Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.
A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)
An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.
Substances used to allow enhanced visualization of tissues.
A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)
A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.
The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)
A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.
Americium. A completely man-made radioactive actinide with atomic symbol Am, atomic number 95, and atomic weight 243. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy.
Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.
1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.
Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)
An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.
Porphyrins which are combined with a metal ion. The metal is bound equally to all four nitrogen atoms of the pyrrole rings. They possess characteristic absorption spectra which can be utilized for identification or quantitative estimation of porphyrins and porphyrin-bound compounds.
Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.
Graphic tracing over a time period of radioactivity measured externally over the kidneys following intravenous injection of a radionuclide which is taken up and excreted by the kidneys.
Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).
Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.
Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.
Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.
Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.
The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)
Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.
Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.
The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
Elements of limited time intervals, contributing to particular results or situations.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
The study of the chemical and physical phenomena of radioactive substances.
An involuntary or voluntary pause in breathing, sometimes accompanied by loss of consciousness.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.
A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).
A technique for analysis of the chemical composition of molecules. A substance is bombarded with monochromatic ELECTRONS. Some of the electrons passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The energy loss is element dependent. Analysis of the energy loss spectrum reveals the elemental composition of a specimen. ENERGY-FILTERED TRANSMISSION ELECTRON MICROSCOPY is a type of electron energy loss spectroscopy carried out in electron microscopes specially outfitted to analyze the spectrum of electron energy loss.
The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Hypertension due to RENAL ARTERY OBSTRUCTION or compression.
Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).
A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).
Transmission of energy or mass by a medium involving movement of the medium itself. The circulatory movement that occurs in a fluid at a nonuniform temperature owing to the variation of its density and the action of gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed; Webster, 10th ed)
The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.
Iron (II,III) oxide (Fe3O4). It is a black ore of IRON that forms opaque crystals and exerts strong magnetism.
Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.
Injections made into a vein for therapeutic or experimental purposes.
Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.
Reduction of CEREBROSPINAL FLUID pressure characterized clinically by HEADACHE which is maximal in an upright posture and occasionally by an abducens nerve palsy (see ABDUCENS NERVE DISEASES), neck stiffness, hearing loss (see DEAFNESS); NAUSEA; and other symptoms. This condition may be spontaneous or secondary to SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)
The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.
An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.
Chemical agents that increase the permeability of CELL MEMBRANES to CALCIUM ions.
Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).
A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.
Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.
A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.
Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).
The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.
Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.
Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.
Cyclic N-oxide radical functioning as a spin label and radiation-sensitizing agent.
The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)
A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.
Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI. (1/1258)

The aim of this study was two-fold: to compare 67Ga scintigraphy with MRI (a) for the staging of malignant lymphoma of the bone and (b) with regard to accuracy in detecting residual disease after first-line chemotherapy for restaging. METHODS: Twenty-one patients with 36 malignant osseous lesions were examined, including 7 patients with primary or multifocal osseous lymphoma and 14 patients with malignant lymphoma and simultaneous or secondary involvement of the bone. After first-line therapy, MRI and 67Ga scintigraphy were performed on 13 patients. The remission status based on all clinical and radiological findings during the follow-up was used as the gold standard. RESULTS: The osseous lesions were located on the axial skeleton in 64% of patients and on the appendicular skeleton in 36%. 67Ga scintigraphy detected 77% of the osseous lesions examined by MRI. For restaging after first-line therapy, MRI had a sensitivity of 90% and a specificity of 80% when dynamic MRI information was included. There were several false-positive results as a result of the pathologic increase in signal intensity ratios of reactive hematopoietic regions after chemotherapy. For 67Ga scintigraphy, a sensitivity of 70% and a specificity of 93% were calculated. CONCLUSION: These data show that monitoring malignant lymphoma of the bone still presents diagnostic problems. Given the high sensitivity of MRI and the high specificity of 67Ga scintigraphy but the limited specificity of MRI and sensitivity of 67Ga scintigraphy, both methods are valuable but should be used as complementary diagnostic tools.  (+info)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1258)

Annular tears are manifest on MRI as the high-intensity zone (HIZ) or as annular enhancement. Patients with annular tears may experience low back pain with radiation into the lower limb in the absence of nerve root compression. Inflammation of nerve roots from leak of degenerative nuclear material through full-thickness annular tears is a proposed mechanism for such leg pain. The aim of this study is to illustrate the appearance of extradural enhancement adjacent to annular tears in patients being investigated for low back pain with radiation into the lower limb(s). Sagittal T1- and T2-weighted spin echo and axial T1-weighted spin echo sequences were obtained in eight patients being investigated for low back and leg pain. In all patients, the T1-weighted sequences were repeated following intravenous gadopentetate dimeglumine (Gd-DTPA). Annular tears were identified at 12 sites in eight patients. Extradural inflammation appeared as a region of intermediate signal intensity replacing the fat between the posterior disc margin and the theca, which enhanced following Gd-DTPA. The inflammatory change was always associated with an annular tear, and in four cases directly involved the nerve root. Enhancement of the nerve root was seen in two cases. The findings may be relevant in the diagnosis of chemical radiculopathy secondary to inflammation at the site of an annular leak from a degenerating disc.  (+info)

A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. (3/1258)

OBJECTIVES: The purpose of this study was to evaluate a myocardial perfusion reserve index (MPRI) derived from a quantitative magnetic resonance imaging (MRI) technique in normal human volunteers and patients with coronary artery disease and to relate MPRI to coronary artery stenosis severity measured with quantitative arteriography. BACKGROUND: Magnetic resonance imaging could be a useful noninvasive tool in the investigation of ischemic heart disease. However, there have been few studies in humans to quantify myocardial perfusion and myocardial perfusion reserve using MRI and none in patients with coronary disease. METHODS: Twenty patients with angiographically proven coronary artery disease and five normal volunteers underwent both resting and stress (adenosine 140 microg/kg(-1)/min(-1)) first-pass contrast-enhanced MRI examinations (using 0.05 mmol/kg 1 of gadopentetate dimeglumine. Using a tracer kinetic model, the unidirectional transfer constant (K(i)), a perfusion marker for the myocardial uptake of contrast, was computed in each coronary arterial territory. The ratio of K(i) for the rest and stress scans was used to calculate the MPRI. Percent reduction in luminal diameter of coronary lesions was measured using an automated edge-detection algorithm. RESULTS: Myocardial perfusion reserve index was significantly reduced in patients compared with normal subjects (2.02+/-0.7 vs. 4.21+/-1.16, p < 0.02). For regions supplied by individual vessels, there was a significant negative correlation of MPRI with percent diameter stenosis (r = -0.81, p < 0.01). Importantly, regions supplied by vessels with <40% diameter stenosis (non-flow limiting) had a significantly higher MPRI than regions supplied by stenoses of "intermediate" severity, that is, >40% to 59% diameter stenosis (2.80+/-0.77 and 1.93+/-0.38, respectively, p < 0.02). However, even regions supplied by vessels with <40% diameter stenosis had a significantly lower MPRI than volunteers (p < 0.01). CONCLUSIONS: A myocardial perfusion reserve index derived from first-pass MRI studies can distinguish between normal subjects and patients with coronary artery disease. Furthermore, it provides useful functional information on coronary lesions, particularly where the physiologic significance cannot be predicted accurately from the angiogram.  (+info)

Statistical power of MRI monitored trials in multiple sclerosis: new data and comparison with previous results. (4/1258)

OBJECTIVES: To evaluate the durations of the follow up and the reference population sizes needed to achieve optimal and stable statistical powers for two period cross over and parallel group design clinical trials in multiple sclerosis, when using the numbers of new enhancing lesions and the numbers of active scans as end point variables. METHODS: The statistical power was calculated by means of computer simulations performed using MRI data obtained from 65 untreated relapsing-remitting or secondary progressive patients who were scanned monthly for 9 months. The statistical power was calculated for follow up durations of 2, 3, 6, and 9 months and for sample sizes of 40-100 patients for parallel group and of 20-80 patients for two period cross over design studies. The stability of the estimated powers was evaluated by applying the same procedure on random subsets of the original data. RESULTS: When using the number of new enhancing lesions as the end point, the statistical power increased for all the simulated treatment effects with the duration of the follow up until 3 months for the parallel group design and until 6 months for the two period cross over design. Using the number of active scans as the end point, the statistical power steadily increased until 6 months for the parallel group design and until 9 months for the two period cross over design. The power estimates in the present sample and the comparisons of these results with those obtained by previous studies with smaller patient cohorts suggest that statistical power is significantly overestimated when the size of the reference data set decreases for parallel group design studies or the duration of the follow up decreases for two period cross over studies. CONCLUSIONS: These results should be used to determine the duration of the follow up and the sample size needed when planning MRI monitored clinical trials in multiple sclerosis.  (+info)

Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits. (5/1258)

BACKGROUND/AIMS: To investigate a poly(2-hydroxyethyl methacrylate) (PHEMA) orbital implant with a spongy anterior hemisphere and a smooth gel posterior hemisphere, by histology correlated with magnetic resonance images. METHODS: Following enucleation, eight rabbits received PHEMA implants to which the muscles were directly sutured, and underwent gadolinium enhanced magnetic resonance imaging (MRI) from 3 to 52 weeks. After the rabbits were killed, the implants were removed, cut in a plane corresponding to the scan, and processed for light and electron microscopy. RESULTS: All eight rabbits retained their implant to the end of the study period without complications. The scans demonstrated muscle attachment to the anterior half of the implant, and enhancement was seen on injection of gadolinium chelate. Histology confirmed muscle attachment, and cellular and vascular ingrowth. Over time, a transformation from reactive inflammatory to relatively non-vascular scar tissue was seen within the implant. Calcium deposits in one implant were detected by imaging and histology. CONCLUSION: The implants are readily visualised on MRI. Muscle attachment and fibrovascular ingrowth into the anterior hemisphere are seen, while encapsulation of the posterior hemisphere is minimal. Histological findings confirm the progress of the healing response, with initial inflammation and marked vascularisation, developing later into quiescent scar tissue predominantly of fibroblasts.  (+info)

Cell water balance of white button mushrooms (Agaricus bisporus) during its post-harvest lifetime studied by quantitative magnetic resonance imaging. (6/1258)

A combination of quantitative water density and T2 MRI and changes therein observed after infiltration with 'invisible' Gd-DTPA solution was used to study cell water balances, cell water potentials and cell integrity. This method was applied to reveal the evolution and mechanism of redistribution of water in harvested mushrooms. Even when mushrooms did not lose water during the storage period, a redistribution of water was observed from stipe to cap and gills. When the storage condition resulted in a net loss of water, the stipe lost more water than the cap. The water density in the gill increased, probably due to development of spores. Deterioration effects (i.e. leakage of cells, decrease in osmotic water potential) were found in the outer stipe. They were not found in the cap, even at prolonged storage at 293 K and R.H.=70%. The changes in osmotic potential were partly accounted for by changes in the mannitol concentration. Changes in membrane permeability were also indicated. Cells in the cap had a constant low membrane (water) permeability. They developed a decreasing osmotic potential (more negative), whereas the osmotic potential in the outer stipe increased, together with the permeability of cells.  (+info)

Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. (7/1258)

Lipoblastomatosis is a locally infiltrative tumor of embryonic fat. We describe the MR appearance of cervical lipoblastomatosis with epidural extension. The initial MR study showed features of a soft-tissue mass; a subsequent MR examination, performed after chemotherapy, depicted the lesion as a typical lipoma of high signal intensity on T1-weighted images and of intermediate signal on T2-weighted sequences.  (+info)

Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (8/1258)

We describe imaging findings in a 2-year-old girl with neurocutaneous melanosis and malignant cerebral melanoma. Because the cerebral melanoma in this child was of the amelanotic type, high-signal intensity on unenhanced T1-weighted images was not present. The cutaneous lesions played a crucial role in establishing a correct (presumed) histopathologic diagnosis on the basis of the imaging findings. To our knowledge this is the first report describing an intracranial amelanotic malignant melanoma in association with neurocutaneous melanosis.  (+info)

We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity of brain MRI for detecting enhancing lesions in patients with MS. We obtained T1-weighted brain MRI scans in two sessions for 22 patients with clinically definite MS. In the first session, we obtained one scan 5 to 7 minutes after the injection of 0.1 mmol/kg gadolinium-DTPA (standard dose). In the second session, 6 to 24 hours later, we obtained one scan before the two scans 5 to 7 minutes (for all patients) and one hour (for 11 patients) after the injection of 0.3 mmol/kg gadolinium-DTPA (triple dose). We detected 83 enhancing lesions in 14 patients when the standard dose of gadolinium-DTPA was used. The numbers of enhancing lesions increased to 138 (average increase 66%; p = 0.001) and the numbers of patients with such lesions to 18 (increase 28%) when we used the triple dose of gadolinium-DTPA. In addition, the total area per patient occupied by such lesions was greater ...
TY - JOUR. T1 - Thoracic aorta. T2 - Comparison of single-dose breath-hold and double-dose non-breath-hold gadolinium-enhanced three-dimensional MR angiography. AU - Krinsky, Glenn A.. AU - Reuss, Peter M.. AU - Lee, Vivian S.. AU - Carbognin, Giovanni. AU - Rofsky, Neil M.. PY - 1999/7. Y1 - 1999/7. N2 - OBJECTIVE. The purpose of this study was to compare single-dose (0.1 mmol/kg) breath-hold gadolinium-enhanced three-dimensional (3D) MR angiography and double-dose (0.2 mmol/kg) non-breath-hold 3D MR angiography for evaluation of thoracic aortic disease. MATERIALS AND METHODS. Twenty- five patients referred for MR evaluation of the thoracic aorta underwent non- breath-hold gadolinium-enhanced 3D MR angiography on a 1.5-T scanner with standard gradients (TR/TE, 21/6; flip angle, 30°) during slow infusion of a double dose of gadopentetate dimeglumine using a body coil. Subsequently, the same patients underwent breath-hold MR imaging with high-performance gradients (TR/TE, 5/2; flip angle, ...
Poor drug delivery to brain tumors caused by aberrant tumor vasculature and a partly intact blood-brain barrier (BBB) and blood-brain tumor barrier (BTB) can significantly impair the efficacy of chemotherapy. Determining drug delivery to brain tumors is a challenging problem, and the noninvasive detection of drug directly in the tumor can be critically important for accessing, predicting, and eventually improving effectiveness of therapy. In this study, in vivo magnetic resonance spectroscopy (MRS) was used to detect an anticancer agent, temozolomide (TMZ), in vivo in murine xenotransplants of U87MG human brain cancer. Dynamic magnetic resonance imaging (MRI) with the low-molecular-weight contrast agent, gadolinium diethylenetriaminepentaacetic acid (GdDTPA), was used to evaluate tumor vascular parameters. Carbon-13-labeled TMZ ([C-13]TMZ, 99%) was intraperitoneally administered at a dose of similar to 140 mg/kg (450 mg/m(2), well within the maximal clinical dose of 1000 mg/m(2) used in humans) ...
Gadopentetate dimeglumine (also known as MagnevistTM) is an extracellular intravenous contrast agent used in magnetic resonance imaging. linear, ionic molecule 100% renally excreted T1 relaxivity @ 1.5 T: 3.9-4.3 concentration: 0.5 mmol/mL ...
Easy-to-read patient leaflet for Gadopentetate Dimeglumine. Includes indications, proper use, special instructions, precautions, and possible side effects.
Magnetic resonance imaging (MRI) detection of synovitis and bone lesions of the wrists and finger joints in early-stage rheumatoid arthritis : comparison of the accuracy of plain MRI-based findings and gadolinium-diethylenetriamine pentaacetic acid-enhanced MRI-based findings (2012 ...
T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction at 3T for Gd-DTPA and Gd-BOPTA : Purpose Myocardial T1 relaxation time (T1 time) and extracellular volume fraction (ECV) are altered in patients with diffuse myocardial fibrosis. The purpose of this study was to perform an intra-individual assessment of normal T1 time and ECV for two different contrast agents. Methods A modified Look-Locker Inversion Recovery (MOLLI) sequence was acquired at 3 T in 24 healthy subjects (8 men; 28
Objective: While liver biopsy is the golden standard for liver-fibrosis diagnosis, it is also invasive and has many limitations. Non-invasive techniques such as
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RESULTS Considering the whole group of MR examinations performed either without (n = 26) or without and with intravenous injection of gadopentetate dimeglumine (n = 16), overall 20 MR studies were judged to show disease. Seventeen of 26 microadenomas were adequately shown and located by MR (true-positive, 65.4%). In three cases the sides of the microadenomas were misjudged (false-positive, 11.5%). Six patients had negative MR studies (false-negative, 23%). Twelve of the 16 patients studied after gadopentetate dimeglumine injection had true-positive MR findings (75%).. ...
Cardio-vascular magnetic resonance imaging (CMR) can be used to obtain integrated information on both cardiac function and on advanced tissue characteristics. Using contrast-enhanced techniques, highly diagnostic information on tissue viability, infl
OBJECTIVE. We compared the diagnostic performance of gadoxetic acid-enhanced MRI with that of triple-phase 16-, 40-, and 64-MDCT in the preoperative detection of hepatocellular carcinoma (HCC).. SUBJECTS AND METHODS. Sixty-two consecutively registered patients (54 men, eight women; age range, 31-67 years) with 83 HCCs underwent triple-phase (arterial, portal venous, equilibrium) CT at 16-, 40-, or 64-MDCT and gadoxetic acid-enhanced 3-T MRI. The diagnosis of HCC was established after surgical resection. Three observers independently and randomly reviewed the MR and CT images on a tumor-by-tumor basis. The diagnostic accuracy of these techniques in the detection of HCC was assessed with alternative free response receiver operating characteristic (ROC) analysis. Sensitivity, positive and negative predictive values, and sensitivity according to tumor size were evaluated.. RESULTS. For each observer, the areas under the ROC curve were 0.971, 0.959, and 0.967 for MRI and 0.947, 0.950, and 0.943 for ...
TY - JOUR. T1 - Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T. AU - Yankeelov, Thomas E.. AU - DeBusk, Laura M.. AU - Billheimer, D. Dean. AU - Luci, Jeffrey J.. AU - Lin, P. Charles. AU - Price, Ronald R.. AU - Gore, John C.. PY - 2006/11. Y1 - 2006/11. N2 - Purpose: To test the repeatability of a reference region (RR) model for the analysis of dynamic contrast-enhanced MRI (DCE-MRI) in a mouse model of cancer at high field. Materials and Methods: Seven mice were injected with 10 6 4T1 mammary carcinoma cells and imaged eight to 10 days later on a Varian 7.0T scanner. Two DCE-MRI studies were performed for each mouse (separated by 2.5 hours). The RR model was used to analyze the data, and returned estimates on the perfusion-permeability index (Ktrans) for the RR and the tissue of interest (TOI), as well as the extravascular extracellular volume fraction (ve) for the TOI. Results: When the first injection was compared with the second injection, all ...
For the standard- versus double-dose clopidogrel comparison, when pooling the two aspirin strata together, there was no difference in the primary endpoint of cardiovascular death, MI, or stroke at 30 days (4.4% for standard-dose vs. 4.2% for double-dose, HR 0.95, 95% CI 0.84-1.07, p = 0.37). There was a significant interaction with performance of PCI (p-interaction = 0.016), with a lower rate of the primary endpoint with double-dose clopidogrel versus standard-dose clopidogrel in the PCI cohort (4.5% vs. 3.9%, HR 0.85, 95% CI 0.74-0.99) and a numerically higher rate of the primary endpoint with double-dose clopidogrel in the no PCI cohort (4.2% vs. 4.9%, HR 1.17, 95% CI 0.95-1.44). There was also no difference overall in the individual components of the composite endpoint of cardiovascular death (2.2% vs. 2.1%, HR 0.96, 95% CI 0.81-1.14, p = 0.63), MI (2.2% vs. 1.9%, HR 0.86, 95% CI 0.73-1.03, p = 0.097), or stroke (0.5% each, p = 0.95) for standard- versus double-dose clopidogrel, respectively. ...
2-((3-Ethoxybenzyl)amino)ethanol/ACM889949659 can be provided in Alfa Chemistry. We are dedicated to provide our customers the best products and services.
The porcine model is increasingly being used in neuroscience research as the large brain volume and similarity of cortical and subcortical anatomy to the human brain may offer increased translational relevance over rat and non-human primate models. The aims of this recently published study using convection enhanced delivery (CED) in pig brains were two-fold: (1) To assess the targeting and to determine distribution volumes of MANF in porcine putamen and substantia nigra and (2) to correlate the distribution volumes of MANF with co-infused gadolinium-DTPA.. Using a recessed-step catheter design it was possible to achieve reflux-free infusions in both putamen and substantia nigra. The volumes of distribution of gadolinium-DTPA and MANF were determined by real-time magnetic resonance imaging (MRI) and immunohistochemical analysis, respectively. The authors concluded that the distributions of gadolinium-DTPA and MANF correlated well and that co-infusion of gadolinium as a proxy measure of MANF ...
acquisition acquisitions administered aetiology affected agent association body breathing cardiac challenge channel chest chronic class clear clinical coil content contrast core coronal days defined dependent diagnosis distinguish dose dynamic either enabling endothelial endpoint endpoints enhanced enrolled established evaluable evaluate evaluated evaluation exercise existing experimental explore failure female fluid fraction free gradient graph graves half healthy heart hospitals included index induced injected injector interpolated interstitial intravenous king kingdom leakage leaving lung lungs male mapping maps martin mass matrix measures measuring mechanism medicine mild minute model moderate novel parker patient patients permeability plasma population position post potential power previously primary problematic proof protocol pulmonary quantification quantifying ranging redistribution registration remains repeat repeatability repeated resolution respective respectively rest rosemary saline ...
Maecenas tempor, ex at maximus efficitur, felis sem ultrices ligula, ut hendrerit purus eros ac urna. Vestibulum ut vestibulum tortor. Orci varius natoque penatibus et magnis dis parturient montes, nascetur ridiculus mus. Cras eu lectus quam. Nunc ligula arcu, auctor sit amet tellus eleifend, facilisis laoreet odio. Donec placerat urna eleifend blandit porttitor.. Nunc magna turpis, tristique at dictum vel, sollicitudin blandit felis. Morbi aliquam elit et pellentesque vulputate. Donec elementum, ante quis ornare porttitor, tortor dolor vestibulum velit, et viverra enim massa vitae ex.. ...
Gadodiamide is a contrast agent that produces magnetic effects. It is used in combination with magnetic resonance imaging (MRI) to allow blood vessels, organs, and other non-bony tissues to be seen more clearly on the MRI. Gadodiamide is used to help diagnose certain disorders of the brain and spine (central nervous...
Each subject will receive HBPM at baseline, week 2, week 6 and week 10 respectively.For baseline HBPM, it was performed in the evening before visit 2 and in the morning of visit 2(before intake of study drug). in terms of the following 3 times of HBPM, they are performed during 5 days before each visit ...
Solvate of (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol with 2-butyne-1, 4-diol (1:1) ...
Automatic software for extracellular volume fraction mapping in the myocardium. Crossref DOI link: https://doi.org/10.1186/1532-429X-17-S1-W34 Published: 2015-12. Update policy: https://doi.org/10.1007/SPRINGER_CROSSMARK_POLICY. ...
METHODS: In this blinded randomized crossover study, 20 patients with known myocardial infarction underwent two separate delayed-enhancement MRI examinations after receiving 0.1 mmol/kg gadobenate dimeglumine and 0.2 mmol/kg gadopentetate dimeglumine (random administration). The conspicuity of lesion enhancement 5, 10, and 20 minutes after contrast administration was quantified as relative enhancement ratio (RER).. RESULTS: With either gadolinium-based contrast agent, damaged myocardium had higher signal intensity than normal remote myocardium (RER , 4) on delayed-enhancement MR images, and the blood RER declined over time after contrast administration. The blood RER was not significantly higher for gadobenate dimeglumine than for gadopentetate dimeglumine at 5 and 10 minutes. Nevertheless, there was a larger reduction in blood RER for gadobenate dimeglumine than for gadopentetate dimeglumine between 5 and 10 minutes and between 10 and 20 minutes. The volumes of enhancement were similar for ...
TY - JOUR. T1 - Liver perfusion changes occurring during pancreatic islet engraftment. T2 - A dynamic contrast-enhanced magnetic resonance study. AU - Esposito, A.. AU - Palmisano, A.. AU - Maffi, P.. AU - Malosio, M. L.. AU - Nano, R.. AU - Canu, T.. AU - De Cobelli, F.. AU - Piemonti, L.. AU - Ironi, G.. AU - Secchi, A.. AU - Del Maschio, A.. PY - 2014/1. Y1 - 2014/1. N2 - The aim of this study was to investigate liver microvascular adaptation following the intraportal infusion of pancreatic islets (pancreatic islet transplantation [islet-tx]) in diabetic patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI was performed before and 7 days after islet-tx in six diabetic patients. Initial area under curve (AUC60) and volume transfer coefficient (Ktrans) were assessed as markers of liver perfusion. Clinical and metabolic monthly follow-up was performed in all patients, considering fasting C-peptide and β-score as main indices of graft function. High variability ...
How is T1-weighted, gadolinium-enhanced magnetic resonance Imaging abbreviated? T1-MRI stands for T1-weighted, gadolinium-enhanced magnetic resonance Imaging. T1-MRI is defined as T1-weighted, gadolinium-enhanced magnetic resonance Imaging rarely.
TY - JOUR. T1 - Antiangiogenic therapy for primary liver cancer. T2 - Correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response. AU - Yopp, Adam C.. AU - Schwartz, Lawrence H.. AU - Kemeny, Nancy. AU - Gultekin, David H.. AU - Gönen, Mithat. AU - Bamboat, Zubin. AU - Shia, Jinru. AU - Haviland, Dana. AU - DAngelica, Michael I.. AU - Fong, Yuman. AU - Dematteo, Ronald P.. AU - Allen, Peter J.. AU - Jarnagin, William R.. PY - 2011/8/1. Y1 - 2011/8/1. N2 - Background: This study utilized the imaging data of primary liver cancer (PLC) treated with floxuridine (FUDR) and bevacizumab to test the hypothesis that dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) parameters correlate with tissue hypoxia markers and treatment outcome. Methods: Seventeen patients with PLC were treated with hepatic artery infusional (HAI) FUDR for 14 days followed by systemic bevacizumab therapy. DCE-MRI images were obtained at baseline ...
TY - GEN. T1 - Segmentation and classification of breast tumor using dynamic contrast-enhanced MR images. AU - Zheng, Yuanjie. AU - Baloch, Sajjad. AU - Englander, Sarah. AU - Schnall, Mitchell D.. AU - Shen, Dinggang. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Accuracy of automatic cancer diagnosis is largely determined by two factors, namely, the precision of tumor segmentation, and the suitability of extracted features for discrimination between malignancy and benignancy. In this paper, we propose a new framework for accurate characterization of tumors in contrast enhanced MR images. First, a new graph cut based segmentation algorithm is developed for refining coarse manual segmentation, which allows precise identification of tumor regions. Second, by considering serial contrast-enhanced images as a single spatio-temporal image, a spatio-temporal model of segmented tumor is constructed to extract Spatio-Temporal Enhancement Patterns (STEPs). STEPs are designed to capture not only dynamic ...
Antivascular treatments can either be antiangiogenic or targeting established tumour vasculature. These treatments affect the tumour microvasculature and microenvironment but may not change clinical measures like tumour volume and growth. In research on antivascular treatments, information on the tumour vasculature is therefore essential. Preclinical research is often used for optimization of antivascular drugs alone or in combined treatments. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is an in vivo imaging method providing vascular information, which has become an important tool in both preclinical and clinical research. This review discusses common DCE-MRI imaging protocols and analysis methods and provides an overview of preclinical research on antivascular treatments utilizing DCE-MRI.
Heterogeneity is a common finding within tumours. We evaluated the imaging features of tumours based on the decomposition of tumoural dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data to identify their prognostic value for breast cancer survival and to explore their biological importance. Imaging features (n = 14), such as texture, histogram distribution and morphological features, were extracted to determine their associations with recurrence-free survival (RFS) in patients in the training cohort (n = 61) from The Cancer Imaging Archive (TCIA). The prognostic value of the features was evaluated in an independent dataset of 173 patients (i.e. the reproducibility cohort) from the TCIA I-SPY 1 TRIAL dataset. Radiogenomic analysis was performed in an additional cohort, the radiogenomic cohort (n = 87), using DCE-MRI from TCGA-BRCA and corresponding gene expression data from The Cancer Genome Atlas (TCGA). The MRI tumour area was decomposed by convex analysis of mixtures (CAM), resulting
TY - JOUR. T1 - Ring-like enhancement of focal nodular hyperplasia with hepatobiliary-phase Gd-EOB-DTPA-enhanced magnetic resonance imaging. T2 - Radiological-pathological correlation. AU - Fujiwara, Hiroyasu. AU - Sekine, Shigeki. AU - Onaya, Hiroaki. AU - Shimada, Kazuaki. AU - Mikata, Rintaro. AU - Arai, Yasuaki. PY - 2011/12. Y1 - 2011/12. N2 - We report a case of focal nodular hyperplasia in a patient for whom gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)- enhanced magnetic resonance imaging (MRI) and histological analysis results were available. Dynamic contrast-enhanced computed tomography showed a well-defi ned hypervascular lesion 14 mm in diameter with no visible central scars. Gd-EOB-DTPA-enhanced MRI demonstrated strong peripheral enhancement of the lesion during the hepatobiliary phase, resulting in ring-like enhancement. The pathology examination revealed that the lesion was focal nodular hyperplasia (FNH). Immunohistochemistry showed positive expression ...
TY - JOUR. T1 - Quantitative parameters in dynamic contrast-enhanced magnetic resonance imaging for the detection and characterization of prostate cancer. AU - Wei, Cheng. AU - Jin, Bowen. AU - Szewczyk-Bieda, Magdalena. AU - Gandy, Stephen. AU - Lang, Stephen. AU - Zhang, Yilong. AU - Huang, Zhihong. AU - Nabi, Ghulam. PY - 2018/3/23. Y1 - 2018/3/23. N2 - Objectives: to assess the diagnostic accuracy of quantitative parameters of DCE-MRI in multi-parametric MRI (mpMRI) in comparison to the histopathology (including Gleason grade) of prostate cancer.Patients and methods: 150 men with suspected prostate cancer (abnormal digital rectum examination and or elevated prostate-specific antigen) received pre-biopsy 3T mpMRI and were recruited into peer-reviewed, protocol-based prospective study. The DCE-MRI quantitative parameters (Ktrans (influx transfer constant) and kep (efflux rate constant)) of the cancerous and normal areas were recorded using four different kinetic models employing Olea Sphere ...
Dynamic Contrast-Enhanced Magnetic Resonance Imaging As a Biomarker for the Pharmacological Response of PTK787/ZK 222584, an Inhibitor of the Vascular Endothelial Growth Factor Receptor Tyrosine Kinases, in Patients With Advanced Colorectal Cancer and Liver Metastases: Results From Two Phase I ...
Optimized Fast Dynamic Contrast-Enhanced Magnetic Resonance Imaging of the Prostate Effect of Sampling Duration on Pharmacokinetic ...
Material and method Two intracranial stents (Enterprise and Helistent) were placed in polyvinyl chloride tubes as vascular phantoms. They were filled with six different doses of gadolinium contrast agent (1.0, 2.0, 4.0, 6.0, 8.0, and 10.0 mmol/L dimeglumine gadopentetate, respectively) and imaged using 3 T and 1.5 T MR systems. Relative in-stent signal (RIS) was calculated and artificial luminal narrowing (ALN) was obtained using pixel by pixel analysis. ...
TY - JOUR. T1 - Dynamic contrast-enhanced MRI in oncology: how we do it. T2 - Radiologia Medica. AU - Petralia, G.. AU - Summers, P.E.. AU - Agostini, A.. AU - Ambrosini, R.. AU - Cianci, R.. AU - Cristel, G.. AU - Calistri, L.. AU - Colagrande, S.. N1 - Export Date: 4 March 2021 CODEN: RAMEA Correspondence Address: Colagrande, S.; Struttura Complessa di Radiodiagnostica Universitaria (SOD 2), Largo Brambilla 3, Italy; email: [email protected] Chemicals/CAS: Contrast Media References: Hanahan, D., Weinberg, R., The hallmarks of cancer (2000) Cell, 144 (5), pp. 646-674; Radue, E.W., Kendall, B.E., Xenon enhancement in tumours and infarcts (1978) Neuroradiology, 16, pp. 224-227. , COI: 1:STN:280:DyaE1M7hsVykuw%3D%3D; Cherry, S.R., Carnochan, P., Babich, J.W., Serafini, F., Rowell, N.P., Watson, I.A., Quantitative in vivo measurements of tumor perfusion using rubidium-81 and positron emission tomography (1990) J Nucl Med, 31 (8), pp. 1307-1315. , COI: 1:CAS:528:DyaK3cXls1yiurg%3D, PID: ...
In recent years, there have been a number of studies comparing different gadolinium chelates for MR imaging of tumors, particularly for MR imaging of intracranial neoplasms. These have included intraindividual studies that compared gadobenate dimeglumine (MultiHance; Bracco, Milan, Italy) with other gadolinium agents1-3 for imaging cerebral tumors, and a study similar to that of Kim et al4 that compared gadobutrol (Gadovist; Bayer Schering Pharma, Berlin, Germany) with gadopentetate dimeglumine (Magnevist; Bayer Schering Pharma) for imaging of cerebral metastasis.5. Studies comparing gadobenate dimeglumine with other gadolinium chelates have demonstrated the superiority of this agent in terms of contrast enhancement and lesion characterization, delineation, extension, and definition of internal structures at 1.5T and 3T. Lesions included were mostly intracranial tumors, with the highest percentage being intraparenchymal gliomas. Although detailed evaluation of different histologic types has yet ...
Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma Academic Article ...
My GP was very understanding and initially only requested me to begin taking folic acid, and we discussed decreasing my meds. LH helps the theca cells gadolinium contrast and pregnancy the ovaries that provide androgens and hormonal precursors for the production of estrogen. Sure, you may wear high heels (you learn it right, women!) however ensure you are a hundred percent comfortable in them. My first tip of attainable being pregnant was constipation (that by no pregnanvy happens to me) and the one dark brown spot on my undies. Ladies have different experiences with pregnancies. Attempt to profit from these few weeks contrasy than your baby is born. By using this form of calendar you can get a prediction of what sex a baby can be whether it is conceived by a gadolinium contrast and pregnancy of a sure age in a sure lunar month. It gadolinium contrast and pregnancy marked by a surge of feeling for the child, as also parenting and family literacy centres toronto anxiousness and larger sensitivity ...
Diffusely infiltrative form of aggressive intrasegmental recurrence of hepatocellular carcinoma with tumor thrombus formation (HCC) after radiofrequency ablation. (A) Gadoxetic acid-enhanced magnetic resonance image obtained during portal venous phase before RFA shows HCC (asterisk) in the bottom portion of segment VIII. HCC was diagnosed by percutaneous liver biopsy before treatment because arterial hypervascularization was equivocal. The index tumor was in broad contact with a small peritumoral portal vein (arrow). (B) Contrast-enhanced axial computed tomography (CT) scan obtained during portal venous phase 7 months after RFA shows neither local tumor progression around involution of the ablation zone (asterisk) nor intrahepatic distant recurrence. Adjacent portal veins appear patent, with no evidence of tumor thrombus (arrows). (C) CT scan obtained during hepatic arterial phase 24 months after RFA shows an ill-defined enhancing lesion with a diffusely infiltrative pattern (white arrows) in ...
Introduction: First-pass contrast enhanced myocardial perfusion MR imaging in rodents has so far not been possible due to the challenging temporal and spatial resolution requirements.. Hypothesis: New spatio-temporal undersampling schemes such as k-t SENSE permit the acquisition of first pass myocardial perfusion MR data in rodents on a clinical MR scanner and quantitative estimates of myocardial blood flow.. Methods: We developed a new first pass perfusion MR method for rodent imaging on a clinical 3.0 Tesla scanner (Philips Healthcare, Best, the Netherlands) that employed 10-fold k-space and time domain undersampling with constrained image reconstruction using temporal basis sets (k-t PCA) to achieve a spatial resolution of 0.2 × 0.2 × 1.5mm3 and an acquisition window of 43ms. The method was tested in 5 healthy and 4 infarct mice (C57BL/6J).. Results: Data were acquired successfully in all mice at heart rates of 495.1±45.8bpm. Signal-intensity-time profiles showed a percentage myocardial ...
Dynamic contrast-enhanced (DCE)-MRI is useful to assess the early effects of drugs acting on tumor vasculature, namely anti-angiogenic and vascular disrupting agents. Ultra-high-field MRI allows higher-resolution scanning for DCE-MRI while maintaining an adequate signal-to-noise ratio. However, increases in susceptibility effects, combined with decreases in longitudinal relaxivity of gadolinium-based contrast agents (GdCAs), make DCE-MRI more challenging at high field. The aim of this work was to explore the feasibility of using DCE-MRI at 11.7 T to assess the tumor hemodynamics of mice. Three GdCAs possessing different molecular weights (gadoterate: 560 Da, 0.29 mmol Gd/kg; p846: 3.5 kDa, 0.10 mmol Gd/kg; and p792: 6.47 kDa, 0.15 mmol Gd/kg) were compared to see the influence of the molecular weight in the highlight of the biologic effects induced by combretastatin A4 (CA4). Mice bearing transplantable liver tumor (TLT) hepatocarcinoma were divided into two groups (n = 5-6 per group and per ...
A method was devised for obtaining dynamic contrast-enhanced T1-weighted and relaxation rate (delta R2*) images simultaneously to evaluate regional hemodynamics of the brain tumors. On a 1.5-T MR system, dual dynamic contrast-enhanced images were obtained using a gradient echo (dual echo fast field …
title: Gadolinium-Enhanced Magnetic Resonance Imaging of Atherosclerotic Plaques in Comparison with Histopathology: An In Vivo Study in Aorta of Rabbits, doi: none, category: Article
Gadolinium has no large-scale applications, but it has a variety of specialized uses.. Because 157Gd has a high neutron cross-section, it is used to target tumors in neutron therapy. This element is effective for use with neutron radiography and in shielding of nuclear reactors. It is used as a secondary, emergency shut-down measure in some nuclear reactors, particularly of the CANDU reactor type.[4] Gadolinium is also used in nuclear marine propulsion systems as a burnable poison.. Gadolinium possesses unusual metallurgic properties, with as little as 1% of gadolinium improving the workability and resistance of iron, chromium, and related alloys to high temperatures and oxidation.. Gadolinium is paramagnetic at room temperature, with a ferromagnetic Curie point of 20 °C (68 °F).[6] Paramagnetic ions, such as gadolinium, enhance nuclear relaxation rates, making gadolinium useful for magnetic resonance imaging (MRI). Solutions of organic gadolinium complexes and gadolinium compounds are used as ...
Although some linear contrast agents appear to cause greater MRI signal changes than some macrocyclic agents, deposition of gadolinium â ¦ Emerging evidence has linked MRI signal changes in deep nuclei of the brain with repeated administration of gadolinium-based contrast agents. At least 60% of our subjects showed a glove-and-sock distribution of disease associated with intense sharp â pins and needlesâ or â ¦ In patients with kidney problems, the substance is not removed completely leading to an increased risk of Gadolinium deposition disease. The mechanism of NSF is â ¦ 2. An expansion of described symptoms for GDD. Gadolinium awareness. She had to be hospitalized repeatedly with debilitating pain. 2016; 34(10):1383-1390 (ISSN: 1873-5894) GDD or Gadolinium toxicity may include bone, skin and tissue pain, â brain fogâ and/or progressive thickening of the skin. Gadolinium Deposition Disease is a new diagnosis with no standard testing procedures or treatments. Gadolinium toxicity ...
Myocardial fibrosis imaging using late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) has been validated as a quantitative predictive marker for response to medical, surgical, and device therapy. To date, all such studies have examined conventional, non-phase corrected magnitude images. However, contemporary practice has rapdily adopted phase-corrected image reconstruction. We sought to investigate the existence of any systematic bias between threshold-based scar quantification performed on conventional magnitude inversion recovery (MIR) and matched phase sensitive inversion recovery (PSIR) images. In 80 patients with confirmed ischemic (N = 40), or non-ischemic (n = 40) myocardial fibrosis, and also in a healthy control cohort (N = 40) without fibrosis, myocardial late enhancement was quantified using a Signal Threshold Versus Reference Myocardium technique (STRM) at ≥2, ≥3, and ≥5 SD threshold, and also using the Full Width at Half Maximal (FWHM) technique. This was performed on
Myocardial fibrosis imaging using late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) has been validated as a quantitative predictive marker for response to medical, surgical, and device therapy. To date, all such studies have examined conventional, non-phase corrected magnitude images. However, contemporary practice has rapdily adopted phase-corrected image reconstruction. We sought to investigate the existence of any systematic bias between threshold-based scar quantification performed on conventional magnitude inversion recovery (MIR) and matched phase sensitive inversion recovery (PSIR) images. In 80 patients with confirmed ischemic (N = 40), or non-ischemic (n = 40) myocardial fibrosis, and also in a healthy control cohort (N = 40) without fibrosis, myocardial late enhancement was quantified using a Signal Threshold Versus Reference Myocardium technique (STRM) at ≥2, ≥3, and ≥5 SD threshold, and also using the Full Width at Half Maximal (FWHM) technique. This was performed on
Dynamic Contrast-Enhanced Magnetic is now established as the methodology of choice for the assessment of tumor microcirculation in vivo. The method assists
Purpose To evaluate the feasibility of ultrafast dynamic contrast-enhanced (UF-DCE) magnetic resonance imaging (MRI) with compressed sensing (CS) for the separate identification of breast arteries/veins and perform temporal evaluations of breast arteries and veins with a focus on the association with ipsilateral cancers. Materials and Methods Our Institutional Review Board approved this study with retrospective…
Background: Diffuse myocardial fibrosis (DF) in adults with aortic stenosis (AS) is associated with heart failure, arrhythmias, and mortality; however, little is known about its role in younger patients with congenital AS. Study aims were to apply for the first time a recently validated cardiac magnetic resonance (CMR) extracellular volume fraction (Vec) measurement technique to quantify DF in children and young adults with AS and to explore associations between DF and indices of diastolic function.. Methods: All pts who had a CMR with myocardial T1 measurement, were ,30 yrs, and had congenital AS with a peak Doppler gradient ≥20 mm Hg at any time prior to the CMR were included. The Vec, a measure of DF, was calculated in the mid-LV by measuring T1 values for blood pool and myocardium before and after gadolinium with a modified Look-Locker technique, and adjusting for hematocrit. Vec results were compared to published values in healthy volunteers (n=14).. Results: Thirty-five pts met inclusion ...
Wei Huang, Yiyi Chen, Andriy Fedorov, Xia Li, Guido H Jajamovich, Dariya I Malyarenko, Madhava P Aryal, Peter S LaViolette, Matthew J Oborski, Finbarr OSullivan, Richard G Abramson, Kourosh Jafari-Khouzani, Aneela Afzal, Alina Tudorica, Brendan Moloney, Sandeep N Gupta, Cecilia Besa, Jayashree Kalpathy-Cramer, James M Mountz, Charles M Laymon, Mark Muzi, Paul E Kinahan, Kathleen Schmainda, Yue Cao, Thomas L Chenevert, Bachir Taouli, Thomas E Yankeelov, Fiona Fennessy, and Xin Li. 2019.
TY - JOUR. T1 - Investigating tumor perfusion by hyperpolarized (13) C MRI with comparison to conventional gadolinium contrast-enhanced MRI and pathology in orthotopic human GBM xenografts. T2 - Correlation of13C Perfusion Imaging and Gd-Enhanced Contrast MRI. AU - Park, Ilwoo. AU - von Morze, Cornelius. AU - Lupo, Janine M. AU - Ardenkjær-Larsen, Jan Henrik. AU - Kadambi, Achuta. AU - Vigneron, Daniel B. AU - Nelson, Sarah J. PY - 2016. Y1 - 2016. N2 - Dissolution dynamic nuclear polarization (DNP) enables the acquisition of (13) C magnetic resonance data with a high sensitivity. Recently, metabolically inactive hyperpolarized (13) C-labeled compounds have shown to be potentially useful for perfusion imaging. The purpose of this study was to validate hyperpolarized perfusion imaging methods by comparing with conventional gadolinium (Gd)-based perfusion MRI techniques and pathology. Dynamic (13) C data using metabolically inactive hyperpolarized bis-1,1-(hydroxymethyl)-[1-(13) C]cyclopropane-d8 ...
Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης. Ιδρυματικό Καταθετήριο Επιστημονικών Εργασιών ΑΠΘ.Τμήμα περιοδικού.Επιστημονικό άρθρο.2016 . Creators: Efthymiadis, Georgios, Karvounis, Charalampos, Gossios, Thomas D., Zegkos, Thomas, Karamitsos, Theodoros, Athyros, Vasileios.Hypertrophic cardiomyopathy, the most common inherited cardiomyopathy is well known to be the leading cause of sudden cardiac death in young people. However, amongst the population of patients, a small subset bears increased risk of sudden cardiac death and would benefit from implantation of a defibrillator, currently recognized utilizing a series of established risk factors. This risk stratification model is hampered by low positive predictive value. Therefore, novel predictors of sudden death are sought. The advent of cardiac magnetic resonance and late gadolinium enhancement has allowed accurate quantification
The Gadolinium Nitrate market is anticipated to record a global CAGR of AAA% during the forecast period of 2019 2025. North America, SEA & Others of APAC and Eastern Europe regions are expected to account for an estimated market share of xx% by the end of the forecast period.. AMR addresses key insights on the Gadolinium Nitrate market in its report titled Gadolinium Nitrate Among the segments of the Gadolinium Nitrates market, software components are expected to register the biggest growth in the Gadolinium Nitrate market.. The global Gadolinium Nitrate market size is estimated at xxx million USD with a CAGR xx% from 2016-2020 and is expected to reach xxx Million USD in 2021 with a CAGR xx% from 2021 to 2026. The report begins from overview of Industry Chain structure, and describes industry environment, then analyses market size and forecast of Gadolinium Nitrate by product, region and application, in addition, this report introduces market competition situation among the vendors and company ...
To evaluate the usefulness of dynamic MRI of kidneys in healthy volunteers and patients with different 24-hour creatinine clearance (Ccr) levels, a dynamic study that employed the T2* weighted gradient echo technique (FLASH : TR/TE=34/25msec,flip angle=20 degrees) with single images during breathhold was performed on 10 healthy volunteers and 35 patients, all examined for the Ccr and suspected of having renal parenchmal disease after a phantom study. T1-weighted and dynamic MR imagings were obtained with a 1.5T imager.I andalyzed the time-intensity curve of renal cortex and medulla, and defined a cortex decreased ratio (CDR) and medulla decreased ratio (MDR) in comparison with the Ccr. The cortico-medullary difference ratio (CMDR) of T1WI were better correlated with the Cce. The parameters of the T2* dynamic MRI study (CDR, MDR) were better correlated with the Ccr than CMDR. Renal function can be quantitatively evaluated with the T2* dynamic MRI and there ia s possibility that we can ...
We describe here in a large group of patients qualitative and semiquantitative DCE-MRI parameters that distinguish sMM from normal controls. We also provide evidence that this technique can identify a distinct patient population in NRC that presents with a pathologic DCE-MRI. Referring to this, pathologic findings according to our analysis were defined by a pattern of strongly increased microcirculation (diffuse variant), focal hotspots in the investigated area (focal pattern), or by an amplitude A above the upper limit of normal controls. It has to be mentioned that a diffuse variant pattern cannot be distinguished from a focal pattern affecting the whole vertebra, which may explain in part why those two patterns seem to seem exclusively in the same, namely the symptomatic patient group.. Different patterns of bone marrow involvement of MM in conventional as well as DCE-MRI have been described concordantly by different authors (14, 23, 29, 30). Diffuse distribution of microcirculation was found ...
Gadolinium chelate administration is largely unnecessary for imaging pediatric tumors when performing MRI or combined PET/MR scans, according to a recent study published by the Journal of Nuclear Medicine.. Heike E. Daldrup-Link, MD, PhD, Stanford School of Medicine, and colleagues compared the accuracy of gadolinium chelate-enhanced and unenhanced MR images of 119 pediatric patients. They also compared the accuracy of gadolinium chelate-enhanced and unenhanced 18F-FDG PET/MR images for 36 pediatric patients.. Overall, the researchers found that gadolinium chelate administration made no significant difference in the diagnostic accuracy of MR or 18F-FDG PET/MR images of pediatric tumors. Read more.. ...
The improved algorithms presented should be useful when the AIF and tissue response are sparsely sampled. The noniterative approach may be suitable for semiquantitative visualization, or where the AIF and tissue response are sampled accurately and with a small time interval between samples.
https://doi.org/10.18632/oncotarget.24652 Cheng Wei, Bowen Jin, Magdalena Szewczyk-Bieda, Stephen Gandy, Stephen Lang, Yilong Zhang, Zhihong Huang, Ghulam Nabi
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The goal of this predoctoral fellowship research project is to improve the temporal and spatial resolutions in dynamic contrast-enhanced magnetic resonance imaging of the breast. Specifically, we investigated the use of non-Fourier encoding for collecting the reduced encoding dynamic data sets. The conclusion from our study was that the current wavelet and SVD encoding methods do not achieve the desired goal of exploiting the desirable truncation properties of these basis functions and, at times, can introduce dangerous artifacts. For Fourier-encoded data, the Reduced-encoding Imaging by Generalized-series Reconstruction (RIGR) method was shown to be a better way to extrapolate the unmeasured dynamic data using a priori constraints than Fourier-keyhole. Next, we further optimized the basis functions of the generalized-series (GS) model used by the RIGR algorithm. The Two-reference RIGR (TRIGR) method resulted from suppressing background information in the GS basis functions, enabling them to better
TY - CONF. T1 - Suppression of acid reflux with double-dose Esomeprazole for 6 months does not alter DNA methylation in patients with Barretts Esophagus. AU - Smith, Eric. AU - Drew, Paul. AU - Abu-Sneineh, Awni. AU - Tam, William. AU - Ruszkiewicz, Andrew. AU - Schoeman, Mark. AU - Dent, John. AU - Holloway, Richard. PY - 2006. Y1 - 2006. M3 - Paper. T2 - 107th Annual Meeting of the American Gastroenterological Association Institute. Y2 - 20 May 2006. ER - ...
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We read with great interest the article by Jablonowski et al. (1) showing that contrast-enhanced cardiac magnetic resonance (ce-CMR) overestimates infarct size at 6 h post-reperfusion compared with pathology and that infarct imaging timing by ce-CMR is critical. Although this is not an entirely new finding, the careful and meticulous work performed by the authors demonstrates the rapidly changing nature of acute infarction and reperfused myocardial tissue (2). If this experimental work focuses precisely on infarct sizing, the reader is left with several open questions.. On observation of the different figures from this article (Figures 3 and 6), there is a 50% reduction of infarct size by ce-CMR, whereas there is a 26% increase in myocardial salvage and a 30% reduction in extracellular volume by pathology in the infarcted myocardium and adjacent areas between day 0 and day 7. In this rapid series of myocardial tissue changes, it is hard for the reader to understand that the same changes do not ...
Are Gadolinium Dye For Mri Contrast Side Effects Putting Your Health at Risk? | Jul 09, 2017 Check these Gadolinium Dye For Mri Contrast side effect reports: A 46-year-old female patient was diagnosed with NA, treated with GADOLINIUM DYE FOR MRI CONTRAST and reported cardio-respiratory arrest,flushing,obstructive airways disorder. Dosage: . Patient was hospitalized.
Purpose Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) provides an advantage over conventional MRI in that DCE-MRI provides anatomical, physiological, and hemodynamic information about neoplastic lesions. Our aim in this study was to evaluate spinal metastases from hypervascular renal cell carcinoma (RCC) and hypovascular prostate carcinoma (PC) using a T1 DCE-MRI perfusion technique and to assess the sensitivity and specificity of the perfusion parameters obtained. Materials & Methods A total of 40 patients with spinal metastases and either PC or RCC as the primary tumor were studied. DCE perfusion parameters-vascular permeability (Ktrans), plasma volume (Vp), wash-in, and peak-enhancement were measured to assess their potential as discriminators of tumor histology. A Mann-Whitney U test, at a significance level of p≤0.01, was performed to quantify and compare the significances of the perfusion parameters of PC and those of RCC. Results Of the four perfusion parameters ...
As with most medical conditions, the specific symptoms of Gadolinium Toxicity will vary from person to person. Other than what you will read here and in our research papers, there is no published listing of the common symptoms of Gadolinium Toxicity. By means of a symptom survey of 17 people with high urine levels of Gadolinium, we have…
Weinmann HJ, Brasch RC, Press WR, Wesbey GE (March 1984). "Characteristics of gadolinium-DTPA complex: a potential NMR contrast ... Most commonly, a paramagnetic contrast agent (usually a gadolinium compound) is given. Gadolinium-enhanced tissues and fluids ... MRI contrast agents, such as those containing Gadolinium(III) work by altering (shortening) the relaxation parameters, ... There have been concerns raised recently regarding the toxicity of gadolinium-based contrast agents and their impact on persons ...
Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1 relaxation time ( ... Gadolinium is highly toxic and the accumulation of gadolinium in the brain has become a concern. The EU has banned linear ... Compared to other gadolinium-based MRI contrast agents, Gadopentetate dimeglumine (Gd-DTPA2-) chelates allow delayed Gadolinium ... dtpa_05m_injection Murphy KJ, Brunberg JA, Cohan RH (1996). "Adverse reactions to gadolinium contrast media: a review of 36 ...
"Initial clinical evaluation of gadolinium DTPA for contrast-enhanced magnetic resonance imaging". Magnetic Resonance Imaging. 3 ... Runge was one of the early researchers to investigate the use of gadolinium-based contrast agents for magnetic resonance ... This identifies a pathway by which linear gadolinium chelates may produce ill effects in otherwise normal patients long after ... In 2019, under his guidance, the first study demonstrating the toxicity of gadolinium chelates to brain tissue was published. ...
DTPA is also used as a complexing agent for gadolinium in MRI contrast enhancement. The requirement in this case is that the ... Ligands such as DTPA, which have eight donor atoms are used to form complexes with large metal ions such as lanthanide or ... In addition the ligand occupies only 8 of the 9 coordination sites on the gadolinium ion. The ninth site is occupied by a water ... Excess copper in Wilson's disease can be removed by penicillamine or Triethylene tetramine (TETA). DTPA has been approved by ...
... and the gadolinium complexes often employ the usage of octadentate ligands such as DTPA, according to Desreux et al. Auranofin ... Chelate complexes of gadolinium are often used as contrast agents in MRI scans, although iron particle and manganese chelate ... Caravan P, Ellison JJ, McMurry TJ, Lauffer RB (September 1999). "Gadolinium(III) Chelates as MRI Contrast Agents: Structure, ...
Scar is best seen after giving a contrast agent, typically one containing gadolinium bound to DTPA. With a special sequence, ... CMR in the 4 chamber view comparing the cine (left) with the late gadolinium image using inversion recovery (right). The ...
Several polymeric gadolinium-based BPAs are currently in development but have not yet been approved for clinical use: ... Gadocoletic acid (Bracco SpA), also known as B-22956 and B22956/1, is a Gd-DTPA derivative that is currently in development, ... also known as Gd-DTPA-17, SH L 643 A. "MR Contrast Agents". 2014. Blood Pool Agents Geraldes CF, Laurent S, Classification and ...
Second, gadolinium compounds, such as Gd-DTPA (gadopentetate dimeglumine Magnevist®), have been used routinely as contrast ... Nemoto, H.; Cai, J.; Nakamura, H.; Fujiwara, M.; Yamamoto, Y. (1999). "The synthesis of a carborane gadolinium-DTPA complex for ... 2006). "Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nuclei". Clinical Cancer Research. 12 (1): ... There also has been interest in the possible use of gadolinium-157 (157Gd) as a capture agent for NCT for the following reasons ...
... diethylenetriaminepentaacetic acid gadolinium (III) dihydrogen salt hydrate (Gd-DTPA). Like most cells, these breast cancer ... cells are much more weakly attracted by magnets than Gd-DTPA, which is an FDA-approved MRI contrast agent for use in humans. ...
Additionally, DTPA is used in MRI contrasting agents. DTPA improves MRI images by forming a complex with a gadolinium ion, ... Pentetreotide is a modified DTPA attached to a peptide segment. DTPA and derivatives are used to chelate gadolinium to form a ... The recommended treatment is for an initial dose of calcium-DTPA, as this salt of DTPA has been shown to be more effective in ... After that time has elapsed both calcium-DTPA and zinc-DTPA are similarly effective in reducing internal contamination with ...
The structure of [Gd(DTPA)(H2O)]2− is a distorted tricapped trigonal prism. The following is the reaction for the formation of ... Gadolinium(III) chloride, also known as gadolinium trichloride, is GdCl3. It is a colorless, hygroscopic, water-soluble solid. ... "Gadolinium". Magnetic Resonance TIP-MRI Database. Retrieved February 22, 2006. "Gadolinium". Webelements. Retrieved February 22 ... C from gadolinium oxide: 10 NH4Cl + Gd2O3 → 2 (NH4)2[GdCl5] + 6 NH3 + 3 H2O from hydrated gadolinium chloride: 4 NH4Cl + 2 ...
DTPA)(2-)-enhanced MR imaging". Radiology. 205 (2): 551-8. doi:10.1148/radiology.205.2.9356644. PMID 9356644. Siversson, C; ... Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative ... Transplants with 3-T Delayed Gadolinium-Enhanced MRI of Cartilage Association between findings on delayed gadolinium-enhanced ... Preliminary Results Glycosaminoglycan Distribution in Cartilage as Determined by Delayed Gadolinium-Enhanced MRI of Cartilage ( ...
Inspired by a colleague's work in cardiac imaging, Gray worked with them and developed Delayed gadolinium-enhanced magnetic ... DTPA)(2-)-enhanced MR imaging". Radiology. 205 (2): 551-558. doi:10.1148/radiology.205.2.9356644. ISSN 0033-8419. PMID 9356644 ...
Interaction with the gadolinium (Gd) contrast agent (commonly a gadolinium ion chelate) causes the relaxation time of water ... Tofts, PS; Buckley, DL (1997). "Modeling tracer kinetics in dynamic Gd-DTPA MR imaging". Journal of Magnetic Resonance Imaging ... The common procedure for a DCE-MRI exam is to acquire a regular T1-weighted MRI scan (with no gadolinium), and then gadolinium ... Pharmacokinetic modelling of gadolinium in DCE-MRI is complex and requires choosing a model. There are a variety of models, ...
... motexafin gadolinium - moxifloxacin - MPNST - MRI - MRSI - MS 209 - MS-275 - mucinous carcinoma - mucosa-associated lymphoid ... tin Sn 117m DTPA - tinidazole - tioguanine - tipifarnib - tirapazamine - tissue plasminogen activator - TLK286 - TM - ...
Second, gadolinium compounds, such as Gd-DTPA (gadopentetate dimeglumine Magnevist®), have been used routinely as contrast ... Gadolinium neutron capture therapy (Gd NCT)Edit. There also has been interest in the possible use of gadolinium-157 (157Gd) as ... Nemoto, H.; Cai, J.; Nakamura, H.; Fujiwara, M.; Yamamoto, Y. (1999). "The synthesis of a carborane gadolinium-DTPA complex for ... 2006). "Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nuclei". Clinical Cancer Research. 12 (1): ...
... before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). Precontrast studies included a comprehensive protocol ... before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). Precontrast studies included a comprehensive protocol ... Brain tumors: MR imaging with gadolinium-DTPA Radiology. 1985 Sep;156(3):681-8. doi: 10.1148/radiology.156.3.4040643. ... After administration of Gd-DTPA (0.1 mmol/kg), increased signal intensity from the tumor was observed in all patients. The ...
Brain tumors: MR imaging with gadolinium-DTPA.. Felix R, Schörner W, Laniado M, Niendorf HP, Claussen C, Fiegler W, Speck U. ... before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). Precontrast studies included a comprehensive protocol ... After administration of Gd-DTPA (0.1 mmol/kg), increased signal intensity from the tumor was observed in all patients. The ... glioblastomas and intracranial metastases required Gd-DTPA administration for diagnostically sufficient tumor display. ...
Gd-DTPA) is a potential clinical magnetic resonance (MR) contrast agent that enhances images primarily by decreasing spin- ... Gadolinium-DTPA complex (Gd-DTPA) is a potential clinical magnetic resonance (MR) contrast agent that enhances images primarily ... Tissue distribution and magnetic resonance spin lattice relaxation effects of gadolinium-DTPA Radiology. 1985 Mar;154(3):723-6. ... An intravenous bolus of Gd-DTPA with a tracer quantity of Gd-153 was administered to three groups of rabbits at the following ...
To define the time course and mechanism of enhancement of epidural fibrosis after gadolinium-DTPA (Gd-DTPA) injection, we ... Gadolinium-DTPA-Enhanced MR Imaging of the Postoperative Lumbar Spine: Time Course and Mechanism of Enhancement. Jeffrey S. ... Gadolinium-DTPA-Enhanced MR Imaging of the Postoperative Lumbar Spine: Time Course and Mechanism of Enhancement ... Gadolinium-DTPA-Enhanced MR Imaging of the Postoperative Lumbar Spine: Time Course and Mechanism of Enhancement ...
Gadolinium-Ethoxybenzyl-DTPA, a new liver specific MR contrast agent : kinetic and enhancement patterns in normal and ... Gadolinium-Ethoxybenzyl-DTPA, a new liver specific MR contrast agent : kinetic and enhancement patterns in normal and ... Gadolinium-Ethoxybenzyl-DTPA, a new liver specific MR contrast agent : kinetic and enhancement patterns in normal and ...
A pharmacokinetic and MRI study of unilamellar gadolinium-, manganese-, and iron-DTPA-stearate liposomes as organ-specific ... A pharmacokinetic and MRI study of unilamellar gadolinium-, manganese-, and iron-DTPA-stearate liposomes as organ-specific ... Small unilamellar liposomes that contain the lipophilic chelate DTPA-stearate (DTPASA) were used as carriers for the ... Small unilamellar liposomes that contain the lipophilic chelate DTPA-stearate (DTPASA) were used as carriers for the ...
Gadolinium-DTPA Enhanced Dynamic MR Imaging in the Evaluation of Cisplatinum Nephrotoxicity. Frank, Joseph A.; Choyke, Peter L ... Three-dimensional FLASH Imaging: Applications with Gadolinium-DTPA. Ross, Jeffrey S.; Masaryk, Thomas J.; Modic, Michael T. ... Gadolinium-DOTA Enhanced MR Imaging of Intracranial Lesions. Parizel, Paul M.; Degryse, Hendrik R.; Gheuens, Jan; More ...
55 BIOLOGY AND MEDICINE, BASIC STUDIES; SINUSES; NMR IMAGING; ADENOMAS; HISTOLOGY; PITUITARY GLAND; GADOLINIUM COMPLEXES; DTPA ... Type I showed a gadolinium-enhanced stripe medial to the carotid artery (5 patients), none of which showed dural invasion. Type ... Type I showed a gadolinium-enhanced stripe medial to the carotid artery (5 patients), none of which showed dural invasion. Type ...
MRI detection of myocardial perfusion changes by gadoliniumDTPA infusion during dipyridamole hyperemia. / Miller, D. Douglas; ... Fingerprint Dive into the research topics of MRI detection of myocardial perfusion changes by gadoliniumDTPA infusion during ... MRI detection of myocardial perfusion changes by gadoliniumDTPA infusion during dipyridamole hyperemia. Magnetic Resonance in ... title = "MRI detection of myocardial perfusion changes by gadoliniumDTPA infusion during dipyridamole hyperemia", ...
Gadolinium DTPA. LinkOut - more resources. Full Text Sources. *Atypon - PDF. Medical. *Brain Aneurysm - MedlinePlus Health ... Follow-up of intracranial aneurysms treated with detachable coils: comparison of gadolinium-enhanced 3D time-of-flight MR ...
Have any contra-indications to magnetic resonance (MR) examination such as allergy to MRI contrast media (gadolinium-DTPA [ ... Patients then undergo MRI and gadopentetate dimeglumine (Gd-diethylenetriamine penta-acetic acid [DTPA]) perfusion imaging ...
As a first representative of this family of substances, the dimeglumine salt of the Gd DTPA (gadolinium(III) complex of ... The invention relates to new diethylenetriaminepentaacetic acid (DTPA) monoamides, DTPA monoamide complexes and complex salts, ... After adding 3.22 g of monohydrate of the calcium trisodium salt of the DTPA, CaNa3 DTPA and 1.21 g of ... Diamide-DTPA-paramagnetic contrast agents for MR imaging. US4826673 *. Jan 9, 1985. May 2, 1989. Mallinckrodt, Inc.. Methods ...
Gadolinium-DTPA-BMA. *Gd-DTPA-BMA. *HSDB 7547. *OmniScan. Procedure: Multiparametric Magnetic Resonance Imaging Undergo ... Known contraindication to intravenous gadolinium contrast administration (e.g., renal impairment, known allergy); standard ... institutional policies on gadolinium and renal function will be followed. *Contraindication to placement of endorectal MRI coil ...
Gadolinium-diethyleneaminepentaacetate (Gd-DTPA) is administered intravenously, and following a waiting period of 10 or more ... gadolinium-diethyleneaminepentaacetate (Gd-DTPA); phosphocreatine (PCr); inorganic phosphate (Pi); tricarboxylic acid (TCA); ... The inversion time is chosen based on the blood concentration of Gd-DTPA (21) in order to reduce myocardial intensity to a low ... Myocardial Gd-DTPA kinetics determine MRI contrast enhancement and reflect the extent and severity of myocardial injury after ...
Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T. / Hill, B. J.; Padgett, K. R. ... Hill, BJ, Padgett, KR, Kalra, V, Marcillo, A, Bowen, B, Pattany, P, Dietrich, D & Quencer, R 2018, Gadolinium DTPA enhancement ... Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T. American Journal of ... title = "Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T", ...
Magnetic Resonance Imaging (MRI) with intravenous Gadolinium-DTPA (Gd-DTPA, Magnevist, Schering-AG) was performed in 44 ... Magnetic Resonance Imaging (MRI) with intravenous Gadolinium-DTPA (Gd-DTPA, Magnevist, Schering-AG) was performed in 44 ... Magnetic resonance imaging with Gadolinium-DTPA for assessment of bladder carcinoma and its response to treatment.. Authors:. ... Magnetic resonance imaging with Gadolinium-DTPA for assessment of bladder carcinoma and its response to treatment.. en. ...
In the first session, we obtained one scan 5 to 7 minutes after the injection of 0.1 mmol/kg gadolinium-DTPA (standard dose). ... Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS ... These data indicate that in patients with MS, a triple dose of gadolinium-DTPA can reveal many more enhancing lesions, which ... We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity of ...
Gadolinium DTPA • Humans • Magnetic Resonance Imaging • Male • Middle Aged • Retrospective Studies • Sensitivity and ... Administration of intraarticular gadolinium enhances the MRI appearance of the labrum to improve detection of labral ...
Gadolinium complex. Gd-DTPA-BMA. Gd-DO3A. Gd-DOTMA. Crystal dimensions (mm). 0.20 × 0.10 × 0.04. 0.16 × 0.07 × 0.03. 0.15 × ... The three gadolinium complexes giving the best results with urate oxidase, Gd-DTPA-BMA, Gd-DO3A and Gd-DOTMA, were also tested ... 12 e−) of gadolinium with Cu Kα radiation, or with synchrotron radiation at the peak of the gadolinium LIII absorption edge, ... DTPA and DTPA-BMA are acyclic ligands. When the ligand molecules chelate the Gd3+ ion, their carboxylic groups are deprotonated ...
DAA, direct-acting antiviral; Gd-EOB-DTPA, gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid; HCC, hepatocellular ... detected by gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging to typical HCC ...
Initial experiences with a gadolinium-DTPA-based aerosol. Invest Radiol 32:797-801PubMedGoogle Scholar ... Montgomery AB, Paajanen H, Brasch RC, Murray JF (1987) Aerosolized gadolinium-DTPA enhances the magnetic resonance signal of ... Aerosoliertes Gadolinium-DTPA zur Darstellung der Lungenventilation in der Magnetresonanztomographie. Rofo 172:323-328PubMed ... Mechanical delivery of aerosolized gadolinium-DTPA for pulmonary ventilation assessment in MR imaging. Invest Radiol 36:240-243 ...
... were performed before and after application of gadolinium diethylenetriaminepentaacetic acid (T1/Gd-DTPA). The evaluation of ... Inflammatory spinal lesions were quantified by the ASspiMRI-a rating gadolinium-enhanced (T1-weighted gadolinium ... T1/Gd-DTPA = T1-weighted gadolinium diethylenetriaminepentaacetic acid. ... For the assessment of spinal lesions, vertebral units were evaluated by one reader (XB) using the T1/Gd-DTPA and STIR MRI ...
Gadolinium DTPA. - IV contrast medium, causes changes in local magnetic field and alters tissue signal. - Vascular lesion and ...
gadolinium-diethylenetriamine pentaacetic acid. Abbreviation: Gd-DTPA. A radiographic contrast agent, used in magnetic ... Contrast agents containing gadolinium should not be given to patients with diminished renal function. CAS # 86050-77-3 ...
Iwata and colleagues found that a region of the basal ganglia enhanced with gadolinium-DTPA (Gd-DTPA) before the onset of ... Magnetic resonance (MR) brain imaging with intravenous gadolinium (Gd) diethylenetriamine pentaacetic acid (Gd-DTPA) was used ... The T1W image before Gd-DTPA was subtracted from the images at each time point after Gd-DTPA. Net signal intensity was plotted ... Signal change after Gd-DTPA injection. Signal change in blood after Gd-DTPA injection. In the left and right internal carotid ...
Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients. Am J Roentgenol. 1984;143:215-224. ... Magnetic resonance imaging of the pancreas with gadolinium-DTPA. Abdom Imaging. 1991;16:139-142.Google Scholar ... Extracellular gadolinium-based contrast media: differences in diagnostic efficacy. Eur J Radiol. 2008;66:168-174.PubMedCrossRef ... Hepatobiliary MR imaging with gadolinium-based contrast agents. J Magn Reson Imaging. 2012;35:492-511.PubMedPubMedCentral ...
EVALUATION OF RESIDUAL ACOUSTIC SCHWANNOMA USING GADOLINIUM-DTPA ENHANCED MAGNETIC RESONANCE IMAGING WITH THE FAT SUPPRESSION ...
0 (Contrast Media); K2I13DR72L (Gadolinium DTPA). [Em] M s de entrada:. 1801. ... Gadol nio DTPA/administra o & dosagem. Seres Humanos. Modelos Log sticos. Masculino. Meia-Idade. An lise Multivariada. Fen meno ...
We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic ... Gadolinium DTPA / diagnostic use*, metabolism. Magnetic Resonance Imaging / methods*. Mice. Mice, Inbred C57BL. Microscopy, ... We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic ... Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted ...
Gadolinium DTPA / pharmacokinetics. Magnetic Resonance Imaging / methods. Myometrium / drug effects, physiopathology. Papio ... 0/Central Nervous System Depressants; 0/Contrast Media; 122795-43-1/gadodiamide; 3K9958V90M/Ethanol; K2I13DR72L/Gadolinium DTPA ...
  • Magnetic resonance (MR) brain imaging with intravenous gadolinium (Gd) diethylenetriamine pentaacetic acid (Gd-DTPA) was used to identify increased BBB permeability. (bmj.com)
  • We synthesized a novel fluorescein isothiocyanate-labeled gadolinium-diethylenetriamine pentaacetic acid (DTPA) conjugate in which the commonly used gadolinium-DTPA complex is flanked by the nuclear localization sequences of the simian virus-40 T antigen and the acute lymphatic leukemia-1 (ALL-1) protein. (aspetjournals.org)
  • The gadolinium-diethylenetriamine pentaacetic acid (Gd-DTPA) complex, which is commonly used in routine clinical magnetic resonance imaging (MRI), is restricted to the extracellular space and cannot reach the cell nucleus. (aspetjournals.org)
  • Evaluation of liver function using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid. (deepdyve.com)
  • Hayashi, Ryuichi 2018-06-02 00:00:00 Background Magnetic resonance imaging with gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (EOB-MRI) is a diagnostic modality for liver tumors. (deepdyve.com)
  • Keywords Magnetic resonance imaging Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid Three-dimensional volumetric analysis system Liver function Liver steatosis Introduction After major hepatectomy, the reported incidence of liver Electronic supplementary material The online version of this failure is 3-8%, and the reported rate of mortality associ- article (https://doi.org/10.1007/s12072-018-9874-x) contains ated with liver failure is approximately 5% [1]. (deepdyve.com)
  • Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) tends to show higher diagnostic accuracy than other modalities. (bioportfolio.com)
  • Inflammatory spinal lesions were quantified by the ASspiMRI-a rating gadolinium-enhanced (T1-weighted gadolinium diethylenetriaminepentaacetic acid) and STIR MRI sequences. (wiley.com)
  • Patients then undergo MRI and gadopentetate dimeglumine (Gd-diethylenetriamine penta-acetic acid [DTPA]) perfusion imaging immediately after exercise and after a 6-8 minute recovery period. (clinicaltrials.gov)
  • 9. A method according to claim 1, wherein said compound is a gadolinium complex of 3,6-bis(carboxymethyl)-9-(10-carboxydecylcarbamoylmethyl)-3,6,9-triazaundecanedioic acid. (google.com)
  • Gadobenic acid Gadoxetic acid https://www.ema.europa.eu/documents/psusa/gadopentetic-acid-list-nationally-authorised-medicinal-products-psusa/00001504/202004_en.pdf https://patents.google.com/patent/US5021236 http://www.isorad.co.il/en/products/gadolinium_gd_dtpa_05m_injection Murphy KJ, Brunberg JA, Cohan RH (1996). (wikipedia.org)
  • Dynamic MRI was performed using a multi-slice ultra-fast hybrid sequence and a rapid gadolinium-diethylenetriaminepenta-acetic acid bolus injection (0.05 mmol/l). (onlinejacc.org)
  • Finally, a subgroup of all 112 patients who Gadolinium ethoxybenzyl diethylenetriamine pen- underwent liver resection was used to analyze the corre- taacetic acid (Gd-EOB-DTPA) is a liver-specific magnetic lations between the LSR and histological parameters (pa- resonance imaging (MRI) contrast agent. (deepdyve.com)
  • Aim: To examine if it is possible to shorten the examination time of gadolinium ethoxybenzyl diethylenetriaminepentaacetic acid (Gd-EOB)-enhanced MRI by omitting hepatocyte-phase images of 20-min delay time (Im-20) for detecting focal liver lesions. (springermedizin.de)
  • Small unilamellar liposomes that contain the lipophilic chelate DTPA-stearate (DTPASA) were used as carriers for the paramagnetic metal ions gadolinium, manganese, and iron. (uzh.ch)
  • Molecular MRI of acute necrosis with a novel DNA-binding gadolinium chelate: kinetics of cell death and clearance in infarcted myocardium. (biomedsearch.com)
  • We report the use of a novel DNA-binding gadolinium chelate (Gd-TO) to specifically detect the exposed DNA in acutely necrotic (ruptured) cells in vivo. (biomedsearch.com)
  • In this study, dendrimers containing DTPA derivatives as cores and/or branching units were used to chelate gadolinium ions. (hindawi.com)
  • It is recommended that a different class of gadolinium chelate be used in these patients rather than the one that had caused the allergic reaction. (appliedradiology.com)
  • Is there a causal relation between the administration of gadolinium-based contrast media and the development of nephrogenic systemic fibrosis (NSF)? (wikipedia.org)
  • Conclusions The incidence of acute adverse reactions after administration of gadolinium-based contrast in the "off-label" setting of CMR in our population was not different from the incidence in the U.S. Food and Drug Administration-approved general radiology setting. (onlinejacc.org)
  • Focal liver disease: comparison of dynamic contrast-enhanced CT and T2-weighted fat-suppressed, FLASH, and dynamic gadolinium-enhanced MR imaging at 1.5 T. Radiology . (springer.com)
  • Gadolinium-based contrast agents are considered generally safe in radiology practice. (onlinejacc.org)
  • abstract = "To detect abnormal regional myocardial coronary flow reserve, serial spin‐echo MR tomograms of four control dogs and six with a partial balloon occlusion of the left anterior descending (LAD) coronary artery were acquired before and after dipyridamole infusion and during the paramagnetic effect of a bolus plus infusion of gadolinium‐DTPA. (elsevier.com)
  • Locating the gadolinium ions inside the dendrimers results in higher relaxivity constants, possibly because the paramagnetic center is closer to the rotational axis of the macromolecule. (hindawi.com)
  • These findings could contribute to the development of more effective contrast agents, either by placing the paramagnetic gadolinium ion in a strategic position or through functionalization of the dendron surface. (hindawi.com)
  • Gadolinium is a paramagnetic material which can shorten the T1 relaxation time of living tissues. (frontiersin.org)
  • The gadolinium ion has 7 unpaired electrons with parallel spins and is strongly paramagnetic with an 8S electronic ground state. (wikipedia.org)
  • We conclude that because of its extracellular distribution and linear relaxation rate versus concentration relationship, Gd-DTPA enhancement in MR images may be a good marker of relative organ perfusion. (nih.gov)
  • To define the time course and mechanism of enhancement of epidural fibrosis after gadolinium-DTPA (Gd-DTPA) injection, we undertook a three-part study in humans and dogs with epidural scar after spine surgery. (ajnr.org)
  • However, the Gd-DTPA enhancement characteristics of acutely injured peripheral nerves have not been fully examined. (elsevier.com)
  • This study was performed to determine whether acutely crushed rat sciatic nerves demonstrate Gd-DTPA enhancement and, if so, to evaluate whether enhancement is affected by crush severity. (elsevier.com)
  • 04). CONCLUSIONS: Gd-DTPA enhancement of peripheral nerves may only occur above a certain crush-severity threshold. (elsevier.com)
  • This phenomenon may explain the intermittent observation of Gd-DTPA enhancement of peripheral nerves after traumatic injury. (elsevier.com)
  • Fingerprint Dive into the research topics of 'Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T'. Together they form a unique fingerprint. (elsevier.com)
  • Gadolinium DTPA enhancement characteristics of the rat sciatic nerve after crush injury at 4.7T. / Hill, B. J. (elsevier.com)
  • Enhancement after Gd-DTPA enabled distinction between necrotic and viable tumour and blood clot. (openrepository.com)
  • Mucosal hyperintensity, thickening and abnormal signal intensity of the muscular layers of the bladder wall, with enhancement after Gd-DTPA were demonstrated. (openrepository.com)
  • Enhancement after Gd-DTPA does not therefore reliably distinguish between recurrent tumour and radiotherapy change. (openrepository.com)
  • Jeong YY, Mitchell DG, Holland GA. Liver lesion conspicuity: T2-weighted breath-hold fast spin-echo MR imaging before and after gadolinium enhancement-initial experience. (springer.com)
  • MRI was performed 2 hours after probe injection, to avoid nonspecific signal from the late gadolinium enhancement effect. (biomedsearch.com)
  • Nonspecific IgG-conjugated gadolinium nanoprobe-injected animals in all groups did not show vessel wall enhancement. (ahajournals.org)
  • Areas of USPIO uptake are clearly different from gadolinium enhancement. (omicsonline.org)
  • Gadolinium-enhanced magnetic resonance angiography (MRA) scans of the hands disclosed marked enhancement of all DIP joints ( Figure 1B ) without bony erosion or bone marrow edema. (jrheum.org)
  • B. Gadolinium-enhanced magnetic resonance angiography shows marked enhancement of all DIP joints. (jrheum.org)
  • Magnetic resonance imaging (MRI) rates of early synovial enhancement after injection of gadolinium have been shown to correlate closely with the histological grade of synovitis 9 , 10 . (jrheum.org)
  • Magnetic resonance (MR) imaging was performed on 40 patients with intracranial tumors, before and after intravenous administration of gadolinium-DTPA (Gd-DTPA). (nih.gov)
  • Magnetic Resonance Imaging (MRI) with intravenous Gadolinium-DTPA (Gd-DTPA, Magnevist, Schering-AG) was performed in 44 patients, 32 with primary bladder carcinoma and 12 with suspected recurrence after treatment. (openrepository.com)
  • Contrast-en- conventional method to measure the LSR using two-di- hanced 3D fat-suppressed T1-weighted images were mensional (2D) regions of interest might be affected by obtained 20 min after intravenous administration of Gd- sampling errors or inter-evaluator variability [9]. (deepdyve.com)
  • For several of those CMR protocols, such as myocardial perfusion imaging, MR angiography, or noninvasive tissue characterization, gadolinium-based contrast agents are necessary. (onlinejacc.org)
  • The effect of intra‐articular gadolinium‐DTPA on synovial membrane and cartilage. (currentprotocols.com)
  • We studied whether a triple dose of gadolinium-DTPA alone or in combination with delayed scanning increases the sensitivity of brain MRI for detecting enhancing lesions in patients with MS. We obtained T1-weighted brain MRI scans in two sessions for 22 patients with clinically definite MS. In the first session, we obtained one scan 5 to 7 minutes after the injection of 0.1 mmol/kg gadolinium-DTPA (standard dose). (mdc-berlin.de)
  • In the second session, 6 to 24 hours later, we obtained one scan before the two scans 5 to 7 minutes (for all patients) and one hour (for 11 patients) after the injection of 0.3 mmol/kg gadolinium-DTPA (triple dose). (mdc-berlin.de)
  • There was an increase in the number of large enhancing lesions (p = 0.03) in the scans obtained 1 hour after the injection of the triple dose of gadolinium-DTPA. (mdc-berlin.de)
  • Gadolinium-DTPA-enhanced magnetic resonance scanning in cerebellopontine angle tumors. (rochester.edu)
  • 1. L'àcid gadopentètic permet, mitjançant la injecció endovenosa, obtenir informació fiable en l'estudi de la mama i distingir de manera clara entre tumors benignes i tumors malignes. (termcat.cat)
  • Gadolinium neutron capture therapy (GdNCT) of melanoma cells and solid tumors with the magnetic resonance imaging contrast agent Gadobutrol. (semanticscholar.org)
  • Zurück zum Zitat Vogl TJ, Kummel S, Hammerstingl R et al (1996) Liver tumors: comparison of MR imaging with Gd-EOB-DTPA and Gd-DTPA. (springermedizin.de)
  • 8. *Dickman CA, Rekate HL, Bird CR, Drayer BP, Medina M: Unenhanced and Gadolinium-DTPA-Enhanced MR Imaging in Postoperative Evaluation in Pediatric Brain Tumors. (spineuniverse.com)
  • MRI using gadolinium contrast media plays an important role in the differential diagnosis of other brain tumors. (scirp.org)
  • Compared to other gadolinium-based MRI contrast agents, Gadopentetate dimeglumine (Gd-DTPA2-) chelates allow delayed Gadolinium-enhanced Magnetic Resonance of Cartilage (dGEMRIC). (wikipedia.org)
  • BACKGROUND AND PURPOSE After the advent of extracellular contrast media, hepatobiliary-specific gadolinium chelates were developed to improve the diagnostic value of MR imaging of the liver. (semanticscholar.org)
  • We will also discuss specific issues related to MRI, such as allergic reactions to gadolinium chelates, side-effects of gadolinium, nephrogenic systemic fibrosis (NSF), and its use in patients with renal failure and on dialysis. (appliedradiology.com)
  • MRI has many advantages over CT, such as lack of ionizing radiation, superior contrast resolution, multiplanar capabilities, and an excellent safety profile of gadolinium chelates. (appliedradiology.com)
  • After administration of Gd-DTPA (0.1 mmol/kg), increased signal intensity from the tumor was observed in all patients. (nih.gov)
  • Bashir A, Gray ML, Boutin RD, Burstein D. Glycosaminoglycan in articular cartilage: in vivo assessment with delayed Gd(DTPA)(2-)-enhanced MR imaging. (wikipedia.org)
  • In vivo transport of Gd-DTPA2- into human meniscus and cartilage assessed with delayed gadolinium-enhanced MRI of cartilage (dGEMRIC). (nih.gov)
  • Delayed gadolinium-enhanced MRI of cartilage (dGEMRIC) has been used to identify pre-radiographic changes in the cartilage in OA, but has been used less commonly to examine the meniscus, and then using only a double dose of the contrast agent. (nih.gov)
  • Delayed gadolinium enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a novel technique that allows early diagnosis of osteoarthritis (OA). (mit.edu)
  • In this work, a series of seven gadolinium complexes are described which provide excellent derivatives for anomalous diffraction experiments in bio-logical systems. (iucr.org)
  • Using one of these gadolinium complexes, Gd-HPDO3A, the structure of a bacterial chimeric ornithine carbamoyl transferase, OTCase3630, a dodecameric protein of 450 kDa, was determined. (iucr.org)
  • To study more specifically the activity of hepatocyte transporters in vivo , radiotracers for positron emission tomography (PET) and single-photon emission computed tomography (SPECT) imaging and gadolinium complexes for magnetic resonance imaging (MRI) can be injected before the image acquisition [ 1 - 4 ]. (hindawi.com)
  • Artefacts due to variable and inhomogeneous urine signal intensity, however, often degraded post-Gd-DTPA images of the bladder. (openrepository.com)
  • The signal intensity/time curves showed that brain signal intensity increased more in the diabetic group than controls during the first 15 minutes after Gd-DTPA, particularly in the basal ganglia (p=0.018). (bmj.com)
  • Different signal intensity at Gd-EOB-DTPA compared with Gd-DTPA-enhanced MRI in hepatocellular carcinoma transgenic mouse model in delayed phase hepatobiliary imaging. (semanticscholar.org)
  • III: Gadolinium-based hepatobiliary contrast agents (Gd-EOB-DTPA and Gd-BOPTA/Dimeg). (semanticscholar.org)
  • Zurück zum Zitat Hamm B, Staks T, Muhler A et al (1995) Phase I clinical evaluation of Gd-EOB-DTPA as a hepatobiliary MR contrast agent: safety, pharmacokinetics, and MR imaging. (springermedizin.de)
  • Early phase detection of bile leak after hepatobiliary surgery: value of Gd-EOB-DTPA-enhanced MR cholangiography. (ebscohost.com)
  • The nanoparticle contains internal gadolinium ions for T 1 imaging contrast, located between an inner core and outer Au layer, in a multilayered geometry. (pnas.org)
  • Gadolinium based agents may cause a toxic reaction known as nephrogenic systemic fibrosis (NSF) in patients with severe kidney problems. (wikipedia.org)
  • Grobner T (2006) Gadolinium-a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis? (springermedizin.de)
  • however, nephrogenic systemic fibrosis is a serious side effect of gadolinium exposure. (scirp.org)
  • However, it has been reported that nephrogenic systemic fibrosis (NSF) is a serious side effect of gadolinium contrast media. (scirp.org)
  • Synthesis and characterization of gadolinium nanostructured materials with potential applications in magnetic resonance imaging, neutron-capture therapy and targeted drug delivery. (ebscohost.com)
  • Zurück zum Zitat Reimer P, Rummeny EJ, Shamsi K et al (1996) Phase II clinical evaluation of Gd-EOB-DTPA: dose, safety aspects, and pulse sequence. (springermedizin.de)
  • Gadolinium-DTPA complex (Gd-DTPA) is a potential clinical magnetic resonance (MR) contrast agent that enhances images primarily by decreasing spin-lattice relaxation time (T1) in tissues in which it localizes. (nih.gov)
  • Gadolinium-DTPA as a contrast agent in MRI: initial clinical experience in 20 patients. (springer.com)
  • Dynamic MR imaging of the liver with gd-DTPA: initial clinical results. (springer.com)
  • Biochemical properties of gadolinium-based contrast agents currently approved for clinical use. (frontiersin.org)
  • The role of premedication to mitigate reaction to gadolinium has not been well studied in clinical trials. (appliedradiology.com)
  • Hamm B, Wolf KJ, Felix R (1987) Conventional and rapid MR imaging of the liver with gadolinium DTPA. (springer.com)
  • Gd-DTPA often increased diagnostic confidence in the identification and staging of tumours confined to the bladder wall and was necessary to assess depth of bladder wall invasion when T2-weighted images were suboptimal. (openrepository.com)
  • Such gadolinium conjugates may therefore be of value in the development of novel diagnostic and therapeutic agents. (aspetjournals.org)
  • Residual gadolinium is deposited not only in brain, but also in extracranial tissues such as liver, skin, and bone. (frontiersin.org)
  • Kanal E, Tweedle MF (2015) Residual or retained gadolinium: practical implications for radiologists and our patients. (springermedizin.de)
  • Four-dimensional fully convolutional residual network-based liver segmentation in Gd-EOB-DTPA-enhanced MRI. (bioportfolio.com)
  • We detected 83 enhancing lesions in 14 patients when the standard dose of gadolinium-DTPA was used. (mdc-berlin.de)
  • p = 0.001) and the numbers of patients with such lesions to 18 (increase 28%) when we used the triple dose of gadolinium-DTPA. (mdc-berlin.de)
  • These data indicate that in patients with MS, a triple dose of gadolinium-DTPA can reveal many more enhancing lesions, which also appear larger. (mdc-berlin.de)
  • T 1 weighted spin echo pre -(T 1 ), post-gadolinium (T 1 /Gd-DTPA) and short tau inversion recovery (STIR) MRI sequences were used to assess chronic and active spinal lesions using the scoring system ASspiMRI. (bmj.com)
  • Improvement of inflammatory spinal lesions in a patient with ankylosing spondylitis in the T1/Gd-DTPA MRI sequence before (A) and after (B) treatment with etanercept. (bmj.com)
  • B) Pre-Gd T2 MRI on a MS patient demonstrates multiple lesions, and while there is a DTPA-Gd and USPIO enhancing lesions (arrow), there also is an USPIO-uptake-only lesion (arrowhead). (omicsonline.org)
  • Whereas most of the meningiomas, neuromas, and adenomas could be delineated prior to administration of contrast material if appropriate pulse sequences were applied, glioblastomas and intracranial metastases required Gd-DTPA administration for diagnostically sufficient tumor display. (nih.gov)
  • Gd-DTPA may therefore be useful in selected patients with tumours of Stage T3a or less in whom information about depth of bladder wall invasion is inadequately shown on pre-contrast sequences. (openrepository.com)
  • T 1 /Gd-DTPA sequences gave similar results. (bmj.com)
  • This study was designed to determine the immediate tissue distribution of intravenously administered Gd-DTPA in selected organs of interest as a function of administered dose and tissue Gd-DTPA concentration. (nih.gov)
  • Pigs underwent multiple injections with dilute gadolinium-DTPA. (ahajournals.org)
  • Objectives The purpose of this study was to assess the frequency, manifestation, and severity of acute adverse reactions associated with administration of several gadolinium-based contrast agents to patients who underwent cardiac magnetic resonance (CMR) imaging in the EuroCMR (European Cardiovascular Magnetic Resonance) Registry multinational and multicenter setting. (onlinejacc.org)
  • Postmortem human or animal studies have validated gadolinium deposition in these T1-hyperintensity areas, raising new concerns on the safety of gadolinium-based contrast agents (GBCAs). (frontiersin.org)
  • This review summarizes the current evidence on gadolinium deposition in the human and animal bodies, evaluates the effects of different types of GBCAs on the gadolinium deposition, introduces the possible entrance or clearance mechanism of the gadolinium and potential side effects that may be related to the gadolinium deposition on human or animals, and puts forward some suggestions for further research. (frontiersin.org)
  • Clinically available GBCAs are all bonded by a ligand when they are used as an MRI contrast agent because free gadolinium is highly toxic ( Rogosnitzky and Branch, 2016 ). (frontiersin.org)
  • In this review, we summarize the current evidence on gadolinium deposition in the human and animal bodies, evaluate the effect of different types of GBCAs on the gadolinium deposition in brain, introduce the possible entrance or clearance mechanism of the gadolinium and potential side effects of gadolinium deposition in brain, and put forward some suggestions for further research. (frontiersin.org)
  • Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. (nih.gov)
  • MRI contrast agent for targeting glioma: interleukin-13 labeled liposome encapsulating gadolinium-DTPA. (psu.edu)
  • Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. (wikipedia.org)
  • After gadolinium imaging, a T1 image of the spin echo method was used. (scirp.org)
  • Methods and Results- Anti-Mrp-14 and nonspecific IgG-conjugated gadolinium nanoprobes (aMrp-) were synthesized and characterized. (ahajournals.org)
  • 2 However, in all these studies, a standard dose of gadolinium (Gd) was used and, in addition, complete suppression of MRI-detected inflammation was never achieved. (bmj.com)
  • In the past 4 years, many publications described a concentration-dependent deposition of gadolinium in the brain both in adults and children, seen as high signal intensities in the globus pallidus and dentate nucleus on unenhanced T1-weighted images. (frontiersin.org)
  • focused on the potential risks of gadolinium retention in the human brain. (frontiersin.org)
  • Gadolinium is highly toxic and the accumulation of gadolinium in the brain has become a concern. (wikipedia.org)
  • Subsequently, magnetic resonance imaging (MRI GE, 3 Tesla) of the brain, with and without gadolinium (DTPA), was ordered. (thefreelibrary.com)
  • Moreover, it turns out that gadolinium deposits in the brain. (scirp.org)
  • Considering the distribution of gadolinium contrast media in the brain, I started the image pick-up 5 minutes after pouring the contrast media. (scirp.org)
  • Gadolinium is retained for months or years in brain, bone, and other organs. (nih.gov)
  • Subjects with more white matter hyperintensities had greater signal increase after Gd-DTPA, whether diabetic or not (p=0.001). (bmj.com)
  • Zurück zum Zitat Zech CJ, Herrmann KA, Reiser MF et al (2007) MR imaging in patients with suspected liver metastases: value of liver-specific contrast agent Gd-EOB-DTPA. (springermedizin.de)
  • Magnetic resonance imaging with Gadolinium-DTPA for assessment of bladder carcinoma and its response to treatment. (openrepository.com)
  • Assessment of vascularity of the femoral head using gadolinium (Gd-DTPA)-enhanced magnetic resonance imaging: a cadaver study. (semanticscholar.org)
  • Administration of intraarticular gadolinium enhances the MRI appearance of the labrum to improve detection of labral abnormalities. (duke.edu)
  • Follow-up of intracranial aneurysms treated with detachable coils: comparison of gadolinium-enhanced 3D time-of-flight MR angiography and digital s. (nih.gov)
  • would require the accumulation of a Gd-DTPA conjugate in the cell nucleus. (aspetjournals.org)