AlloxanFree Radicals: Highly reactive molecules with an unsatisfied electron valence pair. Free radicals are produced in both normal and pathological processes. They are proven or suspected agents of tissue damage in a wide variety of circumstances including radiation, damage from environment chemicals, and aging. Natural and pharmacological prevention of free radical damage is being actively investigated.Free Radical Scavengers: Substances that influence the course of a chemical reaction by ready combination with free radicals. Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries.Ninhydrin: 2,2-Dihydroxy-1H-indene-1,3-(2H)-dione. Reagent toxic to skin and mucus membranes. It is used in chemical assay for peptide bonds, i.e., protein determinations and has radiosensitizing properties.Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.Diabetes Mellitus, Experimental: Diabetes mellitus induced experimentally by administration of various diabetogenic agents or by PANCREATECTOMY.Electron Spin Resonance Spectroscopy: A technique applicable to the wide variety of substances which exhibit paramagnetism because of the magnetic moments of unpaired electrons. The spectra are useful for detection and identification, for determination of electron structure, for study of interactions between molecules, and for measurement of nuclear spins and moments. (From McGraw-Hill Encyclopedia of Science and Technology, 7th edition) Electron nuclear double resonance (ENDOR) spectroscopy is a variant of the technique which can give enhanced resolution. Electron spin resonance analysis can now be used in vivo, including imaging applications such as MAGNETIC RESONANCE IMAGING.Antioxidants: Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.PicratesSuperoxide Dismutase: An oxidoreductase that catalyzes the reaction between superoxide anions and hydrogen to yield molecular oxygen and hydrogen peroxide. The enzyme protects the cell against dangerous levels of superoxide. EC 1.15.1.1.Oxidation-Reduction: A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471).Trigonella: A plant genus of the family FABACEAE.Plant Extracts: Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.Islets of Langerhans: Irregular microscopic structures consisting of cords of endocrine cells that are scattered throughout the PANCREAS among the exocrine acini. Each islet is surrounded by connective tissue fibers and penetrated by a network of capillaries. There are four major cell types. The most abundant beta cells (50-80%) secrete INSULIN. Alpha cells (5-20%) secrete GLUCAGON. PP cells (10-35%) secrete PANCREATIC POLYPEPTIDE. Delta cells (~5%) secrete SOMATOSTATIN.Hydroxides: Inorganic compounds that contain the OH- group.Lipid Peroxidation: Peroxidase catalyzed oxidation of lipids using hydrogen peroxide as an electron acceptor.Nitrogen Oxides: Inorganic oxides that contain nitrogen.Blood Glucose: Glucose in blood.Reactive Oxygen Species: Molecules or ions formed by the incomplete one-electron reduction of oxygen. These reactive oxygen intermediates include SINGLET OXYGEN; SUPEROXIDES; PEROXIDES; HYDROXYL RADICAL; and HYPOCHLOROUS ACID. They contribute to the microbicidal activity of PHAGOCYTES, regulation of signal transduction and gene expression, and the oxidative damage to NUCLEIC ACIDS; PROTEINS; and LIPIDS.Glycosuria: The appearance of an abnormally large amount of GLUCOSE in the urine, such as more than 500 mg/day in adults. It can be due to HYPERGLYCEMIA or genetic defects in renal reabsorption (RENAL GLYCOSURIA).Rats, Wistar: A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.Oxidative Stress: A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).Catalase: An oxidoreductase that catalyzes the conversion of HYDROGEN PEROXIDE to water and oxygen. It is present in many animal cells. A deficiency of this enzyme results in ACATALASIA.Streptozocin: An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals.Hydrogen Peroxide: A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.Spin Labels: Molecules which contain an atom or a group of atoms exhibiting an unpaired electron spin that can be detected by electron spin resonance spectroscopy and can be bonded to another molecule. (McGraw-Hill Dictionary of Chemical and Technical Terms, 4th ed)Xanthine Oxidase: An iron-molybdenum flavoprotein containing FLAVIN-ADENINE DINUCLEOTIDE that oxidizes hypoxanthine, some other purines and pterins, and aldehydes. Deficiency of the enzyme, an autosomal recessive trait, causes xanthinuria.Angiotensin II: An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.Insulin: A 51-amino acid pancreatic hormone that plays a major role in the regulation of glucose metabolism, directly by suppressing endogenous glucose production (GLYCOGENOLYSIS; GLUCONEOGENESIS) and indirectly by suppressing GLUCAGON secretion and LIPOLYSIS. Native insulin is a globular protein comprised of a zinc-coordinated hexamer. Each insulin monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds. Insulin is used as a drug to control insulin-dependent diabetes mellitus (DIABETES MELLITUS, TYPE 1).Islets of Langerhans Transplantation: The transference of pancreatic islets within an individual, between individuals of the same species, or between individuals of different species.Glucose: A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.Secretory Pathway: A series of sequential intracellular steps involved in the transport of proteins (such as hormones and enzymes) from the site of synthesis to outside the cell. The pathway involves membrane-bound compartments through which the newly synthesized proteins undergo POST-TRANSLATIONAL MODIFICATIONS, packaging, storage, or transportation to the PLASMA MEMBRANE for secretion.Insulin-Secreting Cells: A type of pancreatic cell representing about 50-80% of the islet cells. Beta cells secrete INSULIN.Truth Disclosure: Truthful revelation of information, specifically when the information disclosed is likely to be psychologically painful ("bad news") to the recipient (e.g., revelation to a patient or a patient's family of the patient's DIAGNOSIS or PROGNOSIS) or embarrassing to the teller (e.g., revelation of medical errors).Bread: Baked food product made of flour or meal that is moistened, kneaded, and sometimes fermented. A major food since prehistoric times, it has been made in various forms using a variety of ingredients and methods.Deception: The act of deceiving or the fact of being deceived.Triticum: A plant genus of the family POACEAE that is the source of EDIBLE GRAIN. A hybrid with rye (SECALE CEREALE) is called TRITICALE. The seed is ground into FLOUR and used to make BREAD, and is the source of WHEAT GERM AGGLUTININS.Food-Processing Industry: The productive enterprises concerned with food processing.Food, Fortified: Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)Food Handling: Any aspect of the operations in the preparation, processing, transport, storage, packaging, wrapping, exposure for sale, service, or delivery of food.Euphorbia: A large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil, surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.Euphorbiaceae: The spurge family of flowering plants, in the order Euphorbiales, contains some 7,500 species in 275 genera. The family consists of annual and perennial herbs and woody shrubs or trees.Aphrodisiacs: Chemical agents or odors that stimulate sexual desires. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Tribulus: A plant genus of the family ZYGOPHYLLACEAE. Members contain steroidal saponins. Ingestion by grazing animals causes PHOTOSENSITIVITY DISORDERS called geeldikkop (yellow thick head) in South Africa.Nootropic Agents: Drugs used to specifically facilitate learning or memory, particularly to prevent the cognitive deficits associated with dementias. These drugs act by a variety of mechanisms. While no potent nootropic drugs have yet been accepted for general use, several are being actively investigated.PyransOlea: A plant genus of the family Oleaceae. The olive fruit is the source of olive oil.Oleaceae: A plant family of the order Lamiales. The leaves are usually opposite and the flowers usually have four sepals, four petals, two stamens, and two fused carpels that form a single superior ovary.Plant Oils: Oils derived from plants or plant products.Phenylethyl Alcohol: An antimicrobial, antiseptic, and disinfectant that is used also as an aromatic essence and preservative in pharmaceutics and perfumery.Stevia: A plant genus of the family ASTERACEAE. Members contain stevioside and other sweet diterpene glycosides. The leaf is used for sweetening (SWEETENING AGENTS).China: A country spanning from central Asia to the Pacific Ocean.Buddhism: The teaching ascribed to Gautama Buddha (ca. 483 B.C.) holding that suffering is inherent in life and that one can escape it into nirvana by mental and moral self-purification. (Webster, 3d ed)Parakeets: Common name for one of five species of small PARROTS, containing long tails.Seals, Earless: The family Phocidae, suborder PINNIPEDIA, order CARNIVORA, comprising the true seals. They lack external ears and are unable to use their hind flippers to walk. It includes over 18 species including the harp seal, probably the best known seal species in the world.Malus: A plant genus in the family ROSACEAE, order Rosales, subclass Rosidae. It is best known as a source of the edible fruit (apple) and is cultivated in temperate climates worldwide.Sweetening Agents: Substances that sweeten food, beverages, medications, etc., such as sugar, saccharine or other low-calorie synthetic products. (From Random House Unabridged Dictionary, 2d ed)
The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. Studies suggests that ... Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)2C(OH)2. It is ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
"Transformation of barbituric acid into alloxan by hydroxyl radicals: interaction with melatonin and with other hydroxyl radical ... The free radicals generated by this process then engage in secondary reactions. For example, the hydroxyl is a powerful, non- ... The Fenton reaction has importance in biology because it involves the creation of free radicals by chemicals that are present ... Superoxide ions and transition metals act in a synergistic manner in the creation of free radical damage. Therefore, although ...
Free radical attack has been observed for pyrimidine and photochemical reactions have been observed for substituted pyrimidines ... Although pyrimidine derivatives such as uric acid and alloxan were known in the early 19th century, a laboratory synthesis of a ... Grimaux, E. (1879). "Synthèse des dérivés uriques de la série de l'alloxane" [Synthesis of urea derivatives of the alloxan ... and alloxan. It is also found in many synthetic compounds such as barbiturates and the HIV drug, zidovudine. ...
... has shown antioxidant activity via inhibition of lipid peroxidation and the reduction of free radicals, reactive ... Bartosíková, L (2007). "Examination of the antioxidative and antidiabetic effect of pomiferin in alloxan-induced diabetes ...
"Free Radical Biology and Medicine - Vitamins C and E: Beneficial effects from a mechanistic perspective". Free Radical Biology ... Later, in 1948, while conducting experiments on alloxan effects on rats, Gyorge and Rose noted rats receiving tocopherol ... As an antioxidant, vitamin E acts as a peroxyl radical scavenger, disabling the production of damaging free radicals in tissues ... This removes the free radical intermediates and prevents the oxidation reaction from continuing. The oxidized α-tocopheroxyl ...
"Free radical biology & medicine 43 (1): 4-15. PMC 2040110. PMID 17561088. doi:10.1016/j.freeradbiomed.2007.03.024.. ... cando estaban facendo experimentos sobre os efectos do alloxan en ratas, Gyorge e Rose notaron que as ratas que recibían ... Brigelius-Flohé (2009). "Vitamin E: the shrew waiting to be tamed". Free radical biology & medicine 46 (5): 543-54. PMID ... Azzi (2007). "Molecular mechanism of alpha-tocopherol action". Free radical biology & medicine 43 (1): 16-21. PMID 17561089. ...
1818: Brugnatelli isolates alloxan from uric acid. 1832: Dobereiner produces furfural (a furan) by treating starch with ... "Design and environmentally benign synthesis of novel thiophene appended pyrazole analogues as anti-inflammatory and radical ... From Wikipedia, the free encyclopedia. (Redirected from Heterocyclic ring). Jump to navigation Jump to search For other uses of ...
... of diabetes can be attributed to the unswerving harmful effect of free radicals on the enzyme or the diabetogenic agent alloxan ... Both SOD and catalase are major free radical-scavenging enzymes (Manonmani 2004). Their activities are usually little in ... Experimental diabetes was induced in 20 out of 25 male albino rats by intraperitoneal injection of 120 mg/kg b.w alloxan ... a Effect of methanolic extract of CAVCL on serum alanine transaminase concentration in alloxan-induced diabetic rats. b Effect ...
This study evaluated the effects of alloxan on the kinetics properties of the δ-aminolevulinate dehydratase (δ-ALA-D) using ... Elsner, M., Gurgul-Convey, E., & Lenzen, S. (2006). Free Radical Biology and Medicine, 41, 825-834.CrossRefGoogle Scholar ... The inhibition constant (K i ) for alloxan-induced inhibition on δ-ALA-D was 3.64 μM. The alloxan (5 μM) caused a decrease in V ... This study evaluated the effects of alloxan on the kinetics properties of the δ-aminolevulinate dehydratase (δ-ALA-D) using ...
Free radical modulation of insulin release in INS-1 cells exposed to alloxan. Biochem Pharmacol 1999;57:639-648pmid:10037448. ... Surgery was done in a specific pathogen-free environment, animals were anesthetized with Ketalar (65 mg/kg) and Xylasol (13 mg/ ... animals were housed singly in cages in a temperature-controlled room with a 12-h light/12-h dark cycle and were allowed free ...
Alloxan is a diabetogenic drug and is known to induce diabetes through generation of free radicals. The toxic oxygen species ... Cleavage may not arise directly from ascorbate free radical but the reaction of the radical form of ascorbate with oxygen may ... Erythrocytes exposed to alloxan induced lipid peroxidationin vivo as well asin vitro. Although alloxan treatment produced a ... Free radical mediated interaction of ascorbic acid and ascorbate/Cu(II) with viral and plasmid DNAs ...
... ethanol extract on alloxan-induced diabetic rats. Forty-eight albino rats (300 g) were used in this experiment... ... Jasna MC, Sonja MD, Gordana SC, Vesna TT (2004) Free-radical scavenging activity of wormwood (Artemisia absinthium) extracts. J ... Canadanovic BJ, Djilas SM, Cetkovic GS, Tumbas VT (2004) Free-radical scavenging activity of wormwood Artemisia absinthium ... Alloxan Diabetes A. absinthium Blood glucose Antihyperglycemic effect Biochemical markers This is a preview of subscription ...
Donnini D., Zambito A.M., Perrella G; Ambesi-Impiombato F.S., Curcio F. Glucose may induce cell death through a free radical- ... Blood glucose, glutathione, and total keto-acids levels in alloxan-diabetic rats. Zeitschrift für Ernährungswissenschaft 16(4 ... infection, inflammation and disease free for a very long time. Of course meditation, proper breathing, self hypnosis and ...
The beta cell toxic action of alloxan is initiated by free radicals formed in this redox reaction. Studies suggests that ... Alloxan, sometimes referred to as alloxan hydrate, refers to the organic compound with the formula OC(N(H)CO)2C(OH)2. It is ... The name "Alloxan" emerged from an amalgamation of the words "allantoin" and "Oxalsäure" (oxalic acid). The alloxan model of ... A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. Alloxan is a toxic ...
Now it comes out they have started using alloxan!. Alloxan is a poison, the most famous spinner up of super oxide free radicals ... because alloxan spins up enormous amounts of free radicals in pancreatic beta cells, utterly destroying them! ... Aspartame also so damages the mitochondria, that people are then damaged by the free radicals spun up by the damaged ... So, while I can verify that alloxan is bad juju, what I cant verify is that flour mills are using alloxan in their ...
Now it comes out they have started using alloxan!. Alloxan is a poison, the most famous spinner up of super oxide free radicals ... Now it comes out they have started using alloxan!. Alloxan is a poison, the most famous spinner up of super oxide free radicals ... because alloxan spins up enormous amounts of free radicals in pancreatic beta cells, utterly destroying them! ... because alloxan spins up enormous amounts of free radicals in pancreatic beta cells, utterly destroying them! ...
Antihyperglycemic effect of rambutan honey in alloxan-induced diabetic Wistar rats. J. Pharmacol. Toxicol., 12: 42-49.. ... Antioxidant Activity of Rambutan Honey: The Free Radical-Scavenging Activity in vitro and Lipid Peroxidation Inhibition of Oral ...
Aberrant elevation in levels of free radicals, as observed upon disease onset, and the subsequent reduction in anti-oxidant ... Therapeutic effect of vitamin B3 on hyperglycemia, oxidative stress and DNA damage in alloxan induced diabetic rat model.. ... This study reports the effects of niacin supplementation in alloxan induced diabetic rats divided into five groups. Diabetes ...
... pancreatic islets or dispersed islet cells from non-inbred ob/ob mice were performed to test the hypothesis that free radicals ... Alloxan-induced luminol luminescence as a tool for investigating mechanisms of radical-mediated diabetogenicity Biochem J ( ... Superoxide dismutase, catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic ... catalase and scavengers of hydroxyl radical protect against the toxic action of alloxan on pancreatic islet cells in vitro. ...
Erythrocytes from starved animals showed no alterations in the levels of major free radical-scavenging enzymes. However, GSSG ... Alterations in endogenous free radical-scavenging defense mechanisms of rat tissues after body weight loss (induced by ... The Protective Effect of Coenzyme Q 10 on Nephropathy in Alloxan-induced Diabetic Rats. *Miad Marashi, Sajjad Hejazi ... Alterations in endogenous free radical-scavenging defense mechanisms of rat tissues after body weight loss (induced by ...
Alloxan causes diabetes because it spins up enormous amounts of free radicals in pancreatic beta cells, thus destroying them. ... Hari Sharmas Freedom from Disease, alloxan causes free radical damage to DNA in the beta cells of the pancreas, causing them ... Alloxan in rats vs Alloxan in humans. Scientists have long known that alloxan produces selective destruction of the beta cells ... Alloxan is linked to diabetes. Alloxan, or C4 H2O4N2, is a product of the decomposition of uric acid. Its a poison thats used ...
... or read online for free. IOSR Journal of Pharmacy and Biological Sciences(IOSR-JPBS) is an open access international journal ... Free download as PDF File (.pdf), Text File (.txt) ... H. U. Nwanjo, Free radicals scavenging potential of the aqueous ... Alloxan-induced DNA trend breaks in pancreatic islets. Journal of Biological Chemistry, 266, 1991, 2112 2114. C. F. Eliakim- ... Leaf extracts in alloxan-induced diabetic rats. Iranian Journal of pharmacology and therapeutics, 4 (1), 2005, 38-39. ...
The selection of ALR, for resistance against alloxan-induced free radical-mediated diabetes, led to a strain of mice with an ... This mouse model with reduced ability to diffuse free radical stress is of obvious interest because free radical-mediated ... Commonalities of Genetic Resistance to Spontaneous Autoimmune and Free Radical--mediated Diabetes Free Radical Biology & ... Nov, 2008 , Pubmed ID: 18718526 ALR/Lt, a NOD-related mouse strain, was selected for resistance to alloxan free radical- ...
A single injection of alloxan monohydrate (120 mg/kg, i.p.) prepared in normal saline was administered to produce diabetes in ... estimation of free radicals like MDA and NO in plasma is relevant because the free radicals have been reported to delay wound ... This eventually leads to generation of free radicals resulting imbalance in the level of free radicals and antioxidants which ... Estimation of free radicals (MDA and NO levels). In contrast with the normal control group, diabetic wound significantly ...
The rapid uptake of alloxan and an exquisite sensitivity to free radicals (which alloxan produces en masse) are unique features ... 25). It is NADPH that ultimately allows neurons to repair the free radical damage created by the combination of their high ... The NADPH then combines with the oxidized glutathione (GSSG), regenerating it back to the free radical-quenching reduced ... Fasting blood sugar in the alloxan-but-no-GHB mice typically tripled at 48, 72 and 96 hours after alloxan treatment, compared ...
Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves ... Free Radical Biology & Medicine, 42, 1481-1486.. http://dx.doi.org/10.1016/j.freeradbiomed.2007.02.021 ... Diabetes was induced by alloxan at 180 mg/kg b.w by intra-peritoneal method once. Four weeks Oleuropein rich olive leaves ... Ghosh, S. and Surawanshi, S.A. (2001) Effect of Vinca rosea Extracts in Treatment of Alloxan Diabetes in Male Albina Rats. ...
Qi, X. Y., Chen, W. J., Zhang, L. Q., Xie, B. J. (2008). Mogrosides extract from Siraitia grosvenori scavenges free radicals in ... vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced diabetic mice. Nutr. Res. 28, 278-284. ...
Antioxidants are crucial in eliminating free radicals from your body. Free radicals are basically very reactive particles that ... Blood glucose, glutathione, and total keto-acids levels in alloxan-diabetic rats. Zeitschrift für Ernährungswissenschaft 16(4 ... Because free radicals are so destructive, cells have a network of defenses designed to neutralize them. This antioxidant ... Donnini D., Zambito A.M., Perrella G; Ambesi-Impiombato F.S., Curcio F. Glucose may induce cell death through a free radical- ...
The mechanism is thought to be initiated by the production of free radicals from reactive oxygen species (ROS) formed by ... Matsuzaki et al. [41] reported an inhibition of alloxan-induced disappearance of pancreatic β-cells in a group of 7-week-old ... Binding of free bile acids by cells of yogurt starter culture bacteria. J. Dairy Sci 2002, 85, 2705-2710. [Google Scholar] ... Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and β-cell ...
This actually makes plenty of sense, as multiple studies have highlighted the antioxidant [21] and free radical-scavenging [22] ... Effects of Mogroside Extract on Cellular Immune Function in Alloxan-Induced Diabetic Rats [26]. Acta Nutrimenta Sinica, 2006-03 ... Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and ... 34] Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, ...
Hyperglycemia in diabetes generates free radicals by mechanisms that are thought to involve metal-catalyzed oxidation of ... Specifically, alloxan-induced (10) and streptozotocin-induced (11-14) diabetic rats have been shown to increase glutathione ... It has been suggested that enzymes normally involved in detoxifying free radicals are partially incapacitated by nonenzymatic ... free radical neutralization, channels, pumps, lipid processing, transcription and translation machinery, protein trafficking, ...
Free Radical Scavenging Activity / Leaves : Study screened an ethanolic extract for in vitro antioxidant activity by various ... Antidiabetic / Toxicity Study: Study evaluated the hypoglycemic effects of P. minima extracts in alloxan-induced diabetic rats ... Free radical scavenging activity of Physalis minima Linn. leaf extract (PMLE) / C. Karpagasundari and S. Kulothungan / Journal ... Anti-Lipid Peroxidation: Study evaluated the free radical scavenging activity of ethanolic extracts of Piper trioicum and ...
  • Therefore, this work showed that the inhibition of hepatic δ-ALA-D activity can be obtained in vitro at low micromolar levels of alloxan, and can also be prevented by reducing agents. (springer.com)
  • Methoden om Beta Cell Death gemedieerd beoordelen door cytotoxische T lymfocyten Jing Chen 1 , Scott Grieshaber 1 , Clayton E. Mathews 1 1 Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida Cel-gemedieerde lymphocytotoxicity (CML) testen kunnen worden gebruikt voor het autoreactieve reacties en onderzoek naar mechanismen van celdood in vitro test. (jove.com)
  • Moreover, when alloxan make the injection on the islet cells in vitro by 60mg/kg dosage, after 30 Minutes it will be induce NF-kappaB. (fungus-extract.com)
  • In vitro and in vivo protective effect of Ganoderma lucidum polysaccharides on alloxan-induced pancreatic islets damage. (fungus-extract.com)
  • The main objective of this study was to investigate the in vitro antioxidant, free radical scavenging properties, and the protective effects of ethanol and aqueous ethanol extract from leaves and barks of A. lepidophyllus against oxidative mediated liver injuries. (beds.ac.uk)
  • Mogrosides extract from Siraitia grosvenori scavenges free radicals in vitro and lowers oxidative stress, serum glucose, and lipid levels in alloxan-induced amanda balionis weight loss mice. (waterfrontgibsons.com)
  • In addition, alloxan has a high affinity to SH-containing cellular compounds and, as a result, reduces glutathione content. (wikipedia.org)
  • But then the glutathione molecules are saturated with free radicals that need to be unloaded and sent back out empty enough to absorb more free radicals. (healthimpactnews.com)
  • GSSG topical cream formulations or by mouth with the over-the-counter oxidized form of L- Glutathione supplemental pills are what your would usually see on the open market in the health and drug stores) but essentially Glutathione protects your every cell in your body or at least it tries to and then breaks down into free Glutamate. (yourcprmd.com)
  • Alloxan reduced blood glucose level significantly within 60 min but thereafter a slow and steady rise was observed. (ias.ac.in)
  • Alloxan is a toxic glucose analogue, which selectively destroys insulin-producing cells in the pancreas (that is beta cells) when administered to rodents and many other animal species. (wikipedia.org)
  • Alloxan is selectively toxic to insulin-producing pancreatic beta cells because it preferentially accumulates in beta cells through uptake via the GLUT2 glucose transporter. (wikipedia.org)
  • Furthermore, alloxan inhibits glucokinase, a SH-containing protein essential for insulin secretion induced by glucose. (wikipedia.org)
  • Contrary to what people might claim, fresh, unprocessed monk fruit is not sugar free - figures vary between cultivar and growing region, but fresh monk fruit is typically one third carbohydrate, composed of a mix of fructose and glucose. (marksdailyapple.com)
  • Free radicals are formed disproportionately in diabetes by glucose oxidation, nonenzymatic glycation of proteins, and the subsequent oxidative degradation of glycated proteins. (jnsciences.org)
  • Treatment of animals with alloxan caused a significant increase (p≤0.05) in serum glucose concentration (49.47%) compared to normal control group. (sciencepublishinggroup.com)
  • Levi considers the droppings of pythons as a source for uric acid for making alloxan, but he is turned down by the director of the Turin zoo because the zoo already has lucrative contracts with pharmaceutical companies, so he is obliged to use chickens as his source of uric acid. (wikipedia.org)
  • Gaspard Brugnatelli) (1818) "Sur un acide nouveau obtenu en traitant l'acide urique par acide nitrique" (On a new acide obtained by treating uric acid with nitric acid), Annales de Chimie et de Physique, 2nd series, 8 : 201-204. (wikipedia.org)
  • Alloxan, or C4 H2O4N2, is a product of the decomposition of uric acid. (healthiertalk.com)
  • Flour it's self a beneficial food substance but during bleaching Alloxan, or C4 H2O4N2, is a product of the decomposition of uric acid which produces or added during the process makes flour unsuitable for our body. (vdcure.com)
  • Alterations in endogenous free radical-scavenging defense mechanisms of rat tissues after body weight loss (induced by starvation for 72 h) associated with hypoinsulinemia were investigated. (semanticscholar.org)
  • Oxidative and nitrosative stresses are situations characterized when the production of free radicals surpass the antioxidant defense levels, resulting in many peroxidative and nitrosative damaging reactions which in turn cause since DNA injury and mutations until cell death by necrosis or apoptosis . (oatext.com)
  • A dimeric derivative alloxantin can be prepared by partial reduction of alloxan with hydrogen sulfide. (wikipedia.org)
  • The aldehydes found to be inhibitory against P. falciparum could contribute to both the non-antibody host responses against this parasite and the antimalarial effects of radical-generating compounds such as t-butyl hydroperoxide, hydrogen peroxide, alloxan, isouramil, divicine and primaquine. (nih.gov)
  • Iron(III) is then reduced back to iron(II) by another molecule of hydrogen peroxide, forming a hydroperoxyl radical and a proton. (wikipedia.org)
  • The net effect is a disproportionation of hydrogen peroxide to create two different oxygen-radical species, with water (H+ + OH−) as a byproduct. (wikipedia.org)
  • 2018). Oxygen-free radicals induce a variety of lesions in DNA, including oxidized bases, abasic sites, DNA strand breaks and formation of cross-links between DNA and proteins ( Klages-Mundt et al. (bbrc.in)
  • 2018). Several drugs, xenobiotics and environmental pollutants are known to cause this imbalance between formation and removal of free radicals (Aguilar et al. (bbrc.in)
  • Chen C., Weng M., Wu C., Lin J. (2004): Comparison of radical scavenging activity, cytotoxic effects and apoptosis induction in human melanoma cells by Taiwanese propolis from different sources. (publicscienceframework.org)
  • These components were prepared in the form of a freeze-dried powder of the boiled leaf skin of Kidachi aloe, and measurement of 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging activity showed higher radical-scavenging activity in this boiled leaf skin powder than the non-boiled leaf skin powder. (fujita-hu.ac.jp)
  • In addition, the phenolic fraction of the Boiled leaf skin contained large amounts of 2′-O-p-coumaroylaloesin and 2′-O-feruloylaloesin, which have higher DPPH radical-scavenging activity than barbaloin. (fujita-hu.ac.jp)
  • Antioxidant capacity noticed that the reduction capacity of DPPH radicals obtained the best result comparatively to the others methods of free radical scavenging. (biomedcentral.com)
  • beta-Cells may be particularly vulnerable to alloxan because their metabolic specialization facilitates reduction of the drug and perhaps of other substrates for O2. (portlandpress.com)
  • Aerobic oxidation of ascorbate itself strictly requires transition metal catalysts, however electrochemically produced ascorbyl radical avoided the kinetic barrier that prevented direct oxidation of ascorbic acid with oxygen and eliminated the need for the transition metal ion catalysts. (ias.ac.in)
  • or singlet oxygen were added to the incubation medium and tested for their ability to protect against these effects of alloxan. (portlandpress.com)
  • Scientist's believe that about 5 to 15 grams of protein in 100 gram of wheat may be contaminated by alloxan, although no large scale studies have been done to know its effect on humans. (blogspot.in)