Fusobacterium: A genus of gram-negative, anaerobic, rod-shaped bacteria found in cavities of humans and other animals. No endospores are formed. Some species are pathogenic and occur in various purulent or gangrenous infections.Fusobacterium Infections: Infections with bacteria of the genus FUSOBACTERIUM.Fusobacterium nucleatum: A species of gram-negative, anaerobic, rod-shaped bacteria isolated from the gingival margin and sulcus and from infections of the upper respiratory tract and pleural cavity.Fusobacterium necrophorum: A species of gram-negative, non-spore-forming bacteria isolated from the natural cavities of man and other animals and from necrotic lesions, abscesses, and blood.Bacteria, AnaerobicBacteroides: A genus of gram-negative, anaerobic, rod-shaped bacteria. Its organisms are normal inhabitants of the oral, respiratory, intestinal, and urogenital cavities of humans, animals, and insects. Some species may be pathogenic.Bacteroidaceae: A family of gram-negative bacteria found primarily in the intestinal tracts and mucous membranes of warm-blooded animals. Its organisms are sometimes pathogenic.Porphyromonas: A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods or coccobacilli. Organisms in this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings indicated the need to separate them from other Bacteroides species, and hence, this new genus was created.Veillonella: A genus of gram-negative, anaerobic cocci parasitic in the mouth and in the intestinal and respiratory tracts of man and other animals.Peptostreptococcus: A genus of gram-positive, anaerobic, coccoid bacteria that is part of the normal flora of humans. Its organisms are opportunistic pathogens causing bacteremias and soft tissue infections.Lemierre Syndrome: A superinfection of the damaged oropharyngeal mucosa by FUSOBACTERIUM NECROPHORUM leading to the secondary septic THROMBOPHLEBITIS of the internal jugular vein.Liver Abscess: Solitary or multiple collections of PUS within the liver as a result of infection by bacteria, protozoa, or other agents.Prevotella intermedia: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium is a common commensal in the gingival crevice and is often isolated from cases of gingivitis and other purulent lesions related to the mouth.Mouth: The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.Bacteria, AerobicPeriodontitis: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)Eubacterium: A genus of gram-positive, rod-shaped bacteria found in cavities of man and animals, animal and plant products, infections of soft tissue, and soil. Some species may be pathogenic. No endospores are produced. The genus Eubacterium should not be confused with EUBACTERIA, one of the three domains of life.Actinomyces: A genus of gram-positive, rod-shaped bacteria whose organisms are nonmotile. Filaments that may be present in certain species are either straight or wavy and may have swollen or clubbed heads.Gingiva: Oral tissue surrounding and attached to TEETH.Noma: A severe gangrenous process occurring predominantly in debilitated and malnourished children, especially in underdeveloped countries. It typically begins as a small vesicle or ulcer on the gingiva that rapidly becomes necrotic and spreads to produce extensive destruction of the buccal and labial mucosa and tissues of the face, which may result in severe disfigurement and even death. Various bacteria have been implicated in the etiology. (Dorland, 27th ed)Prevotella: A genus of gram-negative, anaerobic, nonsporeforming, nonmotile rods. Organisms of this genus had originally been classified as members of the BACTEROIDES genus but overwhelming biochemical and chemical findings in 1990 indicated the need to separate them from other Bacteroides species, and hence, this new genus was established.Abscess: Accumulation of purulent material in tissues, organs, or circumscribed spaces, usually associated with signs of infection.Dental Plaque: A film that attaches to teeth, often causing DENTAL CARIES and GINGIVITIS. It is composed of MUCINS, secreted from salivary glands, and microorganisms.Periodontal Diseases: Pathological processes involving the PERIODONTIUM including the gum (GINGIVA), the alveolar bone (ALVEOLAR PROCESS), the DENTAL CEMENTUM, and the PERIODONTAL LIGAMENT.Bacteroides Infections: Infections with bacteria of the genus BACTEROIDES.Porphyromonas gingivalis: A species of gram-negative, anaerobic, rod-shaped bacteria originally classified within the BACTEROIDES genus. This bacterium produces a cell-bound, oxygen-sensitive collagenase and is isolated from the human mouth.Anaerobiosis: The complete absence, or (loosely) the paucity, of gaseous or dissolved elemental oxygen in a given place or environment. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)Halitosis: An offensive, foul breath odor resulting from a variety of causes such as poor oral hygiene, dental or oral infections, or the ingestion of certain foods.Bacteria: One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.Periapical Abscess: Acute or chronic inflammation of tissues surrounding the apical portion of a tooth, associated with the collection of pus, resulting from infection following pulp infection through a carious lesion or as a result of an injury causing pulp necrosis. (Dorland, 27th ed)Gram-Negative Anaerobic Bacteria: A large group of anaerobic bacteria which show up as pink (negative) when treated by the Gram-staining method.Bacteroides fragilis: Gram-negative bacteria occurring in the lower intestinal tracts of man and other animals. It is the most common species of anaerobic bacteria isolated from human soft tissue infections.Bacteroidaceae Infections: Infections with bacteria of the family BACTEROIDACEAE.Bites, Human: Bites inflicted by humans.RNA, Ribosomal, 16S: Constituent of 30S subunit prokaryotic ribosomes containing 1600 nucleotides and 21 proteins. 16S rRNA is involved in initiation of polypeptide synthesis.Foot Rot: A disease of the horny parts and of the adjacent soft structures of the feet of cattle, swine, and sheep. It is usually caused by Corynebacterium pyogenes or Bacteroides nodosus (see DICHELOBACTER NODOSUS). It is also known as interdigital necrobacillosis. (From Black's Veterinary Dictionary, 18th ed)Clindamycin: An antibacterial agent that is a semisynthetic analog of LINCOMYCIN.Lung Abscess: Solitary or multiple collections of PUS within the lung parenchyma as a result of infection by bacteria, protozoa, or other agents.Streptococcus: A genus of gram-positive, coccoid bacteria whose organisms occur in pairs or chains. No endospores are produced. Many species exist as commensals or parasites on man or animals with some being highly pathogenic. A few species are saprophytes and occur in the natural environment.Actinomycosis: Infections with bacteria of the genus ACTINOMYCES.Bacterial Infections: Infections by bacteria, general or unspecified.Species Specificity: The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species.Streptococcus oralis: A species of gram-positive, coccoid bacteria that is numerous in the mouth and throat. It is a common cause of endocarditis and is also implicated in dental plaque formation.Aggregatibacter actinomycetemcomitans: A species of Gram-negative, facultatively anaerobic spherical or rod-shaped bacteria indigenous to dental surfaces. It is associated with PERIODONTITIS; BACTERIAL ENDOCARDITIS; and ACTINOMYCOSIS.Treponema denticola: A species of bacteria in the family SPIROCHAETACEAE, frequently isolated from periodontal pockets (PERIODONTAL POCKET).Metronidazole: A nitroimidazole used to treat AMEBIASIS; VAGINITIS; TRICHOMONAS INFECTIONS; GIARDIASIS; ANAEROBIC BACTERIA; and TREPONEMAL INFECTIONS. It has also been proposed as a radiation sensitizer for hypoxic cells. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985, p133), this substance may reasonably be anticipated to be a carcinogen (Merck, 11th ed).Leptothrix: A genus of gram-negative, sheathed, rod-shaped bacteria in the family COMAMONADACEAE.Streptococcus gordonii: A species of gram-positive, facultatively anaerobic bacteria in the family STREPTOCOCCACEAE. It is a normal inhabitant of the human oral cavity, and causes DENTAL PLAQUE and ENDOCARDITIS. It is being investigated as a vehicle for vaccine delivery.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Clostridium: A genus of motile or nonmotile gram-positive bacteria of the family Clostridiaceae. Many species have been identified with some being pathogenic. They occur in water, soil, and in the intestinal tract of humans and lower animals.Streptococcus sanguis: A gram-positive organism found in dental plaque, in blood, on heart valves in subacute endocarditis, and infrequently in saliva and throat specimens. L-forms are associated with recurrent aphthous stomatitis.Bacterial Adhesion: Physicochemical property of fimbriated (FIMBRIAE, BACTERIAL) and non-fimbriated bacteria of attaching to cells, tissue, and nonbiological surfaces. It is a factor in bacterial colonization and pathogenicity.EsculinMicrobial Interactions: The inter- and intra-relationships between various microorganisms. This can include both positive (like SYMBIOSIS) and negative (like ANTIBIOSIS) interactions. Examples include virus - bacteria and bacteria - bacteria.
Bovine polymorphonuclear neutrophil-mediated phagocytosis and an immunoglobulin G2 protease produced by Porphyromonas levii. (1/297)
Acute interdigital phlegmon (AIP) is a commonly occurring anaerobic bacterial infection in cattle. This study examined in vitro the interaction of bovine polymorphonuclear granulocytic neutrophils (PMN) from blood with bacterial species involved in AIP. Polymorphonuclear neutrophils were purified from whole bovine blood, exposed to one of the three putative etiologic agents of AIP and comparatively assessed for phagocytosis using light microscopy. Fusobacterium necrophorum and Prevotella intermedia were effectively phagocytosed by PMN, but Porphyromonas levii was phagocytosed significantly less effectively by PMN. The effect of high titre anti-P. levii bovine serum on antibody-mediated phagocytosis by PMN was also evaluated. High titre serum increased the efficiency of phagocytosis of P. levii by bovine PMN. This was independent of heat labile complement factors. Antibodies specific for P. levii were assessed for protease activity capable of cleaving bovine immunoglobulins (IgG, IgG1, IgG2, and IgM). Partially purified supernatant from broth cultures of P. levii were incubated with biotinylated immunoglobulins (Igs). Samples were taken from times 0 to 72 h and examined using SDS-PAGE followed by Western blot analysis. Streptavidin-alkaline phosphatase and NBT-BCIP were used to visualize the Igs for heavy and light chains as well as lower molecular weight fragments of these glycoproteins. Porphyromonas levii produced an immunoglobulin protease which readily cleaved bovine IgG into fragments, but did not act against IgM. Specifically, the enzyme may be a significant virulence factor as it may act to neutralize the antibodies demonstrated necessary for effective PMN-mediated phagocytosis. (+info)In vivo protection of Fusobacterium necrophorum from penicillin by Bacteroides fragilis. (2/297)
A mixed infection of Bacteroides fragilis and Fusobacterium necrophorum was resistant to treatment with penicillin even though a pure F. necrophorum infection could be successfully treated with penicillin. Since B. fragilis alone did not produce infection, these results indicate that B. fragilis can protect F. necrophorum from penicillin in vivo. The extent of protection afforded by a strain of B. fragilis was related to its level of resistance to penicillin. Only a few cells of B. fragilis were required in the initial bacterial injection. Moreover, protection was demonstrated when B. fragilis cells were injected as late as 24 h after the F. necrophorum cells. Protection of F. necrophorum from penicillin by B. fragilis was also demonstrated in vitro. (+info)Effect of virginiamycin on ruminal fermentation in cattle during adaptation to a high concentrate diet and during an induced acidosis. (3/297)
The objective of Exp. 1 was to compare the effects of virginiamycin (VM; 0, 175, or 250 mg x animal(-1) x d(-1)) and monensin/tylosin (MT; 250/ 90 mg x animal(-1) x d(-1)) on ruminal fermentation products and microbial populations in cattle during adaptation to an all-concentrate diet. Four ruminally cannulated, Holstein steers were used in a 4x4 Williams square design with 21-d periods. Steers were stepped up to an all-concentrate diet fed at 2.5% of BW once daily. Ruminal pH, protozoal counts, and NH3-N and VFA concentrations generally were unaffected by VM or MT. Mean counts of Lactobacillus and Streptococcus bovis were lower (P<.05) for VM-treated compared with control or MT-treated steers. Both VM and MT prevented the increase in Fusobacterium necrophorum counts associated with increasing intake of the high-concentrate diet observed in the control. The objective of Exp. 2 was to compare the effects of VM and MT on ruminal pH, L(+) lactate and VFA concentrations, and F. necrophorum numbers during carbohydrate overload. Six ruminally cannulated Holstein steers were assigned randomly to either the control, VM (175 mg/d), or MT (250 + 90 mg/d) treatments. Acidosis was induced with intraruminal administration of a slurry of ground corn and corn starch. The VM and MT premixes were added directly to the slurry before administration. Carbohydrate challenge induced acute ruminal acidosis (pH was 4.36 and L (+) lactate was 19.4 mM) in controls by 36 h. Compared with the controls, steers receiving VM or MT had higher (P<.05) ruminal pH, and the VM group had a lower (P<.05) L (+) lactate concentration. Fusobacterium necrophorum numbers initially increased in VM- and MT-administered steers. In the control steers, F. necrophorum was undetectable by 36 h. Virginiamycin seemed to control the growth of ruminal lactic acid-producing bacteria and, therefore, has the potential to moderate ruminal fermentation in situations that could lead to rapid production of lactic acid. (+info)Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut. (4/297)
The human intestinal tract harbors a complex microbial ecosystem which plays a key role in nutrition and health. Although this microbiota has been studied in great detail by culture techniques, microscopic counts on human feces suggest that 60 to 80% of the observable bacteria cannot be cultivated. Using comparative analysis of cloned 16S rRNA gene (rDNA) sequences, we have investigated the bacterial diversity (both cultivated and noncultivated bacteria) within an adult-male fecal sample. The 284 clones obtained from 10-cycle PCR were classified into 82 molecular species (at least 98% similarity). Three phylogenetic groups contained 95% of the clones: the Bacteroides group, the Clostridium coccoides group, and the Clostridium leptum subgroup. The remaining clones were distributed among a variety of phylogenetic clusters. Only 24% of the molecular species recovered corresponded to described organisms (those whose sequences were available in public databases), and all of these were established members of the dominant human fecal flora (e.g., Bacteroides thetaiotaomicron, Fusobacterium prausnitzii, and Eubacterium rectale). However, the majority of generated rDNA sequences (76%) did not correspond to known organisms and clearly derived from hitherto unknown species within this human gut microflora. (+info)Phylogenetic analysis of Fusobacterium alocis and Fusobacterium sulci based on 16S rRNA gene sequences: proposal of Filifactor alocis (Cato, Moore and Moore) comb. nov. and Eubacterium sulci (Cato, Moore and Moore) comb. nov. (5/297)
Genes encoding the 16S rRNA of Fusobacterium alocis ATCC 35896T and Fusobacterium sulci ATCC 35585T were sequenced. These sequences did not have any affinity with the 16S rRNA gene sequences of members of the genus Fusobacterium. Fusobacterium alocis ATCC 35896T and Fusobacterium sulci ATCC 35585T belonged to Clostridium cluster XI; the species most closely related to these strains were Filifactor villosus NCTC 11220T and Eubacterium infirmum W1471, respectively. Two new combinations are proposed: Filifactor alocis (Cato, Moore and Moore) comb. nov. (type strain ATCC 35896T) and Eubacterium sulci (Cato, Moore and Moore) comb. nov. (type strain ATCC 35585T). (+info)Occurrence of the new tetracycline resistance gene tet(W) in bacteria from the human gut. (6/297)
Members of our group recently identified a new tetracycline resistance gene, tet(W), in three genera of rumen obligate anaerobes. Here, we show that tet(W) is also present in bacteria isolated from human feces. The tet(W) genes found in human Fusobacterium prausnitzii and Bifidobacterium longum isolates were more than 99.9% identical to those from a rumen isolate of Butyrivibrio fibrisolvens. (+info)Serological study of trichloroacetic acid extracts of Bacteroides fragilis. (7/297)
Immunodiffusion techniques were used on trichloroacetic acid extracts from 10 strains of Bacteroides fragilis in detecting precipitating antibodies against this species in immune rabbit sera. Species and even strain specificities were observed in these precipitin reactions. Multiple antigens were detected in the extracts from some strains, whereas only one precipitin band per extract developed during agar-gel diffusion tests of others. The antigen extracts were found to be both heat stable and resistant to hydrolysis by alpha-chymotrypsin. Four serological patterns were demonstrated in homologous and heterologous reactions with the B. fragilis. antigen-antibody systems used. The results showed that some strains were serologically distinct from others, indicating that the strains tested are of more than one serotype. (+info)Detection of tetQ and ermF antibiotic resistance genes in Prevotella and Porphyromonas isolates from clinical specimens and resident microbiota of humans. (8/297)
Gram-negative anaerobes belonging to the genera Fusobacterium, Prevotella and Porphyromonas were investigated for the presence of tetQ and ermF, which have been shown to be spread by conjugal elements. One hundred isolates from either sites of infection or various body sites in healthy subjects were studied. PCR was used to detect tetQ, and DNA-DNA hybridization studies on EcoRI chromosomal digests were undertaken to detect the presence of tetQ and ermF. Antibiotic sensitivity assays were performed on selected isolates to detect tetracycline, erythromycin and penicillin resistance. Twenty Fusobacterium isolates lacked tetQ, and were tetracycline sensitive. Twenty per cent of Prevotella spp. isolates both from clinical specimens and from healthy subjects were found to possess tetQ. Of 20 Porphyromonas isolates tested, one (Porphyromonas levii) from a case of bacterial vaginosis was shown to possess tetQ in the chromosome. The presence of tetQ was always associated with tetracycline resistance. Four isolates of Prevotella melaninogenica and one isolate of Prevotella were ermF-positive, although expression of erythromycin resistance was not consistently associated with detection of this gene. Antibiotic resistance phenotypes of Prevotella isolates were shown to be related to specific chromosomal restriction patterns by hybridization studies: tetracycline resistance and tetracycline/erythromycin resistance are conferred by Bacteroides tetracycline-resistant ERL elements, whereas the tetracycline/penicillin resistance phenotype could be due to spread of elements identified in Prevotella only. Tetracycline/erythromycin-resistant and tetracycline/erythromycin/penicillin-resistant P. melaninogenica isolates were found in this study. It appeared that the presence of tetQ and ermF in Bacteroides and Prevotella contributed to the persistence of antibiotic resistance isolates within the host and to potential spread to other organisms through conjugal elements. (+info)
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PorphyromonasSpeciesSubspBacteroidesInfectionsInfectionBacteremiaAnaerobicBacteriaPolymorphumBacteriumGenusMicrobiotaMicrobiologyLiver abscessesPeriodontal diseasesStreptococcusPathogenTumorigenesisAntimicrobialAnaerobeDiagnosed with colorectal cancerStrainsAntibioticTumorsCarcinogenesisMetronidazolePrevalenceClinicalEndocarditis2016OrganismVirulence1991Tumour growthAnalysesMicrobiomePharyngitisLipopolysaccharidesMice
Porphyromonas11
- Although infections with periopathogenic bacteria such as Porphyromonas gingivalis ( P. gingivalis ) and Fusobacterium nucleatum ( F. nucleatum ) are essential for inducing periodontitis, the nature and magnitude of the disease is determined by the host's immune response. (pubmedcentralcanada.ca)
- Using an in vitro tissue culture model, a selected group of gram-negative anaerobic bacteria frequently associated with periodontal diseases, including Bacteroides forsythus, Campylobacter curvus, Eikenella corrodens, Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia, were examined for their ability to adhere to and invade primary cultures of human gingival epithelial cells (HGEC). (eurekamag.com)
- Since Toll-like receptor 2 (TLR2), TLR4, and TLR9 activation have been involved in HIV-1 recrudescence, we sought to determine the role of these TLRs in HIV-1 reactivation induced by the periodontal pathogens Fusobacterium nucleatum and Porphyromonas gingivalis using BF24 monocytes/macrophages stably transfected with the HIV-1 promoter driving chloramphenicol acetyltransferase (CAT) expression and THP89GFP cells, a model of HIV-1 latency. (asm.org)
- The present research aims to examine a periodontal disease model in which specific pathogen-free Wistar rats are orally exposed to Porphyromonas gingivalis associated with Fusobacterium nucleatum . (bvsalud.org)
- The experimental animals were repeatedly infected with Porphyromonas gingivalis and Fusobacterium nucleatum for one week. (bvsalud.org)
- Our study showed that four weeks following infection with Porphyromonas gingivalis and Fusobacterium nucleatum bone loss in Wistar rats could be identified. (bvsalud.org)
- Este estudo teve o objetivo de induzir doença periodontal pela inoculação oral da Porphyromonas gingivalis associada à Fusobacterium nucleatum em ratos da linhagem Wistar. (bvsalud.org)
- Os animais do grupo experimental foram infectados oralmente por Porphyromonas gingivalis associada à Fusobacterium nucleatum durante uma semana. (bvsalud.org)
- O presente estudo demonstrou que 4 semanas de infecção pelas bactérias Porphyromonas gingivalis e Fusobacterium nucleatum promoveu perda óssea em ratos da linhagem Wistar. (bvsalud.org)
- Abstract The aim of this study was to compare the biological activity of lipopolysaccharides (LPS) purified from Fusobacterium nucleatum and Porphyromonas gingivalis strains , both isolated from primary endodontic infection (PEI) in the levels of IL-1 β and TNF-α released by macrophage cells . (bvsalud.org)
- Resumo O objetivo deste estudo foi comparar a atividade biológica de lipopolissacarídeos (LPS) purificados a partir de linhagens de Fusobacterium nucleatum e Porphyromonas gingivalis , ambas isoladas de infecções endodônticas primárias (IEP) nos níveis de IL-1 β e TNF-α produzidos por macrófagos . (bvsalud.org)
Species26
- The diverse Fusobacterium genus contains species implicated in multiple clinical pathologies, including periodontal disease, preterm birth, and colorectal cancer. (asm.org)
- Actively invading Fusobacterium species can enter host cells independently, whereas passively invading species need additional factors, such as compromise of mucosal integrity or coinfection with other microbes. (asm.org)
- In the largest and most comprehensive comparison of sequenced Fusobacterium species to date, we have generated a testable model for the molecular pathogenesis of Fusobacterium infection and illuminate new therapeutic or diagnostic strategies. (asm.org)
- IMPORTANCE Fusobacterium species have recently been implicated in a broad spectrum of human pathologies, including Crohn's disease, ulcerative colitis, preterm birth, and colorectal cancer. (asm.org)
- Largely due to the genetic intractability of member species, the mechanisms by which Fusobacterium causes these pathologies are not well understood, although adherence to and active invasion of host cells appear important. (asm.org)
- We examined whole-genome sequence data from a diverse set of Fusobacterium species to identify genetic determinants of active forms of host cell invasion. (asm.org)
- Our analyses revealed that actively invading Fusobacterium species have larger genomes than passively invading species and possess a specific complement of genes-including a class of genes of unknown function that we predict evolved to enable host cell adherence and invasion. (asm.org)
- The bacterial genus Fusobacterium is comprised of at least 13 species that are primarily anaerobic, nonmotile, non-spore-forming, Gram-negative rods and members of the normal human microbiota ( 1 ). (asm.org)
- 16S rRNA gene-based sequencing projects have resolved the Fusobacterium genus into groups of species that can be loosely characterized by their interactions with the human host and potential to cause disease ( 1 - 3 ). (asm.org)
- Some Fusobacterium species are capable of "actively" invading host cells without the aid of other factors, whereas other species require compromise of mucosal integrity or coinfection with a virus for host cell invasion ( 4 ). (asm.org)
- Fusobacterium is one of the bacterial species recently identified in the gastrointestinal tract, with implications for the treatment of colorectal cancer . (colonhealthmagazine.com)
- It was only recently discovered that bacterial species such as Fusobacterium are found in the colorectal tumors. (colonhealthmagazine.com)
- Further research is necessary to determine the underlying connection between Fusobacterium as bacterial species and colorectal cancer cells. (colonhealthmagazine.com)
- For all of these reasons, scientists believe that, in the future, the treatment for colorectal cancer might target the Fusobacterium bacterial species living in close connection with the tumor. (colonhealthmagazine.com)
- In performing this study, scientists were able to confirm that Fusobacterium is an invasive bacterial species, supporting the inflammation in the gastrointestinal tract. (colonhealthmagazine.com)
- The anaerobic, Gram-negative bacterial species Fusobacterium nucleatum is a common resident of the human mouth and gut and varies in its pathogenic potential. (asm.org)
- The non-spore-forming, anaerobic, Gram-negative bacterial species Fusobacterium nucleatum is both a normal inhabitant of the human mouth and gut and a recognized opportunistic pathogen implicated in inflammatory diseases of both the mouth, such as periodontitis, and the gut, such as appendicitis and IBD ( 36 , 40 , 43 ). (asm.org)
- However, the Fusobacterium species and subspecies involved and their oncogenic mechanisms remain to be determined. (aacrjournals.org)
- Fusobacterium nucleatum is a gram-negative anaerobic species residing in the oral cavity and implicated in several inflammatory processes in the human body. (biomedcentral.com)
- Fusobacterium species (spp. (biomedcentral.com)
- Fusobacterium species is a topic covered in the Johns Hopkins ABX Guide . (hopkinsguides.com)
- Johns Hopkins Guide , www.hopkinsguides.com/hopkins/view/Johns_Hopkins_ABX_Guide/540675/all/Fusobacterium_species. (hopkinsguides.com)
- Multiple Fusobacterium species are oral pathogens that infect a broad range of human organ and tissue niches ( 1 , 2 ). (asm.org)
- Previous research from several laboratories identified the bacterial species, called Fusobacterium nucleatum , as one of the most prevalent in colorectal tumors. (cancer.gov)
- Several other species of bacteria often found living with Fusobacterium were also detected in both primary and metastatic tumors and in similar proportions at both sites, suggesting a stable microbial community centered around Fusobacterium , wrote the authors. (cancer.gov)
- The research team then created a new mouse model of colorectal cancer using tissue taken from patients whose tumors harbored Fusobacterium and other associated bacterial species. (cancer.gov)
Subsp8
- Fusobacterium nucleatum subsp. (nih.gov)
- Genomic DNA from Fusobacterium nucleatum subsp. (atcc.org)
- AE009951 Fusobacterium nucleatum subsp. (atcc.org)
- Terpenoid backbone biosynthesis - Fusobacterium nucleatum subsp. (genome.jp)
- Fusobacterium n. subsp. (vetstream.com)
- TIG_FUSNN Trigger factor OS=Fusobacterium nucleatum subsp. (uniprot.org)
- annotation:(type:'catalytic activity' rhea:21736) AND reviewed:yes AND organism:'Fusobacterium nucleatum subsp. (uniprot.org)
- Detection of Fusobacterium necrophorum subsp. (microbiologyresearch.org)
Bacteroides3
- Fusobacterium is a genus of anaerobic, Gram-negative, non-sporeforming bacteria, similar to Bacteroides. (wikipedia.org)
- Lemierre's syndrome is also known as postangina septicemia, which is commonly caused by Fusobacterium necrophorum also known as Necrobacillus and also by other microorganisms like Staphylococcus , Streptococcus , Peptostreptococcus , and Bacteroides . (hindawi.com)
- Leptotrichiaceae, Fusobacterium , Mycoplasma, Trueperella and Bacteroides had greater relative abundances in post-mortem lung samples collected from fatal cases of BRD in dairy calves, compared with clinically healthy calves without lung lesions. (biomedcentral.com)
Infections8
- Infections caused by Fusobacterium necrophorum within the fields of obstetrics and gynecology have been infrequently reported. (hindawi.com)
- Filifactor alocis, originally known as Fusobacterium alocis, was first isolated in1985 from the human gingival crevice, and has since been discovered in patients suffering from chronic periodontitis, generalized aggressive, periodontitis and endodontic infections. (uniprot.org)
- In a 3-year prospective study, all cases of disseminated Fusobacterium necrophorum infections found in Denmark from 1998 to 2001 were analysed, with the aim of describing the epidemiology and clinical features of the variants of Lemierre's syndrome and disseminated non-head-and-neck-associated F. necrophorum infections. (springer.com)
- Although uncommon, Fusobacterium infections have a wide clinical spectrum, ranging from local pharyngeal infections to septic shock. (jccm.ro)
- Our aim was to characterize and analyze the clinical features and outcomes in patients with Fusobacterium infections, and determine which variables were able to predict a poor outcome. (jccm.ro)
- Although we found no deaths attributable to Fusobacterium, 15 patients (57%) were found to have severe infections due to this pathogen, and 7 patients (26.9%) were admitted to the Intensive Care Unit (ICU). (jccm.ro)
- Fusobacterium infections are uncommon. (jccm.ro)
- Created by the university's Sanjeev Narayanan, Amit Kumar, T.G. Nagaraja and M.M. Chengappa, the new technology can be used to treat infections caused by Fusobacterium without the use of antibiotics. (outbreaknewstoday.com)
Infection8
- We describe a 19-year-old woman who underwent a cesarean delivery complicated by sepsis and purulent uterine necrosis secondary to Fusobacterium necrophorum infection. (hindawi.com)
- Riordan T (2007) Human infection with Fusobacterium necrophorum (Necrobacillosis), with a focus on Lemierre's syndrome. (springer.com)
- Fusobacterium necrophorum usually causes infection in animals and rarely affects humans. (hindawi.com)
- 2016), that described how we intended to replicate an experiment from the paper ' Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma' (Castellarin et al. (elifesciences.org)
- The researchers developed a solution that could provide effective, antibiotic-free prevention of Fusobacterium necrophorum infection. (outbreaknewstoday.com)
- Fusobacterium nucleatum is a prominent member of the oral microbiota and is a common cause of human infection. (duhnnae.com)
- The team discovered a specific protein that plays a pivotal role in mediating Fusobacterium attachment to the host cells that allow pathologic infection of the host. (outbreaknewstoday.com)
- Our invention helps induce an immunologic response in the host, which would prevent attachment and establishment of Fusobacterium in cattle, thus providing protection against the infection. (outbreaknewstoday.com)
Bacteremia3
- We report 4 cases of Fusobacterium nucleatum bacteremia associated with coronavirus disease (COVID-19). (cdc.gov)
- In addition, the relative role of co-morbidities on the acquisition of Fusobacterium bacteremia has not yet been teased out. (biomedcentral.com)
- A 25-year-old male without prior co-morbidities was admitted to hospital with Fusobacterium necrophorum bacteremia, where he was found to have liver and splenic abscesses. (nebraska.edu)
Anaerobic6
- Fusobacterium nucleatum is a Gram-negative anaerobic bacterium prevalent in the human oral cavity. (cornell.edu)
- Fusobacterium nucleatum is a gram-negative anaerobic rod member of the oral and digestive microbiota ( 1 ). (cdc.gov)
- During the last decade, the anaerobic, pleomorphic Gram-negative rod Fusobacterium necrophorum has been suggested to play an important pathogenic role in acute and recurrent tonsillitis as well as in persistent sore throat syndrome [ 12 - 15 ]. (biomedcentral.com)
- Anaerobic cultures obtained from blood and intramural thrombus were positive for Fusobacterium nucleatum. (scirp.org)
- Fusobacterium nucleatum is a gram-negative anaerobic bacterium best known as a component of the oral plaque and a key pathogen in gingivitis and periodontitis [ 1 ]. (biomedcentral.com)
- Fusobacterium nucleatum is a Gram-negative anaerobic organism that plays a central role in the development of periodontal diseases. (microbiologyresearch.org)
Bacteria7
- Among gram-negative bacteria implicated in periodontal diseases, Fusobacterium nucleatum, is one of the most interesting. (nih.gov)
- However, the recent research confirmed that the Fusobacterium bacteria travel at the same time with the cancerous cells, through the bloodstream. (colonhealthmagazine.com)
- Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. (biomedsearch.com)
- Identification of a Fusobacterium nucleatum PK1594 galactose-binding adhesin which mediates coaggregation with periopathogenic bacteria and hemagglutination. (asm.org)
- Recently, certain gut bacteria, including some in the Fusobacterium genus, have been implicated in playing a role in human colorectal cancer development. (aacrjournals.org)
- This suggests that the bacteria may be travelling with cancer cells through the bloodstream to the sites of metastasis, instead of new Fusobacterium cells joining the metastatic cells at their distant sites, he said. (cancer.gov)
- If an approach to specifically killing Fusobacterium could destroy only the cancer-associated community of bacteria, "then maybe that would impact the cancer without having a lot of impact on the rest of the [body's] microbiome," he concluded. (cancer.gov)
Polymorphum2
- Fusobacterium polymorphum is a bacterium that has been isolated from the gingival crevice in humans, and has been implicated in the immunopathology of periodontal disease. (wikipedia.org)
- Genome Sequence of Fusobacterium nucleatum Subspecies Polymorphum - a Genetically Tractable Fusobacterium - Descarga este documento en PDF. (duhnnae.com)
Bacterium4
- The same oral commensal bacterium and gum disease pathogen called Fusobacterium nucleatum was found to be predominantly associated with primary human colorectal cancer cells and even in distant metastatic lesions, a study published in 2017 on the journal Science , reports. (uct.ac.za)
- Clinically, infected aortoiliac aneurysm complicated by Fusobacterium is extremely rare relative to the prevalence of the pathogenic bacterium. (scirp.org)
- Fusobacterium nucleatum has recently been connected with colorectal cancer (CRC) ( 3 , 4 ), with studies showing that this bacterium induces a proinflammatory microenvironment and chemoresistance against drugs used to treat CRC ( 5 - 7 ). (asm.org)
- Nagaraja and his associates discovered that the Fusobacterium bacterium is able to survive in the liver because it produces leukotoxins. (outbreaknewstoday.com)
Genus2
- F. prausnitzii, a gut commensal associated with healthy patients, was moved out of Fusobacterium into its own genus, Faecalibacterium, in 2002. (wikipedia.org)
- The genus Fusobacterium was highly enriched in tumors, while the Bacteroidetes and Firmicutes phyla were depleted.We show that in the \(Apc^{Min/+}\) mouse model of intestinal tumorigenesis, Fusobacterium nucleatum increases tumor multiplicity, selectively recruits tumor-infiltrating myeloid cells, and is associated with a pro-inflammatory expression signature that is shared with human fusobacteria-positive colorectal carcinomas. (harvard.edu)
Microbiota4
- Leung A, Tsoi H, Yu J (2015) Fusobacterium and Escherichia: models of colorectal cancer driven by microbiota and the utility of microbiota in colorectal cancer screening. (springer.com)
- However, the disturbance of intestinal microbiota and the role of Fusobacterium nucleatum during the colorectal adenoma-carcinoma sequence have not yet been evaluated. (oncotarget.com)
- Fusobacterium nucleatum é um anaeróbio estrito e considerado membro da microbiota indígena da cavidade bucal humana. (unesp.br)
- We found a significant difference in diversity between elderly individuals living in a nursing home (EN) and healthy control (HC) subjects, as well as in the microbiota composition at the phyla level. (nature.com)
Microbiology1
- We thank all of the Danish departments of clinical microbiology, who sent us the Fusobacterium necrophorum isolates, the clinical departments, who provided us with records from all of the patients, E. Olsen for help with the SPSS software and N. Nørskov-Lauritsen for critical advice with the manuscript. (springer.com)
Liver abscesses4
- We report a case of infected iliac artery aneurysm concomitant with liver abscesses caused by Fusobacterium nucleatum. (scirp.org)
- A Rare Case of Fusobacterium Necrophorum Liver Abscesses. (hepaton.com)
- Fusobacterium necrophorum causing liver abscesses is a rare condition and only a few cases have been reported. (hepaton.com)
- Fusobacterium is well known for causing liver abscesses in cattle and sheep, and has been identified as a human pathogen that can cause some periodontal - or gum - diseases, topical skin ulcers, Lemierre's syndrome and other conditions. (outbreaknewstoday.com)
Periodontal diseases1
- Strains of Fusobacterium cause several human diseases, including periodontal diseases, Lemierre's syndrome, and topical skin ulcers. (wikipedia.org)
Streptococcus1
- The levels of opportunistic pathogens, such as Fusobacterium , Streptococcus and Enterococcus spp. (oncotarget.com)
Pathogen3
- Although older sources state that Fusobacterium is part of the normal flora of the human oropharynx, the current consensus is that Fusobacterium should always be treated as a pathogen. (wikipedia.org)
- In summary, FusoPortal ( http://fusoportal.org ) is the first database of MinION-sequenced and completely assembled Fusobacterium genomes, and this central Fusobacterium genomic and bioinformatic resource will aid the scientific community in developing a deeper understanding of how this human pathogen contributes to an array of diseases, including periodontitis and colorectal cancer. (asm.org)
- We believe that the availability of this resource will result in the discovery of proteins and molecular mechanisms used by an oral pathogen, with the potential to further our understanding of how Fusobacterium nucleatum contributes to a repertoire of diseases, including periodontitis, preterm birth, and colorectal cancer. (asm.org)
Tumorigenesis3
- Fusobacterium nucleatum potentiates intestinal tumorigenesis and modulates the tumor-immune microenvironment. (nih.gov)
- Additionally, in the Apc(Min/+) mouse model of intestinal tumorigenesis, Fusobacterium nucleatum increases tumor multiplicity and selectively recruits tumor-infiltrating myeloid cells, which can promote tumor progression. (nih.gov)
- Bashir A, Miskeen AY, Bhat A, Fazili KM, Ganai BA (2015) Fusobacterium nucleatum: an emerging bug in colorectal tumorigenesis. (springer.com)
Antimicrobial1
- Although it is not clear yet if good oral hygiene would probably add advantage to preventive measures to colorectal cancer outcome, these scientists recommended the use of antibiotic Metronidazole, Fusobacterium -specific antimicrobial agents or phage therapy concurrently in colon cancer treatment. (uct.ac.za)
Anaerobe3
- Fusobacterium nucleatum is a gram-negative anaerobe ubiquitous to the oral cavity. (biomedsearch.com)
- Fusobacterium nucleatum is an oral anaerobe associated with periodontal disease, adverse pregnancy outcomes and colorectal carcinoma. (duhnnae.com)
- Fusobacterium nucleatum is a strict anaerobe and is indigenous of the human oral cavity. (unesp.br)
Diagnosed with colorectal cancer1
- The potential antibiotics that might be used to eliminate the Fusobacterium in patients diagnosed with colorectal cancer would have to present a high level of particularity. (colonhealthmagazine.com)
Strains1
- IMPORTANCE In this report, we describe a hybrid MinION whole-genome sequencing pipeline and the genomic characteristics of the first eight Fusobacterium strains deposited in the FusoPortal database. (asm.org)
Antibiotic2
- To test how antibiotic treatment might impact tumor growth, the researchers treated these mice with erythromicin, which does not kill Fusobacterium, or metronidazole , which does. (cancer.gov)
- Potential antibiotic approaches to killing Fusobacterium in patients with colorectal cancer would need to be very specific, explained Dr. Meyerson. (cancer.gov)
Tumors6
- According to recent research , Fusobacterium is found at the site of colon and rectal tumors. (colonhealthmagazine.com)
- The research confirmed the presence of Fusobacterium in both primary tumors and liver metastases. (colonhealthmagazine.com)
- To see whether Fusobacterium is also found at sites in the body where colorectal cancer has spread, the research team performed whole-genome sequencing on frozen tissue samples from primary tumors and liver metastases from 11 patients. (cancer.gov)
- Of these, seven had Fusobacterium DNA in both the primary and metastatic tumors. (cancer.gov)
- Erythromycin had no effect on the growth of Fusobacterium -positive tumors, but metronidazole reduced both the number of Fusobacterium in tumors and the rate of tumor cell proliferation and tumor growth. (cancer.gov)
- The tumors are [likely] benefiting from Fusobacterium -the Fusobacterium may be providing essential nutrients or growth signals to the tumor," explained Phillip Daschner, a program director with NCI's Division of Cancer Biology who was not involved with the study. (cancer.gov)
Carcinogenesis2
- The underlying mechanism of Fusobacterium nucleatum (Fn) in the carcinogenesis of colorectal cancer (CRC) is poorly understood. (oncotarget.com)
- Fusobacterium nucleatum (F. nucleatum), which has been associated with colorectal carcinogenesis, can impair anti-tumour immunity, and actively invade colon epithelial cells. (elsevier.com)
Metronidazole1
- Fusobacterium endocarditis treated with metronidazole. (bmj.com)
Prevalence1
- Prevalence of Fusobacterium necrophorum in persistent sore throat samples. (dmu.ac.uk)
Clinical4
- in clinical colorectal cancer specimens by targeted sequencing of Fusobacterium 16S ribosomal RNA gene. (aacrjournals.org)
- Recent studies show that a high amount of tissue-associated Fusobacterium nucleatum (Fn) has been connected to an advanced disease stage and poor clinical outcome in colorectal cancer (CRC) [ 1 , 2 ]. (oncotarget.com)
- Fusobacterium necrophorum may cause a number of clinical syndromes, collectively known as necrobacillosis. (springer.com)
- This case emphasizes the need for a high index of clinical suspicion to make the diagnosis of Fusobacterium necrophorum meningitis. (springer.com)
Endocarditis1
- We report a case of splenic abscess due to Fusobacterium nucleatum in a patient who had a history of intravenous drug abuse and no evidence of endocarditis. (annals.org)
20161
- Nosho K, Sukawa Y, Adachi Y, Ito M, Mitsuhashi K, Kurihara H et al (2016) Association of Fusobacterium nucleatum with immunity and molecular alterations in colorectal cancer. (springer.com)
Organism3
- In 2011, researchers discovered that Fusobacterium flourishes in colon cancer cells, and is often also associated with ulcerative colitis, although researchers have not determined if the organism actually causes these diseases or if it simply flourishes in the environment these diseases create. (wikipedia.org)
- Fusobacterium necrophorum is infrequently implicated as a pathogenic organism. (hindawi.com)
- The causative organism was identified to be Fusobacterium nucleatum by Karius testing. (infectoforum.net)
Virulence1
19911
- Burden P (1991) Fusobacterium necrophorum and Lemierre's syndrome. (springer.com)
Tumour growth2
- Fusobacterium nucleatum may promote colorectal tumour growth and inhibit T cell-mediated immune responses against colorectal tumours. (bmj.com)
- Despite other studies suggesting the possible pro-tumorigenic role of Fusobacterium which may include modulation of host immune response to cancer cells and further enhancement of tumour cell invasion in colon cancer pathogenesis, this new study was scientifically able to show the correlation between decrease in Fusobacterium load and the decreased in rate of tumour growth and improved overall patient survival. (uct.ac.za)
Analyses2
- Metagenomic analyses indicate that symbiotic Fusobacterium spp. (nih.gov)
- Additional analyses confirmed that Fusobacterium nucleatum ssp. (aacrjournals.org)
Microbiome1
- In order to evaluate microbiome-based biomarkers for non-invasive detection of CRC, the levels of Fusobacterium nucleatum and selected Escherichia coli toxin genes in stool and mucosa from a small cohort of Norwegian patients were investigated. (springer.com)
Pharyngitis2
- A study found that in adolescents and young adults, Fusobacterium necrophorum pharyngitis was more common than group A beta-hemolytic streptococcal (GAS) pharyngitis. (medscape.com)
- European data suggest that in patients aged 15 to 30 years, Fusobacterium necrophorum causes at least 10% of cases of pharyngitis. (medscape.com)
Lipopolysaccharides2
- Chemical structure of the lipid A component of lipopolysaccharides from Fusobacterium nucleatum. (asm.org)
- The lipid A component of lipopolysaccharides from Fusobacterium nucleatum Fev 1 consists of beta-1',6-linked D-glucosamine disaccharides, which carry two phosphate groups: one in glycosidic and one in ester linkage. (asm.org)
