A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum-cell type with massive infiltration of liver, spleen, and bone marrow. It infects DBA/2 and Swiss mice.
Species of GAMMARETROVIRUS, containing many well-defined strains, producing leukemia in mice. Disease is commonly induced by injecting filtrates of propagable tumors into newborn mice.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) arising during the propagation of S37 mouse sarcoma, and causing lymphoid leukemia in mice. It also infects rats and newborn hamsters. It is apparently transmitted to embryos in utero and to newborns through mother's milk.
Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues.
Virus diseases caused by the RETROVIRIDAE.
A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) isolated from spontaneous leukemia in AKR strain mice.
A myeloproliferative disorder characterized by neoplastic proliferation of erythroblastic and myeloblastic elements with atypical erythroblasts and myeloblasts in the peripheral blood.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
A curved elevation of GRAY MATTER extending the entire length of the floor of the TEMPORAL HORN of the LATERAL VENTRICLE (see also TEMPORAL LOBE). The hippocampus proper, subiculum, and DENTATE GYRUS constitute the hippocampal formation. Sometimes authors include the ENTORHINAL CORTEX in the hippocampal formation.
Changes in the amounts of various chemicals (neurotransmitters, receptors, enzymes, and other metabolites) specific to the area of the central nervous system contained within the head. These are monitored over time, during sensory stimulation, or under different disease states.
Enumerations of populations usually recording identities of all persons in every place of residence with age or date of birth, sex, occupation, national origin, language, marital status, income, relation to head of household, information on the dwelling place, education, literacy, health-related data (e.g., permanent disability), etc. The census or "numbering of the people" is mentioned several times in the Old Testament. Among the Romans, censuses were intimately connected with the enumeration of troops before and after battle and probably a military necessity. (From Last, A Dictionary of Epidemiology, 3d ed; Garrison, An Introduction to the History of Medicine, 4th ed, p66, p119)
Imaging techniques used to colocalize sites of brain functions or physiological activity with brain structures.
Insertion of viral DNA into host-cell DNA. This includes integration of phage DNA into bacterial DNA; (LYSOGENY); to form a PROPHAGE or integration of retroviral DNA into cellular DNA to form a PROVIRUS.
A member of the c-ets family of transcription factors that is preferentially expressed in cells of hematopoietic lineages and vascular endothelial cells. It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS.
Copolymer of divinyl ether and maleic anhydride that acts as an immunostimulant with antineoplastic and anti-infective properties. It is used in combination with other antineoplastic agents.
Polyacrylamide gel electrophoresis under conditions in which the components, such as PROTEINS, being separated can remain in their naturally folded state.
Retroviral proteins, often glycosylated, coded by the envelope (env) gene. They are usually synthesized as protein precursors (POLYPROTEINS) and later cleaved into the final viral envelope glycoproteins by a viral protease.
DNA sequences that form the coding region for the viral envelope (env) proteins in retroviruses. The env genes contain a cis-acting RNA target sequence for the rev protein (= GENE PRODUCTS, REV), termed the rev-responsive element (RRE).
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A genus of the family RETROVIRIDAE consisting of non-oncogenic retroviruses that produce multi-organ diseases characterized by long incubation periods and persistent infection. Lentiviruses are unique in that they contain open reading frames (ORFs) between the pol and env genes and in the 3' env region. Five serogroups are recognized, reflecting the mammalian hosts with which they are associated. HIV-1 is the type species.
DNA molecules capable of autonomous replication within a host cell and into which other DNA sequences can be inserted and thus amplified. Many are derived from PLASMIDS; BACTERIOPHAGES; or VIRUSES. They are used for transporting foreign genes into recipient cells. Genetic vectors possess a functional replicator site and contain GENETIC MARKERS to facilitate their selective recognition.
The transfer of bacterial DNA by phages from an infected bacterium to another bacterium. This also refers to the transfer of genes into eukaryotic cells by viruses. This naturally occurring process is routinely employed as a GENE TRANSFER TECHNIQUE.
The complex series of phenomena, occurring between the end of one CELL DIVISION and the end of the next, by which cellular material is duplicated and then divided between two daughter cells. The cell cycle includes INTERPHASE, which includes G0 PHASE; G1 PHASE; S PHASE; and G2 PHASE, and CELL DIVISION PHASE.
Genes that are introduced into an organism using GENE TRANSFER TECHNIQUES.
The introduction of functional (usually cloned) GENES into cells. A variety of techniques and naturally occurring processes are used for the gene transfer such as cell hybridization, LIPOSOMES or microcell-mediated gene transfer, ELECTROPORATION, chromosome-mediated gene transfer, TRANSFECTION, and GENETIC TRANSDUCTION. Gene transfer may result in genetically transformed cells and individual organisms.
Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.
Large, transmembrane, non-covalently linked glycoproteins (alpha and beta). Both chains can be polymorphic although there is more structural variation in the beta chains. The class II antigens in humans are called HLA-D ANTIGENS and are coded by a gene on chromosome 6. In mice, two genes named IA and IE on chromosome 17 code for the H-2 antigens. The antigens are found on B-lymphocytes, macrophages, epidermal cells, and sperm and are thought to mediate the competence of and cellular cooperation in the immune response. The term IA antigens used to refer only to the proteins encoded by the IA genes in the mouse, but is now used as a generic term for any class II histocompatibility antigen.
Subpopulation of CD4+ lymphocytes that cooperate with other lymphocytes (either T or B) to initiate a variety of immune functions. For example, helper-inducer T-cells cooperate with B-cells to produce antibodies to thymus-dependent antigens and with other subpopulations of T-cells to initiate a variety of cell-mediated immune functions.
Immunized T-lymphocytes which can directly destroy appropriate target cells. These cytotoxic lymphocytes may be generated in vitro in mixed lymphocyte cultures (MLC), in vivo during a graft-versus-host (GVH) reaction, or after immunization with an allograft, tumor cell or virally transformed or chemically modified target cell. The lytic phenomenon is sometimes referred to as cell-mediated lympholysis (CML). These CD8-positive cells are distinct from NATURAL KILLER CELLS and NATURAL KILLER T-CELLS. There are two effector phenotypes: TC1 and TC2.
The process by which antigen is presented to lymphocytes in a form they can recognize. This is performed by antigen presenting cells (APCs). Some antigens require processing before they can be recognized. Antigen processing consists of ingestion and partial digestion of the antigen by the APC, followed by presentation of fragments on the cell surface. (From Rosen et al., Dictionary of Immunology, 1989)
The genetic region which contains the loci of genes which determine the structure of the serologically defined (SD) and lymphocyte-defined (LD) TRANSPLANTATION ANTIGENS, genes which control the structure of the IMMUNE RESPONSE-ASSOCIATED ANTIGENS, HUMAN; the IMMUNE RESPONSE GENES which control the ability of an animal to respond immunologically to antigenic stimuli, and genes which determine the structure and/or level of the first four components of complement.
Antigenic determinants recognized and bound by the T-cell receptor. Epitopes recognized by the T-cell receptor are often located in the inner, unexposed side of the antigen, and become accessible to the T-cell receptors after proteolytic processing of the antigen.
The point or frequency at which all flicker of an intermittent light stimulus disappears.
Fusion of somatic cells in vitro or in vivo, which results in somatic cell hybridization.
The adherence and merging of cell membranes, intracellular membranes, or artificial membranes to each other or to viruses, parasites, or interstitial particles through a variety of chemical and physical processes.
Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.
Layers of protein which surround the capsid in animal viruses with tubular nucleocapsids. The envelope consists of an inner layer of lipids and virus specified proteins also called membrane or matrix proteins. The outer layer consists of one or more types of morphological subunits called peplomers which project from the viral envelope; this layer always consists of glycoproteins.
Proteins, usually glycoproteins, found in the viral envelopes of a variety of viruses. They promote cell membrane fusion and thereby may function in the uptake of the virus by cells.
A herpesvirus infection of CATTLE characterized by INFLAMMATION and NECROSIS of the mucous membranes of the upper RESPIRATORY TRACT.
A species of VARICELLOVIRUS that causes INFECTIOUS BOVINE RHINOTRACHEITIS and other associated syndromes in CATTLE.
Diseases of domestic cattle of the genus Bos. It includes diseases of cows, yaks, and zebus.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A species of RESPIROVIRUS frequently isolated from small children with pharyngitis, bronchitis, and pneumonia.
Viruses infecting man and other vertebrates.
Premature expulsion of the FETUS in animals.
The fraudulent misrepresentation of the diagnosis and treatment of disease.
A genus (and common name) in the AGAVACEAE family. It is known for SAPONINS in the root that are used in SOAPS.
Polyploidy with three sets of chromosomes. Triploidy in humans are 69XXX, 69XXY, and 69XYY. It is associated with HOLOPROSENCEPHALY; ABNORMALITIES, MULTIPLE; PARTIAL HYDATIDIFORM MOLE; and MISCARRAGES.
A plant genus of the LAMIACEAE family. It is known as a spice and medicinal plant.
Facilities or services which are especially devoted to providing palliative and supportive care to the patient with a terminal illness and to the patient's family.
4-carbon straight chain aliphatic hydrocarbons substituted with two hydroxyl groups. The hydroxyl groups cannot be on the same carbon atom.

Quantitation of Friend spleen focus-forming virus by a nine-day 59Fe assay. (1/851)

A previously described 3-day 59Fe assay for quantitation of Friend spleen focus-forming virus has been modified to produce a 200-fold more sensitive 9-day 59Fe assay. A characterization of this assay is reported here. Male BALB/c mice received intravenous injections of appropriately diluted Friend polycythemia virus (FVP); control mice received virus diluent. All mice were allowed food and water ad libitum for 6 days, and on day 6 after virus injection were fasted by removal of food but not water. On day 3 of the fast (the 9th day after virus injection) each mouse received an intraperitoneal injection of 1 muCi of 59Fe. Six hours later the mice were sacrificed and the splenic radioactivity was determined. The percent splenic incorporation of 59Fe was directly related to the logarithm of spleen focus-forming units (SFFU) of FVP injected in a range of approximately 25 to 1,000 SFFU. Using a standard FVP preparation in a dose range of 25 to 1,000 SFFU, it was possible to determine the SFFU titers of unknown samples by extrapolation of the percent splenic 59Fe incorporation to the logarithm of SFFU. SFFU titers obtained by the 9-day 59Fe assay were similar to those obtained by the enumerative-response assay. Advantages of the 9-day 59Fe assay over the enumerative-response assay include a 50-fold greater virus dose range, an easier and a more objective counting procedure, and a reduced coefficient of variation.  (+info)

FLI-1 inhibits differentiation and induces proliferation of primary erythroblasts. (2/851)

Friend virus-induced erythroleukemia involves two members of the ETS family of transcriptional regulators, both activated via proviral insertion in the corresponding loci. Spi-1/PU.1 is expressed in the disease induced by the original Friend virus SFFV(F-MuLV) complex in adult mice. In contrast, FLI-1 is overexpressed in about 75% of the erythroleukemias induced by the F-MuLV helper virus in newborn mice. To analyse the consequences of the enforced expression of FLI-1 on erythroblast differentiation and proliferation and to compare its activity to that of PU.1/Spi-1, we used a heterologous system of avian primary erythroblasts previously described to study the cooperation between Spi-1/PU.1 and the other molecular alterations observed in SFFV-induced disease. FLI-1 was found: (i) to inhibit the apoptotic cell death program normally activated in erythroblasts following Epo deprivation; (ii) to inhibit the terminal differentiation program induced in these cells in response to Epo and; (iii) to induce their proliferation. However, in contrast to Spi-1/PU.1, the effects of FLI-1 on erythroblast, differentiation and proliferation did not require its cooperation with an abnormally activated form of the EpoR. Enhanced survival of FLI-1 expressing erythroblasts correlated with the upregulation of bcl2 expression. FLI-1 also prevented the rapid downregulation of cyclin D2 and D3 expression normally observed during Epo-induced differentiation and delayed the downregulation of several other genes involved in cell cycle or cell proliferation control. Our results show that overexpression of FLI-1 profoundly deregulates the normal balance between differentiation and proliferation in primary erythroblasts. Thus, the activation of FLI-1 expression observed at the onset of F-MuLV-induced erythroleukemia may provide a proliferative advantage to virus infected cells that would otherwise undergo terminal differentiation or cell death.  (+info)

Protection against establishment of retroviral persistence by vaccination with a live attenuated virus. (3/851)

Many human viruses not only cause acute diseases but also establish persistent infections. Such persistent viruses can cause chronic diseases or can reactivate to cause acute diseases in AIDS patients or patients receiving immunosuppressive therapies. While the prevention of persistent infections is an important consideration in the design of modern vaccines, surprisingly little is known about this aspect of protection. In the current study, we tested the feasibility of vaccine prevention of retroviral persistence by using a Friend virus model that we recently developed. In this model, persistent virus can be detected at very low levels by immunosuppressing the host to reactivate virus or by transferring persistently infected spleen cells into highly susceptible mice. Two vaccines were analyzed, a recombinant vaccinia virus vector expressing Friend virus envelope protein and a live attenuated Friend virus. Both vaccines reduced pathogenic virus loads to levels undetectable by infectious center assays. However, only the live, attenuated vaccine prevented immunosuppression-induced reactivation of persistent virus. Thus, even very low levels of persistent Friend virus posed a significant threat during immunosuppression. Our results demonstrate that vaccine protection against establishment of retroviral persistence is attainable.  (+info)

Identification of a receptor-binding pocket on the envelope protein of friend murine leukemia virus. (4/851)

Based on previous structural and functional studies, a potential receptor-binding site composed of residues that form a pocket at one end of the two long antiparallel helices in the receptor-binding domain of Friend 57 murine leukemia virus envelope protein (RBD) has been proposed. To test this hypothesis, directed substitutions for residues in the pocket were introduced and consequences for infection and for receptor binding were measured. Receptor binding was measured initially by a sensitive assay based on coexpression of receptor and RBD in Xenopus oocytes, and the findings were confirmed by using purified proteins. Three residues that are critical for both binding and infection (S84, D86, and W102), with side chains that extend into the pocket, were identified. Moreover, when mCAT-1 was overexpressed, the infectivity of Fr57-MLV carrying pocket substitutions was partially restored. Substitutions for 18 adjacent residues and 11 other previously unexamined surface-exposed residues outside of the RBD pocket had no detectable effect on function. Taken together, these findings support a model in which the RBD pocket interacts directly with mCAT-1 (likely residues, Y235 and E237) and multiple receptor-envelope complexes are required to form the fusion pore.  (+info)

Contribution of virus-receptor interaction to distinct viral proliferation of neuropathogenic and nonneuropathogenic murine leukemia viruses in rat glial cells. (5/851)

The efficiency of receptor-mediated entry of pseudotyped virus carrying the surface protein (SU) of clone A8, a neuropathogenic variant of Friend murine leukemia virus (FrMLV), to rat glial cell line F10 was 1 order of magnitude greater than that of pseudotyped virus carrying SU of nonneuropathogenic FrMLV clone 57. Introduction of the gene coding for ecotropic MLV receptor on F10 cells (F10-ecoR) into SIRC cells, which are naturally resistant to FrMLV infection, also revealed the difference in receptor recognition between the A8 and the 57 viruses. Our results show that the difference in receptor utilization between A8-SU and 57-SU only partially explains the 3-order-of-magnitude difference in proliferation between A8 and 57 viruses in F10 cells.  (+info)

Tumor-induced immunosuppression. (6/851)

Three tumor systems, including a mastocytoma, plasmacytomas, and a leukemia-lymphoma were studied for their ability to modify humoral immunity to sheep erythrocytes both in vivo and in vitro. All tumors resulted in a depression of the hemolytic antibody plaque-forming cell response in susceptible mice. These studies indicated that the mechanism(s) of suppression, although not fully defined, were different for each model system investigated.  (+info)

Lymphocyte deficiencies increase susceptibility to friend virus-induced erythroleukemia in Fv-2 genetically resistant mice. (7/851)

The study of genetic resistance to retroviral diseases provides insights into the mechanisms by which organisms overcome potentially lethal infections. Fv-2 resistance to Friend virus-induced erythroleukemia acts through nonimmunological mechanisms to prevent early virus spread, but it does not completely block infection. The current experiments were done to determine whether Fv-2 alone could provide resistance or whether immunological mechanisms were also required to bring infection under control. Fv-2-resistant mice that were CD4(+) T-cell deficient were able to restrict early virus replication and spread as well as normal Fv-2-resistant mice, but they could not maintain control and developed severe Friend virus-induced splenomegaly and erythroleukemia by 6 to 8 weeks postinfection. Mice deficient in CD8(+) T cells and, to a lesser extent, B cells were also susceptible to late Friend virus-induced disease. Thus, Fv-2 resistance does not independently prevent FV-induced erythroleukemia but works in concert with the immune system by limiting early infection long enough to allow virus-specific immunity time to develop and facilitate recovery.  (+info)

Localisation of DNA topoisomerase IIalpha in mouse erythroleukemia cells. (8/851)

The presence of DNA topoisomerase IIalpha was investigated in interphase and metaphase mouse erythroleukemia (MEL) Friend-S cells, and in extracted with 25 mM lithium diiodosalicylate buffer (Lis) nuclei using indirect immunofluorescence. The results showed that DNA topoisomerase IIalpha is localised in the nuclei. In the metaphase cells, we found high concentrations of this enzyme in the mitotic chromosomes. Our results support the idea of the accumulation of DNA topoisomerase IIalpha at the end of the cell cycle. The extractions of nuclei with 25 mM Lis led to the complete depletion of DNA topoisomerase IIalpha from the residual nuclear matrix. Using a high dilution of the first antibody, we established that the high level of heterochromatin compactisation in the interphase nuclei is caused by the high concentration of DNA topoisomerase IIalpha.  (+info)

Marcelletti, J and Furmanski, P, Spontaneous regression of friend virus-induced erythroleukemia. Iii. The role of macrophages in regression. (1978). Subject Strain Bibliography 1978. 4 ...
Retroviruses can establish persistent infection despite induction of a multipartite antiviral immune response. Whether collective failure of all parts of the immune response or selective deficiency in one crucial part underlies the inability of the host to clear retroviral infections is currently uncertain. In this study, the contribution of virus-specific CD4+ T cells in resistance against Friend virus (FV) infection in the murine host is examined. The results show that the magnitude and duration of the FV-specific CD4+ T cell response is directly proportional to resistance against acute FV infection and subsequent disease. Notably, significant protection against FV-induced disease is afforded by FV-specific CD4+ T cells in the absence of a virus-specific CD8+ T cell or B cell response. Enhanced spread of FV infection in hosts with increased genetic susceptibility causes a proportional increase in the number of FV-specific CD4+ T cells required to control FV-induced disease. Thus, these results ...
As a member of the wwPDB, the RCSB PDB curates and annotates PDB data according to agreed upon standards. The RCSB PDB also provides a variety of tools and resources. Users can perform simple and advanced searches based on annotations relating to sequence, structure and function. These molecules are visualized, downloaded, and analyzed by users who range from students to specialized scientists.
TY - JOUR. T1 - Changes in RNA and protein metabolism preceding onset of hemoglobin synthesis in cultured friend leukemia cells. AU - Sherton, Corinne C.. AU - Kabat, David. PY - 1976. Y1 - 1976. N2 - We have studied the hematopoietic process which is induced by dimethyl sulfoxide (Me2SO) in the Ostertag FSD-1 line of Friend erythroleukemia (FL) cells and have observed several changes that precede the onset of hemoglobin synthesis at 48 hr. Although cellular viability, mitotic rate, and deoxyribonucleic acid content are unaffected by our induction procedure, the induced cells become progressively smaller, and by 96 hr contain only 55% as much ribonucleic acid and 60-70% as much protein as control cells. The decline in ribonucleic acid content is significant by 24 hr and affects 4S and ribosomal ribonucleic acids in a noncoordinated manner throughout the hematopoietic process. Furthermore, incorporation of radioactive uridine into the 45S precursor of ribosomal ribonucleic acid is specifically ...
Friend leukemia integration 1 transcription factor (FLI1), also known as transcription factor ERGB, is a protein that in humans is encoded by the FLI1 gene, which is a proto-oncogene. Fli-1 is a member of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F-MuLV). Fli-1 is activated through retroviral insertional mutagenesis in 90% of F-MuLV-induced erythroleukemias. The constitutive activation of fli-1 in erythroblasts leads to a dramatic shift in the Epo/Epo-R signal transduction pathway, blocking erythroid differentiation, activating the Ras pathway, and resulting in massive Epo-independent proliferation of erythroblasts. These results suggest that Fli-1 overexpression in erythroblasts alters their responsiveness to Epo and triggers abnormal proliferation by switching the signaling event(s) associated with terminal differentiation to proliferation.[citation needed] In addition to Friend erythroleukemia, proviral ...
Swiss mice injected subcutaneously with suspensions of spleen cells or an extract of spleens from mice infected with Friend virus develop resistance to subsequent intravenous inoculation of Friend virus. A single injection of either Friend virus or Friend cells induces resistance. Immunized mice display resistance when challenged 6 months after immunization and survive for at least 20 weeks after infection. Neutralization tests indicate that serum, but not lymphoid cells of resistant animals, can neutralize Friend virus. In vitro neutralization tests indicate that residence of virus within the peritoneal cavity of immune mice for 1 h sharply reduces the infective titer of the virus.. ...
We report the isolation and complete sequence of the gene encoding the rabbit erythroid-cell-specific 15-lipoxygenase (RBC 15-LOX), containing 14 exons spanning 8.0 kb. The transcription start point was mapped by S1 nuclease-protection experiments and comparison with the sequence of the RBC 15-LOX mRNA, as defined previously by primer extension experiments. The promoter contains a TATA-like motif, but no CCAAT motif in the canonical position, and lies within a CpG-rich island. Functional analysis of the immediate 5-flanking DNA by transfection experiments shows that a 150 nucleotide (nt) 5 fragment linked to the chloramphenicol acetyltransferase gene acts as a functional promoter in both erythroid and nonerythroid cell lines and responds in an erythroid-specific manner to the enhancer from the Friend murine leukaemia virus long terminal repeat, whereas a 40-nt fragment is inactive. Intron 7 contains eight copies of a 54-nt repeat containing a region with homology to the simian virus ...
Reaktivität: Fledermaus, Cat, Huhn and more. 161 verschiedene FLI1 Antikörper vergleichen. Alle direkt auf antikörper-online bestellbar!
Scher, W; Ansley, H; and Ornstein, L, Similar esterases in friend leukemia (fl) cells and mouse peritoneal macrophages (pm). Abstr. (1976). Subject Strain Bibliography 1976. 2745 ...
Infection of genetically resistant C57BL/6 mice with Friend leukemia virus resulted in a marked but transient immunodepression of the humoral immune response to sheep erythrocytes. The primary immune response to sheep erythrocytes was depressed in mice infected 1 or 3 days before challenge immunization, but no suppression was observed when the interval was greater. The suppression coincided with the time of transient viremia in the mice. The secondary immune response to sheep erythrocytes was inhibited when virus was injected within a few days before booster immunization. Induction of immunologic memory to sheep erythrocytes was also blocked in C57BL/6 mice given virus before priming with the SRBC. The immunosuppressive activity appeared due to a marked but transient effect of the virus on antibody precursor cells, as ascertained by cell transfer experiments. These observations are pertinent to the general question to the cellular site of action of immunosuppressive tumor viruses and the ...
Pilots count on friends and family to make organized aerobatic competition possible, and each contest poses a logistical challenge that requires many volunteers.
These lightweight improvements on the original design for spring loaded camming devices are great for trad, alpine, and beyond. I began my trad career on Friends, so these for me are a great system to use.
TY - JOUR. T1 - Effects of cyclic AMP on the growth of differentiating and undifferentiated friend erythroleukemic cells. AU - Rubin, Charles S.. PY - 1978/1. Y1 - 1978/1. N2 - Elevated concentrations of cyclic AMP elicit only minor reductions in growth rate and saturation density in undifferentiated Friend erythroleukemic cells. During the course of dimethylsulfoxide (DMSO)‐induced differentiation, Friend cells convert from a cyclic AMP‐tolerant state to a phenotype characterized by a high degree of sensitivity to cyclic AMP‐mediated growth arrest. Conversion to cyclic AMP sensitivity is detectable after 30 hours growth in medium containing 2% DMSO, and either 0.5 mM 8‐Br‐cyclic AMP or 5 nM cholera toxin. Cultures of differentiating Friend cells achieved a stationary phase density that was approximately 8‐fold higher than the cell density observed in parallel, differentiating cultures treated with 0.5 mM 8‐Br‐cyclic AMP. Temporally, the appearance of cyclic AMP‐sensitivity ...
The effect of neonatal infection with Friend virus (FV) and Rowson-Parr virus (RPV) on the maturation of the capacity to respond to sheep red cells, as measured by the numbers of hemolytic plaque-forming cells in the spleen, was investigated in BALB/c mice. Both viruses affected immunological maturation but there were significant differences between their effects. The development with age of the ability to produce plaque-forming cells in response to antigen was virtually abolished by FV and only slightly impaired by RPV. Furthermore, FV also suppressed the development of background plaque-forming cells, whereas RPV did not. ...
TY - JOUR. T1 - Phosphoinositide signaling in nuclei of friend cells. T2 - Tiazofurin down-regulates phospholipase C β1. AU - Manzoli, Lucia. AU - Billi, Anna Maria. AU - Gilmour, R. Stewart. AU - Martelli, Alberto Maria. AU - Matteucci, Alessandro. AU - Rubbini, Silvia. AU - Weber, George. AU - Cocco, Lucio. PY - 1995. Y1 - 1995. N2 - Previous investigations have demonstrated the presence of conventional lipid kinases and phospholipase C (PLC) activities in nuclei of Friend erythroleukemia cells. Moreover, when Friend erythroleukemia cells are treated for 96 h with the antitumor drug tiazofurin, the induction of erythroid differentiation is accompanied by changes in amounts of both phosphatidylinositol and phosphatidylinositol 4,5-bisphosphate due to the inhibition of an uncharacterized nuclear PLC activity. Here, we show that the nuclear PLC β1 isoform is down-regulated by tiazofurin (5 μM) treatment of Friend erythroleukemia cells as shown by both Western blot and Northern blot analyses ...
The suppressive capacity of regulatory T cells (Tregs) has been extensively studied and is well established for many diseases. The expansion, accumulation, and activation of Tregs in viral infections are of major interest in order to find ways to alter Treg functions for therapeutic benefit. Tregs are able to dampen effector T cell responses to viral infections and thereby contribute to the establishment of a chronic infection. In the Friend retrovirus (FV) mouse model, Tregs are known to expand in all infected organs. To better understand the characteristics of these Treg populations, their phenotype was analyzed in detail. During acute FV-infection, Tregs became activated in the spleen and bone marrow, as indicated by various T cell activation markers, such as CD43 and CD103. Interestingly, Tregs in the bone marrow, which contains the highest viral loads during acute infection, displayed greater levels of activation than Tregs from the spleen. Treg expansion was driven by proliferation but no FV
Regulatory T cells (Tregs) are immunosuppressive cells of the immune system that control autoimmune reactivity. Tregs also respond during immune reactions to infectious agents in order to limit immunopathological damage from potent effectors such as CD8+ cytolytic T lymphocytes. We have used the Friend virus (FV) model of retroviral infection in mice to investigate how viral infections induce Tregs. During acute FV infection, there is significant activation and expansion of thymus-derived (natural) Tregs that suppress virus-specific CD8+ T cell responses. Unlike conventional T cells, the responding Tregs are not virus specific, so the mechanisms that induce their expansion are of great interest. We now show that B cells provide essential signals for Treg expansion during FV infection. Treg responses are greatly diminished in B cell-deficient mice but can be restored by adoptive transfers of B cells at the time of infection. The feeble Treg responses in B cell-deficient mice are associated with ...
The murine allele temperature-sensitive (ts) p53Val-135 encodes a ts p53 protein that behaves as a mutant polypeptide at 37 degrees C and as a wild-type polypeptide at 32 degrees C. This ts allele was introduced into the p53 nonproducer Friend erythroleukemia cell line DP16-1. The DP16-1 cell line was derived from the spleen cells of a mouse infected with the polycythemia strain of Friend virus, and like other erythroleukemia cell lines transformed by this virus, it grows independently of erythropoietin, likely because of expression of the viral gp55 protein which binds to and activates the erythropoietin receptor. When incubated at 32 degrees C, DP16-1 cells expressing ts p53Val-135 protein, arrested in the G0/G1 phase of the cell cycle, rapidly lost viability and expressed hemoglobin, a marker of erythroid differentiation. Erythropoietin had a striking effect on p53Val-135-expressing cells at 32 degrees C by prolonging their survival and diminishing the extent of hemoglobin production. This response
The effects of N-5-dimethyl-9-(2-methoxy-4-methylsulfonylamino)-phenylamino-4-acridinecarboxamide (CI-921; NSC 343499), a lipophilic and water-soluble derivative of amsacrine (NSC 249992), on cell viability, growth, clonogenicity, and progression through the cell cycle were investigated in suspension cultures of Friend erythroleukemic cells and in adherent cultures of Chinese hamster ovary cells. CI-921 was less toxic toward stationary than toward exponentially growing Chinese hamster ovary cells; colony formation was inhibited by 50% following a 1-h pulse of 190 versus 80 nm CI-921, respectively. Cell viability was unaffected in Friend erythroleukemic cell cultures at concentrations up to 50 nm, although growth was inhibited by 50% following 24 h of continuous exposure to 9.5 nm or a 1 h pulse of 67.5 nm CI-921. Constant exposure of Friend erythroleukemic cells to 10 nm CI-921 slowed proliferation and resulted in prolongation of cell transit through late S and G2 phases. Higher drug ...
The invention concerns the use of a nucleotide sequence derived from all or part of the genomic RNA 5′ end of a type C retrovirus except for Friend murine leukaemia virus (FMLV) and Moloney murine leukaemia virus (MoMLV) as internal ribosome entry site or as element enabling or improving retrovirus vector packaging. The invention also concerns a vector comprising said nucleotide sequence, a viral particle generated from this vector, a cell comprising this vector or infected by the viral particle, their therapeutic use and a pharmaceutical composition containing them. The invention further concerns the use of a vector, a viral particle or a pharmaceutical composition for transfecting or infecting pluripotent stem cells.
TY - JOUR. T1 - A friend virus mutant that overcomes Fv-2rr host resistance encodes a small glycoprotein that dimerizes, is processed to cell surfaces, and specifically activates erythropoietin receptors. AU - Kozak, Susan L.. AU - Hoatlin, Maureen E.. AU - Ferro, Frank E.. AU - Majumdar, Manas K.. AU - Geib, Roy W.. AU - Fox, Mary T.. AU - Kabat, David. PY - 1993/5. Y1 - 1993/5. N2 - The env gene of Friend spleen focus-forming virus (SFFV) encodes a membrane glycoprotein (gp55) that is inefficiently (3 to 5%) processed from the rough endoplasmic reticulum to form a larger dimeric plasma membrane derivative (gp55p). Moreover, the SFFV env glycoprotein associates with erythropoietin receptors (EpoR) to cause proliferation of infected erythroblasts [J.-P. Li, A. D. DAndrea, H. F. Lodish, and D. Baltimore, Nature (London) 343:762-764, 1990]. Interestingly, the mitogenic effect of SFFV is blocked in mice homozygous for the Fv-2r resistance gene, but mutant SFFVs can overcome this resistance. Recent ...
Polyadenylated and nonpolyadenylated mRNA were prepared from polysomes and from the postribosomal supernatant of noninduced and DMSO-induced Friend cells. The mRNA preparations were translated in a wheat germ cell-free system and the in vitro synthesized proteins, fractionated by polyacrylamide gel electrophoresis, were compared by fluorography. The electrophoretic analysis shows that four preparations of poly (A) + RNA code for many different peptides and that most of these peptides are present in each of the poly (A) + RNA translation products. However, the electrophoretic patterns of these translation products differ in the relative amounts of peptides comigrating in the gel electrophoresis. After DMSO treatment, Friend cells show significative differences in the polysomal and nonpolysomal mRNA pools. With induction, globin becomes the most abundant product of the polysomal poly (A) + RNA, while the relative amounts of peptides coded by nonglobin polysomal poly (A) + RNA are reduced. In ...
The ETS gene Fli-1 is involved in the induction of erythroleukemia in mice by Friend murine leukemia virus and Ewings sarcoma in children. Mice with a targeted null mutation in the Fli-1 locus die at day 11.5 of embryogenesis with loss of vascular integrity leading to bleeding within the vascular plexus of the cerebral meninges and specific downregulation of Tek/Tie-2, the receptor for angiopoietin-1. We also show that dysmegakaryopoiesis in Fli-1 null embryos resembles that frequently seen in patients with terminal deletions of 11q (Jacobsen or Paris-Trousseau Syndrome). We map the megakaryocytic defects in 14 Jacobsen patients to a minimal region on 11q that includes the Fli-1 gene and suggest that dysmegakaryopoiesis in these patients may be caused by hemizygous loss of Fli-1 ...
Our research is aimed at understanding host responses to retroviral infections. We use mice infected with Friend murine leukemia virus as a model to study basic immunology. A special interest is in chronic infections, including how chronic infections are established and maintained and developing strategies to prevent and treat them. Using this model, we discovered that viruses can subvert the suppressive nature of regulatory T cells to evade immunological destruction by CD8+ T cells. We also use humanized mice that contain human immune systems as a model to study immune responses to HIV infection and to help us determine basic mechanisms of vaccine protection against acute and chronic retroviral infections. We are currently using this model to study possible cures for latent HIV infections and to develop new therapeutics. ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Acute Erythroblastic Leukemia (Erythroleukemias): Read more about Symptoms, Diagnosis, Treatment, Complications, Causes and Prognosis.
Thank you for your interest in spreading the word about Biochemical Society Transactions.. NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.. ...
We know the term nosy friends seems to be a contradiction. Nonetheless, they do exist. Such friends ask too many personal questions. They want to know the minutest details of your movements. They give you unsolicited advice. Such friends just dont seem to understand when to stop intruding into your life. This can be quite annoying for you. How do you deal with such a situation? There are a few tips that you can follow to handle nosy friends.. How to handle nosy friends?. Change the subject: In case someone asks a question you dont intend to answer, just change the subject and hope that the person will get the message.. Lay down the rules:. Strictly demarcate how much is too much. Tell your friend politely what kind of questions you find acceptable and what makes you uncomfortable. This will help you handle nosy friends effectively.. Silence is golden:. If you dont want to answer an intruding question, remain silent and smile.. Be stern:. Tell assertively, but not aggressively, that you ...
Best Friends Dog toys - Best Friends Dog toys, Best Friends Rabbit Dog toy Best Friends From Snack and Best Friends Pheasant Dog toy with Squeaker Best Friends Monkeez Friends Squeaky Pet Dog toy Hedgehog Best
150 My friends belonged to the popular crowd in school 1 2 3 4 Othe r students liked my friends 1 2 3 4 My teachers liked my friends 1 2 3 4 I was the leader among my group of friends 1 2 3 4 Teachers cared most about students who were going to college 1 2 3 4 Section 11: How much do you agree or disagree with the f ollowing statements about your high school friends Use the response code below for your answer. 1=strongly agree 2=agree 3=disagree 4=strongly disagree My friends are important to me 1 2 3 4 I spend as much time as possible with my friends 1 2 3 4 My friends are my family 1 2 3 4 I am involved in extracurricular activities with my friends 1 2 3 4 I have rules of friendship 1 2 3 4 If I have problems I can always count on my friends 1 2 3 4 My friends are the first ones I turn to for advice 1 2 3 4 My friends do not judge me 1 2 3 4 My friends do not make me feel bad about myself 1 2 3 4 1 2 3 4 My friends know everything about me 1 2 3 4 My friends are the only ones that understand ...
PubMed comprises more than 30 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
You agreed to meet a friend of yours at Espresso Royale some time between noon and 1pm. Unfortunately, your cell phone died and you have no way of getting in touch with your friend. Both you and your friend have a busy schedule, so you will arrive at a random moment in time distributed uniformly between 12pm and 12:45pm, wait for 15 minutes and then leave if you dont see your friend. Your friend will do the same (assume your arrival times are independent). Find the probability that you and your friend will meet.. ...
After the final straw of only drinking one beer and two shots of fireball over the entire course of a club BYO and a Kappa Psi late night, friends of Kelsey Thompson (C 21) decided it was time to step in.. Kelsey just drinks a frighteningly small amount, said a friend who wanted to remain anonymous. We didnt want to make a big deal of it at first, but its just gotten out of control. Were all really worried about her.. This past Friday night, friends of Thompson held an intervention in her 39th street apartment. Thompson entered to find a circle of her friends sitting around her coffee table. When we confronted her, she told us she was really hurt about the accusations, said close friend Jessie Merkoff. ...
Food is love. When taking food to your friend (and to the family too), ask what they would like and can eat. Use a dish that does not need to be returned. Try to help out more than once (treatment may last for months). And remember to follow basic food safety guidelines: avoid uncooked meats, seafood and eggs and be sure to wash all fruits and vegetables.. Make trips fun. Combine a required trip to the physician or therapist with a fun activity. Make arrangements to go out to lunch, stroll a mall, or do whatever he or she would like to do.. Keep your friendship a two-way street. Although you will no doubt spend time listening to your friend, talking about your own life (both good and bad) will allow your friend to feel needed and to contribute something in return.. Touch or hug your friend at every appropriate opportunity. People who are sick rarely get enough hugs. Cancer is not contagious. But please dont visit your friend if you have any symptoms of a respiratory infection, and always wash ...
I have met a sweet pen pal, who is a fellow home schooler. We have not known each other for very long, but we understand each other, and it seems as if we were long lost friends. Just this year we discovered that even our birthdays are but one day apart.. My friend has not had the easy life that I have had. Abandoned with four small children to raise, she runs a simple business in her home, with which her children, as they have aged, have had to help. They have chosen to live frugally and work at home, in exchange for the joys of being together and living in a God-fearing manner. They have little money for luxuries, yet my friend makes luxuries happen in a frugal way. I think God helps her with that.. My friend heats with firewood and really cooks real food. Because she does not have a dishwasher, the children have to wash many dishes. She also makes little crafts for people who are less fortunate than she, and works a lot at church.. The children, now in their teens, have to work outside the ...
friends, fun, tagging! Free forum : Welcome To The Best Of Friends~H Private community of long-time friends in recovery This site is for our HATR FAMILY to come to and visit with other Friends and Family. We are all about enjoying the outdoors. Hunting Target Shooting, Gun Collecting
friends are like memories.... some are short term.... ...some are long term and help define who yo ...Find answers to the question, Do You Really Make Friends Or Simply Go On Adding Friends? from people who know at Ask Experience.
Huge thanks to Erin for getting me the photos!!!. We were redeeming a Living Social deal that included dinner after trapeze. Erin and I sat at the end of the table with the rest of the Living Social peeps*, and spent most of our time talking to a young couple. I was sitting there, talking to them, enjoying our conversation SO MUCH, thinking, There are so many wonderful, interesting people in the world! I want to meet them all! I want to be friends with them all**. WANT ALL THE FRIENDS!!!. No, Kim, no. You do not need to make friends with every interesting person you meet. You dont need to chase down runners in your hood. You barely have time with your closest friends, say, take for instance, the one with you?!?! Gah, if anything, this awesome evening with Erin made me miss all the time we used to spend together when we were training for the Milwaukee Marathon. Sigh.. I just get this urge. When I meet someone and get a good feeling about them, I think I want to spend more time with them! I ...
To summarize the study, the researchers found that friends had 57% increased chance of becoming obese. The fact that two best friends were 1000 miles apart did not change the contagious effect of obesity. The research result was still valid for two friends who lived far away from each other. According to the researchers, the reason of this phenomenon is because people see their friends gain weight and become bigger thus conclude that its okay to be bigger since their surrounding network are also grow bigger ...
Daily Prompt: Imaginary Friend Many of us had imaginary friends as young children. If your imaginary friend grew up alongside you, what would his/her/its life be like today? (Didnt have one? write about a non-imaginary friend you havent seen since childhood.) The driver nosed the limo to the curb and I stepped out. It…
Im also a believer in the reason, season or lifetime thing. I remember the first time I heard somebody talk about that at a womens breakfast. I went, Thats IT!!! I finally understand!! and it really helped me to find that peace and freedom. There have been friends who were in my life for a short time, and thats okay with me now. I no longer worry about why we grew apart. I realise that we needed to, and it is okay. Of course I would quite literally DIE without the lifetime friends who I hold so dearly. Some have been my friends since Kindergarten, so thats a long time. Like, a quarter of a century! I know our friendships will last forever. Others, I dont think they will. I know they are for a season ...
I saw something on another board where this woman said, my best friends wife... And she was def talking about a man. Not a lady/lady combo. My best friends are a girl and my husband. (Seriously. I like him.) If my husband was all, Yeah, my best friend Ashley... Id be like, Yeah. Get out. Im sure some would disagree but I just dont think its a good idea. What do you think?
To always stay at home? For sure not!. Probalby not all your friends are going to that party, not everybody is busy or ocupied….some friends might just want to hang out, get a cup of coffee (or tea, or juice…) or watch a movie, do something outside.. And when I stay home all the time, it seems like I am just focusing more and more on my problem. I try to find more and more things that distract me from my tinnitus and I want to go out less and less.. Also when I really spend some quality time with friends, have great conversations, hang out with them at places that don´t make me feel uncomfortable then I feel amazing. For a short while I might even forget that my tinnitus is there, how many things it has changed for me . . .. Of course I still don´t like big groups, I can´t hear anything almost or let´s see…I just can´t follow the conversations, as there are usually more than one going on, it is noisy and my head starts to spin. But that is not necesarry, just meet up in small groups ...
Jody Olsen, PhD, MSW, explains why she turned to a friend for help following surgery and emphasizes the value of support from friends and family throughout the cancer journey. Jody also provides recommendations for friends and family members that want to help a loved one who has become diagnosed with cancer ...
FSET-865 If I Drink Home With A Female Friend After A Friends Wedding, It Changes To A W Slut And Continues To Be Fucked Until Morning | Watch JAV Online porn videos in amazing HD QUALITY! Exclusive JAV sex videos with hot Asian girls and Japan best AV Idols.
Many of us had imaginary friends as young children. If your imaginary friend grew up alongside you, what would his/her/its life be like today? (Didnt have one? write about a non-imaginary friend you havent seen since childhood.) (Thanks for inspiring this prompt, Olivia!)
Hi everyone! We are a group of 5 five friends and one of my friends says that shes broke all the time. It have reached a point that it is really annoying because whenever we are going to do something she says that she is broke and she has to check if she has the money to join, but she doesnt ha...
Is there anything worse than a friend stabbing you in the back? Heres how to tell youre a loyal friend, and how to spot the signs your friends are about to...
This is from the latest Dear Prudence on Slate.com. Dear Prudence, A close friend of mine unfortunately was diagnosed with HIV about two years ago. We are part of a circle of close gay friends. We have been extremely supportive of him, as he is young and nobody wants such a life-altering illness. He avoided dating, as well as sex dates, until he met the person who seems to be the man of his dreams. His boyfriend does not have HIV, and we figured that our friend would tell him his own
Lyrics to Youre A Friend To Me by Sister Sledge: Wanna hold you in my arms / Youre a friend to me, youre a friend to me / Wanna hold you
Can you look at someones collection of friends and to some degree see a reflection of who that person is? If someone has a lot of asshole friends would it stand to reason that this person is probably an asshole? Same with smart or funny or generous friends ...
You cant be friends with someone who gave you goosebumps when they said they loved you. You cant be friends with someone who you trusted with your whole being. You just cant.. I know you convince yourself that you can. You tell yourself youd rather live in a world where you can at least have a little piece of their heart, even if its not what you truly want. You tell yourself that youd rather be friends, than be nothing at all. Thatd youd rather talk occasionally with them, instead of ending things with silence.. But you cant have casual chats with someone who you used to want to marry. You cant have midnight strolls in the park with someone who used to kiss every damn tear away from your face. You cant have happy hour with someone who used to grab ahold of your hand and promise you forever. Forever with him didnt happen. Forever with her didnt happen. So stop thinking that friendship is going to bring it back. Stop thinking that forever is ever going to happen again.. ...
Lyrics to Family Friend by Acid House Kings: Its not that easy / She is a family friend / And family friends do not make good girlfriends
У нас вы найдете best friends перевод, видео клип и музыку в мп3 песни Виктория Джастис - my best friends brother.
She Said: Tell you friend your feelings about the guy one time, when shes not feeling shitty about herself and when things are calm. Simply state how you feel, be kind, and ask her how shes feeling.. To be a good friend, we do sometimes need to challenge those closest to us to do better for themselves. If a situation is bad for them, its good to say, I support you, but Im worried about x, y, and z factors here. But if you harp on it, youre showing her that you think shes not able to take care of herself.. I think Eli gives excellent advice below, but I will add this: We often think that women need 100% commitment to be happy, and that guys will do everything they can not to give it. But it could be that this situation works for her. Maybe she doesnt want a boyfriend 100% of the time, or 100% of the way. Maybe she wants to know theres someone there for her, and someone to have sex with, without the pressures of 100% commitment.. And it could be that she says she wants 100% from him, but ...
I have several friends on WoW who are on just about every day that Id like to group with. The problem is theyre all Alliance. What I would like to see is Ally and Horde being able to group for only dungeons and scenarios IF theyre battle.net friends. What do you guys think? Would it work? Do you think people would like it?
Paleta de sombras Monica que pertence à coleção Friends X Revolution.Uma bela paleta contendo 9 tonalidades nos tons nude, laranja e bordô, inspirada em Monica, personagem da série Friends.Recrie os looks da Monica na série, graças a essa pale
Your assumptions about the health of your fat friend may be wrong, but they also might be spot on. There is a lot of fat shaming that goes on, as if the pe
How to React when a Friend Is Being Mean Online. Chatting online has several factors. Remember that just about anyone can chat online, and you are not always fully sure whom you are talking to. When a so-called friend strangely acts mean,...
De Tkaczevski, L; De Harven, E; Friend, C (1968). "Structure and leukemogenic activity of a murine leukemia virus". Journal of ... De Harven, E; Friend, C (1966). "Origin of the viremia in murine leukemia". National Cancer Institute Monograph. 22: 79-105. ... He did pioneering research on viruses, mostly related to murine leukemia. He is former President of the Electron Microscopy ... S2CID 84594630.. Sato, Toru; Friend, Charlotte; de Harven, Etienne (1971). "Ultrastructural Changes in Friend Erythroleukemia ...
Ben-David Y, Giddens EB, Letwin K, Bernstein A (June 1991). "Erythroleukemia induction by Friend murine leukemia virus: ... of the ETS transcription factor family that was first identified in erythroleukemias induced by Friend Murine Leukemia Virus (F ... and mapping of a common proviral integration site Fli-1 in erythroleukemia cells induced by Friend murine leukemia virus". ... "Identification of a common viral integration region in Cas-Br-E murine leukemia virus-induced non-T-, non-B-cell lymphomas". ...
The Friend virus (FV) is a strain of murine leukemia virus identified by Charlotte Friend in 1957. The virus infects adult ... The Friend virus has been used for both immunotherapy and vaccines. It is a member of the retroviridae group of viruses, with ... This was achieved using recombinant vaccinia viruses expressing the gag and env genes of FV. Friend virus models showed ... including attenuated viruses, viral proteins, peptides, and recombinant vaccinia vectors expressing the Friend virus gene. In a ...
The Friend virus (FV) is a strain of murine leukemia virus. The Friend virus has been used for both immunotherapy and vaccines ... The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. ... The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. ... Rein A (2011). "Murine leukemia viruses: objects and organisms". Advances in Virology. 2011: 403419. doi:10.1155/2011/403419. ...
... a Swedish study to provide an independent investigation into the link between xenotropic murine leukemia virus-related virus ( ... Most of its funds come from private and corporate donations, and the Friends of ME Research UK Friends scheme has been set up ... "No evidence for xenotropic murine leukemia-related virus infection in Sweden using internally controlled multiepitope ...
... murine Friend leukemia virus, Rauscher leukemia virus, equine infectious anemia virus, murine immunodeficiency virus, murine ... cytomegalovirus, influentsaviirus, vesiculostomatitis virus, Sendai virus, herpesviirused, duck hepatitis B virus jt.[3] ... John's Wort Plant, in Patients with Chronic Heptatis C Virus Infection, Antimicrob Agents Chemother. 2001 February; 45(2): 517- ...
Murine leukemia virus. *Abelson murine leukemia virus. *Friend virus. *Feline leukemia virus ... Xenotropic Murine Leukemia Virus-Related Virus: Classification[citation needed] Xenotropic viruses (xenos Gr. foreign; tropos ... Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus which was first described in 2006 as an apparently novel ... "XMRV (Xenotropic Murine Leukemia Virus-related Virus) , CDC". www.cdc.gov. Retrieved 2018-04-17.. .mw-parser-output cite. ...
Murine leukemia virus. *Abelson murine leukemia virus. *Friend virus. *Feline leukemia virus ... dsDNA-RT viruses are the seventh group in the Baltimore virus classification. They are not considered DNA viruses (class I of ... Khan, Jawaid A.; Dijkstra, Jeanne (2002). Plant viruses as molecular pathogens. Psychology Press. pp. 317-. ISBN 978-1-56022- ... Retrieved from "https://en.wikipedia.org/w/index.php?title=DsDNA-RT_virus&oldid=748922731" ...
... strain of murine leukemia virus). This report attracted little interest from other researchers as the Friend leukemia virus is ... AZT proved to be a remarkably potent inhibitor of both Friend virus and Harvey sarcoma virus, and a search of the company's ... Secondary testing was performed in mouse cells infected with the retroviruses Friend virus or Harvey sarcoma virus, as the ... "Induction of endogenous virus and of thymidine kinase by bromodeoxyuridine in cell cultures transformed by Friend virus". ...
... including a report from a laboratory in showing it had activity against Friend virus, a murine virus that causes leukemia in ... Harvey sarcoma virus and Friend leukemia virus. To see if it was also active against HIV, they collaborated with scientists at ... which was found to be active against herpes simplex virus and vaccinia virus and with a lower toxicity than similar compounds. ... She also continued to look into AZT's other potential uses, including against other viruses and bacteria. In 1995, after ...
Murine leukemia virus. *Abelson murine leukemia virus. *Friend virus. *Feline leukemia virus ... Murine leukemia virus; others include Feline leukemia virus. *Genus Deltaretrovirus; type species: Bovine leukemia virus; ... Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... Such viruses are either single stranded RNA (e.g. HIV) or double stranded DNA (e.g. Hepatitis B virus) viruses. ...
In 1957 Charlotte Friend discovered the Friend virus, a strain of murine leukemia virus capable of causing cancers in ... Ludwik Gross identified the first mouse leukemia virus (murine leukemia virus) in 1951 and in 1953 reported on a component of ... Tumor viruses come in a variety of forms: Viruses with a DNA genome, such as adenovirus, and viruses with an RNA genome, like ... Not all oncoviruses are DNA viruses. Some RNA viruses have also been associated such as the hepatitis C virus as well as ...
She is best known for her discovery of the Friend leukemia virus. She helped to establish the concept of the oncovirus, studied ... "Hemoglobin Synthesis in Murine Virus-induced Leukemic Cells in Vitro: Stimulation of Erythroid Differentiation by Dimethyl ... Cemented the knowledge that virus can be responsible for some types of cancer. Friend Virus is today the model to study viral ... FRIEND C (1957). "Cell-free transmission in adult Swiss mice of a disease having the character of a leukemia". J Exp Med. 105 ( ...
A study conducted by the WPI reported in October 2009 that the so-called xenotropic murine leukemia virus-related virus was ... Whittemore was reportedly one of Reid's closest friends, and both men have characterized their relationship as close and ... Members of the Institute notably claimed in 2009 that a mouse virus was the cause of CFS. The paper was retracted following ... Boseley, Sarah (January 6, 2010). "Research casts doubt over US chronic fatigue virus claim. UK study fails to find proof of ...
Murine leukemia virus. *Abelson murine leukemia virus. *Friend virus. *Feline leukemia virus ... Murine leukemia virus; others include Feline leukemia virus. *Genus Deltaretrovirus; type species: Bovine leukemia virus; ... Feline leukemia virus and Feline immunodeficiency virus infections are treated with biologics, including the only ... "Virus Taxonomy: 2018b Release" (html). International Committee on Taxonomy of Viruses (ICTV). March 2019. Retrieved 16 March ...
Murine leukemia virus. *Abelson murine leukemia virus. *Friend virus. *Feline leukemia virus ... Caprine arthritis encephalitis virus. Visna/maedi virus. Primate lentivirus group. Human immunodeficiency virus 1. Human ... Bovine immunodeficiency virus. Jembrana disease virus. Equine lentivirus group. Equine infectious anemia virus. Feline ... Simian immunodeficiency virus. Gray mouse lemur prosimian immunodeficiency virus (pSIVgml). Lentivirus (lente-, Latin for "slow ...
... abelson murine leukemia virus MeSH B04.820.650.375.525.050 - akr murine leukemia virus MeSH B04.820.650.375.525.225 - friend ... akr murine leukemia virus MeSH B04.909.574.807.375.525.225 - friend murine leukemia virus MeSH B04.909.574.807.375.525.300 - ... akr murine leukemia virus MeSH B04.909.777.731.375.525.225 - friend murine leukemia virus MeSH B04.909.777.731.375.525.300 - ... leukemia virus, feline MeSH B04.820.650.375.510 - leukemia virus, gibbon ape MeSH B04.820.650.375.525 - leukemia virus, murine ...
Reverse transcriptase was also independently and simultaneously discovered in association with the murine leukemia virus by ... Until a more suitable laboratory could be prepared, he continued his research with RSV at a friend's laboratory at the ... In the lab, Temin studied the Rous sarcoma virus, a tumor-causing virus that infects chickens. During his research on the virus ... While studying the Rous sarcoma virus at UW-Madison, Temin began to refer to the genetic material that the virus introduced to ...
"Observations on the Repeated Administration of Viruses to a Patient With Acute Leukemia. A Preliminary Report". The New England ... weight membrane glycoproteins parallels the loss of metastatic potential in wheat-germ agglutinin-resistant Friend leukemia ... Murine respirovirus, formerly Sendai virus (SeV) and previously also known as murine parainfluenza virus type 1 or ... May 2002). "Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and ...
Baltimore extended this work and examined two RNA tumor viruses, Rauscher murine leukemia virus and Rous sarcoma virus. He went ... Foreman J (May 6, 1991). "Fraud charge leaves a career in shambles Friends contend Thereza imanish-Kari is the victim of a ' ... He tackled new problems such as the pathogenesis of Abelson murine leukemia virus (AMuLV), lymphocyte differentiation and ... Witte ON, Dasgupta A, Baltimore D (February 1980). "Abelson murine leukaemia virus protein is phosphorylated in vitro to form ...
Zúñiga's lab studies the strategies used by viruses to persist inside the host and mediate chronic infection, with a focus on T ... "Three Faculty Named Leukemia & Lymphoma Society Fellows". biology.ucsd.edu. Retrieved 3 January 2021. "Hellman Fellows » Elina ... CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells. J Immunol. 2016 Feb 15;196(4):1900-9. ... During her postdoctoral years, Zúñiga became close friends with her colleague and Global Immunotalks co-founder, Carla Rothlin ...
Feuer, G.; Chen, I. (1992). "Mechanisms of human T-cell leukemia virus-induced leukemogenesis". Biochimica et Biophysica Acta ( ... She first became interested in HIV when a close friend of hers and her fiancé's at Caltech contracted one of the first cases of ... Korber, B.; Hood, L.; Stroynowski, I. (1987). "Regulation of murine Class I genes by interferons is controlled by regions ... of defective human T-Cell leukemia virus type I proviral genomes in leukemic cells of patients with adult T-Cell leukemia". ...
Trials in numerous cancers (renal carcinoma, leukemia, lung cancer) showed that they are tolerated and safe, but on the other ... Zhao, Yijing; Niu, Chao; Cui, Jiuwei (10 January 2018). "Gamma-delta (γδ) T cells: friend or foe in cancer development?". ... Heilig JS, Tonegawa S (1986). "Diversity of murine gamma genes and expression in fetal and adult T lymphocytes". Nature. 322 ( ... such as Borrelia burgdorferi and viruses (HIV, cytomegalovirus). In most instances, the stimuli that trigger Vd1 expansion are ...
Coffin, JM; Hageman RC; Maxam AM; Haseltine WA (1978). "Structure of the Genome of Moloney Murine Leukemia Virus: A Terminally ... He worked with the American Friends Service Committee to create a resource center for those who wished to understand their own ... "Gibbon Ape Leukemia Virus Hall's Island: New Strain of Gibbon Ape Leukemia Virus". Journal of Virology. 29 (1): 395-400. doi: ... "Construction of Recombinant Retroviruses that Express the Human T Cell Leukemia Virus Type II and Human T Cell Leukemia Virus ...
McCommis KS, Baines CP (June 2012). "The role of VDAC in cell death: friend or foe?". Biochimica et Biophysica Acta (BBA) - ... structure while X-ray crystallography was used to solve murine VDAC1 (mVDAC1) structure that differs from hVDAC1 by only two ... "Critical role for voltage-dependent anion channel 2 in infectious bursal disease virus-induced apoptosis in host cells via ... induced apoptosis in Jurkat leukemia T cells". The Journal of Biological Chemistry. 280 (11): 10491-500. doi:10.1074/jbc. ...
In the presence of an infectious agent, such as bacteria, viruses, viroids, etc., the immune response of the body is to inhibit ... Fischler MP, Reinhart WH (May 1997). "[Fever: friend or enemy?]". Schweizerische Medizinische Wochenschrift (in German). 127 ( ... opposing actions of human and murine TNF-alpha and interactions with IL-beta in the rat". British Journal of Pharmacology. 118 ... particularly blood cancers such as leukemia and lymphomas; Metabolic disorders, e.g., gout, and porphyria;[citation needed] and ...
I was there with a friend musician Ali Monroe. She knew Bryan and she introduced us. We swapped phone numbers, got together a ... I just wanted to have a rant about the horrible animal cruelty in these wet-markets being the possible source of the virus, and ... Caterina Murino, Elle Macpherson, Eartha Kitt, Ray Liotta, Cindy Crawford, Tereza Maxová, Alice Sebold, Amber Valletta, Katie ... Adams donated the entire proceeds to leukemia research at a presentation at British Columbia Children's Hospital. In June 1989 ...
The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to ... The structure of the receptor-binding domain of the envelope glycoprotein from Friend murine leukemia virus was determined to ... Structure of a murine leukemia virus receptor-binding glycoprotein at 2.0 angstrom resolution.. Fass, D., Davey, R.A., Hamson, ... Friend murine leukemia virus. Mutation(s): 0 Find proteins for P03390 (Friend murine leukemia virus (isolate 57)) ...
... which includes the replication-competent ecotropic Friend murine leukemia virus (F-MuLV) and mink cell focus-forming virus (F- ... Heteroduplex mapping of molecular clones of the Friend virus complex, ... MCF) and replication-defective polycythemia- and anemia-inducing strains of spleen focus-forming virus (SFFVp and SFFVa, ... The pathogenic Friend virus complex is of considerable interest in that, although members of this group are genetically related ...
... histocompatibility complex are markedly more susceptible to erythroleukemia induction by the Friend isolate of murine leukemia ...
Friend-Murine Leukemia Virus Integration Site 3 Homolog, including: function, proteins, disorders, pathways, orthologs, and ... FIM3 (Friend-Murine Leukemia Virus Integration Site 3 Homolog) is an Uncategorized gene. ... three retroviral integration regions involved in mouse myeloblastic leukemias, are respectively located on chromosomes 6p23, ... Friend-Murine Leukemia Virus Integration Site 3 Homolog. GCID:. GC03U990033 GIFtS:. 5 ...
Friend virus;. MHC,. major histocompatibility complex;. CTL,. cytotoxic T lymphocyte;. F-MuLV,. Friend murine leukemia virus;. ... H-2a/b heterozygous mice use a hybrid molecule comprised of an Ek α chain and an Eb β chain to present a Friend murine leukemia ... For some murine leukemia viruses, type 1 T helper responses associated with specific cytokine profiles appear protective ... Friend virus infection of adult immunocompetent mice is a well established model for studying genetic resistance to infection ...
In contrast, a distinct pattern of integrated Friend murine leukemia virus copies was evident in the first non-differentiating ... Integrated Friend murine leukemia virus copies were analyzed by the Southern blotting procedure in myeloblastic cell lines ... Abstract : Integrated Friend murine leukemia virus copies were analyzed by the Southern blotting procedure in myeloblastic cell ... Monoclonal Proliferation of Friend Murine Leukemia Virus-Transformed Myeloblastic Cells Occurs Early in the Leukemogenic ...
An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor. J Virol , 65 ... Friend murine leukemia virus envelope glycoproteins bearing internal amino-terminal deletions, or a soluble 245-amino-acid gp70 ... An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor. ... An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor.. ...
The Friend virus (FV) is a strain of murine leukemia virus. The Friend virus has been used for both immunotherapy and vaccines ... The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. ... The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. ... Rein A (2011). "Murine leukemia viruses: objects and organisms". Advances in Virology. 2011: 403419. doi:10.1155/2011/403419. ...
Studies of the structure and biosynthesis of the membrane glycoproteins encoded by the Friend murine leukemia virus Public ... "Studies of the structure and biosynthesis of the membrane glycoproteins encoded by the Friend murine leukemia virus" (1981). ...
Target cell heterogeneity in murine leukemia virus infection. I. Differences in susceptibility to infection with Friend ... Target cell heterogeneity in murine leukemia virus infection. I. Differences in susceptibility to infection with Friend ... leukemia virus between B lymphocytes from spleen, bone marrow and lymph nodes. Together they form a unique fingerprint. * Sort ... leukemia virus between B lymphocytes from spleen, bone marrow and lymph nodes. ...
Friend Murine Leukemia Virus. A strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) producing leukemia of the reticulum- ... Abelson Murine Leukemia Virus. A replication-defective strain of Murine leukemia virus (LEUKEMIA VIRUS, MURINE) capable of ... Kirsten Murine Sarcoma Virus. A replication-defective murine sarcoma virus (SARCOMA VIRUSES, MURINE) capable of transforming ... mouse lymphoid cells and producing erythroid leukemia after superinfection with murine leukemia viruses (LEUKEMIA VIRUS, MURINE ...
Mouse (Murine) Friend Leukemia Virus Integration 1 (FLI1) Interaktionspartner * loss of ERG (zeige ERG Antikörper) and FLI1 ... Weitere Produktkategorien zu Friend Leukemia Virus Integration 1 Antikörper * 165 anti-Friend Leukemia Virus Integration 1 ... Weitere Antikörper gegen Friend Leukemia Virus Integration 1 Interaktionspartner. Human Friend Leukemia Virus Integration 1 ( ... Am meisten referenzierte anti-Friend Leukemia Virus Integration 1 Antikörper. Show all anti-Friend Leukemia Virus Integration 1 ...
Xenotropic Murine Leukemia Virus-Related Retrovirus: CCR Assay Development. XMRV Publications - the Debate Continues. Source: ... Xenotropic Murine Leukemia Virus-Related Retrovirus: CCR Assay Development Like. Share. Report. 109 Views ... Xenotropic Murine Leukemia Virus-Related Retrovirus: CCR Assay Development. XMRV Publications - the Debate Continues. Source: ... Xenotropic Murine Leukemia Virus-Related Retrovirus: CCR Assay Development - . xmrv publications - the debate ...
2001) Modular organization of the Friend murine leukemia virus envelope protein underlies the mechanism of infection. Proc Natl ... 1998) Moloney murine leukemia virus envelope protein subunits, gp70 and Pr15E, form a stable disulfide-linked complex. J Virol ... 2008) Stabilization of TM trimer interactions during activation of moloney murine leukemia virus Env. J Virol 82(5):2358-2366. ... 2007) The conserved His8 of the Moloney murine leukemia virus Env SU subunit directs the activity of the SU-TM disulphide bond ...
Murine Leukemia Virus-Induced Tumors by J. Virol, W Chen, H Qin, B Chesebro, M A Cheever, Shared Friend , 1996 ... Murine Leukemia Viruses by Interactions Of Murine Apobec, Human Apobecg, John M. Coffin, David Derse, Alan Rein , 2007 ... murine leukemia virus enhancer. T lymphocytes that interact with the Moloney Identification of ETS domain proteins in murine ... murine leukemia virus enhancer. T lymphocytes that interact with the Moloney Identification of ETS domain proteins in murine ...
Cellular tropism and localization in the rodent nervous system of a neuropathogenic variant of Friend murine leukemia virus. ... pol sequences from nondefective Friend murine leukemia virus. J. Virol. 64:1648-1656. ... Thymotropism of murine leukemia virus is conferred by its long terminal repeat.Proc. Natl. Acad. Sci. USA 80:4203-4207. ... A few murine leukemia viruses (MuLVs) (e.g., Cas-Br-E and ts-1) are neurovirulent and induce spongiform myeloencephalopathy, ...
A classification of the murine leukemia viruses. Neutralization of pseudotypes of Friend spleen focus-forming virus by type- ... Semliki forest virus (SFV), venezuelan equine encephalitis virus (VEEV), ross river virus (RRV), and sindbis virus ... γ-retroviral ENVs such as mouse leukemia virus amphotropic (MLV-A), gibbon ape leukemia virus (GALV), and feline endogenous ... but not murine leukemia virus, vectors mediate high efficiency gene transfer into freshly isolated G0/G1 human hematopoietic ...
A central role of CD4+ T cells emerged from studies of immunity against FMR (Friend, Moloney, Rauscher)1 murine leukemia virus ... Moloney murine sarcoma and leukemia virus complex; MuLV, murine leukemia virus; n.s., not significant. ... 1989) FBL-reactive CD8 cytotoxic and CD4 helper T cells recognize distinct Friend murine leukemia virus-encoded antigens. J Exp ... Moloney murine sarcoma and leukemia virus complex (MoMSV) was prepared and injected in the left thigh intramuscularly for ...
Genetic study of lymphoma induction by Friend murine leukemia virus in crosses involving AKR mice. ... Genes affecting mink cell focus-inducing (MCF) murine leukemia virus infection and spontaneous lymphoma in AKR F1 hybrids. ...
70 from polytropic Friend mink cell focus-inducing virus and glycoprotein 71 from ecotropic Friend murine leukemia virus, as ... Characterization of mouse monoclonal antibodies specific for Friend murine leukemia virus-induced erythroleukemia cells: Friend ... 1983) Nucleotide sequence of the envelope gene of Friend murine leukemia virus. J. Virol. 45:1-9. ... 1991) Molecular domains involved in oligomerization of the Friend murine leukemia virus envelope glycoprotein. Virology 185:710 ...
Upgrading to the Friend membership gives you access to unlimited rows of Cumulative Knowledge data. ... 3 Abstracts with Murine Leukemia Virus Research. Filter by Study Type. Animal Study. ... Diseases : Immune Dysregulation: TH1/TH2 imbalance, Immunologic Deficiency Syndromes, Murine Leukemia Virus ... Curcuma longa L and purple sweet potato had a positive effect on immunomodulation in C57BL/6 mice induced by LP-BM5 leukemia ...
Upgrading to the Friend membership gives you access to unlimited rows of Cumulative Knowledge data. ... Ecotropic murine leukemia viruses (E-MLV), Virus: Xenotropic murine leukemia virus-related virus (XMRV), Xenotropic murine ... Ecotropic murine leukemia viruses (E-MLV), Prostate Cancer, Xenotropic murine leukemia virus (X-MLV), Xenotropic murine ... 2 Abstracts with Xenotropic murine leukemia virus (X-MLV) Research. Filter by Study Type. Commentary. ...
De Tkaczevski, L; De Harven, E; Friend, C (1968). "Structure and leukemogenic activity of a murine leukemia virus". Journal of ... De Harven, E; Friend, C (1966). "Origin of the viremia in murine leukemia". National Cancer Institute Monograph. 22: 79-105. ... He did pioneering research on viruses, mostly related to murine leukemia. He is former President of the Electron Microscopy ... S2CID 84594630.. Sato, Toru; Friend, Charlotte; de Harven, Etienne (1971). "Ultrastructural Changes in Friend Erythroleukemia ...
The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine ... and Friend murine leukemia virus envelope proteins (Earl, P. L. et al, Science, 234:728-731 (1986)). A vaccinia based viral ... Temperature-resistant viruses are superior to temperature-sensitive viruses as modified live virus vaccines because (1) ... Virus yield (p.f.u.) of virus when plaque titrated at:Virus growth 34.5 C. 39.1 C.______________________________________IBRV( ...
In the first stage of Friend disease, constitutive activation of EPOR by gp55 causes uncontrolled, polyclonal proliferation of ... It is encoded by the defective env gene of the virus.. The Friend murine leukemia virus complex induces a rapid and fatal ... The second component is a replication competent Friend murine leukemia virus (F-MuLV) that serves as a helper virus for SFFV. ... Friend spleen focus-forming virus (isolate 502) (FSFFV). Friend spleen focus-forming virus (FSFFV). Mus musculus (Mouse). ...
... isolated as a potent inducer of differentiation in murine erythroleukemia cells, caused reversible arrest of rat 3Y1 fibroblast ... Erythrocytic maturation in vitro of murine (Friend) virus-induced leukemia cells, Natl. Cancer Inst. Monogr., 228, 505-520. ... a specific inhibitor of mammalian cell cycle with potent differentiation-inducing activity in Friend leukemia cells, J. ... Yoshida, M., Iwamoto, Y., Uozumi, T., and Beppu, T. (1985) Trichostatin C, a new inducer of differentiation of Friend leukemic ...
DNA-protein interactionsMyeloid leukemiaLeukemiaBiochemistry. 6. Friend murine leukemia virus-immortalized myeloid cells are ... LeukemiaLeukemia--TreatmentDrug resistance in cancer cellsGene fusionGenetics. 5. Chromosomal translocation t(15;17) in human ... GeneticsHuman chromosome abnormalities--DiagnosisLeukemia. 3. Genetic Polymorphisms of XRCC1 and Leukemia Risk: A Meta-Analysis ... CytogeneticsAdult T-cell leukemiaHTLV-I infectionsLeukemiaLymphomasCohort analysis. ...
Friend murine leukemia virus carrying the envL128I epitope induced significantly higher numbers of env-reactive EF4.1 CD4+ T ... FBL-reactive CD8+ cytotoxic and CD4+ helper T lymphocytes recognize distinct friend murine leukemia virus-encoded antigens. J ... T cell response to model retroviral antigen from the gp70 envelope glycoprotein of the Friend murine leukemia virus (F-MLV) (28 ... The Friend virus (FV) used in this study was a retroviral complex of a replication-competent B-tropic F-MLV (F-MLV-B) and a ...
Thesis Title: Genetic and Microenivronmental Effects on Friend Murine Leukemia Virus-Induced Erythroleukemia. Date & Time: ... Functions of Novel Ligand-Independent Flt3 Alleles and RANKL in Promoting Dissemination of Murine B-Cell Leukemias to Central ... Thesis Title: Development of Mouse Models of Measles Virus Infection: Role of the Innate Immune System. Date & Time: Friday, ... Thesis Title: Characterization of an IL-12-driven anticancer response, and the CD4+ CTL population incited, in a murine model ...
Moreover, they are potent inhibitors of spleen focus formation by Friend murine leukemia virus in mice. Both in cell cultures ... Inhibition of Murine Leukemia Virus Replication in Cell Culture and Spleen Focus Formation in Mice by Polyadenylic Acids. S. K ... Inhibition of Murine Leukemia Virus Replication in Cell Culture and Spleen Focus Formation in Mice by Polyadenylic Acids. S. K ... Inhibition of Murine Leukemia Virus Replication in Cell Culture and Spleen Focus Formation in Mice by Polyadenylic Acids. S. K ...
  • We studied this question with the Moloney murine leukemia virus Env, for which activation can be followed by surface (SU)-transmembrane (TM) intersubunit disulfide isomerization and subsequent SU release. (pnas.org)
  • Here we have studied how the protomeric units of Moloney murine leukemia virus envelope protein (Env) are activated in relation to each other, sequentially or simultaneously. (pnas.org)
  • mA3) and human APOBEC3G (hA3G) upon Moloney murine leukemia virus (MLV). (psu.edu)
  • Poly(adenylic acid), poly(2'- O -methyladenylic acid), and poly(2'- O -ethyladenylic acid) moderately inhibit the synthesis of Moloney murine leukemia virus in cultured JLS-V9 cells. (aspetjournals.org)
  • Retrovirus vectors such as those based on Moloney mouse leukemia virus (MLV) were amongst the first to be engineered [ 1 ]. (hindawi.com)
  • CTL directed against the Moloney murine leukemia virus (MuLV) epitope SSWDFITV recognize Moloney MuLV-induced tumor cells, but do not recognize cells transformed by the closely related Friend MuLV. (jimmunol.org)
  • The potential Friend MuLV epitope has strong sequence homology with Moloney MuLV and only differs in one amino acid within the CTL epitope and one amino acid just outside the epitope. (jimmunol.org)
  • Proteasome-mediated digestion analysis of a synthetic 26-mer peptide derived from the Friend sequence shows that cleavage takes place predominantly C-terminal of D, instead of V as is the case for the Moloney MuLV sequence. (jimmunol.org)
  • Precise identification of endogenous proviruses of NFS/N mice participating in recombination with moloney ecotropic murine leukemia virus (MuLV) to generate polytropic MuLVs. (springer.com)
  • These values were substantially smaller than the outer dimensions of the C-type murine viruses, Friend leukemia virus (FLV), namely, 1470 Å, and Moloney leukemia virus, namely, 1460 Å. (aacrjournals.org)
  • 1990 ) Sequence-specific DNA binding of the protooncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. (biologists.org)
  • The invention concerns the use of a nucleotide sequence derived from all or part of the genomic RNA 5′ end of a type C retrovirus except for Friend murine leukaemia virus (FMLV) and Moloney murine leukaemia virus (MoMLV) as internal ribosome entry site or as element enabling or improving retrovirus. (google.ca)
  • ZASC1 is a zinc finger-containing transcription factor that was previously shown to bind to specific DNA binding sites in the Moloney murine leukemia virus (Mo-MuLV) promoter and is required for efficient viral mRNA transcription (J. Virol. (biomedcentral.com)
  • This antigen is present also in ether-treated preparations of the Friend, Moloney, and Rauscher leukemia viruses, but not in Bittner (mammary tumor) virus. (rupress.org)
  • The activity of the membrane fusion protein Env of Moloney mouse leukaemia virus is controlled by isomerization of the disulphide that couples its transmembrane (TM) and surface (SU) subunits. (embopress.org)
  • Interview of Dr. John Moloney, Head, Special Viruses Cancer Program of the National Cancer Institute (NCI)' 21.2.1995 Arbeit mit Krebsviren 1947. (50g.com)
  • 82, 1597-1600), the Moloney murine leukaemia virus (Mangeney and Heidmann. (allindianpatents.com)
  • Results with chimeric MuLV constructed with genes from parental virulent and avirulent MuLVs have established that the envelope ( env ) gene of these viruses harbors the major determinant of neurovirulence ( 23 , 39 , 75 , 77 , 85 , 89 , 90 , 92 , 98 ) (reviewed in reference 91 ). (asm.org)
  • Transfer of purified polyclonal T cells from FBL (Friend MuLV-induced erythroleukemia cell line) vaccinated mice in naive animals can protect these mice against subsequent tumor challenge. (rupress.org)
  • The second component is a replication competent Friend murine leukemia virus (F-MuLV) that serves as a helper virus for SFFV. (uniprot.org)
  • Murine leukemia viruses (MuLV) and human T-cell leukemia viruses (HTLV) are phylogenetically highly divergent retroviruses with distinct envelope fusion properties. (cnrs.fr)
  • We now show that failure to recognize Friend MuLV-transformed tumor cells is based on a defect in proteasome-mediated processing of the Friend epitope which is due to a single amino acid substitution (N→D) immediately flanking the C-terminal anchor residue of the epitope. (jimmunol.org)
  • The ecotropic endogenous Murine Leukemia Virus (MuLV) also encodes TAAs from both gp70 (SU) and p15E (TM) proteins of the env gene. (pubmedcentralcanada.ca)
  • Analysis of the participation of individual T cell populations in the elimination of the Friend murine leukemia virus (MuLV)-induced tumor FBL-3, revealed that tumor-specific CD4 + T cells can also exert their effect independently of CD8 + CTLs. (rupress.org)
  • RESULTS: In the Friend retrovirus mouse model, immunization with a plasmid encoding the Friend murine leukemia virus (F-MuLV) Leader-Gag protein resulted in induction of a strong GagL -specific CD8 T cell response, while the response was completely abrogated by co-immunization with an F-MuLV Env-encoding plasmid. (bireme.br)
  • Indeed, Mo-MuLV infection of neonatal mice revealed that ZASC1 is required for efficient early virus replication in the bone marrow, but not in the thymus or spleen. (biomedcentral.com)
  • Hemolytic anemia and erythroleukemia, two distinct pathogenic effects of Friend MuLV: mapping of the effects to different regions of the viral genome. (nih.gov)
  • Two different pathogenic effects of the Friend ecotropic murine leukemia virus (F-MuLV) were distinguished by serial examinations of hematocrits and reticulocyte counts of IRW mice inoculated as newborns. (nih.gov)
  • Using strains of Friend-MuLV with different virulences, we constructed recombinant viruses that allowed us to map the hemolytic effect and the ability to induce rapid erythroleukemia to different regions of the viral genome. (nih.gov)
  • A microtechnique for an indirect viable cell membrane immunofluorescence titration assay was developed using Friend murine leukemia virus (F MuLV) producing cells and nonspecific rabbit antisera to F MuLV structural antigens. (utmb.edu)
  • Mouse APOBEC3 (mA3) inhibits murine leukemia virus (MuLV) replication by a deamination-independent mechanism in which the reverse transcription is considered the main target process. (prolekarniky.cz)
  • Mice homozygous for the H-2{dollar}\sp{lcub}d{rcub}{dollar} haplotype at the major histocompatibility complex are markedly more susceptible to erythroleukemia induction by the Friend isolate of murine leukemia retrovirus (FV) than congenic mice homozygous for the H-2{dollar}\sp{lcub}b{rcub}{dollar} haplotype. (yu.edu)
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Friend virus infection of adult immunocompetent mice is a well established model for studying genetic resistance to infection by an immunosuppressive retrovirus. (pnas.org)
  • This review summarizes studies from the polycythemia-inducing strain of Friend virus (FV) complex, an immunosuppressive retrovirus model that induces leukemia in mice. (pnas.org)
  • When adult mice of susceptible strains are infected with FV, their spleens rapidly enlarge because of virus-induced polyclonal proliferation of erythroid precursor cells ( 19 - 21 ). (pnas.org)
  • Some murine leukemia viruses (MuLVs), among them Cas-Br-E and ts -1 MuLVs, are neurovirulent, inducing spongiform myeloencephalopathy and hind limb paralysis in susceptible mice. (asm.org)
  • Curcuma longa L and purple sweet potato had a positive effect on immunomodulation in C57BL/6 mice induced by LP-BM5 leukemia retrovirus infection. (greenmedinfo.com)
  • He was subsequently hired by Memorial Sloan-Kettering Cancer Center, where he worked alongside Charlotte Friend and studied viruses, mostly in mice systems and the causation and incidence of leukemia and other malignant diseases related to those viruses. (wikipedia.org)
  • The Friend murine leukemia virus complex induces a rapid and fatal erythroleukemia in adult mice. (uniprot.org)
  • It is the replication-defective spleen focus-forming virus (SFFV) contained in this complex that causes foci of proliferating erythroid cells in spleens of infected mice. (uniprot.org)
  • Moreover, they are potent inhibitors of spleen focus formation by Friend murine leukemia virus in mice. (aspetjournals.org)
  • In 1956, Dr. Friend gave a paper at the annual meeting of the American Association for Cancer Research in which she stated that she had discovered a virus that caused a leukemia-like disorder in newborn mice. (mssm.edu)
  • T cell receptor transgenic mice (TCR GAG ) were engineered with CD8 T cells specific for the Friend murine leukemia virus (FMuLV) GAG epitope, an immunodominant antigen from the FMuLV-transformed mouse leukemia cell line, FBL (fig. S1A). (sciencemag.org)
  • Two unusual murine lymphomas, designated CH1 and CH2, were produced in the newly developed double congenic strain of mice, B 10 H-2(a)-H-4(b)p/Wts. (elsevier.com)
  • Mice that were immunized with plasmids encoding Leader-Gag and Env and the cytokines IL1 , IL12, IL15, IL28A or GM-CSF, but not Leader-Gag and Env without any cytokine, showed significantly reduced viral loads upon a high-dose Friend virus challenge infection. (bireme.br)
  • Leukemias can be induced in W/Fu inbred rats by neonatal inoculation of normal thymus cells of C58 mice. (rupress.org)
  • These leukemias are not transplantable to C58 mice or to adult W/Fu rats, but they can be kept in passage in W/Fu rats aged 0 to 7 days. (rupress.org)
  • Analysis based on the cytotoxic test indicates the presence of 2 distinct cell surface antigens in leukemias induced by Passage A Gross virus or occurring spontaneously in mice of high-incidence strains. (rupress.org)
  • A mouse leukemia virus named the Friend virus was grown in tissue culture and used to infect two mice from each of the three MHC types. (thefreedictionary.com)
  • [6] Murine refers to the rodent family Muridae , which includes common household rats and mice. (wikipedia.org)
  • The function of Cip/Kip proteins p21(Cip1) and p27(Kip1) during erythropoietin-induced terminal differentiation of primary erythroblasts isolated from the spleens of mice infected with the anemia-inducing strain of Friend virus was investigated. (elsevier.com)
  • Mice infected with the polycythemia-inducing strain of Friend virus complex (FVC-P) develop a fatal erythroid disease similar in some respects to leukemia. (elsevier.com)
  • Six- to eight-week-old DBA/2 female mice were injected i.v. with 0.5 ml of a virus suspension containing approximately 5 x 10 4 plaque-forming units and 5 x 10 3 spleen focus-forming units. (elsevier.com)
  • We use mice infected with Friend murine leukemia virus as a model to study basic immunology. (nih.gov)
  • Chattopadhyay SK, Baroudy BM, Holmes KL, Frederickson TN, Lander MR, Hartley HCM Ill, Hartley JW (1989) Biological and molecular genetic characteristics of a unique MCF virus that is highly leukemogenic in ecotropic virus-negative mice. (springer.com)
  • Expanded regulatory T cells in chronically friend retrovirus-infected mice suppress immunity to a murine cytomegalovirus superinfection. (helmholtz-hzi.de)
  • 95, 15 14920-14925) showed that murine tumoral cells from C57BL/6 strain, expressing a retroviral envelope protein, form tumours when injected in Balb/c mice (allograft), whereas the same cells, which do not express the retroviral envelope protein, are rejected. (allindianpatents.com)
  • An amino-terminal fragment of the Friend murine leukemia virus envelope glycoprotein binds the ecotropic receptor. (ucl.ac.uk)
  • We have used this property to investigate the receptor binding capacities of deleted or truncated murine leukemia virus ecotropic envelope glycoproteins. (ucl.ac.uk)
  • The susceptibility of these cells to ecotropic and amphotropic virus infection was determined. (ucl.ac.uk)
  • We observed that both membrane-bound and soluble forms of the gp70 245-amino-acid amino-terminal domain induced resistance to ecotropic virus, indicating that this fragment binds the ecotropic receptor. (ucl.ac.uk)
  • To investigate the immunogenic potential of apoptotic cells in vivo, we used the highly tumorigenic (minimal tumorigenic dose: 10 3 cells) Rauscher virus-induced H-2 b T cell lymphoma RMA ( 8 , 9 ). (jimmunol.org)
  • The residues in the helical region, but not in the beta sandwich, are highly variable among mammalian C-type retroviruses with distinct tropisms, indicating that the helical subdomain determines the receptor specificity of the virus. (rcsb.org)
  • The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
  • The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. (wikipedia.org)
  • As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
  • A paradigm for virus-host coevolution: sequential counter-adaptations between endogenous and exogenous retroviruses. (springer.com)
  • Simian foamy viruses (SFVs) are retroviruses present in nearly all nonhuman primates (NHPs), including Old World primates (OWP) and New World primates (NWP). (bireme.br)
  • Simian foamy viruses (SFVs) constitute a third group of complex retroviruses. (deepdyve.com)
  • The invention especially concerns the field of viral or retroviral infections, including the field of endogenous retroviruses, and provides means for the design of agents for the prophylaxis and/or treatment of hosts susceptible to such viruses or retroviruses, including animal or human hosts. (allindianpatents.com)
  • Polypeptides of the invention can especially be used in the generation of immunogenic compositions and in the production of attenuated viruses, for use in methods for prophylaxis and/or treatment of viral infections or their detrimental consequences or for prophylaxis and/or treatment of the detrimental consequences of the induction of expression of endogenous retroviruses (ERV). (allindianpatents.com)
  • Normal DBA/2 mouse cells synthesize a glycoprotein which interferes with MCF virus infection. (springer.com)
  • Oligosaccharides at individual glycosylation sites in glycoprotein 71 of Friend murine leukemia virus. (expasy.org)
  • Apparent identity to a major locus described for resistance to friend murine leukemia virus. (jax.org)
  • MLVs include both exogenous and endogenous viruses. (wikipedia.org)
  • The genomes of exogenous and endogenous murine leukemia viruses have been fully sequenced. (wikipedia.org)
  • Cloning of a new murine endogenous retrovirus, MuERV-L, with strong similarity to the human HERV-L element and with a gag coding sequence closely related to the Fv1 restriction gene. (springer.com)
  • B cells are essential for murine mammary tumor virus transmission, but not for presentation of endogenous superantigens. (springer.com)
  • Identification of a cellular cofactor required for infection by feline leukemia virus. (springer.com)
  • Since moderate risk tumor viruses, such as recently discovered primate oncornaviruses or feline leukemia virus (FeLV), may be hazardous to laboratory personnel, the assay was adapted for containment of cells infected with such viruses. (utmb.edu)
  • Raltegravir inhibits murine leukemia virus: implications for chronic fatigue syndrome? (virology.ws)
  • A competition radioimmunoassay directed against the gp71 group-specific antigen of Friend leukemia virus has shown that there is a murine leukemia virus associated with these tumors, however, we have been unable to establish a causal relationship between the virus and this malignancy. (elsevier.com)
  • With the assumption that T cells might be able to recognize and eliminate cancer cells with the same efficiency as virus-infected cells, investigators have searched many years for ways to trigger or amplify the patient's inadequate immune response to tumors. (rupress.org)
  • However, the absence of ZASC1 did not influence the timing of subsequent tumor progression or the types of tumors resulting from virus infection. (biomedcentral.com)
  • Clinical Signs and Blood Test Results Among Humans Infected With Zoonotic Simian Foamy Virus: A... Buseyne, Florence;Betsem, Edouard;Montange, Thomas;Njouom, Richard;Ndongo, Chanceline Bilounga;Hermine, Olivier;Gessain, Antoine 2018-03-28 00:00:00 Abstract Background A spillover of simian foamy virus (SFV) to humans, following bites from infected nonhuman primates (NHPs), is ongoing in exposed populations. (deepdyve.com)
  • Encrypted proteins are trafficked to the plasma membrane, where they are combined into progeny virus particles. (wikipedia.org)
  • Experiments have shown that it is possible to protect against Friend virus infection with several types of vaccines, including attenuated viruses, viral proteins, peptides, and recombinant vaccinia vectors expressing the Friend virus gene. (wikipedia.org)
  • The viral class I membrane fusion proteins, such as those of the influenza, retro, paramyxo, corona, and Ebola viruses, are typically trimeric transmembrane proteins, where the protomeric unit is composed of a transmembrane subunit (TM) and a peripheral subunit. (pnas.org)
  • In murine leukemia virus (MLV) maturation, Gag is cleaved at three sites, resulting in formation of the matrix (MA), p12, capsid (CA), and nucleocapsid (NC) proteins. (pubmedcentralcanada.ca)
  • This conversion to an infectious particle is brought about by the cleavage of viral proteins by the virus-encoded protease (PR). (pubmedcentralcanada.ca)
  • 10 In vivo tests demonstrated that inactivated viruses, as well as synthetic peptides similar to retrovirus envelope proteins have immunosuppressive properties (Oostendorp et al. (allindianpatents.com)
  • Heteroduplex analysis of molecular clones of the pathogenic Friend virus complex: Friend murine leukemia virus, Friend mink cell focus-forming virus, and the polycythemia- and anemia-inducing strains of Friend spleen focus-forming virus. (semanticscholar.org)
  • 3 CONFWENTIEL human immunodeficiency virus 1 (HIV-1) and the human T-cell leukaemia virus type 1 (HTLV-1). (allindianpatents.com)
  • Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
  • Monoclonal Proliferation of Friend Murine Leukemia Virus-Transformed Myeloblastic Cells Occurs Early in the Leukemogenic Process. (archives-ouvertes.fr)
  • In contrast, a distinct pattern of integrated Friend murine leukemia virus copies was evident in the first non-differentiating immature myeloblastic cells appearing in cultures, suggesting a monoclonal origin of these cells. (archives-ouvertes.fr)
  • Friend murine leukemia virus envelope glycoproteins bearing internal amino-terminal deletions, or a soluble 245-amino-acid gp70 amino-terminal fragment, were expressed in NIH 3T3 cells. (ucl.ac.uk)
  • or amphotropic (wild mouse viruses capable of infecting both mouse and heterologous species cells). (psu.edu)
  • This study shows that induction of tumor-specific CD4 + T cells by vaccination with a specific viral T helper epitope, contained within a synthetic peptide, results in protective immunity against major histocompatibility complex (MHC) class II negative, virus-induced tumor cells. (rupress.org)
  • Indeed, retrovirus-based gene transfer strategies utilize vectors pseudotyped with the amphotropic murine leukemia retrovirus (MLV) envelope because of the presence of the amphotropic receptor on human cells. (asm.org)
  • Natural antibodies directed against murine lymphosarcoma cells. (nih.gov)
  • While at Sloan-Kettering, de Harven was part of a team which discovered "virus-like particles" in cells taken from patients suffering from Hodgkin's disease. (wikipedia.org)
  • 4) selecting or screening, in tk - IBRV host cells, for tk - IBRV from the virus produced in step (3) so as to produce an infectious bovine rhinotracheitis virus mutant which fails to produce any functional thymidine kinase as a result of an insertion in the IBRV tk gene. (google.com.au)
  • In the first stage of Friend disease, constitutive activation of EPOR by gp55 causes uncontrolled, polyclonal proliferation of infected erythroblasts, leading to polycythemia (massive increase in the number of mature red cells). (uniprot.org)
  • Trichostatin A (TSA), isolated as a potent inducer of differentiation in murine erythroleukemia cells, caused reversible arrest of rat 3Y1 fibroblast proliferation in G1 and G2 phases without any inhibition of macromolecular synthesis. (springer.com)
  • Indeed, the ratio of Tfh to Th1 cells in the CD4 + T cell response to acute lymphocytic choriomeningitis virus (LCMV) has been amply reported close to 1 and 2 for LCMV Armstrong ( 9 - 14 ) and clone 13 (Cl13) ( 15 - 19 ), respectively, and similar results were also reported for influenza A virus infection ( 20 - 23 ). (frontiersin.org)
  • Several well-defined factors have been demonstrated to influence the balance of Th1 and Tfh cells in response to viruses, as well as other challenges. (frontiersin.org)
  • Viruses are obligate intracellular parasites which have evolved to transfer their genetic material to infected cells and use their biosynthetic machinery to replicate, encapsidate, and package their genome. (hindawi.com)
  • Virus particles are usually secreted so they can infect neighbouring cells and start a new infectious cycle. (hindawi.com)
  • The discovery that viruses could also incorporate and transmit genes of cellular origin opened the possibility of using them as tools to genetically modify cells. (hindawi.com)
  • On the other hand, dendritic cells (DCs) pulsed with apoptotic monocytes activated in vitro virus-specific CTLs ( 6 ). (jimmunol.org)
  • In 1971, Dr. Friend published another landmark paper, this one titled "Hemoglobin synthesis in murine virus-induced leukemic cells in vitro: Stimulation of erythroid differentiation by dimethyl sulfoxide. (mssm.edu)
  • This paper described research on leukemia cells that had been made to differentiate, or take another step in the maturation process to become erythroid cells, thus stopping their cancer-like multiplication. (mssm.edu)
  • It is not clear whether infection with this virus is a passenger of this condition (tired immune system with rapidly diving cells), or the causative agent of the disease and chronic activation. (virology.ws)
  • The acute erythroleukemia caused by the Friend virus is a multistage neoplasm suitable to study the sequence of oncogenic events involved in the progression of erythroblastic cells toward malignancy. (bloodjournal.org)
  • These antisera are of particular value in the analysis of the antigens of leukemia cells and of leukemia viruses because their mode of preparation precludes the formation of antibody against any normal constituents of the cell. (rupress.org)
  • In this first experiment, the biologists showed that they could get the Friend virus to adapt to and thus evade the MHC variants (b, d or k) in the mouse cells it attacked. (thefreedictionary.com)
  • Xenotropic viruses replicate or reproduce in cells other than those of the host species. (wikipedia.org)
  • These viruses recognize and enter cells of non-rodent species by means of the cell-surface xenotropic and polytropic murine leukemia virus receptor (XPR1). (wikipedia.org)
  • Using this model, we discovered that viruses can subvert the suppressive nature of regulatory T cells to evade immunological destruction by CD8+ T cells. (nih.gov)
  • A special focus of his work has been the study of establishment and maintenance of chronic infections and virus escape with a focus on regulatory T cells and T cell exhaustion. (nih.gov)
  • Distinct roles of NK cells in viral immunity during different phases of acute Friend retrovirus infection. (helmholtz-hzi.de)
  • Cells producing gibbon ape lymphoma virus of FeLV were grown in class III containment cabinets and transferred in sealed flasks to a class II laminar flow cabinet, where the assay was performed. (utmb.edu)
  • This micromethod not only conserved reagents but also minimized the numbers of moderate risk tumor virus infected cells handled at one time. (utmb.edu)
  • Cloyd, MW & Bigner, DD 1977, ' Contained indirect viable cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses ', Journal of Clinical Microbiology , vol. 5, no. 1, pp. 86-90. (utmb.edu)
  • The effects of Friend erythroleukemia cells on angiogenesis were studied in chick embryo chorioallantoic membrane assay and in human umbilical vein endothelial cells. (bvsalud.org)
  • In chorioallantoic membrane assay, the conditioned medium of Friend cells stimulated in vivo angiogenesis to an extent comparable to that observed with Prostaglandin El, used as positive control. (bvsalud.org)
  • Prostaglandin El added to conditioned medium of Friend cells did not further increase angiogenesis. (bvsalud.org)
  • Conditioned medium of Friend erythroleukemia cells also stimulated proliferation of human umbilical vein endothelial cells to an extent comparable to that observed with fetal bovine serum, used as positive control. (bvsalud.org)
  • These results seem to indicate that Friend erythroleukemia cells produce and secrete factors stimulating angiogenesis. (bvsalud.org)
  • Tumor-specific CD4+ T cells develop cytotoxic activity and eliminate virus-induced tumor cells in the absence of regulatory T cells. (nih.gov)
  • In the current research, we have used a murine retrovirus-induced tumor cell line of C57BL/6 mouse origin, namely FBL-3 cells, as a model to study basic mechanisms of immunological control and escape during tumor formation. (nih.gov)
  • This study shows that tumor-specific CD4(+) T cells are able to protect against virus-induced tumor cells. (nih.gov)
  • Bovine leukemia virus (BLV) is a deltaretrovirus infecting bovine B cells and causing enzootic bovine leucosis. (biomedcentral.com)
  • TEL‐induced oligomerization is shown to be essential for the constitutive activation of the protein kinase activity and mitogenic properties of TEL-platelet derived growth factor receptor β (PDGFRβ), a fusion oncoprotein characteristic of the leukemic cells of chronic myelomonocytic leukemia harboring a t(5;12) chromosomal translocation. (embopress.org)
  • An essential step in retrovirus infection is the binding of the virus to its receptor on a target cell. (rcsb.org)
  • The complexity of responses necessary for recovery from Friend virus infection has implications for both immunotherapies and vaccines. (pnas.org)
  • Integrated Friend murine leukemia virus copies were analyzed by the Southern blotting procedure in myeloblastic cell lines obtained after in vitro infection of long-term mouse bone marrow cultures. (archives-ouvertes.fr)
  • Constitutive envelope gene expression prevents infection by interfering with the binding of viruses which recognize the same receptor. (ucl.ac.uk)
  • Target cell heterogeneity in murine leukemia virus infection. (okstate.edu)
  • Fingerprint Dive into the research topics of 'Target cell heterogeneity in murine leukemia virus infection. (okstate.edu)
  • Zoonotic infection of Brazilian primate workers with New World simian foamy virus. (bireme.br)
  • We previously performed a serological and molecular survey to assess the prevalence of foamy virus infection in people who reported contact with NHPs with a resulting wound [10]. (deepdyve.com)
  • B Cell Requirement for Robust Regulatory T Cell Responses to Friend Retrovirus Infection. (nih.gov)
  • Effects of type I interferons on Friend retrovirus infection. (helmholtz-hzi.de)
  • Role of interleukin-4 (IL-4), IL-12, and gamma interferon in primary and vaccine-primed immune responses to Friend retrovirus infection. (helmholtz-hzi.de)
  • A major genetic locus affecting resistance to infection with murine le" by T Pincus, W P. Rowe et al. (jax.org)
  • A major genetic locus affecting resistance to infection with murine leukemia viruses. (jax.org)
  • and Lilly, F, "A major genetic locus affecting resistance to infection with murine leukemia viruses. (jax.org)
  • Panel B shows a Western Blot for CHOP/GADD153 protein expression levels in equivalent samples from cultured microglia with mock, Fr57E and FrCasE virus infection, with and without 1 μM thapsigargin treatment for 24 hours in culture. (biomedcentral.com)
  • The mouse retrovirus murine leukemia virus (MLV) has been linked to the development of spontaneous autoimmune disease. (virology.ws)
  • Through these changes, the virus is able to target the cell membrane and approach it for virus-cell membrane fusion. (embopress.org)
  • The TM moiety is involved in anchoring the envelope complex (SU and TM) to the target cell membrane, and is directly responsible for cell membrane fusion and virus entry. (allindianpatents.com)
  • Raltegravir also inhibits integration of MLV DNA into the murine genome. (virology.ws)
  • [8] MLVs belong to the virus family Retroviridae and the genus gammaretrovirus and have a single-stranded RNA genome that replicates through a DNA intermediate. (wikipedia.org)
  • Thus it may be regarded as a group-specific antigen of murine leukemia viruses, in contrast to the type-specific cellular antigens demonstrable by the cytotoxic test. (rupress.org)
  • The Friend virus (FV) is a strain of murine leukemia virus. (wikipedia.org)
  • After negative staining, the average outer dimensions measured over several experiments for the C-type avian viruses, avian myeloblastosis virus (AMV) and Rous sarcoma virus, Prague strain, were about 1370 and 1340 Å, respectively. (aacrjournals.org)
  • ß-Lapachona prolonga la sobrevida de ratones con leucemia inducida por el virus de Friend y de pollos con sarcoma inducido por el virus de Rous y recientemente ha demostrado inhibir la proliferación in vitro de varias líneas tumorales humanas. (bvsalud.org)
  • Superantigens of mouse mammary tumor virus. (springer.com)
  • Expression of mouse mammary tumor virus superantigen mRNA in the thymus correlates with kinetics of self-reactive T-cell loss. (springer.com)
  • Exhibits antiviral activity against HIV-1, simian immunodeficiency viruses (SIVs), mouse mammary tumor virus (MMTV) and friend murine leukemia virus (FrMLV) and may inhibit the mobility of LTR retrotransposons. (uniprot.org)
  • The avian viruses were similar in size to the B-type murine virus, mouse mammary tumor virus, which measured about 1290 Å. (aacrjournals.org)
  • and ( c ) 1200 to 1400 Å, for B-type viruses (mouse mammary tumor virus). (aacrjournals.org)
  • The former carries the membrane fusion activity, and in most viruses, the latter controls this activity, so that it is triggered at the correct virus entry site in the target cell. (pnas.org)
  • A few murine leukemia viruses (MuLVs) (e.g. (asm.org)
  • Antigen-induced murine B cell lymphomas. (elsevier.com)
  • Chattopadhyay SK, Cloyd MW, Linemeyer DL, Lander MR, Rands E, Lowy DR (1982) Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. (springer.com)
  • However, antibody responses also appear essential for resistance against certain viruses such as enterovirus ( 9 ) and rabies virus ( 10 ), and there are numerous examples of antibodies curing or preventing viral infections ( 11 - 17 ). (pnas.org)
  • Adult W/Fu rats inoculated repeatedly with these isogenic leukemias produce cytotoxic and precipitating antibodies. (rupress.org)
  • Four additional antigens associated with leukemias induced by wild-type Gross virus have been demonstrated by immunoprecipitation, but their relation to viral and cellular antigens has not been determined. (rupress.org)
  • Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. (psu.edu)
  • The results indicate that resolution of retroviral infections may require more complex immunological responses than have been found for most other viruses. (pnas.org)
  • Several fusion determinants have been previously identified in murine leukemia virus (MLV) envelopes, but their functional interrelationships as well as the processes involved in fusion activation upon retroviral receptor recognition remain unelucidated. (asm.org)
  • It was originally identified as a protein that provides a retroviral integration site for integration of FRIEND MURINE LEUKEMIA VIRUS. (harvard.edu)
  • Publications] Uenishi Hirohide: 'Overlapping epitopes of Friend murine leukemia virus gag-encoded leader sequence recogniged by single cytotexic T-Hmphaoyte clones' Immunology Letters. (nii.ac.jp)
  • However, despite all disadvantages, virus vectors have been used to establish strong antigen-specific immune suppression. (hindawi.com)
  • the same antigen can be demonstrated in ether-treated Gross virus, but not in intact virus. (rupress.org)
  • Therefore, the motor neurons which degenerate in these diseases do not appear to be infected by the virus and are most likely affected indirectly ( 43 , 49 , 50 , 52 , 55 ). (asm.org)
  • The engineering of virus vectors has allowed the development of gene vaccines for a wide range of infectious diseases and cancer. (hindawi.com)
  • Retrovirus, zoonosis, hemoglobin, simian foamy virus Human diseases of zoonotic origin are a major and increasing public health problem [1]. (deepdyve.com)
  • Currently, HIV-1 infects approximately 30 million people worldwide, whereas HTLV-1 infects at least 5-10 million people [2, 4], and both viruses are etiological agents of very severe diseases. (deepdyve.com)
  • In spite of the difficulties, the interest remains extremely high, because this plant holds great promise for the effective treatment of cancers such as leukemia, candida and other troublesome infections, debilitating diseases (including arthritis), as well as a host of other complaints. (healthfree.com)
  • FIM3 (Friend-Murine Leukemia Virus Integration Site 3 Homolog) is an Uncategorized gene. (genecards.org)
  • Specific major histocompatibility complex (MHC) class I and II alleles are necessary for recovery, as is a non-MHC gene, Rfv-3, which controls virus-specific antibody responses. (pnas.org)
  • It has been shown that the env gene of these viruses harbors the determinant of neurovirulence. (asm.org)
  • Optimizing virus-cell fusion by engineering the amphotropic envelope will be highly desirable for several gene transfer applications. (asm.org)
  • The present invention relates to infectious bovine rhinotracheitis viruses which fail to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene, vaccines against infectious bovine rhinotracheitis containing the same and methods for production and use of same. (google.com.au)
  • 1. An infectious bovine rhinotracheitis virus which fails to produce any functional thymidine kinase as a result of an insertion in the thymidine kinase gene. (google.com.au)
  • 3. The infectious bovine rhinotracheitis virus as claimed in claim 1, wherein said insertion is a foreign gene which is inserted in a manner such that it is not expressed by said virus. (google.com.au)
  • 5) propagating the resulting infectious bovine rhinotracheitis virus mutant of step (4) at a non-permissive temperature for a temperature-sensitive virus so as to select for and produce a temperature-resistant infectious bovine rhinotracheitis virus mutant which fails to produce any functional thymidine kinase as a result of an insertion in the IBRV tk gene. (google.com.au)
  • It is encoded by the defective env gene of the virus. (uniprot.org)
  • 13 Because of its recurrent alteration during Friend erythroleukemia, 1 , 7 , 8 mutation of the tumor suppressor gene p53 was a prime candidate for an oncogenic event cooperating with spi-1 overexpression to promote malignant progression. (bloodjournal.org)
  • In one example, the gag gene from Friend Leukemia Virus encodes an H-2D d -restricted CTL target on the leukemia cell line, FBL-3 [ 22 ]. (pubmedcentralcanada.ca)
  • 1991 ) Erythroleukemia induction by Friend murine leukemia virus: insertional activation of a new member of the ets gene family, Fli-1 , closely linked to c-ets-1 . (biologists.org)
  • Fitting, T. "Studies of the structure and biosynthesis of the membrane glycoproteins encoded by the Friend murine leukemia virus" (1981). (ohsu.edu)
  • It is generally agreed that the fusion process of enveloped viruses is initiated by conformational rearrangements of the viral envelope glycoproteins. (asm.org)
  • Thus, structural rearrangements of the influenza virus hemagglutinin are triggered by the acidic environment of the vesicles in which the virions have been endocytosed after their attachment to sialic acid residues harbored by cell surface glycoproteins ( 45 ). (asm.org)
  • The human lung adenocarcinoma cell line EKVX produces an infectious xenotropic murine leukemia virus. (greenmedinfo.com)
  • Xenotropic murine leukemia virus-related virus ( XMRV ) is a retrovirus which was first described in 2006 as an apparently novel human pathogen found in tissue samples from men with prostate cancer . (wikipedia.org)
  • XMRV is closely related to several known xenotropic mouse viruses. (wikipedia.org)
  • Human immunodeficiency virus type 1 (HIV-1) and human T-lymphotropic virus type 1 (HTLV-1) emerged from a simian reservoir through interspecies transmission from nonhuman primates (NHPs) infected with simian immunodeficiency virus and simian T-lymphotropic virus type 1, respectively [2, 3]. (deepdyve.com)
  • Arteriopathy in macaques infected with simian immunodeficiency virus. (naver.com)
  • It is relatively easy to raise effective immune responses against transgenes encoded in virus vectors. (hindawi.com)
  • There is an ever-growing list of different virus species that are being used as virus vectors. (hindawi.com)
  • Fusion determinants identified thus far in MLVs include (i) a fusion peptide located at the amino terminus of the TM subunit identified by sequence analogy to bona fide fusion peptides of other enveloped viruses ( 23 ) and (ii) several fusion-influencing determinants located at both the amino terminus of the SU subunit ( 4 ) and the carboxy terminus of the TM subunit ( 40 , 43 ). (asm.org)
  • In the murine leukemia viruses (MLVs), Gag is cleaved at three sites during maturation, resulting in the formation of four cleavage products, i.e. (pubmedcentralcanada.ca)
  • XMRV is a murine leukemia virus (MLV) that formed through the recombination of the genomes of two parent MLVs known as preXMRV-1 and preXMRV-2. (wikipedia.org)
  • The name XMRV was given because the discoverers of the virus initially thought that it was a novel potential human pathogen that was related to but distinct from MLVs. (wikipedia.org)
  • 2. The infectious bovine rhinotracheitis virus as claimed in claim 1, wherein said insertion is about 8 to 5000 bp in size. (google.com.au)
  • 4. The infectious bovine rhinotracheitis virus as claimed in claim 1, wherein said virus is also temperature-resistant. (google.com.au)
  • 5. The infectious bovine rhinotracheitis virus as claimed in claim 1, wherein said virus has the identifying characteristics of IBRV(βGalINV) (ATCC No. VR 2160). (google.com.au)
  • 10. The infectious bovine rhinotracheitis virus as claimed in claim 7, wherein the infectious DNA of step (3) is derived from a temperature-resistant infectious bovine rhinotracheitis virus such that the resulting mutant of step (4) is also temperature-resistant. (google.com.au)
  • Most ERVs are defective for production of infectious virus. (springer.com)
  • These ERVs affect retrovirus-induced disease in a number of ways, including manipulation of the immune response, inhibition or facilitation of entry or other steps of virus replication, or as participants in the generation of infectious pathogenic viruses. (springer.com)
  • Infectious agents, such as viruses, have evolved mechanisms and strategies to invade their hosts and to escape their immune response. (allindianpatents.com)
  • Below are the list of possible Friend virus susceptibility protein products. (mybiosource.com)
  • Thus, a potential CTL epitope present in the Friend virus sequence is not properly processed and presented because of a natural flanking aspartic acid that obliterates the correct C-terminal cleavage site. (jimmunol.org)
  • Alizon M, Wain-Hobson S, Montagnier L, Sonigo P (1986) Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. (springer.com)
  • The Search by Peptide allows users to locate complexes in the database using an epitope sequence, a specific protein, a specific virus, or a combination of these. (crosstope.com)
  • En algunas combinaciones de cerdo y primate el rechazo del injerto es iniciado por el reconocimiento de anticuerpos del receptor a los ant genos presentes en los vasos sangu neos del donador. (medigraphic.com)
  • The SU protein is responsible for the recognition and the binding to the cellular receptor for the virus. (allindianpatents.com)
  • This cleavage is essential for the Env incorporation into virus particles. (wikipedia.org)
  • Transfection of molecularly cloned Friend murine leukemia virus DNA yields a highly leukemogenic helper-independent type C virus. (semanticscholar.org)
  • The integrase inhibitor Raltegravir has been found to block the replication of murine leukemia virus, which is highly related to XMRV. (virology.ws)
  • Given the similarity between the genomes of MLV and XMRV it seems likely that the drug will inhibit the virus. (virology.ws)
  • [1] [2] Initial reports erroneously linked the virus to prostate cancer and later to chronic fatigue syndrome (CFS), leading to considerable interest in the scientific and patient communities, investigation of XMRV as a potential cause of multiple medical conditions, and public-health concerns about the safety of the donated blood supply . (wikipedia.org)
  • Concomitant studies of oncornavirus cores indicated a clear difference between avian and murine type viruses. (aacrjournals.org)
  • These results suggest that the 100-Å smaller value obtained for the outer dimension of avian viruses is due to the presence of a smaller core component. (aacrjournals.org)
  • dsDNA-RT viruses are the seventh group in the Baltimore virus classification . (wikipedia.org)
  • They are not considered DNA viruses (class I of Baltimore classification), but rather reverse transcribing viruses because they replicate through an RNA intermediate. (wikipedia.org)
  • He published a book in 2005 entitled Les Dix Plus Gros Mensonges sur le SIDA (Ten Lies About AIDS),[citation needed] in which he denies a connection between the HIV virus and AIDS, instead attributing the disease to lifestyle and environmental factors. (wikipedia.org)
  • More than a dozen MAbs are now licensed for clinical use for diverse indications, such as prophylaxis of respiratory syncytial virus disease in neonates, treatment of Crohn's disease, prevention of coronary artery closure after angioplasty, and therapy of refractory rheumatoid arthritis ( 65 ). (asm.org)
  • The mechanism by which the virus induces this disease is not known, but stimulation of innate immune responses by viral DNA might be involved. (virology.ws)
  • 1 The early step of the Friend disease is characterized by a deregulation of growth and differentiation of erythropoietin (Epo)-independent erythroblasts. (bloodjournal.org)
  • Friend disease - mouse leukemia caused by the Friend virus. (thefreedictionary.com)