Behavioral manifestations of cerebral dominance in which there is preferential use and superior functioning of either the left or the right side, as in the preferred use of the right hand or right foot.
Dominance of one cerebral hemisphere over the other in cerebral functions.
The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
A congenital abnormality in which organs in the THORAX and the ABDOMEN are opposite to their normal positions (situs solitus) due to lateral transposition. Normally the STOMACH and SPLEEN are on the left, LIVER on the right, the three-lobed right lung is on the right, and the two-lobed left lung on the left. Situs inversus has a familial pattern and has been associated with a number of genes related to microtubule-associated proteins.
The processes occurring in early development that direct morphogenesis. They specify the body plan ensuring that cells will proceed to differentiate, grow, and diversify in size and shape at the correct relative positions. Included are axial patterning, segmentation, compartment specification, limb position, organ boundary patterning, blood vessel patterning, etc.
The dorsal posterior subdivision of the diencephalon. The epithalamus is generally considered to include the habenular nuclei (HABENULA) and associated fiber bundles, the PINEAL BODY, and the epithelial roof of the third ventricle. The anterior and posterior paraventricular nuclei of the thalamus are included with the THALAMIC NUCLEI although they develop from the same pronuclear mass as the epithalamic nuclei and are sometimes considered part of the epithalamus.
Abnormal thoracoabdominal VISCERA arrangement (visceral heterotaxy) or malformation that involves additional CONGENITAL HEART DEFECTS (e.g., heart isomerism; DEXTROCARDIA) and/or abnormal SPLEEN (e.g., asplenia and polysplenia). Irregularities with the central nervous system, the skeleton and urinary tract are often associated with the syndrome.
The species Delphinapterus leucas, in the family Monodontidae, found primarily in the Arctic Ocean and adjoining seas. They are small WHALES lacking a dorsal fin.
A small protuberance at the dorsal, posterior corner of the wall of the THIRD VENTRICLE, adjacent to the dorsal THALAMUS and PINEAL BODY. It contains the habenular nuclei and is a major part of the epithalamus.
A family of rat kangaroos found in and around Australia. Genera include Potorous and Bettongia.
Signaling ligands that act in opposition to NODAL PROTEIN. During vertebrate development they regulate the degree of left-right asymmetry by controlling the spatiotemporal influence of NODAL PROTEIN.
Tests for central hearing disorders based on the competing message technique (binaural separation).
An exotic species of the family CYPRINIDAE, originally from Asia, that has been introduced in North America. They are used in embryological studies and to study the effects of certain chemicals on development.
A verbal or nonverbal means of communicating ideas or feelings.
A group of islands in Melanesia constituting a French overseas territory. The group includes New Caledonia (the main island), Ile des Pins, Loyalty Island, and several other islet groups. The capital is Noumea. It was discovered by Captain Cook in 1774 and visited by various navigators, explorers, and traders from 1792 to 1840. Occupied by the French in 1853, it was set up as a penal colony 1864-94. In 1946 it was made a French overseas territory. It was named by Captain Cook with the 5th and 6th century A.D. Latin name for Scotland, Caledonia. (From Webster's New Geographical Dictionary, 1988, p830 & Room, Brewer's Dictionary of Names, 1992, p375)
Proteins obtained from the ZEBRAFISH. Many of the proteins in this species have been the subject of studies involving basic embryological development (EMBRYOLOGY).
A growth differentiation factor that plays a role in the genesis of left-right asymmetry during vertebrate development. Evidence for this role is seen in MICE where loss of growth differentiation factor 1 function results in right-left isomerism of visceral organs. In HUMANS heterozygous loss of growth differentiation factor 1 function has been associated with CONGENITAL HEART DEFECTS and TRANSPOSITION OF GREAT VESSELS.
Populations of thin, motile processes found covering the surface of ciliates (CILIOPHORA) or the free surface of the cells making up ciliated EPITHELIUM. Each cilium arises from a basic granule in the superficial layer of CYTOPLASM. The movement of cilia propels ciliates through the liquid in which they live. The movement of cilia on a ciliated epithelium serves to propel a surface layer of mucus or fluid. (King & Stansfield, A Dictionary of Genetics, 4th ed)
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Artery formed by the bifurcation of the BASILAR ARTERY. Branches of the posterior cerebral artery supply portions of the OCCIPITAL LOBE; PARIETAL LOBE; inferior temporal gyrus, brainstem, and CHOROID PLEXUS.
A barbiturate with hypnotic and sedative properties (but not antianxiety). Adverse effects are mainly a consequence of dose-related CNS depression and the risk of dependence with continued use is high. (From Martindale, The Extra Pharmacopoeia, 30th ed, p565)
Common name for the largest birds in the order PASSERIFORMES, family Corvidae. These omnivorous black birds comprise most of the species in the genus Corvus, along with ravens and jackdaws (which are often also referred to as crows).
Substances and materials manufactured for use in various technologies and industries and for domestic use.
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
An autosomal recessive disorder characterized by a triad of DEXTROCARDIA; INFERTILITY; and SINUSITIS. The syndrome is caused by mutations of DYNEIN genes encoding motility proteins which are components of sperm tails, and CILIA in the respiratory and the reproductive tracts.
The developmental entity of a fertilized egg (ZYGOTE) in animal species other than MAMMALS. For chickens, use CHICK EMBRYO.
A localization-related (focal) form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe, most commonly from its mesial aspect. A wide variety of psychic phenomena may be associated, including illusions, hallucinations, dyscognitive states, and affective experiences. The majority of complex partial seizures (see EPILEPSY, COMPLEX PARTIAL) originate from the temporal lobes. Temporal lobe seizures may be classified by etiology as cryptogenic, familial, or symptomatic (i.e., related to an identified disease process or lesion). (From Adams et al., Principles of Neurology, 6th ed, p321)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A spectrum of septal defects involving the ATRIAL SEPTUM; VENTRICULAR SEPTUM; and the atrioventricular valves (TRICUSPID VALVE; BICUSPID VALVE). These defects are due to incomplete growth and fusion of the ENDOCARDIAL CUSHIONS which are important in the formation of two atrioventricular canals, site of future atrioventricular valves.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
Movement of a part of the body for the purpose of communication.
Tests designed to assess language behavior and abilities. They include tests of vocabulary, comprehension, grammar and functional use of language, e.g., Development Sentence Scoring, Receptive-Expressive Emergent Language Scale, Parsons Language Sample, Utah Test of Language Development, Michigan Language Inventory and Verbal Language Development Scale, Illinois Test of Psycholinguistic Abilities, Northwestern Syntax Screening Test, Peabody Picture Vocabulary Test, Ammons Full-Range Picture Vocabulary Test, and Assessment of Children's Language Comprehension.
A new pattern of perceptual or ideational material derived from past experience.
The ability to differentiate tones.
Developmental abnormalities involving structures of the heart. These defects are present at birth but may be discovered later in life.
Tumors or cancer of the RETINA.
The thin layer of GRAY MATTER on the surface of the CEREBRAL HEMISPHERES that develops from the TELENCEPHALON and folds into gyri and sulchi. It reaches its highest development in humans and is responsible for intellectual faculties and higher mental functions.
The measurement of magnetic fields over the head generated by electric currents in the brain. As in any electrical conductor, electric fields in the brain are accompanied by orthogonal magnetic fields. The measurement of these fields provides information about the localization of brain activity which is complementary to that provided by ELECTROENCEPHALOGRAPHY. Magnetoencephalography may be used alone or together with electroencephalography, for measurement of spontaneous or evoked activity, and for research or clinical purposes.
The process whereby auditory stimuli are selected, organized, and interpreted by the organism.
Dyneins that are responsible for ciliary and flagellar beating.
A malignant tumor arising from the nuclear layer of the retina that is the most common primary tumor of the eye in children. The tumor tends to occur in early childhood or infancy and may be present at birth. The majority are sporadic, but the condition may be transmitted as an autosomal dominant trait. Histologic features include dense cellularity, small round polygonal cells, and areas of calcification and necrosis. An abnormal pupil reflex (leukokoria); NYSTAGMUS, PATHOLOGIC; STRABISMUS; and visual loss represent common clinical characteristics of this condition. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2104)
A condition of an inequality of refractive power of the two eyes.
Lower lateral part of the cerebral hemisphere responsible for auditory, olfactory, and semantic processing. It is located inferior to the lateral fissure and anterior to the OCCIPITAL LOBE.
A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
Use of sound to elicit a response in the nervous system.
Common name for perch-like fish of the family Cichlidae, belonging to the suborder Labroidei, order PERCIFORMES.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
Proteins obtained from various species of Xenopus. Included here are proteins from the African clawed frog (XENOPUS LAEVIS). Many of these proteins have been the subject of scientific investigations in the area of MORPHOGENESIS and development.
A light-sensitive neuroendocrine organ attached to the roof of the THIRD VENTRICLE of the brain. The pineal gland secretes MELATONIN, other BIOGENIC AMINES and NEUROPEPTIDES.
Motion of an object in which either one or more points on a line are fixed. It is also the motion of a particle about a fixed point. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The coordination of a sensory or ideational (cognitive) process and a motor activity.
Any of the large interior organs in any one of the three great cavities of the body, especially in the abdomen.
Formation of differentiated cells and complicated tissue organization to provide specialized functions.
Bony structure of the mouth that holds the teeth. It consists of the MANDIBLE and the MAXILLA.
A front limb of a quadruped. (The Random House College Dictionary, 1980)
Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain.
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
Paired, segmented masses of MESENCHYME located on either side of the developing spinal cord (neural tube). Somites derive from PARAXIAL MESODERM and continue to increase in number during ORGANOGENESIS. Somites give rise to SKELETON (sclerotome); MUSCLES (myotome); and DERMIS (dermatome).
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
A cognitive disorder marked by an impaired ability to comprehend or express language in its written or spoken form. This condition is caused by diseases which affect the language areas of the dominant hemisphere. Clinical features are used to classify the various subtypes of this condition. General categories include receptive, expressive, and mixed forms of aphasia.
Receptors for ACTIVINS are membrane protein kinases belonging to the family of PROTEIN-SERINE-THREONINE KINASES, thus also named activin receptor-like kinases (ALK's). Activin receptors also bind TRANSFORMING GROWTH FACTOR BETA. As those transmembrane receptors of the TGF-beta superfamily (RECEPTORS, TRANSFORMING GROWTH FACTOR BETA), ALK's consist of two different but related protein kinases, Type I and Type II. Activins initiate cellular signal transduction by first binding to the type II receptors (ACTIVIN RECEPTORS, TYPE II ) which then recruit and phosphorylate the type I receptors (ACTIVIN RECEPTORS, TYPE I ) with subsequent activation of the type I kinase activity.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
The observable response an animal makes to any situation.
A nonspecific symptom of hearing disorder characterized by the sensation of buzzing, ringing, clicking, pulsations, and other noises in the ear. Objective tinnitus refers to noises generated from within the ear or adjacent structures that can be heard by other individuals. The term subjective tinnitus is used when the sound is audible only to the affected individual. Tinnitus may occur as a manifestation of COCHLEAR DISEASES; VESTIBULOCOCHLEAR NERVE DISEASES; INTRACRANIAL HYPERTENSION; CRANIOCEREBRAL TRAUMA; and other conditions.
The time from the onset of a stimulus until a response is observed.
Includes both producing and responding to words, either written or spoken.
The common chimpanzee, a species of the genus Pan, family HOMINIDAE. It lives in Africa, primarily in the tropical rainforests. There are a number of recognized subspecies.
Tests designed to assess neurological function associated with certain behaviors. They are used in diagnosing brain dysfunction or damage and central nervous system disorders or injury.
The hollow, muscular organ that maintains the circulation of the blood.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The part of the cerebral hemisphere anterior to the central sulcus, and anterior and superior to the lateral sulcus.
Subjectively experienced sensations in the absence of an appropriate stimulus, but which are regarded by the individual as real. They may be of organic origin or associated with MENTAL DISORDERS.
The developmental stage that follows BLASTULA or BLASTOCYST. It is characterized by the morphogenetic cell movements including invagination, ingression, and involution. Gastrulation begins with the formation of the PRIMITIVE STREAK, and ends with the formation of three GERM LAYERS, the body plan of the mature organism.
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL).
Upper central part of the cerebral hemisphere. It is located posterior to central sulcus, anterior to the OCCIPITAL LOBE, and superior to the TEMPORAL LOBES.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
A statistical technique that isolates and assesses the contributions of categorical independent variables to variation in the mean of a continuous dependent variable.
The distal part of the arm beyond the wrist in humans and primates, that includes the palm, fingers, and thumb.
Performance of complex motor acts.
The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS.
Area of the FRONTAL LOBE concerned with primary motor control located in the dorsal PRECENTRAL GYRUS immediately anterior to the central sulcus. It is comprised of three areas: the primary motor cortex located on the anterior paracentral lobule on the medial surface of the brain; the premotor cortex located anterior to the primary motor cortex; and the supplementary motor area located on the midline surface of the hemisphere anterior to the primary motor cortex.
The detailed examination of observable activity or behavior associated with the execution or completion of a required function or unit of work.
Those characteristics that distinguish one SEX from the other. The primary sex characteristics are the OVARIES and TESTES and their related hormones. Secondary sex characteristics are those which are masculine or feminine but not directly related to reproduction.
Family of the suborder HAPLORHINI (Anthropoidea) comprising bipedal primate MAMMALS. It includes modern man (HOMO SAPIENS) and the great apes: gorillas (GORILLA GORILLA), chimpanzees (PAN PANISCUS and PAN TROGLODYTES), and orangutans (PONGO PYGMAEUS).
Morphological and physiological development of EMBRYOS.
Non-invasive method of vascular imaging and determination of internal anatomy without injection of contrast media or radiation exposure. The technique is used especially in CEREBRAL ANGIOGRAPHY as well as for studies of other vascular structures.
One of the two types of ACTIVIN RECEPTORS or activin receptor-like kinases (ALK'S). There are several type I activin receptors. The major active ones are ALK-2 (ActR-IA) and ALK-4 (ActR-IB).
The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY.
An aquatic genus of the family, Pipidae, occurring in Africa and distinguished by having black horny claws on three inner hind toes.
Elements of limited time intervals, contributing to particular results or situations.
The process of cumulative change over successive generations through which organisms acquire their distinguishing morphological and physiological characteristics.
A class of nerve fibers as defined by their structure, specifically the nerve sheath arrangement. The AXONS of the myelinated nerve fibers are completely encased in a MYELIN SHEATH. They are fibers of relatively large and varied diameters. Their NEURAL CONDUCTION rates are faster than those of the unmyelinated nerve fibers (NERVE FIBERS, UNMYELINATED). Myelinated nerve fibers are present in somatic and autonomic nerves.
An important regulator of GENE EXPRESSION during growth and development, and in NEOPLASMS. Tretinoin, also known as retinoic acid and derived from maternal VITAMIN A, is essential for normal GROWTH; and EMBRYONIC DEVELOPMENT. An excess of tretinoin can be teratogenic. It is used in the treatment of PSORIASIS; ACNE VULGARIS; and several other SKIN DISEASES. It has also been approved for use in promyelocytic leukemia (LEUKEMIA, PROMYELOCYTIC, ACUTE).
A characteristic symptom complex.
The science and art of collecting, summarizing, and analyzing data that are subject to random variation. The term is also applied to the data themselves and to the summarization of the data.
Investigative technique commonly used during ELECTROENCEPHALOGRAPHY in which a series of bright light flashes or visual patterns are used to elicit brain activity.

Central peptidergic neurons are hyperactive during collateral sprouting and inhibition of activity suppresses sprouting. (1/6942)

Little is known regarding the effect of chronic changes in neuronal activity on the extent of collateral sprouting by identified CNS neurons. We have investigated the relationship between activity and sprouting in oxytocin (OT) and vasopressin (VP) neurons of the hypothalamic magnocellular neurosecretory system (MNS). Uninjured MNS neurons undergo a robust collateral-sprouting response that restores the axon population of the neural lobe (NL) after a lesion of the contralateral MNS (). Simultaneously, lesioned rats develop chronic urinary hyperosmolality indicative of heightened neurosecretory activity. We therefore tested the hypothesis that sprouting MNS neurons are hyperactive by measuring changes in cell and nuclear diameters, OT and VP mRNA pools, and axonal cytochrome oxidase activity (COX). Each of these measures was significantly elevated during the period of most rapid axonal growth between 1 and 4 weeks after the lesion, confirming that both OT and VP neurons are hyperactive while undergoing collateral sprouting. In a second study the hypothesis that chronic inhibition of neuronal activity would interfere with the sprouting response was tested. Chronic hyponatremia (CH) was induced 3 d before the hypothalamic lesion and sustained for 4 weeks to suppress neurosecretory activity. CH abolished the lesion-induced increases in OT and VP mRNA pools and virtually eliminated measurable COX activity in MNS terminals. Counts of the total number of axon profiles in the NL revealed that CH also prevented axonal sprouting from occurring. These results are consistent with the hypothesis that increased neuronal activity is required for denervation-induced collateral sprouting to occur in the MNS.  (+info)

Retinotopic mapping of lateral geniculate nucleus in humans using functional magnetic resonance imaging. (2/6942)

Subcortical nuclei in the thalamus, which play an important role in many functions of the human brain, provide challenging targets for functional mapping with neuroimaging techniques because of their small sizes and deep locations. In this study, we explore the capability of high-resolution functional magnetic resonance imaging at 4 Tesla for mapping the retinotopic organization in the lateral geniculate nucleus (LGN). Our results show that the hemifield visual stimulation only activates LGN in the contralateral hemisphere, and the lower-field and upper-field visual stimulations activate the superior and inferior portion of LGN, respectively. These results reveal a similar retinotopic organization between the human and nonhuman primate LGN and between LGN and the primary visual cortex. We conclude that high-resolution functional magnetic resonance imaging is capable of functional mapping of suborganizations in small nuclei together with cortical activation. This will have an impact for studying the thalamocortical networks in the human brain.  (+info)

Command-related distribution of regional cerebral blood flow during attempted handgrip. (3/6942)

To localize a central nervous feed-forward mechanism involved in cardiovascular regulation during exercise, brain activation patterns were measured in eight subjects by employing positron emission tomography and oxygen-15-labeled water. Scans were performed at rest and during rhythmic handgrip before and after axillary blockade with bupivacaine. After the blockade, handgrip strength was reduced to 25% (range 0-50%) of control values, whereas handgrip-induced heart rate and blood pressure increases were unaffected (13 +/- 3 beats/min and 12 +/- 5 mmHg, respectively; means +/- SE). Before regional anesthesia, handgrip caused increased activation in the contralateral sensory motor area, the supplementary motor area, and the ipsilateral cerebellum. We found no evidence for changes in the activation pattern due to an interaction between handgrip and regional anesthesia. This was true for both the blocked and unblocked arm. It remains unclear whether the activated areas are responsible for the increase in cardiovascular variables, but neural feedback from the contracting muscles was not necessary for the activation in the mentioned areas during rhythmic handgrip.  (+info)

Language processing is strongly left lateralized in both sexes. Evidence from functional MRI. (4/6942)

Functional MRI (fMRI) was used to examine gender effects on brain activation during a language comprehension task. A large number of subjects (50 women and 50 men) was studied to maximize the statistical power to detect subtle differences between the sexes. To estimate the specificity of findings related to sex differences, parallel analyses were performed on two groups of randomly assigned subjects. Men and women showed very similar, strongly left lateralized activation patterns. Voxel-wise tests for group differences in overall activation patterns demonstrated no significant differences between women and men. In further analyses, group differences were examined by region of interest and by hemisphere. No differences were found between the sexes in lateralization of activity in any region of interest or in intrahemispheric cortical activation patterns. These data argue against substantive differences between men and women in the large-scale neural organization of language processes.  (+info)

Selective horizontal dysmetropsia following prestriate lesion. (5/6942)

We describe a patient (P.S.) who, following a right prestriate lesion, reported that objects in the left visual field appeared distorted and smaller than those on the right. Other aspects of visual processing were remarkably unaffected. We carried out a series of size comparison tests using simple or complex stimuli and requiring different types of behavioural responses. We found that P.S. significantly underestimated the size of stimuli presented in her left visual field. When comparison tasks involved stimuli placed along the vertical axis or in the right visual field, P.S. performed well. The vertical and horizontal components of size distortion were found to be differentially affected. We conclude that size processing may be dissociated from other aspects of visual processing, such as form or colour processing, and depends critically on part of the occipital, prestriate areas (Brodmann areas 18-19).  (+info)

The role of ventral medial wall motor areas in bimanual co-ordination. A combined lesion and activation study. (6/6942)

Two patients with midline tumours and disturbances of bimanual co-ordination as the presenting symptoms were examined. Both reported difficulties whenever the two hands had to act together simultaneously, whereas they had no problems with unimanual dexterity or the use of both hands sequentially. In the first patient the lesion was confined to the cingulate gyrus; in the second it also invaded the corpus callosum and the supplementary motor area. Kinematic analysis of bimanual in-phase and anti-phase movements revealed an impairment of both the temporal adjustment between the hands and the independence of movements between the two hands. A functional imaging study in six volunteers, who performed the same bimanual in-phase and anti-phase tasks, showed strong activations of midline areas including the cingulate and ventral supplementary motor area. The prominent activation of the ventral medial wall motor areas in the volunteers in conjunction with the bimanual co-ordination disorder in the two patients with lesions compromising their function is evidence for their pivotal role in bimanual co-ordination.  (+info)

Multicentre European study of thalamic stimulation in parkinsonian and essential tremor. (7/6942)

OBJECTIVES: Thalamic stimulation has been proposed to treat disabling tremor. The aims of this multicentre study were to evaluate the efficacy and the morbidity of thalamic stimulation in a large number of patients with parkinsonian or essential tremor. METHODS: One hundred and eleven patients were included in the study and 110 were implanted either unilaterally or bilaterally. Patients were evaluated with clinical scales, before and up to 12 months after surgery. RESULTS: Upper and lower limb tremor scores were reduced in both groups. Eighty five per cent of the electrodes satisfied the arbitrary criteria of two point reduction in rest tremor reduction in the parkinsonian tremor group and 89% for postural tremor reduction in the essential tremor group. In the parkinsonian tremor group, limb akinesia and limb rigidity scores were moderately but significantly reduced. Axial scores were unchanged. In the essential tremor group, head tremor was significantly reduced only at 3 months and voice tremor was non-significantly reduced. Activities of daily living were improved in both groups. Changes in medication were moderate. Adverse effects related to the surgery were mild and reversible. CONCLUSIONS: Thalamic stimulation was shown to be an effective and relatively safe treatment for disabling tremor. This procedure initially applied in a very limited number of centres has been successfully used in 13 participating centres.  (+info)

Cognitive outcome after unilateral pallidal stimulation in Parkinson's disease. (8/6942)

OBJECTIVES: Chronic high frequency electrostimulation of the globus pallidus internus mimics pallidotomy and improves clinical symptoms in Parkinson's disease. The aim of this study was to investigate the cognitive consequences of unilateral deep brain stimulation. METHODS: Twenty non-demented patients with Parkinson's disease (age range 38-70 years) were neuropsychologically assessed 2 months before and 3 months after unilateral pallidal stimulation. The cognitive assessment included measures of memory, spatial behaviour, and executive and psychomotor function. In addition to group analysis of cognitive change, a cognitive impairment index (CII) was calculated for each individual patient representing the percentage of cognitive measures that fell more than 1 SD below the mean of a corresponding normative sample. RESULTS: Neurological assessment with the Hoehn and Yahr scale and the unified Parkinson's disease rating scale disclosed a significant postoperative reduction in average clinical Parkinson's disease symptomatology (p<0.001). Repeated measures multivariate analysis of variance (using right/left side of stimulation as a between subjects factor) showed no significant postoperative change in cognitive performance for the total patient group (main effect of operation). The side of stimulation did not show a significant differential effect on cognitive performance (main effect of lateralisation). There was no significant operation by lateralisation interaction effect. Although the patients experienced significant motor symptom relief after pallidal stimulation, they remained mildly depressed after surgery. Analysis of the individual CII changes showed a postoperative cognitive decline in 30% of the patients. These patients were significantly older and took higher preoperative doses of levodopa than patients showing no change or a postoperative cognitive improvement. CONCLUSIONS: Left or right pallidal stimulation for the relief of motor symptoms in Parkinson's disease seems relatively safe, although older patients and patients needing high preoperative doses of levodopa seem to be more vulnerable for cognitive decline after deep brain stimulation.  (+info)

All information about the latest scientific publications of the Clínica Universidad de Navarra. Functional cerebral lateralization: neurobiology and clinical aspects in childhood
So what can the mind show about handedness? One in every of the first scientists to ponder the mystery of left-handedness became pioneering French surgeon Paul Broca, whom Wolman calls the closest aspect the religion of Southpaw has to a prophet. In 1861, accurate two years after Darwin had came all the map in which through the rules of evolution, Broca encountered two patients who stumped him profoundly. One became an epileptic man named Leborgne however is known as Tan, nicknamed after the one syllable he became able to uttering. Leborgne became in a location to love spoken language however couldnt inform his thoughts in speech - something that at a loss for phrases Broca very a lot, doubly so offered that one of Leborgnes first signs became a weakening of feature in the accurate side of his body, which progressed to more loss of motor rob a watch on and at closing the loss of spy and just a few of his mental colleges.. When Leborgne died on the age of 51, Broca made up our minds to ...
I recently read, or rather re-read, Martin Gardners excellent book from the 60s, The Ambidextrous Universe: Left, Right, and the Fall of Parity (1st published in 1964 as The Ambidextrous Universe: Mirror Asymmetry and Time-Reversed Worlds), and this got me thinking as to why left-handedness is comparatively uncommon in human beings and there remains no conclusive answer as to the cause or source of this human phenomenon. In other mammals and in some species of birds, I have been lead to
In most people, language is processed predominantly by the left hemisphere of the brain, but we do not know how or why. A popular view is that developmental language disorders result from a poorly lateralized brain, but until recently, evidence has been weak and indirect. Modern neuroimaging methods have made it possible to study normal and abnormal development of lateralized function in the developing brain and have confirmed links with language and literacy impairments. However, there is little evidence that weak cerebral lateralization has common genetic origins with language and literacy impairments. Our understanding of the association between atypical language lateralization and developmental disorders may benefit if we reconceptualize the nature of cerebral asymmetry to recognize its multidimensionality and consider variation in lateralization over developmental time. Contrary to popular belief, cerebral lateralization may not be a highly heritable, stable characteristic of individuals; rather,
Lateralization of brain structure and function occurs in typical development, and abnormal lateralization is present in various neuropsychiatric disorders. Autism is characterized by a lack of left lateralization in structure and function of regions involved in language, such as Broca and Wernicke areas. Using functional connectivity magnetic resonance imaging from a large publicly available sample (n = 964), we tested whether abnormal functional lateralization in autism exists preferentially in language regions or in a more diffuse pattern across networks of lateralized brain regions. The autism group exhibited significantly reduced left lateralization in a few connections involving language regions and regions from the default mode network, but results were not significant throughout left- and right-lateralized networks. There is a trend that suggests the lack of left lateralization in a connection involving Wernicke area and the posterior cingulate cortex associates with more severe autism. Abnormal
Backe throws at practiceAstros righthander Brandon Backe, on the disabled list with a strained left intercostal muscle, threw two simulated innings of 20 pitches each Saturday in his first major test since early March. Matsui, Keppinger sit outSecond baseman Kazuo Matsui was out of the starting lineup with back stiffness for the fourth consecutive game. Backup infielder Jeff Keppinger also was out of the lineup with the back soreness that forced him out Thursday. Matsui was limited to 96 games last year because of three separate trips to the disabled list, including a stint from Aug. 13 through Sept. 2 with an irritated disc in his back. Arias heads to ExpressThe Astros are set to recall righthander Felipe Paulino so he can start Sunday, so righthander Alberto Arias was optioned back to Class AAA Round Rock three days after he had been recalled. Coming upRHP Felipe Paulino will officially be recalled from Class AAA Round Rock to start Sunday against Cincinnati righthander Edinson Volquez (1-1, 9.64
The Reds have placed right-hander Homer Bailey on the disabled list and promoted fellow right-hander and top prospect Robert Stephenson, the club announced. However, it appears that Stephenson, who rates among the games 35 best minor leaguers (per Baseball America, MLB.com and ESPNs Keith Law) will merely be making a spot start and isnt yet being viewed as a long-term option in the rotation; C. Trent Rosecrans of the Cincinnati Enquirer writes that Stephenson will likely be optioned back to Triple-A following his start, as right-hander Anthony DeSclafani will be ready to come of the DL and join the rotation on April 10. Cincinnati currently has Raisel Iglesias, Brandon Finnegan and Stephenson lined up for their season-opening series against the Phillies, with Alfredo Simon set to start the clubs fourth game of the year. DeSclafani should grab Stephensons spot in the rotations second cycle of the season, and right-hander Jon Moscot should be able to return mid-month - possibly to start on ...
LAKE ELSINORE, Calif. -- Pain free but knocked around on Friday night in his first rehab start, Dodgers right-hander Zack Greinke said hes ready to return to the Major Leagues one month after breaking his left collarbone. But Greinke also said he might not have pitched well enough to convince management hes ready after allowing eight runs (three earned) on six hits in 4 1/3 innings for Class A Rancho Cucamonga against San Diegos Lake Elsinore affiliate. He made 80 pitches and struck out four without a walk.
Throughout history, left-handedness has both fascinated and frightened people. Maybe it is because only about 15 percent of the population is left-handed. Or maybe it is because the reasons for left-handedness remain somewhat of a mystery.. What makes a person left- or right-handed? It seems we can find the answer in our genes, at least partially. Most researchers in the field agree that left- or right-handedness is most likely produced by genetic influences. We inherit our genes from our parents, and the genes that are turned on determine our characteristics. The specific reasons behind these genetic differences are still hotly debated, but many studies seem to point to natural selection as a probable cause.. The human brain is divided into the right and left hemispheres, with nerve fibers connecting the two. Different parts of each half of the brain control different functions of the body. Many evolutionary biologists argue that evolution produced a majority of people who controlled language ...
data frame has 37 rows and 2 columns. The data are from an experiment which was designed to look for a relationship between a certain genetic characteristic and handedness. The 37 subjects were women who had a son with mental retardation due to inheriting a defective X-chromosome. For each such mother a genetic measurement of their DNA was made. Larger values of this measurement are known to be linked to the defective gene and it was hypothesized that larger values might also be linked to a progressive shift away from right-handednesss. Each woman also filled in a questionnaire regarding which hand they used for various tasks. From these questionnaires a measure of hand preference was found for each mother. The scale of this measure goes from 1, indicating someone who always favours their right hand, to 8, indicating someone who always favours their left hand. Between these two extremes are people who favour one hand for some tasks and the other for other tasks. ...
ARL Full Game Coverage INGTON -- The Rangers, with a week to go before the July 31 non-waiver Trade Deadline, are looking for a difference-maker for their rotation, according to industry sources. Thats why Phillies left-hander Cole Hamels and Brewers right-hander Zack Greinke had been at the top of their list. The Rangers had discussions with both teams as well as any other team that has starting pitching to trade before next Tuesday. The Rangers have also scouted Marlins right-hander Josh Johnson. The Rangers have a rotation that includes left-handers Derek Holland and Matt Harrison and right-hander Yu Darvish. They lost Colby Lewis for the season with a torn flexor tendon in his right elbow, but are expecting Roy Oswalt to return to the rotation on Sunday after skipping a start with tightness in his lower back. Scott Feldman beat the Red Sox, 9-1, on Tuesday
DETROIT - Triple-A Rochester right-hander Liam Hendriks, coming off eight shutout innings Monday, will return to the Twins rotation Saturday in Cleveland. Hendriks will take the place of fellow right-hander Kyle Gibson, demoted Monday after going 2-4 with a 6.53 earned-run average in 10 big-league starts. Gibson will be slotted back into Rochesters rotation in Sundays home game against Indianapolis. Gibson will piggyback with veteran right-hander Virgil Vasquez, allowing the Twins to better control his workload. The highly regarded prospect has pitched 143 2/3 innings in 25 combined starts at Rochester and with the Twins. Somewhere between 150 and 160 innings remains a logical stopping point for Gibson as he approaches the two-year anniversary of his Tommy John surgery on Sept. 7. Hendriks, meanwhile, gave the Twins an excellent spot start Aug. 9 at Chicago in the second game of a doubleheader. The bubbly Australian went 6 1/3 innings against the White Sox, allowing two runs on a pair of ...
Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated whether strongly lateralized connections covaried within the same individuals. Data were analyzed from publicly available resting state scans for 1011 individuals between the ages of 7 and 29. For each subject, functional lateralization was measured for each pair of 7266 regions covering the gray matter at 5-mm resolution as a difference in correlation before and after inverting images across the midsagittal plane. The difference in gray matter density between homotopic coordinates was used as a regressor to reduce the effect of structural asymmetries on functional lateralization. Nine left- and 11 ...
Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated whether strongly lateralized connections covaried within the same individuals. Data were analyzed from publicly available resting state scans for 1011 individuals between the ages of 7 and 29. For each subject, functional lateralization was measured for each pair of 7266 regions covering the gray matter at 5-mm resolution as a difference in correlation before and after inverting images across the midsagittal plane. The difference in gray matter density between homotopic coordinates was used as a regressor to reduce the effect of structural asymmetries on functional lateralization. Nine left- and 11 ...
In an earlier study, Dellatolas, Curt and Lellouch (1991) concluded that handedness is not related to season of birth. However, post-hoc exploration of their and other sets of data has shown that there is an apparent tendency for left-handedness to be more prevalent in the period March-July than in the period August-February. The present work tested this seasonal hypothesis prospectively among university students. It was found that the proportion of all left-handed participants who were born in the period March-July was indeed significantly greater than the proportion of all right-handed participants who were born in the same period. Furthermore, the pattern of seasonal influence upon handedness did not vary significantly between females and males. The relation between handedness and season of birth may be linked to seasonal variation in other factors such as the incidence of infectious agents.
TY - JOUR. T1 - Mapping hemispheric asymmetries of the macaque cerebral cortex during early brain development. AU - Xia, Jing. AU - Wang, Fan. AU - Wu, Zhengwang. AU - Wang, Li. AU - Zhang, Caiming. AU - Shen, Dinggang. AU - Li, Gang. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Studying cortical hemispheric asymmetries during the dynamic early postnatal stages in macaque monkeys (with close phylogenetic relationship to humans) would increase our limited understanding on the possible origins, developmental trajectories, and evolutional mechanisms of brain asymmetries in nonhuman primates, but remains a blind spot to the community. Via cortical surface-based morphometry, we comprehensively analyze hemispheric structural asymmetries in 134 longitudinal MRI scans from birth to 20 months of age from 32 healthy macaque monkeys. We reveal that most clusters of hemispheric asymmetries of cortical properties, such as surface area, cortical thickness, sulcal depth, and vertex positions, expand in the first 4 ...
The transfer of a skill learned in one hand to the other hand has been used as evidence for the role of the brains hemispheres in controlling that skill. The movement of knowledge from the dominant to the nondominant arm (D ->ND) has been interpreted as confirmation of the brains ability to encode an experience in the dominant hemisphere with the dominant hand and to influence the performance of the nondominant hand. Many researchers believe that this process is accomplished either through connections across both hemispheres or through the same side of the brain. Other scientists believe that transfer in the opposite direction reflects a dominance of the right hemisphere (in right-handers) for some aspects of motor control, so both directions of transfer can be explained with a single model ...
EVANSTON, Ill. --- Lefties have always been a bit of a puzzle. Representing only 10 percent of the general human population, left-handers have been viewed with suspicion and persecuted across history. The word sinister even derives from left or left-hand.. Two Northwestern University researchers now report that a high degree of cooperation, not something odd or sinister, plays a key role in the rarity of left-handedness. They developed a mathematical model that shows the low percentage of lefties is a result of the balance between cooperation and competition in human evolution.. Professor Daniel M. Abrams and his graduate student Mark J. Panaggio -- both right-handers -- are the first to use real-world data (from competitive sports) to test and confirm the hypothesis that social behavior is related to population-level handedness.. The results are published today (April 25) in The Journal of the Royal Society Interface.. The more social the animal -- where cooperation is highly valued -- the ...
More worrying, because mysterious, in my handiwork life was the way nothing I cut or measured, no matter how carefully, ever came out the right size. In woodwork the length of the strut for the bookshelf was always too short, and so had to be discarded, or too long, so Id measure again and cut a bit off, still too long, and so on until finally it was too short and had to be thrown away. The front and back of a blouse never matched. Other people got it right first time and there was no explaining it. Left-handedness might have been part of the problem. I was always using the wrong tools. Saws were hopeless, as bread knives and scissors still are; bread, paper and timber end up cut on a slant, no matter how hard I try. Pen nibs were cut for right-handers, indeed left-to-right writing is designed for them, so that my wrist was always smudging the already blotty letters. Sewing machines had the knobs and bobbin things on the back if I used them. But no one mentioned that and so I couldnt ...
List of 131 causes for Acute Alzheimers-like memory loss and Alzheimers-like memory loss and Bilateral brain hemisphere damage and Epilepsy, alternative diagnoses, rare causes, misdiagnoses, patient stories, and much more.
In the present study we investigate age-related changes in hand preference for grasping and the influence of task demands on such preference. Children (2-11), young-adults (17-28) and older-adults (57-90) were examined in a grasp-to-eat and a grasp-to-construct task. The end-goal of these tasks was different (eat versus construct) as was the nature of the task (unimanual versus bimanual). In both tasks, ipsilateral and contralateral grasps were analyzed. Results showed a right-hand preference that did not change with age. Across the three age groups, a more robust right-hand preference was observed for the unimanual, grasp-to-eat task. To disentangle if the nature (unimanual) or the end-goal (grasp-to-eat) was the driver of the robust right-hand preference, a follow up experiment was conducted. Young-adult participants completed a unimanual grasp-to-place task. This was contrasted with the unimanual grasp-to-eat task and the bimanual grasp-to-construct task. Rates of hand preference for the grasp-to-eat
PITTSBURGH -- Right-hander Brandon Morrow will miss at least two months because of a torn tendon sheath in his right index finger.. Morrow sustained the injury during the fifth inning of Friday nights loss to the Pirates. He finished the inning but did not come back out for the sixth, and he then flew to Florida on Saturday morning for an MRI exam.. The test revealed a tear, and as a result Morrow has been placed on the 60-day disabled list. The hope is that Morrow will be able to avoid surgery and return in July, but there is also a chance he will not pitch again this season. The Blue Jays recalled right-hander Chad Jenkins to take Morrows spot on the 25-man roster.. If he heals up, he should be back in July; if its not healing up, then theyll have to do surgery and hell be done for the year probably, Blue Jays manager John Gibbons said. Theyre going to wait to see [about] rehab, see if it heals on its own. But if it looks like its not going to [heal], they have the option to have ...
BALTIMORE -- The Twins bullpen is one short on Saturday, after Samuel Deduno was claimed off waivers by the Houston Astros.. The 31-year-old righthander, who twice failed to hold a spot in Minnesotas starting rotation, finishes his Twins career with a 16-18 record and 4.26 ERA. He started 41 games, pitched in long relief another 22 times, and tantalized fans with his sometimes-dominating fastball.. But his lack of control was a persistent problem, and ultimately, the Twins decided to let him go for nothing but the $25,000 waiver fee. The Astros will pay the final month of his $520,000 contract, and the Twins free up a roster spot they can use for a younger player.. He was sad to leave Minnesota, said manager Ron Gardenhire, who broke the news to the veteran righthander in the lobby of the teams hotel here. He definitely liked it here. But I told him, its always a good thing when somebody wants you.. To replace Deduno, the Twins added lefthander Aaron Thompson to the 40-man roster and ...
I am happy here. This is where I want to stay, De La Rosa said.. There was little movement in the division. Arizona acquired left-handed reliever Joe Thatcher from San Diego, parting with starter Ian Kennedy. The Dodgers signed free-agent reliever Brian Wilson on Tuesday. The biggest trades involved the Red Sox landing White Sox right-hander Jake Peavy and the Orioles acquiring right-hander Bud Norris from the Astros.. Its still possible the Rockies could make some roster wrinkles. Several teams were interested in closer Rafael Betancourt before his appendectomy. However, a player must pass through waivers this month to be traded. And other teams can block that move, leaving the player typically pulled back rather than a deal getting worked out.. Bettis arrives. Rookie Chad Bettis doesnt scare easily. Good thing. Hes up next, making his major-league debut Thursday. The Rockies starters have allowed 30 hits and 20 earned runs in the first three games of this series.. Colorado has been ...
Ex-Yankee Phil Hughes is expected to receive $24 million for three years from the Twins, who are also making progress to bring back A.J. Pierzynski.
SAN DIEGO (AP) - Right-hander Bartolo Colon was designated for assignment by the Atlanta Braves on Thursday, one day after the 44-year-old right-handers record dropped to 2-8.
The St. Louis Cardinals will turn to veteran right-hander Adam Wainwright as they look to extend their winning streak and continue their playoff push by completing a four-game road sweep of the division-leading Milwaukee Brewers on Thursday afternoon.. Wainwright (16-7, 2.89 ERA) will be opposed by right-hander Adrian Houser (9-6, 3.43), who has won both starts this season against St. Louis without allowing an earned run in 14 innings.. The Cardinals pounded out 15 hits to push their winning streak to a season-high 11 games with a 10-2 victory over the Brewers on Wednesday night.. MORE ...
Hemispheric differences for visual P3 amplitude in patients with schizophrenia, Pegah Vafaii, Shahrzad Mazhari, Ali Mohammad Pourrahimi, Nouzar Nakhaee
One challenge to modelling population-level handedness is a lack of data for empirical validation. To quote Ghirlanda et al. … we need data from populations that differ in the balance between antagonistic and synergistic interactions but are otherwise as similar as possible [11]. Ideally, we would compare predicted equilibria of equation (2.2) to data from animal populations exhibiting varying degrees of cooperation. Unfortunately, for most species, quantifying the degree of cooperation is difficult, and the available data on the degree and direction of population-level lateralization vary from experiment to experiment depending on the task considered. This lack of consistent, conclusive data on handedness in the natural world leads us to examine the proxy situation of athletics (as done in Raymond et al. [1]), where data on handedness and cooperation are more easily accessible.. To explain the observed fraction of left-handed athletes, it is important to model the selection process because ...
00New Perspectives on Language and Sexual Identity by Morrish, E. HcoverNew Perspectives on Language and Sexual Identity causes a download Cerebral Asymmetries in Sensory to the including student of smoothie and government. not your download Cerebral Asymmetries in Sensory and Perceptual Processing 1997 would investigate remained built to he. whole Dynamic Interplay Between Context and the Language Learner by King, JimBy King, Jim.
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The Left-Hander Syndrome: The Causes and Consequences of Left-handedness by Stanley Coren, John Murray, pp 308, Pounds sterling 16.95 Perhaps the least noticed and most disadvantaged minority group is the left-handed. Their bad press goes back to ancient times. After all, (God) set the sheep on his right hand, and the goats on the left …
People who are highly creative have better connectivity between the left and right brain hemispheres, according to a new study by a team of international researchers.
Results Techniques were first established in controls. Lower limb TT-TMS normal values (n=35) showed no statistically significant difference from upper limb (11.5+1.2 vs 11.3+1.1) and no significant interhemispheric differences (p=0.8). Novel testing of all 4-limbs in patients revealed differences in the pattern and spread of UMN and LMN vulnerability. Peripheral DTI metrics identified early axonal degeneration in the pre-symptomatic upper limb, correlating with clinical and neurophysiological markers of disease progression. Cortical hyperexcitability was associated with the clinically symptomatic limb as well site of onset in all phenotypes. In upper limb onset patients, clinical asymmetry correlated with synchronous asymmetry in LMN and UMN involvement, with significant interhemispheric differences in cortical hyperexcitability (p=0.05). ...
The involvement of the right and left hemispheres in mediating language functions has been measured in a variety of ways over the centuries since the relative dominance of the left hemisphere was first known. Functional magnetic resonance imaging (fMRI) presents a useful non-invasive method of assessing lateralisation that is being increasingly used in clinical practice and research. However, the methods used in the fMRI laterality literature currently are highly variable, making systematic comparisons across studies difficult. Here we consider the different methods of quantifying and classifying laterality that have been used in fMRI studies since 2000, with the aim of determining which give the most robust and reliable measurement. Recommendations are made with a view to informing future research to increase standardisation in fMRI laterality protocols. In particular, the findings reinforce the importance of threshold-independent methods for calculating laterality indices, and the benefits of
How did life originate and why were left-handed molecules selected for its architecture? This question of high public and interdisciplinary scientific interest is the central theme of this book. It is widely known that in processes triggering the origin of life on Earth, the equal occurrence, the parity between left-handed amino acids and their right-handed mirror images, was violated. The balance was inevitably tipped to the left - as a result of which lifes proteins today exclusively implement the left form of amino acids. Written in an engaging style, this book describes how the basic building blocks of life, the amino acids, formed. After a comprehensible introduction to stereochemistry, the author addresses the inherent property of amino acids in living organisms, namely the preference for left-handedness. What was the cause for the violation of parity of amino acids in the emergence of life on Earth? All the fascinating models proposed by physicists, chemists and biologist are vividly
Ive been trying to make it work. Its been trying to avoid working for me. Were at a standoff. However, here are my insights about it, which you may translate easily into left-handedness: what youre actually doing is wrapping the yarn around and around your hand. The whole deal with the finger is just to make sure that you can take the wrapped yarn OFF again - cause if youd just wrap yarn around your hand, it would, uh, be nice a nice and tight - but not plyable-from - hand warmer. So, the trick youre trying to do is to insert a something (your middle finger) into the tight ball being wrapped, and then remove it, so that the tight ball has a large enough center hole to fit comfortably and nicely over your wrist, without pain. Ive been experimenting with toilet rolls instead of hands (for making the center-pull ball - which seems to entail mostly just the keeping track of where the first end, while simultaneously rolling the ball with the business end; I do that by sticking the first end ...
Peter Tatchell, an Australian-born British homosexual activist who founded the direct action group OutRage! that specialises in media stunts such as disrupting Christian religious services, wrote on Spiked Online that he agrees with the scientific consensus that there is no such thing as a gay gene. Contrary to the findings of some researchers who have tried to posit a purely genetic origin for same-sex attractions, Tatchell wrote, Genes and hormones may predispose a person to one sexuality rather than another. But thats all. Predisposition and determination are two different things.. Homosexual activists have adopted the gay gene theory to bolster their assertion that any objection on moral grounds to homosexual activity is akin to objecting to left-handedness or skin colour. It has supported the accusation that Christians and others who object to the homosexual movement are racists and bigots. Tatchell even went as far as to acknowledge the existence of some who have changed their ...
The brain is usually associated with the thinking process, memory, cognition, logic or concentration. However, the real mechanism of action of this highly-evolved structure might leave you amazed. Let us take the lateralization of brain function. As discussed before, there are two distinct cerebral halves separated by a median fissure.. Studies show that each human being evolves in his own manner and has his own unique lateralization. The left hemisphere is associated with action and strongly related to emotional impulses that can lead to risky behaviors or unwise decisions. The manner of speech and muscular movement seem to be more dominant in this case. The right hemisphere on the other hand is connected to logical thinking and visuospatial attention. According to a study published in 2013, left hemisphere regions tend to interact with the same hemisphere, while right-hemisphere constituents are likely to do so with both halves. Still, their functions remain largely related. For example, if a ...
Assume that left-handedness is a recessive trait controlled by one pair of dominant-recessive alleles. If 625 of 2,500 individuals in a sample of a population is left-handed, and if the population is in Hardy-Weinberg.
Split-brain research has been conducted for decades, and scientists have long ago shown that language processing is largely located in the left side of the brain. When words appear only in the left visual field -- an area processed by the right side of the brain -- the right brain must transfer that information to the left brain, in order to interpret it. The new study at UCSB shows that healthy test subjects respond less accurately when information is shown only to the right brain. While hemispheric specialization is considered accurate, the new study sheds light on the highly complex interplay -- with neurons firing back and forth between distinct areas in each half of the brain.This study shows that the strength of communication across the brain changes dynamically, when information is exchanged between the right and left hemispheres via the corpus callosum, which connects both sides of the brain. ...
While the left hemispheric role in speech production has been extensively studied the role of the right hemisphere is less explored. Therefore, this paper addressed the question to what extend the right hemisphere is involved in prosodic production in an intonational language such as German. In particular, we explored the speech production of three patients with right hemisphere damage and compared these data to that of matched controls. We used a question-answer test of 48 German sentences with different verb-argument structures and varying focus positions. Healthy subjects correctly differentiated between the syntactic conditions and between the wide and narrow focused sentences by correlating prosodic parameters with cues for Intonational Phrasing as well as for accent distribution and accent types. In comparison, patients had difficulties in realizing prominence/accent distribution. Additionally, they seem to have a decreasing capacity for durational control as indicated by missing prefinal ...
New York, NY - September 14, 2000 - Columbia-Presbyterian researchers report that rather than being completely hard wired, structures on one side of the brain can take over certain language functions normally achieved by a damaged region on the opposite side. The study, published in the September 2000 issue of the journal Neuropsychologia, may provide insights into the brains compensatory responses to injury.. The brain is not a homogeneous structure-various brain functions are each performed by distinct, areas, so damage to a brain region can produce a specific and lasting functional difficulty in perception, thinking, or movement. Columbia-Presbyterian researchers report, however, that in the brains of three patients with chronic arteriovenous malformations (AVMs) in the left frontal lobe, brain functions involved in speech production were successfully relocated.. AVMs are chronic conditions thought to begin developing in utero and may begin causing brain problems, as evidenced by ...
Results TMS data revealed 12/13 subjects had asymmetric motor representation (lateralised dominance) for the pharynx (6 left, 6 right) with significantly larger responses observed in the lateralised projection (p , 0.001). FMRI data (figure 1) also revealed asymmetric activations in both sensorimotor cortices in each subject for the different tasks which were used as seed regions for tractography. Largest activations were observed in primary motor cortices (Brodmann Area (BA) 4) after water swallowing, predominantly right lateralised. By contrast, tongue elevation and saliva swallowing produced a greater number of left lateralised brain areas, particularly pre- and supplementary-motor cortex (BA 6) as well as areas involved with language and speech processing (BA 22,40,44). Tractography revealed larger tract volumes in the hemispheric dominant projection predicted by TMS compared to the non-dominant projection for water but not for saliva swallowing or tongue elevations (p , 0.001 ...
Results TMS data revealed 12/13 subjects had asymmetric motor representation (lateralised dominance) for the pharynx (6 left, 6 right) with significantly larger responses observed in the lateralised projection (p , 0.001). FMRI data (figure 1) also revealed asymmetric activations in both sensorimotor cortices in each subject for the different tasks which were used as seed regions for tractography. Largest activations were observed in primary motor cortices (Brodmann Area (BA) 4) after water swallowing, predominantly right lateralised. By contrast, tongue elevation and saliva swallowing produced a greater number of left lateralised brain areas, particularly pre- and supplementary-motor cortex (BA 6) as well as areas involved with language and speech processing (BA 22,40,44). Tractography revealed larger tract volumes in the hemispheric dominant projection predicted by TMS compared to the non-dominant projection for water but not for saliva swallowing or tongue elevations (p , 0.001 ...
This volume explores both simple and sophisticated techniques used in the study of different types of lateralization of brain and behavior. Research in this field increases our understanding of variou
Human brain hemispheres are asymmetric. Individual anatomical differences involve widespread cortical and subcortical areas and are more prominent among males [1,2]. The interhemispheric asymmetry is...
We present a description of a new software package, dopOSCCI, which summarises data from experimental studies where functional transcranial Doppler ultrasonography (fTCD) is used to compare hemispheric rates of blood flow in order to assess lateralization of a cognitive process. The software provides a graphical user interface to summarise analogue and digital data collected using Multi-Dop Doppler Ultrasound devices (DWL Multidop T2: manufacturer, DWL Elektronische Systeme, Singen, Germany). The unique aspects of dopOSCCI allow multi-file processing, multi-event marker processing, behavioural and multi-session summaries, image file data visualization, and tab-delimited output files which includes split-half, single-trial summaries and data quality variables. The Matlab based software is available under the GNU GPL license and can be accessed online at https://databank.ora.ox.ac.uk/general/datasets/dopOSCCI, the Oxford University DataBank.
American Journal of Primatology 70:254-260 (2008) RESEARCH ARTICLE Consistency of Hand Preference Across Low-level and High-level Tasks in Capuchin Monkeys (Cebus apella) ALAYNA L. LILAK AND KIMBERLEY A. PHILLIPS Department of Psychology, Hiram College, Hiram, Ohio Numerous studies investigating behavioral lateralization in capuchins have been published. Although some research groups have reported a population-level hand preference, other researchers have argued that capuchins do not show hand preference at the population level. As task complexity influences the expression of handedness in other primate species, the purpose of this study was to collect hand preference data across a variety of high- and low-level tasks to evaluate how task complexity influences the expression of hand preference in capuchins. We tested eleven captive brown capuchin monkeys (Cebus apella) to determine if they show consistent hand preferences across multiple high- and lowlevel tasks. Capuchins were expected to ...
An new review related to schizophrenia and left handedness covers the changes to the structure of the brain, including which part of the brain deals with which functions have often been thought to be important in schizophrenia. Several studies have noted a higher rate of left-handedness in schizophrenic people although some scientists think this is due to ambidextrousness rather than genuine left-handedness. A recent review of 40 studies into handedness and schizophrenia found that schizophrenic people were more likely to be left-handed although there was often a lack of consistency about the way in which handedness was defined.. Dragovic, M., Hammond, G. - Handedness in schizophrenia : a quantitative review of evidence Acta Psychiatrica Scandinavica June 2005, 111 (6), 410-419. Blog Source: Mental Health Update. ...
Traditionally, anatomical and physiological descriptions of hemispheric specialization have focused on hemispheric asymmetries of local brain structure or local functional properties, respectively. This article reviews the current state of an alternative approach that aims at unraveling the causes and functional principles of hemispheric specialization in terms of asymmetries in connectivity. Starting with an overview of the historical origins of the concept of lateralization, we briefly review recent evidence from anatomical and developmental studies that asymmetries in structural connectivity may be a critical factor shaping hemispheric specialization. These differences in anatomical connectivity, which are found both at the intra- and inter-regional level, are likely to form the structural substrate of different functional principles of information processing in the two hemispheres. The main goal of this article is to describe how these functional principles can be characterized using ...
Background: Most neuroimaging studies investigating language in autism group-match participants with autism and typically developing controls on qualitative handedness of right or left. Evidence suggests, however, that the relationship between handedness and language lateralization may be quite different in autism versus in typical development. Lack of similar relationship between handedness and language lateralization in autism and control groups could affect the results of studies that simply control for handedness. Objectives: The primary objective of the study was to examine the relationship between language lateralization and handedness in autism in comparison to typical development. Methods: Forty-six males with autism and thirty-six typically developing control males, ages 9 to 42 years, were presented with an auditory language task during fMRI. The task required participants to think of a word in response to recorded, spoken phrases, such as the water that falls from the sky or the ...
The use of intracarotid propofol procedure (IPP) when assessing musical lateralization has not been reported in literature up to now. This procedure (similar to Wada Test) has provided the opportunity to investigate not only lateralization of language and memory functions on epileptic patients but also offers a functional mapping approach with superior spatial and temporal resolution to analyze the lateralization of musical abilities. Findings in literature suggest that musical training modifies functional and structural brain organization. We studied hemispheric lateralization in a professional musician, a 33 years old woman with refractory left medial temporal lobe epilepsy. A longitudinal neuropsychological study was performed over a period of 21 months. Before epilepsy surgery, musical abilities, language and memory were tested during IPP by means of a novel and exhaustive neuropsychological battery focusing on the processing of music. We used a selection of stimuli to analyze listening, score
Sensory strength-duration curves were obtained using percutaneous true square-wave pulses ranging from 0.1 to 20.0 ms produced by an isolated constant current stimulator. In 119 healthy volunteers sensory thresholds were measured bilaterally by stimulating the distal phalange of the little finger. In order to examine the relationship of sensory threshold and handedness the latter was assessed by means of the Edinburgh Inventory. An asymmetry of sensory threshold was found for all the subjects and this was more pronounced with shorter stimuli. Of right-handers tested 73.5% had a lower threshold on the left side while 70.8% of left-handers had a lower threshold on the right side. Although threshold asymmetry is associated with handedness this is not necessarily due to cerebral lateralization.. ...
California researchers examined 72 pairs of identical twins, who share all of the same genes, and 67 pairs of fraternal twins, who share many but not all genes. All were World War II veterans enrolled in a long-term government brain study, and their average age was 72. All patients underwent MRI scans to compare the sizes of the left and right sides of their brains. The scans indicated that righties had less symmetrical brains than the lefties, as has been shown in previous research, Dr. Daniel Geschwind and colleagues report in the March 5th issue of the Proceedings of the National Academy of Sciences. And when the researchers compared individual pairs of identical and fraternal twins, they found that the brains of the right-handed identical siblings were the most similar structurally, suggesting a strong genetic underpinning to right-handedness that does not seem to be present for left-handedness. The brain structure differences in right-handers seem to have a significant genetic component, ...
Marlins acquire Prado from Yankees to replace SF-bound McGehee. The Miami Marlins on Tuesday acquired Martin Prado, right-hander David Phelps and cash from the New York Yankees in exchange for right-hander Nathan Eovaldi, first baseman Garrett Jones and right-hander Domingo German.. ...
When 60 percent of the voting public in Ireland voted to redefine marriage, the gaysters screamed with wild euphoria. They were finally being recognized
There are a few differences between the functions of the left and right hemispheres of the brain. One hemisphere is referred to as the dominant hemisphere, and it is most associated with language and with logical skills.2 The areas of the brain that control speech and mathematical abilities are located in the dominant hemisphere.. The non-dominant hemisphere is responsible for creativity, including art and imagination.3 The non-dominant hemisphere is also responsible for integrating spatial information and for controlling a sense of awareness of 3-dimensional space.. The dominant hemisphere of the brain is usually the hemisphere opposite your dominant hand.4 For right-handed individuals, the dominant hemisphere is typically on the left side. For left-handed individuals, the dominant hemisphere may be on the right side, and this is why strokes affect left-handed people differently than they affect right-handed people.5. ...
The Left Brain Right Brain game series is designed to equally train a players weak and dominant hands via logic-based mini-games that require players to rotate the DS in book style play. In Left Brain Right Brain 2, players use the Touch Screen in 20 new games based on speed, accuracy, association, recognition, memory and strategy. Games like Balloon Attack, Block Buster, Cosmic Seesaw and Space Escape, among others, strengthen the left and right hemispheres of the brain by making players switch hands throughout play. Afterwards, players can monitor personal progress and assess improvement by reviewing development percentages for each hand. Gamers can also tailor their favorite mental-training routine in the new Exercises mode, while testing good and weak hands via three random games in Ambidexterity Check. Finally, players can compete with a friend in both single and multi-card multiplayer mode to prove who has the mental skills to be truly ambidextrous ...
Almost all right-handers are left hemisphere dominant (99-ish percent) but with left-handers its about 50/50. Im somewhat ambidextrous, though (prefer right hand but can use left hand even to write), and I tend to be highly logical and very language oriented, spatial orientation skills suck (a right hemisphere skill) but I can sing and play piano as well as draw fairly well. Ive also done some pretty good sculptures...Ive had some abbreviated neuropsychological testing about 10-15 years ago and they thought I had mixed dominance ...
NEW YORK -- Wade LeBlanc said that when he learned he had been claimed off waivers from the Angels on Tuesday, a smile spread across his face. For the 29-year-old left-hander, it was hearing the word Yankees that made him happiest.. Youre ecstatic, LeBlanc said. When I thought about my career path, I never associated it with the New York Yankees, so this is definitely beyond excitement.. LeBlanc joined the Yankees bullpen on Wednesday and will serve as a long reliever, replacing Alfredo Aceves, who was designated for assignment. LeBlanc had been with Triple-A Salt Lake in the Halos system, where he was 5-1 with a 3.69 ERA in nine starts.. The Yankees also recalled right-hander Jose Ramirez from Triple-A Scranton/Wilkes-Barre on Wednesday, optioning right-hander Preston Claiborne to Triple-A.. Yankees manager Joe Girardi said that he will use Ramirez as a multiple-innings pitcher, similar to how he has been using Adam Warren. Ramirez was 2-0 with a save and an 0.84 ERA in seven ...
Handedness is marked by the preference of one hand over another for fine motor tasks, especially writing. Usually, only one hand is considered dominant; however, there are individuals who exhibit the ability to use both hands equally (mixed-handers). The aim of this study was to identify the incidence for handedness in a sample of Greek adolescents and examine possible gender differences in handedness among these adolescents and their siblings. 634 secondary school students (Mean age 13.38, SD = 1.47) who attended mainstream public schools participated in this study. All students completed the Edinburgh Handedness Inventory (EHI). Students were divided in three groups, namely right-handers (an EHI +50 to +100), mixed-handers (an EHI -49 to +49) and left-handers (an EHI -100 to -50). This process resulted in the classification of 544 adolescents (85.8%) as right-handed, 46 adolescents (7.3%) as left-handed and 44 adolescents (6.9%) as non-lateralized (ambidextrous). Contrary to previous research, the
Comments: Until a sprained ulnar collateral ligament sidelined him for his senior season, it appeared Giolito had a legitimate shot at becoming the first high school right-hander in Draft history to go No. 1 overall.Getting comps to Roy Halladay, in terms of his size, Giolito has been projected to have three above-average to plus offerings at his disposal at the next level. While his fastball sits comfortably in the 93-mph range, he was able to reach back and crank it up to 96 mph when needed. Its a heavy fastball that has some very good late movement, and his downhill plane makes it even tougher. Giolito throws a power curve with a sharp break as it reaches the plate. He also has an excellent changeup that dips like a split-fingered pitch. Hes got above-average command of all three, keeping his pitches down in the strike zone to go along with above-average mound presence and competitiveness.The SoCal right-hander wasnt viewed as having any real weaknesses, and, unlike many prep pitchers, it ...
BALTIMORE - The writing was on the wall for the Orioles after starting pitcher Jake Arrietas early struggles made it apparent he wasnt going to stick in Baltimore.. As was the case for large portions of last season, the rotation carousel is in full motion as right-hander Josh Stinson was the first to receive an opportunity just a few weeks after being claimed off waivers from the Oakland Athletics. The 25-year-old had gone through that process two other times in the last year, giving off the impression that hes talented enough to want but not good enough to keep for the long haul.. Manager Buck Showalter chose Stinson over other candidates Zach Britton and Freddy Garcia - citing positive reviews from Triple-A Norfolk manager Ron Johnson and Tides pitching coach Mike Griffin - and was asked whether this was a one-shot opportunity for the right-hander or if he would receive an extended look spanning a few starts. The Baltimore skippers response was familiar, especially when remembering the ...
The As re-signed right-hander starter Bartolo Colon, who was suspended for using performance-enhancing substances in August, to a one-year deal. Despite Colons age and his suspension, the As will pay him $3 million next year, and an incentives package could push the deal to between $5 million and $6 million - including provisions in the event that Colon pitches in relief. The As have not shown objections to signing players serving drug suspensions, adding Manny Ramirez on a minor-league deal last season after his second steroid bust. The As continue to have interest in their other free-agent starter, right-hander Brandon McCarthy, Beane said, and Saturdays transaction will not impact the teams efforts to bring him back. Pitching depth is something Oakland has emphasized the past few years, and Colon, McCarthy, Brett Anderson and A.J. Griffin all were on the disabled list at various points in 2012.
The As appeared to pace themselves, too, relying on a fine start by right-hander Mike Oquist and two innings of strong relief by Bill Taylor to carry them to the 11th inning of a 1-1 game. [...] former As outfielder Shane Mack -- one week removed from his trade to Kansas City -- came back to haunt them in the 12th by scoring on a bases loaded single by Johnny Damon in a 4-1 Royals victory. Seemingly worn-out after Thursday nights 12-run, four-homer eruption, the As quietly settled into abeyance against Royals right-hander Hipolito Pichardo, making him look downright nasty by submitting to five strikeouts. Macfarlane reached second when Royals reliever Scott Service, the one-time Giants pitcher, walked Spiezio and Jason McDonald to load the bases with two out. Macfarlane got his third start for the As when rookie catcher A. J. Hinch was delegated to the dugout last night after being knocked in the head by a popup in the sixth inning of Thursday nights 12-7 victory.
OAKLAND - The Giants spent two months charging to the front of the NL West. Now they are limping to the All-Star break. And the limp is becoming more pronounced by the day.. The Giants officially placed second baseman Joe Panik on the 7-day disabled list with what Manager Bruce Bochy termed a mild concussion.. The club purchased the contract of former Mets and Cardinals infielder Ruben Tejada, who is in Wednesdays lineup at third base as the Bay Bridge series shifts to the Coliseum for the final two games.. Panik joins third baseman Matt Duffy, outfielder Hunter Pence, infielder Kelby Tomlinson, infielder Ehire Adrianza, right-hander Matt Cain and right-hander Sergio Romo on the disabled list.. The Giants had signed Tejada to a minor league contract just two weeks ago after the St. Louis Cardinals had cut him loose. He was batting .205 with one home run in 11 games for Triple-A Sacrament0.. With Ramiro Peña and Brandon Crawford the only middle infielders on the active roster, and no other ...
HUMAN NEUROSCIENCE. ORIGINAL RESEARCH ARTICLE. published: 09 February 2015 doi: 10.3389/fnhum.2015.00055. Hemispheric differences in relational reasoning: novel insights based on an old technique. Michael S. Vendetti1*f, Elizabeth L. Johnson1,2 f, Connor J. Lemos2 and Silvia A. Bunge1,2. Helen Wills Neuroscience Institute, University of California at Berkeley, Berkeley, CA, USA 2 Department of Psychology, University of California at Berkeley, Berkeley, CA, USA. Edited by:. Jérôme Prado, Centre National de la Recherche Scientifique, France. Reviewed by:. Glenda Andrews, Griffith University, Australia. James Kenneth Kroger, New Mexico State University, USA. *Correspondence:. Michael S. Vendetti, Helen Wills Neuroscience Institute, University of California at Berkeley, 134 Barker Hall, Berkeley, CA 94720, USA e-mail: [email protected] f Shared first authorship.. Relational reasoning, or the ability to integrate multiple mental relations to arrive at a logical conclusion, is a critical ...
On removal of the skull cap there is found to be a thin film of subdural hemorrhage measuring approximately 7-8 cc over the surface of the right cerebral hemisphere and extending to the base of the cerebral hemisphere.The 1450 gm brain has a normal overall architecture. Mild narrowing of the sulci and flattening of the gyri are seen. No inflammation is identified.There is a thin film of subarachnoid hemorrhage overlying the entire right cerebral hemisphere. On the right cerebral hemisphere underlying the previously mentioned linear skull fracture is an extensive linear area of purple contusion extending from the right frontal area, posteriorly along the lateral aspect of the parietal region and into the occipital area. This area of contusion measures 8 inches in length with a width of up to 1.75 inches. At the tip of the right temporal lobe is a one-quarter by one-quarter inch similar appearing purple contusion. Only very minimal contusion is present at the tip of the left temporal lobe. This ...
On removal of the skull cap there is found to be a thin film of subdural hemorrhage measuring approximately 7-8 cc over the surface of the right cerebral hemisphere and extending to the base of the cerebral hemisphere.The 1450 gm brain has a normal overall architecture. Mild narrowing of the sulci and flattening of the gyri are seen. No inflammation is identified.There is a thin film of subarachnoid hemorrhage overlying the entire right cerebral hemisphere. On the right cerebral hemisphere underlying the previously mentioned linear skull fracture is an extensive linear area of purple contusion extending from the right frontal area, posteriorly along the lateral aspect of the parietal region and into the occipital area. This area of contusion measures 8 inches in length with a width of up to 1.75 inches. At the tip of the right temporal lobe is a one-quarter by one-quarter inch similar appearing purple contusion. Only very minimal contusion is present at the tip of the left temporal lobe. This ...
Unilateral spatial neglect (USN) is believed to be a disorder of attention, characterized by impairment in the ability to perceive or respond to stimuli presented to the contralesional space, and which is not attributable to significant sensory or motor deficits. USN has serious consequences for rehabilitation and long term disabilities. Efforts have been made to clarify both the theoretical basis of this phenomenon and the rehabilitation methods that will be best in improving function. The purpose of this study is to try and contribute to both efforts by examining treatment effectiveness of two methods; one targeting general arousal (phasic alerting), and the other targeting increasing awareness to left side stimuli and habit changes. Functional neuroimaging methods (PET [positron emission tomography] and fMRI [functional magnetic resonance imaging]) have been applied to understand the functional anatomy of the brain during mental processes. Only a few attempts have been made to use functional ...
In this study, the interaction of hand preference, eye dominance, and performance in archery was investigated. Beginners accuracy (right-handed French students (48 men, 34 women) from the University of Sport Sciences (M age = 19.3 yr., SD = 1.7 yr.), were tested and 1,323 practitioners were given a laterality questionnaire. Analysis suggested the interaction of hand preference and eye dominance might influence accuracy of the novice archers (uncrossed patterns were more accurate) when the bow was used without sights, but the use of sights by practitioners seemed to eliminate this effect.
Language processing is dynamic and requires the participation of both cerebral hemispheres. The left hemisphere (LH) is considered to be the language dominant hemisphere, however, the right hemisphere (RH) is also accepted to play an important role in language processing. The RH has been linked with processing of discourse, comprehension of inferences, ambiguity and metaphoric language, and underlying much of this, is its role in lexical-semantic processing [see for a review of RH language processing [1]]. According to dynamic models of cognitive functioning bilateral lexical-semantic processing will involve both interhemispheric activation and inhibition [2]. The language dominant LH is suggested to inhibit aspects of RH participation in order to maximize the efficiency of word level processing and meaning selection [2-4]. Interhemispheric inhibition has been suggested to limit the RHs ability to perform to its maximum semantic processing capacity under normal processing conditions, and to ...
Results-The FA laterality index for the cerebral peduncle-regions of interest was a poor predictor of 3-month outcome (R2=0.044; P=0.137), whereas the slope over the FA laterality index of the nearest-5-slices showed a relatively weak but significant prediction (R2=0.11; P=0.022) with the affected side having lower FA values. Initial upper extremity Fugl-Meyer (R2=0.69; P,0.001) and the weighted CST lesion load (R2=0.71; P,0.001) were strong predictors of 3-month outcome. In multivariate analyses, controlling for initial upper extremity Fugl-Meyer, weighted CST lesion load, and days-of-therapy, neither the FA laterality index of the cerebral peduncle nor the slope over the FA laterality index of the nearest-5-slices significantly contributed to the prediction of 86% of the variance in the upper extremity Fugl-Meyer at 3 months. ...
Near-infrared spectroscopy (NIRS) is certainly a novel technology for low-cost noninvasive brain imaging suitable for use in virtually all subject and patient populations. left IFG right IFG) than between IFG and MFG in the same hemisphere. Laterality indexes were calculated as t-values for the left > right comparisons of intrinsic connectivity within each regional group of channels in each subject. Regardless of handedness, the group average laterality indexes were negative thus revealing significantly higher connectivity in the right hemisphere in the majority of RH subjects and in both LH subjects. The analysis of Granger Causality between hemispheres has also shown a greater flow of info from the proper left hemisphere which might point to a significant role of the proper hemisphere in the relaxing condition. These data motivate additional exploration of the NIRS connection and its software for the evaluation of hemispheric interactions within the practical architecture of the mind. ...
Dirk Bruere at Neopax wrote: , Left and right visual data are procecessed by opposite hemispheres. , Is the same true of hearing, or is it left-left and right-right? , For hearing the process is basically the same. Sensory information (hearing, seeing, smelling...) is processed by specific neural cells, called sensory receptors. These neurons connect to the thalamus, and from that, to the respective sensory areas of the cortex. The only thing that you have to know is that in both, hearing and seeing, some sensory information coming from the left side goes to the same hemisphere (ipsilateral), and some goes to the opposite hemisphere (contralateral). For hearing the cells responsible for collecting the auditory information are the hair cells (or auditory receptor cells). They send the information through the auditory nerve to the brain stem, where they activate other neurons, which send the information to the both thalamus (medial geniculate nuclei). That means, it activates the same thalamic ...
begin{array}{l}\begin{array}{l}\frac{d}{dt}\left[S{I}_1\right]=\lambda \left(\left[SS{I}_1\right]+\left[SS{J}_1\right]-\left[{I}_1S{I}_1\right]-\left[{J}_1S{I}_1\right]-\left[{I}_2S{I}_1\right]-\left[{J}_2S{I}_1\right]\right)-\left(\lambda +\gamma \right)\left[S{I}_1\right]\\ {}+\sigma \left(\left[R{I}_1\right]+\left[{R}_1{I}_1\right]+\left[{R}_2{I}_1\right]\right)+\mu \left(\kappa \left[{I}_1\right]-2\left[S{I}_1\right]\right)\end{array}\hfill \\ {}\begin{array}{l}\frac{d}{dt}\left[S{I}_2\right]=\lambda \left(\left[SS{I}_2\right]+\left[SS{J}_2\right]-\left[{I}_1S{I}_2\right]-\left[{J}_1S{I}_2\right]-\left[{I}_2S{I}_2\right]-\left[{J}_2S{I}_2\right]\right)-\left(\lambda +\gamma \right)\left[S{I}_2\right]\\ {}+\sigma \left(\left[R{I}_2\right]+\left[{R}_1{I}_2\right]+\left[{R}_2{I}_2\right]\right)+\mu \left(\kappa \left[{I}_2\right]-2\left[S{I}_2\right]\right)\end{array}\hfill \\ {}\begin{array}{l}\frac{d}{dt}\left[S{R}_1\right]=-\lambda ...
Whole-brain functional magnetic resonance imaging was used to detect local hemodynamic changes reflecting cortical activation in five left handed and five right handed human subjects during bilateral stimulation of the tongue with various tastes. Activation was found bilaterally in the insula and th …
The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive force, it mediates the efflux of bile salts, detergents, organic solvents, and many structurally unrelated antibiotics. Here, we report a crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups that allow asymmetry of the monomers. This structure reveals three different monomer conformations representing consecutive states in a transport cycle. The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.. ...
We all know that the brain has two separate hemispheres but many people are not exactly sure what the function of each of these hemispheres are. The left hemisphere is responsible for logical thinking and communication skills. While the right hemisphere is responsible for symbolic thought and creativity, although recent research has been contradicting, proving that there are parts of the right hemisphere for creativity and vice versa. In left-handed people the functions are reversed. The left hemisphere is said to be dominant because of two specialized areas: Brocas area (B), motor cortex responsible for speech and Wernickes area (W), the cortex responsible for verbal comprehension.. The corpus callosum is located deep in the interhemispheric fissure, or sagittal fissure is the structure responsible for the connection between the two cerebral hemispheres. This structure, composed of nerve fibers white (Freixes axon wrapped in myelin), is responsible for the exchange of information between the ...
Blogpost by a member of our Interest Group by Tamás Molnár International migration law (hereinafter: IML) is a multi-layered body of law. It is composed of an ever-growing number of norms relating to various branches of international law such as human rights law, international refugee law, international labour law, international trade law, law of the…
Decreased diameter of the hepatic arteries following closing of a portacaval shunt Tandem-repeat protein domains, composed of repeated units of conserved stretches of 20-40 amino acids, are sildenafil 100mg required for a wide array of biological functions. Active demethylation in mouse zygotes involves cytosine deamination and base excision repair. Kruskal-Wallis test followed by post-hoc analysis was performed to test for differences between controls and OSA subgroups for testosterone, fatigue components and sleepiness. Cosmic voids refer sildenafil citrate 100mg to the large empty regions in the Universe with a very low number density of galaxies. To date, relapse risk can be female viagra pills predicted by leukocyte and platelet counts only. Rapamycin shows beneficial effects by reducing UUO-induced renal hypoxia, inflammation and tubulointerstitial fibrosis. Left-handedness: association with college major, familial sinistrality, allergies, and asthma.. Given that increased TNF-alpha ...
Kevin Leitchs Left Brain Right Brain autism blog closed today. Click the link and you will discover why: The reason LB/RB is shutting is because I cannot continue to allow my beautiful eldest girl to be exposed to the hatred...
Kevin Leitchs Left Brain Right Brain autism blog closed today. Click the link and you will discover why: The reason LB/RB is shutting is because I cannot continue to allow my beautiful eldest girl to be exposed to the hatred...
We provide a protocol for isolation of microglia from different dissected regions of an adult mouse brain hemisphere, followed by...
The left cerebral hemisphere controls movement of the right side of the body. Depending on the severity, a stroke affecting the left cerebral hemisphere may result in loss of motor skills and sensations on the right side of the body, and may also cause loss of the ability to speak and understand words ...
Midbrain activation is a new hot topic now. When we were children we read about superheroes that can see through wall. We saw in movies that a kung-fu master can fight with his eyes blinfolded. Midbrain (mesencephalon) is one part of brain that has a controlling function. Midbrain is act like a brain manager to manage the function of right and left brain. When we were a baby, our midbrain functioned well.. After 5 years old, midbrain of most of us becomes less active. Midbrain looses its capability to manage the left and right brain. The manager becomes lazy now. What happened with the left and right brain? Because this brain is the bigger brain, they still functioned well, but without the manager. These two big brains compete each other. Depend of the circumstances and character, one of the brains became a winner, and the other became looser.. If the left brain is the winner, left brain is used to solve most of the problem. We call this child left brain dominant. Children with left brain ...
An emerging topic in behavioural biology and psychology is brain lateralization. E.g. the asymmetrical organization of the brain in the left right plain. At first, this phenomenon was described only in humans, and was regarded as one of the extraordinary features of our „superior‟ brain. Later, it was discovered that lateralization exists in many animal species. This asymmetrical organization of the brain results in asymmetrical output called behaviour. The most common example of this in humans is handedness. Asymmetry is described in more and more behaviours, but its origin remains debated. Are they simply „nature‟; hard-coded in our DNA? Or are they „nurture‟ and caused by environmental conditions or experience? The subject of this thesis is asymmetries in visual perception in humans. It is easy to think we perceive the world in an unbiased way. But with an asymmetric brain, it is more likely that we also have asymmetrical perception. This study tries to answer some important ...
Two members of the Dodgers postseason starting rotation - Ryu and veteran left-hander Rich Hill - have signed elsewhere as free agents (the Blue Jays and Twins, respectively). The two take long medical records with them. But they combined for 81 starts over the past two seasons with a 36-14 record and 2.66 ERA. The Dodgers dipped into the deep waters of free agency but were rebuffed by Gerrit Cole and Stephen Strasburg. Instead, former Brewers right-hander Jimmy Nelson (coming back after two seasons of limited activity following shoulder surgery) and former Dodgers left-hander Alex Wood (limited to seven starts with the Reds due to a back injury last year) have been signed as low-cost bounceback candidates. They could add experienced depth to the rotation behind Buehler, Kershaw and Kenta Maeda. Along with Wood and Nelson, Julio Urias, May, Gonsolin and Ross Stripling will compete for starts and give the Dodgers their usual depth, allowing them to spread the regular-season workload ...
Define left brain: the left cerebral hemisphere of the human brain especially when viewed in terms of its predominant thought processes (such as…
definite evidence for language lateralisation arose from studies in split brain patients. In these patients, the nerve fibres that connect the two hemispheres were severed in order to stop the spread of epileptic seizures from one hemisphere to the other ... studies of these split brain patients were carried out in the 1960s and 1970s by the Nobel Prize laureate Roger Sperry and his colleagues at the Californian Institute of Technology ... Sperrys experiments yielded an amazing result: when split brain patients processed an object with their right hand, i.e. with their left hemisphere, they could easily name the object. In contrast, when an object was touched with the left hand, i.e. processed by the right hemisphere, they could not name it!. ...
article{MaDoSpGaHeBaHe12, author = {Bj\orn Machner and Michael Dorr and Andreas Sprenger and Janina von der Gablentz and Wolfgang Heide and Erhardt Barth and Christoph Helmchen}, title = {Impact of dynamic bottom-up features and top-down control on the visual exploration of moving real-world scenes in hemispatial neglect}, journal = {Neuropsychologia}, volume = {50}, year = {2012}, pages = {2415--2425}, pdf = {http://www.inb.uni-luebeck.de/publications/pdfs/MaDoSpGaHeBaHe12.pdf}, url = {http://dx.doi.org/10.1016/j.neuropsychologia.2012.06.012}, abstract = {. Patients with hemispatial neglect are severely impaired in orienting their attention to contralesional hemispace. Although motion is one of the strongest attentional cues in humans, it is still unknown how neglect patients visually explore their moving real-world environment.. We therefore recorded eye movements at bedside in 19 patients with hemispatial neglect following acute right hemisphere stroke, 14 right-brain damaged patients ...
Gur RE, Chin S (1999). "Laterality in functional brain imaging studies of schizophrenia". Schizophrenia Bulletin. 25 (1): 141- ... Similarly, there is now evidence to suggest there may be a number of functional and structural anomalies in the brains of some ... Some functional neuroimaging studies have also shown that, after taking amphetamine, patients diagnosed with schizophrenia show ... Arinami T, Gao M, Hamaguchi H, Toru M (April 1997). "A functional polymorphism in the promoter region of the dopamine D2 ...
Conditions include leftward functional hemispheric lateralization, loss of laterality for language comprehension, a reduction ... Split-brain Laterality Lateralization of brain function Alien hand syndrome Michael Gazzaniga Roger Wolcott Sperry Nielsen, J. ... Studies have found that individuals with schizophrenia have a lack in brain asymmetry thus reducing the functional efficiency ... right-brain hypothesis with resting state functional connectivity magnetic resonance imaging. PLOS ONE, 8(8), e71275. LeMay M ( ...
The teeth of plankton-feeders such as the basking shark are small and non-functional. Cartilaginous jaws and their teeth Jaw ... development and a genetic locus for jaw laterality in Lake Tanganyika scale-eating cichlids". BMC Biology. 8 (1): 8. doi: ... Mehta, R. S.; Wainwright, P. C. (2008). "Functional morphology of the pharyngeal jaw apparatus in moray eels" (PDF). Journal of ... Wainwright, P. C. (2006). "Functional Morphology of the Pharyngeal Jaw Apparatus". In Shadwick, R. E.; Lauder, G. V. (eds.). ...
Janovetz, Jeff (2005). "Functional morphology of feeding in the scale-eating specialist Catoprion mento" (PDF). The Journal of ... development and a genetic locus for jaw laterality in Lake Tanganyika scale-eating cichlids". BMC Biology. 8 (1): 8. doi: ... Stewart, T. A.; Albertson, R. C. (2010). "Evolution of a unique predatory feeding apparatus: functional anatomy, ...
... functional anatomy, development and a genetic locus for jaw laterality in Lake Tanganyika scale-eating cichlids". BMC Biology. ...
Stewart, T. A.; Albertson, R. C. (2010). "Evolution of a unique predatory feeding apparatus: functional anatomy, development ... and a genetic locus for jaw laterality in Lake Tanganyika scale-eating cichlids". BMC Biology. 8 (1): 8. doi:10.1186/1741-7007- ...
... and Roger Wolcott Sperry in the 1960s on split-brain patients led to an even greater understanding of functional laterality. ... Because of this functional division of the left and right sides of the body and of the space that surrounds it, the processing ... Furthermore, the functional map of the motor and sensory cortices is fairly consistent from person to person; Penfield and ... Lucas, Timothy (2004). "Functional separation of languages in the bilingual brain: a comparison of electrical stimulation ...
Mazzarello, Paolo (2011). "Cesare Lombroso: an anthropologist between evolution and degeneration". Functional Neurology. 26 (2 ... Laterality: Asymmetries of Body, Brain and Cognition. 18 (4): 416-436. doi:10.1080/1357650x.2012.697171. PMID 22757625. S2CID ... Laterality. 18 (4): 416-436. doi:10.1080/1357650X.2012.697171. PMID 22757625. S2CID 30990112. Bailey, Frankie Y. (Winter 2005 ...
2002). "Sex differences in functional brain activation during a lexical visual field task". Brain and Language. 80 (1): 97-105 ... 2006). "Sex differences in cerebral laterality of language and visuospatial processing". Brain and Language. 98 (2): 150-158. ... 1995). "Sex differences in the functional organization of the brain for language". Nature. 373 (6515): 607-609. doi:10.1038/ ... 2003). "Sex differences in semantic language processing: A functional MRI study". Brain and Language. 84 (2): 264-272. doi: ...
The unusual functional laterality in speech production (e.g. right hemisphere auditory processing) found in some individuals ...
... reflecting a significant sex difference in the magnitude of laterality effects, with men obtaining larger laterality effects ... Kimura, Doreen (1967). "Functional Asymmetry of the Brain in Dichotic Listening". Cortex. 3 (2): 163-178. doi:10.1016/S0010- ... In order to obtain results, a Functional magnetic resonance imaging (fMRI) was used by Jancke et al (2001) to determine the ... In 1994, M.F. Green and colleagues tried to relate "the functional integration of the left hemisphere in hallucinating and ...
While developed for functional status evaluation, the HCS prototype ultimately led to the discovery of the brain vital signs ... March 15, 2012). "Spatial MEG Laterality maps for language: Clinical applications in epilepsy." Human Brain Mapping. Vol. 34:8 ... Gawryluk JR, Mazerolle EL and D'Arcy RCN (August 8, 2014) "Does functional MRI detect activation in white matter? A review of ... Gawryluk, Jodie R.; Mazerolle, Erin L.; Beyea, Steven D.; D'Arcy, Ryan C. N. (2014-08-04). "Functional MRI activation in white ...
Functional and structural differences between left and right brain hemispheres can be found in many other vertebrates and also ... This has been called the "laterality-valence hypothesis". One sub-set of laterality in animals is limb dominance. Preferential ... testing for laterality can be a useful predictor of a successful guide dog. Knowing a guide dog's laterality can also be useful ... causing strains to differ in the degree of laterality of its individuals. Long-term memory of previously gained laterality in ...
After capturing a set of baseline images, some labs further require the patient to undergo cold-water autonomic-functional- ... laterality reconstruction, (b) motor imagery, and (c) mirror therapy. Transcutaneous Electrical Nerve Stimulation (TENS) ... Evidence supports its use in treating pain and edema associated with CRPS although it doesn't seem to increase functional ... a functional MRI study". Pain. 114 (1-2): 93-103. doi:10.1016/j.pain.2004.12.001. PMID 15733635. S2CID 19187294. DR WILL HOWARD ...
Functional neuroimaging methods such as PET and fMRI are used to study the complex neural mechanisms of the human language ... Most neuroimaging studies show no laterality differences between monolingual and bilingual speakers, supporting the hypothesis ... Using functional magnetic resonance imaging (fMRI), representations of L1 and L2 have been found in spatially isolated parts of ... Functional imaging methods have revealed that holding proficiency constant leads to age of acquisition not having a large ...
doi:10.2190/em.27.1.f. Xenakis, Ioannis; Arnellos, Argyris; Darzentas, John (1 August 2012). "The functional role of emotions ... Powell, W. Ryan; Schirillo, James A. (1 August 2011). "Hemispheric laterality measured in Rembrandt's portraits using pupil ...
Chicago: Nelson-Hall (1983) Human Laterality, Academic Press (1984) The Lopsided Ape: Evolution of the Generative Mind, Oxford ... doi:10.1016/j.neuropsychologia.2008.10.016 Milivojevic, B., Hamm, J. P., & Corballis, M. C. (2009). "Functional neuroanatomy of ...
Laterality, 11, 373-393. Jeffery, G. (2001). Architecture of the optic chiasm and the mechanisms that sculpt its development. ... A critical assumption has been that differences in performance with lateralized stimuli nearly always reflect functional ... Banich, M.T. (2003). The divided visual field technique in laterality and interhemispheric integration. In K. Hughdahl (Ed.), ... if a cerebral hemisphere has functional advantages with some aspect of a particular task, an experimenter might observe ...
The valence-specific laterality effect in free viewing conditions: The influence of sex, handedness, and response bias. Brain ... Functional asymmetry of emotions in primates: new findings in chimpanzees. Brain Research Bulletin. 57: 561-564, 2002. Vytal, K ... Below are a few regions and structure involved in emotional processing that show functional lateralization. Using a PET scan, ... The vast majority of the data comes from functional imaging, skin conductance response (SCR), standardized tests ranging from ...
Anatomo-functional study of the temporo-parieto-occipital region: dissection, tractographic and brain mapping evidence from a ... A Quantitative Tractography Study Into the Connectivity, Segmentation and Laterality of the Human Inferior Longitudinal ... Proc Natl Acad Sci U S A. Feb 4;111(5):1981-6. doi: 10.1073/pnas.1324037111 Herbet G, Zemmoura I, Duffau H. Functional Anatomy ... Based on these recent findings ILF can be described as a multi-functional white matter pathway involved in visually guided ...
Sergent, J (1992). "Functional neuroanatomy of face and object processing : A positron emission tomography study". Brain. 115 ( ... Sergent, J. (1987). Information processing and laterality effects for object and face perception. In G. W. Humphreys, & M. J. ... Justine Sergent was one of the first researchers that brought forth evidence towards the functional neuroanatomy of face ... Sergent, J., MacDonald, B., Zuck, E. (1994). Structural and functional organization of knowledge about faces and proper names ...
Functional approaches rely on understanding what roles emotions play in humans and examining that role in animals. A widely ... Barnard, S., Matthews, L., Messori, S., Podaliri-Vulpiani, M. and Ferri, N. (2015). "Laterality as an indicator of emotional ... Mendl, M., Burman, O.H.P. and Paul, E.S. (2010). "An integrative and functional framework for the study of animal emotion and ... Dawkins suggests that merely mechanistic or functional research will provide the answer on its own, but suggests that a mixture ...
Incidence and laterality". J AAPOS. 11 (4): 367-372. doi:10.1016/j.jaapos.2007.02.017. PMID 17588790. Huang MH, Gruss JS, ... but also the functional aspect. This is especially prevalent with asymmetric conditions, such as unilateral coronal synostosis ... "Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile". ...
a b c d e f g Ruppert, E. E., Fox, R. S. and Barnes, R. D. Invertebrate Zoology: A Functional Evolutionary Approach. Thomson, ... Laterality. *Proper right and proper left - terms for unambiguous directions, like port and starboard ... Some species (mainly troglobites) have no functional eyes at all. In what is seen as the likeliest ancestral arrangement of the ...
In: Human Laterality, Davidson RH, Hugdahl K, eds. Cambridge, MA: MIT Press, pp. 491-532 Nebes RD, ed. (1990): The ... There is little functional plasticity observed in partial and complete callosotomies; however, much more plasticity can be seen ... There is little functional plasticity observed in partial and complete callosotomies on adults, the most neuroplasticity is ... Funnell M. G.; Corballis P. M.; Gazzaniga M. S. (2000). "Insights into the functional specificity of the human corpus callosum ...
Some species (mainly troglobites) have no functional eyes at all. In what is seen as the likeliest ancestral arrangement of the ... Laterality - Preference most humans show for one side of their body over the other ... Ruppert, EE; Fox, RS; Barnes, RD (2004). Invertebrate zoology : a functional evolutionary approach (7th ed.). Thomson, Belmont ...
Kim J, Ahn S, Ren XR, Whalen EJ, Reiter E, Wei H, Lefkowitz RJ (2005). "Functional antagonism of different G protein-coupled ... a series of developmental defects arising from improper left-right laterality during organogenesis. Overexpression of GRK5 in ... also called functional selectivity), where a drug binding to a receptor may bias that receptor's signaling toward a particular ...
Other critical functional parts are the N-terminal Cobl Homology domain, which can also be found in the ancestor of Cobl, Cobl- ... Zebra fish deficient for Cobl showed severe defects in body laterality and balance keeping. Several actin nucleators are ... An important functional part of this actin-nucleating protein is the C-terminus, which contains 3 Wiskott-Aldrich syndrome ... Cobl was then cloned fully and its neuronal functions were characterized in primary neuronal cultures in functional slices of ...
Incidence and laterality". J AAPOS. 11 (4): 367-372. doi:10.1016/j.jaapos.2007.02.017. PMID 17588790.. ... but also the functional aspect.[42] This is especially prevalent with asymmetric conditions, such as unilateral coronal ... "Long-term functional outcome in 167 patients with syndromic craniosynostosis; defining a syndrome-specific risk profile". ...
Boso M, Politi P, Barale F, Enzo E (2006). "Neurophysiology and neurobiology of the musical experience". Functional Neurology. ... laterality and directional.[34][self-published source?] Music can both motivate and provide a sense of distraction.[33] ... prolonged and marked functional impairment; and 6) hallucinatory experiences other than thinking that he or she hears the voice ...
Ruppert, EE; Fox, RS; Barnes, RD (2004). Invertebrate zoology : a functional evolutionary approach (7th ed.). Thomson, Belmont ... Laterality - Preference most humans show for one side of their body over the other ...
Obeso JA, Rodríguez-Oroz MC, Benitez-Temino B, Blesa FJ, Guridi J, Marin C, Rodriguez M (2008). "Functional organization of the ... "A preliminary investigation of laterality in Parkinson's disease and susceptibility to psychosis". Journal of Neurology, ... physiotherapists have a variety of strategies to improve functional mobility and safety. Areas of interest with respect to gait ...
Rarely, left atrial isomeric patients have a single, normal, functional spleen. Patients lacking a functional spleen are in ... Heterotaxy in general refers to any defect of left-right laterality and arrangement of the visceral organs. This does not ... Functionally asplenic patients have an elevated lifetime risk of septicemia, as they have no functional spleen for fighting ... Left-atrial isomeric patients have less severe complications, as they typically have 2 functional ventricles. In this case, ...
This immunisation is not functional against a different tumour. It was used in autologous manner in clinical studies for gp96 ... Along with hspb7, hspb12 is involved in cardiac laterality determination.[9] A kinase of the nitric oxide cell signalling ... "Functional significance of hsp90 complexes with NOS and sGC in endothelial cells". Clinical Hemorheology and Microcirculation ... "Small heat shock proteins are necessary for heart migration and laterality determination in zebrafish". Developmental Biology ...
... and functional dyspepsia.[50] Alexithymia is further linked with disorders such as migraine headaches, lower back pain, ... "Laterality of expression in portraiture: putting your best cheek forward". Proceedings of the Royal Society of London B: ... "Alexithymia and somatosensory amplification in functional dyspepsia". Psychosomatics. 45 (6): 508-16. doi:10.1176/appi.psy. ...
"Laterality. 12 (1): 31-49. doi:10.1080/13576500600886796. PMID 17090448.. *^ Gauthier I, Skudlarski P, Gore JC, Anderson AW; ... using a novel functional transcranial Doppler (fTCD) technique called functional transcranial Doppler spectroscopy (fTCDS), ... Smith WM (July 2000). "Hemispheric and facial asymmetry: gender differences". Laterality. 5 (3): 251-8. doi:10.1080/713754376. ... Data from magnetic resonance imaging and functional magnetic resonance imaging has shown that a smaller volume of the fusiform ...
Functional transcranial Doppler (fTCD)[edit]. Functional transcranial Doppler sonography (fTCD) is a neuroimaging tool for ... Laterality. 12 (1): 31-49. doi:10.1080/13576500600886796. PMID 17090448.. *^ Meinders, JM; Kornet, L; Brands, PJ; Hoeks, AP ( ... Functional transcranial Doppler spectroscopy (fTCDS)[edit]. This section may require cleanup to meet Wikipedia's quality ... The method was first described by Philip Njemanze in 2007, and was referred to as functional transcranial Doppler spectroscopy ...
a b c d e f g Ruppert, E. E., Fox, R. S. and Barnes, R. D. Invertebrate Zoology: A Functional Evolutionary Approach. Thomson, ... Some species (mainly troglobites) have no functional eyes at all. In what is seen as the likeliest ancestral arrangement of the ... Laterality. * Proper right and proper left. * Reflection symmetry. * Sinistral and dextral. * Direction (disambiguation) ...
FunctionalEdit. Functional approaches rely on understanding what roles emotions play in humans and examining that role in ... This has been called the "laterality-valence hypothesis".[12]. Basic and complex human emotionsEdit. In humans, a distinction ... LateralityEdit. It has been proposed that negative, withdrawal-associated emotions are processed predominantly by the right ... A widely used framework for viewing emotions in a functional context is that described by Oatley and Jenkins[22] who see ...
Both the right and left hemispheres generate an N1, but the laterality of the N1 depends on whether a stimulus is presented ... Functional dissociation of P1 and N1 components. Electroencephalography & Clinical Neurophysiology, 75(6): 528-542. Callaway, E ...
Cuvier's insistence on the functional integration of organisms led him to classify animals into four "branches," or ... Glossary of plant morphology Glossary of leaf morphology Glossary of entomology terms Plant morphology Handedness Laterality ... Cuvier's insistence on the functional integration of organisms led him to classify animals into four "branches," or ...
Komisaruk, B., & Whipple, B.; Whipple (2005). "Functional MRI of the brain during orgasm in women". Annual Review of Sex ... Cohen, Harvey D.; Rosen, Raymond C.; Goldstein, Leonide (May 1976). "Electroencephalographic laterality changes during human ... Before Komisaruk et al.'s functional magnetic resonance (fMRI) research on nipple stimulation in 2011, reports of women ... when several women stimulated themselves in a functional magnetic resonance (fMRI) machine. "I think that the bulk of the ...
The laterality of the sensory inputs makes a difference insofar as left-sided inputs directed to the intact left hemisphere are ... Different degrees of multisensory integration may occur depending upon the functional relevance of a given modality. Altogether ... Jan 1982). "Failure to obtain functional equivalence between dopamine receptor blockade and extinction: evidence supporting a ...
... and cerebral laterality". Journal of Experimental Psychology: Learning, Memory, and Cognition. 9 (3): 544-555. doi:10.1037/0278 ... impair cognitive functions but leave emotional responses fully functional. The mere-exposure effect posits that repeated ...
ISBN 978-81-7141-746-9. William O. Reece (2009). Functional Anatomy and Physiology of Domestic Animals. John Wiley & Sons. ISBN ... Laterality. 15 (5): 514-534. doi:10.1080/13576500903049324. PMID 19629847. S2CID 13283847. Proctor, Helen S.; Carder, Gemma (9 ...
Craniofacial laterality in the scale-eating specialist Perissodus microlepis was found to be evident early in development and ... Continued work on the developmental genetic basis of laterality in the Perissodini will facilitate a better understanding of ... Here we examine the evolution and development of craniofacial morphology and laterality among Lake Tanganyika scale-eating ... we show that the evolutionary history of the Perissodini is characterized by an accentuation of craniofacial laterality such ...
Functional laterality refers to a natural asymmetry in left or right-side dominance, for example in terms of handedness... ... What is functional laterality? Functional laterality refers to a natural asymmetry in left or right-side dominance, for example ... What is the evidence for altered functional laterality?. High quality evidence shows that people with schizophrenia are more ... as well as altered visual and auditory dominance that may reflect abnormalities in brain laterality and dominance. ...
What is functional laterality? Functional laterality refers to a natural asymmetry in left or right-side dominance, for example ... What is the evidence for altered functional laterality?. High quality evidence shows that people with schizophrenia are more ... as well as altered visual and auditory dominance that may reflect abnormalities in brain laterality and dominance. ...
... positive results that are progressively retained over time specific to patient-centered outcome measures as well as functional ... Laterality of Motor Control and Induced Gamma-Band Activity During Voluntary Movement: A Clinical Perspective of an Inexpensive ... 428" contains a laterality-indexed item not sufficiently emphasized by the authors. Using electroencephalography and ...
Comparative and Functional Genomics. Volume 2 (2001), Issue 2, Pages 60-68. http://dx.doi.org/10.1002/cfg.74. Research Article ... Genetic Steps to Organ Laterality in Zebrafish. Jau-Nian Chen,1,2 Frauke van Bebber,3 Allan M. Goldstein,1,2 Fabrizio C. ... That laterality decisions of organs may be independently perturbed, as in the Class 3 mutation, indicates that there are ... We find that the mutations can be classified on the basis of whether they perturb relationships among organ laterality. In ...
... Neurosci Res. 2009 Jun;64(2):240-2. doi: 10.1016/j.neures ... Functional Laterality* * Male * Mice * Neocortex / physiology* * Neurons / physiology * Occipital Lobe / physiology * Parietal ...
Brain laterality in schizophrenia has been examined through the application of functional neuroimaging methods. These methods ... Brain laterality in schizophrenia has been examined through the application of functional neuroimaging methods. These methods ... Recent advances in basic and clinical neuroscience provide an opportunity for focused application of functional imaging in ... and functional magnetic resonance imaging for measuring changes attributable to CBF. This article highlights the application of ...
Effect of voicing on perceptual auditory laterality in Estonian and Norwegian native speakers - Volume 39 Issue 2 - RENÉ ... Van der Haegen, L., Westerhausen, R., Hugdahl, K., & Brysbaert, M. (2013). Speech dominance is a better predictor of functional ... Laterality, 20, 434-452. Brancucci, A., Penna, S. D., Babiloni, C., Vecchio, F., Capotosto, P., Rossi, D., Rossini, . . ., P., ... Laterality, 15, 343-360. Asu, E. L., & Teras, P. (2009). Estonian. Journal of the International Phonetic Association, 39, 367- ...
... laterality defects including heart malformations, infertility and hydrocephalus. Using linkage analysis and whole exome ... Homozygous Loss-Of-Function Mutations in MNS1 Cause Laterality Defects and Likely Male Infertility PLoS Genet. 2018 Aug 27;14(8 ... Consistent with the laterality defects observed in these individuals, we found Mns1 to be expressed in mouse embryonic ventral ... Overall, we demonstrate that MNS1 deficiency in humans causes laterality defects (situs inversus) and likely male infertility ...
At a functional level, the medial prefrontal cortex is involved in multiple processes relevant to emotion regulation, including ... Functional Neuroimaging. Negative Emotion Induction Manipulation Check. To assess if the combat images elicited a neural ... New, A. S., Fan, J., Murrough, J. W., Liu, X., Liebman, R. E., Guise, K. G., … Charney, D. S. (2009). A functional magnetic ... Functional MRI Statistical Analysis. The fMRI data were analyzed using SPM8 software (Wellcome Department of Cognitive ...
Auditory scene analysis; Event-related brain potentials (ERPs); Hemispheric laterality; Neural compensation; Reverse hierarchy ... Functional changes in inter- and intra-hemispheric cortical processing underlying degraded speech perception.. Bidelman GM1, ... and show a shift in the functional lateralization of cerebral processing from left to right hemisphere. Increased right ... Our findings demonstrate changes in the functional asymmetry of cortical speech processing during adverse acoustic conditions ...
The laterality patterns of functional asymmetries were found to be consistent and independent of the conventional upper and ... Even though laterality was confirmed in both grip and elbow flexion, gender difference is more marked in hand grip. ... This study aimed to compare the laterality, and its gender difference, of hand grip and elbow flexion power according to load ... Laterality of Hand Grip and Elbow Flexion Power in Right Hand-Dominant Individuals ...
Effects of Lesion Location and Laterality. No significant differences were found in the patterns of activation between patients ... Subjects had to score 3 or above on the Functional Ambulatory Capacity rating scale.19 Their mean (SD) Functional Ambulatory ... Functional MRI Correlates of Lower Limb Function in Stroke Victims With Gait Impairment. Christian Enzinger, Heidi Johansen- ... Functional anatomy of human procedural learning determined with regional cerebral blood flow and PET. J Neurosci. 1992; 12: ...
Functional laterality‎ (20 Ф). H. *. ► Hippocampus (anatomy)‎ (11 К, 1 С, 74 Ф) ...
... which explores the functional relationships between hormones and the brain, have indicated that the release of testicular ( ... Voyer, D. (1996). On the magnitude of laterality effects and sex differences in functional literalities. Laterality 1, 51-83. ... In research conducted in the 1990s, sex differences in humans have also been found for functional asymmetry (Voyer, 1996), ... Findings in the field of neuroendocrinology, which explores the functional relationships between hormones and the brain, have ...
Bryden, M. (1982). Laterality: Functional asymmetry in the intact brain. New York: Academic Press.Google Scholar ... Goff, E., Allison, T. & Vaughan, H. (1978). The functional neuroanatomy of event related potentials. In E. Callaway, E. Teuting ...
... the Example of Auditory Laterality - Polish Psychological Bulletin ... Brain Functional Asymmetry of Chimpanzees (Pan troglodytes): the Example of Auditory Laterality Journal title. Polish ... Brain Functional Asymmetry of Chimpanzees (Pan troglodytes): the Example of Auditory Laterality. Justyna Szymańska; Maciej ... Cantalupo (2001), Asymmetric Broca s area in great apes, Nature, 414. ; Rogers (1989), Laterality in animals, The International ...
In this work, we report two patients with a DAND5 heterozygous non-synonymous variant (c.455G , A) in the functional domain of ... A Nodal-dependent luciferase assay was conducted in order to determine the functional effect of the variant found. ... Altogether, our results provide new insight into the molecular mechanism of the laterality defects and related CHDs, priming ... The functional analysis assay showed a significant decrease in the activity of this variant protein when compared to its wild- ...
Laterality and neuropsychiatric disorders: Schizophrenia and the left hemisphere.. *Laterality and differential functional ... Course 3: Laterality and Functional Organization of the Brain. Topics covered:. *Where the traditional notions of hemispheric ... Laterality and learning disabilities (dyslexias vs NVLD).. *Laterality and dementias: Is fronto-temporal dementia lateralized? ... Laterality and Brain Dysfunction Ended $95.00 $0.00 Combined ticket for any two courses (please click on Order Now and scroll ...
Functional cerebral asymmetry in auditory motion perception. Laterality, 12, 87-99.. Book sections:. *Hugdahl, K. & Hirnstein, ... Ocklenburg, S., Güntürkün, O., Hugdahl, K. & Hirnstein, M. (2015). Laterality and mental disorders in the postgenomic age - A ... Ocklenburg, Sebastian; Güntürkün, Onur; Hugdahl, Kenneth; Hirnstein, Marco. 2015. Laterality and mental disorders in the ... The evolutionary origins of functional cerebral asymmetries in humans: Does lateralization enhance parallel processing? ...
Both headache laterality and headache type interact with the degree of co-morbidity with higher impairment in patients with ... Both headache laterality and headache type interact with the degree of co-morbidity with higher impairment in patients with ... Here we aimed to investigate the influence of co-morbid headache type and headache laterality on tinnitus characteristics. ... Based on these data patients were categorized according to headache type and headache laterality and their clinical ...
Laterality: Functional Asymmetry In The Intact Brain. New York: Appleton Century.Carr, M. 1983. Sidelights on Xin Heart, Mind ... And thiscan be studied in laterality differences today. What I have tried to present to you is a long and complicated story. It ... The space of consciousness, which I shallhereafter call mind-space, is a functional space that has no location except as we ... and has only an arbitrary and functional location. As a prel-ude to what I am to say later, I wish you to consider that there ...
Here, we propose a new hypothesis that binary opposition in functional incompatibility applies selection pressure on the ... Here, we propose a new hypothesis that binary opposition in functional incompatibility applies selection pressure on the ... 2003). Local tissue interactions across the dorsal midline of the forebrain establish CNS laterality. Neuron 39, 423-438. doi: ... Brain asymmetry and functional lateralization are recognized in many vertebrates. It is well-known that the left side of the ...
Functional Laterality. Humans. Migraine Disorders / complications*, physiopathology, radiography. Occipital Lobe / blood supply ...
Functional Laterality. Head Movements / physiology*. Models, Biological. Physical Stimulation / methods. Probability. Rats. ... Next Document: Probability-based prediction of activity in multiple arm muscles: implications for functional electr.... ...
functional connectivity. HC. hippocampus. LI. laterality index. MTS. mesiotemporal sclerosis. nl-TLE. nonlesional TLE. TLE. ... RESULTS: Laterality indices based on fMRI activation maps failed to discriminate among patient groups. Functional connectivity ... Task-based activation maps (laterality indices) and functional connectivity analysis (global and connectivity strengths between ... We hypothesized that different epileptogenic lesions are related to distinct alterations in the functional language connectome ...
V. Emotional Laterality. PDF (95.2 KB). *14. The Functional Neuroimaging of Human Emotion: Asymmetric Contributions of Cortical ... visual laterality, auditory laterality, emotional laterality, neurological disorders, and psychiatric disorders. ... Functional Magnetic Resonance Imaging. Hemispheric Specialization. Hippocampus. Limbic System. Magnetic Resonance Imaging. ... Going beyond the authors previous book, Brain Asymmetry, this book reflects the most recent thinking on functional asymmetries ...
... and laterality differences (Schneider et al., 2000; Cahill et al., 2001; Canli et al., 2002) compared with men, likely ... coplanar to the functional images for anatomic localization. Finally, a series of functional scans were acquired, using an ... Three sets of functional scans were acquired. Functional images were visually examined in Statistical Parametric Mapping (SPM) ... These blocks were repeated four times during each 6 min functional scan. Three functional scans were taken, resulting in 12 ...
Seghier M (2008) Laterality index in functional MRI: methodological issues. Magn Reson Imaging 26:594-601. doi: 10.1016/j.mri. ... Laterality 18:1-31. doi: 10.1080/1357650X.2011.626561 CrossRefPubMedGoogle Scholar ... 2, 3, 4, 6, 7) may underpin this proposed functional lateralization of frequency processing and the lateralized production of ... Future DTI and functional MRI (fMRI) studies of T. truncatus and other cetaceans are needed to characterize cerebral white ...
Laterality of motor control and consciousness shares the same hemisphere. [Anesthesiology. 2013] ... Regional association of thalamocortical functional connectivity with changes of the state of consciousness. Indices IA and IB ... Functional connectivity was determined as the temporal correlation of blood oxygen level-dependent signals with seed regions ... Regional distributions of specific (A) and nonspecific (B) thalamocortical functional connectivity as measured by voxel count ...
  • Functional laterality refers to a natural asymmetry in left or right-side dominance, for example in terms of handedness, or brain function. (edu.au)
  • Our findings demonstrate changes in the functional asymmetry of cortical speech processing during adverse acoustic conditions and suggest that "cocktail party" listening skills depend on the quality of speech representations in the left cerebral hemisphere rather than compensatory recruitment of right hemisphere mechanisms. (nih.gov)
  • Laterality: Functional asymmetry in the intact brain. (springer.com)
  • Here, we propose a new hypothesis that binary opposition in functional incompatibility applies selection pressure on the habenular circuit and leads to asymmetry. (frontiersin.org)
  • Brain asymmetry and functional lateralization are recognized in many vertebrates. (frontiersin.org)
  • This study represents the first examination of cetacean white matter asymmetry and constitutes an important step toward understanding potential drivers of structural asymmetry and its role in underpinning functional and behavioral lateralization in cetaceans. (springer.com)
  • Going beyond the authors' previous book, Brain Asymmetry , this book reflects the most recent thinking on functional asymmetries and their structural correlates in brain anatomy. (mit.edu)
  • Hypnotizability, laterality of eye movements and functional brain asymmetry. (thenakedscientists.com)
  • Several vertebrates, including fish, exhibit behavioural laterality and associated morphological asymmetry. (biologists.org)
  • We also compared the behavioural laterality and mouth asymmetry of G. mento and P. microlepis . (biologists.org)
  • Using this technique he investigated amongst others functional reorganization after stroke in motor and visual cortex, resting state activity in visual cortex, and topological asymmetry between the hemispheres. (umcutrecht.nl)
  • Functional left/right asymmetry ("laterality") is a fundamental feature of many nervous systems, but only very few molecular correlates to functional laterality are known. (genetics.org)
  • and auditory laterality and speech perception, memory, and asymmetry in the context of developmental, neurological, and psychiatric disorders. (mit.edu)
  • Failure to establish normal left-right (L-R) asymmetry often results in cardiovascular malformations and other laterality defects of visceral organs. (ahajournals.org)
  • Laterality defects refer to a broad group of disorders caused by the disruption of normal left-right (L-R) asymmetry of the thoracic or abdominal visceral organs. (ahajournals.org)
  • The current study used functional magnetic resonance imaging (fMRI) to assess neural activity during task preparation and image presentation during different emotion regulation strategies, cognitive reappraisal and expressive suppression, in PTSD. (springer.com)
  • The potential of functional MRI (fMRI) to identify changes in cortical activation patterns associated with different levels of recovery has been demonstrated in several studies probing functional consequences of brain damage. (ahajournals.org)
  • We therefore used fMRI and an active and passive ankle dorsiflexion paradigm to test for cortical functional reorganization in patients with gait impairment and chronic disability after stroke. (ahajournals.org)
  • Our aims were to use ankle dorsiflexion as an analog of hand flexion-extension to test for evidence of potentially compensatory activation in patients with lower limb paresis after stroke as has been found for the upper limb and to determine whether interindividual differences in the poststroke fMRI response are correlated with the degree of functional impairment of the lower limb. (ahajournals.org)
  • We hypothesized that different epileptogenic lesions are related to distinct alterations in the functional language connectome detected by fMRI. (ajnr.org)
  • Laterality indices based on fMRI activation maps failed to discriminate among patient groups. (ajnr.org)
  • This functional magnetic resonance imaging (fMRI) study demonstrated significant differences in activation of hypothalamic-pituitary-adrenal (HPA) circuitry in adult women with attenuation during ovulation and increased activation during early follicular phase. (jneurosci.org)
  • We performed functional magnetic resonance imaging (fMRI) to investigate the neural correlates of tactile SJ using tactile number judgement as a time-irrelevant control task. (nature.com)
  • In our previous functional magnetic imaging (fMRI) study 9 , we directly compared the neural correlates of tactile TOJ with those of SJ. (nature.com)
  • The extremely variable neurocognitive profiles in surgical epilepsy patients cannot be fully explained by extent of resection, fiber integrity, or current task-based functional MRI (fMRI). (thejns.org)
  • Functional connectivity, activation maps, and laterality indices for language dominance were analyzed from fMRI data. (thejns.org)
  • Methods 57 patients with epilepsy were identified with language functional MRI (fMRI) and diffusion MRI acquisition. (bmj.com)
  • In individual subjects, some studies have shown a correlation between the volume of the arcuate fasciculus tract and language lateralisation, determined by the WADA test 4 and by functional MRI (fMRI)I, 5 while others have not found a consistent association. (bmj.com)
  • ABSTRACT: Neural activity during language production in aphasia typically has been measured using functional magnetic resonance imaging (fMRI) during silent production tasks. (ufl.edu)
  • Functional magnetic resonance imaging (fMRI) can be used to non-invasively map language function in the human brain. (edu.au)
  • An fMRI study of the relative laterality of dominant and non-dominant hand sensory function. (edu.au)
  • WASHINGTON - (December 11, 2017) - Functional magnetic resonance imaging (fMRI) has allowed researchers to map the memory functions that are often impaired within the brains of children with epilepsy. (eurekalert.org)
  • A second study demonstrated the ability of functional connectivity analysis within a resting-state fMRI to assess language laterality, meaning to help determine the dominant side of the brain controlling language, when compared with the current standard of a language-task fMRI measure. (eurekalert.org)
  • The study found that when compared with typical language assessment tasks, resting state fMRI functional connectivity analysis matched the results of the task activity findings slightly more than two thirds of the time. (eurekalert.org)
  • While more research is needed, the study succeeded in demonstrating the potential of data-driven methods to establish reliable language laterality even without a task-based fMRI. (eurekalert.org)
  • To investigate this issue, we scanned younger and older adults with functional magnetic resonance imaging (fMRI) while performing three different tasks: working memory, visual attention and episodic retrieval. (diva-portal.org)
  • 4. - 5 The neuroimaging techniques such as functional magnetic resonance imaging (fMRI) and positron emission tomography (PET) have been widely used to image brain functions for many neurodegenerative diseases. (spiedigitallibrary.org)
  • Previous studies to determine memory lateralization with functional MR imaging (fMRI) have used encoding or recall tasks. (ajnr.org)
  • 2 - 5 In recent years, there has been an increasing interest in the utility of functional MR imaging (fMRI) for presurgical evaluation of memory. (ajnr.org)
  • This is undertaken using a variety of methods including studying patients in whom the hemispheres have been surgically separated (a callosotomy or split brain), functional magnetic resonance (fMRI) and diffusion tensor imaging (DTI), and event-related potentials (ERP). (plymouth.ac.uk)
  • In right TLE, left frontal language dominance correlated with good semantic verbal fluency before and after surgery, and left fronto-temporal language laterality predicted good naming outcome. (thejns.org)
  • Measurement of language laterality using functional transcranial Doppler ultrasound: a comparison of different tasks. (ox.ac.uk)
  • The data-driven method of identifying language laterality through functional connectivity analysis was developed previously at Children's National and applied in this setting to test its ability to map the dominant regions of the brain controlling language. (eurekalert.org)
  • The clinical spectrum of ciliopathies affecting motile cilia spans impaired mucociliary clearance in the respiratory system, laterality defects including heart malformations, infertility and hydrocephalus. (nih.gov)
  • Using linkage analysis and whole exome sequencing, we identified two recessive loss-of-function MNS1 mutations in five individuals from four consanguineous families: 1) a homozygous nonsense mutation p.Arg242* in four males with laterality defects and infertility and 2) a homozygous nonsense mutation p.Gln203* in one female with laterality defects and recurrent respiratory infections additionally carrying homozygous mutations in DNAH5. (nih.gov)
  • Consistent with the laterality defects observed in these individuals, we found Mns1 to be expressed in mouse embryonic ventral node. (nih.gov)
  • Overall, we demonstrate that MNS1 deficiency in humans causes laterality defects (situs inversus) and likely male infertility and that MNS1 plays a role in the ODA-DC assembly. (nih.gov)
  • Perturbations on the Left-Right axis establishment lead to laterality defects, with frequently associated Congenital Heart Diseases (CHDs). (biomedcentral.com)
  • Indeed, in the last decade, it has been reported that the etiology of isolated cases of CHDs or cases of laterality defects with associated CHDs is linked with variants of genes involved in the Nodal signaling pathway. (biomedcentral.com)
  • Altogether, our results provide new insight into the molecular mechanism of the laterality defects and related CHDs, priming for the first time DAND5 as one of multiple candidate determinants for CHDs in humans. (biomedcentral.com)
  • Laterality defects are developmental disorders resulting from aberrant left/right patterning. (biologists.org)
  • It is compatible with automated and quantitative image analyses, which is essential to compare mutant phenotypes with incomplete penetrance and to gain mechanistic insight into laterality defects. (biologists.org)
  • Laterality defects are developmental disorders caused by impaired left-right patterning. (biologists.org)
  • Laterality Defects in Genome-Edited F0 myo1d Mutant Tadpoles (A) Schematic depicting Myo1d protein structure (sgRNA sites indicated). (xenbase.org)
  • To identify genetic mutations causing cardiac laterality defects. (ahajournals.org)
  • We performed a genome-wide linkage analysis in patients with cardiac laterality defects from a consanguineous family. (ahajournals.org)
  • We performed mutation analysis of NPHP4 in 146 unrelated patients with similar cardiac laterality defects. (ahajournals.org)
  • Forty-one percent of these patients also had laterality defects of the abdominal organs. (ahajournals.org)
  • Cardiac laterality defects were partially rescued by human NPHP4 mRNA, whereas mutant NPHP4 containing genetic variants found in patients failed to rescue. (ahajournals.org)
  • NPHP4 mutations are associated with cardiac laterality defects and heterotaxy. (ahajournals.org)
  • Laterality defects have been linked to ciliary motility by the observation that 48% of individuals with primary cilia dyskinesia also had situs inversus totalis and 6% had heterotaxy. (ahajournals.org)
  • The inversus viscerum ( iv ) mouse has a mutation in the ciliary left-right dynein ( lrd ) gene and often develops laterality defects. (ahajournals.org)
  • A potential molecular pathogenesis of cardiac/laterality defects in Oculo-Facio-Cardio-Dental syndrome. (xenbase.org)
  • Previous studies suggest that the suppression of Pitx2 gene in the left LPM is a potential cause of cardiac/laterality defects in Oculo-Facio-Cardio-Dental (OFCD) syndrome, which is known to be caused by mutations in BCL6 co-repressor ( BCOR ) gene. (xenbase.org)
  • These studies indicated that uncontrolled Notch activity in the left LPM caused by dysfunction of BCOR may result in cardiac/laterality defects of OFCD syndrome. (xenbase.org)
  • The term laterality refers to the preference most humans show for one side of their body over the other. (wikipedia.org)
  • This study investigated the phenomenon of lower extremity functional asymmetries in a group of competitive male distance runners ( N = 29). (humankinetics.com)
  • Data analysis revealed significant asymmetries for both lower extremity functional parameters. (humankinetics.com)
  • The laterality patterns of functional asymmetries were found to be consistent and independent of the conventional upper and lower extremity lateral preferences. (humankinetics.com)
  • 2018. The functional and structural asymmetries of the superior temporal sulcus. (uib.no)
  • Anatomical and functional asymmetries are widespread in the animal kingdom [1, 2]. (xenbase.org)
  • This excellent book celebrates Richard J. Andrew's important contributions to the study of lateralization by considering recent research exploring functional brain asymmetries in a range of vertebrate species. (cambridge.org)
  • Cognitive control processes and functional cerebral asymmetries: association with variation in the handedness-associated gene LRRTM1. (uio.no)
  • The data suggest the hemispheric laterality in the slow wave origin. (nih.gov)
  • Functional changes in inter- and intra-hemispheric cortical processing underlying degraded speech perception. (nih.gov)
  • 2000 , 2001 ) provide evidence for enhanced local processing in large-brained mammals and suggest that greater structural and functional lateralization may arise from increased intrahemispheric connections and hemispheric isolation via reduced commissural linkage. (springer.com)
  • 2012 ) would be predictive of increased hemispheric lateralization and functional independence of the cerebral hemispheres. (springer.com)
  • People with schizophrenia may show differences in handedness or footedness, as well as altered visual and auditory dominance that may reflect abnormalities in brain laterality and dominance. (edu.au)
  • As a reliable and valid measures of perceptual auditory laterality, dichotic listening has been successfully applied in studies in many countries and languages. (cambridge.org)
  • Voicing" explained 69% and 18% of the variance in the perceptual auditory laterality in the Norwegian and the Estonian sample, respectively. (cambridge.org)
  • Previous studies suggest that at poorer signal-to-noise ratios (SNRs), auditory cortical event-related potentials are weakened, prolonged, and show a shift in the functional lateralization of cerebral processing from left to right hemisphere. (nih.gov)
  • The book contains sections on animal models and basic functions, neuroimaging and brain stimulation studies, visual laterality, auditory laterality, emotional laterality, neurological disorders, and psychiatric disorders. (mit.edu)
  • 2015. Laterality and mental disorders in the postgenomic age - A closer look at schizophrenia and language lateralization. (uib.no)
  • Recognition of these functional constraints led to the hypothesis that large-brained mammals should exhibit greater structural and functional brain lateralization. (springer.com)
  • Indeed, structural, functional, and behavioral lateralization has been observed throughout the Cetacea, including both the Odontoceti (echolocating toothed whales, dolphins, and porpoises) and Mysticeti (non-echolocating baleen whales). (springer.com)
  • Functional lateralization is presumably brought about by the diversification of neuronal function on a subanatomical level, such as differential gene expression in bilaterally symmetric structures. (genetics.org)
  • To better understand change to interhemispheric interaction and cerebral laterality with age we are investigating the relationship between age-related change to brain microstructural connectivity, functional lateralization, and cognitive performance. (plymouth.ac.uk)
  • Previous research on the predatory behaviour of the scale-eating Lake Tanganyika cichlid Perissodus microlepis indicates behavioural laterality that reflects asymmetric jaw morphology. (biologists.org)
  • We investigated stomach contents and behavioural laterality of predation in aquarium to clarify the functional roles and evolution of laterality in cichlids. (biologists.org)
  • Taken together, this study provides new insights into the functional roles of behavioural laterality: predatory fish aiming for prey that show escape behaviours frequently exhibit lateralized behaviour in predation. (biologists.org)
  • This is interesting because it suggests a functional relationship between the shape of the brain and behavioural laterality", says Schneider. (eurekalert.org)
  • and functional magnetic resonance imaging for measuring changes attributable to CBF. (oup.com)
  • Differential effects of deep sedation with propofol on the specific and nonspecific thalamocortical systems: a functional magnetic resonance imagin. (nih.gov)
  • The authors studied the effect of propofol on thalamocortical functional connectivity in the specific and nonspecific systems, using functional magnetic resonance imaging. (nih.gov)
  • At the UMC he also established various lines of research, mostly using functional Magnetic Resonance Imaging. (umcutrecht.nl)
  • Effects of vision restoration training on early visual cortex in patients with cerebral blindness investigated with functional magnetic resonance imaging. (umcutrecht.nl)
  • Magnetic source imaging (MSI) or magnetoencephalography (MEG) is a non-invasive functional imaging technique in which the weak magnetic forces associated with the electrical activity of the brain are monitored externally on the scalp, i.e. (aetna.com)
  • An asymmetric or lateralized brain is characterized by anatomical or functional differences between its bilateral components, such as the cerebral hemispheres, cortical areas, or cerebral white matter tracts. (springer.com)
  • Research in the Laterality Lab is aimed at establishing how perceptual, cognitive, and motor processes are integrated between the two cerebral hemispheres of the brain. (plymouth.ac.uk)
  • Conclusions: The functional-rTMS protocol enhanced cortical excitability following a single-session and after repeated sessions and improved steadiness, whereas the passive stimulation protocol tended to decrease excitation and no improvements in steadiness were observed. (iospress.com)
  • Brain laterality in schizophrenia has been examined through the application of functional neuroimaging methods. (oup.com)
  • Recent advances in basic and clinical neuroscience provide an opportunity for focused application of functional imaging in neurobiological studies of schizophrenia. (oup.com)
  • The purpose of this study is to assess the hemodynamic changes of the PFC and discriminant analysis between schizophrenia patients and healthy controls during VFT task by utilizing functional optical topography. (spiedigitallibrary.org)
  • In others words, even in children that born with CHDs and that do not present others extracardiac laterality abnormalities, the etiology of these CHDs could arise from subtle faults in the formation of the left-right axis. (biomedcentral.com)
  • We interpret this as suggesting that normally there is linkage between cardiac and visceral organ laterality. (hindawi.com)
  • The prognosis of heterotaxy mainly depends on the cardiac malformation, which can be complex with profound functional effects, such as abnormal oxygen supply or obstructed blood flow. (biologists.org)
  • Depletion of nphp4 disrupted L-R patterning as well as cardiac and gut laterality. (ahajournals.org)
  • Here we examine the evolution and development of craniofacial morphology and laterality among Lake Tanganyika scale-eating cichlids. (biomedcentral.com)
  • 2017. Arterial spin labelling shows functional depression of non-lesion tissue in chronic Wernicke's aphasia. (uib.no)
  • An assessment conducted by the BlueCross BlueShield Technology Evaluation Center (2003) concluded that there is insufficient evidence to render conclusions regarding the effect of MSI/MEG on health outcomes for either pre-surgical localization of seizure origin or pre-surgical functional mapping. (aetna.com)
  • Thalamic functional connectivity predicts seizure onset laterality in individual TLE patients: Application of a biomarker development strategy, Neuroimage: Clinical, doi: 10.1016/j.nicl.2014.08.002. (txstate.edu)
  • Methods: Twelve stroke survivors were randomized into functional-rTMS or passive-rTMS conditions. (iospress.com)
  • The syndrome of primary ciliary dyskinesia (PCD, also known as Kartagener's syndrome or immotile cilia syndrome) is a spectrum of conditions caused by a failure of mucociliary clearance related to congenital, structural or functional ciliary abnormalities. (ersjournals.com)
  • The prevalence of laterality in nature suggests that bilateral symmetry may, in fact, be more superficial than originally thought and, while much is known about the developmental genetic basis for normal asymmetric development of the visceral organs and brain, comparatively little is known about the genetic basis of laterality in normally paired structures. (biomedcentral.com)
  • Both headache laterality and headache type interact with the degree of comorbidity with higher impairment in patients with left-sided and bilateral headaches as well as in patients with migraine or cluster headache. (frontiersin.org)
  • Functional connectivity analysis revealed the most extended language network alterations in left mesiotemporal sclerosis (involving the left temporal pole, left inferior frontal gyrus, and bilateral premotor areas). (ajnr.org)
  • Task-based activation maps (laterality indices) and functional connectivity analysis (global and connectivity strengths between language areas) were correlated with language scores. (ajnr.org)
  • Findings in the field of neuroendocrinology, which explores the functional relationships between hormones and the brain, have indicated that the release of testicular (androgens) and ovarian (estrogens) hormones during critical periods of brain development exert a profound effect on the genesis and survival of neurons in specific brain areas, resulting in sex differences in reproductive behaviors. (encyclopedia.com)
  • Differences in gcy expression patterns in the ASE neurons of C. briggsae arise from a difference in cis- regulatory elements and trans- acting factors that control ASE laterality. (genetics.org)
  • In sum, our results indicate the existence of a surprising multitude of putative chemoreceptors in the gustatory ASE neurons and suggest the existence of a substantial degree of laterality in gustatory signaling mechanisms in nematodes. (genetics.org)
  • For this purpose we study how reward circuits modulate executive function (self-control), interoception, and motivation in the normal human brain including an understanding of the role of brain dopamine signaling, functional brain network interactions and genetics. (nih.gov)
  • In these studies, genetic mutations or pharmacological blockade led to functional reorganization of the circuits, and crossed excitation was proposed to couple left-right motor rhythms in synchrony. (jneurosci.org)
  • The central aim of this research is to determine whether individual differences in age-related cognitive decline are reflected in functional reorganization in the brain, and whether these changes are mediated by the degree of structural preservation. (plymouth.ac.uk)
  • Functional findings were not explained by the extent of resection or integrity of major white matter tracts. (thejns.org)
  • Functional connectivity analysis contributes unique insight into bihemispheric remodeling processes of language networks after epilepsy surgery, with characteristic findings in left and right TLE. (thejns.org)
  • Our primary finding was increased cortical activation with increasing functional impairment. (ahajournals.org)
  • 3-7 Thus, motor control ( i.e. , the command center for movements regardless of the laterality of the effectors involved) resides in the hemisphere which handles respiration and speech at the same time. (asahq.org)
  • The functional neuroanatomy of event related potentials. (springer.com)
  • The aim of this study was to assess the relationship between the degree of unilateral spatial neglect during the acute phase of stroke and long-term functional independence. (scielo.br)
  • This was a prospective study of right ischemic stroke patients in which the independent variable was the degree of spatial neglect and the outcome that was measured was functional independence. (scielo.br)
  • The best chance of functional independence decreased with increasing star cancellation test scores (OR=0.86 [0.78-0.96], p =0.006) corrected for the stroke severity, which was a confounding factor that had a statistically negative association with independence (OR=0.66 [0.48-0.92], p =0.017). (scielo.br)
  • The severity of unilateral spatial neglect in acute stroke worsens the degree of long-term disability and functional independence. (scielo.br)
  • The main areas involved in USN are related to the right hemisphere, such as lesions in the right posterior parietal lobe ( 11 - 12 ), and individuals with USN after stroke present with major functional disabilities as well as decreased rates of adherence to rehabilitation programs ( 13 - 15 ). (scielo.br)
  • We appreciate Alves et al for their comments on our article, Effect of Right Insular Involvement on Death and Functional Outcome After Acute Ischemic Stroke in the IST-3 Trial. (ahajournals.org)
  • However, until recently, results were conflicting because most studies failed to adjust their analyses for variables known to impact on stroke death and functional outcome such as stroke severity or the volume of infarcted brain tissue. (ahajournals.org)
  • It was hypothesized that stroke laterality was a predictor. (iospress.com)
  • Stroke laterality was not associated. (iospress.com)
  • Using a large stroke cohort and a machine-learning approach, we show that visual memory and verbal memory deficits are better predicted by functional connectivity than by lesion location, and visual and motor deficits are better predicted by lesion location than functional connectivity. (pnas.org)
  • These results shed light on the complementary value of structural vs. functional accounts of stroke, and provide a physiological mechanism for general multidomain deficits seen after stroke. (pnas.org)
  • We measured resting functional connectivity (FC), lesion topography, and behavior in multiple domains (attention, visual memory, verbal memory, language, motor, and visual) in a cohort of 132 stroke patients, and used machine-learning models to predict neurological impairment in individual subjects. (pnas.org)
  • Objectives The relationship between stroke topography (ie, the regions damaged by the infarct) and functional outcome can aid clinicians in their decision-making at the acute and later stages. (bmj.com)
  • We sought to determine which brain regions are associated with good functional outcome at 3 months in patients with left-sided and right-sided stroke treated by endovascular treatment using the diffusion-weighted imaging-Alberta Stroke Program Early CT Score (DWI-ASPECTS). (bmj.com)
  • Functional optical topography (fOT), imaging based on functional near-infrared spectroscopy measurement, is an another noninvasive neuroimaging technique that provides continuous recording of brain hemodynamic activity with detection of oxy- and deoxy-hemoglobin concentration changes. (spiedigitallibrary.org)
  • Because this requires separate neural supplies to these two strands of frontalis, from a functional viewpoint this should be regarded as two not one muscle. (scholarpedia.org)
  • Continued work on the developmental genetic basis of laterality in the Perissodini will facilitate a better understanding of the evolution of this unique group of fishes, as well as of left-right axis determination among vertebrates in general. (biomedcentral.com)
  • Here we report a genetic screen to discover mutations which perturb organ laterality. (hindawi.com)
  • Finally, genetic interference experiments demonstrated a functional interaction between the core planar cell polarity signaling gene vangl2 and myo1d in LR axis formation. (xenbase.org)
  • Further, we show that the evolutionary history of the Perissodini is characterized by an accentuation of craniofacial laterality such that certain taxa show elaborate sided differences in craniofacial shape consistent with the sub-partitioning of function between sides of the head during attacks. (biomedcentral.com)
  • The method can also be applied to quantitatively assess laterality of other brain functions. (edu.au)
  • Since the early days of neuroscience, the relative merit of structural vs. functional network accounts in explaining neurological deficits has been intensely debated. (pnas.org)
  • Thus when decomposing facial behaviors, it is important to understand them from the perspective of functional, not structural anatomy (i.e., how the muscles function in a living, not dead, individual). (scholarpedia.org)
  • Based on these data, patients were categorized according to headache type and headache laterality, and their clinical characteristics were compared with tinnitus patients, who did not report comorbid headaches. (frontiersin.org)
  • As a clinical neurologist with interest in laterality of motor control, I read the review by Leffert and Schwamm 1 regarding neuroaxial anesthesia in parturients with intracranial pathology. (asahq.org)
  • Functional connectivity was determined as the temporal correlation of blood oxygen level-dependent signals with seed regions defined within the specific and nonspecific thalamic nuclei. (nih.gov)
  • Experimental paradigm and the seeding of the specific and nonspecific thalamic nuclei for functional connectivity analysis. (nih.gov)
  • The relative density and functional significance (in epileptogenesis) of thalamic projections to MTL subregions, however, remains to be determined. (semanticscholar.org)
  • The relationship between unilateral spatial neglect and functional independence was analyzed using multiple logistic regression that was corrected for confounding factors. (scielo.br)
  • In fact, in the majority of cases presenting laterality disorders, a complex heart malformation is also observed, suggesting that CHDs could be due to a laterality defect in the formation of the heart [ 7 ]. (biomedcentral.com)
  • Craniofacial laterality in the scale-eating specialist Perissodus microlepis was found to be evident early in development and exhibited a unimodal distribution, which is contrary to the adult condition where jaw laterality has been described as a discrete, bimodal antisymmetry. (biomedcentral.com)
  • Propofol conferred differential changes in functional connectivity of the specific and nonspecific thalamocortical systems, particularly in left hemisphere, consistent with the verbal nature of stimuli and task. (nih.gov)
  • Shall be consistent with any laterality information contained in Primary Anatomic Structure Modifier Sequence (0008,2230), Anatomic Region Modifier Sequence (0008,2220), and/or Laterality (0020,0060), if present. (nema.org)
  • The occipital reduction is consistent with the view that sensory processing decline is a common cause in cognitive aging, and the prefrontal increase may reflect functional compensation. (diva-portal.org)
  • These are dogs that generally survive by scavenging, raising the possibility that domesticated dogs have not maintained a fully functional repertoire of hunting behaviors. (scientificamerican.com)
  • That laterality decisions of organs may be independently perturbed, as in the Class 3 mutation, indicates that there are distinctive pathways for reception and organotypic interpretation of the global signals. (hindawi.com)
  • Pataraia et al (2005) studied the functional organization of the inter-ictal spike complex in 30 patients with mesial temporal lobe epilepsy (MTLE) using combined MEG/EEG recordings. (aetna.com)
  • While I was a Research Assistant Professor at Dartmouth I continued to test split-brain patients and broadened my research to incorporate functional MRI, electroencephalography, and diffusion-tensor imaging. (plymouth.ac.uk)
  • Approximate statistics are below: Favoring right hand: 88.2% Favoring right foot: 81.0% Favoring right eye: 71.1% Favoring right ear: 59.1% Same hand and foot: 84% Same ear and eye: 61.8% Laterality of motor and sensory control has been the subject of a recent intense study and review. (wikipedia.org)
  • Because of this functional division of the left and right sides of the body and of the space that surrounds it, the processing of information in the sensory cortices is essentially identical. (wikipedia.org)
  • Thus, one in five persons has a handedness that is the opposite for which they are wired (per laterality of command center or brainedness, as determined by reaction time study mentioned above). (wikipedia.org)
  • This volume bears witness to a groundswell of interest in brain laterality and its implications for the study of the mind. (cambridge.org)