood from flowing to the fingers and toes leading to gangrene. (news-medical.net)
- Gangrene may affect small areas, such as fingers or toes that have been frostbitten, or larger areas of tissue, such as part of the foot. (stlukesonline.org)
- Fulminant gangrene of the fingers, toes and nose developed in a 57-year-old woman with Escherichia coli pneumonia. (cmaj.ca)
- A champion bagpipe player had to have all his fingers and toes amputated after he developed gangrene which nearly killed him. (sclero.org)
- I developed severe dry gangrene on right foot after trauma, 4 toes already amputated, but it is spreading very slow. (healthtap.com)
- I have lots of dry gangrene on right foot, lost 4 toes, but it doesn't go past the mid-foot. (healthtap.com)
Complications4
- Complications depend on where in the body the gangrene is, how much gangrene there is, the cause of the gangrene, and the person's overall condition. (medlineplus.gov)
- Wet gangrene can spread much quicker leading to life-threatening complications like septic shock if not treated immediately. (news-medical.net)
- People with diabetes and peripheral artery disease are especially vulnerable to complications such as gangrene, because, in addition to poor blood circulation , they often have decreased sensation in their feet due to nerve damage. (medicalxpress.com)
- What are the complications of gangrene? (vidanthealth.com)
Occur9
- This type of gangrene can occur in people with diabetes who have an injury but do not notice or attend to it due to diabetic neuropathy. (medicalnewstoday.com)
- If the gangrene is widespread, then septicaemia and septic shock can occur. (netdoctor.co.uk)
- I don't really know much about gangrene, just that it can occur from someone sleeping on their arm and cutting off circulation! (metafilter.com)
- gangrene may occur in that section of tissue. (thefreedictionary.com)
- In acute appendicitis , areas of gangrene may occur in the walls of the appendix with consequent rupture through a gangrenous area. (thefreedictionary.com)
- Gangrene usually affects an arm or leg, but it may occur anywhere, e.g., pulmonary gangrene may follow an abscess of the lung. (straightdope.com)
- The alpha toxin, also known as CPA or PLC, is a crucial virulence factor for this bacterium because gas gangrene cannot occur without it. (kenyon.edu)
- Venous limb gangrene (VLG) can occur in cancer patients, but the clinical picture and pathogenesis remain uncertain. (bloodjournal.org)
- Gangrene may occur without microbial action (aseptic gangrene) and with microbial involvement (septic, or putrefactive, gangrene). (thefreedictionary.com)
Arteries7
- Arteriosclerosis leads to thickened walls of the arteries or formation of cholesterol plaques and narrowing of the diameter of the small vessels leading to gangrene. (news-medical.net)
- Most cases of dry gangrene result from insufficient blood flowing through the arteries, usually due to diabetes, high cholesterol , or smoking. (wisegeek.com)
- Vascular - gangrene is seen is vascular diseases such as peripheral arteriosclerosis, thrombosis of the large arteries, thrombosis of terminal aorta etc. (hpathy.com)
- Dry gangrene is caused by a reduction of blood flow through the arteries. (emedicinehealth.com)
- Dry gangrene is commonly seen in people with blockage of arteries ( arteriosclerosis ) resulting from increased cholesterol levels , diabetes , cigarette smoking , and genetic and other factors. (emedicinehealth.com)
- Gangrene tends to happen more often among people with peripheral artery disease , a common circulatory problem in which narrowed arteries reduce blood flow to the limbs. (medicalxpress.com)
- It is characterized by obliterative endarteritis and thrombosis of the subcutaneous arteries resulting in gangrene of the subcutaneous tissue and overlying skin. (hindawi.com)
Form of gangrene2
- Gas ("wet") gangrene is the most life-threatening form of gangrene. (medbroadcast.com)
- This form of gangrene spreads very quickly, and can cause a rapid death. (medbroadcast.com)
Signs of gangrene3
- Physical examination of the affected area is performed to look for signs of gangrene. (emedicinehealth.com)
- What are the signs of gangrene, and how can it be avoided? (medicalxpress.com)
- A 40 year old male came to the emergency room of the homeopathic hospital complaining of severe, agonizing pain in his right foot with signs of gangrene , cellulites and toxemia. (hpathy.com)
Antibiotics3
- The typical treatment of wet gangrene is removal of the dead tissue, as well as antibiotics given intravenously. (wisegeek.com)
- Treatments for gangrene include surgery to remove dead tissue, antibiotics and other approaches. (dailymail.co.uk)
- Gangrene often spreads so quickly that it can't be stopped by antibiotics alone. (medbroadcast.com)
Trauma3
- Dry gangrene can result from conditions that reduce or block arterial blood flow such as diabetes , arteriosclerosis , and tobacco addiction as well as from trauma , frostbite , or injury. (rxlist.com)
- [ 6 ] He differentiated these cases from perineal gangrene associated with diabetes, alcoholism, or known urogenital trauma, although these are currently recognized risk factors for the perineal gangrene now associated with his name. (medscape.com)
- Gas gangrene can be a result of surgery or trauma. (doctors-hospital.net)
Myonecrosis1
- Gas gangrene, also called clostridial myonecrosis, is a particularly virulent form of wet gangrene. (medicalnewstoday.com)
Complication1
- Penile gangrene: a complication of penile prosthesis. (biomedsearch.com)
Vascular3
- Usually, the progression of dry gangrene is much slower (days to months) than wet gangrene because the vascular compromise slowly develops due to the progression of diseases that can result in local arterial blockage over time. (rxlist.com)
- For example, peripheral vascular disease in which blood flow to the legs is poor can deprive a foot or leg of blood or oxygen, resulting in gangrene. (medbroadcast.com)
- The vascular surgeon told my mother she has early stages of gangrene in her foot. (healthtap.com)
Treatment16
- Gangrene requires urgent evaluation and treatment. (medlineplus.gov)
- If treatment is delayed, the gangrene is extensive, or the person has other significant medical problems, the person may die. (medlineplus.gov)
- Wet gangrene needs immediate treatment, as it can spread quickly and be fatal. (medicalnewstoday.com)
- Gas gangrene has become uncommon in modern warfare due to better surgical management and treatment. (news-medical.net)
- What is the treatment of gangrene? (netdoctor.co.uk)
- The treatment for gangrene should only be undertaken by an experienced health care professional. (home-remedies-for-you.com)
- Home remedies for the treatment of gangrene using herbal products should only be attempted after consulting your doctor. (home-remedies-for-you.com)
- Oguzkurt L, Ozkan U, Demirturk OS, Gur S. Endovascular treatment of phlegmasia cerulea dolens with impending venous gangrene: manual aspiration thrombectomy as the first-line thrombus removal method. (medscape.com)
- Gangrene is a life-threatening condition that needs immediate treatment. (drugs.com)
- Dry gangrene usually progresses slowly, so knowing the symptoms of gangrene of this type can help patients get treatment as soon as possible. (wisegeek.com)
- Gas gangrene needs to be treated quickly before the toxins cause damage to the internal organs, and the treatment is typically the same as the methods used for general wet gangrene. (wisegeek.com)
- This article discusses the homeopathy treatment of Gangrene along with the best homeopathic medicine for Gangrene treatment. (hpathy.com)
- People with gangrene require urgent assessment and treatment to prevent the spread of gangrene. (emedicinehealth.com)
- without treatment, gas gangrene is invariably fatal. (straightdope.com)
- The earlier gangrene is treated, the more successful the treatment is likely to be. (vidanthealth.com)
- 3. Treatment of Fournièr's gangrene Tab. (prolekare.cz)
Severe5
- Wet gangrene can develop following a severe burn or frostbite . (medicalnewstoday.com)
- If it is severe, gangrene sometimes requires that a part of the body, such as a finger, toe, or foot, be amputated. (stlukesonline.org)
- In severe cases of cholecystitis , which is usually associated with gallstones , gangrene may develop where the stones compress the mucous membrane. (thefreedictionary.com)
- Severe cases of gangrene may lead to organ failure and even death. (vidanthealth.com)
- We conclude that venous limb ischemia/gangrene is explained in some cancer patients by profoundly disturbed procoagulant-anticoagulant balance, whereby warfarin fails to block cancer-associated hypercoagulability while nonetheless contributing to severe PC depletion, manifest as a characteristic supratherapeutic INR caused by parallel severe factor VII depletion. (bloodjournal.org)
Fever2
- If the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. (medlineplus.gov)
- There is also a certain type of wet gangrene, called gas gangrene , in which an infected wound is swollen, painful, and produces bloody discharge, often resulting in a fever and irregular heartbeat. (wisegeek.com)
Penis3
- A man's entire penis fell off after it rotted away because of gangrene triggered during surgery to treat cancer in his neck. (dailymail.co.uk)
- The gangrene had spread along the penis shaft and, although surgeons tried to cut away the infected flesh to save the man's penis, it eventually became so destroyed it dropped off. (dailymail.co.uk)
- A case of superficial gangrene of penis after insertion of a malleable penile prosthesis is presented. (biomedsearch.com)
Develops2
- Wet gangrene often develops as a result of a traumatic injury like an automobile accident, gunshot wound, burns or wound due to a sharp instrument. (news-medical.net)
- Sometimes the first sign of dry gangrene is a reddish line that develops around the affected tissue. (healthline.com)
20191
Cases of gas gangrene1
- About 1,000 cases of gas gangrene are reported yearly in the United States. (wikipedia.org)
Common symptoms of gangrene1
- The common symptoms of gangrene include change of color of the affected area. (news-medical.net)
Diseases6
- Blood vessel diseases such as atherosclerosis commonly cause dry gangrene. (medicalnewstoday.com)
- Dry gangrene can result from any of a number of diseases or mechanisms that can reduce or block arterial blood flow. (rxlist.com)
- Although the most common diseases that can cause dry gangrene are diabetes , arteriosclerosis, and tobacco addiction, there are many other lesser-known diseases that can lead to this problem. (rxlist.com)
- For example, some autoimmune diseases that attack blood vessels ( vasculitis syndromes) may result in enough damage to cause dry gangrene. (rxlist.com)
- Autoimmune diseases such as lupus erythematosus, sclerederma and rheumatoid arthritis may be associated with Raynaud phenomenon and gangrene. (hpathy.com)
- This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Gangrene. (rightdiagnosis.com)
Hernia2
- ICD-9 code 550.03 for Recurrent bilateral inguinal hernia with gangrene is a medical classification as listed by WHO under the range -HERNIA OF ABDOMINAL CAVITY (550-553). (aapc.com)
- ICD-9 code 550.92 for Bilateral inguinal hernia without obstruction or gangrene is a medical classification as listed by WHO under the range -HERNIA OF ABDOMINAL CAVITY (550-553). (aapc.com)
Symmetric peripheral gangrene1
- What are the signs and symptoms of symmetric peripheral gangrene? (medscape.com)
Rapidly3
- In 1764, Baurienne originally described an idiopathic, rapidly progressive soft-tissue necrotizing process that led to gangrene of the male genitalia. (medscape.com)
- At the time of arrival in the ER, the patient had reached a toxic stage of the snake bite and there was a possibility of incipient septecaemia in addition to the rapidly extending cellulitis, and local gangrene that had already developed. (hpathy.com)
- Because gangrene can spread rapidly over a large area of the body, the amount of dead tissue can be quite large. (vidanthealth.com)
Artery5
- Dry gangrene is often due to peripheral artery disease, but can be due to acute limb ischemia. (wikipedia.org)
- In people with dry gangrene, an arteriogram may be performed to visualize any obstruction in the artery which supplies blood to the affected part. (emedicinehealth.com)
- Thrombosis of the mesenteric artery may result in gangrene. (thefreedictionary.com)
- People whose gangrene is a result of a blocked artery, for example, may have bypass surgery or an angioplasty to fix the problem. (vidanthealth.com)
- Untreated gangrene in patients with peripheral artery disease. (ahajournals.org)
Morbidity and morta1
- Gas gangrene continues to cause significant morbidity and mortality. (nih.gov)
Death14
- Gangrene is the death of tissue in part of the body. (medlineplus.gov)
- Gangrene refers to the death and rotting of skin tissue and skin cells. (medicalnewstoday.com)
- Gangrene is a medical emergency that could lead to amputations or death. (healthline.com)
- BALTIMORE - King Herod, the bloodthirsty Judean ruler who reputedly tried to kill the infant Jesus, died an excruciating death, brought on by kidney disease and finished off by gangrene, a medical sleuth said. (latimes.com)
- If malrotation or duodenal volvulus has caused the blood supply to be cut off in a portion of the intestine before surgery, death of intestinal tissue can result and life-threatening gangrene can develop. (yourdictionary.com)
- Gangrene is term used to describe the death of tissue in any part of the body. (home-remedies-for-you.com)
- This is because of the dangers associated with gangrene which can often lead to a loss of a limb and even death. (home-remedies-for-you.com)
- Several medications (see box ) are CYP 3A4 inhibitors and slow the metabolism of ergotamine, causing serious toxic effects, including stroke, gangrene and death. (cmaj.ca)
- Gangrene refers to the decay and death of tissue resulting from an interruption of blood flow to a certain area of your body. (dailymail.co.uk)
- Gangrene is the death of tissue in your body. (medbroadcast.com)
- Seeing someone affected with gangrene in your dream, foretells of grief, loss and possible death of someone near. (hyperdictionary.com)
- Gangrene is a medical term used to describe the death of an area of the body. (emedicinehealth.com)
- Gangrene is a term that refers, in simple terms, to the death of a tissue or organ as a result of an inadequate blood supply. (study.com)
- Gangrene is the death of a part of or all of a tissue or organ as a result of an inadequate supply of blood. (study.com)
Wound4
- Traumatic gas gangrene is caused after a deep, penetrating injury like a knife or a gunshot wound or a car crash. (news-medical.net)
- To prevent gangrene in an open wound, the wound should be kept as clean as possible. (thefreedictionary.com)
- I'm not a doctor, but my understanding is that gangrene means that dead flesh in a wound is rotting. (straightdope.com)
- Need advice on chicken wound care, possible gangrene. (backyardchickens.com)