Magnetic Resonance Imaging: Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.Gyrus Cinguli: One of the convolutions on the medial surface of the CEREBRAL HEMISPHERES. It surrounds the rostral part of the brain and CORPUS CALLOSUM and forms part of the LIMBIC SYSTEM.Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM.DibenzothiazepinesOverlearning: Learning in which practice proceeds beyond the point where the act can just be performed with the required degree of excellence.Lithium: An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Television: The transmission and reproduction of transient images of fixed or moving objects. An electronic system of transmitting such images together with sound over a wire or through space by apparatus that converts light and sound into electrical waves and reconverts them into visible light rays and audible sound. (From Webster, 3rd ed)Videotape Recording: Recording of visual and sometimes sound signals on magnetic tape.Video Games: A form of interactive entertainment in which the player controls electronically generated images that appear on a video display screen. This includes video games played in the home on special machines or home computers, and those played in arcades.Peer Review, Research: The evaluation by experts of the quality and pertinence of research or research proposals of other experts in the same field. Peer review is used by editors in deciding which submissions warrant publication, by granting agencies to determine which proposals should be funded, and by academic institutions in tenure decisions.Research: Critical and exhaustive investigation or experimentation, having for its aim the discovery of new facts and their correct interpretation, the revision of accepted conclusions, theories, or laws in the light of newly discovered facts, or the practical application of such new or revised conclusions, theories, or laws. (Webster, 3d ed)Brain Chemistry: Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.Face: The anterior portion of the head that includes the skin, muscles, and structures of the forehead, eyes, nose, mouth, cheeks, and jaw.Perceptual Distortion: Lack of correspondence between the way a stimulus is commonly perceived and the way an individual perceives it under given conditions.Pattern Recognition, Visual: Mental process to visually perceive a critical number of facts (the pattern), such as characters, shapes, displays, or designs.Photic Stimulation: Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.Visual Perception: The selecting and organizing of visual stimuli based on the individual's past experience.Recognition (Psychology): The knowledge or perception that someone or something present has been previously encountered.Multimedia: Materials, frequently computer applications, that combine some or all of text, sound, graphics, animation, and video into integrated packages. (Thesaurus of ERIC Descriptors, 1994)Imagination: A new pattern of perceptual or ideational material derived from past experience.Imagery (Psychotherapy): The use of mental images produced by the imagination as a form of psychotherapy. It can be classified by the modality of its content: visual, verbal, auditory, olfactory, tactile, gustatory, or kinesthetic. Common themes derive from nature imagery (e.g., forests and mountains), water imagery (e.g., brooks and oceans), travel imagery, etc. Imagery is used in the treatment of mental disorders and in helping patients cope with other diseases. Imagery often forms a part of HYPNOSIS, of AUTOGENIC TRAINING, of RELAXATION TECHNIQUES, and of BEHAVIOR THERAPY. (From Encyclopedia of Human Behavior, vol. 4, pp29-30, 1994)Encyclopedias as Topic: Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)Cannibalism: Eating other individuals of one's own species.Rejection (Psychology): Non-acceptance, negative attitudes, hostility or excessive criticism of the individual which may precipitate feelings of rejection.Eidetic Imagery: A visual image which is recalled in accurate detail. It is a sort of projection of an image on a mental screen.Alexander Disease: Rare leukoencephalopathy with infantile-onset accumulation of Rosenthal fibers in the subpial, periventricular, and subependymal zones of the brain. Rosenthal fibers are GLIAL FIBRILLARY ACIDIC PROTEIN aggregates found in ASTROCYTES. Juvenile- and adult-onset types show progressive atrophy of the lower brainstem instead. De novo mutations in the GFAP gene are associated with the disease with propensity for paternal inheritance.Neurosciences: The scientific disciplines concerned with the embryology, anatomy, physiology, biochemistry, pharmacology, etc., of the nervous system.Longevity: The normal length of time of an organism's life.Carboxy-Lyases: Enzymes that catalyze the addition of a carboxyl group to a compound (carboxylases) or the removal of a carboxyl group from a compound (decarboxylases). EC 4.1.1.Glial Fibrillary Acidic Protein: An intermediate filament protein found only in glial cells or cells of glial origin. MW 51,000.Neurobiology: The study of the structure, growth, activities, and functions of NEURONS and the NERVOUS SYSTEM.Famous PersonsReward: An object or a situation that can serve to reinforce a response, to satisfy a motive, or to afford pleasure.Anticipation, Psychological: The ability to foresee what is likely to happen on the basis of past experience. It is largely a frontal lobe function.Dopamine: One of the catecholamine NEUROTRANSMITTERS in the brain. It is derived from TYROSINE and is the precursor to NOREPINEPHRINE and EPINEPHRINE. Dopamine is a major transmitter in the extrapyramidal system of the brain, and important in regulating movement. A family of receptors (RECEPTORS, DOPAMINE) mediate its action.Dopamine Plasma Membrane Transport Proteins: Sodium chloride-dependent neurotransmitter symporters located primarily on the PLASMA MEMBRANE of dopaminergic neurons. They remove DOPAMINE from the EXTRACELLULAR SPACE by high affinity reuptake into PRESYNAPTIC TERMINALS and are the target of DOPAMINE UPTAKE INHIBITORS.Saint Vincent and the Grenadines: A self-governing state of the Windward Islands in the West Indies, comprising Saint Vincent and the northern islets of the Grenadines. Its capital is Kingstown. It is one of the original homes of the Carib Indians supposed to have been sighted by Columbus in 1498. It was in English hands from 1627 till held by the French 1779-83. Saint Vincent subsequently became a British possession and, with other nearby British territories, was administered by the Governor of the Windward Islands till 1959. It attained a measure of independence in 1969 but achieved full independence as Saint Vincent and the Grenadines in 1979. Saint Vincent was the 4th century Spanish martyr on whose feast day Columbus discovered the island. Grenadines is derived from the Spanish kingdom of Granada. (From Webster's New Geographical Dictionary, 1988, p1054 & The Europa World Year Book 1993, p2441)Receptors, Dopamine D2: A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. D2-class receptor genes contain INTRONS, and the receptors inhibit ADENYLYL CYCLASES.Anticipation, Genetic: The apparent tendency of certain diseases to appear at earlier AGE OF ONSET and with increasing severity in successive generations. (Rieger et al., Glossary of Genetics: Classical and Molecular, 5th ed)Myasthenia Gravis: A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)Congresses as Topic: Conferences, conventions or formal meetings usually attended by delegates representing a special field of interest.Exhibits as Topic: Discussions, descriptions or catalogs of public displays or items representative of a given subject.Persons: Persons as individuals (e.g., ABORTION APPLICANTS) or as members of a group (e.g., HISPANIC AMERICANS). It is not used for members of the various professions (e.g., PHYSICIANS) or occupations (e.g., LIBRARIANS) for which OCCUPATIONAL GROUPS is available.MissouriPharmacopoeias as Topic: Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.International Cooperation: The interaction of persons or groups of persons representing various nations in the pursuit of a common goal or interest.Limulus Test: Sensitive method for detection of bacterial endotoxins and endotoxin-like substances that depends on the in vitro gelation of Limulus amebocyte lysate (LAL), prepared from the circulating blood (amebocytes) of the horseshoe crab, by the endotoxin or related compound. Used for detection of endotoxin in body fluids and parenteral pharmaceuticals.Vital Signs: The signs of life that may be monitored or measured, namely pulse rate, respiratory rate, body temperature, and blood pressure.Translational Medical Research: The application of discoveries generated by laboratory research and preclinical studies to the development of clinical trials and studies in humans. A second area of translational research concerns enhancing the adoption of best practices.Periodicals as Topic: A publication issued at stated, more or less regular, intervals.Publishing: "The business or profession of the commercial production and issuance of literature" (Webster's 3d). It includes the publisher, publication processes, editing and editors. Production may be by conventional printing methods or by electronic publishing.Journal Impact Factor: A quantitative measure of the frequency on average with which articles in a journal have been cited in a given period of time.Health Systems Agencies: Health planning and resources development agencies which function in each health service area of the United States (PL 93-641).

*Creative visualization

... a functional magnetic resonance imaging study. Neuroscience, Vol. 152, No. 1,2008, pp29-39. Juttner, M., and Rentschler, I., ... Behavioral and Brain Sciences, Vol. 25, No. 2, 2002, pp197-198. Juttner, M., and Rentschler, I., Imagery in multi-modal object ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. Kosslyn, S. M., Image ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. Kosslyn, S. M., Ganis, G ...

*Creative visualization

... a functional magnetic resonance imaging study. Neuroscience, Vol. 152, No. 1,2008, pp29-39. ... Behavioral and Brain Sciences, Vol. 25, No. 2, 2002, pp197-198.. *^ Juttner, M., and Rentschler, I., Imagery in multi-modal ... The brain is capable of creating other types of mental imagery, in addition to visual images, simulating or recreating ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. ...

*Biological psychopathology

... and functional magnetic resonance imaging (fMRI) scans, as well as genetic studies. Together, neuroimaging with multimodal PET/ ... revealing how the differences in behaviorally-relevant brain activations can arise from underlying variations in certain brain ...

*Electroencephalography functional magnetic resonance imaging

... is a multimodal neuroimaging technique whereby EEG and fMRI data are recorded synchronously for the study of electrical brain ... and functional Magnetic Resonance Imaging (fMRI)". Magnetic Resonance Imaging. 28 (8): 1192-1199. doi:10.1016/j.mri.2010.01.001 ... EEG-fMRI (short for EEG-correlated fMRI or electroencephalography-correlated functional magnetic resonance imaging) ... ability to image blood dynamics through the entire brain with high spatial resolution. Up to now, EEG-fMRI has been mainly seen ...

*Psikoza

"Functional Magnetic Resonance Imaging Correlates of First-Episode Psychoses during Attentional and Memory Task Performance". ... "Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic ... "Functional Brain Imaging in Schizophrenia: Selected Results and Methods". In Swerdlow, Neal. Behavioral Neurobiology of ... "Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic ...

*Arno Villringer

... using multimodal brain imaging, e.g., signatures of neuronal inhibition in functional brain imaging (Wenzel et al. 2000, ... Perfusion Imaging: Arno Villringer pioneered magnetic resonance perfusion imaging of the brain by demonstrating that ... signal in functional magnetic resonance imaging (fMRI). Optical Imaging: In 1993, Villringer showed feasibility of noninvasive ... Dynamic imaging with Lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects. Magnetic Resonance ...

*Steven Laureys

... functional magnetic resonance imaging (fMRI), structural MRI, electroencephalography (EEG), event related potential (ERP) and ... neuronal plasticity in severely brain damaged patients with altered states of consciousness by means of multimodal functional ... It aims at characterizing the brain structure and the residual cerebral function in patients who survive a severe brain injury ... unconsciousness and the brain", Laureys S Nature Reviews Neuroscience, 11 (2005) 899-909 "Brain function in coma, vegetative ...

*Brodmann area 19

Functional magnetic resonance imaging shows the existence of various retinotopic maps within area 19. In general, the diverse ... Brodmann area 19, or BA 19, is part of the occipital lobe cortex in the human brain. Along with area 18, it comprises the ... and multimodal integrating functions. This area is also known as peristriate area 19, and it refers to a subdivision of the ... Brodmann area List of regions in the human brain Hyvarinen, J., Carlson, Y. and Hyvarinen, L. (1981) Early visual deprivation ...

*History of neuroimaging

Functional magnetic resonance imaging (fMRI) was born. Since the 1990s, fMRI has come to dominate the brain mapping field due ... Multimodal imaging combines existing brain imaging techniques in synergistic ways which facilitate the improved interpretation ... The combined use of MEG and functional magnetic resonance imaging was first reported in 1999. It combines the spatial ... and nuclear magnetic resonance. To begin with, much of the recent progress has had to do not with the actual brain imaging ...

*Preclinical imaging

Principle: Magnetic Resonance Imaging (MRI) exploits the nuclear magnetic alignments of different atoms inside a magnetic field ... provide multi-modal systems combining the advantages of anatomical modalities such as CT and MR with the functional imaging of ... Micro-PAT can image the brain with high spatial resolution, detect molecular targeted contrast agents, simultaneously quantify ... magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging ( ...

*Eating disorder

2002). "Effects on the brain of a psychological treatment: cognitive remediation therapy: functional magnetic resonance imaging ... Mikami, AY; Hinshaw, SP; Arnold, LE; Hoza, B; Hechtman, L (2010). "Bulimia nervosa symptoms in the multimodal treatment study ... The way the media presents images can have a lasting effect on an individual's perception of their body image. Eating disorders ... Chipkevitch, E (1994). "Brain tumors and anorexia nervosa syndrome". Brain & development. 16 (3): 175-9. doi:10.1016/0387-7604( ...

*Auditory spatial attention

2002). Acoustic noise and functional magnetic resonance imaging: current strategies and future prospects. Journal of magnetic ... suggesting functional overlap with portions of the brain previously shown to be responsible for visual attention. Several ... The cognitive consequences of this connection, which may relate to multimodal processing, have yet to be fully explored. ... Neuroimaging tools of modern cognitive neuroscience such as functional magnetic resonance imaging (fMRI) and event-related ...

*Functional integration (neurobiology)

Main article: Functional magnetic resonance imaging Functional magnetic resonance imaging (fMRI) is a form of MRI that is most ... Main article: Multimodal imaging Multimodal imaging frequently consists of the coupling of an electrophysiologic measurement ... In functional integration, there is a distinction drawn between functional connectivity, and effective connectivity. Two brain ... Characterizing Functional Asymmetries with Brain Mapping. The asymmetrical brain. Bradford Books Series. Cambridge, Mass: MIT ...

*Chromesthesia

Functional magnetic resonance imaging studies also implicate the left superior temporal sulcus as being involved in the ... or they may reflect feedback pathways from multimodal audiovisual regions to unimodal visual regions present in all brains. The ... This brain region responds most strongly to congruent pairs of visual and auditory information, such as congruent lip movements ... This is most apparent in grapheme-color synesthesia, because the brain regions for color processing and visual word form ...

*Anders Dale

... event related functional magnetic resonance imaging (fMRI) (with Randy Buckner at Harvard), b) an in vivo method to quantify ... He is the founding Director of the Center for Multimodal Imaging Genetics (CMIG) at UCSD. Dale founded and initially developed ... The study made use of "sophisticated gene-mapping tools and imaging technology to collect a wealth of data about brain ... Fischl, B.; Dale, A. M. (2000). "Measuring the thickness of the human cerebral cortex from magnetic resonance images". ...

*Large deformation diffeomorphic metric mapping

... or functional imagery such as temporal data of functional magnetic resonance imaging and scalar densities such as Positron ... In CA mapping of dense information measured within Magnetic resonance image (MRI) based coordinate systems such as in the brain ... generally termed multi-modal medical imagery, providing either scalar and or vector quantities at each spatial location. ... Examples are scalar T1 or T2 Magnetic resonance imagery, or as 3x3 diffusion tensor matrices Diffusion MRI and Diffusion- ...

*Medical image computing

Functional magnetic resonance imaging (fMRI) is a medical imaging modality that indirectly measures neural activity by ... "Three-dimensional tracking of axonal projections in the brain by magnetic resonance imaging". Annals of Neurology. 45 (2): 265- ... Multi-modal registration requires a more sophisticated similarity measure; alternatively, a different image representation can ... "Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging". Magnetic Resonance in Medicine. 54 (6 ...

*3DSlicer

... as well as advanced image analysis algorithms for diffusion tensor imaging, functional magnetic resonance imaging and image- ... registration and three-dimensional visualization of multimodal image data, ... using MRI to assess blood flow in the brain related to neural or spinal cord activity), DTI (using MRI to measure the ... "3D Slicer as an image computing platform for the Quantitative Imaging Network". Magnetic Resonance Imaging. 30 (9): 1323-41. ...

*Psychosis

"Functional Magnetic Resonance Imaging Correlates of First-Episode Psychoses during Attentional and Memory Task Performance". ... "Multimodal meta-analysis of structural and functional brain changes in first episode psychosis and the effects of antipsychotic ... Brown G, Thompson W. "Functional Brain Imaging in Schizophrenia: Selected Results and Methods". In Swerdlow N (ed.). Behavioral ... The first brain image of an individual with psychosis was completed as far back as 1935 using a technique called ...

*Athinoula A. Martinos Center for Biomedical Imaging

... molecular imaging and transcranial magnetic stimulation. A particular area of innovation at the Center is Multimodal Functional ... New magnetic resonance imaging (MRI) and spectroscopy sequences are developed in conjunction with Martinos, Harvard, and MIT ... Migraine Tied to Thickening in Brain Area The Washington Post: Scientists Probe the Idle Mind. ... The core technologies being developed and used at the Center are magnetic resonance imaging (MRI) and spectroscopy (MRS), ...

*Resting state fMRI

Resting-state functional magnetic resonance imaging (rfMRI) can image low-frequency fluctuations in the spontaneous brain ... 2012). "Atlas-based analysis of resting-state functional connectivity: Evaluation for reproducibility and multi-modal anatomy- ... Functional magnetic resonance imaging (functional MRI or fMRI) is a specific magnetic resonance imaging (MRI) procedure that ... 3.0.co;2-7. Friston, K (2009). "Causal Modelling and Brain Connectivity in Functional Magnetic Resonance Imaging. [Editorial ...

*Task-negative

"An Event-Related Functional Magnetic Resonance Imaging Study of Voluntary and Stimulus-Driven Orienting of Attention". Journal ... Downar, J.; Crawley, A. P.; Mikulis, D. J.; Davis, K. D. (2000). "A multimodal cortical network for the detection of changes in ... Posner, M. I.; Petersen, S. E. (1990). "The Attention System Of The Human Brain". Annual Review of Neuroscience. 13: 25-42. doi ... Astafiev, S. V.; Shulman, G. I.; Stanley, C. M.; Snyder, A. Z.; Van Essen, D. C.; Corbetta, M. (2003). "Functional organization ...

*Default mode network

... exhibiting synchronicity in functional magnetic resonance imaging (fMRI) scans while not engaged in any task. [11] [12] ... in brain activities and an accurate detection of autism spectrum disorder using resting state functional-magnetic resonance ... "Neural correlates of the LSD experience revealed by multimodal neuroimaging". Proceedings of the National Academy of Sciences ... Deep brain stimulation - Alterations in brain activity with deep brain stimulation may be used to balance resting state ...

*Aftertaste

Functional magnetic resonance images of the blood flow in the subjects' brains were recorded before and after they swallowed ... doi:10.1007/s00221-005-2376-9. Verhagen, J. V.; Engelen, L. (2006). "The neurocognitive bases of human multimodal food ... when human subjects were exposed to a taste stimulus and their cerebral blood flow measured with magnetic resonance imaging. ... Shepherd, G. M. (2006). "Smell images and the flavour system in the human brain". Nature. 444 (7117): 316-321. doi:10.1038/ ...

*List of neuroscience databases

The Functional Magnetic Resonance Imaging Data Center (fMRIDC): the challenges and rewards of large-scale databasing of ... "Pain and Interoception Imaging Network: A multimodal, multisite, brain-imaging repository for chronic somatic and visceral pain ... imaging data, such as postmortem brain sections or 3D MRI and fMRI images. Some focus on the human brain, others on non-human. ... 2008). "The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods". Journal of Magnetic Resonance Imaging. 27 (4): ...

*Behavioral neuroscience

fMRI - Functional magnetic resonance imaging, a technique most frequently applied on human subjects, in which changes in ... Measuring the magnetic fields created by the electric current flowing within the neurons identifies brain activity associated ... "Multimodal fast optical interrogation of neural circuitry." Nature. Vol 446. 5 April 2007. doi:10.1038/nature05744 Chow, B. Y. ... It can monitor brain development and cognitive engagement. Functional neuroanatomy - A more complex counterpart of phrenology. ...

*Orbitofrontal cortex

Using functional magnetic resonance imaging (fMRI) to image the human OFC is a challenge, because this brain region is in ... A recent multi-modal human neuroimaging study shows disrupted structural and functional connectivity of the OFC with the ... Brain imaging studies show that during cocaine withdrawal, metabolism is increased in the OFC and that this is proportional to ... However, in heroin addiction, neuroimaging study shows that brain resting-state functional connectivity in the OFC is enhanced ...
Author(s): Connolly, CG; Wu, J; Ho, TC; Hoeft, F; Wolkowitz, O; Eisendrath, S; Frank, G; Hendren, R; Max, JE; Paulus, MP; Tapert, SF; Banerjee, D; Simmons, AN; Yang, TT | Abstract: Background Very few studies have been performed to understand the underlying neural substrates of adolescent major depressive disorder (MDD). Studies in depressed adults have demonstrated that the subgenual anterior cingulate cortex (sgACC) plays a pivotal role in depression and have revealed aberrant patterns of resting-state functional connectivity (RSFC). Here, we examine the RSFC of the sgACC in medication-naïve first-episode adolescents with MDD. Methods Twenty-three adolescents with MDD and 36 well-matched control subjects underwent functional magnetic resonance imaging to assess the RSFC of the sgACC. Results We observed elevated connectivity between the sgACC and the insula and between the sgACC and the amygdala in the MDD ...
Differential diagnosis of ovarian cystadenofibromas should include stromal ovarian tumors with fibrous component, struma ovarri, ovarian metastases and endometriomas. Ovarian tumors with fibrous parts, including fibroma, fibrothecoma and Brenner tumor often present with a predominantly solid component of low signal intensity on T2-weighted images [7, 11, 12]. Struma ovarri has been described as multilocular ovarian mass, with variable signal intensity of the cystic parts and coexistence of hypointense areas on T2-weighted images, due to the presence of viscous colloid material [15, 16]. Ovarian metastases with a rich fibrous component, usually originating from the gastrointestinal tract often have areas of low signal intensity on T2-weighted images and display strong enhancement after contrast material administration [17 ...
Posterior reversible encephalopathy syndrome is a clinico-neuroradiological entity characterized by headache, vomiting, altered mental status, blurred vision and seizures with neuroimaging studies demonstrating white-gray matter edema involving predominantly the posterior region of the brain. We report a 47-year-old Caucasian man with liver cirrhosis who developed posterior reversible encephalopathy syndrome following an upper gastrointestinal hemorrhage and who was managed with induced hypothermia for control of intracranial hypertension and continuous veno-venous hemodiafiltration for severe hyperammonemia. We believe this is the first documented case report of posterior reversible encephalopathy syndrome associated with cirrhosis as well as the first report of the use of induced hypothermia and continuous veno-venous hemodiafiltration in this setting.
Examples of coronal cUS and axial MR images performed during the first week after birth in infants presenting with neonatal seizures. (A) HIE: hyperechogenicity in both thalami on cUS and low signal intensity on the ADC map in thalami, optic radiation and splenium of the corpus callosum (D); (B) PAIS of main branch of the left-middle cerebral artery: wedge-shaped hyperechogenicity with a linear demarcation line in the left hemisphere on cUS and low signal intensity on the ADC map in territory of the left-middle cerebral artery, as well as optic radiation and splenium of the corpus callosum (E); (C) haemorrhage in the right temporal lobe recognised on cUS as a round area of hyperechogenicity and on T2WI as an area of low signal intensity surrounded by high signal intensity due to oedema (F).. ...
White matter hyperintensities (WMH) of presumed vascular origin, as seen on T2-weighted fluid attenuated inversion recovery magnetic resonance imaging, are known to increase with age and are elevated in Alzheimers disease (AD). The cognitive implications of these common markers are not well understood. Previous research has primarily focused on global measures of WMH burden and broad localizations that contain multiple white matter tracts. The aims of this study were to determine the pattern of WMH accumulation with age, risk for AD, and the relationship with cognitive function utilizing a voxel-wise analysis capable of identifying specific white matter regions. A total of 349 participants underwent T1-weighted and high-resolution T2-weighted fluid attenuated inversion recovery magnetic resonance imaging and neuropsychological testing. Increasing age and lower cognitive ...
By EDWARD F. JACKSON, PhD. One key advantage of MR is the wide range of intrinsic tissue properties that can be assessed by the appropriate choice of parameters defining the associated measurement technique.. In neuroimaging applications, for example, routine MR imaging provides a qualitative means of assessing the breakdown of the blood brain barrier as reflected by the extent of gadolinium contrast agent extravasation (T1-weighted sequences), the extent of vasogenic edema (T2-weighted and T2-weighted fluid attenuated inversion recovery sequences), the presence of blood products such as hemosiderin, methemoglobin (T1-weighted and T2* susceptibility-weighted images), and the ability to assess brain atrophy and regional white/gray matter abnormalities (using proton density-weighted and/or magnetization prepared gradient-echo sequences).. Neurovascular anatomy can be evaluated with or without the injection of ...
We hypothesized that pediatric patients with type 1 diabetes have cardiac magnetic resonance (CMR) detectable differences in thoracic aortic wall properties and hemodynamics leading to significant local differences in indices of wall shear stress, when compared with age-matched control subjects without diabetes. Pediatric patients with type 1 diabetes were recruited from Childrens Hospital of Wisconsin and compared with controls. All underwent morning CMR scanning, 4-limb blood pressure, brachial artery reactivity testing, and venipuncture. Patient-specific computational fluid dynamics modeling with fluid-structure interaction, based on CMR data, determined regional time-averaged wall shear stress (TAWSS) and oscillatory shear index (OSI). Twenty type 1 diabetic subjects, median age 15.8 years (11.6-18.4) and 8 controls 15.4 years (10.3-18.2) were similar except for higher glucose, hemoglobin A1c, and triglycerides for type 1 diabetic subjects. Lower flow-mediated dilation ...
BACKGROUND AND PURPOSE: White matter hyperintensities (WMH) on MRI are a quantitative marker for sporadic cerebral small vessel disease and are highly heritable. To date, large-scale genetic studies have identified only a single locus influencing WMH burden. This might in part relate to biological heterogeneity of sporadic WMH. The current study searched for genetic modifiers of WMH volume in cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a monogenic small vessel disease.. METHODS: We performed a genome-wide association study to identify quantitative trait loci for WMH volume by combining data from 517 CADASIL patients collected through 7 centers across Europe. WMH volumes were centrally analyzed and quantified on fluid attenuated inversion recovery images. Genotyping was performed using the Affymetrix 6.0 platform. Individuals were assigned to 2 distinct genetic clusters (cluster 1 and cluster 2) based on their genetic background.. RESULTS: ...
abnormal mri - MedHelps abnormal mri Center for Information, Symptoms, Resources, Treatments and Tools for abnormal mri. Find abnormal mri information, treatments for abnormal mri and abnormal mri symptoms.
Imaging of facial nerve schwannomas includes both MRI and CT. On noncontrast temporal bone CT, the findings include a tubular soft tissue mass along the course of the facial nerve with enlargement of the facial nerve canal. The bony margins are usually smooth and benign-appearing. On MRI, these lesions have intermediate to low signal intensity on T1-weighted imaging and high signal intensity on T2-weighted imaging. Following the administration of intravenous gadolinium, facial nerve schwannomas enhance homogenously. The differential diagnosis includes normal intratemporal facial nerve enhancement, Bells palsy, facial nerve hemangioma, and facial nerve perineural parotid malignancy. Based on clinical presentation, facial nerve schwannoma can be distinguished from Bells palsy and a hemangioma by a more gradual onset of facial nerve paralysis vs an acute onset in these other entities. Normal facial nerve ...
TY - CONF. T1 - Reward networks changes in the brain of pathological gamblers: a resting state functional magnetic resonance imaging study. AU - Gagliardo, Cesare. AU - La Barbera, Daniele. AU - Piccoli, Tommaso. AU - Marrale, Maurizio. AU - Lagalla, Roberto. AU - Maniaci, Giuseppe. AU - Cannizzaro, Carla. AU - Collura, Giorgio. AU - La Tona, Giuseppe. PY - 2018. Y1 - 2018. N2 - Aims and objectivesTo investigate functional connectivity changes in pathological gamblers (PGs) in comparison to healthy controls (HCs) by means of resting state functional Magnetic Resonance Imaging (RS-fMRI).Methods and materialsThirteen HCs and fourteen PGs were recruited (all right handed males; drugs free; mean age 35.96±9.56). All subjects underwent brain scan using a 1,5T MRI scanner. Activations data of ...
Primary angiitis of the central nervous system is a rare disease of unclear etiology. There is no single test diagnostic of primary angiitis of the central nervous system. We report an unusual pattern on brain magnetic resonance imaging that might be specific for primary angiitis of the central nervous system. A 47-year-old Caucasian man developed progressive bilateral hand tremor, difficulty walking, cognitive slowing and headache. A physical examination showed bilateral hand tremor with dysmetria, hyperreflexia and abnormal gait. Magnetic resonance imaging of his brain showed bilateral, symmetrical, increased intensity on T2-weighted images concurrent with linear contrast enhancement in a radial distribution throughout his white matter, sparing subcortical regions in his centrum semiovale, corona radiata, basal ganglia and ...
White matter hyperintensities were associated with an increased risk of dementia in the general population, but not in studies on high risk populations (mainly with mild cognitive impairment or a history of stroke). When subtypes of dementia were assessed, the three studies that investigated the relation of white matter hyperintensities with incident vascular dementia found a significant association, both in the general population and in patients with mild cognitive impairment.31 33 41 Conversely, although the meta-analysis testing the relation of white matter hyperintensities with incident Alzheimers disease yielded an overall significant association, this association was driven by the large population based study,31 whereas the two smaller studies on patients with mild cognitive impairment did not identify any association.41 49 Finally, our systematic review suggests that, in most studies looking at the association of white matter hyperintensities with decline in cognitive performance, white ...
TY - JOUR. T1 - Cortical laminar necrosis and CT negative hemorrhage in posterior reversible encephalopathy syndrome. T2 - A case report. AU - Ahmad, Iftikhar. AU - Kralik, S.. AU - Ho, C. Y.. AU - Ammar, T.. AU - Douglas, A. C.. PY - 2012/12. Y1 - 2012/12. N2 - Posterior reversible encephalopathy syndrome (PRES) is a clinicoradiologic condition that typically demonstrates symmetric occipitoparietal vasogenic edema on CT and MR imaging. The vasogenic edema typically resolves over a period of days to weeks if the underlying hemodynamic abnormality is promptly corrected. Less commonly, PRES may be complicated by hemorrhage or cytotoxic edema that restricts diffusion and usually involves the cerebral cortex. Cortical laminar necrosis (CLN) is a sequela of cerebral energy depletion, resulting in selective necrosis of the most metabolically active cortical layers. Cortical hemorrhage is an atypical feature of CLN. We present a unique PRES case with ...
BACKGROUND:Diabetes is a major risk factor for cardiovascular disease. In particular, type 1 diabetes compromises the cardiac function of individuals at a relatively early age due to the protracted course of abnormal glucose homeostasis. The functional abnormalities of diabetic myocardium have been attributed to the pathological changes of diabetic cardiomyopathy.METHODS:In this study, we used high field magnetic resonance imaging (MRI) to evaluate the left ventricular functional characteristics of streptozotocin treated diabetic Sprague-Dawley rats (8 weeks disease duration) in comparison with age/sex matched controls.RESULTS:Our analyses of EKG gated cardiac MRI scans of the left ventricle showed a 28% decrease in the end-diastolic volume and 10% increase in the end-systolic volume of diabetic hearts compared to controls. Mean stroke volume and ejection fraction in diabetic rats were decreased (48% and ...
Magnetic resonance images (MRI) of the brain revealed an intrasellar and suprasellar cystic mass with well defined smooth borders, which displaced the optic chiasm superiorly. The lesion displayed high signal intensity on T1 weighted images (Images 1a and 1b, sagittal and axial, respectively) and showed peripheral enhancement with Gadolinium administration (Image 1c). The lesion also showed high signal intensity on T2 weighted images (Image 1d). A previous brain MRI from 1991 did not reveal sellar or suprasellar lesions. PATHOLOGICAL FINDINGS. FINAL DIAGNOSIS. ...
Differential diagnosis must be done from other cyst-like lesions of that region. PACs arise from the adjacent Meckels cave, and secondary erode into the petrous apex [4], whereas lesions such as cholesteatoma, cholesterol granuloma, mucocele, apical petrositis and petrous apex effusion, arise from the petrous apex and expand it from within [3, 4]. Furthermore, epidermoid cysts have high signal intensity on fluid-attenuation inversion-recovery sequence, whereas the signal of arachnoid cysts is suppressed. Diffusion weighted imaging (DWI) also allows differentiation of epidermoid and arachnoid cysts i.e. epidermoid cysts yield high signal on DWI due to their restricted diffusion while arachnoid cysts, like CSF, show very low signal intensity. In addition, lesions that have high signal intensity on T2W sequences such as paraganglioma, chondroma, chordoma and apex petrositis show contrast enhancement [2 ...
BACKGROUND:Maintaining the quality of magnetic resonance images acquired with the current implantable coil technology is challenging in longitudinal studies. To overcome this challenge, the principle of inductive overcoupling is introduced as a method to tune and match a dual coil system. This system consists of an imaging coil built with fixed electrical elements and a matching coil equipped with tuning and matching capabilities. Overcoupling here refers to the condition beyond which the peak of the current in the imaging coil splits.METHODS:The combined coils are coupled inductively to operate like a transformer. Each coil circuit is electrically represented by equivalent lumped-elements. A theoretical analysis is given to identify the frequency response characteristics of the currents in each coil. The predictions from this analysis are translated into experiments and applied to locally image rat spinal ...
Lactating rats must continuously maintain a critical balance between caring for pups and aggressively responding to nest threats. We tested the neural response of lactating females to the presentation of their own pups and novel intruder males using blood oxygen level-dependent functional magnetic resonance imaging at 7 T. Dams were presented with a single sequence of a control stimulus, pups or a male intruder in one imaging session (n = 7-9). To further determine the selectivity of neural processing, dams were imaged for their response to a male intruder in both the absence and presence of their pups (n = 6). Several maternal cortical and limbic brain regions were significantly activated by intruder presentation but not by pups or a control stimulus. These included the nucleus accumbens, periaqueductal gray, anterior cingulate, anterior thalamus, basal nucleus of the ...
Investigators at Childrens Hospital of Montefiore, Albert Einstein College of Medicine, NY, determined the incidence of posterior reversible encephalopathy syndrome (PRES) in a pediatric critical care unit. Ten patients ,21 years of age with PRES (incidence of 1 in 259 admissions, 0.4%) were studied. Nine patients presented with generalized tonic and/or clonic seizures. Continuous EEG showed generalized slowing but no epileptiform activity. Risk factors included hypertension, cytotoxin medication use, and anemia. Comorbidities included systemic lupus erythematosus, inflammatory bowel disease, ulcerative colitis, liver cirrhosis, pulmonary embolism, renal insufficiency, septic shock, and acute chest syndrome. One-year follow-up showed no residual neurological deficits and resolution of white matter signal abnormalities on neuroimaging. [1]. COMMENT. PRES, also referred to as hypertensive encephalopathy or reversible posterior leukoencephalopathy syndrome, is a clinical ...
ObjectiveTo examine the association between a Mediterranean-style diet (MeDi) and brain magnetic resonance imaging white matter hyperintensity volume (WMHV).Des
It is often assumed that a parenchymal brain lesion which shows no contrast enhancement on magnetic resonance imaging(MRI) is a"low-grade tumor". We investigated a series of 20 patients with nonenhancing cerebral gliomas ; all underwent stereotactic biopsy or open resection, and histological diagnoses were astrocytoma(n=7), anaplastic astrocytoma(n=7), oligodendroglioma(n=5), and ganglioglioma(n=1). Before surgery, 11 patients underwent [18F] fluorodeoxyglucose positron emission tomography(FDG-PET), and this showed hypermetabolic features in two of four patients with anaplastic astrocytomas and in one of seven with astrocytomas or oligodendrogliomas. Among 17 patients, the mean Ki-67 labeling index was 4.4+/-4.3(range : 0.1-16.7), and the standard error was 1.04. These results indicate that in cerebral gliomas, the enhancing pattern seen on MRI cannot predict the degree of malignancy, and we suggest that even if ...
Posterior reversible encephalopathy syndrome (PRES) is a rare disease characterized by altered mental status, seizures, headache, vomiting and visual disturbances, most often described after transplantation and immunosuppressive therapy. PRES is commonly first diagnosed by the neuroradiologist, rather than the clinician, as it is characterized by very typical magnetic resonance imaging (MRI) features, i.e., hyperintense lesions in the territories of the posterior cerebral artery. Here we report our experience in the Intensive Care Unit (ICU) with a case of tacrolimus-related PRES after liver transplant, presenting with sudden neurological deterioration and diffuse and massive hyperintensities upon brain MRI. Discontinuation of tacrolimus, as prompted by the established literature, permitted the patient to eliminate tacrolimus-associated toxicity, whereas its substitution with everolimus and mycofenolic acid allowed the ...
An MRI scan is the best way to locate multiple sclerosis (MS) lesions (also called plaques) in the brain or spinal cord. An MRI scan is abnormal in more than 95% of people recently diagnosed with MS.footnote 1. But abnormal MRI results do not always mean that you have MS. Abnormalities show up on scans from many illnesses other than MS. An abnormal finding on an MRI scan alone is not enough to diagnose MS. Your doctor will confirm a diagnosis of MS based on your symptoms, your neurological exam, and the results from an MRI and other tests.. When abnormal MRI results occur along with a medical history, abnormal nervous system exam, and other test results that are typical of MS, it is very likely that you have MS.. If you have already been diagnosed with MS, MRI scans can sometimes distinguish new lesions from older ones and can help your doctor(s) follow the progress of the disease. Continuing to have periodic MRI scans if you have relapsing-remitting MS may help identify new lesions even ...
Regarding diagnosis with AAM, the characteristic MRI findings of AAM include the following: On T1-weighted MRI, it has low signal intensity. That is, it is of the same signal intensity as the skeletal muscle. On T2-weighted MRI, it has high signal intensity. These appearances likely relate to the loose myxoid matrix and high water content of angiomyxoma [11]. The CT findings demonstrated that the tumor, later identified as AAM, had a well-defined margin and an attenuation less than that of a muscle [11]. On ultrasonography, AAM appears as a hypoechoic or cystic mass [12]. In our case, the liver mass showed high signal intensity on T2-weighted MRI, as an attenuated mass on CT, and as a hypoechoic cystic region on ultrasound (Fig. 1). In our case, CT and FDG-PET unable to detect any mass in other regions including the pelvi-perineal region. Therefore, the AAM was concluded as of liver origin.. Immunohistochemically, AAM has been found to be positive for vimentin, desmin, CD 34, ER, PgR, and ...
TY - JOUR. T1 - Liver perfusion changes occurring during pancreatic islet engraftment. T2 - A dynamic contrast-enhanced magnetic resonance study. AU - Esposito, A.. AU - Palmisano, A.. AU - Maffi, P.. AU - Malosio, M. L.. AU - Nano, R.. AU - Canu, T.. AU - De Cobelli, F.. AU - Piemonti, L.. AU - Ironi, G.. AU - Secchi, A.. AU - Del Maschio, A.. PY - 2014/1. Y1 - 2014/1. N2 - The aim of this study was to investigate liver microvascular adaptation following the intraportal infusion of pancreatic islets (pancreatic islet transplantation [islet-tx]) in diabetic patients using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). DCE-MRI was performed before and 7 days after islet-tx in six diabetic patients. Initial area under curve (AUC60) and volume transfer coefficient (Ktrans) were assessed as markers of liver perfusion. Clinical and metabolic monthly follow-up was performed in all patients, ...
Value of Serial Multiparametric Magnetic Resonance Imaging and Magnetic Resonance Imaging-guided Biopsies in Men with Low-risk Prostate Cancer on Active Surveillance After 1 Yr Follow- ...
White matter hyperintensities also occurred often in all groups and differences between demented and non-demented patients largely resulted from variations in the severity and distribution of lesions. The pattern of WMHs in dementia with Lewy bodies was broadly similar to Alzheimers disease, but less extensive than vascular dementia. The prevalence of WMHs in vascular dementia and Alzheimers disease conformed well with previous studies, which have detected WMHs in up to 100% of patients with vascular dementia7 12 and between 60%-100% of patients with Alzheimers disease.2 The pathological correlates of WMHs in dementia with Lewy bodies have not yet been determined. The similar pattern of hyperintensities in dementia with Lewy bodies and Alzheimers disease suggests that they may share a convergence in white matter pathology. White matter lesions in Alzheimers disease have been linked to ischaemic changes46 but histological findings from other studies have identified various abnormalities, ...
The vertebroplasty versus conservative treatment in acute osteoporotic vertebral compression fractures (VERTOS and VERTOS II) trials are the only multicenter prospective randomized clinical trials comparing vertebroplasty with conservative medical management.. The original VERTOS trial was a small prospective multicenter randomized conservative management controlled study to assess the short-term outcome of patients with subacute osteoporotic vertebral compression fractures treated with vertebroplasty compared with conservative management.15 Inclusion criteria included debilitating back pain related to the fracture refractory to medical therapy for at least 6 weeks and no longer than 6 months, focal tenderness on physical examination at the affected level and MRI-documented marrow edema, defined as a decreased signal intensity on T1-weighted images and increased signal intensity on short tau inversion recovery (STIR) images. Thirty-four patients were enrolled with 18 patients randomized to ...
Spinal epidural abscess is a rare disorder with poor prognosis. In order to understand its clinical feature and method of treatment, a retrospective study of spinal epidural abscess spanning 8 years and encompassing 10 patients was done. There were 6 males and 4 females aged 12 to 64 years with peak incidence at the sixth decade. In one patient, epidural abscess recurred at the site previously treated 10 years ago. In addition to fever and leukocytosis in 8 patients, other frequent symptoms according to lesion site were abdominal pain and motor weakness in thoracic epidural abscess and low back pain and sciatica in lumbar epidural abscess. Staphylococcus aureus was the most common causative organism. Magnetic resonance imaging(MRI) showed variable signal on T1-weighted images and hyperintensity on T2-weighted images, which was studied in 6 patients. Two patterns in gadolinium-enhanced MRI were a central focus of low signal intensity ...
The highly interdisciplinary study of molecular magnetism spans a wide array of topics, ranging from spintronics and quantum computing to enzyme function and MRI contrast agents. At the core of all these fields is the study of materials whose properties can be controlled through the rational design of molecules. The chemical tailoring of molecular magnetic properties can only be achieved by understanding the relationship between the physical and electronic structures. In this dissertation, the interplay between structure and physical properties is probed using a variety of magnetic resonance techniques. In Chapter 1, we give a succinct overview of the various methods utilized in this dissertation. We first describe the experimental methods including electron paramagnetic resonance (EPR), 57Fe nuclear gamma resonance (Mössbauer) spectroscopy, electron double resonance detected nuclear ...
METHODS: Proton density and T2 weighted images were obtained on a 1.0 Tesla MRI scanner in patients with dementia with Lewy bodies (consensus criteria; n=27, mean age=75.9 years), Alzheimers disease (NINCDS/ADRDA; n=28, mean age=77.4 years), vascular dementia (NINDS/AIREN; n=25, mean age=76.8 years), and normal controls (n=26, mean age=76.2 years). Cognitive function, depressive symptoms, and psychotic features were assessed using a standardised protocol. Periventricular hyperintensities (PVHs), white matter hyperintensities (WMHs) and basal ganglia hyperintensities (BGHs) were visually rated blind to diagnosis using a semiquantitative scale ...
How is T1-weighted, gadolinium-enhanced magnetic resonance Imaging abbreviated? T1-MRI stands for T1-weighted, gadolinium-enhanced magnetic resonance Imaging. T1-MRI is defined as T1-weighted, gadolinium-enhanced magnetic resonance Imaging rarely.
A thin line of cortical low signal intensity ("motor dark line" or "hypointense rim") of the precentral gyrus on T2WI or FLAIR images has been advocated to be a marker of UMN compromise in ALS, particularly in advanced disease20,27. However, this T2 shortening effect results from excessive iron deposition, fibrillary gliosis, and/or macrophage infiltration, and such a change is neither sensitive nor specific to the pathology of UMN degeneration in ALS and can be found in healthy people, as well as in those with other degenerative diseases10,28-30.. Precentral gyrus subcortical hyperintensity on T2WI or FLAIR images has been reported as an important finding that represents CST abnormalities in UMN degeneration20,27,29. This hyperintensity is probably due to ALS-related degenerative changes and contributes to the diagnosis of ALS in some studies, although with a low sensitivity20,28,31. Central sulcus enlargement and CST hyperintensity on FLAIR images have demonstrated low sensitivity and ...
A core symptom of anxiety disorders is the tendency to interpret ambiguous information as threatening. Using electroencephalography and blood oxygenation level dependent magnetic resonance imaging (BOLD-MRI), several studies have begun to elucidate brain processes involved in fear-related perceptual biases, but thus far mainly found evidence for general hypervigilance in high fearful individuals. Recently, multi-voxel pattern analysis (MVPA) has become popular for decoding cognitive states from distributed patterns of neural activation. Here, we used this technique to assess whether biased fear generalization, characteristic of clinical fear, is already present during the initial perception and categorization of a stimulus, or emerges during the subsequent interpretation of a stimulus. Individuals with low spider fear (n = 20) and high spider fear (n = 18) underwent functional MRI scanning while viewing ...
Diabetes mellitus is associated with an increase in proliferative lesions in the small cerebral vessels.1 Functionally, the blood-retinal barrier is closely related to the blood-brain barrier (BBB)2 and cortical capillaries in experimental models of diabetes exhibit similar microangiopathy to that found in the human retina in diabetes.3, 4. A principal neuroradiological feature that may be associated with cerebral microvascular disease is "white matter hyperintensities" or "leukoaraiosis", a mixed condition of uncertain aetiology manifested on CT scans as hypodensity in the cerebral white matter, and as hyperintensities on T2, proton density or fluid attenuated inversion recovery (FLAIR) MR imaging.5 Recent longitudinal studies have highlighted diabetes as a risk factor for dementia, doubling the risk of senile dementia of the Alzheimer type.6 Several studies have established a correlation between the presence and extent of white matter ...
Fig 1. Acute osteopenic compression fracture of the L1 vertebral body simulating metastasis. The mean ADC value of the lesion is 2.8 × 10−4 mm2/s.. A, Sagittal T1-weighted MR image (600/8; section thickness, 5 mm; intersection spacing, 1 mm; FOV, 32 cm; matrix, 512 × 512) shows the lesion as diffusely hypointense (arrow). Typical appearance of benign compression fracture involves the T12 vertebral body, with a bandlike area of abnormal signal intensity (arrowhead).. B, Sagittal T2-weighted fat-suppressed MR image (3000/99; section thickness, 5 mm; intersection spacing, 1 mm; FOV, 32 cm) shows the lesion as hyperintense (arrow). Typical appearance of benign compression fracture involves the T12 vertebral body, with a bandlike area of abnormal signal intensity (arrowhead).. C, Sagittal contrast-enhanced T1-weighted fat-suppressed MR image (416/8.3; section thickness, 5 mm; intersection spacing, 1 mm; FOV, 32 cm) shows the lesion as enhanced (arrow). Typical appearance of benign compression ...
A 41-year-old man with a previous kidney transplant was referred for arterial hypertension and acute renal failure. Initial neurological examination was normal. Laboratory data showed a high serum cyclosporine A concentration. A few hours later, he developed generalised tonic-clonic seizures. The brain computed tomogram was not remarkable, but Glasgow Coma Scale score remained at 8. Mechanical ventilation was required for rapidly progressive hypoxaemia related to Staphylococcus aureus pneumonia and septicaemia. Noradrenaline infusion was needed for only nine hours, with no major drop in mean arterial blood pressure. On day three his Glasgow Coma Scale score was 3/15, with fixed dilated pupils. The brain computed tomogram revealed bilateral hypodense lesions in the posterior areas together with cerebral oedema and the patient was subsequently declared brain dead. We discuss the possibility of a posterior reversible encephalopathy syndrome, likely triggered by ...
The anterior cingulate cortex has cognitive and affective divisions that are separable both anatomically and functionally.2 Previous studies in healthy individuals have shown that the affective division of the anterior cingulate cortex is activated by a number of emotional manipulations2,23 and our data in healthy participants confirm the findings of Whalen et al,4 who used an emotional counting Stroop to demonstrate increased activation in the pregenual region of the affective subdivision of the anterior cingulate cortex in response to emotional relative to neutral words. Also, in agreement with Whalen et al, we found that the emotional counting Stroop task was associated with an overall deactivation in this subdivision compared with fixation but that the deactivation was relatively less during presentation of emotional words. It has been suggested that the overall deactivation of the affective subdivision of the anterior cingulate cortex in response to the emotional counting Stroop ...
Spinal cord infarction (SCI) is a rare type of stroke. The initial magnetic resonance imaging (MRI) is usually normal and can mimic the presentation of the acute transverse myelitis (ATM), acute inflammatory demyelinating polyneuropathy, and compressive myelopathies from neoplasm, epidural or subdural hematoma, or abscess. The aim of this report is to describe and discuss the case of a patient with SCI presenting as a diagnostic confusion with acute transverse myelitis. A 64-year-old male with a medical history of hypertension presented with an acute onset of urinary retention with lower limb weakness. Based on the initial MRI and evaluation, a diagnosis of acute transverse myelitis was made. Despite thorough evaluation, the etiology of transverse myelitis was undetermined. Hence, the MRI of the thoracic spine was repeated which showed patchier enhancements of the vertebral body with features suggestive of the spinal cord and vertebral body ...
Investigators from Soochow University, Suzhou, China, studied the possible pathogenetic mechanisms and treatment of posterior reversible encephalopathy syndrome (PRES) observed in 11 cases of pediatric acute lymphoblastic leukemia (ALL) after induction chemotherapy. The clinical symptoms of PRES disappeared after appropriate treatment in most cases, even though induction chemotherapy continued. During the 1-year follow-up, no recurrence of PRES was observed. PRES should be recognized as an important complication of ALL that is reversible when diagnosed and treated early. Of the 11 children, 7 were boys and 4 girls. They were reviewed at an average age of 8.5 years (range, 5-14 years old). During the ALL inductive treatment (VDLD), 4 patients (36%) had an increase in blood pressure. Intrathecal chemotherapy included methotrexate, cytosine arabinoside, and dexamethasone. During the chemotherapy period (days 7 to 30) patients developed acute brain dysfunction, manifested by headache (10/11), ...
1. Moran C, Phan TG, Srikanth VK. Cerebral small vessel disease: A review of clinical, radiological, and histopathological phenotypes. International Journal of Stroke. 2012;7:36-46 2. Pantoni L. Cerebral small vessel disease: From pathogenesis and clinical characteristics to therapeutic challenges. Lancet Neurol. 2010;9:689-701 3. Xiong YY, Mok V. Age-related white matter changes. Journal of Aging Research. 2011;2011:1-13 4. Xiong Y, Mok V, Wong A, Chen X, Chu WC, Fan Y, Soo Y, Wong KS. The age-related white matter changes scale correlates with cognitive impairment. Eur J Neurol. 2010;17:1451-1456 5. Debette S, Markus HS. The clinical importance of white matter hyperintensities on brain magnetic resonance imaging: Systematic review and meta-analysis. Bmj. 2010;341:c3666 6. de Groot JC, de Leeuw FE, Oudkerk M, Hofman A, Jolles J, Breteler MM. Cerebral white matter lesions and subjective cognitive dysfunction: The rotterdam ...
Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state that occurs secondary to the inability of the posterior circulation to autoregulate in response to acute changes in blood pressure. Hyperperfusion with resultant disruption...
Free Online Library: Recurring posterior reversible encephalopathy syndrome in a patient with polymyositis/systemic sclerosis overlap syndrome triggered by scleroderma renal crisis.(Case Report) by European Journal of Rheumatology; Health, general Encephalopathy Care and treatment Immunotherapy Patient compliance Scleroderma (Disease) Systemic scleroderma
RESULTS. There were 27 patients (14 male, 13 female) with a mean age of 62 (range, 44-77) years. There were 10 patients with renal transplants; their native renal arteries were not evaluated. Each of the two experienced interventional and body magnetic resonance radiologists, who were blinded to the results, reviewed the digital subtraction angiography and magnetic resonance angiography images respectively. Digital subtraction angiography was used as the standard of reference. A total of 39 renal arteries from these 27 patients were evaluated. One of the arteries was previously stented and could not be assessed with magnetic resonance angiography due to severe artefacts. Of the remaining 38 renal arteries, two were graded as normal, seven as having mild stenosis (=50% but =75%). Magnetic resonance angiography and digital subtraction angiography were concordant in 89% of the ...
This study reviews the literature on the anatomy of the connective tissues surrounding the distal interphalangeal joint and further characterizes the three-dimensional relationships of these structures with ultra-high field magnetic resonance imaging. Ten cadaver fingers, fixed in a solution of 5% agar and 4% formalin, were imaged utilising an ultrashield 16.4 Tesla ultra-high field magnetic resonance imaging, yielding a total of 4000 images. Images were analysed using Osirix™ (version 5.5.1 32 bit edition) for three-dimensional reconstruction. We found numerous conflicting descriptions of the connective tissue structures around the distal interphalangeal joint. Based upon our literature review and imaging studies we have defined precisely Clelands ligaments, the oblique proximal septum, Graysons ligaments, the dorsal plate, and the ...
In the human this area is known as ventral anterior cingulate area 24, and it refers to a subdivision of the cytoarchitecturally defined cingulate region of cerebral cortex (area cingularis anterior ventralis). It occupies most of the anterior cingulate gyrus in an arc around the genu of corpus callosum. Its outer border corresponds approximately to the cingulate sulcus. Cytoarchitecturally it is bounded internally by the pregenual area 33, externally by the dorsal anterior cingulate area 32, and caudally by the ventral posterior cingulate area 23 and the dorsal posterior cingulate area 31. Francis Crick, one of the discoverers of DNA, listed area 24 as the seat of free will because of its centrality in abulia and amotivational syndromes. ...
In the absence of external stimuli or task demands, correlations in spontaneous brain activity (functional connectivity) reflect patterns of anatomical connectivity. Hence, resting-state functional connectivity has been used as a proxy measure for structural connectivity and as a biomarker for brain changes in disease. To relate changes in functional connectivity to physiological changes in the brain, it is important to understand how correlations in functional connectivity depend on the physical integrity of brain tissue. The causal nature of this relationship has been called into question by patient data suggesting that decreased structural connectivity does not necessarily lead to decreased functional connectivity. Here we provide evidence for a causal but complex relationship between structural connectivity and functional connectivity: ...
The "Intraoperative Magnetic Resonance Imaging (MRI) Sales Market" report offers a thorough examination of the diverse patterns and factors affecting the development direction of the worldwide market. An evaluation of the effect of government guidelines and approaches available tasks is likewise included to give an all-encompassing outline of the Intraoperative Magnetic Resonance Imaging (MRI) Sales markets future viewpoint. It incorporates into profundity data relating to the common elements of the market and displays refined development gauges for the market dependent on solid information. The Intraoperative Magnetic Resonance Imaging (MRI) Sales advertise report investigates the market based on its real geologies, showcase sections, and current market patterns. The report has data of worldwide ...
TY - JOUR. T1 - A Case of Ecchordosis Physaliphora in the Prepontine Cistern. T2 - A Rare Entity in the Differential Diagnosis of an Epidermoid Cyst. AU - Miki, Kenji. AU - Yoshimoto, Koji. AU - Nishimura, Ataru. AU - Suzuki, Satoshi O.. AU - Hiwatashi, Akio. AU - Iihara, Koji. PY - 2017/9. Y1 - 2017/9. N2 - Background Ecchordosis physaliphora (EP) is a benign notochordal remnant that is usually asymptomatic. We report a case of a symptomatic large EP mimicking an epidermoid cyst. Case Description A 44-year-old woman presented with right facial dysesthesia. Brain magnetic resonance imaging showed a mass with a diameter of 3.2 cm that was hypointense on T1-weighted imaging, hyperintense on T2-weighted imaging, isointense to hyperintense on diffusion-weighted imaging, and hyperintense on apparent diffusion coefficient map ...
Neuronal underpinnings of auditory verbal hallucination remain poorly understood. One suggested mechanism is brain activation that is similar to verbal imagery but occurs without the proper activation of the neuronal systems that are required to tag the origins of verbal imagery in ones mind. Such neuronal systems involve the supplementary motor area. The supplementary motor area has been associated with awareness of intention to make a hand movement, but whether this region is related to the sense of ownership of ones verbal thought remains poorly known. We hypothesized that the supplementary motor area is related to the distinction between ones own mental processing (auditory verbal imagery) and similar processing that is attributed to non-self author (auditory verbal hallucination). To test this hypothesis, we asked patients to signal the onset and offset of their auditory verbal hallucinations during functional magnetic resonance ...
Introduction: Spinal Subdural hematoma is a rare cause of radiculopathy and spinal cord compression syndromes. Its early diagnosis is essential. Chronological appearance of these bleeds vary on MRI. Case Report: A 56 year old man presented with progressive left lower limb radiculopathy and paraesthesias with claudication of three days duration. MRI revealed a subdural space occupying lesion compressing the cauda equina at L5-S1 level producing a Y shaped dural sac (Y sign), which was hyperintense on T1W imaging and hypointense to cord on T2W image. The STIR sequence showed hyperintensity to cord. There was no history of bleeding diathesis. The patient underwent decompressive durotomy and biopsy which confirmed the diagnosis. Conclusion: Spinal subdural hematoma may present with rapidly progressive neurological symptoms. MRI is the investigation of choice. The knowledge of MRI appearance with respect to the chronological stage of the bleed is essential to avoid diagnostic and ...
TY - JOUR. T1 - Longitudinal optical coherence tomography study of optic atrophy in secondary progressive multiple sclerosis. T2 - Results from a clinical trial cohort. AU - Winges, Kimberly. AU - Murchison, Charles F.. AU - Bourdette, Dennis. AU - Spain, Rebecca. PY - 2017/11/1. Y1 - 2017/11/1. N2 - Background: Limited prospective information exists regarding spectral-domain optical coherence tomography (SD-OCT) in secondary progressive multiple sclerosis (SPMS). Objective: Document cross-sectional and longitudinal retinal nerve fiber layer (RNFL) and macular ganglion cell plus inner plexiform layer (GCIPL) features of an SPMS clinical trial cohort. Methods: Prospective, observational study using a 2-year randomized placebo-controlled SPMS trial cohort with yearly SD-OCT testing. Post hoc analysis determined influences of optic neuritis (ON), disease duration, and baseline SD-OCT on annualized atrophy rates and on correlations between OCT and brain atrophy. Results: Mean RNFL and GCIPL ...
article{758a50e9-9c82-4c95-9cff-accfd994939d, abstract = {Objective: To discuss terminology, radiological differential diagnoses and significance of magnetic resonance imaging (MRI)-detected subchondral bone marrow lesions (BMLs) of the knee joint. Methods: An overview of the published literature is presented. In addition, the radiological appearance and differential diagnosis of subchondral signal alterations of the knee joint are discussed based on expert consensus. A recommendation for terminology is provided and the relevance of these imaging findings for osteoarthritis (OA) research is emphasized. Results: A multitude of differential diagnoses of subchondral BMLs may present with a similar aspect and signal characteristics. For this reason it is crucial to clearly and specifically define the type of BML that is being assessed and to use terminology that is appropriate to the condition and the pathology. ...
en] OBJECTIVES: The aim of this study was to investigate the relationship between medial cortical activation and the presence of self and consciousness in healthy subjects and patients with vegetative state and minimally conscious state using functional magnetic resonance imaging (fMRI). EXPERIMENT DESIGN: We first conducted two fMRI experiments in healthy subjects to identify brain regions specifically associated with self-perception through the use of different auditory stimuli that had different grades of self-relatedness. We then applied these regions as functional localizers to examine the relationship between neural activity changes during self-relatedness and consciousness level in the patients with disorders of consciousness (DOC). PRINCIPAL OBSERVATIONS: We demonstrated recruitment of various anterior medial cortical regions including the anterior cingulate cortex (ACC) in healthy ...
To our knowledge, few reports on the imaging of oncocytic neoplasms of the salivary glands have been published, owing to the rarity of the condition. Sakai et al1 reported an oncocytoma in the deep lobe of the parotid gland that was well-defined and solid on CT. It demonstrated decreased signal intensity on both T1- and T2-weighted MR images, attributed to the high cellularity and low free water content. According to the authors, Warthin tumor, which is a common benign parotid gland tumor in patients older than 60 years, can be differentiated from oncocytoma by its MR imaging appearance. Warthin tumors conversely demonstrate decreased signal intensity on T1-weighted images and increased signal intensity on T2-weighted images.1 Both Warthin tumors and oncocytomas show intense uptake of the nuclide on technetium-Tc99m pertechnetate radionuclide scans of the salivary glands.2. The histomorphologic findings of oncocytes include an enlarged ...
TY - JOUR. T1 - Interferon-α acutely impairs whole-brain functional connectivity network architecture - A preliminary study. AU - Dipasquale, Ottavia. AU - Cooper, Ella A. AU - Tibble, Jeremy. AU - Voon, Valerie. AU - Baglio, Francesca. AU - Baselli, Giuseppe. AU - Cercignani, Mara. AU - Harrison, Neil A.. N1 - Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.. PY - 2016/11. Y1 - 2016/11. N2 - Interferon-alpha (IFN-α) is a key mediator of antiviral immune responses used to treat Hepatitis C infection. Though clinically effective, IFN-α rapidly impairs mood, motivation and cognition, effects that can appear indistinguishable from major depression and provide powerful empirical support for the inflammation theory of depression. Though inflammation has been shown to modulate activity within discrete brain regions, how it affects distributed information processing and the architecture of whole brain ...
The purposes of radiologic evaluation for patients suspected of having ATM are to differentiate other spinal cord lesions, and to investigate the cause of ATM [1,2]. The diagnostic criteria by TMCWG recommends spinal MRI evaluation with gadolinium enhancement to facilitate early identification of ATM and to determine the cause [7]. However, because there were cases that showed normal findings on spinal MRI, "possible ATM" cases should be reevaluated later with spinal MRI [5,7]. According to previous studies, 53% of ATM cases showed normal findings on spinal MRI, and 19% to 42.1% showed no gadolinium enhancement on spinal MRI [5,16]. In the present study, 65.2% of the subjects showed high signal intensity of T2-weighted images, and 43.3% of subjects showed gadolinium enhancement on spinal MRI. Lesions at the thoracic spinal cord level are the most common spinal lesions found by MRI [4,15]. However, Kaplin et al. [14] and De Seze et al. [16] reported cervical spinal cord lesions in 44% and 37% of ...
TY - JOUR. T1 - Augmented reality for improving catheterization in magnetic resonance imaging-guided cardiac electrophysiology therapy. AU - Chen, Yue. AU - Kwok, Ka Wai. AU - Ge, Jia. AU - Hu, Yang. AU - Fok, Mable. AU - Nilsson, Kent R. AU - Tse, Zion Tsz Ho. PY - 2014/1/1. Y1 - 2014/1/1. UR - http://www.scopus.com/inward/record.url?scp=84938237749&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=84938237749&partnerID=8YFLogxK. U2 - 10.1115/1.4027017. DO - 10.1115/1.4027017. M3 - Article. AN - SCOPUS:84938237749. VL - 8. JO - Journal of Medical Devices, Transactions of the ASME. JF - Journal of Medical Devices, Transactions of the ASME. SN - 1932-6181. IS - 2. M1 - 020917. ER - ...
TY - JOUR. T1 - Pyogenic liver abscess. T2 - Contrast-enhanced MR imaging in rats. AU - Weissleder, R.. AU - Saini, S.. AU - Stark, D. D.. AU - Elizondo, G.. AU - Compton, C.. AU - Wittenberg, J.. AU - Ferrucci, J. T.. PY - 1987. Y1 - 1987. N2 - MR imaging was used to evaluate experimentally induced pyogenic liver abscesses in an animal model. Rats were examined before and after IV administration of either gadolinium-diethylenetriaminepentaacetic acid (Gd-DTPA), ferrite particles, or both contrast agents together. Pyogenic liver abscesses appeared hypointense on T1-weighted images and hyperintense on T2-weighted images. Bolus administration of Gd-DTPA using a fast spin-echo sequence with repetition time of 250 msec and echo time of 20 msec (SE 250/20) showed transient selective enhancement of normal hepatic tissue and increased lesion conspicuity, quantitatively assessed by the contrast-to-noise ratio, which increased from -35.7 to -59.0. ...
TY - GEN. T1 - Segmentation and classification of breast tumor using dynamic contrast-enhanced MR images. AU - Zheng, Yuanjie. AU - Baloch, Sajjad. AU - Englander, Sarah. AU - Schnall, Mitchell D.. AU - Shen, Dinggang. PY - 2007/12/1. Y1 - 2007/12/1. N2 - Accuracy of automatic cancer diagnosis is largely determined by two factors, namely, the precision of tumor segmentation, and the suitability of extracted features for discrimination between malignancy and benignancy. In this paper, we propose a new framework for accurate characterization of tumors in contrast enhanced MR images. First, a new graph cut based segmentation algorithm is developed for refining coarse manual segmentation, which allows precise identification of tumor regions. Second, by considering serial contrast-enhanced images as a single spatio-temporal image, a spatio-temporal model of segmented tumor is constructed to extract Spatio-Temporal Enhancement Patterns (STEPs). STEPs are designed to capture not only dynamic ...
In the somatosensory system, it is well known that the bilateral secondary somatosensory cortex (SII) receives projections from the unilateral primary somatosensory cortex (SI), and the SII cortex, in turn, sends feedback projections to SI. Most neuroimaging studies have clearly shown bilateral SII activation using only unilateral stimulation for both anatomical and functional connectivity across SII subregions. However, no study has unveiled differences in the functional connectivity of the contra- and ipsilateral SII network that relate to frontoparietal areas during tactile object recognition. Therefore, we used event-related functional magnetic resonance imaging (fMRI) and a delayed match-to-sample (DMS) task to investigate the contributions of bilateral SII during tactile object recognition. In the fMRI experiment, fourteen healthy subjects were ...
Cerebral small vessel disease is considered hereditary in about 5% of patients and is characterized by lacunar infarcts and white matter hyperintensities on MRI. Several monogenic hereditary diseases causing cerebral small vessel disease and stroke have been identified. The purpose of this systematic review is to provide a guide for determining when to consider molecular genetic testing in patients presenting with small vessel disease and stroke. CADASIL, CARASIL, collagen type IV mutations (including PADMAL), retinal vasculopathy with cerebral leukodystrophy, Fabry disease, hereditary cerebral hemorrhage with amyloidosis, and forkhead box C1 mutations are described in terms of genetics, pathology, clinical manifestation, imaging, and diagnosis. These monogenic disorders are often characterized by early-age stroke, but also by migraine, mood disturbances, vascular dementia and often gait disturbances. Some also present with extra-cerebral manifestations such as ...
In our event-related functional magnetic resonance imaging (fMRI) experiment, participants learned to select between two response options by trial-and-error, using feedback stimuli that indicated monetary gains and losses. The results of the experiment indicate that error responses and error feedback activate the same region of dorsal anterior cingulate cortex, suggesting that this region is sensitive to both internal and external sources of error information.
MRI (Magnetic Resonance Imaging) White Plains - MRI (Magnetic Resonance Imaging), Magnetic Resonance Angiography (MRA), Magnetic Resonance Venography (MRV) and other services which are offered at Hartsdale Imaging serving White Plains, Yonkers and the surrounding area.
Pretreatment dynamic contrast-enhanced MRI biomarkers correlate with progression-free survival in primary central nervous system lymphoma Academic Article ...
TY - JOUR. T1 - Spontaneous spinal epidural hematoma in children. AU - Patel, Hema. AU - Boaz, Joel C.. AU - Phillips, John P.. AU - Garg, Bhuwan P.. PY - 1998/10/1. Y1 - 1998/10/1. N2 - Spontaneous spinal epidural hematoma is rare in children. It is usually confined to the dorsal epidural space. Ventral spontaneous spinal epidural hematoma (SSEH) is rarer, with only two previous reports. The authors present three children, two with dorsal and one with ventral spinal epidural hematoma, and review the literature. No etiology of the hematoma was found in the authors patients and there was no history of trauma. A review of 24 patients of children younger than 18 years of age reported in the literature and the authors three patients revealed that the cervicothoracic region was the most common site of SSEH, the mode of onset was frequently subacute, and there was no male preponderance as has been reported in adults. We found that the initial symptoms were often nonspecific, leading to a delay in ...
Title:Basal Ganglia Enlarged Perivascular Spaces are Linked to Cognitive Function in Patients with Cerebral Small Vessel Disease. VOLUME: 11 ISSUE: 2. Author(s):Marjolein Huijts, Annelien Duits, Julie Staals, Abraham A Kroon, Peter W de Leeuw and Robert J van Oostenbrugge. Affiliation:Department of Neurology, Maastricht University Medical Centre, PO Box 5800, 6202 AZ Maastricht , The Netherlands.. Keywords:Cerebral small vessel disease, cognition, enlarged perivascular spaces, hypertension, lacunar stroke, white matter lesions.. Abstract:Enlarged perivascular spaces (EPVS) are a feature of cerebral small vessel disease (cSVD) and have been related to cSVD severity. A higher number of EPVS were related to decreased cognition in healthy elderly, but this has never been investigated in patients at high risk of cSVD. We included 189 patients with a high risk of cSVD (hypertensive patients and lacunar stroke patients). Patients underwent brain MRI and extensive neuropsychological assessment. EPVS ...
PRES is extremely rare, and usually diagnosed by a history of sudden visual impairment in the presence of specific radiological changes on MRI. Bilateral symmetrical hypodensitities in the parieto-occipital areas and cerebellar hemispheres on imaging are characteristic. The condition has been associated with chemotherapy, hypertension, infection and autoimmune disease.1. It is thought to occur from temporary impairment of the blood brain barrier causing vasogenic edema with symptoms of reduced consciousness, seizures, headaches, and typically visual problems.2 Around 26-67% of patients with PRES present with visual symptoms of blurred vision, visual neglect, homonymous hemianopsia, hallucinations or cortical blindness.. Our case is unusual, as PRES caused by pancreatitis has only been reported in very sick patients with other comorbidities. It probably occurred in this case as a result of the systemic inflammatory response.3,4,5,6. Whilst pancreatitis itself ...
Mesial versus lateral. Temporal lobe epilepsy is the most common seizure disorder in adults. While mesial temporal lobe epilepsy can be associated with olfactory hallucinations, deja vu and epigastric auras, temporal lobe seizures arising from the lateral cortex rather than the hippocampus may present with auditory hallucinations as the initial seizure symptoms. While the genetics of mesial temporal lobe epilepsy remains poorly understood, the genetics of the far less common lateral temporal lobe epilepsies had major breakthrough when mutations in LGI1 were discovered in familial cases. LGI1, a secreted presynaptic protein, has mystified the field for over a decade, given that we have problems understanding how a highly localized form of epilepsy can be caused by a global genetic defect. In their recent study in AJHG, Dazzo and collaborators add another confusing piece to the puzzle. They identify RELN (reelin) mutations in families with autosomal dominant lateral temporal lobe epilepsy ...
Looking for online definition of Progressive nonfluent aphasia in the Medical Dictionary? Progressive nonfluent aphasia explanation free. What is Progressive nonfluent aphasia? Meaning of Progressive nonfluent aphasia medical term. What does Progressive nonfluent aphasia mean?
OBJECTIVE: The goal of this study was 2-fold, first, to compare decision making in behavioral variant frontotemporal dementia (bvFTD) patients and healthy adults using the Balloon Analog Risk Task (BART), and, second, to identify the regions of gray matter atrophy associated with bvFTD patients BART performance. BACKGROUND: Stimulus-reinforcement learning is required to evaluate the results of previously chosen actions to improve future decisions. Although there is a well established literature suggesting altered decision making in FTD patients and data from lesion studies suggest orbitofrontal cortex (OFC) involvement in decision making, there is very little research looking at the brain correlates of decision making in FTD populations specifically. METHOD: Twenty-seven bvFTD patients and 19 age-matched and education-matched normal controls completed the BART. Voxel-based morphometry analysis was performed on the magnetic resonance ...
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by infantile hypotonia, hyperphagia, hypogonadism, growth hormone deficiency, intellectual disability, and severe emotional and behavioral problems. The brain mechanisms that underpin these disturbances are unknown. Diffusion tensor imaging (DTI) enables in vivo investigation of the microstructural integrity of white matter pathways. To date, only one study has used DTI to examine white matter alterations in PWS. However, that study used selected regions of interest, rather than a whole brain analysis. In the present study, we used diffusion tensor and magnetic resonance (T 1-weighted) imaging to examine microstructural white matter changes in 15 individuals with PWS (17-30 years) and 15 age-and-gender-matched controls. Whole-brain voxel-wise statistical analysis of FA was carried out using ...
High resolution diffusion tensor images of the mouse brain were acquired using the pulsed gradient spin echo sequence and the oscillating gradient spin echo sequence. The oscillating gradient spin echo tensor images demonstrated frequency-dependent changes in diffusion measurements, including apparent diffusion coefficient and fractional anisotropy, in major brain structures. Maps of the rate of change in apparent diffusion coefficient with oscillating gradient frequency revealed novel tissue contrast in the mouse hippocampus, cerebellum, and cerebral cortex. The observed frequency-dependent contrasts resembled neuronal soma-specific Nissl staining and nuclei-specific 4,6-diamidino-2-phenylindole (DAPI) staining in the mouse brain, which suggests that the contrasts might be related to key features of cytoarchitecture in the brain. In the mouse cuprizone model, oscillating gradient spin echo-based diffusion MRI revealed significantly higher ...
Objective: To characterize and quantify the patterns of temporal lobe atrophy in AD vs semantic dementia and to relate the findings to the cognitive profiles. Medial temporal lobe atrophy is well described in AD. In temporal variant frontotemporal dementia (semantic dementia), clinical studies suggest polar and inferolateral temporal atrophy with hippocampal sparing, but quantification is largely lacking. Methods: A volumetric method for quantifying multiple temporal structures was applied to 26 patients with probable AD, 18 patients with semantic dementia, and 21 matched control subjects. Results: The authors confirmed the expected bilateral hippocampal atrophy in AD relative to controls, with involvement of the amygdala bilaterally and the right parahippocampal gyrus. Contrary to expectations, patients with semantic dementia had asymmetric hippocampal atrophy, more extensive than AD on the left. As predicted, the semantic dementia group showed more severe involvement of the temporal pole ...
TY - JOUR. T1 - Measuring tumor perfusion in control and treated murine tumors. T2 - Correlation of microbubble contrast-enhanced sonography to dynamic contrast-enhanced magnetic resonance imaging and fluorodeoxyglucose positron emission tomography. AU - Niermann, Kenneth J.. AU - Fleischer, Arthur C.. AU - Huamani, Jessica. AU - Yankeelov, Thomas E.. AU - Kim, Dong W.. AU - Wilson, Wendy D.. AU - Hallahan, Dennis E.. PY - 2007/6. Y1 - 2007/6. N2 - Objective. The purpose of this study was to evaluate the ability of dynamic microbubble contrast-enhanced sonography (MCES), in comparison with dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and fluorodeoxyglucose positron emission tomography (FDG-PET), to quantitatively characterize tumor perfusion in implanted murine tumors before and after treatment with a variety of regimens. Methods. Seventeen mice with Lewis ...
Compared with previous 1H MRI approaches for visualizing the infiltration of immunocompetent cells into inflamed areas by use of superparamagnetic iron oxide particles, the method presented here has the advantage of a direct positive detection of the tagging agent and therefore has the potential to work also in tissues that generally appear very dark in 1H MRI such as the lungs. Although techniques have recently been described to image superparamagnetic iron oxide particles with a bright contrast,18 the physical basis of detection is still the disturbance of the regional magnetic field by these particles. Therefore, it often remains difficult to unequivocally assign alterations in local contrast to accumulating superparamagnetic iron oxide particles. Furthermore, iron-based contrast agents are readily metabolized, whereas the fluorinated crown ether used in this study is biologically inert and cannot easily be degraded. The reason is the ...
The protective effect of education has been well established in Alzheimers disease, whereas its role in patients with isolated cerebrovascular diseases remains unclear. We examined the correlation of education with cortical thickness and cerebral small vessel disease markers in patients with pure subcortical vascular mild cognitive impairment (svMCI) and patients with pure subcortical vascular dementia (SVaD). We analyzed 45 patients with svMCI and 47 patients with SVaD with negative results on Pittsburgh compound B positron emission tomographic imaging who underwent structural brain magnetic resonance imaging. The main outcome was cortical thickness measured using surface-based morphometric analysis. We also assessed the volumes of white matter hyperintensities (WMH) and numbers of lacunes as other outcomes. To investigate the correlation of education with cortical thickness, WMH volume, ...
Diffusion imaging of post-mortem brains could provide valuable data for validation of diffusion tractography of white matter pathways. Long scans (e.g., overnight) may also enable high-resolution diffusion images for visualization of fine structures. However, alterations to post-mortem tissue (T2 and diffusion coefficient) present significant challenges to diffusion imaging with conventional diffusion-weighted spin echo (DW-SE) acquisitions, particularly for imaging human brains on clinical scanners. Diffusion-weighted steady-state free precession (DW-SSFP) has been proposed as an alternative acquisition technique to ameliorate this tradeoff in large-bore clinical scanners. In this study, both DWSE and DW-SSFP are optimized for use in fixed white matter on a clinical 3-Tesla scanner. Signal calculations predict superior performance from DW-SSFP across a broad range of ...
ABSTRACT. Aging often results in reduced visual acuity from changes in both the eye and neural circuits [1-4]. In normally aging subjects, primary visual cortex has been shown to have reduced responses to visual stimulation [5]. It is not known, however, to what extent aging affects visual field representations and population receptive sizes in human primary visual cortex. Here we use functional MRI (fMRI) and population receptive field (pRF) modeling [6] to measure angular and eccentric retinotopic representations and population receptive fields in primary visual cortex in healthy aging subjects ages 57 - 70 and in healthy young volunteers ages 24 - 36 (n = 9). Retinotopic stimuli consisted of black and white, drifting checkerboards comprising moving bars 11 deg in radius. Primary visual cortex (V1) was clearly identifiable along the calcarine sulcus in all hemispheres. There was a significant decrease in the surface area of V1 from 0 to 3 deg eccentricity in the aging subjects with respect ...
Purpose To determine whether a single 51-minute exposure to acoustic noise during 3-T multisequence magnetic resonance (MR) neuroimaging could affect the hearing threshold of healthy adults with earplugs and sponge mats as hearing protection. Materials and Methods With earplugs and motion-refraining sponge mats as hearing protection, 26 healthy young adults underwent 3-T MR neuroimaging imaging that included T1-weighted three-dimensional gradient-echo sequence, T2-weighted fast spin-echo sequence, diffusion-tensor imaging, diffusion-kurtosis imaging, T2*-weighted three-dimensional multiecho gradient-echo sequence, and blood oxygen level-dependent imaging. Automated auditory brainstem response (ABR) was used to measure the hearing thresholds within 24 hours ...
BACKGROUND: Reduction in gadolinium (Gd) contrast agents is wanted due to the uncertainty of the potential side effects.. PURPOSE: To investigate whether it is possible to reduce the contrast dose from conventional double dose to single dose when increasing the field strength from 1.5-T to 3-T for separating early cartilage degeneration from healthy cartilage, assessed by delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC).. MATERIAL AND METHODS: Nine patients with knee osteoarthritis (OA), Kellgren-Lawrence grade (KLG) 1-4, were recruited from an ongoing weight loss cohort study. dGEMRIC was performed at 3-T using single (0.1 mmoI/kg) and double (0.2 mmoI/kg) doses of intravenous (i.v.) Gd-DTPA2-. Regions of interest (ROls) were drawn around the posterior weight-bearing femoral knee cartilage in lateral and medial compartments. In five medial compartments ROIs could not be drawn due to severe degeneration of ...
On MR imaging, the white matter lesions, which could be seen in the subacute stage, but not in the acute or chronic stage, might represent edema due to postinfectious neuroallergic phenomena. Immunohistochemical detection of HSV antigen is depicted in B. The sparse amount of literature on proton magnetic resonance spectroscopy in patients with herpes simplex type 1 encephalitis is discussed. Here is MRI Brain with single voxel MRI Spectroscopy. MR spectra of bilateral temporal lobes were acquired by the single voxel method using 1.5T unit. We performed MR imaging and 1H MR spectroscopy of the brain in patients with different types of primary mitochondrial diseases to investigate the role of 1H MR spectroscopy in the clinical evaluation of these disorders. Theyre usually red in colour and will develop a white head.. Although the clinical picture has been well established for ...
Assessing the pathology of the synovium, its thickening and increased vascularity through ultrasound and magnetic resonance examinations (more often an ultrasound study alone) is still considered a sensitive parameter in the diagnosis of rheumatoid arthritis and in monitoring of treatment efficacy. Magnetic resonance studies showed that, aside from the joint pannus, the subchondral bone tissue constitutes an essential element in the development of rheumatoid arthritis. Bone marrow edema correlates with inflammation severity, joint destruction, clinical signs and symptoms of rheumatoid arthritis, and thus is considered a predictor of rapid radiological progression of the disease. The newest studies reveal that bone marrow edema may be a more sensitive indicator of the response to therapy than appearance of the synovium. Bone marrow edema presents with increased signal in T2-weighted images, being most visible in fat saturation or IR sequences ...
The journal focuses on neuroimmunology and neuroinflammation, and the coverage extends to other basic and clinical studies related to neuroscience including molecular biology, psychology, pathology, physiology, endocrinology, pharmacology, oncology, etc.
Aging often results in reduced visual acuity from changes in both the eye and neural circuits [1-4]. In normally aging subjects, primary visual cortex has been shown to have reduced responses to visual stimulation [5]. It is not known, however, to what extent aging affects visual field repre-sentations and population receptive sizes in human primary visual cortex. Here we use func-tional MRI (fMRI) and population receptive field (pRF) modeling [6] to measure angular and ec-centric retinotopic representations and population receptive fields in primary visual cortex in healthy aging subjects ages 57 - 70 and in healthy young volunteers ages 24 - 36 (n = 9). Retinotopic stimuli consisted of black and white, drifting checkerboards comprising moving bars 11 deg in radius. Primary visual cortex (V1) was clearly identifiable along the calcarine sulcus in all hemispheres. There was a significant decrease in the surface area of V1 from 0 to 3 deg eccentricity in the aging subjects with respect to the young
Aims For catheter ablation of atrial fibrillation (AF), proper catheter positioning is crucial and depends on knowledge of pulmonary vein (PV) anatomy. The aim of this study was to assess PV spatial orientation and ostial shape by contrast-enhanced magnetic resonance angiography (CE-MRA).. Methods and results In 30 consecutive AF patients, CE-MRA was performed prior to ostial ablation. Using a centre-line technique, the PV ostium was defined perpendicular to this centre-line. Minimal and maximal ostial diameters, ostial perimeter, and angles in the anatomical frontal and transverse planes were measured. Twenty-one patients had four separate PVs. In four patients, there was a distinct right-middle PV and in five a common left common PV was found. Left-sided PV ostia were smaller and more elliptical than right-sided PVs. In the transverse plane, the ostia of both superior PVs were directed anteriorly (LS −15±13°, RS −13±11°) and both inferior PV ostia were directed posteriorly ...
BACKGROUND:. Premenstrual dysphoric disorder (PMDD) has generally not been associated with impulsive behavior. However, some studies suggest that women with PMDD have higher impulsivity scores than healthy controls and that brain activity during response inhibition may vary across the menstrual cycle. Therefore, our aim was to unravel potentially important cognitive aspects of PMDD by investigating brain activity during response inhibition in women with PMDD and healthy controls in relation to menstrual cycle phase.. METHODS:. Fourteen PMDD patients and 13 healthy controls performed a Go/NoGo task to measure brain activity during response inhibition by use of event-related functional magnetic resonance imaging.. RESULTS:. Women with PMDD displayed decreased activity during both menstrual cycle phases compared to healthy controls in several task-related parietal areas. A ...
Detail záznamu - 1H magnetic resonance spectroscopy study of different histological types of human meningiomas in vitro - Detailné zobrazenie záznamu - Slovenská lekárska knižnica
Jen et al. (2004) carried out high resolution MRI in eight patients from four families with HGPPS including two consanguineous families from Saudi Arabia and a third from unknown Arab origin. Abnormal flattening of the basis pontis and hypoplasia in the pontine tegmentum were evident on sagittal sections. The structural alterations in caudal pons suggested potential involvement of the abducens nuclei, the medial longitudinal fasciculus, and the pontine paramedian reticular formation. The medulla appeared abnormally butterfly-like, with anterior flattening and an unusual midline cleft. The abducens nerves were visualized bilaterally in the extra-axial space, and orbital MRI demonstrated normal extraocular muscle configuration and size, as well as the presence of apparently normal intraorbital motor nerves to the medial and lateral rectus muscles. Jen et al. (2004) concluded that the absence of bulging of abducens nuclei into the fourth ventricle observed in HGPPS patients likely represents ...
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leucoencephalopathy (CADASIL), familial vascular leukoencephalopathy. Cerebral Autosomal Dominant Arteriopathy
TY - JOUR. T1 - Meta-Analysis of Transthoracic Echocardiography Versus Cardiac Magnetic Resonance for the Assessment of Aortic Regurgitation After Transcatheter Aortic Valve Implantation. AU - Papanastasiou, Christos A.. AU - Kokkinidis, Damianos G.. AU - Jonnalagadda, Anil K.. AU - Oikonomou, Evangelos K.. AU - Kampaktsis, Polydoros N.. AU - Garcia, Mario J.. AU - Myerson, Saul G.. AU - Karamitsos, Theodoros D.. PY - 2019/10/15. Y1 - 2019/10/15. N2 - Residual aortic regurgitation (AR) is a major complication after transcatheter aortic valve implantation (TAVI). Although the echocardiographic assessment of post-TAVI AR remains challenging, cardiac magnetic resonance (CMR) allows direct quantification of AR. The aim of this study was to review the level of agreement between 2-dimensional transthoracic echocardiography (2D TTE) and CMR on grading the severity of AR after TAVI, and determine the accuracy of TTE in detecting moderate or severe ...
Magnetic resonance cholangiopancreatography (MRCP) is a medical imaging technique that uses magnetic resonance imaging to visualize the biliary and pancreatic ducts in a non-invasive manner. This procedure can be used to determine if gallstones are lodged in any of the ducts surrounding the gallbladder. It was introduced in 1991. MRCP makes use of heavily T2-weighted MRI pulse sequences. These sequences show high signal in static or slow moving fluids within the gallbladder, biliary ducts and pancreatic duct, with low signal of surrounding tissue. In the diagnosis of pancreatic disorders, MRCP is a much less invasive investigation when compared to endoscopic retrograde cholangiopancreatography (ERCP). Although both techniques can image the ductal system in detail, MRCP also allows imaging of the surrounding parenchyma. In a study from 2008, ...
The objective of this study was to investigate the relationship of cartilage loss and bone marrow lesions (BMLs) in the medial and lateral patellofemoral joint (PFJ) to knee pain. The location of full-thickness cartilage loss and BMLs in the PFJ on knee magnetic resonance imaging (MRIs) from the Multicenter Osteoarthritis (MOST) and Framingham Osteoarthritis (FOA) Studies were categorized as no damage, isolated medial, isolated lateral, or both medial and lateral (mixed). The relationship of MRI lesions in each PFJ region to prevalent knee pain were determined. Differences in knee pain severity were compared among categories of PFJ full-thickness cartilage loss and BMLs using quantile regression. In MOST (n=1137 knees), compared with knees without full-thickness cartilage loss, knees with isolated lateral or mixed PFJ full-thickness cartilage loss had 1.9 (1.3, 2.8) and 1.9 (1.2, 2.9) times the odds of knee pain, respectively, while isolated ...
We evaluated the diagnostic capability of a multimodal spectroscopic approach for classifying normal brain tissue and epileptogenic focal cortical dysplasia in children. We employed fluorescence spectroscopy at two excitation wavelengths (378 nm and 445 nm) and Raman spectroscopy (at 785 nm excitation) for acquiring fluorescence and Raman spectra from 10 normal brains, 16 focal cortical dysplasia specimens and 1 cortical tuber tissue sites using a custom-built multimodal optical point spectroscopic system. We used principal component analysis combined with leave-one-sample-out-cross-validation for tissue classification. The study resulted in 100% sensitivity and 90% specificity using the information obtained from fluorescence at two distinct wavelengths and Raman spectroscopy for discriminating normal brain tissue and focal cortical dysplasia. Our results demonstrate that this methodology has the potential to be applied ...
OBJECTIVES: We hypothesized that common variants in the collagen genes COL4A1/COL4A2 are associated with sporadic forms of cerebral small vessel disease. METHODS: We conducted meta-analyses of existing genotype data among individuals of European ancestry to determine associations of 1,070 common single nucleotide polymorphisms (SNPs) in the COL4A1/COL4A2 genomic region with the following: intracerebral hemorrhage and its subtypes (deep, lobar) (1,545 cases, 1,485 controls); ischemic stroke and its subtypes (cardioembolic, large vessel disease, lacunar) (12,389 cases, 62,004 controls); and white matter hyperintensities (2,733 individuals with ischemic stroke and 9,361 from population-based cohorts with brain MRI data). We calculated a statistical significance threshold that accounted for multiple testing and linkage disequilibrium between SNPs (p | 0.000084). RESULTS: Three intronic SNPs in COL4A2 were significantly associated with deep intracerebral hemorrhage (lead SNP odds ratio [OR] 1.29, ...
The posterior spinal cord contains longer perforating arteries that might be more susceptible to the effects of CADASIL vasculopathy. This explains the clinical (predominantly dorsal column involvement and motor deficit) and imaging features compared with those in the more common anterior spinal cord infarction (predominantly spinothalamic tract involvement and motor deficit). The stepwise progression could be explained by sequential involvement of perforating spinal cord arteries. Her clinical improvement is likely attributable to the combination of corticosteroid-responsive peri-ischaemic inflammatory changes and natural recovery.. Spinal cord involvement in CADASIL is well recognised but rare. In a UK cohort of 200 patients, there were no cases of spinal cord infarction.1 An anterior spinal cord infarct occurred in an Irish patient with probable CADASIL who had a history of severe migrainous headaches.7 A cervical spinal cord MRI study showed no abnormalities in 25 ...
Few data are available concerning structural changes at the hip observed by magnetic resonance imaging (MRI) in people with or without hip osteoarthritis (OA). The aim of this study was to compare cartilage volume and the presence of cartilage defects and bone marrow lesions (BMLs) in participants with and without diagnosed hip OA. Femoral head cartilage volume was measured by MRI for 141 community-based persons with no diagnosed hip OA, and 19 with diagnosed hip OA. Cartilage defects and BMLs were regionally scored at the femoral head and acetabulum. Compared with those without diagnosed hip OA, people with diagnosed hip OA had less femoral head cartilage volume (1763 mm3 versus 3343 mm3; p |0.001) and more prevalent cartilage defects and BMLs (all p ≤0.05) at all sites other than the central inferomedial region of the femoral head. In those with no diagnosed hip OA, cartilage defects in the anterior and central superolateral region of the ...
Anti-angiogenic therapy is efficacious in metastatic renal cell carcinoma (mRCC). However, the ability of anti-angiogenic drugs to delay tumor progression and extend survival is limited, due to either innate or acquired drug resistance. Furthermore, there are currently no validated biomarkers that predict which mRCC patients will benefit from anti-angiogenic therapy. Here we exploit susceptibility contrast magnetic resonance imaging (SC-MRI) using intravascular ultrasmall superparamagnetic iron oxide particles to quantify and evaluate tumor fractional blood volume (fBV) as a non-invasive imaging biomarker of response to the anti-angiogenic drug sunitinib. We also interrogate the vascular phenotype of RCC xenografts exhibiting acquired resistance to sunitinib. SC-MRI of 786-0 xenografts prior to and two weeks after daily treatment with 40mg/kg sunitinib revealed a 71% (p,0.01) reduction in ...
This review has examined the spatial and temporal neural activation of speech comprehension. Six theories on speech comprehension were selected and reviewed. The most fundamental structures for speech comprehension are the superior temporal gyrus, the fusiform gyrus, the temporal pole, the temporoparietal junction, and the inferior frontal gyrus. Considering temporal aspects of processes, the N400 ERP effect indicates semantic violations, and the P600 indicates re-evaluation of a word due to ambiguity or syntax error. The dual-route processing model provides the most accurate account of neural correlates and streams of activation necessary for speech comprehension, while also being compatible with both the reviewed studies and the reviewed theories. The integrated theory of language production and comprehension provides a contemporary theory of speech production and comprehension with roots in computational neuroscience, which in conjunction with the dual-route processing model could drive the ...

Homepage of Gopikrishna Deshpande - gopikrishna79Homepage of Gopikrishna Deshpande - gopikrishna79

Functional Magnetic Resonance Imaging (fMRI). · Multimodal Imaging and Data Fusion (e.g. Electroencephalography (EEG) and fMRI) ... A functional magnetic resonance imaging effective connectivity study", Human Brain Mapping, vol. 37(2), pp. 663-77, 2016. ... AM Thompkins, G Deshpande, P Waggoner, JS Katz, "Functional magnetic resonance imaging of the domestic dog: Research, ... A 7T functional Magnetic Resonance Imaging (fMRI) Study", Frontiers in Neuroscience, vol. 11, pp. 512, 2017. ...
more infohttps://sites.google.com/site/gopikrishna79/home/gopikrishna-deshpande/

Connectivity and functional profiling of abnormal brain structures in pedophilia.  - PubMed - NCBIConnectivity and functional profiling of abnormal brain structures in pedophilia. - PubMed - NCBI

Hum Brain Mapp. 2015 Jun;36(6):2374-86. doi: 10.1002/hbm.22777. Epub 2015 Mar 2. Research Support, N.I.H., Extramural; Research ... functional connectivity; functional magnetic resonance imaging (fMRI); meta-analytic connectivity modeling (MACM); neuroimaging ... The present multimodal integration of brain structure and function analyses links sexual and nonsexual psychopathology in ... Connectivity and functional profiling of abnormal brain structures in pedophilia.. Poeppl TB1, Eickhoff SB, Fox PT, Laird AR, ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/25733379

Temporal kernel CCA and its application in multimodal neuronal data analysis | SpringerLinkTemporal kernel CCA and its application in multimodal neuronal data analysis | SpringerLink

Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magnetic Resonance in ... Simultaneous recording of neuronal signals and functional NMR imaging. Magnetic Resonance Imaging. Google Scholar ... In the experiments, we simultaneously performed electrode recordings and functional magnetic resonance imaging (fMRI) in ... Logothetis, N. K., Guggenberger, H., Peled, S., & Pauls, J. (1999). Functional imaging of the monkey brain. Nature Neuroscience ...
more infohttps://link.springer.com/article/10.1007%2Fs10994-009-5153-3

Cortical mapping by functional magnetic resonance imaging in patients with brain tumors | SpringerLinkCortical mapping by functional magnetic resonance imaging in patients with brain tumors | SpringerLink

The aim of our study was to establish the effectiveness of the functional MRI (fMRI) technique in comparison with ... Janin P, Morandi X, Fleig MS et al (2002) Integration of sulcal and functional information for multimodal neuronavigation. J ... Atlas SW, Howard RS, Maldjian J et al (1996) Functional magnetic resonance imaging of regional brain activity in patients with ... Cortical mapping by functional magnetic resonance imaging in patients with brain tumors. ...
more infohttps://link.springer.com/article/10.1007%2Fs00330-004-2565-0

Multimodal Neuroimaging of Treatment Effects in Adolescent Mania - Tabular View - ClinicalTrials.govMultimodal Neuroimaging of Treatment Effects in Adolescent Mania - Tabular View - ClinicalTrials.gov

The investigators will use functional magnetic resonance imaging (fMRI) to examine brain activation during an attentional task. ... The purpose of this study is to use magnetic resonance imaging (MRI) to examine brain structure, function and chemistry in ... Multimodal Neuroimaging of Treatment Effects in Adolescent Mania. Official Title ICMJE Multimodal Neuroimaging of Treatment ... Multimodal Neuroimaging of Treatment Effects in Adolescent Mania. The safety and scientific validity of this study is the ...
more infohttps://clinicaltrials.gov/ct2/show/record/NCT00893581?show_rss=Y&sel_rss=mod14

frangou-s - PubMed - NCBIfrangou-s - PubMed - NCBI

Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and ... intracortical myelin organization in the living human brain determined by in vivo ultra-high field magnetic resonance imaging. ... The Integration of Functional Brain Activity from Adolescence to Adulthood.. Kundu P, Benson BE, Rosen D, Frangou S, Leibenluft ... Baseline brain structural and functional predictors of clinical outcome in the early course of schizophrenia. ...
more infohttps://www.ncbi.nlm.nih.gov/pubmed/?term=frangou-s

A Comparison Study of the Efficacy and Tolerability of Depakote ER and Depakote DRA Comparison Study of the Efficacy and Tolerability of Depakote ER and Depakote DR

Multimodal Brain Changes in First-Episode Mania: A Voxel-Based Morphometry, Functional Magnetic Resonance Imaging, and ... Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether ... Bipolar disorder, also known as manic-depressive illness, is a brain disorder that causes unusual shifts in mood, energy, ...
more infohttps://www.bioportfolio.com/resources/trial/107133/A-Comparison-Study-of-the-Efficacy-and-Tolerability-of-Depakote-ER-and.html

A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with...A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with...

Fox, M. D., Raichle, M. E. Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging. Nat ... Dill, T. Contraindications to magnetic resonance imaging: non-invasive imaging. Heart Br. Card. Soc. 94, (7), 943-948 (2008). ... A Multimodal Imaging- and Stimulation-based Method of Evaluating Connectivity-related Brain Excitability in Patients with ... The effect of stimulus intensity on brain responses evoked by transcranial magnetic stimulation. Hum. Brain Mapp. 21, (3), 154- ...
more infohttps://www.jove.com/video/53727/epilepsi-hastalarnda-beyin-uyarlabilmenin-balant-ile-ilgili?language=Turkish

Multimodal voxel-based meta-analysis of structural and functional magnetic resonance imaging studies in those at elevated...Multimodal voxel-based meta-analysis of structural and functional magnetic resonance imaging studies in those at elevated...

We searched the literature for studies reporting whole brain voxel-based morphometry (VBM) or functional magnetic resonance ... A multi-modal imaging meta-analysis was used to highlight brain regions with both structural and functional abnormalities. ... identified regional abnormalities of functional brain response. Similarly, an ES-SDM meta-analysis was conducted on VBM studies ... The multimodal analysis revealed relatives had decreased grey matter with hyper-activation in the left inferior frontal gyrus/ ...
more infohttps://www.semanticscholar.org/paper/Multimodal-voxel-based-meta-analysis-of-structural-Cooper-Barker/dd08db654365a8601f5a59e18fafe16a931e62fc

Kristoffer Hougaard Madsen - Projects
     - DTU Research DatabaseKristoffer Hougaard Madsen - Projects - DTU Research Database

Mapping the functional integration in the human basal ganglia by means of multi-modal magnetic resonance imaging. Andersen, K. ... Integrative multimodal brain imaging. Rasmussen, P. M., Hansen, L. K., Madsen, K. H., Lund, T. E., Larsen, J. & Siebner, H. R. ... Motion-insensitive Magnetic Resonance Imaging. Andersen, M., Hanson, L. G., Madsen, K. H., Thielscher, A., Ringgaard, S. & ... Prospective Motion Correction in Magnetic Resonance Imaging. Laustsen, M., Hanson, L. G., Madsen, K. H. & Xue, R. ...
more infohttps://orbit.dtu.dk/en/persons/kristoffer-hougaard-madsen/projects/

Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of...Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of...

"Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of ... The brain vital ities, such as functional magnetic resonance imaging sign framework employs a portable, low-density EEG sys- ( ... The brain vital ities, such as functional magnetic resonance imaging sign framework employs a portable, low-density EEG sys- ( ... phy; fMRI: functional magnetic resonance imaging; MCI: mild cognitive impair- 3. Duncan CC, et al. Event-related potentials in ...
more infohttps://www.deepdyve.com/lp/springer_journal/multimodal-characterization-of-the-semantic-n400-response-within-a-DEcZo0WybT

Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of...Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of...

"Multimodal characterization of the semantic N400 response within a rapid evaluation brain vital sign framework, Journal of ... The brain vital ities, such as functional magnetic resonance imaging sign framework employs a portable, low-density EEG sys- ( ... The brain vital ities, such as functional magnetic resonance imaging sign framework employs a portable, low-density EEG sys- ( ... phy; fMRI: functional magnetic resonance imaging; MCI: mild cognitive impair- 3. Duncan CC, et al. Event-related potentials in ...
more infohttps://www.deepdyve.com/lp/springer-journals/multimodal-characterization-of-the-semantic-n400-response-within-a-DEcZo0WybT

Creative visualization - WikipediaCreative visualization - Wikipedia

... a functional magnetic resonance imaging study. Neuroscience, Vol. 152, No. 1,2008, pp29-39. Juttner, M., and Rentschler, I., ... Behavioral and Brain Sciences, Vol. 25, No. 2, 2002, pp197-198. Juttner, M., and Rentschler, I., Imagery in multi-modal object ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. Kosslyn, S. M., Image ... Kosslyn, S. M., Image and brain: The resolution of the imagery debate. Cambridge, MA: MIT Press, 1994. Kosslyn, S. M., Ganis, G ...
more infohttps://en.wikipedia.org/wiki/Creative_visualization

13th International Conference on Myasthenia Gravis | The New York Academy of Sciences13th International Conference on Myasthenia Gravis | The New York Academy of Sciences

This symposium explores these structural, functional, and biochemical events that precede and may predict both AD and amnestic ... A multimodal imaging approach is employed, making use of functional magnetic resonance imaging and structural imaging methods ... to understanding how measurable functional deficits in the brain might be detected behaviorally, and to establishing and ... The advent of magnetic resonance diffusion tensor imaging (MR-DTI) has made it possible to explore AD-based WM microstructural ...
more infohttps://www.nyas.org/events/2012/13th-international-conference-on-myasthenia-gravis/

People | Psychological Sciences | Vanderbilt UniversityPeople | Psychological Sciences | Vanderbilt University

She integrates multimodal measures such as functional magnetic resonance imaging (fMRI), cerebral blood flow, brain anatomy, ... Kaczkurkin, A. N., Raznahan, A., & Satterthwaite, T. D. (2018). Sex differences in the developing brain: Insights from ... 1) Investigate abnormal brain anatomy and functioning in anxiety and depressive disorders. ... Merit Abstract Award for Top-Ranking Submissions, Organization for Human Brain Mapping (2017) ...
more infohttps://www.vanderbilt.edu/psychological_sciences/bio/antonia-kaczkurkin

CDC - Chronic Kidney Disease - Data SourcesCDC - Chronic Kidney Disease - Data Sources

... multimodal magnetic resonance imaging (MRI) of the brain, functional connectivity, and blood flow. Participants were included ... NiCK Study (Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney ... NiCK Study (Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney ... The Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease ...
more infohttps://nccd.cdc.gov/CKD/help.aspx?section=D

CDC Surveillance System: eGFR and Neurocognitive Performance in Children and Young Adults with CKDCDC Surveillance System: eGFR and Neurocognitive Performance in Children and Young Adults with CKD

... multimodal magnetic resonance imaging (MRI) of the brain, functional connectivity, and blood flow. Participants were included ... Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease ( ... Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease ( ... The Neurocognitive Assessment and Magnetic Resonance Imaging Analysis of Children and Young Adults with Chronic Kidney Disease ...
more infohttps://nccd.cdc.gov/CKD/detail.aspx?QNum=Q671

Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine

Here, we used a multimodal approach of electrocorticography (ECoG), high-resolution functional magnetic resonance imaging (fMRI ... we use functional magnetic resonance imaging (fMRI), intracranial electrocorticography (ECoG), and electrical brain stimulation ... Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging NATURE MEDICINE Mezer ... response measured with functional magnetic resonance imaging (fMRI). We set out to explain the full set of measurements by ...
more infohttps://med.stanford.edu/profiles/neurology/josef-parvizi/

Electrical Stimulation of Human Fusiform Face-Selective Regions Distorts Face Perception | Journal of NeuroscienceElectrical Stimulation of Human Fusiform Face-Selective Regions Distorts Face Perception | Journal of Neuroscience

Here, we used a multimodal approach of electrocorticography (ECoG), high-resolution functional magnetic resonance imaging (fMRI ... Post-implant CT images were aligned to the preop MRI anatomical brain volume (Hermes et al., 2010). Electrodes were visualized ... and functional magnetic resonance imaging (fMRI) studies (Kanwisher et al., 1997) in humans reveal stronger FG activations to ... Functional responses are shown on the patients native anatomy. Electrodes used for EBS (1 and 2) are labeled in each image for ...
more infohttp://www.jneurosci.org/content/32/43/14915.full

Community Academic Profiles - Faculty & Researchers - Stanford MedicineCommunity Academic Profiles - Faculty & Researchers - Stanford Medicine

Here, we used a multimodal approach of electrocorticography (ECoG), high-resolution functional magnetic resonance imaging (fMRI ... we use functional magnetic resonance imaging (fMRI), intracranial electrocorticography (ECoG), and electrical brain stimulation ... Quantifying the local tissue volume and composition in individual brains with magnetic resonance imaging NATURE MEDICINE Mezer ... response measured with functional magnetic resonance imaging (fMRI). We set out to explain the full set of measurements by ...
more infohttps://med.stanford.edu/profiles/neurology/josef-parvizi

Plus itPlus it

In this functional magnetic resonance imaging study of human subjects, we first identified brain areas that responded to both ... of functional magnetic resonance imaging (fMRI) data to probe multimodal regions for neural representations that were both ... 2005) Functional imaging of human crossmodal identification and object recognition. Exp Brain Res 166:559-571. ... 2001) A global optimisation method for robust affine registration of brain images. Med Image Anal 5:143-156. ...
more infohttp://www.jneurosci.org/content/32/47/16629

CIBCB2018 Special SessionsCIBCB2018 Special Sessions

Functional magnetic resonance imaging (fMRI) * Electroencephalography (EEG) * Magnetoencephalography (MEG) * Positron Emission ... Intersubject Functional/Structural Brain Alignments * Brain-Computer Interfaces * Reverse Inference * Multimodal neuroimaging ... This intersection of information sciences and neuroscience is a promising scientific exploration of the brain with applications ... and medical imaging and pattern recognition.. The main aim of this special session is to bring together both experts and new- ...
more infohttp://cibcb.org/CIBCB2018/index-6.html

5th European Conference of the International Federation for Medical and Biological Engineering | Ebook | Ellibs Ebookstore5th European Conference of the International Federation for Medical and Biological Engineering | Ebook | Ellibs Ebookstore

Enhancing Functional Cohesiveness in Renal Dynamic Contrast Enhanced-Magnetic Resonance Imaging (DCE-MRI) by Extraction of ... Segmentation of Nuclei in Hepatic Histological Images Using Multimodal Method. M. Takahashi, J. Koichi, Y. Makino, T. Kitani, M ... Method for Testing the Brain. H. Hinrikus, M. Bachmann, J. Lass, V. Tuulik, R. Ubar. 311. Determination of Human Brain-based ... Influence of Magnetic Fields on U937 Cells Viability. K. Wójcik, J. Kaszuba-Zwoińska, E. Rokita, P. Thor, P. Chorobik, Z. ...
more infohttps://www.ellibs.com/book/9783642235085/5th-european-conference-of-the-international-federation-for-medical-and-biological-engineering

Frontiers | A Hierarchical Bayesian Model for the Identification of PET Markers Associated to the Prediction of Surgical...Frontiers | A Hierarchical Bayesian Model for the Identification of PET Markers Associated to the Prediction of Surgical...

It also identifies imaging biomarkers characterizing the pathological states of the subjects. In the data application, we ... together with a set of discriminatory brain regions that can be used to distinguish the latent subgroups. We show that the ... It also identifies imaging biomarkers characterizing the pathological states of the subjects. In the data application, we ... imaging biomarkers and evaluates the association of those states with a clinical outcome. We consider data from a study on ...
more infohttps://www.frontiersin.org/articles/10.3389/fnins.2017.00669/full

Frontiers | Multi-modal representation of effector modality in frontal cortex during rule switching | Human NeuroscienceFrontiers | Multi-modal representation of effector modality in frontal cortex during rule switching | Human Neuroscience

... study which investigated whether brain areas involved in updating task rules within the frontal lobe of the cerebral cortex ... We report a functional magnetic resonance imaging study which investigated whether brain areas involved in updating task rules ... We report a functional magnetic resonance imaging (fMRI) ... We report a functional magnetic resonance imaging (fMRI) study ... Multi-modal representation of effector modality in frontal cortex during rule switching. Timothy L. Hodgson1*, Benjamin A. ...
more infohttps://www.frontiersin.org/articles/10.3389/fnhum.2015.00486/full
  • The chance to investigate the pathophysiology of different mechanisms involved in epilepsy and to find different therapeutic approaches is allowed by the used of new multimodal examinations. (frontiersin.org)
  • The aim of this topic is to develop methods to integrate the results of these techniques and quantify the performance of new multimodal approaches of analysis compared with the conventional ones in order to improve the identification of activated area. (frontiersin.org)
  • A great deal of progress has been made by using modeling approaches that systematically capture the statistics of a problem domain from a collection of examples and then use these statistics to interpret novel images. (na-mic.org)
  • Furthermore, the combination of textural features derived from both imaging approaches has not yet been widely studied. (bham.ac.uk)
  • Our findings, consistent with functional approaches to animal communication and observations made on threat displays in small-scale societies, challenge the Western assumption that "fear" gasping faces uniformly express fear or signal submission across cultures. (dericbownds.net)
  • In this thesis, the aim of the research is to investigate TA based on multi-centre multimodal MRI, in order to provide more comprehensive information and develop an automated processing framework for the classification of childhood brain tumours. (bham.ac.uk)
  • I am a chartered physiotherapist, trials methodologist and Director for Mind, Brain, Neuroscience Trials in the Centre for Trials Research (CTR) at Cardiff University. (cardiff.ac.uk)
  • The combinatorial use of biomarkers derived from biological fluids, such as cerebrospinal fluid (CSF), with advanced molecular imaging and neuropsychological testing may eventually achieve the diagnostic sensitivity and specificity necessary to identify people in the earliest stages of the disease when drug modification is most likely possible. (springer.com)
  • Using functional and structural imaging techniques, psychophysiological measurements and neuropsychological tests, the team investigates the neuropsychobiological correlates of cognition and various emotions, taking into account the influence of hormones. (ukaachen.de)
  • The sensitivity of the fMRI technique in brain mapping increases when using both motor and sensory paradigms in the same patient. (springer.com)
  • Krings T, Reul J, Klusmann A et al (1998) Functional magnetic resonance imaging of sensory motor cortex for image-guided neurosurgical intervention. (springer.com)
  • In guided imagery, a trained practitioner or teacher helps a participant or patient to evoke and generate mental images that simulate or re-create the sensory perception of sights, sounds, tastes, smells, movements, and touch, as well as imaginative or mental content that the participating subject experiences as defying conventional sensory categories. (wikipedia.org)
  • We measured brain activity with functional magnetic resonance imaging before, while, and after participants learned to associate either sensory redundant stimuli, i.e. voices and faces, or arbitrary multimodal combinations, i.e. voices and written names, ring tones, and cell phones or brand names of these cell phones. (plos.org)
  • This suggests that information from different sensory channels converges somewhere in the brain to form modality-invariant representations, i.e., representations that reflect an object independently of the modality through which it has been apprehended. (jneurosci.org)
  • We show that the natural beta1 rhythm (12 to 20 Hz) of the PC provides a substrate for an episodic buffer that can synergistically combine executive commands (e.g., from PFC) and multimodal information into a flexible and updatable representation of recent sensory inputs. (pnas.org)
  • Within this framework, WM is seen as having 4 core components: a central executive, 2 slave systems specifically responsible for representing visuospatial and auditory (language) information, and an episodic buffer to synergistically combine both executive commands and multimodal information into a temporary, manipulable representation of recent sensory inputs relevant to the currently attended task. (pnas.org)
  • Reflecting this complexity, the first few hundred milliseconds of processing a stimulus feature a large cascade of rapidly activated brain regions, transforming sensory representations at each step. (royalsocietypublishing.org)
  • Structural MRI was used to calculate voxel-based intensity of grey matter (GM) and white matter (WM) across the entire brain and compared among groups. (hku.hk)
  • We applied an integrative multimodal imaging approach during acupuncture. (semanticscholar.org)
  • Although imbalanced functional integration has been increasingly reported in major depressive disorder (MDD), there still lacks a general framework to characterize common characteristic and origin shared by the integrative disturbances. (readbyqxmd.com)
  • This review highlights advancements in biological fluid and imaging biomarkers that are moving the field towards achieving the goal of a preclinical detection of AD. (springer.com)
  • Finally, new advances in tau PET imaging and novel fluid biomarkers hold promise to increase biomarker reliability. (springer.com)
  • We believe that we can use brain images to obtain effective biomarkers for various brain disorders with the aid of developing computational methods and models. (alzforum.org)
  • Preliminary findings indicate abnormal brain structure and function. (nih.gov)
  • Brain structural and functional changes in bipolar disorder (BD) are well-established findings, but it is uncertain whether these changes are already present in first episode mania (FEM). (bioportfolio.com)
  • Computational brain-imaging studies of individuals at familial high risk for psychosis have provided interesting results, but interpreting these findings can be a challenge due to a number of factors. (semanticscholar.org)
  • Overall, our findings reveal a striking convergence of fMRI, ECoG, and EBS, which together offer a rare causal link between functional subsets of the human FG network and face perception. (jneurosci.org)
  • Collectively, these findings link age-related structural differences to age-related functional under- as well as overrecruitment. (diva-portal.org)
  • In 2016, Dr. Knight presented the initial findings from her research using sMRI to compare brain volumes in pediatric lupus patients with control patients at the 2016 ACR/ARHP Annual Meeting . (the-rheumatologist.org)
  • These findings demonstrate the utility and potential of using multimodal imaging techniques to define large-scale distributed brain networks, including those that demonstrate known hemispheric asymmetries in humans. (ox.ac.uk)
  • Specific Aim 1: To determine the effects of treatment with quetiapine or lithium on brain activation in adolescents. (clinicaltrials.gov)
  • Specific Aim 3: To determine the relationships among the changes in brain activation and neurometabolite measures, as well as symptomatic improvement in manic adolescents. (clinicaltrials.gov)
  • Hypotheses 1 & 2 predict that following 6 weeks of treatment with lithium or quetiapine, manic adolescents who demonstrate symptomatic improvement will exhibit normalized (decreased) VLPFC and ACC activation and increased activation of compensatory posterior attentional brain areas as well as normalization of VLPFC and ACC neurometabolite measures (increased NAA and decreased Glu levels) compared with those who do not experience symptomatic improvement and healthy adolescents. (clinicaltrials.gov)
  • Scalp EEG reflects the brain's electrical activity, and in particular post-synaptic potentials (see Inhibitory postsynaptic current and Excitatory postsynaptic potential) in the cerebral cortex, whereas fMRI is capable of detecting haemodynamic changes throughout the brain through the BOLD effect. (wikipedia.org)
  • We are an interdisciplinary lab based at Tufts University and the Martinos Center for Biomedical Imaging at Massachusetts General Hospital. (harvard.edu)
  • These replicated results show that brain function , brain wiring and structure are important in predicting different aspects of cognition. (medicalxpress.com)
  • EEG biofeedback is especially useful for treating neurological conditions such as ADHD, stress/anxiety, sleep disorders, epilepsy, traumatic brain injury. (brocku.ca)
  • Simultaneous EEG and fMRI recording and Electric Source Imaging (ESI) offer a less invasive alternative, since they provide valuable information to localize the brain regions generating interictal epileptiform activity. (frontiersin.org)
  • We therefore assessed DT-waking using NIRS during actual gait, and also using NIRS with simultaneous functional magnetic resonance imaging (fMRI) during simulated gait. (pubmedcentralcanada.ca)
  • 2014) Short repetition time multiband EPI with simultaneous pulse recording allows dynamic imaging of the cardiac pulsation signal. (nirs-fmri.net)
  • Methods To assess cerebral microstructure and resting functional activities in patients with idiopathic PD and VH, I compared PD patients with VH (PDVH) and PD patients without VH (PDnonVH), while healthy controls (HC) were also recruited for comparison. (hku.hk)
  • Magnetic resonance imaging methods that measure interregional brain signalling at rest have been advanced as powerful tools to probe organizational properties of functional networks. (biomedsearch.com)
  • Specifically, they covered statistical and mathematical methods associated with imaging reconstruction, imaging segmentation, imaging registration, and their applications. (samsi.info)
  • 2. Which short- and longer term consequences can be expected from improved self control over brain activation upon aggressive and antisocial behavior problems? (bioportfolio.com)
  • Though such imaging has potential in several areas, presently it is used for understanding the molecular behavior just before the organism starts showing the symptoms of a disease. (researchimpact.com)
  • Functional brain imaging studies of normal aging typically show age-related under- and overactivations during episodic memory tasks. (diva-portal.org)
  • Little is known about where in the brain the episodic buffer lies or about its underlying physiology. (pnas.org)
  • Hence users and developers can choose to engage the NA-MIC Kit at a variety of levels, including developing extensions which can be readily deployed to the broader biomedical imaging community. (na-mic.org)
  • In the present medical scenario majority of the diseases are being diagnosed and attended using biomedical imaging techniques. (researchimpact.com)
  • Intranasal drug administration is a noninvasive method that allows therapeutic agents that do not cross the blood-brain barrier to be delivered to the central nervous system (CNS). (asahq.org)
  • Yb,Er,Tm-based visual therapeutic platform was developed for imaging-guided synergistic cancer therapy. (thno.org)
  • Another research priority is the functional evaluation of therapeutic interventions using imaging techniques. (ukaachen.de)
  • Molecular imaging is useful for quantitative tests, assessing how much of a drug dosage is required for achieving the target, or how much time is taken for a given reaction. (researchimpact.com)
  • abstract = "Dopamine function and reward processing are highly interrelated and involve common brain regions afferent to the nucleus accumbens, within the mesolimbic pathway. (elsevier.com)
  • Abstract The central nervous system is protected by barriers which control the entry of compounds into the brain, thereby regulating brain homeostasis. (las.ac.cn)
  • Additionally, the initial signs of damage in the same brain regions for a subgroup of pediatric lupus patients without known neuropsychiatric impairment were also present, signifying potential subclinical effects of pSLE on the brain. (the-rheumatologist.org)
  • To challenge participants, sad mood was induced with keywords of personal negative life events in individuals with remitted depression [recurrent major depressive disorder (rMDD), n = and matched healthy controls (HCs, n = 30) during functional magnetic resonance imaging. (readbyqxmd.com)
  • Alternatively, we propose that genetic deficiency is not the only way to reduce protective factors in the brain which may function to keep microglial responses in check or regulate the sensitivity of DA neurons. (las.ac.cn)
  • We propose that physiological properties of the parietal cortex, which can produce a unique brain rhythm at low beta (12 to 20 Hz), make this cortex an excellent candidate for a substrate of such a buffer. (pnas.org)