Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.
Particles consisting of aggregates of molecules held loosely together by secondary bonds. The surface of micelles are usually comprised of amphiphatic compounds that are oriented in a way that minimizes the energy of interaction between the micelle and its environment. Liquids that contain large numbers of suspended micelles are referred to as EMULSIONS.
The thermodynamic interaction between a substance and WATER.
Anhydride polymers with a repeating structure of RC(=O)OC(=O)R. They readily hydrolyze in water making them useful for DELAYED-ACTION PREPARATIONS.
Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).
A copolymer of polyethylene and polypropylene ether glycol. It is a non-ionic polyol surface-active agent used medically as a fecal softener and in cattle for prevention of bloat.
Conditions characterized by abnormal lipid deposition due to disturbance in lipid metabolism, such as hereditary diseases involving lysosomal enzymes required for lipid breakdown. They are classified either by the enzyme defect or by the type of lipid involved.
Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A change from planar to elliptic polarization when an initially plane-polarized light wave traverses an optically active medium. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
Tree-like, highly branched, polymeric compounds. They grow three-dimensionally by the addition of shells of branched molecules to a central core. The overall globular shape and presence of cavities gives potential as drug carriers and CONTRAST AGENTS.
Characteristics or attributes of the outer boundaries of objects, including molecules.
Layers of lipid molecules which are two molecules thick. Bilayer systems are frequently studied as models of biological membranes.
Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.
Venoms produced by the wasp (Vespid) family of stinging insects, including hornets; the venoms contain enzymes, biogenic amines, histamine releasing factors, kinins, toxic polypeptides, etc., and are similar to bee venoms.
A component of NEOMYCIN that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Relating to the size of solids.
Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The level of protein structure in which regular hydrogen-bond interactions within contiguous stretches of polypeptide chain give rise to alpha helices, beta strands (which align to form beta sheets) or other types of coils. This is the first folding level of protein conformation.
Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
An enzyme that catalyzes the hydrolysis of ACETYLCHOLINE to CHOLINE and acetate. In the CNS, this enzyme plays a role in the function of peripheral neuromuscular junctions. EC 3.1.1.7.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Basic polypeptide from the venom of the honey bee (Apis mellifera). It contains 26 amino acids, has cytolytic properties, causes contracture of muscle, releases histamine, and disrupts surface tension, probably due to lysis of cell and mitochondrial membranes.
Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.
Nanometer-sized, hollow, spherically-shaped objects that can be utilized to encapsulate small amounts of pharmaceuticals, enzymes, or other catalysts (Glossary of Biotechnology and Nanobiotechnology, 4th ed).
Positively charged atoms, radicals or groups of atoms which travel to the cathode or negative pole during electrolysis.
Materials in intermediate state between solid and liquid.
A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.
Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.
A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)
The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
The homogeneous mixtures formed by the mixing of a solid, liquid, or gaseous substance (solute) with a liquid (the solvent), from which the dissolved substances can be recovered by physical processes. (From Grant & Hackh's Chemical Dictionary, 5th ed)
The characteristic three-dimensional shape of a molecule.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
The rate dynamics in chemical or physical systems.
The adhesion of gases, liquids, or dissolved solids onto a surface. It includes adsorptive phenomena of bacteria and viruses onto surfaces as well. ABSORPTION into the substance may follow but not necessarily.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
Lipids, predominantly phospholipids, cholesterol and small amounts of glycolipids found in membranes including cellular and intracellular membranes. These lipids may be arranged in bilayers in the membranes with integral proteins between the layers and peripheral proteins attached to the outside. Membrane lipids are required for active transport, several enzymatic activities and membrane formation.
Strongly cationic polymer that binds to certain proteins; used as a marker in immunology, to precipitate and purify enzymes and lipids. Synonyms: aziridine polymer; Epamine; Epomine; ethylenimine polymer; Montrek; PEI; Polymin(e).
Electron microscopy in which the ELECTRONS or their reaction products that pass down through the specimen are imaged below the plane of the specimen.
Materials fabricated by BIOMIMETICS techniques, i.e., based on natural processes found in biological systems.
Used in copolymerization reactions, in the Diels-Alder(diene)synthesis, in the preparation of resins, pharmaceuticals and agricultural chemicals. It is a powerful irritant and causes burns.
The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
Artificially produced membranes, such as semipermeable membranes used in artificial kidney dialysis (RENAL DIALYSIS), monomolecular and bimolecular membranes used as models to simulate biological CELL MEMBRANES. These membranes are also used in the process of GUIDED TISSUE REGENERATION.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.
The force acting on the surface of a liquid, tending to minimize the area of the surface. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to a choline moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and choline and 2 moles of fatty acids.
A sympathomimetic agent that was formerly used as an anorectic. It has properties similar to those of DEXTROAMPHETAMINE. It has been implicated in lipid storage disorders and pulmonary hypertension. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1223)
The prototypical tricyclic antidepressant. It has been used in major depression, dysthymia, bipolar depression, attention-deficit disorders, agoraphobia, and panic disorders. It has less sedative effect than some other members of this therapeutic group.
The physical phenomena describing the structure and properties of atoms and molecules, and their reaction and interaction processes.
Most abundant proteins in COBRA venom; basic polypeptides of 57 to 62 amino acids with four disulfide bonds and a molecular weight of less than 7000; causes skeletal and cardiac muscle contraction, interferes with neuromuscular and ganglionic transmission, depolarizes nerve, muscle and blood cell membranes, thus causing hemolysis.
Polymers of N-SUBSTITUTED GLYCINES containing chiral centers at the a-position of their side chains. These oligomers lack HYDROGEN BONDING donors, preventing formation of the usual intrachain hydrogen bonds but can form helices driven by the steric influence of chiral side chains.
The generic name for the group of aliphatic hydrocarbons Cn-H2n+2. They are denoted by the suffix -ane. (Grant & Hackh's Chemical Dictionary, 5th ed)
Purifying or cleansing agents, usually salts of long-chain aliphatic bases or acids, that exert cleansing (oil-dissolving) and antimicrobial effects through a surface action that depends on possessing both hydrophilic and hydrophobic properties.
A rigorously mathematical analysis of energy relationships (heat, work, temperature, and equilibrium). It describes systems whose states are determined by thermal parameters, such as temperature, in addition to mechanical and electromagnetic parameters. (From Hawley's Condensed Chemical Dictionary, 12th ed)
The study of CHEMICAL PHENOMENA and processes in terms of the underlying PHYSICAL PHENOMENA and processes.
The mixture of gases present in the earth's atmosphere consisting of oxygen, nitrogen, carbon dioxide, and small amounts of other gases.
An anticholesteremic agent that inhibits sterol biosynthesis in animals.
Measurement of the intensity and quality of fluorescence.
A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.
Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN=CR2.
The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
Synthetic or natural materials, other than DRUGS, that are used to replace or repair any body TISSUES or bodily function.
Nanometer sized fragments of semiconductor crystalline material which emit PHOTONS. The wavelength is based on the quantum confinement size of the dot. They can be embedded in MICROBEADS for high throughput ANALYTICAL CHEMISTRY TECHNIQUES.
Venoms obtained from Apis mellifera (honey bee) and related species. They contain various enzymes, polypeptide toxins, and other substances, some of which are allergenic or immunogenic or both. These venoms were formerly used in rheumatism to stimulate the pituitary-adrenal system.
Agents that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags.
A synthetic phospholipid used in liposomes and lipid bilayers for the study of biological membranes.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A group of compounds derived from ammonia by substituting organic radicals for the hydrogens. (From Grant & Hackh's Chemical Dictionary, 5th ed)
Low-molecular-weight compounds produced by microorganisms that aid in the transport and sequestration of ferric iron. (The Encyclopedia of Molecular Biology, 1994)
A nitrogen-free class of lipids present in animal and particularly plant tissues and composed of one mole of glycerol and 1 or 2 moles of phosphatidic acid. Members of this group differ from one another in the nature of the fatty acids released on hydrolysis.
A broad class of substances encompassing all those that do not include carbon and its derivatives as their principal elements. However, carbides, carbonates, cyanides, cyanates, and carbon disulfide are included in this class.
A type of scanning probe microscopy in which a probe systematically rides across the surface of a sample being scanned in a raster pattern. The vertical position is recorded as a spring attached to the probe rises and falls in response to peaks and valleys on the surface. These deflections produce a topographic map of the sample.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
Chemical reaction in which monomeric components are combined to form POLYMERS (e.g., POLYMETHYLMETHACRYLATE).
Inorganic compounds that contain cadmium as an integral part of the molecule.
Derivatives of phosphatidic acid in which the hydrophobic regions are composed of two fatty acids and a polar alcohol is joined to the C-3 position of glycerol through a phosphodiester bond. They are named according to their polar head groups, such as phosphatidylcholine and phosphatidylethanolamine.
A change of a substance from one form or state to another.
The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.
The diversion of RADIATION (thermal, electromagnetic, or nuclear) from its original path as a result of interactions or collisions with atoms, molecules, or larger particles in the atmosphere or other media. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)
A phosphorus-oxygen lyase found primarily in BACTERIA. The enzyme catalyzes the cleavage of a phosphoester linkage in 1-phosphatidyl-1D-myo-inositol to form 1D-myo-inositol 1,2-cyclic phosphate and diacylglycerol. The enzyme was formerly classified as a phosphoric diester hydrolase (EC 3.1.4.10) and is often referred to as a TYPE C PHOSPHOLIPASES. However it is now known that a cyclic phosphate is the final product of this enzyme and that water does not enter into the reaction.
A genus of gram-negative, rod-shaped bacteria in the family ALTEROMONADACEAE. The inability to utilize carbohydrates is a distinguishing feature from other genera in the family.
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
Peptides composed of between two and twelve amino acids.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Computer-based representation of physical systems and phenomena such as chemical processes.
The accumulation of an electric charge on a object
Negatively charged atoms, radicals or groups of atoms which travel to the anode or positive pole during electrolysis.
A class of antimicrobial peptides discovered in the skin of XENOPUS LAEVIS. They kill bacteria by permeabilizing cell membranes without exhibiting significant toxicity against mammalian cells.
Amino acid sequences found in transported proteins that selectively guide the distribution of the proteins to specific cellular compartments.
Small cationic peptides that are an important component, in most species, of early innate and induced defenses against invading microbes. In animals they are found on mucosal surfaces, within phagocytic granules, and on the surface of the body. They are also found in insects and plants. Among others, this group includes the DEFENSINS, protegrins, tachyplesins, and thionins. They displace DIVALENT CATIONS from phosphate groups of MEMBRANE LIPIDS leading to disruption of the membrane.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
One of the three major groups of endogenous opioid peptides. They are large peptides derived from the PRO-OPIOMELANOCORTIN precursor. The known members of this group are alpha-, beta-, and gamma-endorphin. The term endorphin is also sometimes used to refer to all opioid peptides, but the narrower sense is used here; OPIOID PEPTIDES is used for the broader group.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Usually high-molecular-weight, straight-chain primary alcohols, but can also range from as few as 4 carbons, derived from natural fats and oils, including lauryl, stearyl, oleyl, and linoleyl alcohols. They are used in pharmaceuticals, cosmetics, detergents, plastics, and lube oils and in textile manufacture. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 5th ed)
A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)
A type C phospholipase with specificity towards PHOSPHATIDYLINOSITOLS that contain INOSITOL 1,4,5-TRISPHOSPHATE. Many of the enzymes listed under this classification are involved in intracellular signaling.
Elements of limited time intervals, contributing to particular results or situations.
Substances that are toxic to blood in general, including the clotting mechanism; hematotoxins may refer to the hematopoietic system.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
Established cell cultures that have the potential to propagate indefinitely.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
A histamine H1 antagonist with low sedative action but frequent gastrointestinal irritation. It is used to treat ASTHMA; HAY FEVER; URTICARIA; and RHINITIS; and also in veterinary applications. Tripelennamine is administered by various routes, including topically.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.
An enzyme that activates aspartic acid with its specific transfer RNA. EC 6.1.1.12.
Polymerized forms of styrene used as a biocompatible material, especially in dentistry. They are thermoplastic and are used as insulators, for injection molding and casting, as sheets, plates, rods, rigid forms and beads.
A genus of gram-negative, rod-shaped or pleomorphic bacteria which are halotolerant. Members of this genus are capable of growth in sodium chloride concentrations of up to 20% or more. (From Bergey's Manual of Determinative Bacteriology, 9th ed)
Inorganic compounds that contain selenium as an integral part of the molecule.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
A complex of antibiotic substances produced by Streptomyces tenebrarius.
A class of enzymes that catalyze the hydrolysis of one of the two ester bonds in a phosphodiester compound. EC 3.1.4.
An interdisciplinary field in materials science, ENGINEERING, and BIOLOGY, studying the use of biological principles for synthesis or fabrication of BIOMIMETIC MATERIALS.
A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive; higher homologs have hemostatic and antibacterial properties.
Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.
Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)
The testing of materials and devices, especially those used for PROSTHESES AND IMPLANTS; SUTURES; TISSUE ADHESIVES; etc., for hardness, strength, durability, safety, efficacy, and biocompatibility.
A potent local anesthetic of the ester type used for surface and spinal anesthesia.
Polymers where the main polymer chain comprises recurring amide groups. These compounds are generally formed from combinations of diamines, diacids, and amino acids and yield fibers, sheeting, or extruded forms used in textiles, gels, filters, sutures, contact lenses, and other biomaterials.
The physical characteristics and processes of biological systems.
The sum of the weight of all the atoms in a molecule.
Single membrane vesicles, generally made of PHOSPHOLIPIDS.
Derivatives of phosphatidic acids in which the phosphoric acid is bound in ester linkage to an ethanolamine moiety. Complete hydrolysis yields 1 mole of glycerol, phosphoric acid and ethanolamine and 2 moles of fatty acids.
Two-phase systems in which one is uniformly dispersed in another as particles small enough so they cannot be filtered or will not settle out. The dispersing or continuous phase or medium envelops the particles of the discontinuous phase. All three states of matter can form colloids among each other.
Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.
Derivatives of PHOSPHATIDYLCHOLINES obtained by their partial hydrolysis which removes one of the fatty acid moieties.
Proteins found in any species of bacterium.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
The study of PHYSICAL PHENOMENA and PHYSICAL PROCESSES as applied to living things.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
The motion of phospholipid molecules within the lipid bilayer, dependent on the classes of phospholipids present, their fatty acid composition and degree of unsaturation of the acyl chains, the cholesterol concentration, and temperature.
The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.
Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye.
NMR spectroscopy on small- to medium-size biological macromolecules. This is often used for structural investigation of proteins and nucleic acids, and often involves more than one isotope.
A non-aqueous co-solvent that serves as tool to study protein folding. It is also used in various pharmaceutical, chemical and engineering applications.
Chemical analysis based on the phenomenon whereby light, passing through a medium with dispersed particles of a different refractive index from that of the medium, is attenuated in intensity by scattering. In turbidimetry, the intensity of light transmitted through the medium, the unscattered light, is measured. In nephelometry, the intensity of the scattered light is measured, usually, but not necessarily, at right angles to the incident light beam.
Processes involved in the formation of TERTIARY PROTEIN STRUCTURE.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A cyclic nonadecapeptide antibiotic that can act as an ionophore and is produced by strains of Trichoderma viride. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
Agents that induce various degrees of analgesia; depression of consciousness, circulation, and respiration; relaxation of skeletal muscle; reduction of reflex activity; and amnesia. There are two types of general anesthetics, inhalation and intravenous. With either type, the arterial concentration of drug required to induce anesthesia varies with the condition of the patient, the desired depth of anesthesia, and the concomitant use of other drugs. (From AMA Drug Evaluations Annual, 1994, p.173)
Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.
A fluorescent compound that emits light only in specific configurations in certain lipid media. It is used as a tool in the study of membrane lipids.
Thin structures that encapsulate subcellular structures or ORGANELLES in EUKARYOTIC CELLS. They include a variety of membranes associated with the CELL NUCLEUS; the MITOCHONDRIA; the GOLGI APPARATUS; the ENDOPLASMIC RETICULUM; LYSOSOMES; PLASTIDS; and VACUOLES.
A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.
A cell line derived from cultured tumor cells.
Five-membered heterocyclic ring structures containing an oxygen in the 1-position and a nitrogen in the 3-position, in distinction from ISOXAZOLES where they are at the 1,2 positions.
That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range.
Synthetic phospholipid used in liposomes and lipid bilayers to study biological membranes. It is also a major constituent of PULMONARY SURFACTANTS.
The movement of materials (including biochemical substances and drugs) through a biological system at the cellular level. The transport can be across cell membranes and epithelial layers. It also can occur within intracellular compartments and extracellular compartments.
Substances that prevent infectious agents or organisms from spreading or kill infectious agents in order to prevent the spread of infection.
A 31-amino acid peptide that is the C-terminal fragment of BETA-LIPOTROPIN. It acts on OPIOID RECEPTORS and is an analgesic. Its first four amino acids at the N-terminal are identical to the tetrapeptide sequence of METHIONINE ENKEPHALIN and LEUCINE ENKEPHALIN.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Colorless, odorless crystals that are used extensively in research laboratories for the preparation of polyacrylamide gels for electrophoresis and in organic synthesis, and polymerization. Some of its polymers are used in sewage and wastewater treatment, permanent press fabrics, and as soil conditioning agents.
A low-energy attractive force between hydrogen and another element. It plays a major role in determining the properties of water, proteins, and other compounds.
A computer simulation developed to study the motion of molecules over a period of time.
A group of peptide antibiotics from BACILLUS brevis. Gramicidin C or S is a cyclic, ten-amino acid polypeptide and gramicidins A, B, D are linear. Gramicidin is one of the two principal components of TYROTHRICIN.
A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016).
Semiautonomous, self-reproducing organelles that occur in the cytoplasm of all cells of most, but not all, eukaryotes. Each mitochondrion is surrounded by a double limiting membrane. The inner membrane is highly invaginated, and its projections are called cristae. Mitochondria are the sites of the reactions of oxidative phosphorylation, which result in the formation of ATP. They contain distinctive RIBOSOMES, transfer RNAs (RNA, TRANSFER); AMINO ACYL T RNA SYNTHETASES; and elongation and termination factors. Mitochondria depend upon genes within the nucleus of the cells in which they reside for many essential messenger RNAs (RNA, MESSENGER). Mitochondria are believed to have arisen from aerobic bacteria that established a symbiotic relationship with primitive protoeukaryotes. (King & Stansfield, A Dictionary of Genetics, 4th ed)
The chemical and physical integrity of a pharmaceutical product.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Substances that reduce the growth or reproduction of BACTERIA.
Gated, ion-selective glycoproteins that traverse membranes. The stimulus for ION CHANNEL GATING can be due to a variety of stimuli such as LIGANDS, a TRANSMEMBRANE POTENTIAL DIFFERENCE, mechanical deformation or through INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS.
Nonionic surfactant mixtures varying in the number of repeating ethoxy (oxy-1,2-ethanediyl) groups. They are used as detergents, emulsifiers, wetting agents, defoaming agents, etc. Octoxynol-9, the compound with 9 repeating ethoxy groups, is a spermatocide.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
Microscopy using an electron beam, instead of light, to visualize the sample, thereby allowing much greater magnification. The interactions of ELECTRONS with specimens are used to provide information about the fine structure of that specimen. In TRANSMISSION ELECTRON MICROSCOPY the reactions of the electrons that are transmitted through the specimen are imaged. In SCANNING ELECTRON MICROSCOPY an electron beam falls at a non-normal angle on the specimen and the image is derived from the reactions occurring above the plane of the specimen.
A family of spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one derivatives. These are used as dyes, as indicators for various metals, and as fluorescent labels in immunoassays.
Acrylic acids or acrylates which are substituted in the C-2 position with a methyl group.
Thin layers of tissue which cover parts of the body, separate adjacent cavities, or connect adjacent structures.
Proteins prepared by recombinant DNA technology.
Property of membranes and other structures to permit passage of light, heat, gases, liquids, metabolites, and mineral ions.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Transport proteins that carry specific substances in the blood or across cell membranes.
The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils.
The study of MAGNETIC PHENOMENA.
The sounds produced by humans by the passage of air through the LARYNX and over the VOCAL CORDS, and then modified by the resonance organs, the NASOPHARYNX, and the MOUTH.
The largest class of organic compounds, including STARCH; GLYCOGEN; CELLULOSE; POLYSACCHARIDES; and simple MONOSACCHARIDES. Carbohydrates are composed of carbon, hydrogen, and oxygen in a ratio of Cn(H2O)n.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
Proteins from BACTERIA and FUNGI that are soluble enough to be secreted to target ERYTHROCYTES and insert into the membrane to form beta-barrel pores. Biosynthesis may be regulated by HEMOLYSIN FACTORS.
A group of compounds containing the porphin structure, four pyrrole rings connected by methine bridges in a cyclic configuration to which a variety of side chains are attached. The nature of the side chain is indicated by a prefix, as uroporphyrin, hematoporphyrin, etc. The porphyrins, in combination with iron, form the heme component in biologically significant compounds such as hemoglobin and myoglobin.
The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
The semi-permeable outer structure of a red blood cell. It is known as a red cell 'ghost' after HEMOLYSIS.
Dosage forms of a drug that act over a period of time by controlled-release processes or technology.
They can be considered a sub-class of amphipols and are based on earlier fundamental explorations of amphiphilic secondary ... Kaiser, ET; Kézdy, FJ (20 January 1984). "Amphiphilic secondary structure: design of peptide hormones". Science. 223 (4633): ...
This makes them amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol, the polar ... They also play a fundamental role in the structure and function of cells. Consisting mainly of carbon, nitrogen, hydrogen, ... Marcel Dekker, Inc.: New York, 873 pages Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold ... Marcel Dekker, Inc.: New York, 873 pages Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold ...
In addition to fundamental contributions to the understanding of supramolecular systems, he has promoted their widespread use ... He reported the first example of this non-covalent polymerization by designing an amphiphilic porphyrin that spontaneously ... He has also made fundamental contributions in expanding the scope of supramolecular polymerization to include chain ... He also synthesized an amphiphilic version of hexabenzocoronene, a "molecular graphene", and succeeded in its supramolecular ...
Consequently, coping with damaged RNA genes while minimizing the costs of redundancy would likely have been a fundamental ... Such isolation is ordinarily accomplished by membranes, amphiphilic bilayers of a thickness of around 10-8 meters. Researchers ... Sakuma, Yuka; Imai, Masayuki (2015). "From Vesicles to Protocells: The Roles of Amphiphilic Molecules". Life. 5 (1): 651-75. ... amphiphilic molecules might be the first player in the evolution from molecular assembly to cellular life. A step from vesicle ...
They also play a fundamental role in the structure and function of cells.[11] Consisting mainly of carbon, nitrogen, hydrogen, ... This makes them amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol, the polar ... Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold vol.1., 1st Edition, ... Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold vol.1., 1st Edition, ...
"State of the art of smart polymers: from fundamentals to final applications." Polymer Science: research advances, practical ... "Stimuli-Responsive Amphiphilic Polyelectrolyte Heptablock Copolymer Physical Hydrogels: An Unusual pH-Response". Macromolecules ...
2013-12-09). Fundamentals of Pharmaceutical Nanoscience (2013 ed.). New York; Heidelberg: Springer. ISBN 9781461491637. "2012 ... Nanomerics develop molecular envelope technology nanoparticles from amphiphilic polymers that self-assemble. She won the Royal ... 2006 Polymers in Drug Delivery 2013 Fundamentals of Pharmaceutical Nanoscience 2007 UK Department for Business, Innovation and ...
Ethanol is an amphiphilic molecule meaning that it has chemical and physical properties associated with hydrophobic and ... Skoog, Douglas A; West, Donald M; Holler, James F.; Crouch, Stanly R. Fundamentals of Analytical Chemistry. 8th ed. Brooks/Cole ... All of these possible mechanisms can be contributed to ethanol's amphiphilic nature. Research overview: In this study there are ... Elsevier, 2003 and Skoog, Douglas A; West, Donald M; Holler, James F.; Crouch, Stanly R. Fundamentals of Analytical Chemistry. ...
The LB trough's general objective is to study the properties of monolayers of amphiphilic molecules. An amphiphilic molecule is ... Langmuir, I. (1917). THE CONSTITUTION AND FUNDAMENTAL PROPERTIES OF SOLIDS AND LIQUIDS. II. LIQUIDS. 1. Journal of the American ... The amphiphilic molecules dissolved in solvent are slowly dropped onto the liquid surface using a microsyringe, with care being ... In addition to amphiphilic materials, Langmuir-Blodgett Troughs are commonly used nowadays to create nanoparticle coatings with ...
"Light-induced amphiphilic surfaces". Nature 388, 431-432 (1997). "Self-cleaning glass", Engadget, June 4, 2004. Neat Glass ... investigations into the fundamental mechanisms of self-cleaning and characterizations of new coatings are regularly published ...
Scientists sometimes define lipids as hydrophobic or amphiphilic small molecules; the amphiphilic nature of some lipids allows ... The fatty acid structure is one of the most fundamental categories of biological lipids and is commonly used as a building- ... When dissolving a lipophilic or amphiphilic substance in a polar environment, the polar molecules (i.e., water in an aqueous ...
The fundamental roles that peptides and proteins play in today's biology makes it almost indisputable that peptides were key ... Within the hypothesis of a lipid bilayer membrane composed of a mixture of various distinct amphiphilic compounds there is the ... In fact, not only RNA and DNA, but many fundamental molecules of life (those common to all three domains of life) are also ... Michaelian, K; Simeonov, A (2015). "Fundamental molecules of life are pigments which arose and co-evolved as a response to the ...
Given the highly fundamental nature of molecular interactions, there are a plethora of potential application areas, limited ... amphiphilic peptide macromolecular assemblies induce a robust immune response) Peptide-containing biopharmaceuticals (e.g. ... which is widely regarded as giving birth to some of the fundamental ideas of the field of nanotechnology. In spite of the early ...
Biological molecules are amphiphilic or amphipathic, i.e. are simultaneously hydrophobic and hydrophilic. The phospholipid ... Fundamentals of Biochemistry: Life at the Molecular Level (4 ed.). Wiley. ISBN 978-1118129180. Dougherty, R. M.; Galli, C.; ...
Stein was the first to propose a model of the cell membrane as a fluid, amphiphilic structure. He presented this idea at the ... Fundamental to these studies was the mathematical modeling on transport of antimalarial drugs, collaborations with Ginsburg at ...
Voet, Donald (2012). Fundamentals of Biochemistry: Life at the Molecular Level (4 ed.). Wiley. ISBN 978-1118129180. .. ... Biological molecules are amphiphilic or amphipathic, i.e. are simultaneously hydrophobic and hydrophilic.[6] The phospholipid ...
Using equipment supplied by Brookhaven Instruments Corporation in New York State, provided the key to solving fundamental ... "Self-Assembling Amphiphilic Siderophores from Marine Bacteria," SCIENCE 2000, 287, 1245-1247. 9. Zhibin Guan, P. M. Cotts, E. F ...
As a result of its hydrocarbon tail, and its anionic "head group", it has amphiphilic properties that allow it to form micelles ... Ninfa, Alexander; Ballou, David (1998). Fundamental Laboratory Approaches for Biochemistry and Biotechnology. Hoboken, New ... Its hydrocarbon tail combined with a polar "headgroup" give the compound amphiphilic properties and so make it useful as a ... Fundamental Laboratory Approaches for Biochemistry and Biotechnology. United States: Wiley, John and Sons, Incorporated. p. 165 ...
This amphiphilic molecule has several polar groups (hydrophilic, water-loving) on the right side and a long nonpolar chain ( ... Because the amount of charge separated in such dipoles is usually smaller than a fundamental charge, they are called partial ... that have one end with polar groups attached and another end with nonpolar groups are described as amphiphiles or amphiphilic ...
... which are amphiphilic (partly hydrophobic and partly hydrophilic). Hence, the layer is called a phospholipid bilayer, or ... that cells are the fundamental unit of structure and function in all living organisms, and that all cells come from pre- ...
Many amphiphilic molecules show lyotropic liquid-crystalline phase sequences depending on the volume balances between the ... The fundamental insight here is that, whilst parallel arrangements of anisotropic objects lead to a decrease in orientational ... A compound that has two immiscible hydrophilic and hydrophobic parts within the same molecule is called an amphiphilic molecule ... At slightly higher (but still low) concentration, amphiphilic molecules will spontaneously assemble into micelles or vesicles. ...
In 1941, Derjaguin and Landau introduced a theory for the stability of colloidal dispersions that invoked a fundamental ... "Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway". Nature Communications ...
Butler, John M. (2009). Fundamentals of Forensic DNA Typing. Academic Press. ISBN 978-0-08-096176-7.. ... This makes them amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol, the polar ...
There are four fundamental steps in the fusion process. First, the involved membranes must aggregate, approaching each other to ... Biological bilayers are usually composed of amphiphilic phospholipids that have a hydrophilic phosphate head and a hydrophobic ...
Amphiphilic molecules[edit]. Large molecules that have one end with polar groups attached and another end with nonpolar groups ... Because the amount of charge separated in such dipoles is usually smaller than a fundamental charge, they are called partial ... This amphiphilic molecule has several polar groups (hydrophilic, water-loving) on the right side and a long nonpolar chain ( ... are described as amphiphiles or amphiphilic molecules. They are good surfactants and can aid in the formation of stable ...
... versatile arrays of amphiphilic helices working in crowded environments?". J. Cell Sci. 129 (21): 3963-3970. doi:10.1242/jcs. ... indicating that it is part of a fundamental regulatory mechanism conserved among different organisms and cell types. It is most ...
The LB trough's general objective is to study the properties of monolayers of amphiphilic molecules. An amphiphilic molecule is ... Langmuir, I. (1917). THE CONSTITUTION AND FUNDAMENTAL PROPERTIES OF SOLIDS AND LIQUIDS. II. LIQUIDS. 1. Journal of the American ... The amphiphilic molecules dissolved in solvent are slowly dropped onto the liquid surface using a microsyringe, with care being ... In addition to amphiphilic materials, Langmuir-Blodgett Troughs are commonly used nowadays to create nanoparticle coatings with ...
... which are amphiphilic (partly hydrophobic and partly hydrophilic). Hence, the layer is called a phospholipid bilayer, or ... that cells are the fundamental unit of structure and function in all living organisms, and that all cells come from pre- ...
Recent experiments and simulations are starting to answer some fundamental questions about how life came to be. ... amphiphilic Janus dendrimers (26) (Fig. 2). "Single-single" amphiphilic Janus dendrimer refers to a compound constructed from a ... Single-single amphiphilic Janus dendrimers 9a, 10a, 11a, 12a, and 13a (Fig. 2) also self-assemble into onion-like ... Amphiphilic Janus dendrimers take advantage of multivalency both in their hydrophobic and hydrophilic parts (23, 29⇓⇓-32). ...
Amphiphilic Polymers : in collaboration with IBM and IBN. Block copolymer amphiphiles are larger-scale analogues to surfactants ... Fundamentals of Macromolecular Self Assembly: particles, gels, and polyelectrolyte complex coacervates Share. Facebook LinkedIn ... Of particular interest are two types of self-assembling materials, oppositely charged ion-containing polymers and amphiphilic ... www.nist.gov/programs-projects/fundamentals-macromolecular-self-assembly-particles-gels-and-polyelectrolyte ...
Cram, D. J. Fundamentals o] Carbanion Chemistry. (1965).. *Szwarc, M. ACS Symposium Series. 166, American chemistry society. 1- ... In aqueous media, amphiphilic block copolymers such as mPEG-b-(PheGE)15 assemble to form micelles that consist of a hydrophobic ... In aqueous media, amphiphilic block copolymers assemble to form nano-sized block copolymer micelles (BCMs) that consist of a ... Lv, S., et al. Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer ...
Cram, D. J. Fundamentals o] Carbanion Chemistry. (1965).. *Szwarc, M. ACS Symposium Series. 166, American chemistry society. 1- ... Lv, S., et al. Doxorubicin-loaded amphiphilic polypeptide-based nanoparticles as an efficient drug delivery system for cancer ... Le Dévédec, F., Houdaihed, L., Allen, C. Anionic Polymerization of an Amphiphilic Copolymer for Preparation of Block Copolymer ...
Walters K. Fundamentals of Percutaenous Penetration. In: Brain K. R., Walters K, editors. Perspectives in Percutaneous ... Amphiphilic star-like macromolecules as novel carriers for topical delivery of nonsteroidal anti-inflammatory drugs. Jelena ... Alexandridis P. Amphiphilic copolymers and their application. Curr Opinions Colloid Interface Sci. 1996;1:490-501. ... Poly(ethylene glycol) (PEG) and Pluronic P-85 were used as polymer controls to compare the role of PEG and amphiphilic behavior ...
For faster download urban and regional economics marxist perspectives fundamentals of pure and, this Iframe is regenerating the ... By depending this download urban and regional economics marxist perspectives fundamentals of pure and applied economics series ... This download urban and regional economics marxist perspectives fundamentals of pure and applied had not flooded on 10 October ... Carcinogenesis, Amphiphilic), 2157-2169. The author publication, Ndrg-1: a sudden security-as-a-service in the risk against ...
b Department of Molecular and Mesoscale Modelling, Institute of Chemical Process Fundamentals of CAS, v. v. i., Rozvojová 135/1 ... Adsorption of amphiphilic graft copolymers in solvents selective for the grafts on a lyophobic surface: a coarse-grained ... Adsorption of amphiphilic graft copolymers in solvents selective for the grafts on a lyophobic surface: a coarse-grained ...
5.6.1 Self-Assembly of Amphiphilic Compounds 78. 5.6.2 Bilayer Lipid Membranes 79 ...
Intracellular Protein Delivery Using Self-Assembled Amphiphilic Polysaccharide Nanogels. Shimoda, Asako (et al.) ... Fundamental Biomedical Technologies. Series Volume. 7. Copyright. 2014. Publisher. Springer Netherlands. Copyright Holder. ...
This thesis work focuses on elucidating the fundamental aspects of the colloidal stability of highly concentrated CNF ... Molecular engineering of cellulose-PCL bio-nanocomposite interface by reactive amphiphilic copolymer nanoparticles. Kaldéus, ... reactive amphiphilic macromolecules with targeted side-chain functionalities were used to compatibilise the CNF surface by ...
"Preparation of multi-responsive amphiphilic particles by one-step soapless emulsion polymerization, Iranian Polymer Journal" on ... Meanwhile, the obtained multi-responsive polymers relying on simple and effective copolymerization can be used in fundamental ... Preparation of multi-responsive amphiphilic particles by one-step soapless emulsion polymerization. Wang, Bin; Zhai, Wenzhong; ... Multi-stimuli-responsive amphiphilic assemblies through simple postpolymerization modifications. Liu, X; Hu, D; Jiang, Z; ...
... and current research news encompassing the fundamental and applied research in all disciplines of science, engineering and ... "Inversed" Surface Micelle Array Fabrication of an Amphiphilic Block Copolymer on Water Surface ...
They can be considered a sub-class of amphipols and are based on earlier fundamental explorations of amphiphilic secondary ... Kaiser, ET; Kézdy, FJ (20 January 1984). "Amphiphilic secondary structure: design of peptide hormones". Science. 223 (4633): ...
The presented method constitutes a useful tool for fundamental studies of peptideâ€"membrane interactions and can also be ... 1. PEG-stabilized lipid disks as carriers for amphiphilic antimicrobial peptides. Open this publication in new window or tab ,, ... 3. EGF-targeting lipodisks for specific delivery of cationic amphiphilic peptides to tumour cells. Open this publication in new ... Open this publication in new window or tab ,,Characterizing and controlling the loading and release of cationic amphiphilic ...
It may looks up to 1-5 fundamentals before you received it. You can See a position conference and help your owners. satisfying ... is the s book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic ... You are book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic ... The book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic is ...
A fist fundamental step in this biomimetic process is to understand and to extract the underlying structure-function ... Amphiphilic molecules contain a hydrophilic headgroup and a hydrophobic tail. The prevailing molecular asymmetry leads to a ... A fist fundamental step in this biomimetic process is to understand and to extract the underlying structure-function ... Amphiphilic molecules contain a hydrophilic headgroup and a hydrophobic tail. The prevailing molecular asymmetry leads to a ...
Brooks NJ, Cates ME, Clegg PS, Lips A, Poon WCK, Seddon JMet al., 2016, Soft Interfacial Materials: from Fundamentals to ... Amphiphilic lipids aggregate in aqueous solution into a variety of structural arrangements. Among the plethora of ordered ... Lipids are fundamental components of biological organisms and have important applications in the pharmaceutical, food, and ... This article is part of the themed issue Soft interfacial materials: from fundamentals to formulation.The science of soft ...
This makes them amphiphilic molecules (having both hydrophobic and hydrophilic portions). In the case of cholesterol, the polar ... They also play a fundamental role in the structure and function of cells. Consisting mainly of carbon, nitrogen, hydrogen, ... Marcel Dekker, Inc.: New York, 873 pages Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold ... Marcel Dekker, Inc.: New York, 873 pages Physical Chemistry Of Food Processes: Fundamental Aspects.1992.van Nostrand-Reinhold ...
Phenolic antioxidants, as amphiphilic compounds, would collocate in this interface and usually are more effective in oil-in- ... Beyond this study, a "deep dive" and more fundamental understanding of this relation would help to reach an optimal, more ideal ... amphiphilic molecules, and the most common ones are small-molecule lipid-based emulsifiers, phospholipids, proteins and ... These amphiphilic components would likely associate in colloidal structures, generally reverse micelles and lamellar structure ...
In particular, we have studied fundamental aspects related to enhanced oil recovery, i.e. interfacial tension, micelle ... In this thesis, the interfacial Statistical Associating Fluid Theory that relies on fundamental measure theory, mean field ... "Thermodynamic Modeling and Molecular Simulation of Amphiphilic Systems." (2017) Diss., Rice University. https://hdl.handle.net/ ...
In: Fundamentals of Food Process Engineering, 2nd ed., pp. 315-397. Van Nostrand Reinhold, New York, USA.. Tsvetktov, T. and ... Stabilization of β-galactosidase by amphiphilic additives during freeze-drying, Int. J. Pharm. 90: 187-194.. Jaspers, D. A., ... In: Fundamentals and Applications of Freeze-drying to Biological Materials, Drugs and Food Stuffs. Internat. Institute of ... In: Fundamentals and Application of Freeze-dried to Biological Materials, Drugs and Foodstuffs. pp. 227-238. International ...
Self-assembly of amphiphilic molecules in aqueous media is of fundamental interest for applications in biotechnology and ... Design of amphiphilic diblock copolymer: Schematic representation of amphiphilic block copolymer which can respond to three ... Thus the proposed amphiphilic block copolymer has the potential to be used as a redox, acid, and temperature responsive system ... Our amphiphilic BCP was shown to self-assemble into micellar structure in aqueous solution and is capable of encapsulating ...
... fundamental polymer physics, and colloid chemistry to construct materials with new functionalities. ... Self-assembling processes of amphiphilic aqueous polymers, as well as their response to temperature, light, magnetic field, pH ... Our research combines modern synthetic polymer chemistry, fundamental polymer physics, and colloid chemistry. We master modern ...
Noy, D., Discher, B. M. Rubtsov, I. V., Hochstrasser, R. A. and Dutton, P. L., "Design of amphiphilic protein maquettes: ... Moser, C. C., Osyczka, A. and Dutton, P. L., "Short-circuit proofing Mitchells Q cycle" in Photosynthesis: Fundamental Aspects ... Kuroda, K. & DeGrado, W. F., "Amphiphilic polymethacrylate derivatives as antimicrobial agents: J Am Chem Soc 127, 4128-9 (2005 ... Soft Matters, 2013 Daeyeon Lee, et al "Amphiphilic Janus Particles at Fluid Interfaces" ...
present a fundamental study of zinc bis(1,4-didecylbenzo)-bis(2,3-pyrido)porphyrazine for application in photodynamic therapy ... focus on in vitro photodynamic activity of novel amphiphilic zinc(II) phthalocyanines bearing oxyethylene-rich substituents. E ...
Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule ... Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule ... these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein ... these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein ...
Fundamentals in Cell Biology. This course will teach the fundamentals in cell biology including cell structure and function. ... The course will offer an overview on self-assembly of amphiphilic molecules (surfactants) as well of nanoparticles. The topic ... Our research combines fundamental and application-oriented aspects in a multidisciplinary setting. Our scientists are currently ... This course will teach the fundamental concepts of biophysics and discuss modern techniques to study cells and biological ...
The key to both magainin and the arylamide polymers is that they are amphiphilic - one side attracts water while the other ... The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new ... "Unlike conventional antibiotics, for example, the arylamide s ability to attack a fundamental feature of all types of bacteria ...
Phospholipids are the fundamental building blocks of cellular membranes and are the major part of surfactant , the film that ... Phospholipids are the fundamental building blocks of cellular membranes and are the major part of surfactant , the film that ... This combination of polar and nonpolar segments is termed amphiphilic, and the word describes the tendency of these molecules ... Voet, Donald; Voet, Judith G.; and Pratt, Charlotte (1999). Fundamentals of Biochemistry. New York: Wiley. ...
These fundamental results will be augmented by a discussion of an application to thermoset epoxies, where the dispersion of ... Abstract: Block copolymers belong to a broad class of amphiphilic compounds that includes lipids, soaps, and nonionic ... In magnetic systems, fundamental noise can exist in the form of random spin fluctuations. For example, statistical fluctuations ... Certain fundamental noise sources contain valuable information about the system itself - a notable example being the inherent ...
  • In aqueous media, amphiphilic block copolymers assemble to form nano-sized block copolymer micelles (BCMs) that consist of a hydrophobic core surrounded by a hydrophilic shell or corona. (jove.com)
  • In this work, we have prepared all-conjugated block copolymers with both hole- and electron-conducting polymer blocks to improve performance and address fundamental questions regarding the structure and optoelectronic properties of OPV blends. (anl.gov)
  • Amphiphilic Block Copolymers for Nanoscale Drug Delivery. (indigo.ca)
  • Thus design and generation of discrete multicompartment with hierarchical nanostructures attempted to introduce hydrocarbon and fluorocarbon hydrophobic segments into linear dendritic amphiphilic A-graft-B-block-A-graft-C copolymers [9] . (pharmatutor.org)
  • Because regular amphiphilic molecules are too small for even this form of microscopy to see, the researchers used much larger molecules that work in the same way (block copolymers). (phys.org)
  • Using this solution processing approach, amphiphilic block copolymers (BCPs) with crystallizable blocks, related amphiphiles, and polymers with charged end groups will be used to predictably construct monodisperse samples of tailored, functional soft matter-based 2D nanostructures with controlled shape, size, and spatially-defined chemistries. (europa.eu)
  • A process to make amphiphilic graft copolymers via grafting either poly(ethylene oxide) or polylactide side chains onto an EVA platform using oxo-anion ring-opening polymerization chemistry is also described. (patentsencyclopedia.com)
  • Doğan, A. Differentiation of human stem cells is promoted by amphiphilic pluronic block copolymers [Text] / A. Doğan, M.E. Yalvaç, F. Şahin, A.V. Kabanov, A. Palotás, A.A. Rizvanov // International Journal of Nanomedicine. (kpfu.ru)
  • Here, we use molecular dynamics computer simulations and a simple, safe, and inexpensive popular hands-on activity, to communicate to participants why and how lipid molecules play a fundamental role in all living organisms and in our bodies. (imperial.ac.uk)
  • Self-assembly of amphiphilic molecules in aqueous media is of fundamental interest for applications in biotechnology and medicine, since most drug molecules are hydrophobic and therefore can be useful in drug delivery. (pubmedcentralcanada.ca)
  • In this report, we disclose the findings on the micellar properties of this amphiphilic block copolymer (BCP), study the responsiveness of the assembly to the stimuli, and the release kinetics of the encapsulated guest molecules in response to a stimulus by itself or to combinations of stimuli. (pubmedcentralcanada.ca)
  • This combination of polar and nonpolar segments is termed amphiphilic, and the word describes the tendency of these molecules to assemble at interfaces between polar and nonpolar phases. (encyclopedia.com)
  • Thus lipid molecules are amphiphilic, having both hydrophobic and hydrophilic portions. (newworldencyclopedia.org)
  • As a model system, we used amphiphilic polymer molecules carrying both water-repellent and water-compatible blocks, which spontaneously self-organize into so-called "micelles" when dispersed in water. (uio.no)
  • The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. (indigo.ca)
  • Artist impression of amphiphilic self-assembly from dissolved molecules (right, foreground), the formation of a nano-droplet (middle), into a liposome (left, far back). (phys.org)
  • Biological membranes, and man-made variants, consist of amphiphilic molecules, of which soap is an example. (phys.org)
  • A micelle is an extremely small spherical structure (about 100 nanometers) of amphiphilic molecules-all with the tails inwards and the heads outwards. (phys.org)
  • However, researchers at Eindhoven University of Technology discovered a different beginning: the formation of nano-droplets in water with a higher concentration of amphiphilic molecules. (phys.org)
  • At the interface of that drop, the amphiphilic molecules, as it were, take each others' hands: first they form spheres, which then change into cylinders or plates, and then a closed membrane is created that encloses the nano-droplet. (phys.org)
  • For monolayer-stabilised nanoparticles, established methods include ligand exchange to replace the ligand shell in its entirety, encapsulation with amphiphilic (macro)molecules, noncovalent interactions with surface-bound biomolecules, or a relatively limited number of covalent bond forming reactions. (rsc.org)
  • Amphiphilic molecules have a hydrophilic head and a hydrophobic chain. (cea.fr)
  • The vesicles are widely studied for many fundamental issues (mechanism of self-assembly, physical properties of the membrane, etc ...) which understanding may open new perspectives (controlled release of active molecules, chemical nanoreactors, energy conversion, etc. (cea.fr)
  • Another original and promising result of the absence of pores is the possibility of "self-encapsulation": upon association of the two amphiphilic molecules, their respective counter-ions (H + and Cl - ) are released into the solution, and a fraction is trapped into the aggregates [3]. (cea.fr)
  • The mechanisms of stabilization and "self-encapsulation" are very general and have already been extended to functionalized fatty acids or other amphiphilic molecules. (cea.fr)
  • For example, by using amphiphilic molecules - flotation reagents that are soluble in both polar solvents (e.g., fats) and nonpolar solvents (e.g., water). (hzdr.de)
  • Of particular interest are two types of self-assembling materials, oppositely charged ion-containing polymers and amphiphilic polymers. (nist.gov)
  • Meanwhile, the obtained multi-responsive polymers relying on simple and effective copolymerization can be used in fundamental research and industrial production. (deepdyve.com)
  • Self-assembling processes of amphiphilic aqueous polymers, as well as their response to temperature, light, magnetic field, pH, and ionic strength are the essential topics. (helsinki.fi)
  • The key to both magainin and the arylamide polymers is that they are amphiphilic - one side attracts water while the other repels it. (innovations-report.com)
  • Molecular Recognition and Polymers covers the fundamental aspects and applications of molecular recognition-in the creation of novel polymeric materials for use in drug delivery, sensors, tissue engineering, molecular imprinting, and other areas. (wiley.com)
  • The purpose of this networking activity is to gather people active in SONS projects related to polymer research and to set a frame for presenting results obtained within these projects, share general ideas on self-organization of amphiphilic polymers, review the state of the art in this discipline and promote the cooperation of various scientists taking part in these activities. (cas.cz)
  • The aim of the proposed workshop is a comprehensive interdisciplinary review of the current status of the subject and discussion of the most challenging problems and links between fundamental research and the nano-technological applications involving ion-containing polymers. (cas.cz)
  • Characterization - novel procedures for characterization of nanostructure in amphiphilic polymers in bulk and in dilute and concentrated solutions. (cas.cz)
  • In addition to fundamental studies, the proposed work also aims to make important impact in the cutting-edge fields of liquid crystals, interface stabilization, catalysis, supramolecular polymers, and hierarchical materials. (europa.eu)
  • The course gives students a fundamental introduction to concepts used to understand composition and properties of polymers and macromolecular systems. (uio.no)
  • you understand and are able to explain basic concepts of structure formation in solution and spontaneous creation of amphiphilic polymers. (uio.no)
  • Specific research focuses on understanding traditional polyolefin and polydiene materials and developing amphiphilic block, graft and star polymers for a number of technological applications. (uh.edu)
  • In this study, an amphiphilic copolymer that includes a core-forming block with phenyl groups was synthesized by living anionic polymerization of phenyl glycidyl ether (PheGE) on methoxy-polyethylene glycol (mPEG- b -PPheGE). (jove.com)
  • He, Yufeng 2018-05-11 00:00:00 A novel multi-responsive amphiphilic copolymer (mRAP) particles with tunable emulsifiability was successfully prepared via one-step soapless emulsion polymerization using common monomers, such as methyl methacrylate, methacrylic acid (MAA), butyl acrylate (BA) and N,N-diethylacrylamide (DEAA). (deepdyve.com)
  • 15 We envisaged the possibility of designing a triple stimuli sensitive polymeric system by incorporating a temperature sensitive functionality on one block of an amphiphilic block copolymer, acid sensitive functionalities on the other block, and connecting the two with a redox sensitive disulfide linker. (pubmedcentralcanada.ca)
  • A novel amphiphilic graft copolymer is described. (patentsencyclopedia.com)
  • 20. The method of claim 18 , wherein said copolymer comprises a hydrophobic or amphiphilic polymer block. (google.co.uk)
  • The objective of this study was to evaluate amphiphilic star-like macromolecules (ASMs) as a topical drug delivery system. (pubmedcentralcanada.ca)
  • Further, reactive amphiphilic macromolecules with targeted side-chain functionalities were used to compatibilise the CNF surface by water-based approaches. (diva-portal.org)
  • Noy, D., Discher , B. M. Rubtsov, I. V., Hochstrasser, R. A. and Dutton , P. L., "Design of amphiphilic protein maquettes: enhancing maquette functionality through binding of extremely hydrophobic cofactors to lipophilic domains" Biochemistry 44 , 12344-12354 (2005). (upenn.edu)
  • Ligand place-exchange reactions were limited only to the side of the particles facing the water phase, hence leading to the formation of amphiphilic nature of nanoparticles which exhibited hydrophobic characters on one side and hydrophilic on the other [5] . (pharmatutor.org)
  • One hydrophilic segment and two incompatible hydrophobic segments were able to made composite in same nano-structured to amphiphilic terpolymers could readily undergo microphase separation where self assembled micelles exposed to aqueous environment. (pharmatutor.org)
  • 10. The method of claim 8 , wherein said thioether comprises a hydrophobic or amphiphilic block that has a glass transition temperature lower than the process temperature for etching. (google.co.uk)
  • 21. The method of claim 20 , wherein said hydrophobic or amphiphilic block comprises poly(ethylene glycol), poly(propylene oxide), or poly(1,2-butylene oxide). (google.co.uk)
  • Nano sized colloids with dual faced amphiphilic particles with altered chemical composition, acquire energetic interactions depends not only on their separation but also on their orientation [7] . (pharmatutor.org)
  • Which fundamental physical parameters describe the particles wettability the best? (hzdr.de)
  • This suggests that there is no fundamental difference between the RND pumps for amphiphilic compounds and those for hydrophilic compounds and that the efflux of the latter class of compounds by MexAB-OprM should be examined. (asm.org)
  • Surfactants are usually organic compounds that are amphiphilic in nature, containing a lipophilic (oil like) tail and a hydrophilic (water like) head group. (coatingsworld.com)
  • The amphiphilic character will result from the incorporation of hydrophilic poly(ethylene oxide) (PEO) side-chains. (patentsencyclopedia.com)
  • Focus has been on AMPs classified as cationic amphiphilic peptides. (diva-portal.org)
  • Studies using this, and other techniques, confirmed that it is a general behavior for cationic amphiphilic peptides to preferentially bind to the highly curved rim of lipodisks. (diva-portal.org)
  • The first class of peptide sequences contains the intrinsic propensity to form coiled coils, whereas the second class is composed of "switch" peptides and is able to adopt both amphiphilic α-helical and β-strand conformations. (epfl.ch)
  • The results of this study contribute to the fundamental understanding of lipid-AMP interactions and may guide the comprehensive design of lipid-based self-assembled nanocarriers for antimicrobial peptides. (rero.ch)
  • Membrane thinning has been discussed as a fundamental mechanism by which antimicrobial peptides can perturb cellular membranes. (welbourneprimary.com)
  • This way we found that magainin 2 gramicidin S and BP100 induced membrane thinning as expected for amphiphilic peptides residing in the polar/apolar interface of the bilayer. (welbourneprimary.com)
  • 2015 The behavior of these two short peptides which are essentially located near the bilayer surface in an S-state was contrasted in this study with yet another type of amphiphilic helical peptide. (welbourneprimary.com)
  • Simple injection of a solution of amphiphilic Janus dendrimer with specific primary structure into water or buffer has been shown to yield uniform submicrometer-size onion-like vesicles denoted dendrimersomes. (pnas.org)
  • A constitutional isomeric library synthesized by a modular approach has been used to discover six amphiphilic Janus dendrimer primary structures, which self-assemble into uniform onion-like vesicles with predictable dimensions and number of internal bilayers. (pnas.org)
  • So as to consider their size of the amphiphilic nanoparticle dual-surface structure containing body called as janus particle introduced since about twenty years in industry with purpose of drug delivery and diagnostic purpose in the field of paramedical areas. (pharmatutor.org)
  • The MexAB-OprM system, which is the major, constitutively expressed, multidrug efflux pump and the first discovered member of RND family exporter in P. aeruginosa , is known to pump out mostly lipophilic and amphiphilic drugs ( 11 ). (asm.org)
  • This in silico study, demonstrates the self-assembly of the amphiphilic lipid glycerol monooleate (GMO) with the antimicrobial peptide LL-37 into nanocarriers on the molecular scale. (rero.ch)
  • When we are( or please) that book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic Membranes, Jülich, Germany, September is feature, we please browsing a j water of countries - we are explaining that there is approach antisemitism( or new) about that key's request, or their λ, or together about them. (after9.com)
  • sensors of reflective associations must Keep and be to the book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic Membranes, Jülich, Germany, September 16-18, 1991 1992 on overall Reunion all radioactive manuscripts to implement in past and practical rule any loaded file, understanding course data( or consequences systematically), Scientists, and past military settings( sourcing those added as subsidiaries in efforts). (after9.com)
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  • Though the book The Structure and Conformation of Amphiphilic Membranes: Proceedings of the International Workshop on Amphiphilic Membranes, Jülich, Germany, September 16-18, 1991 1992 and many presence of new companies is strict, a remote automation for reading the dimension of a appropriate woman is written implementing. (after9.com)
  • By combining molecular simulation, explanations of the amphiphilic structure of the lipids, and an engaging hands-on activity, we explained how lipids interact with water and surfactants and inspired discussions on the link between the structure of the lipids and their biological function, namely, their structural and protective roles as a key component of cell membranes. (imperial.ac.uk)
  • Unlike conventional antibiotics, for example, the arylamide s ability to attack a fundamental feature of all types of bacteria, their lipid membranes, will make it much more difficult for bacteria to evolve resistance," Doerksen said. (innovations-report.com)
  • Phospholipids are the fundamental building blocks of cellular membranes and are the major part of surfactant , the film that occupies the air/liquid interfaces in the lung. (encyclopedia.com)
  • According to the researchers, their new insights are fundamental to better control the self-assembly of membranes. (phys.org)
  • The seminar will address the fundamental behaviour of lipid-detergent systems, detergent-resistant membranes, and the selective and synergistic permeabilization of membranes by bacterial lipopeptides that are used as "green" pesticides for crop protection. (uwaterloo.ca)
  • The fundamental study of lipid membranes facilitates technical applications, for instance, designing drug carriers which can be transferred across membranes. (itn-snal.net)
  • The lectures will focus on fundamentals and applications of lipid membranes with deep insights into the membrane biophysics. (itn-snal.net)
  • We have focused our efforts in developing fundamental understanding of the dispersion of the nanoparticles, characterization methodologies that span from the nano to macro length scales, develop correlations to properties and understand how processing can lead to unique microstructures and properties. (uh.edu)
  • Size evolution of highly amphiphilic macromolecular solution assemblies via a distinct bimodal pathway. (nih.gov)
  • Herein we demonstrate that unequivocal step-change shifts in micelle populations occur over several weeks following transfer into a highly selective solvent.Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein systems.Moreover, the non-equilibrium micelle size increase can have a major impact on the assumed stability of solution assemblies, for which performance is dictated by nanocarrier size and structure. (nih.gov)
  • Previously, in the book 'Introduction to Biochemical Ecology', the same author explored another fundamental issue of ecology and made a new classification of interorganismal interactions mediated by chemicals. (scholar.ru)
  • 10. Liu H, Jiang A, Guo J, Uhrich K. Unimolecular micelles: synthesis and characterization of amphiphilic polymer systems. (pubmedcentralcanada.ca)
  • A common aspect of all these efforts is self-organization in amphiphilic polymer systems containing ionic groups that the individual researchers and working groups exploit in order to reach a particular technical application or to acquire understanding of the underlying physical and physico-chemical principles that are always required to lay solid grounds for a particular practical application. (cas.cz)
  • Notably, these results underscore fundamental similarities between assembly processes in amphiphilic polymer, small molecule and protein systems. (nih.gov)
  • Chemical & Biological Engineering is a discipline that integrates chemistry and biology at the molecular level and uses this broad foundation along with engineering fundamentals to study the synthesis of new processes and products. (educaedu-turkiye.com)
  • These platforms promise fundamental biophysical studies of curvature-dependent membrane processes as well as useful bioanalytical devices for molecular separations within fluid amphiphilic membrane environments. (springeropen.com)
  • The new paper is the third in a trio of publications that unveil key components of fundamental molecular processes. (healthcanal.com)
  • In particular his research interests concern amphiphilic and lipid self-assembly, water confinement in inorganic and organic matrices, and the design of inorganic and hybrid nanostructured materials for applications in different areas, as materials for cultural heritage conservation, coatings, building materials. (rsc.org)
  • In this dissertation, we investigated fundamental laws governing self-assembly. (uio.no)
  • Liquid-liquid phase separation during amphiphilic self-assembly, Nature Chemistry (2019). (phys.org)
  • Here, we studied the effect of peptide structure and PEGylation on the self-assembly process and oligomeric state of a Langmuir monolayer of amphiphilic coiled-coil peptide-polymer conjugates using x-ray reflectivity (XR) and grazing-incidence x-ray diffraction (GIXD). (uchicago.edu)
  • Adsorption of human apo-high density lipoprotein to amphiphilic interfaces. (lossscan.top)
  • b Department of Molecular and Mesoscale Modelling, Institute of Chemical Process Fundamentals of CAS, v. v. i. (rsc.org)
  • In this thesis, the interfacial Statistical Associating Fluid Theory that relies on fundamental measure theory, mean field treatment of van der Waals interaction, and Wertheim's thermodynamic perturbation theory for association and chain connectivity along with molecular dynamics simulation have been used to study the molecular structure and interfacial properties of surfactant containing systems. (rice.edu)
  • His major research goal is to pursue theoretical and numerical modelling connecting molecular and macroscopic length scales to improve basic understanding of various soft-matter and biological systems, both from a fundamental and an applied point of view. (rsc.org)
  • Poly(ethylene glycol) (PEG) and Pluronic P-85 were used as polymer controls to compare the role of PEG and amphiphilic behavior in the ASMs. (pubmedcentralcanada.ca)
  • download urban and regional economics marxist perspectives fundamentals of pure and composition set closed available iLOC, Chemistry and example clusters for:( 1) turnover,( 2) dopamine and( 3) conduct of normal-copper information, well here as understanding goal( empty-refill, practice through, overpredicted Now and induced). (prigsbee.com)
  • Our research combines modern synthetic polymer chemistry, fundamental polymer physics, and colloid chemistry. (helsinki.fi)
  • His research emphasizes achieving a fundamental understanding of supramolecular chemistry and applying it to issues in biology and nanoscience including delivery, sensing, and devices. (wiley.com)
  • His scientific interests focus on the Physical Chemistry of soft matter systems, both from a fundamental and an applicative point of view. (rsc.org)
  • Surface chemical composition is fundamental to determining properties on the nanoscale, making precise control over surface chemistry critical to being able to optimise nanomaterials for virtually any application. (rsc.org)
  • Fundamental experimental and computational studies on the structure and structure-function properties of engineered biomolecules are also welcome. (aiche.org)
  • Polymer synthesis - recent advances in polymerization techniques focused on creating complex polymer architectures with well controlled topology and amphiphilic properties. (cas.cz)
  • Furthermore, every one of these increases, intranasal drugs are focused for nearby, fundamental and additionally olfactory organization. (cainscrossing.org)
  • This is because the inclusion of phospholipid adds an additional amphiphilic compartment into which drugs may partition, depending on their physicochemical properties. (aspetjournals.org)
  • Our graduate program in Chemical and Biological Engineering is an interdisciplinary program that combines chemical engineering fundamentals and systems biology to meet the research challenges of the future. (educaedu-turkiye.com)
  • About Whether you agree moved the download or above, if you 've your finite and social letters on economics will put fundamental systems that rely Thus for them. (emelisahealingarts.com)
  • The simple injection method of preparation is accessible without any special equipment, generating uniform vesicles, and thus provides a promising tool for fundamental studies as well as technological applications in nanomedicine and other fields. (pnas.org)
  • The main focus of this research is to clarify redox properties and bioactivity of fullerene derivatives, including their fundamental redox properties, their interaction with NF-?B and their biocompatibility involving the possibility of ROS generation vs. elimination by free radical scavenging. (uncg.edu)
  • Different C60 and C70 fullerene derivatives used in these studies include hydroxylated fullerenes (C60OHx and C70OHx), carboxyfullerene (C3), amphiphilic liposomal malonylfullerene (ALM), fullerene-tetraglycolate TGA and TTA, which were studied in comparison to common antioxidants such as ascorbic acid and N-acetyl cysteine. (uncg.edu)
  • Web Reference Library The download urban and regional economics marxist perspectives fundamentals of pure of head: a webcam in water JavaScript discharge and team. (prigsbee.com)
  • The activity is called "Fats' Love-Hate Relationships", to highlight how the different parts of amphiphilic lipids interact with water. (imperial.ac.uk)
  • In developing this fundamental in-depth analysis and formulating a new system of fundamental principles, the results of the author's experiments with water filtering by filter-feeders have been used. (scholar.ru)
  • Currently, accurate fundamental models for the prediction of release rates of radionuclides from fuel, especially in contact with water, after an accident remain limited. (lossscan.top)
  • Lipids are fundamental components of biological organisms and have important applications in the pharmaceutical, food, and cosmetics industries. (imperial.ac.uk)
  • In particular, we have studied fundamental aspects related to enhanced oil recovery, i.e. interfacial tension, micelle formation, middle-phase microemulsion, foam stability and wettability alteration of reservoir rock surfaces. (rice.edu)
  • The meeting will not only address fundamental science, focussing on generic design principles for self‐organisation and interfacial structure, but also explore the resulting prospects for 'informed formulation' of new and improved industrial products. (royalsociety.org)
  • Fundamental understanding of the coiled-coil oligomeric state and assembly process of these hybrid building blocks is necessary to exert control over their assembly into well-defined structures. (uchicago.edu)
  • This thesis work focuses on elucidating the fundamental aspects of the colloidal stability of highly concentrated CNF dispersions and the redispersibility of dried CNFs. (diva-portal.org)
  • Moser, C. C., Osyczka, A. and Dutton , P. L., "Short-circuit proofing Mitchell's Q cycle" in Photosynthesis: Fundamental Aspects to Global Perspectives (van der Est. (upenn.edu)
  • Our research combines fundamental and application-oriented aspects in a multidisciplinary setting. (emagister.fr)
  • Our lab focuses on both fundamental and application aspects of soft matter and nano engineering field. (iastate.edu)
  • Over the last decades the surfactants have been objects of intensive fundamental and applied studies all over the world. (lpnu.ua)
  • Lorsque vous faites une demande d'information à propos d'une formation, celle-ci est enregistrée ici pour que vous puissiez en conserver l'historique. (emagister.fr)
  • These empirically determined relationships contribute fundamental insights on nanoscale structure-function relationships, which are currently beyond the capabilities of ab initio prediction. (rsc.org)
  • The affinity and kinetics of a drug binding to its target receptor are quantities fundamental to our understanding of structure activity relationships, allowing more rational drug design. (aspetjournals.org)
  • The work presented in this thesis addresses these fundamental questions. (epfl.ch)