Gadolinium dtpa. Medical search

Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

An iron chelating agent with properties like EDETIC ACID. DTPA has also been used as a chelator for other metals, such as plutonium.

Substances used to allow enhanced visualization of tissues.

A class of compounds of the type R-M, where a C atom is joined directly to any other element except H, C, N, O, F, Cl, Br, I, or At. (Grant & Hackh's Chemical Dictionary, 5th ed)

A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.

The first artificially produced element and a radioactive fission product of URANIUM. Technetium has the atomic symbol Tc, atomic number 43, and atomic weight 98.91. All technetium isotopes are radioactive. Technetium 99m (m=metastable) which is the decay product of Molybdenum 99, has a half-life of about 6 hours and is used diagnostically as a radioactive imaging agent. Technetium 99 which is a decay product of technetium 99m, has a half-life of 210,000 years.

Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.

A metallic element, atomic number 49, atomic weight 114.82, symbol In. It is named from its blue line in the spectrum. (From Dorland, 28th ed)

A type of imaging technique used primarily in the field of cardiology. By coordinating the fast gradient-echo MRI sequence with retrospective ECG-gating, numerous short time frames evenly spaced in the cardiac cycle are produced. These images are laced together in a cinematic display so that wall motion of the ventricles, valve motion, and blood flow patterns in the heart and great vessels can be visualized.

Americium. A completely man-made radioactive actinide with atomic symbol Am, atomic number 95, and atomic weight 243. Its valence can range from +3 to +6. Because of its nonmagnetic ground state, it is an excellent superconductor. It is also used in bone mineral analysis and as a radiation source for radiotherapy.

Unstable isotopes of indium that decay or disintegrate emitting radiation. In atoms with atomic weights 106-112, 113m, 114, and 116-124 are radioactive indium isotopes.

1-Deoxy-1-(methylamino)-D-glucitol. A derivative of sorbitol in which the hydroxyl group in position 1 is replaced by a methylamino group. Often used in conjunction with iodinated organic compounds as contrast medium.

Ring compounds having atoms other than carbon in their nuclei. (Grant & Hackh's Chemical Dictionary, 5th ed)

An iodine-containing compound used in pyelography as a radiopaque medium. If labeled with radioiodine, it can be used for studies of renal function.

Porphyrins which are combined with a metal ion. The metal is bound equally to all four nitrogen atoms of the pyrrole rings. They possess characteristic absorption spectra which can be utilized for identification or quantitative estimation of porphyrins and porphyrin-bound compounds.

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS.

Graphic tracing over a time period of radioactivity measured externally over the kidneys following intravenous injection of a radionuclide which is taken up and excreted by the kidneys.

Abnormal fluid retention by the body due to impaired cardiac function or heart failure. It is usually characterized by increase in venous and capillary pressure, and swollen legs when standing. It is different from the generalized edema caused by renal dysfunction (NEPHROTIC SYNDROME).

Ytterbium. An element of the rare earth family of metals. It has the atomic symbol Yb, atomic number 70, and atomic weight 173. Ytterbium has been used in lasers and as a portable x-ray source.

Improvement of the quality of a picture by various techniques, including computer processing, digital filtering, echocardiographic techniques, light and ultrastructural MICROSCOPY, fluorescence spectrometry and microscopy, scintigraphy, and in vitro image processing at the molecular level.

Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.

Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.

A class of organic compounds containing a ring structure made up of more than one kind of atom, usually carbon plus another atom. The ring structure can be aromatic or nonaromatic.

Colloids with a gaseous dispersing phase and either liquid (fog) or solid (smoke) dispersed phase; used in fumigation or in inhalation therapy; may contain propellant agents.

Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)

Techniques for labeling a substance with a stable or radioactive isotope. It is not used for articles involving labeled substances unless the methods of labeling are substantively discussed. Tracers that may be labeled include chemical substances, cells, or microorganisms.

Unstable isotopes of tin that decay or disintegrate emitting radiation. Sn atoms with atomic weights 108-111, 113, 120-121, 123 and 125-128 are tin radioisotopes.

The fluid separating the membranous labyrinth from the osseous labyrinth of the ear. It is entirely separate from the ENDOLYMPH which is contained in the membranous labyrinth. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1396, 642)

Specialized phagocytic cells of the MONONUCLEAR PHAGOCYTE SYSTEM found on the luminal surface of the hepatic sinusoids. They filter bacteria and small foreign proteins out of the blood, and dispose of worn out red blood cells.

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

Elements of limited time intervals, contributing to particular results or situations.

The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

The study of the chemical and physical phenomena of radioactive substances.

An involuntary or voluntary pause in breathing, sometimes accompanied by loss of consciousness.

Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.

One of three principal openings in the SUBARACHNOID SPACE. They are also known as cerebellomedullary cistern, and collectively as cisterns.

A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).

A technique for analysis of the chemical composition of molecules. A substance is bombarded with monochromatic ELECTRONS. Some of the electrons passing through the specimen will lose energy when they ionize inner shell electrons of the atoms in the specimen. The energy loss is element dependent. Analysis of the energy loss spectrum reveals the elemental composition of a specimen. ENERGY-FILTERED TRANSMISSION ELECTRON MICROSCOPY is a type of electron energy loss spectroscopy carried out in electron microscopes specially outfitted to analyze the spectrum of electron energy loss.

The spontaneous transformation of a nuclide into one or more different nuclides, accompanied by either the emission of particles from the nucleus, nuclear capture or ejection of orbital electrons, or fission. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)

Hypertension due to RENAL ARTERY OBSTRUCTION or compression.

Radiotherapy where cytotoxic radionuclides are linked to antibodies in order to deliver toxins directly to tumor targets. Therapy with targeted radiation rather than antibody-targeted toxins (IMMUNOTOXINS) has the advantage that adjacent tumor cells, which lack the appropriate antigenic determinants, can be destroyed by radiation cross-fire. Radioimmunotherapy is sometimes called targeted radiotherapy, but this latter term can also refer to radionuclides linked to non-immune molecules (see RADIOTHERAPY).

A form of CARDIAC MUSCLE disease, characterized by left and/or right ventricular hypertrophy (HYPERTROPHY, LEFT VENTRICULAR; HYPERTROPHY, RIGHT VENTRICULAR), frequent asymmetrical involvement of the HEART SEPTUM, and normal or reduced left ventricular volume. Risk factors include HYPERTENSION; AORTIC STENOSIS; and gene MUTATION; (FAMILIAL HYPERTROPHIC CARDIOMYOPATHY).

Transmission of energy or mass by a medium involving movement of the medium itself. The circulatory movement that occurs in a fluid at a nonuniform temperature owing to the variation of its density and the action of gravity. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed; Webster, 10th ed)

The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD.

Iron (II,III) oxide (Fe3O4). It is a black ore of IRON that forms opaque crystals and exerts strong magnetism.

Methods developed to aid in the interpretation of ultrasound, radiographic images, etc., for diagnosis of disease.

The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.

Volume of biological fluid completely cleared of drug metabolites as measured in unit time. Elimination occurs as a result of metabolic processes in the kidney, liver, saliva, sweat, intestine, heart, brain, or other site.

Injections made into a vein for therapeutic or experimental purposes.

Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.

Reduction of CEREBROSPINAL FLUID pressure characterized clinically by HEADACHE which is maximal in an upright posture and occasionally by an abducens nerve palsy (see ABDUCENS NERVE DISEASES), neck stiffness, hearing loss (see DEAFNESS); NAUSEA; and other symptoms. This condition may be spontaneous or secondary to SPINAL PUNCTURE; NEUROSURGICAL PROCEDURES; DEHYDRATION; UREMIA; trauma (see also CRANIOCEREBRAL TRAUMA); and other processes. Chronic hypotension may be associated with subdural hematomas (see HEMATOMA, SUBDURAL) or hygromas. (From Semin Neurol 1996 Mar;16(1):5-10; Adams et al., Principles of Neurology, 6th ed, pp637-8)

The creation and display of functional images showing where the blood is flowing into the MYOCARDIUM by following over time the distribution of tracers injected into the blood stream.

An effective non-ionic, water-soluble contrast agent which is used in myelography, arthrography, nephroangiography, arteriography, and other radiographic procedures. Its low systemic toxicity is the combined result of low chemotoxicity and low osmolality.

Chemical agents that increase the permeability of CELL MEMBRANES to CALCIUM ions.

Narrowing or occlusion of the RENAL ARTERY or arteries. It is due usually to ATHEROSCLEROSIS; FIBROMUSCULAR DYSPLASIA; THROMBOSIS; EMBOLISM, or external pressure. The reduced renal perfusion can lead to renovascular hypertension (HYPERTENSION, RENOVASCULAR).

A chelating agent that sequesters a variety of polyvalent cations such as CALCIUM. It is used in pharmaceutical manufacturing and as a food additive.

Organic compounds that contain technetium as an integral part of the molecule. These compounds are often used as radionuclide imaging agents.

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.

Elements of the lanthanoid series including atomic number 57 (LANTHANUM) through atomic number 71 (LUTETIUM).

The amount of BLOOD pumped out of the HEART per beat, not to be confused with cardiac output (volume/time). It is calculated as the difference between the end-diastolic volume and the end-systolic volume.

Cells specialized to transduce mechanical stimuli and relay that information centrally in the nervous system. Mechanoreceptor cells include the INNER EAR hair cells, which mediate hearing and balance, and the various somatosensory receptors, often with non-neural accessory structures.

Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes.

Cyclic N-oxide radical functioning as a spin label and radiation-sensitizing agent.

The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)

A mercaptodicarboxylic acid used as an antidote to heavy metal poisoning because it forms strong chelates with them.

Devices or objects in various imaging techniques used to visualize or enhance visualization by simulating conditions encountered in the procedure. Phantoms are used very often in procedures employing or measuring x-irradiation or radioactive material to evaluate performance. Phantoms often have properties similar to human tissue. Water demonstrates absorbing properties similar to normal tissue, hence water-filled phantoms are used to map radiation levels. Phantoms are used also as teaching aids to simulate real conditions with x-ray or ultrasonic machines. (From Iturralde, Dictionary and Handbook of Nuclear Medicine and Clinical Imaging, 1990)

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI. (1/1258)

The aim of this study was two-fold: to compare 67Ga scintigraphy with MRI (a) for the staging of malignant lymphoma of the bone and (b) with regard to accuracy in detecting residual disease after first-line chemotherapy for restaging. METHODS: Twenty-one patients with 36 malignant osseous lesions were examined, including 7 patients with primary or multifocal osseous lymphoma and 14 patients with malignant lymphoma and simultaneous or secondary involvement of the bone. After first-line therapy, MRI and 67Ga scintigraphy were performed on 13 patients. The remission status based on all clinical and radiological findings during the follow-up was used as the gold standard. RESULTS: The osseous lesions were located on the axial skeleton in 64% of patients and on the appendicular skeleton in 36%. 67Ga scintigraphy detected 77% of the osseous lesions examined by MRI. For restaging after first-line therapy, MRI had a sensitivity of 90% and a specificity of 80% when dynamic MRI information was included. There were several false-positive results as a result of the pathologic increase in signal intensity ratios of reactive hematopoietic regions after chemotherapy. For 67Ga scintigraphy, a sensitivity of 70% and a specificity of 93% were calculated. CONCLUSION: These data show that monitoring malignant lymphoma of the bone still presents diagnostic problems. Given the high sensitivity of MRI and the high specificity of 67Ga scintigraphy but the limited specificity of MRI and sensitivity of 67Ga scintigraphy, both methods are valuable but should be used as complementary diagnostic tools. (+info)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1258)

Annular tears are manifest on MRI as the high-intensity zone (HIZ) or as annular enhancement. Patients with annular tears may experience low back pain with radiation into the lower limb in the absence of nerve root compression. Inflammation of nerve roots from leak of degenerative nuclear material through full-thickness annular tears is a proposed mechanism for such leg pain. The aim of this study is to illustrate the appearance of extradural enhancement adjacent to annular tears in patients being investigated for low back pain with radiation into the lower limb(s). Sagittal T1- and T2-weighted spin echo and axial T1-weighted spin echo sequences were obtained in eight patients being investigated for low back and leg pain. In all patients, the T1-weighted sequences were repeated following intravenous gadopentetate dimeglumine (Gd-DTPA). Annular tears were identified at 12 sites in eight patients. Extradural inflammation appeared as a region of intermediate signal intensity replacing the fat between the posterior disc margin and the theca, which enhanced following Gd-DTPA. The inflammatory change was always associated with an annular tear, and in four cases directly involved the nerve root. Enhancement of the nerve root was seen in two cases. The findings may be relevant in the diagnosis of chemical radiculopathy secondary to inflammation at the site of an annular leak from a degenerating disc. (+info)

A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. (3/1258)

OBJECTIVES: The purpose of this study was to evaluate a myocardial perfusion reserve index (MPRI) derived from a quantitative magnetic resonance imaging (MRI) technique in normal human volunteers and patients with coronary artery disease and to relate MPRI to coronary artery stenosis severity measured with quantitative arteriography. BACKGROUND: Magnetic resonance imaging could be a useful noninvasive tool in the investigation of ischemic heart disease. However, there have been few studies in humans to quantify myocardial perfusion and myocardial perfusion reserve using MRI and none in patients with coronary disease. METHODS: Twenty patients with angiographically proven coronary artery disease and five normal volunteers underwent both resting and stress (adenosine 140 microg/kg(-1)/min(-1)) first-pass contrast-enhanced MRI examinations (using 0.05 mmol/kg 1 of gadopentetate dimeglumine. Using a tracer kinetic model, the unidirectional transfer constant (K(i)), a perfusion marker for the myocardial uptake of contrast, was computed in each coronary arterial territory. The ratio of K(i) for the rest and stress scans was used to calculate the MPRI. Percent reduction in luminal diameter of coronary lesions was measured using an automated edge-detection algorithm. RESULTS: Myocardial perfusion reserve index was significantly reduced in patients compared with normal subjects (2.02+/-0.7 vs. 4.21+/-1.16, p < 0.02). For regions supplied by individual vessels, there was a significant negative correlation of MPRI with percent diameter stenosis (r = -0.81, p < 0.01). Importantly, regions supplied by vessels with <40% diameter stenosis (non-flow limiting) had a significantly higher MPRI than regions supplied by stenoses of "intermediate" severity, that is, >40% to 59% diameter stenosis (2.80+/-0.77 and 1.93+/-0.38, respectively, p < 0.02). However, even regions supplied by vessels with <40% diameter stenosis had a significantly lower MPRI than volunteers (p < 0.01). CONCLUSIONS: A myocardial perfusion reserve index derived from first-pass MRI studies can distinguish between normal subjects and patients with coronary artery disease. Furthermore, it provides useful functional information on coronary lesions, particularly where the physiologic significance cannot be predicted accurately from the angiogram. (+info)

Statistical power of MRI monitored trials in multiple sclerosis: new data and comparison with previous results. (4/1258)

OBJECTIVES: To evaluate the durations of the follow up and the reference population sizes needed to achieve optimal and stable statistical powers for two period cross over and parallel group design clinical trials in multiple sclerosis, when using the numbers of new enhancing lesions and the numbers of active scans as end point variables. METHODS: The statistical power was calculated by means of computer simulations performed using MRI data obtained from 65 untreated relapsing-remitting or secondary progressive patients who were scanned monthly for 9 months. The statistical power was calculated for follow up durations of 2, 3, 6, and 9 months and for sample sizes of 40-100 patients for parallel group and of 20-80 patients for two period cross over design studies. The stability of the estimated powers was evaluated by applying the same procedure on random subsets of the original data. RESULTS: When using the number of new enhancing lesions as the end point, the statistical power increased for all the simulated treatment effects with the duration of the follow up until 3 months for the parallel group design and until 6 months for the two period cross over design. Using the number of active scans as the end point, the statistical power steadily increased until 6 months for the parallel group design and until 9 months for the two period cross over design. The power estimates in the present sample and the comparisons of these results with those obtained by previous studies with smaller patient cohorts suggest that statistical power is significantly overestimated when the size of the reference data set decreases for parallel group design studies or the duration of the follow up decreases for two period cross over studies. CONCLUSIONS: These results should be used to determine the duration of the follow up and the sample size needed when planning MRI monitored clinical trials in multiple sclerosis. (+info)

Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits. (5/1258)

BACKGROUND/AIMS: To investigate a poly(2-hydroxyethyl methacrylate) (PHEMA) orbital implant with a spongy anterior hemisphere and a smooth gel posterior hemisphere, by histology correlated with magnetic resonance images. METHODS: Following enucleation, eight rabbits received PHEMA implants to which the muscles were directly sutured, and underwent gadolinium enhanced magnetic resonance imaging (MRI) from 3 to 52 weeks. After the rabbits were killed, the implants were removed, cut in a plane corresponding to the scan, and processed for light and electron microscopy. RESULTS: All eight rabbits retained their implant to the end of the study period without complications. The scans demonstrated muscle attachment to the anterior half of the implant, and enhancement was seen on injection of gadolinium chelate. Histology confirmed muscle attachment, and cellular and vascular ingrowth. Over time, a transformation from reactive inflammatory to relatively non-vascular scar tissue was seen within the implant. Calcium deposits in one implant were detected by imaging and histology. CONCLUSION: The implants are readily visualised on MRI. Muscle attachment and fibrovascular ingrowth into the anterior hemisphere are seen, while encapsulation of the posterior hemisphere is minimal. Histological findings confirm the progress of the healing response, with initial inflammation and marked vascularisation, developing later into quiescent scar tissue predominantly of fibroblasts. (+info)

Cell water balance of white button mushrooms (Agaricus bisporus) during its post-harvest lifetime studied by quantitative magnetic resonance imaging. (6/1258)

A combination of quantitative water density and T2 MRI and changes therein observed after infiltration with 'invisible' Gd-DTPA solution was used to study cell water balances, cell water potentials and cell integrity. This method was applied to reveal the evolution and mechanism of redistribution of water in harvested mushrooms. Even when mushrooms did not lose water during the storage period, a redistribution of water was observed from stipe to cap and gills. When the storage condition resulted in a net loss of water, the stipe lost more water than the cap. The water density in the gill increased, probably due to development of spores. Deterioration effects (i.e. leakage of cells, decrease in osmotic water potential) were found in the outer stipe. They were not found in the cap, even at prolonged storage at 293 K and R.H.=70%. The changes in osmotic potential were partly accounted for by changes in the mannitol concentration. Changes in membrane permeability were also indicated. Cells in the cap had a constant low membrane (water) permeability. They developed a decreasing osmotic potential (more negative), whereas the osmotic potential in the outer stipe increased, together with the permeability of cells. (+info)

Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. (7/1258)

Lipoblastomatosis is a locally infiltrative tumor of embryonic fat. We describe the MR appearance of cervical lipoblastomatosis with epidural extension. The initial MR study showed features of a soft-tissue mass; a subsequent MR examination, performed after chemotherapy, depicted the lesion as a typical lipoma of high signal intensity on T1-weighted images and of intermediate signal on T2-weighted sequences. (+info)

Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (8/1258)

We describe imaging findings in a 2-year-old girl with neurocutaneous melanosis and malignant cerebral melanoma. Because the cerebral melanoma in this child was of the amelanotic type, high-signal intensity on unenhanced T1-weighted images was not present. The cutaneous lesions played a crucial role in establishing a correct (presumed) histopathologic diagnosis on the basis of the imaging findings. To our knowledge this is the first report describing an intracranial amelanotic malignant melanoma in association with neurocutaneous melanosis. (+info)

Weinmann HJ, Brasch RC, Press WR, Wesbey GE (March 1984). "Characteristics of gadolinium-DTPA complex: a potential NMR contrast ... Most commonly, a paramagnetic contrast agent (usually a gadolinium compound) is given. Gadolinium-enhanced tissues and fluids ... MRI contrast agents, such as those containing Gadolinium(III) work by altering (shortening) the relaxation parameters, ... There have been concerns raised recently regarding the toxicity of gadolinium-based contrast agents and their impact on persons ...

https://en.wikipedia.org/wiki/Physics_of_magnetic_resonance_imaging

Gd-DTPA is classed as an acyclic, ionic gadolinium contrast medium. Its paramagnetic property reduces the T1 relaxation time ( ... It is usually administered as a salt of a complex of gadolinium with DTPA (diethylenetriaminepentacetate) with the chemical ... Gadolinium is highly toxic and the accumulation of gadolinium in the brain has become a concern. The EU banned linear chelates ... Compared to other gadolinium-based MRI contrast agents, Gadopentetate dimeglumine (Gd-DTPA2-) chelates allow delayed Gadolinium ...

https://en.wikipedia.org/wiki/Gadopentetic_acid

"Initial clinical evaluation of gadolinium DTPA for contrast-enhanced magnetic resonance imaging". Magnetic Resonance Imaging. 3 ... Runge was one of the early researchers to investigate the use of gadolinium-based contrast agents for magnetic resonance ... This identifies a pathway by which linear gadolinium chelates may produce ill effects in otherwise normal patients long after ... In 2019, under his guidance, the first study demonstrating the toxicity of gadolinium chelates to brain tissue was published. ...

https://en.wikipedia.org/wiki/Val_Murray_Runge

The structure of [Gd(DTPA)(H2O)]2− is a distorted tricapped trigonal prism. The following is the reaction for the formation of ... Gadolinium(III) chloride, also known as gadolinium trichloride, is GdCl3. It is a colorless, hygroscopic, water-soluble solid. ... "Gadolinium". Magnetic Resonance TIP-MRI Database. Retrieved February 22, 2006. "Gadolinium". Webelements. Retrieved February 22 ... C from gadolinium oxide: 10 NH4Cl + Gd2O3 → 2 (NH4)2[GdCl5] + 6 NH3 + 3 H2O from hydrated gadolinium chloride: 4 NH4Cl + 2 ...

https://en.wikipedia.org/wiki/Gadolinium(III)_chloride

DTPA is also used as a complexing agent for gadolinium in MRI contrast enhancement. The requirement in this case is that the ... Ligands such as DTPA, which have eight donor atoms are used to form complexes with large metal ions such as lanthanide or ... In addition the ligand occupies only 8 of the 9 coordination sites on the gadolinium ion. The ninth site is occupied by a water ... Excess copper in Wilson's disease can be removed by penicillamine or Triethylene tetramine (TETA). DTPA has been approved by ...

https://en.wikipedia.org/wiki/Stability_constants_of_complexes

DTPA)(2-)-enhanced MR imaging". Radiology. 205 (2): 551-8. doi:10.1148/radiology.205.2.9356644. PMID 9356644. Siversson, C; ... Delayed gadolinium-enhanced magnetic resonance imaging of cartilage or dGEMRIC measures the fixed-charge density and relative ... Transplants with 3-T Delayed Gadolinium-Enhanced MRI of Cartilage Association between findings on delayed gadolinium-enhanced ... Preliminary Results Glycosaminoglycan Distribution in Cartilage as Determined by Delayed Gadolinium-Enhanced MRI of Cartilage ( ...

https://en.wikipedia.org/wiki/Delayed_gadolinium-enhanced_magnetic_resonance_imaging_of_cartilage

... it is used as a gadolinium-based MRI contrast medium. BOPTA is a derivative of DTPA in which one terminal carboxyl group, -C(O) ... Gadobenic acid (INN, brand name Multihance) is a complex of gadolinium with the ligand BOPTA. In the form of the ... In the "gadobenate" ion gadolinium ion is 9-coordinate with BOPTA acting as an 8-coordinating ligand. The ninth position is ...

https://en.wikipedia.org/wiki/Gadobenic_acid

Second, gadolinium compounds, such as Gd-DTPA (gadopentetate dimeglumine Magnevist®), have been used routinely as contrast ... Nemoto H, Cai J, Nakamura H, Fujiwara M, Yamamoto Y (1999). "The synthesis of a carborane gadolinium-DTPA complex for boron ... January 2006). "Motexafin-gadolinium taken up in vitro by at least 90% of glioblastoma cell nuclei". Clinical Cancer Research. ... There also has been some interest in the possible use of gadolinium-157 (157Gd) as a capture agent for NCT for the following ...

https://en.wikipedia.org/wiki/Neutron_capture_therapy_of_cancer

Several polymeric gadolinium-based BPAs are currently in development but have not yet been approved for clinical use: ... Gadocoletic acid (Bracco SpA), also known as B-22956 and B22956/1, is a Gd-DTPA derivative that is currently in development, ... also known as Gd-DTPA-17, SH L 643 A. "MR Contrast Agents". 2014. Blood Pool Agents Geraldes CF, Laurent S, Classification and ...

https://en.wikipedia.org/wiki/Blood_pool_agent

... gadolinium dtpa MeSH D02.241.081.038.694.883 - technetium tc 99m pentetate MeSH D02.241.081.038.700 - peracetic acid MeSH ... gadolinium dtpa MeSH D02.092.782.590.883 - technetium tc 99m pentetate MeSH D02.092.782.677 - spermidine MeSH D02.092.782.802 ...

https://en.wikipedia.org/wiki/List_of_MeSH_codes_(D02)

... diethylenetriaminepentaacetic acid gadolinium (III) dihydrogen salt hydrate (Gd-DTPA). Like most cells, these breast cancer ... cells are much more weakly attracted by magnets than Gd-DTPA, which is an FDA-approved MRI contrast agent for use in humans. ...

https://en.wikipedia.org/wiki/Magnetic_3D_bioprinting

... is a gadolinium-based MRI contrast agent, particularly for imaging of the brain, spine and liver. It is ... Cheng KT (10 December 2007). "Gadoversetamide: Gd-DTPA-BMEA". Molecular Imaging and Contrast Agent Database (MICAD) [Internet ...

https://en.wikipedia.org/wiki/Gadoversetamide

Pentetreotide is a modified DTPA attached to a peptide segment. DTPA and derivatives are used to chelate gadolinium to form an ... DTPA improves the resolution of magnetic resonance imaging (MRI) by forming a soluble complex with a gadolinium (Gd3+) ion, ... DTPA is used in over 150 cosmetic products. DTPA is more effective than EDTA to deactivate redox-active metal ions such as Fe( ... DTPA under the form of iron(II) chelate (Fe-DTPA, 10 - 11 wt. %) is also used as aquarium plants fertilizer. The more soluble ...

https://en.wikipedia.org/wiki/Pentetic_acid

Although not required, some MRA may inject contrast agent, gadolinium, into the patient to get an enhanced image Magnetic ... pMRI requires the injection of contrast agent, usually gadopentetate dimeglumine (Gd-DTPA) into the veins in order to enhance ...

https://en.wikipedia.org/wiki/Brain_tumor

Inspired by a colleague's work in cardiac imaging, Gray worked with them and developed Delayed gadolinium-enhanced magnetic ... DTPA)(2-)-enhanced MR imaging". Radiology. 205 (2): 551-558. doi:10.1148/radiology.205.2.9356644. ISSN 0033-8419. PMID 9356644 ...

https://en.wikipedia.org/wiki/Martha_Gray

Interaction with the gadolinium (Gd) contrast agent (commonly a gadolinium ion chelate) causes the relaxation time of water ... Tofts, PS; Buckley, DL (1997). "Modeling tracer kinetics in dynamic Gd-DTPA MR imaging". Journal of Magnetic Resonance Imaging ... The common procedure for a DCE-MRI exam is to acquire a regular T1-weighted MRI scan (with no gadolinium), and then gadolinium ... Pharmacokinetic modelling of gadolinium in DCE-MRI is complex and requires choosing a model. There are a variety of models, ...

https://en.wikipedia.org/wiki/Perfusion_MRI

... motexafin gadolinium - moxifloxacin - MPNST - MRI - MRSI - MS 209 - MS-275 - mucinous carcinoma - mucosa-associated lymphoid ... tin Sn 117m DTPA - tinidazole - tioguanine - tipifarnib - tirapazamine - tissue plasminogen activator - TLK286 - TM - ...

https://en.wikipedia.org/wiki/Index_of_oncology_articles

The 2014 Ju-Jitsu World Championship were the 12th edition of the Ju-Jitsu World Championships, and were held in Paris, France from November 28 to November 30, 2014. 28.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Men's Duo System - Classic 29.11.2014 - Men's and Women's Fighting System, Men's and Women's Jiu-Jitsu (ne-waza), Women's Duo System - Classic 30.11.2014 - Men's Jiu-Jitsu (ne-waza), Mixed Duo System - Classic, Team event Vincent MATCZAK (2014-09-30). "4TH INVITAION TO WORLD CHAMPIONSHIP 2014" (PDF). Retrieved 2019-11-28.[dead link] Online results Official results (PDF) Mixed team event results (PDF) (All articles with dead external links, Articles with dead external links from April 2022, Ju-Jitsu World Championships, 2014 in French sport ...

https://en.wikipedia.org/wiki/2014_Ju-Jitsu_World_Championships

Bolley L. "Bo" Johnson (born November 15, 1951) is an American politician from the state of Florida. A member of the Democratic Party, Johnson was a member of the Florida House of Representatives, and served as the Speaker of the Florida House of Representatives. Johnson is from Milton, Florida. His father and grandfather served as county commissioners for Santa Rosa County, Florida. Johnson graduated from Milton High School, and became the first member of his family to attend college. He received his bachelor's degree from Florida State University. Johnson volunteered for Mallory Horne when Horne served as the president of the Florida Senate. At the age of 22, Johnson met Lawton Chiles, then a member of the United States Senate, who hired him as a legislative aide in 1973. Johnson was elected to the Florida House of Representatives, representing the 4th district from November 7, 1978 to November 3, 1992. He also served the 1st district from November 3, 1992 to November 8, 1994. He became the ...

https://en.wikipedia.org/wiki/Bolley_Johnson

... may refer to: Don't Say No (Billy Squier album), a 1981 album by American rock singer Billy Squier, and its title track Don't Say No (Seohyun EP), a 2016 extended play by South Korean pop singer Seohyun, and its title track "Don't Say No" (Tom Tom Club song), from the 1988 album Boom Boom Chi Boom Boom "Don't Say No", by Robbie Williams from the 2005 album Intensive Care "Don't Say No Tonight", a 1985 single by Eugene Wilde This disambiguation page lists articles associated with the title Don't Say No. If an internal link led you here, you may wish to change the link to point directly to the intended article. (Disambiguation pages with short descriptions, Short description is different from Wikidata, All article disambiguation pages, All disambiguation pages, Disambiguation pages ...

https://en.wikipedia.org/wiki/Don't_Say_No

The Dewoitine 37 was the first of a family of 1930s French-built monoplane fighter aircraft. The D.37 was a single-seat aircraft of conventional configuration. Its fixed landing gear used a tailskid. The open cockpit was located slightly aft of the parasol wing. The radial engine allowed for a comparatively wide fuselage and cockpit. Design of this machine was by SAF-Avions Dewoitine but owing to over work at that companies plant at the time, manufacture of the D.37/01 was transferred to Lioré et Olivier. They were high-wing monoplanes of all-metal construction with valve head blisters on their engine cowlings. The first prototype flew in October 1931. Flight testing resulted in the need for multiple revisions in both engine and airframe, so it was February 1934 before the second prototype flew. Its performance prompted the French government to order for 28 for the Armée de l'Air and Aéronavale. The Lithuanian government ordered 14 that remained in service with their Air Force until 1936, ...

https://en.wikipedia.org/wiki/Dewoitine_D.371

The Noor-ul-Ain (Persian: نور العين, lit. 'the light of the eye') is one of the largest pink diamonds in the world, and the centre piece of the tiara of the same name. The diamond is believed to have been recovered from the mines of Golconda, Hyderabad in India. It was first in possession with the nizam Abul Hasan Qutb Shah, later it was given as a peace offering to the Mughal emperor Aurangazeb when he defeated him in a siege. It was brought into the Iranian Imperial collection after the Persian king Nader Shah Afshar looted Delhi in the 18th century.[citation needed] The Noor-ul-Ain is believed to have once formed part of an even larger gem called the Great Table diamond. That larger diamond is thought to have been cut in two, with one section becoming the Noor-ul-Ain and the other the Daria-i-Noor diamond. Both of these pieces are currently part of the Iranian Crown Jewels. The Noor-ul-Ain is the principal diamond mounted in a tiara of the same name made for Iranian Empress Farah ...

https://en.wikipedia.org/wiki/Noor-ul-Ain

The Benoist Land Tractor Type XII was one of the first enclosed cockpit, tractor configuration aircraft built. Benoist used "Model XII" to several aircraft that shared the same basic engine and wing design, but differed in fuselage and control surfaces. The Type XII was a tractor-engined conversion of the model XII headless pusher aircraft that resembled the Curtiss pusher aircraft. Demonstration pilots used Benoist aircraft to demonstrate the first parachute jumps, and the tractor configuration was considered much more suitable for the task. The first example named the "Military Plane" had a small box frame covered fuselage that left the occupants mostly exposed to the wind. The later model XII "Cross Country Plane" had a full fuselage that occupants sat inside of. The first tractor biplane used a wooden fuselage with a small seat on top. The wings were covered with a Goodyear rubberized cloth. The first model XII was built in the spring of 1912. On 1 March 1912, Albert Berry used a headless ...

https://en.wikipedia.org/wiki/Benoist_Land_Tractor_Type_XII

... (also known as Yalmotx in Qʼanjobʼal) is a town, with a population of 17,166 (2018 census), and a municipality in the Guatemalan department of Huehuetenango. It is situated at 1450 metres above sea level. It covers a terrain of 1,174 km². The annual festival is April 29-May 4. Barillas has a tropical rainforest climate (Af) with heavy to very heavy rainfall year-round and extremely heavy rainfall from June to August. Citypopulation.de Population of departments and municipalities in Guatemala Citypopulation.de Population of cities & towns in Guatemala "Climate: Barillas". Climate-Data.org. Retrieved July 26, 2020. Muni in Spanish Website of Santa Cruz Barillas Coordinates: 15°48′05″N 91°18′45″W / 15.8014°N 91.3125°W / 15.8014; -91.3125 v t e (Articles with short description, Short description is different from Wikidata, Pages using infobox settlement with no coordinates, Articles containing Q'anjob'al-language text, Coordinates on Wikidata, ...

https://en.wikipedia.org/wiki/Santa_Cruz_Barillas

Maria Margaret La Primaudaye Pollen (10 April 1838 - c. 1919), known as Minnie, was a decorative arts collector. As Mrs John Hungerford Pollen, she became known during the early-twentieth century as an authority on the history of textiles, publishing Seven Centuries of Lace in 1908. Maria Margaret La Primaudaye was born into a Huguenot family on 10 April 1838, the third child of the Revd Charles John La Primaudaye, a descendant of Pierre de La Primaudaye. She was educated in Italy. Her family converted to Catholicism in 1851, and it was in Rome that her father met another recent English convert, John Hungerford Pollen, previously an Anglican priest and a decorative artist. She became engaged to Pollen, who was then seventeen years her senior, in the summer of 1854, and was married in the church of Woodchester monastery, near Stroud, Gloucester, on 18 September 1855. The Pollens initially settled in Dublin, where John Hungerford Pollen had been offered the professorship of fine arts at the ...

https://en.wikipedia.org/wiki/Maria_Margaret_Pollen

Ronald Robert Fogleman (born January 27, 1942) is a retired United States Air Force general who served as the 15th Chief of Staff of the Air Force from 1994 to 1997 and as Commanding General of the United States Transportation Command from 1992 to 1994. A 1963 graduate from the United States Air Force Academy, he holds a master's degree in military history and political science from Duke University. A command pilot and a parachutist, he amassed more than 6,800 flying hours in fighter, transport, tanker and rotary wing aircraft. He flew 315 combat missions and logged 806 hours of combat flying in fighter aircraft. Eighty of his missions during the Vietnam War were as a "Misty FAC" in the F-100F Super Sabre at Phù Cát Air Base, South Vietnam between 25 December 1968 and 23 April 1969. Fogleman was shot down in Vietnam in 1968, while piloting an F-100. He was rescued by clinging to an AH-1 Cobra attack helicopter that landed at the crash site. In early assignments he instructed student pilots, ...

https://en.wikipedia.org/wiki/Ronald_Fogleman

Peachtree Street" is a 1950 song co-written and recorded by Frank Sinatra in a duet with Rosemary Clooney. The song was released as a Columbia Records single. Frank Sinatra co-wrote the song with Leni Mason and Jimmy Saunders. Mason composed the music while Sinatra and Saunders wrote the lyrics. The song was arranged by George Siravo The song was released as an A side Columbia 10" 78 single, Catalog Number 38853, Matrix Number CO-43100-1 and as a 7" 33, 1-669. The B side was the re-issued "This Is the Night." Neither of the songs charted. The subject of the song is a stroll down the street in Atlanta, Georgia of the same name. Sinatra originally intended Dinah Shore to sing the duet with him. When Shore declined, Clooney was asked. The song was recorded on April 8, 1950. The song features spoken asides by Sinatra and Clooney. Rosemary Clooney asks: "Say, Frank, you wanna take a walk?" Frank Sinatra replies: "Sure, sweetie, just pick a street." He noted how there were no peach trees on the ...

https://en.wikipedia.org/wiki/Peachtree_Street_(song)

... is a painting by American illustrator Norman Rockwell that depicts a Boy Scout in full uniform standing in front of a waving American flag. It was originally created by Rockwell in 1942 for the 1944 Brown & Bigelow Boy Scout Calendar. The model, Bob Hamilton, won a contest to be in the painting and personally delivered a print to the Vice President of the United States at the time, Henry A. Wallace. The painting was created to encourage Scouts to participate in the war effort during World War II. The name of the painting, We, Too, Have a Job to Do, comes from a slogan that the Boy Scouts of America used in 1942 to rally scouts to support the troops by collecting metal and planting victory gardens. The model, Bob Hamilton, won a contest with his local council in Albany, New York, to be depicted in the painting. He traveled to Rockwell's studio in Arlington, Vermont, to model for Rockwell. Since Hamilton was a scout, the uniform shown in the painting was his, unlike some ...

https://en.wikipedia.org/wiki/We,_Too,_Have_a_Job_to_Do

At least 33[failed verification] people were killed by a fuel tanker explosion in Tleil, Akkar District, Lebanon on 15 August 2021. The disaster was reportedly exacerbated by the ongoing Lebanese liquidity crisis; in which the Lebanese pound has plummeted and fuel has been in short supply. The survivors were evacuated by the Lebanese Red Cross. An investigation is underway. The fuel tanker had been confiscated by the Lebanese Armed Forces from black marketeers, the fuel was then distributed/taken by the locals. The son of the man whose land the fuel tanker was located on, was later arrested, accused of deliberately causing the explosion. Agencies (2021-08-15). "At least 20 killed and 79 injured in fuel tank explosion in Lebanon". the Guardian. Retrieved 2021-08-15. "Lebanon fuel explosion kills 22 and injures dozens more". The Independent. 2021-08-15. Archived from the original on 2021-08-15. Retrieved 2021-08-15. "Lebanon: At least 20 dead and dozens injured after fuel tank explodes as ...

https://en.wikipedia.org/wiki/2021_Akkar_explosion

The Straubing Tigers are a professional men's ice hockey team, based in Straubing, Germany, that competes in the Deutsche Eishockey Liga. Straubing plays its home games at the Eisstadion am Pulverturm, which has a capacity of 5,800 spectators. Promoted to the DEL in 2006, and operating with one of the league's smallest budgets, the team could finish no better than twelfth before the 2011-12 DEL season, when it reached the semi-finals of the playoffs. Their greatest success so far is the qualification for the season 2020-21 of the Champions Hockey League. In 1941, the then 14-year-old Max Pielmaier and his friends Max Pellkofer and Harry Poiger founded the first hockey team in Straubing. The first official game took place on the first of February 1942 in Hof and was lost by a score of 0:1. In the following year there were several games against other Bavarian teams. The game against Landshut on 31 January. 1943 was the last game during the second World War, because the young players also had to ...

https://en.wikipedia.org/wiki/Straubing_Tigers

Dialysis patients receiving gadolinium DTPA for cardiovascular workup in conjuction with renal transplant evaluations may have ... Table 1. Demographic Data of 13 Dialysis Patients with Acute Reaction to Administration of Gadolinium-DTPA Patient. Age. Gender ... Acute Phase Reaction to Gadolinium-DTPA in Dialysis Patients. Henning Steen; Evangelos Giannitsis; Claudia Sommerer; Udo Bahner ... Cite this: Acute Phase Reaction to Gadolinium-DTPA in Dialysis Patients - Medscape - Apr 01, 2009. ...

http://www.medscape.com/viewarticle/704077

Delayed gadolinium-enhanced MR images can help define the extent of laser-induced necrosis and residual tumor after ... Gadolinium DTPA * Humans * Laser Coagulation* / instrumentation * Laser Coagulation* / methods * Laser Coagulation* / ... Conclusion: Delayed gadolinium-enhanced MR images can help define the extent of laser-induced necrosis and residual tumor after ... Gadolinium-enhanced T1-weighted three-dimensional fast low-angle shot (FLASH) MR imaging was performed before and after laser ...

https://pubmed.ncbi.nlm.nih.gov/8756910/

The process of rectal filling with 1.5-2.0 L water mixed with 15-20 mL 0.5 mol/L gadolinium-diethylenetriaminepentaacetic acid ... Gd-DTPA) was monitored with MR fluoroscopic sequence. Three-dimensional datasets of the contrast-filled colon were taken with ... patients in prone (before and after intravenous administration of 0.1 mmol/kg bodyweight Gd-DTPA) and supine positions. 64 ...

https://pubmed.ncbi.nlm.nih.gov/9142064/?dopt=Abstract

Gadolinium-DTPA enhanced MR imaging in tuberous sclerosis. Neuroradiology. 1990. 31(6):492-7. [QxMD MEDLINE Link]. ...

https://emedicine.medscape.com/article/951002-guidelines

Active lesions will enhance with gadolinium-DTPA administration. Hypointense regions on postcontrast T1-weighted scans (black ... sequencing and gadolinium-DTPA (diethylenetriaminepentaacetic acid) infusion. The MRI scan is particularly sensitive for the ... of patients with symptomatic optic neuritis are best visualized on MRI scan with fat-suppression techniques and gadolinium-DTPA ...

https://www.aao.org/bcscsnippetdetail.aspx?id=f028e716-2376-41fd-b32b-b788e825700d

Using the same sequence with fat saturation after application of gadolinium-diethylenetriamine-pentaacetic acid (T1/Gd-DTPA). ... post-gadolinium (T1/Gd-DTPA) and short tau inversion recovery (STIR) MRI sequences were used to assess chronic and active ... Using the same two MRI techniques (STIR and T1/Gd-DTPA MRI sequences) as in the present study, we found that the STIR sequence ... Performance of STIR and T1/Gd-DTPA sequences in the detection of active inflammatory spinal lesions. There was a good to very ...

https://ard.bmj.com/content/64/9/1305?ijkey=317041946090131704d4dda041508243f8f298f4&keytype2=tf_ipsecsha

Gadolinium (Gd) DTPA appears safer than iodinated contrast media.. Intravenous infusion of Gd-DTPA reliably demonstrates ... Gadolinium DTPA has promise as a contrast agent for MRI. There should be an active search for and an evaluation of other ...

https://consensus.nih.gov/1987/1987MagneticResonanceImaging066html.htm

Brain tumors: MR imaging with gadolinium-DTPA. Radiology 1985;156:681-688. ... Gd-DTPA in clinical MR of the brain: I. Intraaxial lesions. AJR Am J Roentgenol 1986;147:1223-1230. ... The effect of Gd-DTPA on T1-weighted choline signal in human brain tumours. Magn Reson Imaging 2002;20:127-130. ... Short-echo time proton MR spectroscopy in the presence of gadolinium. J Comput Assist Tomogr 2001;25:705-712. ...

http://www.ajnr.org/content/24/10/1989/tab-references

Gadolinium DTPA 20% * Hip Osteoarthritis 20% * Hip Dislocation 19% * Femur Neck 17% ...

https://portal.research.lu.se/en/persons/carl-siversson/fingerprints/

... late gadolinium enhancement (LGE) also affects prognosis. We assessed whether an ECG ri … ... Gadolinium DTPA / administration & dosage Actions. * Search in PubMed * Search in MeSH * Add to Search ... High ECG Risk-Scores Predict Late Gadolinium Enhancement on Magnetic Resonance Imaging in HCM in the Young Anna Wålinder ... High ECG Risk-Scores Predict Late Gadolinium Enhancement on Magnetic Resonance Imaging in HCM in the Young Anna Wålinder ...

https://pubmed.ncbi.nlm.nih.gov/33515326

Gadolinium DTPA Actions. * Search in PubMed * Search in MeSH * Add to Search ...

https://www.ncbi.nlm.nih.gov/pubmed/25368179&api_key=6850ce796fb3324610d4762dca788159ad08

Gadolinium-DTPA in rheumatoid arthritis and related diseases: first results with dynamic magnetic resonance imaging. Skeletal ... Contrast enhanced Gd-DTPA magnetic resonance imaging in the evaluation of rheumatoid arthritis during a clinical trial with ... Gadolinium-based contrast agents have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic ... Axial T1-weighted MR image of the wrist before and after gadolinium administration shows diffuse contrast enhancement in the ...

https://emedicine.medscape.com/article/401271-overview

Gadolinium-DTPA-enhanced saline was injected. Outcome variables included the number of control magnetic resonance images, ...

https://www.slicer.org/w/index.php?title=Main_Page/SlicerCommunity/2017&oldid=62983

The possible interaction of the gadolinium-DTPA-hormones with cultured mammary tumor cells will be measured by determining the ... For the above reasons, I propose to synthesize gadolinium-DTPA derivatives of the hormones prolactin, placental lactogen, and ... proton T1 and T2 relaxation times of the water in samples of packed tumor cells both with and without the gadolinium-DTPA ... Synthesis and Testing of Gadolinium Derivatives of Hormones. Grant Winner. *Ronald Block, Ph.D. - College of Medical Sciences ...

https://www.nova.edu/academic-affairs/faculty-research-grant/winners0203/hormones.html

MRA with gadolinium enhancement has been improved by the development of fast 3D gradient-echo sequences. The T1 shortening ... Tc-99m DTPA perfusion scintigraphy and color coded duplex sonography in the evaluation of minimal renal allograft perfusion. ... Volume model gadolinium enhanced MR angiography of pancreas-renal transplantation. The pancreas transplant (PT) is noted in the ... Volume model gadolinium enhanced MR angiography of pancreas-renal transplantation. The pancreas transplant (PT) is noted in the ...

https://emedicine.medscape.com/article/378801-overview

III: Gadolinium-based hepatobiliary contrast agents (Gd-EOB-DTPA and Gd-BOPTA/Dimeg).. Giovagnoni A; Paci E. Magn Reson Imaging ... A comparison of two MR hepatobiliary gadolinium chelates: Gd-BOPTA and Gd-EOB-DTPA.. Runge VM. J Comput Assist Tomogr; 1998; 22 ... Liver vessel enhancement by Gd-BOPTA and Gd-EOB-DTPA: a comparison in healthy volunteers.. Brismar TB; Dahlstrom N; Edsborg N; ... 3. Response to Letter: Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of ...

https://pubmedhh.nlm.nih.gov/biomarkers/search.php?id=32022384&mod=related&page=1&from=&outid=&proj=

These results were obtained by MRI,24 with specific cartilage slices, including with gadolinium-DTPA contrast agents. ... MRI was sometimes used with gadolinium-DTPA contrast agents, which can describe biomechanical and biochemical changes ...

https://www.elsevier.es/en-revista-revista-espanola-cirugia-ortopedica-traumatologia-429-articulo-osteochondral-allograft-transplantation-in-knee-S1988885621000560

Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS. ... The effect of gadolinium on the sensitivity and specificity of MR in the initial diagnosis of multiple sclerosis. Am J ... Gadolinium MRI Meta-analysis Group. Lancet 1999; 353: 964-969 * 52 Filippi M, Yousry T et al. ... Predictive value of gadolinium-enhanced magnetic resonance imaging for relapse rate and changes in disability or impairment in ...

https://www.thieme-connect.com/products/ejournals/abstract/10.1055/s-0035-1552720

Application of gadolinium-DTPA magnetic resonance imaging for detection of a filum terminale myxopapillary ependymoma allowing ...

https://jnnp.bmj.com/content/54/8

MRI shows hyperintense rim on T1 weighted images on gadolinium DTPA scan with peripheral enhancement. ...

https://dermnetnz.org/topics/tropical-pyomyositis

https://www.consensus.nih.gov/1987/1987MagneticResonanceImaging066html.htm

keywords = "Adult, Aged, Brain Neoplasms, Cell Transformation, Neoplastic, Contrast Media, Female, Gadolinium DTPA, Glioma, ... Imaging included a T(1)-weighted volume sequence before and after a double dose of Gd-DTPA contrast agent. Image data sets were ... Imaging included a T(1)-weighted volume sequence before and after a double dose of Gd-DTPA contrast agent. Image data sets were ... Imaging included a T(1)-weighted volume sequence before and after a double dose of Gd-DTPA contrast agent. Image data sets were ...

https://www.research.ed.ac.uk/en/publications/quantitative-analysis-of-whole-tumor-gd-enhancement-histograms-pr

Gadolinium DTPA,N0000006865, betamethasone sodium phosphate,N0000006864, Technetium Tc 99m Disofenin,N0000006863, Propylene ...

https://evs.nci.nih.gov/ftp1/FDA/ndfrt/Archive/structure_dn_nui.txt

Fulton, D.A., Elemento, E.M., Aime, S., Chaabane, L., Botta, M. & Parker, D. (2006). Glycoconjugates of gadolinium complexes ... Eu-EOB-DTPA. Dalton Transactions (12): 1892-1895. ... gadolinium, and europium complexes. Journal of the American ... D.L. Messeri, M.P. Parker, D. Botta & M. (2001). A stable, high relaxivity, diaqua gadolinium complex that suppresses anion and ... structure and dynamics in hydrophilic and hydrophobic gadolinium salt complexes. Dalton Transactions 47: 5605-5616. ...

https://www.dur.ac.uk/directory/profile/?id=195&publications=1

On MRI scans obtained with gadolinium diethylenetriamine pentaacetic acid (DTPA), tumors demonstrate brisk and prolonged ... T1-weighted gadolinium-enhanced magnetic resonance image (same patient as in the previous 2 images) shows a diffusely enhancing ... Gadolinium-based contrast agents have been linked to the development of nephrogenic systemic fibrosis (NSF) or nephrogenic ... T1-weighted gadolinium-enhanced magnetic resonance image (same patient as in the previous 2 images) shows a diffusely enhancing ...

https://reference.medscape.com/article/379861-overview

Values for Gadolinium-BOPTA and Gadolinium-DTPA were compared. Inter-reader agreement was evaluated. Results: Absolute T1 times ... and 30 min after administration of a bolus of 0.15mmol/kg Gadolinium-BOPTA (n=10) or Gadolinium-DTPA (n=10). T1 times were ...

https://researchfestival.nih.gov/festival11/poster-IMAG-16.html

Comparison of Gd(DTPA-BMA) (Omniscan) versus Gd(HP-DO3A) (ProHance) relative to gadolinium retention in human bone tissue by ... gadolinium-based contrast agent. GP. globus pallidus. SII. Signal Intensity Index. Gadolinium-based contrast agents (GBCAs) are ... Gadolinium Retention in the Brain: An MRI Relaxometry Study of Linear and Macrocyclic Gadolinium-Based Contrast Agents in ... Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: ...

http://www.ajnr.org/content/38/7/1311?ijkey=fa4a438463c9e47de7e5d00e15cbd7b94232d9fa&keytype2=tf_ipsecsha

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance ... Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient ... Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging. ...

https://www.ideaconnection.com/patents/medical-devices-23.html

Gadolinium DTPA Dimeglumine Gadolinium DTPA Dimeglumine Salt Gadolinium DTPA Disodium Salt Gadolinium Diethylenetriaminepenta- ... Gadolinium DTPA Disodium Salt Narrower Concept UI. M0329086. Registry Number. 92923-64-3. Terms. Gadolinium DTPA Disodium Salt ... 98; GADOLINIUM DTPA was indexed under DTPA/analogs & derivatives 1994-97, ORGANOMETALLIC COMPOUNDS 1987-97, and DTPA 1987-93; ... DTPA 1987-93. History Note. 98; use GADOLINIUM DTPA (NM) 1987-97. Date Established. 1998/01/01. Date of Entry. 1997/06/20. ...

https://meshb.nlm.nih.gov/record/ui?ui=D019786

... by using radial delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), and to assess whether pre- ... For the contrast-enhanced scan, a double dose (0.4mmol/kg) of the gadolinium-based contrast agent Magnevist (Gd-DTPA2-, ... Burstein D, Velyvis J, Scott KT, Stock KW, Kim YJ, Jaramillo D, Boutin RD, Gray ML: Protocol issues for delayed Gd(DTPA)(2-)- ... Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a minimally invasive technique to assess the ...

https://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/1471-2474-13-212

In the present study HSA nanoparticles were conjugated with gadolinium diethylenetriamine- pentaacetic acid (Gd-DTPA) using carbodiimide chemistry. (au.edu)
The dynamic curve showed high percent signal intensity (200%) at first passage after administration of gadolinium-diethylenetriamine pentaacetic acid (Gd- DTPA) and plateau-type morphology. (unicatt.it)

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid ( DTPA see PENTETIC ACID ), that is given to enhance the image in cranial and spinal MRIs. (bvsalud.org)
To investigate value of magnetic resonance cholangiopancreatography (MRCP) using oral diluted gadolinium (Gd)-diethylenetriamine penta-acetic acid (DTPA) as negative contrast materials in diagnosis of juxtapapillary duodenal diverticulum with atypical imaging features. (clinicalimaging.org)

Plain and gadolinium-DTPA-enhanced MR imaging of hepatocellular carcinoma treated with transarterial chemoembolization. (unimib.it)

After an intravenous bolus injection of gadolinium-diethylenetriaminepentaacetic acid, 20 consecutive fast spin-echo axial images of the wrist were obtained every 18 s. (biomedcentral.com)
1T) magnets that enabled spectral fat-suppression, new methods of k-space filling to increase resolution and speed, and bolus injection of gadolinium dimeglumine created the technique of dynamic contrast-enhanced breast MRI. (medscape.com)

Axillary, popliteal, and iliac lymph nodes and each injection site were assayed for radioactivity at 1 and 3 h after injection of approximately 3.7 MBq (0.050 mL) 99m Tc-DTPA-mannosyl-dextran (0.22 nmol) or filtered 99m Tc-sulfur colloid into the foot pads. (snmjournals.org)
99m Tc-DTPA-mannosyl-dextran exhibited significantly faster injection site clearance than did filtered 99m Tc-sulfur colloid. (snmjournals.org)
99m Tc-DTPA-mannosyl-dextran is a receptor-based sentinel node radiotracer that exhibits the desired properties of rapid injection site clearance and low distal node accumulation. (snmjournals.org)
5 Extra-articular injection of the dilute gadolinium chelate solution is a common iatrogenic complication of MRA. (jaocr.org)
For measuring the infarct size in humans, cardiac MR (cMR) after injection of Gadolinium contrast agents is currently considered the reference standard [1]. (heraldopenaccess.us)

When breast MRI is performed for screening or evaluation of breast cancer, administration of an intravenous gadolinium-based contrast agent is a must. (medscape.com)
Sixteen patients with suspected cerebral metastases were studied with magnetic resonance (MR) imaging before and after the intravenous administration of 0.1 mmol/kg of gadolinium diethylenetriaminepentaacetic acid. (northwestern.edu)

We report the synthesis and preliminary biologic testing of a synthetic macromolecule, 99m Tc-diethylenetriaminepentaacetic acid (DTPA)-mannosyl-dextran, for sentinel node detection. (snmjournals.org)
Amino, mannose, and DTPA densities were measured by trinitrobenzene sulfonate assay, sulfuric acid/phenol assay, and inductively coupled plasma spectroscopy of gadolinium-DTPA-mannosyl-dextran, respectively. (snmjournals.org)
The authors present 2 cases with ruptured microaneurysms, in which 3-dimensional (3D) fast spin-echo T1 imaging with variable flip angles (CUBE T1) using gadolinium-diethylenetriaminepentaacetic acid (Gd) enhancement was useful in diagnosing the microaneurysms as the source of bleeding. (elsevier.com)
A system comprising a primary amine organic extractant and an aqueous eluent containing diethylenetriaminepentaacetic acid (dtpa) was less effective for separating the rare earths. (cdc.gov)

The agent is a prolonged circulating gadolinium containing macromolecule that consists of a monomethoxy ether of polyethylene glycol attached to poly L lysine?Gd DTPA. (alksignaling.com)

Imaging with Mn-DPDP resulted in the highest intensity enhancement of the liver compared with Cr-DEHIDA and Gd-DTPA. (lu.se)
First-pass and delayed enhancement MRI was obtained after i.v administration of Gadolinium-DTPA. (uniroma1.it)

DTPA-mannosyl-dextran had a molecular weight of 35,800 g/mol and a molecular diameter of 7.1 nm. (snmjournals.org)
0.05) higher for 99m Tc-DTPA-mannosyl-dextran (90.1% ± 10.7% and 97.7% ± 2.0%, respectively) than for filtered 99m Tc-sulfur colloid (78.8 ± 6.5 and 67.4% ± 26.8%, respectively). (snmjournals.org)
The 99m Tc-DTPA-mannosyl-dextran percentage injected dose (%ID) for the front and rear paws was 52.6 ± 10.5 and 52.3 ± 8.0 at 1 h and 45.7 ± 8.5 and 43.6 ± 8.2 at 3 h after administration. (snmjournals.org)
The contrast agent used in MRI scans is typically a substance called Gadolinium (Gd) that has been ligand bound to another agent (either DTPA, albumin, dextran or other agents). (kitta.net)

Two liver-specific MRI contrast media, Cr-DEHIDA and Mn-DPDP, and the nonspecific agent Gd-DTPA were studied in normal rats and in rats whose bile ducts had been ligated before administration of the contrast medium. (lu.se)

After oral administration of diluted Gd-DTPA, they disappeared at MRCP. (clinicalimaging.org)

CONCLUSIONS: In these thirty patients of obstructive uropathy, low magnetic field, open MRI units and low-dose Gd-DTPA provided cost-effective MRU studies with excellent diagnostic utility. (who.int)
METHODS: 29 knees (19 men/10 women) were prospectively examined by repeat delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), approximately 3 weeks and 2.3±1.3 (range 4.5) years after the injury. (bibbase.org)

Mixed liposomes, obtained by coaggregation of 1,2-dioleoyl-sn-glycero-3-phosphocholine and of the synthetic monomer containing a gadolinium complex ([C18] 2 DTPA[Gd]) have been prepared. (dovepress.com)

The MRI agent requires a high density of attachment sites for gadolinium delivery to the limited number of hepatocyte receptors. (snmjournals.org)
Not least of the developments in MRI techniques has been the introduction of a contrast agent, gadolinium-DTPA (Gd), which allows direct visualization of damage to the BBB. (discectomy.net)

Top left) Gadolinium-enhanced T1-weighted MRI demonstrates an ill-defined low-signal-intensity mass. (medscape.com)

Three months later, some high-signal areas on T2-weighted scans had decreased in size to resemble the areas previously outlined by Gd-DTPA. (edu.au)

MRCP using oral Gd-DTPA as negative contrast materials can be helpful in obtaining definitive diagnosis of those juxtapapillary duodenal diverticula without typical imaging features. (clinicalimaging.org)

Neodymium, samarium, and gadolinium were separated by a liquid- liquid chromatographic technique. (cdc.gov)

Nineteen patients with juxtapapillary duodenal diverticula of which imaging findings were atypical underwent MRCP using oral diluted Gd-DTPA as negative contrast materials after conventional MRCP without any oral contrast materials. (clinicalimaging.org)

Three-dimensional datasets of the contrast-filled colon were taken with patients in prone (before and after intravenous administration of 0.1 mmol/kg bodyweight Gd-DTPA) and supine positions. (nih.gov)
T 1 -weighted and proton density-weighted spoiled gradient-echo breath-hold images (2D-FLASH) were obtained before and after the administration of Gd-DTPA in a standard dosage of 0.1 mmol/kg body weight. (elsevier.com)
LGE-CMR (Gadolinium-DTPA:0.2 mmol/kg, Magnevist) was performed and analyzed by two experienced blinded observers. (biomedcentral.com)
After revascularization, a representative slice was analyzed 14 +/- 1 min after injection of 0.1 mmol/kg Gd-DTPA using a T1-weighted turbo fast low-angle shot sequence. (ox.ac.uk)
Every 4 weeks for 3 months, dual-echo and postcontrast T1-weighted (5 min after the injection of 0.3 mmol/kg gadolinium-DTPA) scans were obtained from 28 patients with relapsing-remitting MS. New lesions were defined as those present on dual-echo and/or postcontrast T1-weighted scans but with no corresponding MRI abnormalities on any of the preceding scans. (wroc.pl)
동물실험에서는 체중 2.5kg의 건강한 토끼 5 마리를 대상으로 하여 Gd-DTPA를 0.2mL/sec, 0.4mL/sec의 주입속도, 0.25mmol/mL, 0.5mmol/mL의 주입농도, 5mL, 10mL 의 주입량으로 주입변수를 변화시키면서 단일주입방법으로 주입하였다. (ewha.ac.kr)
주입변수의 변화에 따라 흡수감약계수의 최고치가 가장 높아지고 최고점에 도달하는 시간도 가잘 짧아지는 경우는 Gd-DTPA 의 주입량이 일정한 조건 하에서 주입속도를 0.4mL/sec, 주입농도를 0.5mmol/mL로 하였을 때였으며, 이때 주입량을 10mL로 하면 iopromide와 가장 유사한 양상의 시간-조영증강 곡선을 나타내었다. (ewha.ac.kr)

Compared with the commercially available Gd-DTPA (Magnevist), Fe 2 O 3 @BSA nanoparticles have brighter signal and longer angiographic effect, indicating a great potential as a T 1 contrast agent in steady-state and high-resolution MR imaging. (cas.cn)
Recently, we developed novel chiral dendrimer-triamine-coordinated Gd-MRI contrast agents (Gd-MRI CAs), which showed longitudinal relaxivity (r1) values about four times higher than that of clinically used Gd-DTPA (Magnevist®, Bayer). (kyoto-u.ac.jp)

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid ( DTPA see PENTETIC ACID ), that is given to enhance the image in cranial and spinal MRIs. (nih.gov)

Consequently, the FDA revised its class warnings for all gadolinium-based contrast media and advised that the use of gadolinium-contrast agents must be based on careful consideration. (thefreelibrary.com)

Here we report an acute phase reaction to at least one of the Gd compounds used for MRI investigation, i.e. diethylenetriamine penta-acetic acid (Gd-DTPA). (medscape.com)
The process of rectal filling with 1.5-2.0 L water mixed with 15-20 mL 0.5 mol/L gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA) was monitored with MR fluoroscopic sequence. (nih.gov)
Some of these strategies also make use of variations that represent evolving technologies, such as the use of liver-specific MRI contrast agents such as gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) and superparamagnetic iron oxide (SPIO), dual energy CT, and newer fluorodeoxyglucose positron emission tomography (FDG-PET) tracers such as 18 F-fluorothymidine (FLT), 11 C-choline, and 11 C-methionine. (ahrq.gov)
A system comprising a primary amine organic extractant and an aqueous eluent containing diethylenetriaminepentaacetic acid (dtpa) was less effective for separating the rare earths. (cdc.gov)

Gadolinium-Ethoxybenzyl (EOB)-DTPA, a new liver-specific MR contrast agent. (insa-lyon.fr)

To address this problem, paramagnetic gadolinium diethylenetriaminepentaacetic acidity (Gd-DTPA) conjugated to Sialyl Lewis X (Slex) was designed. (perlierusa.com)
Gadolinium 은 상자성(paramagnetic properties) 때문에 주로 MRI 조영제로 널리 알려져 있으나, 높은 원자번호와 기존의 CT 조영제인 iodine 조영제와 유사한 약물동력작용(pharmacokinetics)을 갖는 특성을 고려해 보면 CT 조영제로의 사용 가능성을 착안할 수 있다. (ewha.ac.kr)

6. Differentiating focal nodular hyperplasia from hepatocellular adenoma: Is hepatobiliary phase MRI (HBP-MRI) using linear gadolinium chelates always useful? (nih.gov)
15. A comparison of two MR hepatobiliary gadolinium chelates: Gd-BOPTA and Gd-EOB-DTPA. (nih.gov)
MRI contrast agents, including gadolinium (III) chelates and superparamagnetic iron oxide nanoparticles (SIONPs), are introduced to achieve a higher resolution and enhance the signal intensity by altering the relaxation times of surrounding water protons. (sigmaaldrich.com)
2 Gadolinium(III) chelates are effective T1 contrast agents because they shorten the longitudinal relaxation rate (T1) and increase positive contrast on T1-weighted MRI sequences. (sigmaaldrich.com)

We describe a standard set of quantity names and symbols related to the estimation of kinetic parameters from dynamic contrast-enhanced T(1)-weighted magnetic resonance imaging data, using diffusable agents such as gadopentetate dimeglumine (Gd-DTPA). (bioseek.eu)

We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and globus pallidus and any associations with cognitive function in multiple sclerosis. (ajnr.org)
Diagnosis of multiple sclerosis (MS) currently requires lesion identification by gadolinium (Gd)-enhanced or T(2)-weighted magnetic resonance imaging (MRI). (ox.ac.uk)
Detecting new lesion formation in multiple sclerosis: the relative contributions of monthly dual-echo and T1-weighted scans after triple-dose gadolinium. (wroc.pl)
Short-term evolution of new multiple sclerosis lesions enhancing on standard and triple dose gadolinium-enhanced brain MRI scans. (wroc.pl)

T 1 weighted spin echo pre -(T 1 ), post-gadolinium (T 1 /Gd-DTPA) and short tau inversion recovery (STIR) MRI sequences were used to assess chronic and active spinal lesions using the scoring system ASspiMRI. (bmj.com)

8. Washout appearance in Gd-EOB-DTPA-enhanced MR imaging: A differentiating feature between hepatocellular carcinoma with paradoxical uptake on the hepatobiliary phase and focal nodular hyperplasia-like nodules. (nih.gov)
12. OATPB1/B3 and MRP3 expression in hepatocellular adenoma predicts Gd-EOB-DTPA uptake and correlates with risk of malignancy. (nih.gov)
Paradoxical uptake of Gd-EOB-DTPA on the hepatobiliary phase in the evaluation of hepatic metastasis from breast cancer: Is the 'target sign' a common finding? (elsevier.com)

3. Response to Letter: Intrapatient Comparison of the Hepatobiliary Phase of Gd-BOPTA and Gd-EOB-DTPA in the Differentiation of HCA From FNH. (nih.gov)

Health care professionals should consider the retention characteristics of each agent when choosing a GBCA for patients who may be at higher risk for gadolinium retention. (thefreelibrary.com)
Well-conducted long-term animal studies demonstrated that for linear GBCA, a large portion of gadolinium was retained in the brain, with binding of soluble gadolinium to macromolecules. (jbsr.be)
Many feel competent enough to offer their humble opinion about gadolinium-based contrast agents (GBCA), not only radiologists and physicians of every shade and color, but also physicists and chemists, as well as want-to-be experts such as journalists and movie actors. (rinckside.org)
To ensure volunteers who have renal failure do not undergo a GBCA imaging study, all volunteers who will receive Gadolinium based contrast agents will have a serum Creatinine obtained within one week of the MRI examination. (nih.gov)

In this study, the membranous and osseous labyrinths of the wild type mouse inner ear were examined using volumetric data from ultra high-field magnetic resonance imaging (MRI) with gadolinium contrast at 9.4 Tesla and high-resolution micro-computed tomography (µCT) to visualize the scalae and vestibular apparatus, and to establish imaging protocols and parameters for comparative analysis of the normal and mutant mouse inner ear. (openneuroimagingjournal.com)

Delayed gadolinium-enhanced MR images can help define the extent of laser-induced necrosis and residual tumor after interstitial laser photocoagulation therapy in breast cancer. (nih.gov)
The possible interaction of the gadolinium-DTPA-hormones with cultured mammary tumor cells will be measured by determining the proton T1 and T2 relaxation times of the water in samples of packed tumor cells both with and without the gadolinium-DTPA complexed to the various hormones, and bound to the cells. (nova.edu)
Shiga, H. / Magnetic resonance imaging of bladder tumors : superiority of serial "Fast SE" assisted by Gd-DTPA in tumor staging . (elsevier.com)
How small of a tumor (mm) can a 3-Tesla MRI detect without gadolinium contrast? (rinckside.org)
There are many patents for magnetic nanoparticles as tumor magnetic resonance imaging enhancers, but the gadolinium complexes commonly used in the clinic are difficult to target the diseased tissues, while nanoliposomes are ideal carriers for anti-tumor drugs. (peertechzpublications.com)

Gadolinium based contrast agent (Gd-DTPA), which is commonly used in clinic, may release a small amount of free Gd ions in vivo, resulting in serious toxicities and side effects, while iron oxide nanoparticles with ultra-small size (less than 5 nm) have good biocompatibility and are considered to be an ideal substitute for gadolinium based contrast agents. (cas.cn)

To date, the only known adverse health effect related to gadolinium retention is a rare condition called nephrogenic systemic fibrosis (NSF) that occurs in a small subgroup of patients with pre-existing kidney failure. (rinckside.org)

Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. (ajnr.org)
A causal association between these adverse events and gadolinium retention could not be established. (rinckside.org)

For the above reasons, I propose to synthesize gadolinium-DTPA derivatives of the hormones prolactin, placental lactogen, and oxytocin. (nova.edu)

Among, magnetic nanoparticles have been used as magnetic resonance imaging agents, For example, Li Xiaojuan's team of Chongqing Medical University proposed the preparation method of magnetic resonance developer of chitosan coated Fe3O4 magnetic nanoparticles [6], in addition, the preparation method of gadolinium loaded chitosan nanoparticles as magnetic resonance imaging contrast agent proposed by Zhang Li of Shandong University [7]. (peertechzpublications.com)

Liquid-liquid chromatographic separation of neodymium, samarium, and gadolinium. (cdc.gov)
Neodymium, samarium, and gadolinium were separated by a liquid- liquid chromatographic technique. (cdc.gov)
Recovery of 45 percent of the neodymium as >90 percent nd2o3, 84 percent of the samarium as >99 percent sm2o3, and 50 percent of the gadolinium as >99 percent gd2o3 was achieved. (cdc.gov)

However, there are some problems in these disclosed preparation methods of developer, for example, biocompatibility is not high, it is easily engulfed by macrophages, it does not have ideal internal circulation characteristics in blood, it is not easy to accumulate in specific tissues, at the same time, gadolinium complexes commonly used in clinic are usually toxic, and it is difficult to enter the lesion cells [8-10]. (peertechzpublications.com)

abstract = "Objective: The aim of this study was to retrospectively analyze the outcome of LR-3 and LR-4 without arterial phase hyperenhancement (APHE), and identify which features could predict LR-5 progression on serial Gd-EOB-DTPA-enhanced MRI follow-up. (unipa.it)

One of the biggest problems is that increased SI ratios at unenhanced T 1 -weighted MRI are a poor biomarker for gadolinium deposition, as SI ratios do not have a linear relationship with Gd concentration, and are highly dependent on the magnetic resonance imaging (MRI) parameters used during acquisition. (jbsr.be)
After three MRI examinations five years ago, Norris and his wife Gena claim that she now has "gadolinium deposition disease" and, according to an article in the U.S. news magazine Newsweek, are suing for $10 million in damages, first and foremost directed at Bracco. (rinckside.org)
The term "gadolinium deposition disease" was introduced by Dr. Richard C. Semelka in 2016. (rinckside.org)
Semelka also proposed the application of Ca-DTPA and Zn-DTPA to reduce or eliminate gadolinium deposition disease symptoms. (rinckside.org)

The contrast agent used in MRI scans is typically a substance called Gadolinium (Gd) that has been ligand bound to another agent (either DTPA, albumin, dextran or other agents). (kitta.net)
Multipurpose gadolinium-based ligand DO3A-EA as precursor for conjugation with organic molecules to develop smart and targeted contrast agents for MR and optical imaging. (mpg.de)

The purpose of the present study was to investigate the radial distribution patterns of cartilage degeneration in dysplastic hips at different stages of secondary osteoarthritis (OA) by using radial delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), and to assess whether pre-contrast measurements are necessary. (biomedcentral.com)

Brain tumors: MR imaging with gadolinium-DTPA. (ajnr.org)

and because these gadolinium contrast agents pass the blood-brain barrier, increased awareness has focused on their toxicity. (thefreelibrary.com)
6 ] It's a syndrome whose symptoms are headache, cognitive disturbance, skin hyperpigmentation, and arthralgia - which according to the authors are clinical manifestations of presumed gadolinium toxicity in patients with normal renal function. (rinckside.org)

5. [Gd-EOB-DTPA-enhanced magnetic resonance imaging: differentiation between focal nodular hyperplasia and hepatocellular adenoma]. (nih.gov)

Several late sequelae of the administration of gadolinium (Gd)-containing MRI contrast agents have been described in patients with advanced renal failure. (medscape.com)
In an observational series, we found a remarkable frequency of peracute reactions after administration of Gd-DTPA used for cardiovascular evaluation before renal transplantation. (medscape.com)

In a 26-month observational period, 13 of 136 haemodialyzed or CAPD patients exhibited onset of fever, chills and nausea within hours after administration of Gd-DTPA peracute. (medscape.com)
Cite this: Acute Phase Reaction to Gadolinium-DTPA in Dialysis Patients - Medscape - Apr 01, 2009. (medscape.com)
The Signal Intensity Index in the dentate nucleus and globus pallidus was retrospectively evaluated on T1-weighted MR imaging in an 18-year longitudinal cohort study of 23 patients with MS receiving multiple gadolinium-based contrast agent administrations and 23 healthy age- and sex-matched controls. (ajnr.org)
The method of examination included precontrast and gadolinium(Gd)-enhanced MRI in 72 and plain MRI in 14 patients. (edu.au)
Gadolinium-based contrast agents (GBCAs) increase the risk for NSF among patients with impaired elimination of the drugs. (nih.gov)
Cimmino MA, Innocenti S, Livrone F, Magnaguagno F, Silvestri E, Garlaschi G. Dynamic gadolinium-enhanced magnetic resonance imaging of the wrist in patients with rheumatoid arthritis can discriminate active from inactive disease. (ia-grp.com)

According to information from the European Medicines Agency (EMA) and the Federal Institute for Drugs and Medical Devices (January 2018), the long-term risks of gadolinium contrast agent administration are still unknown. (thefreelibrary.com)

Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a minimally invasive technique to assess the biochemical properties of articular cartilage. (biomedcentral.com)
The intravenously injected anionic contrast agent gadopentetate (Gd-DTPA 2- ) distributes in cartilage inversely to the concentration of negatively charged glycosaminoglycans (GAGs). (biomedcentral.com)

Gd-DTPA in clinical MR of the brain: I. Intraaxial lesions. (ajnr.org)

Sequences used were spin echo (TR/TE (msec) = 500/20 as T1WI (weighted image) and 1500/80 as T2WI) and serial "fast spin echo (fast SE)" pre/post Gd-DTPA administration. (elsevier.com)
Evaluating signal intensity of movement-impaired myocardial segments in MR delayed images after administration of Gd-DTPA. (ox.ac.uk)
Agencies such as the EMA and the U.S. Food and Drug Administration (FDA) differ in regulating the use of gadolinium-based contrast agents. (rinckside.org)

Gadolinium is retained for months or years in brain, bone, and other organs. (nih.gov)

Facile Synthesis of Gd-DO3A-EA Conjugated with DTPA: A Novel Calcium Dependent MR Contrast Agent. (mpg.de)

Anatomy7

Organisms1

Diseases11

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Phenomena and Processes10

Disciplines and Occupations1

Information Science2

Health Care3

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI. (1/1258)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1258)

A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. (3/1258)

Statistical power of MRI monitored trials in multiple sclerosis: new data and comparison with previous results. (4/1258)

Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits. (5/1258)

Cell water balance of white button mushrooms (Agaricus bisporus) during its post-harvest lifetime studied by quantitative magnetic resonance imaging. (6/1258)

Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. (7/1258)

Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (8/1258)

Gadolinium

Gadolinium DTPA

Pentetic Acid

Contrast Media

Organometallic Compounds

Nephrogenic Fibrosing Dermopathy

Technetium

Magnetic Resonance Imaging

Indium

Magnetic Resonance Imaging, Cine

Americium

Indium Radioisotopes

Meglumine

Heterocyclic Compounds

Iodohippuric Acid

Metalloporphyrins

Chelating Agents

Radioisotope Renography

Edema, Cardiac

Ytterbium

Image Enhancement

Tissue Distribution

Magnetic Resonance Angiography

Heterocyclic Compounds, 1-Ring

Aerosols

Radiopharmaceuticals

Isotope Labeling

Tin Radioisotopes

Perilymph

Kupffer Cells

Fibrosis

Cicatrix

Sensitivity and Specificity

Predictive Value of Tests

Time Factors

Myocardium

Radiochemistry

Breath Holding

Gallium Radioisotopes

Cisterna Magna

Cardiomyopathies

Spectroscopy, Electron Energy-Loss

Radioactivity

Hypertension, Renovascular

Radioimmunotherapy

Cardiomyopathy, Hypertrophic

Convection

Subarachnoid Space

Ferrosoferric Oxide

Image Interpretation, Computer-Assisted

Reproducibility of Results

Metabolic Clearance Rate

Injections, Intravenous

Brain Neoplasms

Intracranial Hypotension

Myocardial Perfusion Imaging

Iohexol

Calcium Ionophores

Renal Artery Obstruction

Skin Diseases

Edetic Acid

Organotechnetium Compounds

Mucociliary Clearance

Lanthanoid Series Elements

Stroke Volume

Mechanoreceptors

Iodine Radioisotopes

Triacetoneamine-N-Oxyl

Dogs

Succimer

Phantoms, Imaging

Staging and monitoring of malignant lymphoma of the bone: comparison of 67Ga scintigraphy and MRI. (1/1258)

Extradural inflammation associated with annular tears: demonstration with gadolinium-enhanced lumbar spine MRI. (2/1258)

A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. (3/1258)

Statistical power of MRI monitored trials in multiple sclerosis: new data and comparison with previous results. (4/1258)

Correlation of histological findings with gadolinium enhanced MRI scans during healing of a PHEMA orbital implant in rabbits. (5/1258)

Cell water balance of white button mushrooms (Agaricus bisporus) during its post-harvest lifetime studied by quantitative magnetic resonance imaging. (6/1258)

Cervical epidural lipoblastomatosis: changing MR appearance after chemotherapy. (7/1258)

Neurocutaneous melanosis presenting with intracranial amelanotic melanoma. (8/1258)

Comparison of triple dose versus standard dose gadolinium-DTPA for detection of MRI enhancing lesions in patients with MS -...

$T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction...$ T1 mapping of the myocardium: intra-individual assessment of post-contrast T1 time evolution and extracellular volume fraction...