Gangrene: Death and putrefaction of tissue usually due to a loss of blood supply.Gas Gangrene: A severe condition resulting from bacteria invading healthy muscle from adjacent traumatized muscle or soft tissue. The infection originates in a wound contaminated with bacteria of the genus CLOSTRIDIUM. C. perfringens accounts for the majority of cases (over eighty percent), while C. noyvi, C. septicum, and C. histolyticum cause most of the other cases.Penile Diseases: Pathological processes involving the PENIS or its component tissues.Toes: Any one of five terminal digits of the vertebrate FOOT.Amputation: The removal of a limb or other appendage or outgrowth of the body. (Dorland, 28th ed)Clostridium perfringens: The most common etiologic agent of GAS GANGRENE. It is differentiable into several distinct types based on the distribution of twelve different toxins.Scrotum: A cutaneous pouch of skin containing the testicles and spermatic cords.Debridement: The removal of foreign material and devitalized or contaminated tissue from or adjacent to a traumatic or infected lesion until surrounding healthy tissue is exposed. (Dorland, 27th ed)Clostridium septicum: A species of gram-positive bacteria in the family Clostridiaceae. Infections have a strong association with malignancies and also with GAS GANGRENE.Fasciitis: Inflammation of the fascia. There are three major types: 1, Eosinophilic fasciitis, an inflammatory reaction with eosinophilia, producing hard thickened skin with an orange-peel configuration suggestive of scleroderma and considered by some a variant of scleroderma; 2, Necrotizing fasciitis (FASCIITIS, NECROTIZING), a serious fulminating infection (usually by a beta hemolytic streptococcus) causing extensive necrosis of superficial fascia; 3, Nodular/Pseudosarcomatous /Proliferative fasciitis, characterized by a rapid growth of fibroblasts with mononuclear inflammatory cells and proliferating capillaries in soft tissue, often the forearm; it is not malignant but is sometimes mistaken for fibrosarcoma.Ischemia: A hypoperfusion of the BLOOD through an organ or tissue caused by a PATHOLOGIC CONSTRICTION or obstruction of its BLOOD VESSELS, or an absence of BLOOD CIRCULATION.Foot Ulcer: Lesion on the surface of the skin of the foot, usually accompanied by inflammation. The lesion may become infected or necrotic and is frequently associated with diabetes or leprosy.Calciphylaxis: Condition of induced systemic hypersensitivity in which tissues respond to appropriate challenging agents with a sudden local calcification.Leg: The inferior part of the lower extremity between the KNEE and the ANKLE.Genital Diseases, Male: Pathological processes involving the male reproductive tract (GENITALIA, MALE).Noma: A severe gangrenous process occurring predominantly in debilitated and malnourished children, especially in underdeveloped countries. It typically begins as a small vesicle or ulcer on the gingiva that rapidly becomes necrotic and spreads to produce extensive destruction of the buccal and labial mucosa and tissues of the face, which may result in severe disfigurement and even death. Various bacteria have been implicated in the etiology. (Dorland, 27th ed)Fingers: Four or five slender jointed digits in humans and primates, attached to each HAND.Toe Phalanges: Bones that make up the SKELETON of the TOES, consisting of two for the great toe, and three for each of the other toes.Lower Extremity: The region of the lower limb in animals, extending from the gluteal region to the FOOT, and including the BUTTOCKS; HIP; and LEG.Bromhexine: A mucolytic agent used in the treatment of respiratory disorders associated with viscid or excessive mucus. (From Martindale, The Extra Pharmacopoeia, 30th ed, p744)Skin UlcerArterial Occlusive Diseases: Pathological processes which result in the partial or complete obstruction of ARTERIES. They are characterized by greatly reduced or absence of blood flow through these vessels. They are also known as arterial insufficiency.Tibial Arteries: The anterior and posterior arteries created at the bifurcation of the popliteal artery. The anterior tibial artery begins at the lower border of the popliteus muscle and lies along the tibia at the distal part of the leg to surface superficially anterior to the ankle joint. Its branches are distributed throughout the leg, ankle, and foot. The posterior tibial artery begins at the lower border of the popliteus muscle, lies behind the tibia in the lower part of its course, and is found situated between the medial malleolus and the medial process of the calcaneal tuberosity. Its branches are distributed throughout the leg and foot.Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Streptococcus pyogenes: A species of gram-positive, coccoid bacteria isolated from skin lesions, blood, inflammatory exudates, and the upper respiratory tract of humans. It is a group A hemolytic Streptococcus that can cause SCARLET FEVER and RHEUMATIC FEVER.Staphylococcus aureus: Potentially pathogenic bacteria found in nasal membranes, skin, hair follicles, and perineum of warm-blooded animals. They may cause a wide range of infections and intoxications.MedlinePlus: NATIONAL LIBRARY OF MEDICINE service for health professionals and consumers. It links extensive information from the National Institutes of Health and other reviewed sources of information on specific diseases and conditions.Electronic Mail: Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.Food Dispensers, Automatic: Mechanical food dispensing machines.Editorial Policies: The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.Authorship: The profession of writing. Also the identity of the writer as the creator of a literary production.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Postal Service: The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.Internet: A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.Neuroendocrinology: The study of the anatomical and functional relationships between the nervous system and the endocrine system.Digestive System Diseases: Diseases in any part of the GASTROINTESTINAL TRACT or the accessory organs (LIVER; BILIARY TRACT; PANCREAS).Information Centers: Facilities for collecting and organizing information. They may be specialized by subject field, type of source material, persons served, location, or type of services.Vocabulary, Controlled: A specified list of terms with a fixed and unalterable meaning, and from which a selection is made when CATALOGING; ABSTRACTING AND INDEXING; or searching BOOKS; JOURNALS AS TOPIC; and other documents. The control is intended to avoid the scattering of related subjects under different headings (SUBJECT HEADINGS). The list may be altered or extended only by the publisher or issuing agency. (From Harrod's Librarians' Glossary, 7th ed, p163)Terminology as Topic: The terms, expressions, designations, or symbols used in a particular science, discipline, or specialized subject area.Subject Headings: Terms or expressions which provide the major means of access by subject to the bibliographic unit.Dictionaries as Topic: Lists of words, usually in alphabetical order, giving information about form, pronunciation, etymology, grammar, and meaning.Fat Body: A nutritional reservoir of fatty tissue found mainly in insects and amphibians.Clostridium Infections: Infections with bacteria of the genus CLOSTRIDIUM.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Clostridium difficile: A common inhabitant of the colon flora in human infants and sometimes in adults. It produces a toxin that causes pseudomembranous enterocolitis (ENTEROCOLITIS, PSEUDOMEMBRANOUS) in patients receiving antibiotic therapy.Dictionaries, MedicalDictionaries, ChemicalPhonetics: The science or study of speech sounds and their production, transmission, and reception, and their analysis, classification, and transcription. (Random House Unabridged Dictionary, 2d ed)Language: A verbal or nonverbal means of communicating ideas or feelings.Soft Tissue Infections: Infections of non-skeletal tissue, i.e., exclusive of bone, ligaments, cartilage, and fibrous tissue. The concept is usually referred to as skin and soft tissue infections and usually subcutaneous and muscle tissue are involved. The predisposing factors in anaerobic infections are trauma, ischemia, and surgery. The organisms often derive from the fecal or oral flora, particularly in wounds associated with intestinal surgery, decubitus ulcer, and human bites. (From Cecil Textbook of Medicine, 19th ed, p1688)Fasciitis, Necrotizing: A fulminating bacterial infection of the deep layers of the skin and FASCIA. It can be caused by many different organisms, with STREPTOCOCCUS PYOGENES being the most common.Fournier Gangrene: An acute necrotic infection of the SCROTUM; PENIS; or PERINEUM. It is characterized by scrotum pain and redness with rapid progression to gangrene and sloughing of tissue. Fournier gangrene is usually secondary to perirectal or periurethral infections associated with local trauma, operative procedures, or urinary tract disease.

Gangrenous cystitis: a rare cause of colovesical fistula. (1/271)

A case of gangrenous cystitis presenting as a colovesical fistula in an elderly woman is described. The literature on this rare condition is reviewed.  (+info)

Traditional bone setter's gangrene. (2/271)

Traditional bone setter's gangrene (TBSG) is the term we use to describe the sequelae sometimes seen after treatment with native fracture splints. Twenty five consecutive complications were recorded in 25 patients aged between 5-50 years with a median age of 10 years. The major complication of the native fracture splint treatment was distal limb gangrene necessitating proximal amputations in 15 cases.  (+info)

Thigh isosulfan blue injection in the treatment of postoperative lymphatic complications. (3/271)

Postoperative lymphatic complications after infrainguinal revascularization are troublesome and potentially serious complications. Vital dye injection into the web spaces of the foot has been recommended as a simple and reliable method to identify lymphatic channel disruption before groin exploration. Such distal injections, however, are not always successful. We describe a modified technique using a proximal thigh injection with isosulfan blue, which is faster and more useful than the distal web space method.  (+info)

Efficacy of dorsal pedal artery bypass in limb salvage for ischemic heel ulcers. (4/271)

PURPOSE: Although pedal artery bypass has been established as an effective and durable limb salvage procedure, the utility of these bypass grafts in limb salvage, specifically for the difficult problem of heel ulceration, remains undefined. METHODS: We retrospectively reviewed 432 pedal bypass grafts placed for indications of ischemic gangrene or ulceration isolated to either the forefoot (n = 336) or heel (n = 96). Lesion-healing rates and life-table analysis of survival, patency, and limb salvage were compared for forefoot versus heel lesions. Preoperative angiograms were reviewed to evaluate the influence of an intact pedal arch on heel lesion healing. RESULTS: Complete healing rates for forefoot and heel lesions were similar (90.5% vs 86.5%, P =.26), with comparable rates of major lower extremity amputation (9.8% vs 9.3%, P =.87). Time to complete healing in the heel lesion group ranged from 13 to 716 days, with a mean of 139 days. Preoperative angiography demonstrated an intact pedal arch in 48.8% of the patients with heel lesions. Healing and graft patency rates in these patients with heel lesions were independent of the presence of an intact arch, with healing rates of 90.2% and 83.7% (P =.38) and 2-year patency rates of 73.4% and 67.0% in complete and incomplete pedal arches, respectively. Comparison of 5-year primary and secondary patency rates between the forefoot and heel lesion groups were essentially identical, with primary rates of 56.9% versus 62.1% (P =.57) and secondary rates of 67.2% versus 60.3% (P =.50), respectively. CONCLUSION: Bypass grafts to the dorsalis pedis artery provide substantial perfusion to the posterior foot such that the resulting limb salvage and healing rates for revascularized heel lesions is excellent and comparable with those observed for ischemic forefoot pathology.  (+info)

Nontraumatic lower extremity amputations in the Medicare end-stage renal disease population. (5/271)

BACKGROUND: Nontraumatic lower limb amputation is a serious complication of both diabetic neuropathy and peripheral vascular disease. Many people with end-stage renal disease (ESRD) suffer from advanced progression of these diseases. This study presents descriptive information on the rate of lower limb amputation among people with ESRD who are covered by the Medicare program. METHODS: Using hospital bill data for the years 1991 through 1994 from the Health Care Financing Administration's ESRD program management and medical information system (PMMIS), amputations were based on ICD9 coding. These hospitalizations were then linked back to the PMMIS enrollment database for calculation of rates. RESULTS: The rate of lower limb amputation increased during the four-year period from 4.8 per 100 person years in 1991 to 6.2 in 1994. Among persons whose renal failure was attributed to diabetic nephropathy, the rates in 1991 and 1994 were 11.8 and 13.8, respectively. The rate among diabetic persons with ESRD was 10 times as great as among the diabetic population at large. Two thirds died within two years following the first amputation. CONCLUSIONS: The ESRD population is at an extremely high risk of lower limb amputation. Coordinated programs to screen for high-risk feet and to provide regular foot care for those at high risk combined with guidelines for treatment and referral of ulceration are needed.  (+info)

Necrotizing soft tissue infections. (6/271)

Necrotizing soft tissue infections are a group of highly lethal infections that typically occur after trauma or surgery. Many individual infectious entities have been described, but they all have similar pathophysiologies, clinical features, and treatment approaches. The essentials of successful treatment include early diagnosis, aggressive surgical debridement, antibiotics, and supportive intensive treatment unit care. The two commonest pitfalls in management are failure of early diagnosis and inadequate surgical debridement. These life-threatening infections are often mistaken for cellulitis or innocent wound infections, and this is responsible for diagnostic delay. Tissue gas is not a universal finding in necrotizing soft tissue infections. This misconception also contributes to diagnostic errors. Incision and drainage is an inappropriate surgical strategy for necrotizing soft tissue infections; excisional debridement is needed. Hyperbaric oxygen therapy may be useful, but it is not as important as aggressive surgical therapy. Despite advances in antibiotic therapy and intensive treatment unit medicine, the mortality of necrotizing soft tissue infections is still high. This article emphasizes common treatment principles for all of these infections, and reviews some of the more important individual necrotizing soft tissue infectious entities.  (+info)

Epidemiology of the incidence of oro-facial noma: a study of cases in Dakar, Senegal, 1981-1993. (7/271)

Oro-facial noma is an oral gangrene occurring in early childhood in extremely poor areas. As many as 70-90% of those with noma die, and to date, there is no satisfactory treatment to fight this disease. Within the context of the World Health Organization international program against noma, a 13-year retrospective study based on clinical records was carried out in Dakar, Senegal in an attempt to understand the epidemiology of noma. Between 1981 and 1993, 199 cases of noma were identified, among them; 36.7% were acute cases and 63.3% showed sequelae. Chronic sequelae of noma were seen in patients 2-41 years of age, but the acute phase of noma was found only in young children (77.7% in those 1-4 years of age, maximum age = 9 years, mean age +/- SD age = 3.4 +/- 1.9 years). A total of 73.1% of the cases with acute disease were reported in the Dakar, Diourbel and Kaolack regions during the dry season (57.0% of the cases). The lesions of progressive noma were localized mainly on the upper lip (42.4%) and the cheek (31.1%). A total of 96.9% of the patients with acute diseases were had poor general health with serious associated diseases; only 20.0% had a good vital prognosis. The development of epidemiologic surveillance programs for noma should be a public health priority in Senegal.  (+info)

Adjunctive techniques to improve patency of distal prosthetic bypass grafts: polytetrafluoroethylene with remote arteriovenous fistulae versus vein cuffs. (8/271)

PURPOSE: The long-term patency for infrapopliteal bypass grafting with prosthetic material is less than optimal. Our experience demonstrates a 40% patency at 2 years for these grafts. Several adjuvant techniques have been developed to improve patency rates, two of which are a remote distal arteriovenous fistula and the creation of a distal vein cuff. This study summarizes our experience with these two techniques. METHODS: Between 1987 and 1998, 107 bypass graftings were performed to the below-knee popliteal or tibial vessels with the use of polytetrafluoroethylene. One group (48 bypass grafts) had polytetrafluoroethylene with adjuvant distal arteriovenous fistula (DAVF), and a second group (59 bypass grafts) was reconstructed with a distal vein cuff (DVC). The type of bypass grafting that was performed was based on surgeon experience and preference. Indications and demographics were similar in the two groups. All patients underwent the operation for limb-threatening ischemia, including gangrene (DAVF, 23%; DVC, 9%), ulceration (DAVF, 27%; DVC, 51%), and rest pain (DAVF, 50%; DVC, 40%). RESULTS: The primary patency rate was 48% and 38% at 3 years for DAVF and DVC, respectively. Secondary patency was 48% and 47% at 3 years, with limb salvage rates of 76% and 92% for DAVF and DVC, respectively (P <.05). Attempted thrombectomy without continuation of patency was undertaken in two patients with a failed DAVF. Attempts at restoration after thrombosis were made in eight patients with failed DVCs. Five patients underwent thrombectomy, of which four procedures were successful. Three patients had thrombolytic therapy, and two of these remained patent. CONCLUSION: Adjuvant techniques, including DAVF and DVC, produce acceptable long-term patency and limb salvage rates in bypass grafts performed to the below-knee popliteal and tibial vessels. This study suggests that DVCs may offer improved limb salvage rates and a greater opportunity for revision when bypass graft failure occurs.  (+info)

  • Gangrene is the death of tissues in your body. (
  • However, once gangrene has developed, the affected tissues are not salvageable. (
  • Because of its ability to quickly spread to surrounding tissues, gas gangrene should be treated as a medical emergency. (
  • Some kinds of imaging are helpful in diagnosing the spread of gangrene in your internal tissues. (
  • For people with poor circulation that results in gangrene, vascular surgery (surgery on the arteries or veins) may be recommended in order to improve the flow of blood through the veins to body tissues. (
  • It produces gas over tissues where there is gangrene . (
  • Severe frostbite (due to overexposure to the cold) can also lead to gangrene due to lack of proper blood flow to the tissues. (
  • It can help keep the gangrene from spreading to healthy tissues nearby. (
  • Gangrene happens when blood supply to certain tissues is stopped. (
  • Gangrene is the death of a mass of cells or tissues due to reduction in blood supply. (
  • In the early stages, a wound surrounded by redness followed by tissue death with darkened avascular tissue, drainage, air entrapped in the tissues causing a crunching sound with eventual malodorous drainage and red streaks running up the leg followed by fever , sepsis and eventually death may occur in untreated gangrene . (
  • Gangrene results when the entry of oxygen into the tissues ceases or is severely restricted. (
  • Dry gangrene is characterized by the drying up, wrinkling, and compression of tissues (the affected part decreases in size) due to the coagulation of cell proteins and decomposition of formed blood elements. (
  • Initial symptoms of Fournier gangrene include swelling or sudden pain in the scrotum, fever, pallor and generalized weakness. (
  • Fournier gangrene is usually diagnosed clinically, but laboratory tests and imaging studies are used to confirm diagnosis, determine severity and predict outcomes. (
  • Fournier gangrene is a urological emergency requiring intravenous antibiotics and debridement (surgical removal) of necrotic (dead) tissue. (
  • A 2009 epidemiological study found the incidence of Fournier gangrene to be 1.6 cases per 100,000 males, in the United States. (
  • Puerto Rican abolitionist and pro-independence leader Segundo Ruiz Belvis died from Fournier gangrene in November 1867. (
  • Fournier gangrene and Jean Alfred Fournier at Who Named It? (
  • From March 2013, until Jan. 31, 2019, the FDA found 55 cases of this condition, known as Fournier gangrene, in people taking three different types of the SGLT2 inhibitors. (
  • So, she says, even for people who have something that makes the disease more likely and a triggering event, Fournier gangrene remains rare. (
  • For instance, previous research has said about 1.6 men in every 100,000 will get Fournier gangrene, and among men 50 to 79, about 3 in every 100,000 will get it. (
  • So, they reason, if the Fournier gangrene were linked only with diabetes and not the specific drug, they would expect to find far more than 19 cases with the other types of drugs. (
  • Fournier gangrene was first identified in 1883, when the French venereologist Jean Alfred Fournier described a series in which 5 previously healthy young men suffered from a rapidly progressive gangrene of the penis and scrotum without apparent cause. (
  • Impaired immunity (eg, from diabetes) is known to increase susceptibility to Fournier gangrene. (
  • However, the disease was named after Jean-Alfred Fournier, a Parisian venereologist, on the basis of a transcript from an 1883 clinical lecture in which Fournier presented a case of perineal gangrene in an otherwise healthy young man, adding this to a compiled series of 4 additional cases. (
  • In anecdotes, Fournier described recognized causes of perineal gangrene, including placement of a mistress' ring around the phallus, ligation of the prepuce (used in an attempt to control enuresis or as an attempted birth control technique practiced by an adulterous man to avoid impregnating his married lover), placement of foreign bodies such as beans within the urethra, and excessive intercourse in diabetic and alcoholic persons. (
  • The complex anatomy of the male external genitalia influences the initiation and progression of Fournier gangrene. (
  • Therefore, a working knowledge of the anatomy of the male lower urinary tract and external genitalia is critical for the clinician treating a patient with Fournier gangrene. (
  • Because Fournier gangrene is predominately an infectious process of the superficial and deep fascial planes, understanding the anatomic relationship of the skin and subcutaneous structures of the perineum and abdominal wall is important. (
  • Two patients in septic shock due to Fournier gangrene were admitted to the Intensive Care Unit of Emergency Department. (
  • Fournièr's gangrene was primarily described by the French dermatologist Jean Alfred Fournier in 1883. (
  • Will occur fournier gangrene in the foot? (
  • Health care providers prescribing SGLT2 inhibitors to patients with diabetes should have a high index of suspicion for the signs and symptoms of Fournier gangrene, given its substantial morbidity and mortality, according to Susan J. Bersoff-Matcha, MD, and her colleagues at the FDA. (
  • In the previous warning , FDA officials said 12 cases of Fournier gangrene in patients taking an SGLT2 inhibitor had been reported to the agency or in medical literature from March 2013, when the first such inhibitor was approved, and May 2018. (
  • In this latest report, a total of 55 Fournier gangrene cases had been reported in patients receiving SGLT2 inhibitors from March 2, 2013 through January 31, 2019. (
  • The researchers also noted that diabetes is a comorbidity in 32% to 66% of cases of Fournier gangrene. (
  • But the likliehood that diabetes mellitus alone causes Fournier gangrene seems unlikley, given that Dr. Bersoff-Matcha and co-authors only found 19 Fournier gangrene cases associated with other classes of antiglycemic agents reported to the FDA or in the literature over a 35-year time frame. (
  • If Fournier gangrene were associated only with diabetes mellitus and not SGLT2 inhibitors, we would expect far more cases reported with the other antiglycemic agents, considering the 35-year timeframe and the large number of agents," they said in their report. (
  • Serious complications and death are likely if Fournier gangrene is not recognized immediately and surgical intervention is not carried out within the first few hours of diagnosis," they said in the report. (
  • The incidence of Fournier gangrene in patients taking SGLT2 inhibitors can't be established by these cases reported to the FDA, which are spontaneously provided by health care providers and patients, investigators said. (
  • 2018. (
  • If ischemia is detected early, when ischemic wounds rather than gangrene are present, the process can be treated by revascularization (via vascular bypass or angioplasty). (
  • Louis Pasteur first observed garlic's antibacterial qualities in 1858, and until World War II is was routinely used to prevent gangrene in patients with infected wounds. (
  • Gas gangrene rose to prominence during World War I. The incidence amongst civilians was low but gas gangrene complicated 6% of open fractures and 1% of open wounds in military personal. (
  • gas gangrene a condition often resulting from dirty, lacerated wounds in which the muscles and subcutaneous tissue become filled with gas and a serosanguineous exudate. (
  • Internal causes include states and processes that interfere with tissue nutrition, mainly injuries to blood vessels-wounds, arterial occlusions, and constriction of blood vessels by spasms or anatomical changes, such as those occurring in atherosclerosis, which often causes infarcts, thrombosis, and senile gangrene. (
  • Gangrene is a type of tissue death caused by not enough blood supply. (
  • Gangrene is caused due to tissue death that results from stoppage of blood supply to the affected organ. (
  • Gangrene has been recognized as a localized area of tissue death since ancient times. (
  • Twisting of any portion of the intestines may cut off the supply of blood to a loop of bowel (strangulation), reducing the flow of oxygen to bowel tissue (ischemia) and leading to tissue death ( gangrene ). (
  • If you have symptoms of gangrene, your healthcare team will give you a physical exam to check for signs of tissue death. (
  • Similarly, peripheral artery disease leads to fatty deposits in the arteries and stops blood from flowing to the fingers and toes leading to gangrene. (
  • Gangrene may affect small areas, such as fingers or toes that have been frostbitten, or larger areas of tissue, such as part of the foot. (
  • Fulminant gangrene of the fingers, toes and nose developed in a 57-year-old woman with Escherichia coli pneumonia. (
  • A champion bagpipe player had to have all his fingers and toes amputated after he developed gangrene which nearly killed him. (
  • I developed severe dry gangrene on right foot after trauma, 4 toes already amputated, but it is spreading very slow. (
  • I have lots of dry gangrene on right foot, lost 4 toes, but it doesn't go past the mid-foot. (
  • Complications depend on where in the body the gangrene is, how much gangrene there is, the cause of the gangrene, and the person's overall condition. (
  • Wet gangrene can spread much quicker leading to life-threatening complications like septic shock if not treated immediately. (
  • People with diabetes and peripheral artery disease are especially vulnerable to complications such as gangrene, because, in addition to poor blood circulation , they often have decreased sensation in their feet due to nerve damage. (
  • What are the complications of gangrene? (
  • Arteriosclerosis leads to thickened walls of the arteries or formation of cholesterol plaques and narrowing of the diameter of the small vessels leading to gangrene. (
  • Most cases of dry gangrene result from insufficient blood flowing through the arteries, usually due to diabetes, high cholesterol , or smoking. (
  • Vascular - gangrene is seen is vascular diseases such as peripheral arteriosclerosis, thrombosis of the large arteries, thrombosis of terminal aorta etc. (
  • Dry gangrene is caused by a reduction of blood flow through the arteries. (
  • Dry gangrene is commonly seen in people with blockage of arteries ( arteriosclerosis ) resulting from increased cholesterol levels , diabetes , cigarette smoking , and genetic and other factors. (
  • Gangrene tends to happen more often among people with peripheral artery disease , a common circulatory problem in which narrowed arteries reduce blood flow to the limbs. (
  • It is characterized by obliterative endarteritis and thrombosis of the subcutaneous arteries resulting in gangrene of the subcutaneous tissue and overlying skin. (
  • Gas ("wet") gangrene is the most life-threatening form of gangrene. (
  • This form of gangrene spreads very quickly, and can cause a rapid death. (
  • Physical examination of the affected area is performed to look for signs of gangrene. (
  • What are the signs of gangrene, and how can it be avoided? (
  • A 40 year old male came to the emergency room of the homeopathic hospital complaining of severe, agonizing pain in his right foot with signs of gangrene , cellulites and toxemia. (
  • Dry gangrene can result from conditions that reduce or block arterial blood flow such as diabetes , arteriosclerosis , and tobacco addiction as well as from trauma , frostbite , or injury. (
  • [ 6 ] He differentiated these cases from perineal gangrene associated with diabetes, alcoholism, or known urogenital trauma, although these are currently recognized risk factors for the perineal gangrene now associated with his name. (
  • Gas gangrene can be a result of surgery or trauma. (
  • Usually, the progression of dry gangrene is much slower (days to months) than wet gangrene because the vascular compromise slowly develops due to the progression of diseases that can result in local arterial blockage over time. (
  • For example, peripheral vascular disease in which blood flow to the legs is poor can deprive a foot or leg of blood or oxygen, resulting in gangrene. (
  • The vascular surgeon told my mother she has early stages of gangrene in her foot. (
  • Wet gangrene can develop following a severe burn or frostbite . (
  • If it is severe, gangrene sometimes requires that a part of the body, such as a finger, toe, or foot, be amputated. (
  • In severe cases of cholecystitis , which is usually associated with gallstones , gangrene may develop where the stones compress the mucous membrane. (
  • Severe cases of gangrene may lead to organ failure and even death. (
  • We conclude that venous limb ischemia/gangrene is explained in some cancer patients by profoundly disturbed procoagulant-anticoagulant balance, whereby warfarin fails to block cancer-associated hypercoagulability while nonetheless contributing to severe PC depletion, manifest as a characteristic supratherapeutic INR caused by parallel severe factor VII depletion. (
  • If the gangrene is internal, you may run a fever and feel unwell, and the area may be swollen and painful. (
  • There is also a certain type of wet gangrene, called gas gangrene , in which an infected wound is swollen, painful, and produces bloody discharge, often resulting in a fever and irregular heartbeat. (
  • A man's entire penis fell off after it rotted away because of gangrene triggered during surgery to treat cancer in his neck. (
  • The gangrene had spread along the penis shaft and, although surgeons tried to cut away the infected flesh to save the man's penis, it eventually became so destroyed it dropped off. (
  • A case of superficial gangrene of penis after insertion of a malleable penile prosthesis is presented. (
  • May 8, 2019 -- Popular diabetes drugs known as SGLT2 inhibitors appear to raise the chance of getting gangrene of the genital area, a rare but potentially fatal side effect, according to a new report. (
  • About 1,000 cases of gas gangrene are reported yearly in the United States. (
  • Blood vessel diseases such as atherosclerosis commonly cause dry gangrene. (
  • Dry gangrene can result from any of a number of diseases or mechanisms that can reduce or block arterial blood flow. (
  • Although the most common diseases that can cause dry gangrene are diabetes , arteriosclerosis, and tobacco addiction, there are many other lesser-known diseases that can lead to this problem. (
  • For example, some autoimmune diseases that attack blood vessels ( vasculitis syndromes) may result in enough damage to cause dry gangrene. (
  • Autoimmune diseases such as lupus erythematosus, sclerederma and rheumatoid arthritis may be associated with Raynaud phenomenon and gangrene. (
  • This information refers to the general prevalence and incidence of these diseases, not to how likely they are to be the actual cause of Gangrene. (
  • ICD-9 code 550.03 for Recurrent bilateral inguinal hernia with gangrene is a medical classification as listed by WHO under the range -HERNIA OF ABDOMINAL CAVITY (550-553). (
  • ICD-9 code 550.92 for Bilateral inguinal hernia without obstruction or gangrene is a medical classification as listed by WHO under the range -HERNIA OF ABDOMINAL CAVITY (550-553). (
  • In 1764, Baurienne originally described an idiopathic, rapidly progressive soft-tissue necrotizing process that led to gangrene of the male genitalia. (
  • At the time of arrival in the ER, the patient had reached a toxic stage of the snake bite and there was a possibility of incipient septecaemia in addition to the rapidly extending cellulitis, and local gangrene that had already developed. (
  • Because gangrene can spread rapidly over a large area of the body, the amount of dead tissue can be quite large. (
  • Gas gangrene continues to cause significant morbidity and mortality. (
  • In this kind of gangrene, a person's tissue will dry and shrivel. (