Formaldehyde is a colorless, flammable, strong-smelling chemical compound, primarily used as a preservative in medical laboratories and fungicide, which is also produced naturally in the human body and released during decomposition.

Sensory perception is related to the rate of change of volatile concentration in-nose during eating of model gels. (1/90)

The relationship between perceived aroma and the volatile concentration measured in-nose was investigated during eating of a model food. Sensory ranking and time-intensity analysis (TI) were used to measure perceived aroma, while in-nose volatile concentration was monitored by atmospheric pressure ionization mass spectrometry, which produced time release data. A gelatine-sucrose gel with a range of gelatine concentrations (2-8% w/w) and flavoured with furfuryl acetate was used as the model food. Sensory scaling showed decreased flavour intensities and TI showed a decrease in the flavour perceived over time, as the gelatine concentration increased. Studies in model systems and in people demonstrated that the different rates of release observed for different gelatine concentrations were not due to binding of volatile to protein in the gel, nor to mucous membranes, but were due to different rates of gel breakdown in-mouth. There were no significant differences in the maximum in-nose volatile concentrations for the different gelatine concentrations, so the amount of volatile present did not correlate well with the sensory analysis. However, the rates of volatile release were different for the different gels and showed a good correlation with sensory data.  (+info)

Mechanisms of DNA cleavage by copper complexes of 3-clip-phen and of its conjugate with a distamycin analogue. (2/90)

Mechanisms of DNA oxidation by copper complexes of 3-Clip-Phen and its conjugate with a distamycin analogue, in the presence of a reductant and air, were studied. Characterisation of the production of 5-methylenefuranone (5-MF) and furfural, associated with the release of nucleobases, indicated that these copper complexes oxidised the C1' and C5' positions of 2-deoxyribose, respectively, which are accessible from the DNA minor groove. Oxidation at C1' was the major degradation route. Digestion of DNA oxidation products by P1 nuclease and bacterial alkaline phosphatase allowed characterisation of glycolic acid residues, indicating that these copper complexes also induced C4' oxidation. However, this pathway was not associated with base propenal release. The ability of the copper complex of the 3-Clip-Phen conjugate with the distamycin analogue to produce sequence-selective DNA cleavage allowed confirmation of these mechanisms of DNA oxidation by PAGE. Comparison of DNA cleavage activity showed that conjugation of 3-Clip-Phen with a DNA minor groove binder, like the distamycin analogue, decreased both its ability to perform C1' oxidation as well as the initial rate of the reaction, but this conjugate is still active after 5 h at 37 degrees C, making it an efficient DNA cleaver.  (+info)

Determination of carboxylic acids, carbohydrates, glycerol, ethanol, and 5-HMF in beer by high-performance liquid chromatography and UV-refractive index double detection. (3/90)

A high-performance liquid chromatographic method is proposed for the simultaneous separation of main carboxylic acids, carbohydrates, ethanol, glycerol, and 5-HMF in beer by direct injection. A column packed with a sulfonated divinyl benzene-styrene copolymer and an isocratic elution with 0.0045N sulfuric acid and acetonitrile (6%, v/v) are employed. UV and refractive index detectors connected in series are also used to reduce the matrix interference of phenolic compounds. In conditions described, nine compounds are quantitated in a single chromatographic run without any pretreatment except for sample dilution and filtration before injection. Precision, accuracy, linearity of response, limit of detection, and limit of quantitation are also evaluated for each compound. Satisfactory results are obtained to justify the application of this method to all phases of beer production for process and quality control.  (+info)

Degradation in peritoneal dialysis fluids may be avoided by using low pH and high glucose concentration. (4/90)

OBJECTIVE: When glucose is present in a medical fluid, the heat applied during sterilization leads to degradation. The glucose degradation products (GDPs) give rise to bioincompatible reactions in peritoneal dialysis patients. The extent of the degradation depends on a number of factors, such as heating time, temperature, pH, glucose concentration, and catalyzing substances. In the present work, we investigated the influence of pH and concentration in order to determine how to decrease the amounts of GDPs produced. DESIGN: Glucose solutions (1%-60% glucose; pH 1-8) were heat sterilized at 121 degrees C. Ultraviolet (UV) absorption, aldehydes, pH, and inhibition of cell growth (ICG) were used as measures of degradation. RESULTS: Glucose degradation was minimum at an initial pH (prior to sterilization) of around 3.5 and at a high concentration of glucose. There was considerable development of acid degradation products during the sterilization process when the initial pH was high. Two different patterns of development of UV-absorbing degradation products were seen: one below pH 3.5, dominated by the formation of 5-hydroxy-methyl-2-furaldehyde (5-HMF); and one above, dominated by degradation products absorbing at 228 nm. 3-Deoxyglucosone (3-DG) concentration and the portion of 228 nm UV absorbance not caused by 5-HMF were found to relate to the in vitro bioincompatibility measured as ICG; there was no relation between 5-HMF or absorbance at 284 nm and bioincompatibility. CONCLUSION: In order to minimize the development of bioincompatible GDPs in peritoneal dialysis fluids during heat sterilization, pH should be kept around 3.2 and the concentration of glucose should be high. 5-HMF and 284 nm UV absorbance are not reliable as quality measures. 3-DG and the portion of UV absorbance at 228 nm caused by degradation products other than 5-HMF seem to be reliable indicators of bioincompatibility.  (+info)

Inhibition effects of furfural on alcohol dehydrogenase, aldehyde dehydrogenase and pyruvate dehydrogenase. (5/90)

The kinetics of furfural inhibition of the enzymes alcohol dehydrogenase (ADH; EC 1.1.1.1), aldehyde dehydrogenase (AlDH; EC 1.2.1.5) and the pyruvate dehydrogenase (PDH) complex were studied in vitro. At a concentration of less than 2 mM furfural was found to decrease the activity of both PDH and AlDH by more than 90%, whereas the ADH activity decreased by less than 20% at the same concentration. Furfural inhibition of ADH and AlDH activities could be described well by a competitive inhibition model, whereas the inhibition of PDH was best described as non-competitive. The estimated K(m) value of AlDH for furfural was found to be about 5 microM, which was lower than that for acetaldehyde (10 microM). For ADH, however, the estimated K(m) value for furfural (1.2 mM) was higher than that for acetaldehyde (0.4 mM). The inhibition of the three enzymes by 5-hydroxymethylfurfural (HMF) was also measured. The inhibition caused by HMF of ADH was very similar to that caused by furfural. However, HMF did not inhibit either AlDH or PDH as severely as furfural. The inhibition effects on the three enzymes could well explain previously reported in vivo effects caused by furfural and HMF on the overall metabolism of Saccharomyces cerevisiae, suggesting a critical role of these enzymes in the observed inhibition.  (+info)

Diastereoselective imino-aldol condensation of chiral 3-(p-Tolylsulfinyl)-2-furaldimine and ester enolates. (6/90)

(Ss)-3-(p-Tolylsufinyl)-2-furaldimine was synthesized, and condensation of the chiral furaldimine with lithium ester enolates has been examined. The product distribution of the reaction is dependent upon reaction conditions and on the kind of the substituent placed on the esters. Disubstituted ester enolate resulted in the exclusive formation of (4R)-beta-lactam, while unsubstituted, tert-butyl ester enolate preferentially gave (3R)-beta-amino ester. With the monosubstituted ester enolates, the condensation afforded (4R)-beta-lactams and/or (3R)-beta-amino esters as major products. This method has been applied to an efficient route to chiral furyl beta-lactams.  (+info)

Reactivity of 5-nitro-2-furaldehyde in alkaline and acidic solutions. (7/90)

5-Nitro-2-furaldehyde (NFA) forms in alkaline solutions an anion of nitronic acid of (5-nitro-furan-2-yl)-methanediol. Upon acidification (5-nitro-furan-2-yl)-methanediol (HNFA) appears with pKa=4.6. Then, in a novel irreversible redox ring-opening reaction, nitrile oxide of alpha-ketoglutaconic acid is formed which hydrolyses in acidic solutions. With increasing pH it dimerizes to furoxane or polymerizes to hydraxamates. Some of the products were separated and identified by IR and NMR spectroscopy, confirmed by elemental analysis.  (+info)

An improved HPLC analysis of the metabolite furoic acid in the urine of workers occupationally exposed to furfural. (8/90)

An improved high-performance liquid chromatographic (HPLC) method for the analysis of the metabolite furoic acid in the urine of workers occupationally exposed to furfural is described. The procedure involved an alkaline hydrolysis step followed by solvent extraction using ethyl acetate. HPLC analysis used an acidic acetonitrile/water mobile phase with a C18 column and ultraviolet detection. The overall relative recovery of furoic acid in urine was found to be 98.8% with a relative standard deviation of 9.7%. The limit of quantitation was determined to be 0.01 mmol/L.  (+info)

Formaldehyde is not a medication or a term commonly used in human medicine. It is a chemical compound with the formula CH2O, which is commonly used in industry for various purposes such as a preservative, disinfectant, and embalming agent. Formaldehyde is also found naturally in the environment and is produced in small amounts by certain animals, plants, and humans.

Exposure to formaldehyde can cause irritation of the eyes, nose, throat, and skin, and prolonged exposure has been linked to cancer, particularly nasopharyngeal cancer and leukemia. Therefore, it is important to limit exposure to this chemical and use appropriate protective equipment when handling it.

"5-(Hydroxymethyl)-2-furaldehyde". pubchem.ncbi.nlm.nih.gov. Retrieved 2018-06-25. Kläusli, Thomas (2014). "AVA Biochem: ...
4-benzenetriol from 5-hydroxymethyl-2-furaldehyde and d-fructose". Carbohydrate Research. 242: 131-139. doi:10.1016/0008-6215( ...
4-benzenetriol from 5-hydroxymethyl-2-furaldehyde and D-fructose". Carbohydrate Research. 242 (1): 131-139. doi:10.1016/0008- ...
The chemical composition of the areca husk consists of 18.75% furaldehyde which when distilled produces 5.5% furfural; it also ...
It has been claimed that 5-methoxymethyl-2-furaldehyde prevents the growth of fungi in leathers, paints, foods and fabrics. ... Podesta, Federico; Fajardo, Victor; Freyer, Alan J.; Shamma, Maurice (1988). "5-Methoxymethyl-2-furaldehyde: A Natural Furanoid ...
The most prominent furanic compounds include 2-furaldehyde and 5-methylfuraldehyde, which can contribute to the smoky flavor of ...
This species also produces an antifungal compound, 5-pentyl-2-furaldehyde, that inhibits the mycelial growth of Alternaria ...
... furaldehyde MeSH D03.383.312.490 - lasalocid MeSH D03.383.312.520 - maleic anhydrides MeSH D03.383.312.600 - monensin MeSH ...
The molecular formula C5H4O2 (molar mass: 96.085 g/mol) may refer to: Furfural (2-furaldehyde) 3-Furaldehyde Protoanemonin ...
2-furaldehyde oxime - cas 1121-47-7, synthesis, structure, density, melting point, boiling point ... Tags: melting point of 2-furaldehyde oxime - 1121-47-7 , boiling point of 2-furaldehyde oxime - 1121-47-7 , density of 2- ... furaldehyde oxime - 1121-47-7 , refractive index of 2-furaldehyde oxime - 1121-47-7 ...
Learn more about 3-Methyl-2-furaldehyde. We enable science by offering product choice, services, process excellence and our ...
"Furaldehyde" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical Subject ... This graph shows the total number of publications written about "Furaldehyde" by people in UAMS Profiles by year, and whether " ... Below are the most recent publications written about "Furaldehyde" by people in Profiles over the past ten years. ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice ...
"5-(Hydroxymethyl)-2-furaldehyde". pubchem.ncbi.nlm.nih.gov. Retrieved 2018-06-25. Kläusli, Thomas (2014). "AVA Biochem: ...
Furaldehyde, 2-. 98-01-1. Liquid. 198*/227. Furfural. 98-01-1. Liquid. 198*/227. ...
2-Furaldehyde;1/C5H4O2/c6-4-5-2-1-3-7-5/h1-4;2-Furil-metanale;Furfurale [Italian];RCRA waste no. U125;2-Furancarbonal;furan-2- ...
5-Ethyl-2-furaldehyde (C7H8O2). *2-n-Butylacrolein (C7H12O) ...
Sensomics analysis of taste compounds in balsamic vinegar and discovery of 5-acetoxymethyl-2-furaldehyde as a novel sweet taste ...
Analyses of amines and of hydrazine reaction products of 2- furaldehyde have been performed by gas chromatography. ...
For example, both nitric oxide and ammonia can be analysed, as well as hydrogen sulphide, pyridine, 2-furaldehyde, 2- ...
5-nitro-2-furaldehyde p-hydroxybenzoylhydrazone ...
We assessed the effects of steam processing and the differences in R. glutinosa material on 5-Hydroxymethyl-2-furaldehyde (5- ...
Opening of the furan ring in 5-azido-2-furaldehyde. 1980, Vol. 45, Issue 1, pp. 150-154 [Abstract] ... Synthesis and properties of styryl derivatives of 2-furaldehyde. 1981, Vol. 46, Issue 2, pp. 515-519 [Abstract] ...
Opening of the furan ring in 5-azido-2-furaldehyde. 1980, Vol. 45, Issue 1, pp. 150-154 [Abstract] ... Synthesis and properties of styryl derivatives of 2-furaldehyde. 1981, Vol. 46, Issue 2, pp. 515-519 [Abstract] ...
Synthesis Of 5-Nitro-2-Furaldehyde Diacetate Is Initial Phase Of Batchwise Procedure. 5-Nitro-2-Furaldehyde Diacetate Is ... Synthesis Of Furazolidone Is Based On Reaction Of 3-Amino-2-Oxazolidone With 5-Nitro-2-Furaldehyde Diacetate. Analytical Tests ...
furaldehyde metabolic process gliotoxin metabolic process + glutamate catabolic process to 4-hydroxybutyrate ...
RAM4651… Furaldehyde 2,2-dimethyl-hydrazone. Article number: RAM4651. CAS number: 14064-21-2. Molecular formula: C7H10N2O. ...
5-Hydroxymethyl-2-furaldehyde, 99% - 5 G. Link Lien. * Acide amidosulfurique très pur - 2.5 kg. Link Lien ...
The first to interest me was a rather neat asymmetric alkylation of furaldehyde to put in the first stereocentre. Four steps ...
Furaldehyde. Shandong Hanteng International Trade Co., Ltd. (affiliated to Shandong Water Source New Energy Technology Co., Ltd ...
Furaldehyde. Shandong Hanteng International Trade Co., Ltd. (affiliated to Shandong Water Source New Energy Technology Co., Ltd ...
CupriavidusCupriavidus necatorBurkholderiaceaeMimosa2,4-Dichlorophenoxyacetic AcidFuraldehydeChlorobenzoatesVolcanic Eruptions ... 2,4-Dichlorophenoxyacetic AcidFuraldehydeChlorobenzoatesIsethionic AcidChlorophenolsSelenic AcidAlkanesulfonates ...
2-Furancarboxaldehyde; 2-Furaldehyde; 2-Formylfuran; 2-Furanaldehyde; 2-Furancarbaldehyde; 2-Furancarbonal; 2-Furfural; 2- ... Furfuraldehyde; 2-Furylaldehyde; 2-Furylcarboxaldehyde; Artificial ant oil; Fural; Furaldehyde; Furan-2-carboxaldehyde; ...
2-Furaldehyde. by Cary, R , Dobson, Stuart , Gregg, N , World Health Organization , International Programme on Chemical Safety. ...
2-FURALDEHYDE / ENVIRONNEMENT / EVALUATION / EXPOSITION / IMPACT DE LA POLLUTION / PRODUIT CHIMIQUE / PROPRIETE CHIMIQUE / ... 2-Furaldehyde. Gen ve : World Health Organization (WHO) (OMS) (Organisation mondiale de la sant ), 2000. 27 p (Concise ...
The markers of carbohydrates are 3/2-furaldehyde, 5-methyl-2-furaldehyde, 4-hydroxy-5,6-dihydro-(2H)-pyran-2-one, ...
  • Pyromucic aldehyde;2-Furil-metanale [Italian];Bran oil;2-Furyl-methanal;Furyl-methanal;2-Furfural;Furfuraldehyde;Furol;Furfurol;Quakeral;2-Furanaldehyde;2-Furaldehyde;1/C5H4O2/c6-4-5-2-1-3-7-5/h1-4;2-Furil-metanale;Furfurale [Italian];RCRA waste no. (lookchem.com)
  • Among furan derivatives, 2-furaldehyde (furfural) and 5-hydroxymethylfurfural (HMF) constitute the main degradation compounds generated from pentoses and hexoses degradation, respectively. (atamanchemicals.com)
  • Analyses of amines and of hydrazine reaction products of 2- furaldehyde have been performed by gas chromatography. (cdc.gov)
  • Meanwhile, our company has complete testing method and powerful technical strength, with the annual output of 15,000 tons of furaldehyde, 30,000 tons of furfuryl alcohol, 10,000 tons of casting resin and 5,000 tons of sodium salts. (vivifysalonspa.com)
  • There are 2 production chains: furaldehyde- furfuryl alcohol-casting resin and furaldehyde- natrium aceticum- sodium salt. (vivifysalonspa.com)
  • Musau, R.M. and Munavu, R.M. (1990) 'The conversion of 2-furaldehyde into some potentially useful bifunctional derivatives', Biomass , 23(4), p. 275. (stanford.edu)
  • The synthesis of a number of 5-nitro- and 5-amino-2-furaldehyde derivatives is described in this review. (heterocycles.jp)
  • Honeydew present on the cotton underwent thermochemical degradation with concomitant production of the compound 5-hydroxymethyl-2-furaldehyde (HMF). (cotton.org)