A glycolipid, cross-species antigen that induces production of antisheep hemolysin. It is present on the tissue cells of many species but absent in humans. It is found in many infectious agents.
Antigens stimulating the formation of, or combining with heterophile antibodies. They are cross-reacting antigens found in phylogenetically unrelated species.
Lipids containing at least one monosaccharide residue and either a sphingoid or a ceramide (CERAMIDES). They are subdivided into NEUTRAL GLYCOSPHINGOLIPIDS comprising monoglycosyl- and oligoglycosylsphingoids and monoglycosyl- and oligoglycosylceramides; and ACIDIC GLYCOSPHINGOLIPIDS which comprises sialosylglycosylsphingolipids (GANGLIOSIDES); SULFOGLYCOSPHINGOLIPIDS (formerly known as sulfatides), glycuronoglycosphingolipids, and phospho- and phosphonoglycosphingolipids. (From IUPAC's webpage)
Any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic moiety such as an acylglycerol (see GLYCERIDES), a sphingoid, a ceramide (CERAMIDES) (N-acylsphingoid) or a prenyl phosphate. (From IUPAC's webpage)

Forssman penta- and tetraglycosylceramide are xenoantigens of ostrich kidney and liver. (1/69)

The heterophile antigens Galalpha1-->3Gal and N-glycolylneuraminic acid are the major obstacle to grafting mammal organs, especially from pig, to man. Lack of expression of these common xenoantigens by birds has raised interest in ostrich as a potential organ donor for xenotransplantation. Glycosphingolipids of ostrich liver and kidney were investigated for their carbohydrate determinants. Both organs were found similar in their glycolipid composition with three major species, mono-, di-, and pentaglycosylceramide. The pentaglycosylceramide was characterized as the Forssman antigen. In both organs, the ceramide portion was highly hydroxylated with prevalence of alpha-hydroxylated fatty acids, C18 phytosphingosine in kidney and C18 sphingosine in liver Forssman glycolipid. These data indicate that hydroxylation of kidney glycosphingolipids, which is found in mammals, has been maintained since the divergence of birds from other vertebrates. Characterization of a minor glycolipid as a Forssman tetraglycosylceramide built on the galabiosylceramide core indicates that the Forssman tetraglycosylceramide also exists in vivo. Its precursors, galactosyl- and galabiosylceramide, were characterized in kidney and liver. The Forssman antigen is the third heterophile antigen against which man raises natural antibodies. Its localization in the vascular endothelium and connective tissue makes ostrich an unpromising organ or cell donor for xenotransplantation to man.  (+info)

Molecular modeling of glycosyltransferases involved in the biosynthesis of blood group A, blood group B, Forssman, and iGb3 antigens and their interaction with substrates. (2/69)

A terminal alpha1-3 linked Gal or GalNAc sugar residue is the common structure found in several oligosaccharide antigens, such as blood groups A and B, the xeno-antigen, the Forssman antigen, and the isogloboside 3 (iGb3) glycolipid. The enzymes involved in the addition of this residue display strong amino acid sequence similarities, suggesting a common fold. From a recently solved crystal structure of the bovine alpha3-galactosyltransferase complexed with UDP, homology modeling methods were used to build the four other enzymes of this family in their locked conformation. Nucleotide-sugars, the Mn2+ ion, and oligosaccharide acceptors were docked in the models. Nine different amino acid regions are involved in the substrate binding sites. After geometry optimization of the complexes and analysis of the predicted structures, the basis of the specificities can be rationalized. In the nucleotide-sugar binding site, the specificity between Gal or GalNAc transferase activity is due to the relative size of two clue amino acids. In the acceptor site, the presence of up to three tryptophan residues define the complexity of the oligosaccharide that can be specifically recognized. The modeling study helps in rationalizing the crystallographic data obtained in this family and provides insights on the basis of substrate and donor recognition.  (+info)

Inhibition of complement activation by recombinant Sh-CRIT-ed1 analogues. (3/69)

Sh-CRIT-ed1 is a potent anti-complement peptide that inhibits the classical complement-activation pathway by interfering with the formation of the C3-convertase complex, C4b2a. C2 is an essential serum glycoprotein that provides the catalytic subunit of the C3 and C5 convertases of the classical pathways of complement activation. Because only in its C4-bound state is C2a capable of cleaving its physiological protein substrates C3 and C5, the interaction of Sh-CRIT-ed1 with C2 plays a decisive role of inhibition in the classical complement-activation process. However, the role of individual Sh-CRIT-ed1 amino acid residues in C2 binding is not fully understood. We constructed nine recombinant Sh-CRIT-ed1 (rSh1) analogues, substituted at conserved residues, and evaluated their anti-complement and C2-binding activities. Results from glutathione S-transferase (GST) pull-down and haemolytic assays suggested that residues 10K, 17E, 19K and 26Y are critical for the interaction of rSh1 with C2. We then constructed an improved anti-complement peptide by duplicating Sh-CRIT-ed1 C-terminal motifs (17H-26Y). This linear homodimer (rH17d) was more potent than rSh1 with respect to binding to C2 and anti-complement activity (the 50% inhibitory concentration value was approximately equal 1.2 micro m versus approximately equal 6.02 micro m for rSh1). Furthermore, rH17d showed higher anti-complement activity in vivo, providing additional evidence that this duplication is a more effective inhibitor of complement activation than rSh1. Taken together, these results identify four key residues in rSh1 and strongly suggest that rH17d is a potent inhibitor of complement activation that may have therapeutic applications.  (+info)

Role of the pneumococcal autolysin (murein hydrolase) in the release of progeny bacteriophage and in the bacteriophage-induced lysis of the host cells. (4/69)

The pneumococcal bacteriophage Dp-1 seems to require the activity of the N-acetylmuramic acid-L-alanine amidase of the host bacterium for the liberation of phage progeny into the medium. This conclusion is based on a series of observations indicating that the exit of progeny phage particles is prevented by conditions that specifically inhibit the activity of the pneumococcal autolysin. These inhibitory conditions are as follows: (i) growth of the bacteria on ethanolamine-containing medium; (ii) growth of the cells at pH values that inhibit penicillin-induced lysis of pneumococcal cultures and lysis in the stationary phase of growth; (iii) addition of trypsin or the autolysin-inhibitory pneumococcal Forssman antigen (lipoteichoric acid) to the growth medium before lysis; (iv) infection of an autolysin-defective pneumococcal mutant at a multiplicity of infection less than 10 (treatment of such infected mutant bacteria with wild-type autolysin from without can liberate the entrapped progeny phage particles); (v) release of phage particles and culture lysis can also be inhibited by the addition of chloramphenicol to infected cultures just before the time at which lysis would normally occur. Bacteria infected with Dp-1 under conditions nonpermissive for culture lysis and phage release secrete into the growth medium a substantial portion of their cellular Forssman antigen in the form of a macromolecular complex that has autolysin-inhibitory activity. We suggest that a phage product may trigger the bacterial autolysin by a mechanism similar to that operating during treatment of pneumococci with penicillin (Tomasz and Waks, 1975).  (+info)

The 5T4 oncofoetal antigen is an early differentiation marker of mouse ES cells and its absence is a useful means to assess pluripotency. (5/69)

5T4 oncotrophoblast antigen is a transmembrane glycoprotein expressed by trophoblast and many carcinomas but not most normal adult tissues. Results from overexpression of human and mouse 5T4 cDNA in cell lines are consistent with it having an influence on adhesion, shape and motility. We show that murine embryonic stem cell lines are 5T4 negative but that there is rapid up regulation of protein and transcripts upon differentiation, including derivatives of each primary germ layer, as evidenced by cell surface FACS, western and RT-PCR analyses. The kinetics of differentiation and 5T4 expression are closely correlated, with early events linking 5T4 expression to changes in motility and morphology. Comparison of 5T4 expression with other ES cell transcript (Oct 3/4; Rex-1) and antigen markers (Forsmann, SSEA-1) establishes 5T4 as a useful marker for the non-destructive detection of early differentiation of ES cells. For example, 'undifferentiated' ES phenotype defined as SSEA-1 positive and 5T4 negative is seven times more efficient at chimera formation than SSEA-1-positive/5T4-positive cells. Thus, 5T4 glycoprotein expression is associated with early differentiative events of ES cells involving altered motility, and it has useful practical consequences for assessing ES potency and studying similar processes in development and metastasis.  (+info)

The parasitic trematode Fasciola hepatica exhibits mammalian-type glycolipids as well as Gal(beta1-6)Gal-terminating glycolipids that account for cestode serological cross-reactivity. (6/69)

Neutral glycosphingolipids from sheep-derived Fasciola hepatica liver flukes were isolated and characterized both structurally and serologically. After HPLC fractionation, glycolipids were analyzed by linkage analysis, enzymatic cleavage, and MALDI-TOF as well as electrospray ionization mass spectrometry. Obtained results revealed the presence of two types of neutral glycolipids. The first group represented mammalian-type species comprising globo- and isoglobotriaosylceramides (Gal(alpha1-4)Gal(beta1-4)Glc(1-1)ceramide and Gal(alpha1-3)Gal(beta1-4)Glc(1-1)ceramide, respectively) as well as Forssman antigen (GalNAc(alpha1-3)GalNAc(beta1-3/4)Gal(alpha1-4/3)Gal(beta1-4)Glc(1-1)ceramide). Applying Helix pomatia agglutinin, recognizing terminal alpha-linked GalNAc, to cryosections of adult flukes, the latter glycolipid could be localized to the F. hepatica gut. As Forssman antigen from the parasite and sheep host led to identical MALDI-TOF MS profiles, this glycolipid might be acquired from the definitive host. As a second group, highly antigenic glycolipids were structurally characterized as Gal(beta1-6)Gal(beta1-4)Glc(1-1)ceramide, Gal(beta1-6)Gal(alpha1-3/4)Gal(beta1-4)Glc(1-1)ceramide and Gal(beta1-6)Gal(beta1-6)Gal(alpha1-3/4)Gal(beta1-4)Glc(1-1)ceramide, the latter two structures of which exhibited both isoglobo- or globo-series core structures. Terminal Gal(beta1-6)Gal1-motifs have previously been shown to represent antigenic epitopes of neogala-series glycosphingolipids from tape worms. Using human Echinococcus granulosus infection sera, Gal(beta1-6)Gal-terminating glycolipids could be allocated to the gut in adult liver fluke cryosections. Corresponding neogala-reactive antibodies in F. hepatica infection serum were detected by their binding to E. granulosus and Taenia crassiceps neogala-glycosphingolipids. These antibodies might contribute to the known serological cross-reactivity between F. hepatica and parasitic cestode infections.  (+info)

Pharmacological studies on 6-amidino-2-naphthyl[4-(4,5-dihydro-1H-imidazol-2-yl)amino] benzoate dimethane sulfonate (FUT-187). I: Inhibitory activities on various kinds of enzymes in vitro and anticomplement activity in vivo. (7/69)

FUT-187, a newly synthesized compound, was studied on its inhibitory activities mainly on proteolytic enzymes, in comparison with those of FUT-175 and FOY-305, known serine protease inhibitors. FUT-187, as well as FUT-175 and FOY-305, had selective inhibitory activities on serine proteases including Clr, Cls, kallikrein, trypsin, plasmin and thrombin; its activities on these enzymes except Clr and pancreatic kallikrein were relatively lower than those of FUT-175 and FOY-305. Further studies were conducted focusing on complement-mediated reactions. In spite of its lower activities against Clr and Cls, inhibitions by FUT-187 on the complement-mediated hemolysis in vitro and in vivo were only a little weaker than or equivalent to that of FUT-175. FOY-305 was ineffective in these tests. Forssman shock in guinea pigs is known to be initiated by the activation of the complement system. The protective effect of intravenous or oral FUT-187 against this shock was definitely superior to that of FUT-175. Furthermore, FUT-187 inhibited changes accompanied with Forssman shock, such as increase in lung weight, the decrease in platelet counts and CH50, and histopathological changes. These results suggested that FUT-187 should be a more potent oral therapeutic agent than FUT-175 for various inflammatory diseases attributed to the excessive activation of the complement system followed by platelet aggregation.  (+info)

Long-term evolution of the CAZY glycosyltransferase 6 (ABO) gene family from fishes to mammals--a birth-and-death evolution model. (8/69)

Functional glycosyltransferase 6 (GT6) family members catalyze the transfer of galactose or N-acetylgalactosamine in alpha1,3 linkage to various substrates and synthesize structures related to the A and B histo-blood group antigens, the Forssman antigen, alphaGal epitope, and iGb3 glycolipid. In rat, mouse, dog, and cow genomes, we have identified three new mammalian genes (GT6m5, GT6m6, and GT6m7) encoding putative proteins belonging to the GT6 family. Among these, GT6m6 protein does not display major alterations of the GT6 motifs involved in binding of the divalent cation and the substrate. Based on protein sequence comparison, gene structure, and synteny, GT6 homologous sequences were also identified in bird, fish, and amphibian genomes. Strikingly, the number and type of GT6 genes varied widely from species to species, even within phylogenetically related groups. In human, except ABO functional alleles, all other GT6 genes are either absent or nonfunctional. Human, mouse, and cow have only one ABO gene, whereas rat and dog have several. In the chicken, the Forssman synthase-like is the single GT6 family member. Five Forssman synthase-like genes were found in zebrafish, but are absent from three other fishes (fugu, puffer fish, and medaka). Two iGb3 synthase-like genes were found in medaka, which are absent from zebrafish. Fugu, puffer fish, and medaka have an additional GT6 gene that we termed GT6m8, which is absent from all other species analyzed here. These observations indicate that individual GT6 genes have expanded and contracted by recurrent duplications and deletions during vertebrate evolution, following a birth-and-death evolution type.  (+info)

Looking for online definition of Forssman antigen in the Medical Dictionary? Forssman antigen explanation free. What is Forssman antigen? Meaning of Forssman antigen medical term. What does Forssman antigen mean?
TY - JOUR. T1 - Interaction of antibody with Forssman antigen in guinea pigs. T2 - A mechanism of adaptation to antibody- and complement-mediated injury. AU - Yuzawa, Y.. AU - Brett, J.. AU - Fukatsu, A.. AU - Matsuo, S.. AU - Caldwell, P. R.B.. AU - Niesen, N.. AU - Milgrom, F.. AU - Godman, G.. AU - Stern, D.. AU - Andres, G.. PY - 1995. Y1 - 1995. N2 - Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to blood group antigens and antigens that are the main barrier to xenogeneic organ transplantation. Herein, we describe the localization of Forssman antigen in guinea pig lungs and kidneys and the consequences of its interaction with antibodies in vitro and in vivo (Forssman reaction). Exposure of cultured guinea pig aortic endothelial cells to Forssman antibodies induced rapid redistribution of antigen-antibody complexes at the cell surface, followed by shedding that occurred by blebbing of plasma membrane as vesicles or ...
Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter jejuni and Pasteurella multocida
1. A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions. Wang YX, Xue DT, Liu M, Zhou ZM, Shang J. A novel arctigenin-containing latex glove prevents latex allergy by inhibiting type I/IV allergic reactions. Chinese Journal of Natural Medicines 2016; 14(3): 185-195. (doi:10.1016/S1875-5364(16)30015-2). Abstract. Wang and colleagues aimed at developing a natural compound with anti-allergic effect as well as stability under latex glove manufacturing conditions and investigated whether its anti-allergic effect could be maintained after its addition into the latex. The effects of nine natural compounds on growth of the RBL-2H3 cells and mouse primary spleen lymphocytes were determined using MTT assay. The compounds examined included glycyrrhizin, osthole, tetrandrine, tea polyphenol, catechin, arctigenin, oleanolic acid, baicalin and oxymatrine. An ELISA assay was used for the in vitro anti-type I/IV allergy screening; in this process ...
The receptors on type II pneumocytes and vascular endothelial cells responsible for attachment of pneumococci are of two types; both of them differ from the receptor on nasopharyngeal cells. Saccharides that can competitively inhibit the adherence of S. pneumoniae to pneumocytes and vascular endothelial cells help to define those receptors. They include mannose, GalNAc, Gal, the glycoconjugates asialo-GM1 and GM2, and the Gal NAcβ1-3 Gal-containing Forssman glycolipid (33). It should be mentioned here that the exposure of type II pneumocytes and vascular endothelial cells to the inflammatory cytokines TNFα and IL-1 significantly elevate the glycoconjugate receptors for pneumococci (33,42). L. , enterotoxigenic E. coli, Haemophilus influenzae, V. cholerae). Pathogens that penetrate epithelial barriers survive by invading and replicating in host cells. Tight junctions (zona occludens) that normally prevent penetration of epithelial cell layers also divide the epithelial cells into apical ...
Looking for online definition of CD49f antigen in the Medical Dictionary? CD49f antigen explanation free. What is CD49f antigen? Meaning of CD49f antigen medical term. What does CD49f antigen mean?
1LU1: Carbohydrate binding, quaternary structure and a novel hydrophobic binding site in two legume lectin oligomers from Dolichos biflorus.
The solution structures of three carbohydrate mimetics with gluco-, cellobio- and lacto-configurations from glycal dimerization are discussed. NOE experiments were used to establish the conformation across the glycosidic bond for both tetrasaccharide mimetics. J-resolved HMBC NMR experiments were used to measure long-range H,C coupling constants derived from iterative fitting of sin(pJHCt). The structures were found to be rigid with very little conformational averaging across the direct C-C-linkage.
Clone REA518 recognizes the human and mouse CD49f antigen, a 120 kDa single-pass type I membrane protein, which is also known as integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. Additional information: Clone REA518 displays negligible binding to Fc receptors. - Österreich
Its time, I want to see in glutathione actually works for skin lightening. I hear so many people saying it does but no documented progress from anyone who is originally NC45 or darker getting good even honest results. Either their videos are super washed out or they were born lighter. I spent 2k on liposomal glutathione and other vitamins. Yall know I am very specific about documenting so Ill be very honest with what Im using! So far my current tone is a result of caro white results and I
Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance):. ...
Looking for heterophile antibody test? Find out information about heterophile antibody test. heterophile agglutination test Explanation of heterophile antibody test
Although the CD4 molecule is the principal cellular receptor for the human immunodeficiency virus (HIV), several CD4-negative cell lines are susceptible to infection with one or more HIV strains. These findings indicate that there are alternate modes of viral entry, perhaps involving one or more receptor molecules. Antibodies against galactosyl ceramide (galactocerebroside, or GalC) inhibited viral internalization and infection in two CD4-negative cell lines derived from the nervous system: U373-MG and SK-N-MC. Furthermore, recombinant HIV surface glycoprotein gp120 bound to GalC but not to other glycolipids. These results suggest a role for GalC or a highly related molecule in HIV entry into neural cells. ...
The influenza virus is surrounded by an envelope composed of a lipid bilayer and integral membrane proteins. Understanding the structural dynamics of the membrane envelope provides biophysical insights into aspects of viral function, such as the wide-ranging survival times of the virion in different environments. We have combined experimental data from X-ray crystallography, nuclear magnetic resonance spectroscopy, cryo-electron microscopy, and lipidomics to build a model of the intact influenza A virion. This is the basis of microsecond-scale coarse-grained molecular dynamics simulations of the virion, providing simulations at different temperatures and with varying lipid compositions. The presence of the Forssman glycolipid alters a number of biophysical properties of the virion, resulting in reduced mobility of bilayer lipid and protein species. Reduced mobility in the virion membrane may confer physical robustness to changes in environmental conditions. Our simulations indicate that viral spike
The study of different strategies to improve the stability and bioavailability of bioactive components has increased in the last decades. One of the mechanisms that has acquired great relevance is to formulate using liposomal vesicles. Liposomes are structures that enhance the absorption, stability and transport of active compounds, which is reflected by an increase in the bioactivity of the encapsulated molecules. The guarana extract has proven to be rich in methylxanthines and phenolic compounds. These metabolites are associatedto a wide variety of pharmacological properties, and exert a stimulating effect. For this reason, it has become popular in nutritional products. In this workit was characterized physicochemically a nutritional product based on guarana, vitamins and folic acid. In this product the active components were encapsulated in liposomal vesicles, which were analyzed to know their structure, size (diameter) and membrane thickness. Results and analysis indicate that liposomes are ...
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is similar to the mouse stromal membrane-associated protein-1. This similarity suggests that this human gene product is also a type II membrane glycoprotein involved in the erythropoietic stimulatory activity of stromal cells. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008 ...
The QuickVue+ Mononucleosis Test detects IgM heterophile antibodies in acute phase infections using serum, plasma or whole blood.
Page 2 - Im not sure if this in the literature or not (probably) and I havent really studied it yet, but... If you have a 10kg kid with bronchospasm, what would you treatment be. Im imagining, that in
The sheep cell agglutination test or heterophile antibody reaction, as it is also called, is a laboratory procedure of considerable value in clinical medicine. In this country one frequently speaks alternately of the Paul-Bunnell test; and in Europe it is often referred to as the Hanganutziu-Deicher reaction. In 1911 Forssman1 recognized the nonspecificity of certain antigen-antibody reactions. The terms heterogenetic, heterophilic, or heterophile are applied to those antibodies that react with an antigen (sheep erythrocytes) which seemingly had nothing to do with their development. One type of heterophile antibody is known as the Forssman antibody, but there are other varieties ...
Synonyms for Antibodies, heterophile in Free Thesaurus. Antonyms for Antibodies, heterophile. 4 synonyms for infectious mononucleosis: glandular fever, kissing disease, mono, mononucleosis. What are synonyms for Antibodies, heterophile?
Heterophile definition is - of, relating to, or being an antibody circulating in blood serum that is reactive with antigen originating in a different species. How to use heterophile in a sentence.
In the tumor microenvironment, cytokines, growth factors, and oncogenes mediate constitutive activation from the signal transducer and activator of transcription 3 (STAT3) signaling pathway in both cancer cells and infiltrating immune cells. been shown to eliminate tumors through immune modulation. treatment of NSCLC with phenethyl isothiocyanate. For each of the studies reviewed, the formulation of phospholipids, the cholesterol content and the percentage of polyethylene glycol conjugated lipids differed. These differences can significantly impact treatment efficacy by affecting pharmacokinetics of ETP-46321 drug release and uptake profiles into phagocytic cells [22]. However, given the limited number of studies on liposomal delivery for each natural STAT3 inhibitor and the various cancer models that rarely match between studies, it was not possible to evaluate the effect of liposome compositions on drug efficacy. As more studies emerge on liposomal delivery of STAT3 inhibitors, hopefully the ...
Heterophile antibodies, in patients with infectious mononucleosis, may be present as early as the fourth day of illness, and by the twenty-first day of illness, 90% of patients will exhibit a positive test. The Epstein-Barr virus causes infectious mononucleosis.
HPLC Application #20098: Suprofen on Lux 5µm Cellulose-3 in NP. Column used: Lux® 5 µm Cellulose-3, LC Column 250 x 4.6 mm, Ea Part#: 00G-4493-E0
Results WT mice stromal cells display early acquisition of lymphoid features, up-regulating gp38 already at 3hours pc. Peak of this activation was observed at day5 with significant increase in the percentage of gp38+ lymphoid like stromal cells (LLSc), this increase is maintained between day8-15 pc. However, full acquisition of lymphoid phenotype, indicated by high levels of lymphoid CKs/cytokine expression was observed by day8-15 pc. This correlates with full maturation of the lymphoid aggregates in terms of T/B cell segregation and FDC formation. Of interest, RAG and LTbR KO mice showed normal degree of stromal cell activation in the early phases (2-5days p.c.) but a dramatic decrease in the percentage of LLSc by day15. However, these KOs exhibited a defect in full lymphoid conversion of stromal cells shown by significant decrease in CKs/cytokine expression and aggregates disorganization, suggesting that the full maturation of stromal cells require lymphocyte-derived signals such as ...
Supplemental Methods are available online with this article; doi:10.1172/JCI86489DS1.. Human leukemia samples and cell lines. All AML and T-ALL samples were collected from the Maisonneuve-Rosemont Hospital of Montreal, Canada. Human JURKAT, KOPTK1, P12-ICHIKAWA, and HPB-ALL cell lines were obtained from DSMZ, Germany.. Mice and ethics statement. All animals were maintained in pathogen-free conditions. The current study was performed using previously described SIL-SCL (referred to as SCLtg) and Lck-LMO1 (referred to as LMO1tg) mice (15, 16, 33). All mouse lines were backcrossed onto a C57BL6/J background for more than 12 generations. Mice cohorts were generated by cross-breeding, and their genotypes were verified by PCR.. Generation of MS5-DL4 stromal cell lines. Mouse stromal MS5 cells than can maintain in vitro both mouse and human long-term hematopoiesis were from K. Mori (Nagata University, Japan) (78) and were maintained as described previously (30). VSV-G-producing cells transfected with ...
Over 30 eating strategies - This information will be the cornerstone of your nutritional plans as you guide yourself and others to optimal wellness.. Delivery Systems of Nutrients - What different delivery options pose as beneficial or not so much. These sections on liposomal, sucrosomal and more delivery systems will aid you in finding the right supplement for yourself and others.. Chemist of Man- Body & Chemical Nutrients- the fundamental understanding of the interaction of micro and macro nutrients in an isolated or companion delivery method.. Collagen Peptide Therapy- Collagen peptides are highly bioavailable. They act as building blocks, renewing bodily tissues, such as skin, bones and joints. Discover the proper application and when therapeutic amounts are beneficial.. Water Quality- Water quality refers to the chemical, physical, biological, and radiological characteristics of water. Learn what waters are really wet and which ones are toxic to the body.. Air Quality- Discover the ...
J Swaminathan, C Ehrhardt, Effect of lyophilisation on liposomal systems for the delivery of salmon calcitonin (sCT), J Liposome Res, 24, 4, 2014, 297-303 ...
Stromal macrophages of different phenotypes can contribute to the expression of proteins that affects metastasis such as urokinase-type plasminogen activator (uPA), its receptor uPAR, and plasminogen activator inhibitor-1 (PAI-1), but knowledge of how essential their contribution is in comparison to the cancer cells in small cell lung cancer (SCLC) and lung squamous cell carcinoma (SCC) is lacking. The expression of uPA, uPAR, and PAI-1 and of the matrix metalloproteinases (MMP)-2 and MMP-9 were studied in human macrophages of M1 and M2 phenotype and compared to a lung SCC (NCI-H520) and a SCLC (NCI-H69) cell line. Effects of treatment with conditioned media (CM) from M1 and M2 macrophages on the expression of these genes in H520 and H69 cells as well as effects on the cell growth were investigated. In addition, data on the stromal macrophages immunoreactivity of uPAR, MMP-2, and MMP-9 in a few SCC and SCLC biopsies was included. uPAR, MMP-2, and MMP-9 were confirmed in stromal cells including ...
Component test codes cannot be used to order tests. The information provided here is not sufficient for interface builds; for a complete test mix, please click the sidebar link to access the Interface Map. ...
A fresh new look at an old technique in protein biochemistry has shown that it should be reintroduced to the spectroscopy toolkit.. For decades, scientists have used nuclear magnetic resonance (NMR) spectroscopy to probe the molecular motions of proteins on various timescales. This technique has revealed aspects of enzyme reactions, protein folding and other biological processes, all on an atomic scale.. Typically, spectroscopists will gauge the rotation of NMR-active atoms in the protein backbone with and without proton irradiation to calculate a ratio known as a steady-state nuclear Overhauser effect (NOE); however, it was not always done this way.. Before steady-state NOE experiments became the norm in biological investigations, scientists would often take a greater number of measurements over the course of an irradiation experiment. This method, termed dynamic NOE, might seem more complicated, but according to Ph.D. student Vladlena Kharchenko, it is no more time consuming than ...
As a result of our efforts to identify bioactive agents from marine algae, we have isolated and identified one new halogenated monoterpene 1 [(-)-(5E,7Z)-348-trichloro-7-dichloromethyl-3-methyl-157-octatriene] in addition to three known compounds (2, 3 and 4) from the red alga Plocamium cartilagineum collected by hand from the eastern coast of South Africa. Compound 1 was found to be active as a cytotoxic agent in human lung cancer (NCI-H460) and mouse neuro-2a cell lines (IC50 4 μg/mL). Two of these compounds (3 and 4) were found to have cytotoxic activity in other cell line assays, especially against human leukaemia and human colon cancers (IC50 1.3 μg/mL). None of these metabolites were active as sodium channel blockers or activators. All structures were determined by spectroscopic methods (UV, IR, LRMS, HRMS, 1D NMR and 2D NMR). 1D and 2D NOE experiments were carried out on these compounds to confirm the geometry of the double bonds.
Novel, optically active azido alcohols are synthesized from N-haloacetyl oxazolidinone and are coupled with protected, activated carbohydrate residues in stereoselective glycosidic fashion to provide glycolipids in substantially pure stereochemical form. In accordance with certain preferred embodiments, the glycosphingolipids globotriaosylceramide, lactosyl ceramide, and galactosyl ceramide are synthesized in substantially pure stereochemical form from alkenyl, C-18 azido alcohols and protected fluoroglycosides and are employed as antigens in the production of antibodies useful, for example, in the treatment of disease.
Hiai, H; Shisa, H; Nishizuka, Y; and Miyawaki, H, An antigen-binding cell tumor. Heterophile cold hemagglutinin as a membrane-bound receptor on a mouse lymphoma. (1974). Subject Strain Bibliography 1974. 975 ...
Clone REA1012 recognizes the human interleukin 17F (IL-17F) antigen, a homodimeric, 34 kDa member of the IL-17 family, which includes IL-17A, IL-17B, IL-17C, IL-17D, and IL-17E (also called IL-25). Interleukin 17 functions as a proinflammatory cytokine that responds to the invasion of the immune system by extracellular pathogens and induces destruction of the pathogens cellular matrix. Phylogenetic analysis reveals that among IL-17 family members, the IL-17F isoforms 1 and 2 (ML-1) have the highest homology to IL-17A (sharing 55 and 40% amino acid identity to IL-17A). IL-17F has been shown to have a pro-inflammatory role in asthma. It is expressed in the airway of asthmatics and its expression level is correlated with disease severity. IL-17F is able to induce several cytokines, chemokines and adhesion molecules in bronchial epithelial cells, vein endothelial cells, fibroblasts, and eosinophils. It is derived from several cell types such as T helper 17 (Tʜ17) cells, mast cells and basophils, and shows
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Tumour stromal macrophages differentiate to tumour-associated macrophages (TAMs) with characteristics of immunosuppressive M2-type macrophages, having a central role in promoting tumour vascularisation, cancer cell dissemination and in suppressing anti-cancer immune responses. Bisphosphonates (BPs) are a group of drugs commonly used as anti-resorptive agents. Further, nitrogen containing BPs like Zoledronate (ZOL), are known to cause unspecific inflammatory reactions hence the hypothesis that its use could modulate TAMs polarization toward a more inflammatory phenotype. We studied the in vitro polarization of J774 murine macrophages upon culture in 4T1 breast cancer cell-conditioned medium (4T1CM) and stimulation with LPS and free and liposome-encapsulated bisphosphonates. In this system, breast cancer soluble factors reduced the pro-inflammatory activation of macrophages but increased the secretion of matrix metalloproteinases (MMPs). In the presence of 4T1CM, a non-cytotoxic dose of liposome
Author(s): Milić N, Gađanski-Omerović Gordana, Ašanin Ružica, Nišavić J, Radojičić Marina. Keywords:PI3 virus, glycoprotein antigens, SDS-PAGE, BT cells, fusional test, hemolysis. The objective of our study was examination of the antigenic structure, fusional and hemolytic activities of the surface glycoprotein HN and F antigens of purified parainfluenza (PI 3) viruses activated with 0.025 g/dl trypsin-versen (molecular weights of 112 kD, 81-82 kD and 30-31 kD), in vitro. The samples of activated PI3 virions with total protein concentrations of 0.55 and 0.27mg/ml and hemagglutinating titre of 256 and 128 HAU/0.1 ml, induced bovine turbinate(BT) cell fusion and hemolysis of guinea-pig erythrocytes. After treatment of the aforementioned samples with specific hyperimmune sera against PI 3 virus in which the hemagglutination-inhibition (HI) titre was 1:64, cell fusion was not registered. The results show that there are possibilities to use fusional and hemolytic tests for the fast detection ...
Much of the work on liposomal drug delivery has focused on cancer treatment because conventionally delivered cancer chemotherapy has been far from satisfactory. Major problems with conventional chemotherapy are the inability of the drug to reach the tumor site at pharmacologically active concentrations, intrinsic as well as acquired cross-resistance to multiple chemotherapeutic agents, and toxicity that contributes to many of the treatment failures.. Doxorubicin encapsulated in long-circulating, PEGylated liposomes has proven to be more effective than the free drug in several tumor models, including murine tumors and human tumor xenografts, regardless of tumor type and site of implantation (27) . In all of the experiments conducted, the liposomal preparation clearly performed better than Free-Dox, and the peak tumor drug levels obtained by liposome delivery were at least 3-fold greater. Notable differences in toxicity between free drug and liposomal drug have also been observed, including ...
Clearview IM,For the qualitative detection of Infectious mononucleosis IgM heterophile antibodies in human whole blood, serum and plasma specimens.,medicine,medical supply,medical supplies,medical product
SureStep™ Mono Test,A rapid test for the visual, qualitative detection of heterophile antibodies specific to infectious mononucleosis in human serum, plasma or whole blood specimens. This test is intended as an aid in the diagnosis of infectious mononucleosis in patients with characteristic clinical symptoms.,medicine,medical supply,medical supplies,medical product
The conformational preorganization and anion-induced conformational changes of indole-based receptors functionalized with an amide group at the 2-position and a variety of amide, urea and thiourea moieties at the 7-position have been studied by the means of NMR spectroscopy. NOE experiments showed that anti-anti orientation across C2-C2 and C7-N7 bonds is preferred for receptors 1-4 in acetone solution in the absence of anions. Anion-receptor interactions have been evaluated through 1H and 15N chemical shift changes. In 2,7-bis-carboxamido functionalized indoles the interaction with chloride and bromide anions primarily occurs at the indole H1 proton. The introduction of urea and thiourea moieties increases the number of hydrogen bond donor sites which manifests itself in a distribution of halide-receptor interactions among the H1, H7 and H7 protons. Acetate anions also interact strongly with indole and urea NH donor groups, whereas nitrate anions interact solely with H7 and H7 urea/thiourea ...
Purpose: : Recent studies have identified a novel population of bone marrow-derived monocytic cells showing dynamic migratory and surveillance activity in the stroma. The purpose of this study was to further characterize the corneal monocytic cell population and determine whether monocytic/macrophages interact with corneal keratocytes. Methods: : Stromal cells were isolated from rabbit eyes by collagenase digestion and monocytic cells separated from keratocytes using magnetic bead separation with antibodies specific to rabbit CD45. CD45 cells were further characterized by flow cytometry using anti-rabbit specific antibodies to CD4, CD8, CD25, CD11c and CD11b. Isolated CD45 cells were then allowed to attach to plastic culture dishes to collect stromal macrophages and then stimulated with LPS, LTA and IL-1α at various concentrations. Serum-free keratocyte cultures were then exposed to stimulated, un-stimulated macrophages and conditioned media. Cells were then evaluated by western blotting, live ...
Container/Tube:. Preferred: Green-top (lithium heparin) tube. Acceptable: Gold-top serum gel tube or Plain Red-top tube. Specimen Volume: 170 uL of plasma or serum. Stability: Keep tubes stoppered and upright at all times. Do not use samples that have been stored at room temperature for longer than 8 hours. Tightly cap and refrigerate specimens at 2° to 8°C if the assay is not completed within 8 hours. Freeze samples at or below -20°C if the sample is not assayed within 48 hours. Freeze samples only once and mix thoroughly after thawing. Collection Instructions:. Note: 1. Human anti-mouse antibodies or other heterophile antibodies may be present in patient specimens. This assay has been specially formulated to minimize the effects of these antibodies, however results from patients known to have these antibodies should be carefully evaluated.. 2. Label specimen appropriately (plasma/serum).. ...
Heterophile abs. Abs in the samples against abs in the assay. Only way to remove is review your data and locate high false positives. Add into your sample buffer non-specific ab (IgG) of the species used as capture and detector in your system and check with the false positive. ,,use this buffer and pre-incubate the samples to bind up the heterophile ab,, Once the false positive is reduced or eliminated test a select few of your samples. Hopefully, the samples will line up according to the conentration you expect ...
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TY - JOUR. T1 - Accurate sampling of high-frequency motions in proteins by steady-state 15N-{ 1H} nuclear overhauser effect measurements in the presence of cross-correlated relaxation. AU - Ferrage, Fabien. AU - Cowburn, David. AU - Ghose, Ranajeet. N1 - Copyright: Copyright 2012 Elsevier B.V., All rights reserved.. PY - 2009/5/6. Y1 - 2009/5/6. N2 - The steady-state { 1H}- 15N NOE experiment is used in most common NMR analyses of backbone dynamics to accurately ascertain the effects of the fast dynamic modes. We demonstrate here that, in its most common implementation, this experiment generates an incorrect steady state in the presence of CSA/dipole cross-correlated relaxation leading to large errors in the characterization of these high-frequency modes. This affects both the quantitative and qualitative interpretation of 15N backbone relaxation in dynamic terms. We demonstrate further that minor changes in the experimental implementation effectively remove these errors and allow a more ...
A 40-year-old man with a past medical history of HIV presents to the clinic for follow-up. He reports that he has had difficulty swallowing, fevers and chills, nausea, vomiting, and abdominal pain. He reports that he has been compliant with his HIV medications. On physical exam, he has ulcers in his oropharynx. His laboratory tests reveal positive CMV-specific immunoglobulin G but negative heterophile antibodies. He is given an antiviral treatment and is admitted for an endoscopy workup and close monitoring. (CMV esophagitis) ...
Bronchospasms occur when you have an acute narrowing of your airways, making it difficult to breathe. Fast treatment will help reduce your symptoms.
In most cases of infectious mononucleosis, the clinical diagnosis can be made from the characteristic triad of fever, pharyngitis, and lymphadenopathy lasting for 1 to 4 weeks. Serologic test results include a normal to moderately elevated white blood cell count, an increased total number of lymphocytes, greater than 10% atypical lymphocytes, and a positive reaction to a mono spot test. In patients with symptoms compatible with infectious mononucleosis, a positive Paul-Bunnell heterophile antibody test result is diagnostic, and no further testing is necessary. Moderate-to-high levels of heterophile antibodies are seen during the first month of illness and decrease rapidly after week 4. False-positive results may be found in a small number of patients, and false-negative results may be obtained in 10% to 15% of patients, primarily in children younger than 10 years of age. True outbreaks of infectious mononucleosis are extremely rare. A substantial number of pseudo-outbreaks have been linked to ...
The virus is spread by intimate oral contact among adolescents, but how preadolescents acquire the virus is not known. During the incubation period of approximately 6 weeks, viral replication first occurs in the oropharynx followed by viremia as early as 2 weeks before onset of illness. The acute illness is marked by high viral loads in both the oral cavity and blood accompanied by the production of immunoglobulin M antibodies against EBV viral capsid antigen and an extraordinary expansion of CD8+ T lymphocytes directed against EBV-infected B cells. ,diet plan,healthy eating,healthy food,pregnancy tips,glucose tolerance test,diabetes test. During convalescence, CD8+ T cells return to normal levels and antibodies develop against EBV nuclear antigen-1. A typical clinical picture in an adolescent or young adult with a positive heterophile test is usually sufficient to make the diagnosis of infectious mononucleosis, but heterophile antibodies are not specific and do not develop in some patients ...
The effect of antigen dosage on the Forssman hemolysin response in rabbits. J. Infect. Dis., 113:155-69. 1964 With W. H. ... The hemolytic immunoglobulins produced by unirradiated and irradiated rabbits immunized with Forssman antigens. J. Infect. Dis ... Intercellular transfer of gamma A-1 and gamma A-2 Forssman hemolysins. Proc. Natl. Acad. Sci. USA, 47:713-24. 1962 With W. H. ... Effects of radiation on the initial and anamnestic IgM hemolysin responses in rabbits; antigen injection after X-rays. J. ...
... forssman antigen MeSH D23.050.285.018 - antigens, cd24 MeSH D23.050.285.025 - antigens, cd30 MeSH D23.050.285.040 - antigens, ... antigens, cd15 MeSH D23.101.100.900.131 - antigens, cd31 MeSH D23.101.100.920 - antigens, ly MeSH D23.101.100.930 - antigens, ... hla-a antigens MeSH D23.050.301.500.450.370.372 - hla-a1 antigen MeSH D23.050.301.500.450.370.374 - hla-a2 antigen MeSH D23.050 ... hla-b antigens MeSH D23.050.301.500.450.380.383 - hla-b7 antigen MeSH D23.050.301.500.450.380.385 - hla-b8 antigen MeSH D23.050 ...
Example: Forssman antigen, cross reacting microbial antigen so antibodies to these antigens produced by one species cross react ... Heterophile antigens are antigens of similar nature, if not identical, that are present in different tissues in different ... Usually different species have different antigen sets but the hetereophile antigen is shared by different species. Other ... Therefore antibodies are produced in rabbit serum by injecting the antigen (antiforssman antibodies). Taniguchi, T. (1921). " ...
CS1 maint: discouraged parameter (link) "Forssman antigen - definition of Forssman antigen in the Medical dictionary - by the ... The Forssman antigen is a glycolipid heterophil protein and a type of heterogenetic antigen found in certain animals like dogs ... The Forssman antigen is distinct from the Paul-Bunnell antigen, antibodies to which are diagnostic of glandular fever ( ... Both antigens are present on the red blood cells of horse and sheep but guinea pig kidney cells have only the Forssman antigen ...
He is known for discovery of the "Forssman antigen", defined as a glycolipid heterophile antigen found on tissue cells of many ... "Forssman reaction", also referred to as a "Forssman antigen-antibody reaction". Über die Ursachen, welche die ... Magnus John Karl August Forssman (22 November 1868 - 12 March 1947) was a Swedish pathologist and bacteriologist born in Kalmar ... His name is also associated with the following two terms: "Forssman antibody" (heterophile antibody) and " ...
Fc receptor Fc receptor-like molecule FcεRI Fibroblast-like synoviocyte FITkit FluoroSpot Forssman antigen Fragment antigen- ... opsonization Antibody-dependent cell-mediated cytotoxicity Antibody-dependent enhancement Antigen Antigen presentation Antigen ... DAMPs Danger model Defensin Degranulation Dendritic cell Dextran 1 Dispanin Dog leukocyte antigen Drug resistance Duffy antigen ... Herd immunity Heterophile Heterophile antigen Heterosubtypic immunity Histamine Histocompatibility Human leukocyte antigen ...
Ishibashi T, Kijimoto S, Makita A (1974). "Biosynthesis of globoside and Forssman hapten from trihexosylceramide and properties ... a synthase of human blood group P antigen, from canine spleen". J. Biol. Chem. 259 (9): 5637-42. PMID 6425294. Urano T, ...
It has been identified as a CD1d- presented self-antigen for an innate type of immune cells termed as Natural Killer T (NKT) ... Hansson GC, Karlsson KA, Larson G, McKibbin JM, Strömberg N, Thurin J. Isoglobotriaosylceramide and the Forssman glycolipid of ...
CS1 maint: discouraged parameter (link) "Forssman antigen - definition of Forssman antigen in the Medical dictionary - by the ... The Forssman antigen is a glycolipid heterophil protein and a type of heterogenetic antigen found in certain animals like dogs ... The Forssman antigen is distinct from the Paul-Bunnell antigen, antibodies to which are diagnostic of glandular fever ( ... Both antigens are present on the red blood cells of horse and sheep but guinea pig kidney cells have only the Forssman antigen ...
Forssman antigen explanation free. What is Forssman antigen? Meaning of Forssman antigen medical term. What does Forssman ... Looking for online definition of Forssman antigen in the Medical Dictionary? ... flagellar antigen H antigen.. Forssman antigen a heterogenetic antigen discovered in guinea pig tissues, capable of lysing ... Forssman antigen-antibody reaction - the combination of Forssman antibody with heterogenetic antigen of the Forssman type. ...
Forssman antigen-antibody reaction explanation free. What is Forssman antigen-antibody reaction? Meaning of Forssman antigen- ... Looking for online definition of Forssman antigen-antibody reaction in the Medical Dictionary? ... Forssman antigen-antibody reaction - the combination of Forssman antibody with heterogenetic antigen of the Forssman type. ... Forssman antigen-antibody reaction. Fors·sman an·ti·gen-an·ti·bod·y re·ac·tion. (fōrsmăn), the combination of Forssman ...
The results suggest that guinea-pig kidney extract positive for Forssman antigen alters the metabolism of S. mansoni adults in ... Abstract A total of 45 injections of guinea-pig kidney extract positive for Forssman antigen (0.1 mg nitrogen per injection) ... Effects of Guinea-Pig Kidney Extract Positive for Forssman Antigen on Adult Schistosoma Mansoni in Mice * * Kaye B. Cox†, José ... The results suggest that guinea-pig kidney extract positive for Forssman antigen alters the metabolism of S. mansoni adults in ...
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The expression of Forssman antigen on the surface of cells of post-implantation mouse embryos between 5 and 7 1/2 days old and ...
Definition of Forssman antibody. Provided by Stedmans medical dictionary and Drugs.com. Includes medical terms and definitions ... Definition: a heterogenetic antibody specific for the Forssman group of heterogenetic antigens. ...
Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter jejuni ... Campylobacter jejuni; Forssman antigen; glycosyltransferase; Pasteurella multocida. Abstract. We have identified an α1,4- ... [email protected]: Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter ... Complete chemoenzymatic synthesis of the Forssman antigen using novel glycosyltransferases identified in Campylobacter jejuni ...
N2 - Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to ... AB - Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to ... Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to ... Fingerprint Dive into the research topics of Interaction of antibody with Forssman antigen in guinea pigs: A mechanism of ...
a substance (usually injected with an antigen) that improves the immune response, either humoral or cellular, to the antigen ... heterophil antibody that is stimulated by one antigen and reacts with unrelated surface antigen present on cells from different ... point of dilution in a serologic reaction in which all the antigen and all the antibody are mutually involved in complexes ... a substance that can increase the specific antibody production to, or the degree of sensitization against antigen by increasing ...
Wolfe, B. A., and Robbins, P. W., 1974, Cell mitotic cycle synthesis of NIL hamster glycolipids including the Forssman antigen ... Amino sugar linkages of ceramide pentasaccharides of rabbit erythrocytes and of Forssman antigen. Arch. Biochem. Biophys. 155: ... Chemical modification of Forssman globoside and immunological activities, Jpn. J. Exp. Med. 45: 293-298.PubMedGoogle Scholar ... Esselman, W. J., and Miller, H. C., 1974a, The ganglioside nature of 0-antigen, Fed. Proc. Fed. Am. Soc. Exp. Biol. 33: 771. ...
Forssman Antigen. *Fucose (immunology, metabolism) *Glioblastoma (blood supply, metabolism) *Glucose (immunology, metabolism) ... D-GalNAc-beta1-R determinant of the Forssman pentasaccharide in tumors, the alpha-L-fucose in perivascular tumor areas, and the ...
The effect of antigen dosage on the Forssman hemolysin response in rabbits. J. Infect. Dis., 113:155-69. 1964 With W. H. ... The hemolytic immunoglobulins produced by unirradiated and irradiated rabbits immunized with Forssman antigens. J. Infect. Dis ... Intercellular transfer of gamma A-1 and gamma A-2 Forssman hemolysins. Proc. Natl. Acad. Sci. USA, 47:713-24. 1962 With W. H. ... Effects of radiation on the initial and anamnestic IgM hemolysin responses in rabbits; antigen injection after X-rays. J. ...
Pneumococcal Forssman antigen. A choline-containing lipoteichoic acid. J. Biol. Chem.248:6394-6397. ...
In 1911 Forssman1 recognized the nonspecificity of certain antigen-antibody reactions. The terms "heterogenetic," "heterophilic ... Enzyme-Linked Immunosorbent Assay of Antibodies to Epstein-Barr Virus Nuclear and Early Antigens in Patients with Infectious ... One type of heterophile antibody is known as the Forssman antibody, but there are other varieties ... or "heterophile" are applied to those antibodies that react with an antigen (sheep erythrocytes) which seemingly had nothing to ...
2857159 - Pneumococcal forssman antigen: enrichment in mesosomal membranes and specific binding t.... 11595219 - A rapid and ... 7119739 - Immunochemistry of the cell-surface carbohydrate antigens of clostridium difficile.. 25409529 - Nanofluidity of fatty ...
Characterization of Forssman and other antigen/antibody systems in vascularized mouse heart to rat xenotransplantation. ... evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b ...
Characterization of Forssman and other antigen/antibody systems in vascularized mouse heart to rat xenotransplantation. ... ABO-incompatible live donor renal transplantation using blood group A/B carbohydrate antigen immunoadsorption and anti-CD20 ...
The guinea pig kidney antigen absorbs (removes) Forssman heterophile antibodies while the beef red cell stroma removes ... The panel includes four antibody measurements: IgM viral capsid antigen (VCA), IgG VCA, Early Antigen (EA), and Epstein-Barr ... the serum is mixed with two different antigen suspensions, guinea pig kidney antigen and beef red blood cell stroma, prior to ... A rising or high IgG antibody titre to the viral capsid antigen and a negative antibody test to EBNA after at least four weeks ...
FORS blood group (Forssman antigen). K00722 GBGT1; globoside alpha-N-acetylgalactosaminyltransferase. Other DBs. RN: R05965 ... Forssman synthase;. globoside acetylgalactosaminyltransferase;. UDP-N-acetyl-D-galactosamine:N-acetyl-D-galactosaminyl-1,3-D- ... Biosynthesis of Forssman hapten from globoside by alpha-N-acetylgalactosaminyltransferase of guinea pig tissues. ... Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial ...
The CD45 antigen is common to all lines of leukocyte differentiation. Tested and found negative for ectromelia virus (mousepox ... The antibody reacts with an antigen, CD45, present on mouse lymph node and spleen cells but not on brain, kidney, liver or red ... Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma ... Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma ...
Two chapters are concerned with current topics in cellular immunology: the antigen receptor site and the cellular basis of ... In the essay, "Blood Group and Forssman Antigenic Determinants Shared Between Microbes and Mammalian ... and cross-reactivity between tissue and microbial antigens. ...
Aminosugar linkage of ceramide pentasaccharides of rabbit erythrocytes and of Forssman antigen," Archives of Biochemistry and ... G. Chen, H. Qian, T. Starzl et al., "Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal- ... Z. E. Holzknecht and J. L. Platt, "Identification of porcine endothelial cell membrane antigens recognized by human ... α-gal epitopes to antigen presenting cells (APC) [45-47]. Similarly, viral vaccines presenting α-gal epitopes and ...
Rott, R., Drzeniek, R., Saber, S., Reichert, E.: Blood group substances, Forssman and mononucleosis antigens in lipid- ... Isacson, P., Koch, A. E.: Association of host antigens with a parainfluenza virus. Virology 27, 129 (1965)PubMedCrossRefGoogle ... Kilbourne, E. D., Choppin, P. W., Schulze, I. T., Scholtissek, I. T., Bucher, D. L.: Influenza virus polypeptides and antigens ... Lee, L. T., Howe, C., Meyer, K., Cho, H. U.: Quantitative precipitin analysis of influenza virus host antigen and of sulfated ...
... human antibodies to the Forssman antigen (a glycolipid constituent of the influenza virion) [Nowinski et al., Science 210:537- ... The use of monoclonal antibodies to define protective antigens of microorganisms and to purify these antigens should aid in ... Murine monoclonal antibody to QKT3 antigen, a differentiation antigen expressed on all normal peripheral blood T lymphocytes, ... If the antigen is a protein, for example, an antigenic determinant may be one of the many peptide sequences [generally 6-7 ...
Siosteen, A., Steen, Y., Forssman, L. and Sullivan, L. (1993) Auto-Immunity to Spermatozoa and Quality of Semen in Men with ... Bohring, C., Krause, E., Habermann, B. and Krause, W. (2001) Isolation and Identification of sperm Membrane Antigens Recognized ... There are also publications suggesting that HLA-system antigens like HLA-B7 and HLA-BW35 alleles may be implicated in antisperm ... substantial heterogeneity in human sperm antigens, 2) the existence of different autoantibody classes (where IgA may be ...
... complex carbohydrate antigens, complex carbohydrates, A antigen, B antigen, H antigen, red blood cell antigens, A/B antigens, ... Blood Group Antigen Gene Mutation Database ,script type=text/javascript, var _gaq = _gaq ,, []; _gaq.push([_setAccount, UA ... ABH antigens, glycolipid, glycosphingolipids, glycoproteins, oligo sugars, red blood cells, RBC, blood transfusion, transfusion ... cell surface antigens, carbohydrate antigens, oligosaccharide antigens, oligosaccharides, ...
In fact, model B predicts repeating units with the minimal structure of Forssman antigens [GalNAc(α1→3)GalNAc(β1→] prior to ... Furthermore, the currently accepted structure does not explain the Forssman antigen properties of LTA and predicts a molecular ... which is the minimal structure for the Forssman antigen. Based on these data, we propose a revised model of LTA structure: its ... which is necessary to explain the Forssman antigen properties of pneumococcal LTA (3, 20). In addition, when we examined the ...
Nearly all individuals in our group had high antibody levels to Rha-α, Rha-β, and the Forssman disaccharide suggesting that ... In general, individuals had high antibody levels to many different carbohydrate antigens. The carbohydrate antigens with the ... when comparing antibody levels for many antigens including known tumor-associated carbohydrate antigens such as the Tn antigen ... Profiling human serum antibodies with a carbohydrate antigen microarray. Oyindasola Oyelaran,a Lisa M. McShane,b Lori Dodd,b ...
  • The Forssman antigen is distinct from the Paul-Bunnell antigen, antibodies to which are diagnostic of glandular fever (infectious mononucleosis). (wikipedia.org)
  • Herein, we describe the localization of Forssman antigen in guinea pig lungs and kidneys and the consequences of its interaction with antibodies in vitro and in vivo (Forssman reaction). (fujita-hu.ac.jp)
  • Exposure of cultured guinea pig aortic endothelial cells to Forssman antibodies induced rapid redistribution of antigen-antibody complexes at the cell surface, followed by shedding that occurred by blebbing of plasma membrane as vesicles or fragments, and was associated with disappearance of antigen from the cell surface (antigenic modulation). (fujita-hu.ac.jp)
  • Guinea pigs surviving frequent intravenous injections of increasing amounts of antibodies, for a total of 20 to 40 lethal doses, developed a partial or complete adaptation to generalized Forssman reaction, and adaptation was associated with partial or complete modulation of Forssman antigen at the surface of the pulmonary and, in minor degree, renal endothelial and epithelial cells. (fujita-hu.ac.jp)
  • The terms "heterogenetic," "heterophilic," or "heterophile" are applied to those antibodies that react with an antigen (sheep erythrocytes) which seemingly had nothing to do with their development. (annals.org)
  • Heterophile antibodies may be of two types, called Forssman and nonForssman. (encyclopedia.com)
  • Testing for heterophile antibodies must distinguish these from the Forssman type which are not produced by IM and are present in the blood of many persons without IM. (encyclopedia.com)
  • The guinea pig kidney antigen absorbs (removes) Forssman heterophile antibodies while the beef red cell stroma removes nonForssman IM antibodies. (encyclopedia.com)
  • Monoclonal xenogeneic antibodies to murine cell surface antigens: identification of novel leukocyte differentiation antigens. (atcc.org)
  • Monoclonal antibodies as probes for differentiation and tumor-associated antigens: a Forssman specificity on teratocarcinoma stem cells. (atcc.org)
  • The formation of fowl plague virus antigens in infected cells as studied with fluorescent antibodies. (springer.com)
  • A variety of high-throughput approaches, including SEREX, 1 phage display, 2 , 3 and peptide/protein arrays, 4 , 5 have been developed to identify disease specific antibodies to protein and peptide antigens from the repertoire of antibodies present in serum. (pubmedcentralcanada.ca)
  • Nussenzweig, Victor 1968-11-01 00:00:00 Sheep red blood cells sensitized by 7S, but not by 19S rabbit anti-Forssman antibodies, adhere and form rosettes on mouse macrophages and on a few monocytes and polymorphonuclear cells (PMN). (deepdyve.com)
  • EAC' prepared with 7S anti-Forssman antibodies has identical properties. (deepdyve.com)
  • The capsules are injected into an experimental animal where antigen passing through the pores of the capsule membrane induces lymphocytes to produce antibodies complementary to the antigen. (google.com)
  • Antigens stimulating the formation of, or combining with heterophile antibodies. (semanticscholar.org)
  • Antibodies elicited in a different species from which the antigen originated. (fpnotebook.com)
  • These antibodies are directed against a wide variety of interspecies-specific antigens, the best known of which are Forssman, Hanganutziu-Deicher (H-D), and Paul-Bunnell (P-B). Incidence of antibodies to these antigens--i.e., the phenomenon of heterophile antibody response--is useful in the serodiagnosis, pathogenesis, and prognosis of infection and latent infectious states as well as in cancer classification. (fpnotebook.com)
  • Therapeutic Monoclonal Antibodies to Complex Membrane Protein Targets: Antigen Generation and Antibody Discovery Strategies. (bioportfolio.com)
  • Epitopes are immunologically active regions of an immunogen that bind to antigen-specific membrane receptors on lymphocytes or to secreted antibodies. (microbeonline.com)
  • Each donor expressed many ACAs, but had a relatively unique ACAR, which included unanticipated antibodies to carbohydrate antigens not well studied, such as chitin oligosaccharides, Forssman-related antigens, globo-type antigens, and bacterial glycans. (elsevier.com)
  • We also saw some expected antibodies to ABO(H) blood group and α-Gal-type antigens, although these also varied among individuals. (elsevier.com)
  • The affinity-purified TF{alpha} antibodies showed only marginal cross-reactivity with the related antigens lactose, Gal, Tn or the Forssman antigen. (mdc-berlin.de)
  • Besides TF-specific antibodies, we found antibodies to the carbohydrate antigens Tn, Forssman and {beta}-D-Gal as well as to noncarbohydrate epitopes of glycophorin in human serum. (mdc-berlin.de)
  • Antibodies against mouse heart, erythrocytes and lymphocytes and against the Forssman antigen were raised in the rat. (termsreign.ml)
  • First, the original model was unable to explain the cross-reactivity of pnLTA with anti-Forssman antigen antibodies. (health-media.net)
  • Other non-Gal glycan determinants which humans may have occurring antibodies against include normally, but aren't limited by, Gal1,3GalNAc1-R (Thomsen-Friedenreich antigen), Sid bloodstream group (Sda)-like antigens, terminal -connected GalNAc, 3-connected Gal, sulfatide as well as the bloodstream group pk antigen [22]. (bioednet.org)
  • Interestingly, antibodies to other non-ABH glycans, such as the alpha-Gal antigen, also correlated with blood type. (studylib.ru)
  • The most well-known examples of anti-glycan antibodies are those that bind ABH blood group antigens and ones that bind xenoantigens such as the alpha-Gal antigen. (studylib.ru)
  • Detection of anti-glycan antibodies against blood group A and B antigens provides a simple and reliable strategy to predict which individuals are suitable matches for transfusions and transplants1-3. (studylib.ru)
  • Antigen exposure accounts only partially for variations among individuals in their repertoire of serum anti-glycan antibodies. (studylib.ru)
  • Anti-glycan antibodies can be produced to self or altered self-antigens and to antigens without known exposure. (studylib.ru)
  • The branch of biomedicine concerned with the structure and function of the immune system, innate and acquired immunity, the bodily distinction of self from nonself, and laboratory techniques involving the interaction of antigens with specific antibodies. (northamericanpharmacal.com)
  • Antibodies occur as antigen receptors on the surface of B cells and are secreted as soluble proteins when the B cells mature into plasma cells. (thefreedictionary.com)
  • By becoming attached to antigens on infectious organisms antibodies can render them harmless or cause them to be destroyed. (thefreedictionary.com)
  • Some antibodies destroy antigens directly. (healthmatics.info)
  • The repertoire of antiglycan antibodies of peripheral blood was studied using a microarray containing 487 glycan antigens: fragments of mammalian glycans (N- and O-chains of glycoproteins, as well as glycolipids) and also bacterial polysaccharides. (msu.ru)
  • It is generally accepted that foreign antigens cause the formation of antibodies that are known as adaptive, and their levels and affinities are directly related to the presence of these antigens. (msu.ru)
  • At the same time, extensive experimental material has accumulated about antibodies whose level and affinity for the antigen are practically constant throughout life [ 1 , 2 ]. (msu.ru)
  • Antigens can also react with formed antibodies. (thefreedictionary.com)
  • Microbial antigens prepared to induce protective antibodies are termed vaccines. (thefreedictionary.com)
  • These findings support the hypothesis that modulation of endothelial carbohydrate antigens contributes to adaptation of highly vascularized organs exposed to tolerable levels of allo- or xenoantibodies. (fujita-hu.ac.jp)
  • We also report antibody profiles for 48 human subjects and evaluate for the first time the effects of age, race, sex, geographic location, and blood type on antibody profiles for a large set of carbohydrate antigens. (pubmedcentralcanada.ca)
  • For this reason, most studies have been restricted to a small number of carbohydrate antigens that are readily available in large quantities. (pubmedcentralcanada.ca)
  • The glycan library included blood group antigens and some of the most frequently occurring terminal oligosaccharides, as well as core motifs of mammalian N- and O-linked glycoproteins and glycolipids, tumor-associated carbohydrate antigens, and bacterial polysaccharides mainly as a carbohydrate part of lipopolysaccharides. (msu.ru)
  • First, the serum is mixed with two different antigen suspensions, guinea pig kidney antigen and beef red blood cell stroma, prior to testing with the horse red cells. (encyclopedia.com)
  • In infectious mononucleosis, agglutination should be seen in the serum mixed with guinea pig antigen. (encyclopedia.com)
  • In this report, we describe the characterization of a carbohydrate antigen array and assay for profiling human serum. (pubmedcentralcanada.ca)
  • Finally, we conducted a longitudinal study with a separate group of 7 serum donors to evaluate the variation in anti-carbohydrate antibody levels within an individual over a period ranging from 3 to 13 weeks and found that, for nearly all antigens on our array, antibody levels are generally stable over this period. (pubmedcentralcanada.ca)
  • In basic and preclinical research, serum antibody profiling can facilitate the discovery of new antigens and guide vaccine design. (pubmedcentralcanada.ca)
  • When, however, C' factors from mouse serum are added to the antigen-19S antibody complex (EAC'), rosettes are formed on most mouse peritoneal macrophages and PMN and on a few monocytes. (deepdyve.com)
  • Has high affinity for the Forssman pentasaccharide. (abcam.com)
  • The genes encoding the three enzymes were cloned and expressed in Escherichia coli as soluble recombinant proteins that can be used to chemoenzymatically synthesize the Forssman antigen, and its biosynthetic precursors, in high yields. (gc.ca)
  • Namely, the A allele encodes A transferase, which transfers a GalNAc to the H antigen. (google.com)
  • Analysis of LTA fragments obtained after hydrofluoric acid and nitrous treatments showed that the fragments were consistent with an LTA nonreducing terminus consisting of GalNAc(α1→3)GalNAc(β1→, which is the minimal structure for the Forssman antigen. (asm.org)
  • Human blood type-A-hexasaccharide (GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-4Galβ1-4Glc) was found to exhibit the strongest ligand binding to the galectin while Forssman antigen (GalNAcα1-3GalNAcβ1-3Galα1- 4Galβ1-4Glc) and type-A-tetrasaccharide (GalNAcα1-3(Fucα1-2)Galβ1-4GlcNAcβ1-4Glc) were also extensively recognized. (eurekaselect.com)
  • It also showed high affinity to Forssman antigen which contains GalNAc α1-3 GalNAc structure, and to certain kinds of carbohydrate having a Gal α1-3 Gal structure. (nii.ac.jp)
  • Herein, NMR spectroscopy and molecular dynamics (MD) simulations were used to investigate the structural preferences of MGL against different GalNAc-containing structures derived from the blood groupâ A antigen, the Forssman antigen, and the GM2 glycolipid. (bvsalud.org)
  • However, key differences are observed in the recognition process depending on whether the GalNAc is part of the blood groupâ A antigen, the Forssman antigen, or GM2-derived structures. (bvsalud.org)
  • However, the expression of most sialytransferase mRNAs of Hanganutziu-Deicher antigen, sialy-Tn antigen, Forssman antigen, and Tn antigen was significantly down-regulated in the liver tissue of Cmah null mice. (nih.gov)
  • Summary: A new histo-blood group system was discovered, based on the identification of Forssman glycolipid antigen on human red blood cells. (kodecyte.com)
  • Sera from patients with Graves' disease and Hashimoto's thyroiditis have been shown to react with the Forssman glycolipid antigen (Gb5) using the techniques of high performance thin‐layer chromatography (HPTLC) immunostaining and ELISA. (elsevier.com)
  • Forssman antigen - the antibody that develops in infectious mononucleosis reacts specifically with the Forssman antigen. (thefreedictionary.com)
  • The antibody reacts with an antigen, CD45, present on mouse lymph node and spleen cells but not on brain, kidney, liver or red blood cells. (atcc.org)
  • We have also identified an α1,3-N-acetylgalactosaminyltransferase (Pm1138) from Pasteurella multocida Pm70, which is involved in the synthesis of an LOS-bound Forssman antigen mimic and represents the only known bacterial glycosyltransferase with this specificity. (gc.ca)
  • Forssman antigen is a glycosphingolipid with antigenic specificity determined by extra-membrane haptenic sugars similar to blood group antigens and antigens that are the main barrier to xenogeneic organ transplantation. (fujita-hu.ac.jp)
  • Intact E. coli cells which expressed the pH 6 antigen had a specificity similar to that of purified pH 6 in the TLC overlay assay except that nonhydroxylated galactosylceramide was also bound. (asm.org)
  • The recommended ELISA Kit will likely detect the antigen in question with higher specificity in approved samples than the available alternatives. (antibodies-online.com)
  • The Thomsen-Friedenreich (TF) disaccharide, galactose (Gal){beta}1- 3GalNAc{alpha}-, is a blood group-related oncofetal antigen with remarkable tumor specificity. (mdc-berlin.de)
  • class II a's major histocompatibility antigens found only on immunocompetent cells, primarily B lymphocytes and macrophages. (thefreedictionary.com)
  • Antigens that have not been exposed to immature lymphocytes during this critical period may be later recognized as nonself , or foreign , by the immune system. (microbeonline.com)
  • A type of protein made by B lymphocytes in response to a foreign substance (antigen). (healthmatics.info)
  • A protein made by plasma cells (a type of white blood cell) in response to an antigen (a substance that causes the body to make a specific immune response). (healthmatics.info)
  • 2. identical antigens in two bacterial strains, so that antibody produced against one strain will react with the other. (thefreedictionary.com)
  • Structurally, the pH 6 antigen was found to consist of PsaA, a subunit protein, which assembles to form homopolymeric fibrillar structures on the bacterial surface ( 6 , 7 ). (asm.org)
  • Y. pestis cells, E. coli cells expressing the pH 6 antigen, and crude potassium isothiocyanate extracts of bacterial cells expressing the pH 6 antigen were all found to agglutinate erythrocytes from a range of species ( 2 ). (asm.org)
  • The pH 6 antigen has been reported to bind to several human immunoglobulin G subclasses by acting as a bacterial Fc receptor ( 18 ). (asm.org)
  • Immunoglobulins produced in a response to BACTERIAL ANTIGENS. (healthmatics.info)
  • MSH immunoglobulins induced by exposure to bacterial antigens. (healthmatics.info)
  • In the case of infectious diseases , the antigens are components of invading microorganism's structure that are usually composed of proteins or polysaccharides. (microbeonline.com)
  • In sheep, it is found on erythrocytes but not on tissue and organs, unlike hamsters and guinea pigs whose organ cells do carry the antigen. (wikipedia.org)
  • Forssman antigen a heterogenetic antigen discovered in guinea pig tissues, capable of lysing sheep erythrocytes in the presence of complement. (thefreedictionary.com)
  • Blood-group antigens are generally defined as molecules formed by sequential addition of saccharides to the carbohydrate side chains of lipids and proteins detected on erythrocytes and certain epithelial cells. (abcam.cn)
  • Antigenic determinants, today often called epitopes, are sites on the surface of antigen molecules to which a single, specific antibody binds. (nih.gov)
  • The Forssman antigen is a glycolipid heterophil protein and a type of heterogenetic antigen found in certain animals like dogs, horses, cats, turtles and sheep, and enteric organisms such as pneumococci. (wikipedia.org)
  • Forssman antigen-antibody reaction - the combination of Forssman antibody with heterogenetic antigen of the Forssman type. (thefreedictionary.com)
  • 1. any of numerous protein molecules produced by B cells as a primary immune defense, each kind having a uniquely shaped site that combines with a foreign antigen, as of a virus or bacterium, and disables it. (thefreedictionary.com)
  • A protein produced in the blood or tissues in response to the presence of a specific foreign antigen. (thefreedictionary.com)
  • Three chapters deal with the subjects related to transplantation: the graft-versus-host reaction, immunologic enhancement, and cross-reactivity between tissue and microbial antigens. (annals.org)
  • The human immunodeficiency virus binds to this antigen and infects and kills T cells bearing this antigen, thus gradually destroying the body's ability to resist infection. (thefreedictionary.com)
  • each specific antibody binds only to the specific antigen that stimulated its production. (healthmatics.info)
  • Each antibody only binds to a specific antigen, helping to destroy the antigen directly or by assisting white blood cells to destroy the antigen. (healthmatics.info)
  • antigen-antibody reaction the reversible binding of antigen to homologous antibody by the formation of weak bonds between antigenic determinants on antigen molecules and antigen binding sites on immunoglobulin molecules. (thefreedictionary.com)
  • This report summarized his ongoing research into the polysaccharide antigens of pneumococcus and into cross reactions, the interaction of an antigen with an antibody formed against a different antigen with which the first antigen shares closely related determinants. (nih.gov)
  • Application of Two Dimensional NMR Methods to the Structural Elucidation of Complex Polysaccharide Antigens. (springer.com)
  • carcinoembryonic antigen (CEA) an oncofetal glycoprotein antigen originally thought to be specific for adenocarcinoma of the colon, but now known to be found in many other cancers and some nonmalignant conditions. (thefreedictionary.com)
  • Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS). (healthmatics.info)
  • 1. one that combines with antibody produced in response to a different but related antigen, owing to similarity of antigenic determinants. (thefreedictionary.com)
  • Both antigens are present on the red blood cells of horse and sheep but guinea pig kidney cells have only the Forssman antigen. (wikipedia.org)
  • Strains that carry these genes may have the capability of synthesizing mimics of the P blood group antigens of the globoseries glycolipids. (gc.ca)
  • Once the chemical structures defining the ABO blood system were determined, Watkins and Morgan, and separately Ceppellini, proposed a hypothesis on the biosynthetic pathway of these antigens. (google.com)
  • They postulated that A and B antigens are produced from the same precursor as an H antigen, which is abundant in individuals with blood group O. A and B antigens are formed by the action of glycosyltransferases encoded by functional alleles at the ABO genetic locus (The Central Dogma of ABO). (google.com)
  • This antibody recognizes human blood group A (monofucosyl and difucosyl A antigens with chain types 1, 2, 3, 4, 5, 6) and Forssman antigen. (abcam.cn)
  • Blood group related antigens represent a group of carbohydrate determinants carried on both glycolipids and glycoproteins. (abcam.cn)
  • As expected, IgG and IgM antibody signals to blood group antigens correlated strongly with blood type. (studylib.ru)
  • For example, antibody levels to blood group antigens can vary among healthy individuals with different blood types16. (studylib.ru)
  • Biochemistry) any of various proteins produced in the blood in response to the presence of an antigen. (thefreedictionary.com)
  • Others make it easier for white blood cells to destroy the antigen. (healthmatics.info)
  • With a few exceptions, such as the autoantigens and the isoantigens of the blood groups, antigens produce antibody only in species other than the ones from which they are derived. (thefreedictionary.com)
  • A hemolytic anti-LKE associated with a rare LKE-negative, "weak P" red blood cell phenotype: alloanti-LKE and alloanti-P recognize galactosylgloboside and monosialogalactosylgloboside (LKE) antigens. (uni-bielefeld.de)
  • Expression of Forssman antigen in the post-implantation mouse embryo. (wizdom.ai)
  • Expression of the pH 6 antigen, on the surface of the bacterium, is induced when the bacteria are grown between pH 5 and 6.7 and between 35 and 41°C ( 13 ). (asm.org)
  • glycolipids exposed many immunogenic carbohydrate determinants such as for example -Gal possibly, bloodstream OSI-906 group A, Neu5Gc and Forssman [20]. (bioednet.org)
  • Any of numerous Y-shaped glycoproteins that bind to specific antigens and either neutralize them or cause them to be destroyed by other elements of the immune system, such as phagocytes, cytotoxic cells, or complement proteins. (thefreedictionary.com)
  • Characterization of the human Forssman synthetase gene. (kegg.jp)
  • The pH 6 antigen structural gene ( psaA ) and a putative chaperone ( psaB ) are found within the cloned DNA fragment ( 6 ) and are expressed from the Y. pestis gene promoter ( 7 ). (asm.org)
  • A newly described polymorphism in the GBGT1 gene activates the encoded enzyme to synthesize Forssman antigen. (kodecyte.com)
  • antibody produced by the introduction of heterophile antigen into a species which does not carry it. (fpnotebook.com)
  • Cells such as genetically modified cells, e.g., hybridoma, which secrete an antigenic substance are encapsulated within capsule membranes having pores of dimensions sufficient to permit efflux of the antigens secreted by the cells but insufficient to permit traverse of the cells. (google.com)
  • A total of 45 injections of guinea-pig kidney extract positive for Forssman antigen (0.1 mg nitrogen per injection) was administered to mice 21 days before infection and until 65 days after infection by Puerto Rico strain Schistosoma mansoni cercariae. (ajtmh.org)
  • The results suggest that guinea-pig kidney extract positive for Forssman antigen alters the metabolism of S. mansoni adults in mice. (ajtmh.org)
  • 1,000 glycans, including antigens from animal cells and microbes, we profiled the IgG and IgM ACARs from all donors. (elsevier.com)
  • flagellar antigen H antigen . (thefreedictionary.com)
  • These may be proteins or polysaccharides derived from the outer surfaces of the cell (capsular antigens), from the cell interior (the somatic or O antigens), or from the flagella (the flagellar or H antigens). (thefreedictionary.com)
  • These results suggest that anti‐Forssman antibody may be involved in the pathogenesis of these autoimmune diseases. (elsevier.com)

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