AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Dosage FormsTabletsChemistry, PharmaceuticalExcipientsDelayed-Action PreparationsDrug CompoundingCapsulesTechnology, PharmaceuticalDrug StabilityPharmaceutical SolutionsSolubilityPharmaceutical PreparationsMethylcellulosePowdersDrug CarriersTherapeutic EquivalencyBiological AvailabilityAdministration, OralDrug Delivery SystemsEmulsionsSuspensionsOrnidazoleParticle SizeTablets, Enteric-CoatedPowder DiffractionChromatography, Reverse-PhaseChromatography, High Pressure LiquidDrug StoragePolymethacrylic AcidsCalibrationSpectrophotometry, UltravioletGene DosageLimit of DetectionReproducibility of ResultsDosage Compensation, GeneticSkin AbsorptionNanoparticlesAdministration, TopicalOxprenololPharmacokineticsDrug CombinationsKetoprofenCarboxymethylcellulose SodiumPolymersFreeze DryingPoloxamerCalorimetry, Differential ScanningBiopharmaceuticsHumidityPovidoneDothiepinThermogravimetryChitosanGelsHexuronic AcidsHardnessGlucuronic AcidHydrogen-Ion ConcentrationMicrospheresCellulosebeta-CyclodextrinsAdministration, CutaneousDrug Administration RoutesAmebicidesIbuprofenMicroscopy, Electron, ScanningAbsorptionGlipizidePolyvinylsPolyglycolic AcidSurface-Active AgentsAlginatesAdhesivenessHalf-LifeVeterinary DrugsArea Under CurveViscosityDiclofenacLoratadineTime FactorsTriacetinDrug ContaminationAmbroxolDrug Evaluation, PreclinicalChlorpheniramineIndicators and ReagentsSensitivity and SpecificityFamotidinePolyethylene GlycolsIntestinal AbsorptionQuality ControlDesiccationCross-Over StudiesLiposomesGelatinPharmaceutical VehiclesAcrylic ResinsReference StandardsSolventsWaterPorosityTemperatureHospital Bed Capacity, 500 and overCarbonatesKineticsAnti-Inflammatory Agents, Non-SteroidalSpectroscopy, Fourier Transform InfraredAcetaminophenDose-Response Relationship, DrugDiffusionModels, BiologicalFlow Injection AnalysisAlgorithmsDrug DesignLinear ModelsPharmacopoeias as TopicUnited States Food and Drug AdministrationMorphinansModels, ChemicalLactoseMethanolAnalgesics, Non-NarcoticMetoprololHydrochlorothiazideMolecular StructurePolysorbatesGastrointestinal TractAmlodipineX-Ray DiffractionPharmacistsAnti-Bacterial AgentsChromatography, Thin LayerSoftwareDogsTreatment OutcomeComputer SimulationEmulsifying AgentsNanostructuresOintmentsNanotechnology
Dosage Forms: Completed forms of the pharmaceutical preparation in which prescribed doses of medication are included. They are designed to resist action by gastric fluids, prevent vomiting and nausea, reduce or alleviate the undesirable taste and smells associated with oral administration, achieve a high concentration of drug at target site, or produce a delayed or long-acting drug effect.Tablets: Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)Chemistry, Pharmaceutical: Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.Excipients: Usually inert substances added to a prescription in order to provide suitable consistency to the dosage form. These include binders, matrix, base or diluent in pills, tablets, creams, salves, etc.Delayed-Action Preparations: Dosage forms of a drug that act over a period of time by controlled-release processes or technology.Drug Compounding: The preparation, mixing, and assembling of a drug. (From Remington, The Science and Practice of Pharmacy, 19th ed, p1814)Capsules: Hard or soft soluble containers used for the oral administration of medicine.Technology, Pharmaceutical: The application of scientific knowledge or technology to pharmacy and the pharmaceutical industry. It includes methods, techniques, and instrumentation in the manufacture, preparation, compounding, dispensing, packaging, and storing of drugs and other preparations used in diagnostic and determinative procedures, and in the treatment of patients.Drug Stability: The chemical and physical integrity of a pharmaceutical product.Pharmaceutical Solutions: Homogeneous liquid preparations that contain one or more chemical substances dissolved, i.e., molecularly dispersed, in a suitable solvent or mixture of mutually miscible solvents. For reasons of their ingredients, method of preparation, or use, they do not fall into another group of products.Solubility: The ability of a substance to be dissolved, i.e. to form a solution with another substance. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Pharmaceutical Preparations: Drugs intended for human or veterinary use, presented in their finished dosage form. Included here are materials used in the preparation and/or formulation of the finished dosage form.Methylcellulose: Methylester of cellulose. Methylcellulose is used as an emulsifying and suspending agent in cosmetics, pharmaceutics and the chemical industry. It is used therapeutically as a bulk laxative.Powders: Substances made up of an aggregation of small particles, as that obtained by grinding or trituration of a solid drug. In pharmacy it is a form in which substances are administered. (From Dorland, 28th ed)Drug Carriers: Forms to which substances are incorporated to improve the delivery and the effectiveness of drugs. Drug carriers are used in drug-delivery systems such as the controlled-release technology to prolong in vivo drug actions, decrease drug metabolism, and reduce drug toxicity. Carriers are also used in designs to increase the effectiveness of drug delivery to the target sites of pharmacological actions. Liposomes, albumin microspheres, soluble synthetic polymers, DNA complexes, protein-drug conjugates, and carrier erythrocytes among others have been employed as biodegradable drug carriers.Therapeutic Equivalency: The relative equivalency in the efficacy of different modes of treatment of a disease, most often used to compare the efficacy of different pharmaceuticals to treat a given disease.Biological Availability: The extent to which the active ingredient of a drug dosage form becomes available at the site of drug action or in a biological medium believed to reflect accessibility to a site of action.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Drug Delivery Systems: Systems for the delivery of drugs to target sites of pharmacological actions. Technologies employed include those concerning drug preparation, route of administration, site targeting, metabolism, and toxicity.Emulsions: Colloids formed by the combination of two immiscible liquids such as oil and water. Lipid-in-water emulsions are usually liquid, like milk or lotion. Water-in-lipid emulsions tend to be creams. The formation of emulsions may be aided by amphiphatic molecules that surround one component of the system to form MICELLES.Suspensions: Colloids with liquid continuous phase and solid dispersed phase; the term is used loosely also for solid-in-gas (AEROSOLS) and other colloidal systems; water-insoluble drugs may be given as suspensions.Ornidazole: A nitroimidazole antiprotozoal agent used in ameba and trichomonas infections. It is partially plasma-bound and also has radiation-sensitizing action.Particle Size: Relating to the size of solids.Tablets, Enteric-Coated: Tablets coated with material that delays release of the medication until after they leave the stomach. (Dorland, 28th ed)Powder Diffraction: Method of using a polycrystalline powder and Rietveld refinement (LEAST SQUARES ANALYSIS) of X-RAY DIFFRACTION or NEUTRON DIFFRACTION. It circumvents the difficulties of producing single large crystals.Chromatography, Reverse-Phase: A chromatography technique in which the stationary phase is composed of a non-polar substance with a polar mobile phase, in contrast to normal-phase chromatography in which the stationary phase is a polar substance with a non-polar mobile phase.Chromatography, High Pressure Liquid: Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.Drug Storage: The process of keeping pharmaceutical products in an appropriate location.Polymethacrylic Acids: Poly-2-methylpropenoic acids. Used in the manufacture of methacrylate resins and plastics in the form of pellets and granules, as absorbent for biological materials and as filters; also as biological membranes and as hydrogens. Synonyms: methylacrylate polymer; poly(methylacrylate); acrylic acid methyl ester polymer.Calibration: Determination, by measurement or comparison with a standard, of the correct value of each scale reading on a meter or other measuring instrument; or determination of the settings of a control device that correspond to particular values of voltage, current, frequency or other output.Spectrophotometry, Ultraviolet: Determination of the spectra of ultraviolet absorption by specific molecules in gases or liquids, for example Cl2, SO2, NO2, CS2, ozone, mercury vapor, and various unsaturated compounds. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Gene Dosage: The number of copies of a given gene present in the cell of an organism. An increase in gene dosage (by GENE DUPLICATION for example) can result in higher levels of gene product formation. GENE DOSAGE COMPENSATION mechanisms result in adjustments to the level GENE EXPRESSION when there are changes or differences in gene dosage.Limit of Detection: Concentration or quantity that is derived from the smallest measure that can be detected with reasonable certainty for a given analytical procedure.Reproducibility of Results: The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.Dosage Compensation, Genetic: Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.Skin Absorption: Uptake of substances through the SKIN.Nanoparticles: Nanometer-sized particles that are nanoscale in three dimensions. They include nanocrystaline materials; NANOCAPSULES; METAL NANOPARTICLES; DENDRIMERS, and QUANTUM DOTS. The uses of nanoparticles include DRUG DELIVERY SYSTEMS and cancer targeting and imaging.Administration, Topical: The application of drug preparations to the surfaces of the body, especially the skin (ADMINISTRATION, CUTANEOUS) or mucous membranes. This method of treatment is used to avoid systemic side effects when high doses are required at a localized area or as an alternative systemic administration route, to avoid hepatic processing for example.Oxprenolol: A beta-adrenergic antagonist used in the treatment of hypertension, angina pectoris, arrhythmias, and anxiety.Pharmacokinetics: Dynamic and kinetic mechanisms of exogenous chemical and DRUG LIBERATION; ABSORPTION; BIOLOGICAL TRANSPORT; TISSUE DISTRIBUTION; BIOTRANSFORMATION; elimination; and DRUG TOXICITY as a function of dosage, and rate of METABOLISM. LADMER, ADME and ADMET are abbreviations for liberation, absorption, distribution, metabolism, elimination, and toxicology.Drug Combinations: Single preparations containing two or more active agents, for the purpose of their concurrent administration as a fixed dose mixture.Ketoprofen: An IBUPROFEN-type anti-inflammatory analgesic and antipyretic. It is used in the treatment of rheumatoid arthritis and osteoarthritis.Carboxymethylcellulose Sodium: A cellulose derivative which is a beta-(1,4)-D-glucopyranose polymer. It is used as a bulk laxative and as an emulsifier and thickener in cosmetics and pharmaceuticals and as a stabilizer for reagents.Polymers: Compounds formed by the joining of smaller, usually repeating, units linked by covalent bonds. These compounds often form large macromolecules (e.g., BIOPOLYMERS; PLASTICS).Freeze Drying: Method of tissue preparation in which the tissue specimen is frozen and then dehydrated at low temperature in a high vacuum. This method is also used for dehydrating pharmaceutical and food products.Poloxamer: A nonionic polyoxyethylene-polyoxypropylene block co-polymer with the general formula HO(C2H4O)a(-C3H6O)b(C2H4O)aH. It is available in different grades which vary from liquids to solids. It is used as an emulsifying agent, solubilizing agent, surfactant, and wetting agent for antibiotics. Poloxamer is also used in ointment and suppository bases and as a tablet binder or coater. (Martindale The Extra Pharmacopoeia, 31st ed)Calorimetry, Differential Scanning: Differential thermal analysis in which the sample compartment of the apparatus is a differential calorimeter, allowing an exact measure of the heat of transition independent of the specific heat, thermal conductivity, and other variables of the sample.Biopharmaceutics: The study of the physical and chemical properties of a drug and its dosage form as related to the onset, duration, and intensity of its action.Humidity: A measure of the amount of WATER VAPOR in the air.Povidone: A polyvinyl polymer of variable molecular weight; used as suspending and dispersing agent and vehicle for pharmaceuticals; also used as blood volume expander.Dothiepin: A tricyclic antidepressant with some tranquilizing action.Thermogravimetry: Technique whereby the weight of a sample can be followed over a period of time while its temperature is being changed (usually increased at a constant rate).Chitosan: Deacetylated CHITIN, a linear polysaccharide of deacetylated beta-1,4-D-glucosamine. It is used in HYDROGEL and to treat WOUNDS.Gels: Colloids with a solid continuous phase and liquid as the dispersed phase; gels may be unstable when, due to temperature or other cause, the solid phase liquefies; the resulting colloid is called a sol.Hexuronic Acids: Term used to designate tetrahydroxy aldehydic acids obtained by oxidation of hexose sugars, i.e. glucuronic acid, galacturonic acid, etc. Historically, the name hexuronic acid was originally given to ascorbic acid.Hardness: The mechanical property of material that determines its resistance to force. HARDNESS TESTS measure this property.Glucuronic Acid: A sugar acid formed by the oxidation of the C-6 carbon of GLUCOSE. In addition to being a key intermediate metabolite of the uronic acid pathway, glucuronic acid also plays a role in the detoxification of certain drugs and toxins by conjugating with them to form GLUCURONIDES.Hydrogen-Ion Concentration: The normality of a solution with respect to HYDROGEN ions; H+. It is related to acidity measurements in most cases by pH = log 1/2[1/(H+)], where (H+) is the hydrogen ion concentration in gram equivalents per liter of solution. (McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Microspheres: Small uniformly-sized spherical particles, of micrometer dimensions, frequently labeled with radioisotopes or various reagents acting as tags or markers.Cellulose: A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.beta-Cyclodextrins: Cyclic GLUCANS consisting of seven (7) glucopyranose units linked by 1,4-glycosidic bonds.Administration, Cutaneous: The application of suitable drug dosage forms to the skin for either local or systemic effects.Drug Administration Routes: The various ways of administering a drug or other chemical to a site in a patient or animal from where the chemical is absorbed into the blood and delivered to the target tissue.Amebicides: Agents which are destructive to amebae, especially the parasitic species causing AMEBIASIS in man and animal.Ibuprofen: A nonsteroidal anti-inflammatory agent with analgesic properties used in the therapy of rheumatism and arthritis.Microscopy, Electron, Scanning: Microscopy in which the object is examined directly by an electron beam scanning the specimen point-by-point. The image is constructed by detecting the products of specimen interactions that are projected above the plane of the sample, such as backscattered electrons. Although SCANNING TRANSMISSION ELECTRON MICROSCOPY also scans the specimen point by point with the electron beam, the image is constructed by detecting the electrons, or their interaction products that are transmitted through the sample plane, so that is a form of TRANSMISSION ELECTRON MICROSCOPY.Absorption: The physical or physiological processes by which substances, tissue, cells, etc. take up or take in other substances or energy.Glipizide: An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.PolyvinylsPolyglycolic Acid: A biocompatible polymer used as a surgical suture material.Surface-Active Agents: Agents that modify interfacial tension of water; usually substances that have one lipophilic and one hydrophilic group in the molecule; includes soaps, detergents, emulsifiers, dispersing and wetting agents, and several groups of antiseptics.Alginates: Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.Adhesiveness: A property of the surface of an object that makes it stick to another surface.Half-Life: The time it takes for a substance (drug, radioactive nuclide, or other) to lose half of its pharmacologic, physiologic, or radiologic activity.Veterinary Drugs: Drugs used by veterinarians in the treatment of animal diseases. The veterinarian's pharmacological armamentarium is the counterpart of drugs treating human diseases, with dosage and administration adjusted to the size, weight, disease, and idiosyncrasies of the species. In the United States most drugs are subject to federal regulations with special reference to the safety of drugs and residues in edible animal products.Area Under Curve: A statistical means of summarizing information from a series of measurements on one individual. It is frequently used in clinical pharmacology where the AUC from serum levels can be interpreted as the total uptake of whatever has been administered. As a plot of the concentration of a drug against time, after a single dose of medicine, producing a standard shape curve, it is a means of comparing the bioavailability of the same drug made by different companies. (From Winslade, Dictionary of Clinical Research, 1992)Viscosity: The resistance that a gaseous or liquid system offers to flow when it is subjected to shear stress. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 6th ed)Diclofenac: A non-steroidal anti-inflammatory agent (NSAID) with antipyretic and analgesic actions. It is primarily available as the sodium salt.Loratadine: A second-generation histamine H1 receptor antagonist used in the treatment of allergic rhinitis and urticaria. Unlike most classical antihistamines (HISTAMINE H1 ANTAGONISTS) it lacks central nervous system depressing effects such as drowsiness.Time Factors: Elements of limited time intervals, contributing to particular results or situations.Triacetin: A triglyceride that is used as an antifungal agent.Drug Contamination: The presence of organisms, or any foreign material that makes a drug preparation impure.Ambroxol: A metabolite of BROMHEXINE that stimulates mucociliary action and clears the air passages in the respiratory tract. It is usually administered as the hydrochloride.Drug Evaluation, Preclinical: Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.Chlorpheniramine: A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than PROMETHAZINE.Indicators and Reagents: Substances used for the detection, identification, analysis, etc. of chemical, biological, or pathologic processes or conditions. Indicators are substances that change in physical appearance, e.g., color, at or approaching the endpoint of a chemical titration, e.g., on the passage between acidity and alkalinity. Reagents are substances used for the detection or determination of another substance by chemical or microscopical means, especially analysis. Types of reagents are precipitants, solvents, oxidizers, reducers, fluxes, and colorimetric reagents. (From Grant & Hackh's Chemical Dictionary, 5th ed, p301, p499)Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)Famotidine: A competitive histamine H2-receptor antagonist. Its main pharmacodynamic effect is the inhibition of gastric secretion.Polyethylene Glycols: Polymers of ETHYLENE OXIDE and water, and their ethers. They vary in consistency from liquid to solid depending on the molecular weight indicated by a number following the name. They are used as SURFACTANTS, dispersing agents, solvents, ointment and suppository bases, vehicles, and tablet excipients. Some specific groups are NONOXYNOLS, OCTOXYNOLS, and POLOXAMERS.Intestinal Absorption: Uptake of substances through the lining of the INTESTINES.Quality Control: A system for verifying and maintaining a desired level of quality in a product or process by careful planning, use of proper equipment, continued inspection, and corrective action as required. (Random House Unabridged Dictionary, 2d ed)Desiccation: Removal of moisture from a substance (chemical, food, tissue, etc.).Cross-Over Studies: Studies comparing two or more treatments or interventions in which the subjects or patients, upon completion of the course of one treatment, are switched to another. In the case of two treatments, A and B, half the subjects are randomly allocated to receive these in the order A, B and half to receive them in the order B, A. A criticism of this design is that effects of the first treatment may carry over into the period when the second is given. (Last, A Dictionary of Epidemiology, 2d ed)Liposomes: Artificial, single or multilaminar vesicles (made from lecithins or other lipids) that are used for the delivery of a variety of biological molecules or molecular complexes to cells, for example, drug delivery and gene transfer. They are also used to study membranes and membrane proteins.Gelatin: A product formed from skin, white connective tissue, or bone COLLAGEN. It is used as a protein food adjuvant, plasma substitute, hemostatic, suspending agent in pharmaceutical preparations, and in the manufacturing of capsules and suppositories.Pharmaceutical Vehicles: A carrier or inert medium used as a solvent (or diluent) in which the medicinally active agent is formulated and or administered. (Dictionary of Pharmacy, 1986)Acrylic ResinsReference Standards: A basis of value established for the measure of quantity, weight, extent or quality, e.g. weight standards, standard solutions, methods, techniques, and procedures used in diagnosis and therapy.Solvents: Liquids that dissolve other substances (solutes), generally solids, without any change in chemical composition, as, water containing sugar. (Grant & Hackh's Chemical Dictionary, 5th ed)Water: A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Porosity: Condition of having pores or open spaces. This often refers to bones, bone implants, or bone cements, but can refer to the porous state of any solid substance.Temperature: The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.Hospital Bed Capacity, 500 and overCarbonates: Salts or ions of the theoretical carbonic acid, containing the radical CO2(3-). Carbonates are readily decomposed by acids. The carbonates of the alkali metals are water-soluble; all others are insoluble. (From Grant & Hackh's Chemical Dictionary, 5th ed)Kinetics: The rate dynamics in chemical or physical systems.Anti-Inflammatory Agents, Non-Steroidal: Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions.They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.Spectroscopy, Fourier Transform Infrared: A spectroscopic technique in which a range of wavelengths is presented simultaneously with an interferometer and the spectrum is mathematically derived from the pattern thus obtained.Acetaminophen: Analgesic antipyretic derivative of acetanilide. It has weak anti-inflammatory properties and is used as a common analgesic, but may cause liver, blood cell, and kidney damage.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Diffusion: The tendency of a gas or solute to pass from a point of higher pressure or concentration to a point of lower pressure or concentration and to distribute itself throughout the available space. Diffusion, especially FACILITATED DIFFUSION, is a major mechanism of BIOLOGICAL TRANSPORT.Models, Biological: Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.Flow Injection Analysis: The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.Algorithms: A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.Drug Design: The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.Linear Models: Statistical models in which the value of a parameter for a given value of a factor is assumed to be equal to a + bx, where a and b are constants. The models predict a linear regression.Pharmacopoeias as Topic: Authoritative treatises on drugs and preparations, their description, formulation, analytic composition, physical constants, main chemical properties used in identification, standards for strength, purity, and dosage, chemical tests for determining identity and purity, etc. They are usually published under governmental jurisdiction (e.g., USP, the United States Pharmacopoeia; BP, British Pharmacopoeia; P. Helv., the Swiss Pharmacopoeia). They differ from FORMULARIES in that they are far more complete: formularies tend to be mere listings of formulas and prescriptions.United States Food and Drug Administration: An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.Morphinans: Compounds based on a partially saturated iminoethanophenanthrene, which can be described as ethylimino-bridged benzo-decahydronaphthalenes. They include some of the OPIOIDS found in PAPAVER that are used as ANALGESICS.Models, Chemical: Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment.Lactose: A disaccharide of GLUCOSE and GALACTOSE in human and cow milk. It is used in pharmacy for tablets, in medicine as a nutrient, and in industry.Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.Analgesics, Non-Narcotic: A subclass of analgesic agents that typically do not bind to OPIOID RECEPTORS and are not addictive. Many non-narcotic analgesics are offered as NONPRESCRIPTION DRUGS.Metoprolol: A selective adrenergic beta-1 blocking agent that is commonly used to treat ANGINA PECTORIS; HYPERTENSION; and CARDIAC ARRHYTHMIAS.Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.Molecular Structure: The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.Polysorbates: Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals.Gastrointestinal Tract: Generally refers to the digestive structures stretching from the MOUTH to ANUS, but does not include the accessory glandular organs (LIVER; BILIARY TRACT; PANCREAS).Amlodipine: A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.X-Ray Diffraction: The scattering of x-rays by matter, especially crystals, with accompanying variation in intensity due to interference effects. Analysis of the crystal structure of materials is performed by passing x-rays through them and registering the diffraction image of the rays (CRYSTALLOGRAPHY, X-RAY). (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Pharmacists: Those persons legally qualified by education and training to engage in the practice of pharmacy.Anti-Bacterial Agents: Substances that reduce the growth or reproduction of BACTERIA.Chromatography, Thin Layer: Chromatography on thin layers of adsorbents rather than in columns. The adsorbent can be alumina, silica gel, silicates, charcoals, or cellulose. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)Software: Sequential operating programs and data which instruct the functioning of a digital computer.Dogs: The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)Treatment Outcome: Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.Computer Simulation: Computer-based representation of physical systems and phenomena such as chemical processes.Emulsifying Agents: SURFACE-ACTIVE AGENTS that induce a dispersion of undissolved material throughout a liquid.Nanostructures: Materials which have structured components with at least one dimension in the range of 1 to 100 nanometers. These include NANOCOMPOSITES; NANOPARTICLES; NANOTUBES; and NANOWIRES.Ointments: Semisolid preparations used topically for protective emollient effects or as a vehicle for local administration of medications. Ointment bases are various mixtures of fats, waxes, animal and plant oils and solid and liquid hydrocarbons.Nanotechnology: The development and use of techniques to study physical phenomena and construct structures in the nanoscale size range or smaller.
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Dosage FormsTabletsChemistry, PharmaceuticalExcipientsDelayed-Action PreparationsDrug CompoundingCapsulesTechnology, PharmaceuticalDrug StabilityPharmaceutical SolutionsSolubilityPharmaceutical PreparationsMethylcellulosePowdersDrug CarriersTherapeutic EquivalencyBiological AvailabilityAdministration, OralDrug Delivery SystemsEmulsionsSuspensionsOrnidazoleParticle SizeTablets, Enteric-CoatedPowder DiffractionChromatography, Reverse-PhaseChromatography, High Pressure LiquidDrug StoragePolymethacrylic AcidsCalibrationSpectrophotometry, UltravioletGene DosageLimit of DetectionReproducibility of ResultsDosage Compensation, GeneticSkin AbsorptionNanoparticlesAdministration, TopicalOxprenololPharmacokineticsDrug CombinationsKetoprofenCarboxymethylcellulose SodiumPolymersFreeze DryingPoloxamerCalorimetry, Differential ScanningBiopharmaceuticsHumidityPovidoneDothiepinThermogravimetryChitosanGelsHexuronic AcidsHardnessGlucuronic AcidHydrogen-Ion ConcentrationMicrospheresCellulosebeta-CyclodextrinsAdministration, CutaneousDrug Administration RoutesAmebicidesIbuprofenMicroscopy, Electron, ScanningAbsorptionGlipizidePolyvinylsPolyglycolic AcidSurface-Active AgentsAlginatesAdhesivenessHalf-LifeVeterinary DrugsArea Under CurveViscosityDiclofenacLoratadineTime FactorsTriacetinDrug ContaminationAmbroxolDrug Evaluation, PreclinicalChlorpheniramineIndicators and ReagentsSensitivity and SpecificityFamotidinePolyethylene GlycolsIntestinal AbsorptionQuality ControlDesiccationCross-Over StudiesLiposomesGelatinPharmaceutical VehiclesAcrylic ResinsReference StandardsSolventsWaterPorosityTemperatureHospital Bed Capacity, 500 and overCarbonatesKineticsAnti-Inflammatory Agents, Non-SteroidalSpectroscopy, Fourier Transform InfraredAcetaminophenDose-Response Relationship, DrugDiffusionModels, BiologicalFlow Injection AnalysisAlgorithmsDrug DesignLinear ModelsPharmacopoeias as TopicUnited States Food and Drug AdministrationMorphinansModels, ChemicalLactoseMethanolAnalgesics, Non-NarcoticMetoprololHydrochlorothiazideMolecular StructurePolysorbatesGastrointestinal TractAmlodipineX-Ray DiffractionPharmacistsAnti-Bacterial AgentsChromatography, Thin LayerSoftwareDogsTreatment OutcomeComputer SimulationEmulsifying AgentsNanostructuresOintmentsNanotechnology
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... which are sold in India as branded formulations. Biocon's biosimilar products are also sold in both bulk and formulation forms ... Biocon has newly launched dosage forms like TACROGRAF 0.25 mg, RENODAPT 750 mg, to suit Indian patient needs through ideal ... An investigational new drug application (IND) with the US Food and Drug Administration was filed in December. T1h is a novel ... It has a rich insulin portfolio-comprising recombinant human insulin, insulin glargine (a long-acting basal insulin analogue), ...
LiposomeLiposome
... key elements comprise the foundation of an effective liposome carrier for use in increasing the bioavailability of oral dosages ... They typically form after supplying enough energy to a dispersion of (phospho)lipids in a polar solvent, such as water, to ... In addition to gene and drug delivery applications, liposomes can be used as carriers for the delivery of dyes to textiles, ... and type of raw phospholipid used in the formulation and manufacturing of the liposomes; (3) The ability to create homogeneous ...
Tablet (pharmacy)Tablet (pharmacy)
A tablet is a pharmaceutical dosage forms. Tablets may be defined as the solid unit dosage form of medicament or medicaments ... It comprises a mixture of active substances and excipients, usually in powder form, pressed or compacted from a powder into a ... or due to incorrect formulation: either because the tablet formulation is too brittle or not adhesive enough, or because the ... The process involves the application of heat, pressure and agitation to mix materials together and 'extrude' them through a die ...
ChemotherapyChemotherapy
The newly formed tumor vasculature is poorly formed and does not deliver an adequate blood supply to all areas of the tumor. ... Dosage[edit]. Dose response relationship of cell killing by chemotherapeutic drugs on normal and cancer cells. At high doses ... The building blocks are nucleotides; a molecule comprising a nucleobase, a sugar and a phosphate group. The nucleobases are ... Heller R, Gilbert R, Jaroszeski MJ (Jan 1999). "Clinical applications of electrochemotherapy". Advanced Drug Delivery Reviews. ...
FenofibrateFenofibrate
The active form of fenofibrate, fenofibric acid, is also available in the United States, sold as Trilipix. Fenofibric acid may ... Dosage adjustment of vitamin K antagonist may be necessary. Statins: Combination of statins and fenofibrate may increase the ... Fenofibrate is available in several formulations and is sold under several brand names, including Tricor by AbbVie, Lipofen by ... a prodrug comprising fenofibric acid linked to an isopropyl ester. It lowers lipid levels by activating peroxisome proliferator ...
ProbioticProbiotic
... treatment of bacterial vaginosis is the application or ingestion of bacterial species found in the healthy vagina to ... Some probiotics are suggested as a possible treatment for various forms of gastroenteritis, and a Cochrane Collaboration meta- ... For example, treatment with probiotic formulations including L. rhamnosus may reduce the risk of AAD, improve stool consistency ... The potential efficacy of probiotic AAD prevention depends on the probiotic strains and dosage. The Cochrane review (2015) ...
Prescription drug prices in the United StatesPrescription drug prices in the United States
In July 2016, the FDA generic drug application backlog comprised 4,036 generics. On the other hand, the European Medicine ... A generic drug form is required to have the same dose, strength and active ingredient(s) as the brand name drug; thus, they ... Another common way that people saved money, was to skip or reduce dosages or fail to fill a prescription entirely due to cost ... This could include by obtaining additional patents on other aspects of a drug, such as "its coating, salt moiety, formulation, ...
PharmacokineticsPharmacokinetics
This concept depends on a series of factors inherent to each drug, such as: Pharmaceutical form Chemical form Route of ... It is therefore necessary to adjust the dose or other treatment parameters when a high dosage is required. The kidneys can also ... The most common instrumentation used in this application is LC-MS with a triple quadrupole mass spectrometer. Tandem mass ... comprising organs and systems with a well-developed blood supply; and a peripheral compartment made up of organs with a lower ...
ChemotherapyChemotherapy
The newly formed tumor vasculature is poorly formed and does not deliver an adequate blood supply to all areas of the tumor. ... Dosage of chemotherapy can be difficult: If the dose is too low, it will be ineffective against the tumor, whereas, at ... Antibody-drug conjugates (ADCs) comprise an antibody, drug and a linker between them. The antibody will be targeted at a ... Electrochemotherapy is the combined treatment in which injection of a chemotherapeutic drug is followed by application of high- ...
Drug Master FileDrug Master File
... or finished drug dosage form. An Active Substance Master File (ASMF) is the currently recognised term in Europe, formerly known ... a New Drug Application (NDA),As an Abbreviated New Drug Application (ANDA), another DMF, or an Export Application. In United ... S.2.1 and P.3.1 Formulation Information (Usually applies to drug product only) P.1 and related sections Lot Release (batch ... ADVENTITIOUS AGENTS SAFETY EVALUATIONS STATEMENT OF COMMENT A drug master file comprises two parts: the Applicant's Part (USA: ...
PharmacokineticsPharmacokinetics
Liberation - the process of release of a drug from the pharmaceutical formulation.[4][5] See also IVIVC. ... Some textbooks combine the first two phases as the drug is often administered in an active form, which means that there is no ... Once a drug's bioavailability has been established it is possible to calculate the changes that need to be made to its dosage ... The most common instrumentation used in this application is LC-MS with a triple quadrupole mass spectrometer. Tandem mass ...
Food and Drug AdministrationFood and Drug Administration
... dosage form, strength, and pharmacokinetic properties ("bioequivalence") as the corresponding brand-name drug. This act has ... Each district comprises a main district office and a number of Resident Posts, which are FDA remote offices that serve a ... When its application to manufacture generics were subjected to repeated delays by the FDA, Mylan, convinced that it was being ... Through their governing of processes, however, the FDA does have a set of regulations that cover the formulation, manufacturing ...
PharmacologyPharmacology
The dosage of any drug approved for use is intended to fall within a range in which the drug produces a therapeutic effect or ... It needs to be determined how safe the medicine is for human consumption, its stability in the human body and the best form for ... Pharmacology can also focus on specific systems comprising the body. Divisions related to bodily systems study the effects of ... Pharmacogenomics is the application of genomic technologies to drug discovery and further characterization of drugs related to ...
Fine chemicalFine chemical
Formulation, i.e. conversion of the sensitive proteins to a stable form. All steps are fully automated. The low productivity of ... in both industrial applications, such as biocides and corrosion inhibitors in cooling water towers, and consumer applications, ... They comprise a reduction of in-house chemical manufacturing and plant eliminations. Outsourcing is moving up from a purely ... The biggest boom took place in the late 1990s, when high-dosage, high volume anti-AIDS drugs and COX-2 inhibitors gave a big ...
OpiumOpium
This form predominates in the U.S. west of the Mississippi. Relative to other preparations of heroin, it has been associated ... Nye, Gideon (1873). "The morning of my life in China : comprising an outline of the history of foreign intercourse from the ... Use of opium as a cure-all was reflected in the formulation of mithridatium described in the 1728 Chambers Cyclopedia, which ... which could be injected at a precisely controlled dosage. Opium has been actively collected since prehistoric times, though ...
EmulsionEmulsion
The first 5 are topical dosage forms, and may be used on the surface of the skin, transdermally, ophthalmically, rectally, or ... Over time, emulsions tend to revert to the stable state of the phases comprising the emulsion. An example of this is seen in ... For this reason, these nanoemulsions are not currently used intravenously (IV). The most effective application of this type of ... and which is continuous depends in many cases on the pharmaceutical formulation. These emulsions may be called creams, ...
PharmacologyPharmacology
The dosage of any drug approved for use is intended to fall within a range in which the drug produces a therapeutic effect or ... It needs to be determined how safe the medicine is for human consumption, its stability in the human body and the best form for ... Pharmacology can also focus on specific systems comprising the body. Divisions related to bodily systems study the effects of ... Pharmacogenomics is the application of genomic technologies to drug discovery and further characterization of drugs related to ...
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Dosage FormsTabletsChemistry, PharmaceuticalExcipientsDelayed-Action PreparationsDrug CompoundingCapsulesTechnology, PharmaceuticalDrug StabilityPharmaceutical SolutionsSolubilityPharmaceutical PreparationsMethylcellulosePowdersDrug CarriersTherapeutic EquivalencyBiological AvailabilityAdministration, OralDrug Delivery SystemsEmulsionsSuspensionsOrnidazoleParticle SizeTablets, Enteric-CoatedPowder DiffractionChromatography, Reverse-PhaseChromatography, High Pressure LiquidDrug StoragePolymethacrylic AcidsCalibrationSpectrophotometry, UltravioletGene DosageLimit of DetectionReproducibility of ResultsDosage Compensation, GeneticSkin AbsorptionNanoparticlesAdministration, TopicalOxprenololPharmacokineticsDrug CombinationsKetoprofenCarboxymethylcellulose SodiumPolymersFreeze DryingPoloxamerCalorimetry, Differential ScanningBiopharmaceuticsHumidityPovidoneDothiepinThermogravimetryChitosanGelsHexuronic AcidsHardnessGlucuronic AcidHydrogen-Ion ConcentrationMicrospheresCellulosebeta-CyclodextrinsAdministration, CutaneousDrug Administration RoutesAmebicidesIbuprofenMicroscopy, Electron, ScanningAbsorptionGlipizidePolyvinylsPolyglycolic AcidSurface-Active AgentsAlginatesAdhesivenessHalf-LifeVeterinary DrugsArea Under CurveViscosityDiclofenacLoratadineTime FactorsTriacetinDrug ContaminationAmbroxolDrug Evaluation, PreclinicalChlorpheniramineIndicators and ReagentsSensitivity and SpecificityFamotidinePolyethylene GlycolsIntestinal AbsorptionQuality ControlDesiccationCross-Over StudiesLiposomesGelatinPharmaceutical VehiclesAcrylic ResinsReference StandardsSolventsWaterPorosityTemperatureHospital Bed Capacity, 500 and overCarbonatesKineticsAnti-Inflammatory Agents, Non-SteroidalSpectroscopy, Fourier Transform InfraredAcetaminophenDose-Response Relationship, DrugDiffusionModels, BiologicalFlow Injection AnalysisAlgorithmsDrug DesignLinear ModelsPharmacopoeias as TopicUnited States Food and Drug AdministrationMorphinansModels, ChemicalLactoseMethanolAnalgesics, Non-NarcoticMetoprololHydrochlorothiazideMolecular StructurePolysorbatesGastrointestinal TractAmlodipineX-Ray DiffractionPharmacistsAnti-Bacterial AgentsChromatography, Thin LayerSoftwareDogsTreatment OutcomeComputer SimulationEmulsifying AgentsNanostructuresOintmentsNanotechnology
Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses Thereof - Patent...Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses Thereof - Patent...
Patent application title: Non-Intravenous Dosage Form Comprising Solid Formulation of Liquid Biologically Active Agent and Uses ... instant release dosage form, an immediate release dosage form, or a controlled release dosage form. 51. The dosage form ... The dosage form may be an instant release dosage form, an immediate release dosage form, or a controlled release dosage form. ... The dosage form may be an instant release dosage form, an immediate release dosage form, or a controlled release dosage form. ...
patentsencyclopedia.com
Modified release dosage form comprising desvenlafaxine or salts thereof - WOCKHARDT LIMITEDModified release dosage form comprising desvenlafaxine or salts thereof - WOCKHARDT LIMITED
The present invention refers to a modified release pharmaceutical composition comprising desvenlafaxine or salts thereof, a ... 2009). "Applications of Complementary Polymers in HPMC Hydrophilic Extended Release Matrices." Drug Delivery Technology, 9(7): ... In another embodiment, microcrystalline cellulose present in formulation is from about 1% to about 20% of the total weight of ... enhances the intactness of the dosage form, controls the rate of erosion of the dosage form and ensures the sustained release ...
freepatentsonline.com
Achieving Seamless Scale-Up and Technology Transfer - A Case Study in Single-UseAchieving Seamless Scale-Up and Technology Transfer - A Case Study in Single-Use
HME allows innovative formulations of solid oral dosage forms. Its main advantage in pharmaceutical applications is the ... Here the stability of various formulations comprising of GRAS excipients is also examined. ... It includes several case studies related to HME for solid oral dosage forms. In addition to solid oral dosage forms hot melt ... The processing of lipids via HME has been proved ideal for high drug loaded dosage forms with sustained release of drugs. The ...
brighttalk.com
Innovative solutions from Industry 4.0Innovative solutions from Industry 4.0
The processing of lipids via HME has been proved ideal for high drug loaded dosage forms with sustained release of drugs. The ... The stability of lipidic formulations is a very important aspect especially for paediatric applications. Here the stability of ... the slurry-to-slurry form transformation leading to the desired crystalline form, and the instability of API leading to ... HME lipidic Pellets for Paediatric Application. An Investigation of the Effect a Recorded: Jun 11 2019 43 mins Dennis Douroumis ...
brighttalk.com
Patent US5741512 - Pharmaceutical compositions comprising cyclosporins - Google PatentsPatent US5741512 - Pharmaceutical compositions comprising cyclosporins - Google Patents
Dosage forms include topical formulations and, in particular, oral dosage forms. ... and microemulsion form. The compositions typically comprise (1.1) a C1-5 alkyl or tetrahydrofurfuryl di- or partial-ether of a ... Compositions are also provided comprising a cyclosporin and (1.1) and, suitably, also a saccharide monoester, e.g. raffinose or ... Pharmaceutical compositions comprising a cyclosporin, e.g. Ciclosporin or Nva!2 -Ciclosporin, in microemulsion pre-concentrate ...
google.com
Bifeprunox mesylate maintenance dose compositions and methods for using the same - Eijgendaal, IreneBifeprunox mesylate maintenance dose compositions and methods for using the same - Eijgendaal, Irene
The present disclosure provides novel pharmaceutical dosage forms such as a maintenance treatment dose and methods for making ... and/or γ form) per dosage unit. Illustratively, such a dosage unit can comprise 0.125 mg, 1 mg, 5 mg, 10 mg, or 20 mg of ... Preparation of a 10 mg Capsule Formulation of Polymorphic Form α of Bifeprunox Mesylate. 2.227 kg of lactose was sieved and ... This application is a continuation-in-part of U.S. application Ser. No. 11/354,652, filed on Feb. 16, 2006, which claims the ...
freepatentsonline.com
Irina ErmolinaIrina Ermolina
In the present study, a number of formulations, which comprised bovine serum albumin (BSA) with and without L-arginine, and ... attract a great attention as this easy swallowing dosage form often improves patient compliance. In the current work, orally ... Application of Texture Analysis technique in formulation development of lyophilized orally disintegrating tablets containing ... Application of Texture Analysis technique in formulation development of lyophilized orally disintegrating tablets containing ...
dmu.ac.uk
Applications filed at Aug 11 2016 | USE OF COMPOSITIONS WITH A LOW POLYAMINE CONTENT IN THE PREVENTION OR TREATMENT OF...Applications filed at Aug 11 2016 | USE OF COMPOSITIONS WITH A LOW POLYAMINE CONTENT IN THE PREVENTION OR TREATMENT OF...
SOLUBILIZED FORMULATION OF COQ10 FOR USE IN TREATMENT OF PARKINSONS DISEASE , Pharmaceutical Formulation , PURIFIED CBD AND ... FORMULATIONS AND DOSAGE FORMS AND METHODS OF MAKING SAME. Novel compositions, formulations and dosage forms comprising ... Pharmaceutical Formulation. A pharmaceutical composition in the form of a tablet including a first portion and a second portion ... FIXATION OF VACCINE FORMULATIONS ON DEVICES FOR EPIDERMAL IMMUNISATION BY OILY ADJUVANTS. The present patent application ...
patents.com
Applications filed at Jun 08 2017 | Nanoparticulate Meloxicam Formulations | Patents.comApplications filed at Jun 08 2017 | Nanoparticulate Meloxicam Formulations | Patents.com
ORAL DOSAGE FORMS OF METHYL HYDROGEN FUMARATE AND PRODRUGS THEREOF , ... FORMULATIONS FOR ENHANCED BIOAVAILABILITY OF ORALLY ADMINISTERED POLAR AGENTS , ACID RESISTANT CAPSULE SHELL COMPOSITION, ACID ... ABUSE DETERRENT IMMEDIATE RELEASE COATED RESERVOIR SOLID DOSAGE FORM , ... TOPICAL SKIN CARE FORMULATIONS COMPRISING PLANT EXTRACTS. Disclosed are methods of treating skin with topical skin compositions ...
patents.com
Patent search - Patent Attorneys - Patent Applications - Patent SalePatent search - Patent Attorneys - Patent Applications - Patent Sale
Sustained-release formulation containing and amino acid polymer , vitamin D.sub.3 derivatives having a substituent at 2- ... Sustained-release formulation containing and amino acid polymer. A sustained-release polymeric hydrogel dosage form useful for ... Apparatus for cleaning and treating earlobes which have been pierced to form earring postholes comprising an elongated pinlike ... Microporous powder form polylactides. A microporous powder form polylactide which can take up a multiple of its own weight of ...
patents.com
Patent US6458827 - Method of locking 1α-OH of vitamin D compounds in axial orientation - Google PatentsPatent US6458827 - Method of locking 1α-OH of vitamin D compounds in axial orientation - Google Patents
The formulations may conveniently be presented in dosage unit form and may be prepared by any of the methods well known in the ... The formulations of the present invention comprise an active ingredient in association with a pharmaceutically acceptable ... or in the form of creams, ointments, patches, or similar vehicles suitable for transdermal applications. Doses of from 0.01 μg ... Formulations of the present invention suitable for oral administration may be in the form of discrete units as capsules, ...
google.com
US6083531A - Fast disintegrating oral dosage form - Google PatentsUS6083531A - Fast disintegrating oral dosage form - Google Patents
... which dosage form, however, does not contain agar; which dosage form is manufactured without applying any compression force to ... which dosage form disintegrates when taken into the mouth within 15 seconds. ... The present invention relates to a solid pharmaceutical dosage form for oral administration, consisting essentially of (a) at ... Formulations containing diclofenac, and methods of application thereof ES2302650B1 (en) 2007-01-11. 2009-02-16. Tedec-Meiji ...
patents.google.com
WO2009071097A1 - Use of hypothermia inducing drugs - Google PatentsWO2009071097A1 - Use of hypothermia inducing drugs - Google Patents
... of hypothermia in humans in a predictable and dose responsive fashion by use of a pharmaceutical composition comprising a ... Appropriate dosage forms for such administration, such as an aerosol formulation or a metered dose inhaler, may be prepared by ... Accordingly, the present invention further provides a pharmaceutical formulation, for medicinal application, which comprises a ... The compounds may be administered simultaneously, either as separate formulations or combined in a unit dosage form, or ...
patents.google.com
WHIPPED FORMULATIONS - BAYER HEALTHCARE LLCWHIPPED FORMULATIONS - BAYER HEALTHCARE LLC
... sufficient pressure to expel the formulation as a whipped formulation upon application of external force on the formulation in ... a formulation in a package. The formulation comprises one or more active agents and is co-mingled with a whipping agent prior ... The whipping agent is added in sufficient amounts to be dispersed in the formulation. The pressurized package is under ... sufficient pressure suitable to maintain the whipping agent dispersed in the formulation; and the pressurized package is under ...
sumobrain.com
PROCESS FOR PREPARING PRODUCTS COMPRISING STABILISED ACTIVES AND COMPOSITIONS COMPRISING SAME - KO, Sai YingPROCESS FOR PREPARING PRODUCTS COMPRISING STABILISED ACTIVES AND COMPOSITIONS COMPRISING SAME - KO, Sai Ying
The invention further relates to compositions comprising the products, and in particular compositions comprising therapeutic ... The present invention broadly relates to a process for preparing products comprising active components, and in particular ... The use of claim 29, wherein the product is in a dosage form selected from the group consisting of: a composition intended for ... In one embodiment, delivery formulations in accordance with the invention comprise proteins and peptides, preferably proteins ...
sumobrain.com
Ranitidine Loaded Biopolymer Floats: Designing, Characterization, and EvaluationRanitidine Loaded Biopolymer Floats: Designing, Characterization, and Evaluation
C. The lag time and TFT for each dosage form were also calculated. ... Therefore new formulations were designed to find the desired formulation, Tables 6-9. ... comprises both dissolvable and insoluble reswellable polysaccharides. Psyllium husk forms three-dimensional structures in ... In addition, it has many pharmaceutical applications and has been used in the treatment of numerous chronic infections [9-11]. ...
hindawi.com
Patent Docs: In re Kao (Fed. Cir. 2011)Patent Docs: In re Kao (Fed. Cir. 2011)
The subject matter was controlled-release oxymorphone formulations, assigned to Endo Pharmaceuticals Inc. in three applications ... U.S. Application Nos. 11/680,432 (Kao, Baichwal, McCall and Lee, inventors), 12/167,859 (Kao, Baichwal, McCall and Lee, ... The Federal Circuit continued its explication both of the contours of obviousness for pharmaceutical formulations after KSR ... a) providing a solid oral dosage form comprising about 5 mg to about 80 mg oxymorphone or a pharmaceutically acceptable salt ...
patentdocs.org
Patente US7749537 - Method of forming a tablet - Google PatentesPatente US7749537 - Method of forming a tablet - Google Patentes
... form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first ... A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness ... and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second ... Dosage form comprising fast agent delivery followed by slow agent delivery. US4871548. 17 Abr 1987. 3 Oct 1989. Alza ...
google.es
FORMULATIONS FOR ANIMAL FEED COMPRISING BUTYRATE SALT - Patent applicationFORMULATIONS FOR ANIMAL FEED COMPRISING BUTYRATE SALT - Patent application
Tamper resistant oral dosage forms. 2016-05-12. Nano-calcium phosphate-coated polymethylmethacrylate-based co-polymer and ... 1. Formulation for use in animal feed comprising coated granules comprising butyrate salt, the formulation further comprising ... Patent application title: FORMULATIONS FOR ANIMAL FEED COMPRISING BUTYRATE SALT. Inventors: Luc Goethals (Gijzenzele, BE) ... 0005] The invention thus provides for formulations comprising butyrate salt in granular form with other active ingredients. [ ...
patentsencyclopedia.com
Applications filed at Aug 18 2016 | COMPOSITIONS COMPRISING CITRULLINE AND LEUCINE AND THEIR USE IN THE TREATMENT OF...Applications filed at Aug 18 2016 | COMPOSITIONS COMPRISING CITRULLINE AND LEUCINE AND THEIR USE IN THE TREATMENT OF...
Compositions Comprising Enzyme-Cleavable Amphetamine Prodrugs and Inhibitors Thereof , ... Single oral solid dosage form comprising an immediate release first dosage composition having at least two antibiotic agents ... The present invention relates to a transdermal patch comprising a pharmaceutical formulation, the formulation comprising ... COMPOSITION IN FORM OF AN EMULSION. The present invention is a composition in form of an emulsion, comprising at least one ...
patents.com
Patent US9057675 - Methods of formulating and designing liquid drug suspensions containing ion ... - Google PatentsPatent US9057675 - Methods of formulating and designing liquid drug suspensions containing ion ... - Google Patents
In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. ... The invention relates to the formulation and quality control of liquid drug suspensions. ... Liquid oral dosage forms are known in the art. Liquid formulations have the distinct advantages of dosage flexibility and ease ... CROSS-REFERENCE TO RELATED APPLICATIONS. This application is a divisional of U.S. application Ser. No. 12/985,340, filed Jan. 5 ...
google.com.au
Japanese Patent Granted for Absorption Systems IDAS2™, a Uniquely Predictive Test System for Fundamental Drug Properties |...Japanese Patent Granted for Absorption Systems' IDAS2™, a Uniquely Predictive Test System for Fundamental Drug Properties |...
The primary claim in the patent application is a device for assessing drug dissolution, absorption and permeation, comprising a ... into a solid dosage form; and. the rate of permeation of the dissolved drug substance across a human intestinal cell monolayer ... the rate of dissolution, which is determined by the formulation and/or the manufacturing process used to incorporate the active ... is a unique test system that enables the simultaneous evaluation of drug dissolution and absorption in various dosage forms, ...
absorption.com
Patente US6489312 - Pharmaceutical formulations comprising aminoalkyl phosphorothioates - Google PatentesPatente US6489312 - Pharmaceutical formulations comprising aminoalkyl phosphorothioates - Google Patentes
The present invention provides novel pharmaceutical compositions comprising aminoalkyl phosphorothioate compounds in ... The remainder of the formulation may be provided as a sterile aqueous solution, or in lyophilized form. The single dosage form ... International Published Application WO 90/14007, published Nov. 29, 1990. Amifostine and its derivatives have been shown to ... The invention further provides sterile dosage forms wherein the formulation is provided in a lyophilized form, suitable for ...
google.es
Patent US6251859 - Deepithelialized skin diffusion cell system - Google PatentsPatent US6251859 - Deepithelialized skin diffusion cell system - Google Patents
The formulations provide slow release and increased contact time of fibronectin or other wound healing promoters to the wound ... A deepithelialized skin cell diffusion system which can be used to select topical gel and cream formulations containing human ... In one embodiment, the dosage form may comprise 0.01 to 1.0% by weight EDTA and/or 1.5 to 45.0 Inh U % by weight aprotinin ... RELATED APPLICATION. This application is divisional application of U.S. application Ser. No. 08/879,159 filed Jun. 19, 1997, ...
google.co.uk
US Patent Application for COMPOSITIONS AND METHODS FOR PREVENTING THE PROLIFERATION AND EPITHELIAL-MESENCHYMAL TRANSITION OF...US Patent Application for COMPOSITIONS AND METHODS FOR PREVENTING THE PROLIFERATION AND EPITHELIAL-MESENCHYMAL TRANSITION OF...
In some embodiments, the non-solid dosage form comprises combining the preparation with a delivery vehicle to create a ... The formulation used will depend upon the particular application. Gels are useful for administering the composition because ... the composition is in unit dosage forms suitable for single administration of precise amounts or dosages. In unit dosage form, ... In some embodiments, the composition is formulated as extended-release solid dosage forms (including oral dosage forms). ...
patents.justia.com
AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Dosage FormsTabletsChemistry, PharmaceuticalExcipientsDelayed-Action PreparationsDrug CompoundingCapsulesTechnology, PharmaceuticalDrug StabilityPharmaceutical SolutionsSolubilityPharmaceutical PreparationsMethylcellulosePowdersDrug CarriersTherapeutic EquivalencyBiological AvailabilityAdministration, OralDrug Delivery SystemsEmulsionsSuspensionsOrnidazoleParticle SizeTablets, Enteric-CoatedPowder DiffractionChromatography, Reverse-PhaseChromatography, High Pressure LiquidDrug StoragePolymethacrylic AcidsCalibrationSpectrophotometry, UltravioletGene DosageLimit of DetectionReproducibility of ResultsDosage Compensation, GeneticSkin AbsorptionNanoparticlesAdministration, TopicalOxprenololPharmacokineticsDrug CombinationsKetoprofenCarboxymethylcellulose SodiumPolymersFreeze DryingPoloxamerCalorimetry, Differential ScanningBiopharmaceuticsHumidityPovidoneDothiepinThermogravimetryChitosanGelsHexuronic AcidsHardnessGlucuronic AcidHydrogen-Ion ConcentrationMicrospheresCellulosebeta-CyclodextrinsAdministration, CutaneousDrug Administration RoutesAmebicidesIbuprofenMicroscopy, Electron, ScanningAbsorptionGlipizidePolyvinylsPolyglycolic AcidSurface-Active AgentsAlginatesAdhesivenessHalf-LifeVeterinary DrugsArea Under CurveViscosityDiclofenacLoratadineTime FactorsTriacetinDrug ContaminationAmbroxolDrug Evaluation, PreclinicalChlorpheniramineIndicators and ReagentsSensitivity and SpecificityFamotidinePolyethylene GlycolsIntestinal AbsorptionQuality ControlDesiccationCross-Over StudiesLiposomesGelatinPharmaceutical VehiclesAcrylic ResinsReference StandardsSolventsWaterPorosityTemperatureHospital Bed Capacity, 500 and overCarbonatesKineticsAnti-Inflammatory Agents, Non-SteroidalSpectroscopy, Fourier Transform InfraredAcetaminophenDose-Response Relationship, DrugDiffusionModels, BiologicalFlow Injection AnalysisAlgorithmsDrug DesignLinear ModelsPharmacopoeias as TopicUnited States Food and Drug AdministrationMorphinansModels, ChemicalLactoseMethanolAnalgesics, Non-NarcoticMetoprololHydrochlorothiazideMolecular StructurePolysorbatesGastrointestinal TractAmlodipineX-Ray DiffractionPharmacistsAnti-Bacterial AgentsChromatography, Thin LayerSoftwareDogsTreatment OutcomeComputer SimulationEmulsifying AgentsNanostructuresOintmentsNanotechnology
CompositionTabletsFurther comprisesPharmaceutically acceptableRelatesThereofTherapeuticExcipientsAqueousPolymericAccording to claim 10Controlled-release oxymorphone formulationsOralHydrophobicPreferred embodimentsPolymersPolymerTherapeutically2016PatentSuitableMedicinalTablet formulationsExtended-releaseCompoundCompoundsExcipientSaltsCapsulesSolidDissolutionTransdermal patchClaimsStabilityOrallyPreparationsPreferablyGranules compriseSustained release formulationParticlesMethodsHydrogelNanoparticulateNanoparticlesCompositions and dosage formsSuppositoriesActive IngredientsNovel FormulationsCapsuleDevelopmentInjectableWater-solubleClaim
Composition30
Tablets20
Further comprises1
  • 10. The kit of claim 8 further comprises at least one other agent for use in the treatment of pain or a neurological disorder. (google.nl)
Pharmaceutically acceptable6
Relates16
Thereof4
  • e. putting the droplets resulting from step d into a column of an oil, which is immiscible with the mixture resulting from step c and has a lower specific density than the specific density of the mixture resulting from step c, at the top thereof to form a plurality of microspheres each of which encapsulates some of said living tissue cells. (google.ca)
  • The present disclosure is directed to generally methods for treating mammographic breast density and/or breast stiffness in a patient in need thereof, such as a premenopausal or perimenopausal patient, comprising the administration of an effective amount of androgenic agent and an effective amount of an aromatase inhibitor. (rpxcorp.com)
  • The present invention pertains to a cell culture medium comprising manganese as a media supplement that was shown to control recombinant protein antennarity and/or glycosylation and methods of using thereof. (wipo.int)
  • 19. Amphetamine in the form of L-lysine-d-amphetamine or a mesylate or hydrochloride salt thereof for use in decreasing abuse of amphetamines or salts thereof, in a subject in need thereof. (epo.org)
Therapeutic7
Excipients11
Aqueous7
Polymeric3
According to claim 101
Controlled-release oxymorphone formulations2
Oral21
Hydrophobic2
Preferred embodiments1
  • The Examiner, affirmed by the Board, rejected these arguments and distinctions, finding that the claims were obvious because the Maloney reference disclosed oxymorphone formulations as 'preferred embodiments' and the dissolution rates in the reference overlapped with the range of rates in the '432 application claims. (patentdocs.org)
Polymers9
Polymer4
Therapeutically1
20162
  • No. 15/160,487, filed on May 20, 2016, which claims the benefit of and right of priority to U.S. Provisional Application No. 62/164,281 filed May 20, 2015, both of which are incorporated herein by reference in their entireties. (justia.com)
  • It accounted for over 45% of the total revenue in 2016 and almost 40% of the overall volume used in pharmaceutical formulations. (grandviewresearch.com)
Patent21
  • At Patents you can conduct a Patent Search, File a Patent Application, find a Patent Attorney, or search available technology through our Patent Exchange. (patents.com)
  • The Federal Circuit continued its explication both of the contours of obviousness for pharmaceutical formulations after KSR Int'l Co. v. Teleflex Inc. as well as how it exercises its supervisory powers over the U.S. Patent and Trademark Office after Dickinson v. Zurko , in a decision last Friday, In re Huai-Hunk Kao et al . (patentdocs.org)
  • The three applications rejected by the U.S. Patent and Trademark Office provided controlled-release formulations that overcame these limitations. (patentdocs.org)
  • The primary claim in the patent application is a device for assessing drug dissolution, absorption and permeation, comprising a reservoir (for dissolution) with fluid bathing a permeability barrier composed of living human intestinal cells. (absorption.com)
  • I. European patent application No. 01 201 824.8 published as EP 1 147 771 is a divisional application of the parent application No. 96 930 817.0, which was filed as international application WO 97/09042. (epo.org)
  • The appeal lies from a decision of the examining division refusing the patent application under Article 97(1) EPC. (epo.org)
  • This application claims the benefit under 35 U. S. C. § 119(e) of U.S. Provisional Patent Application No. 60/904,456 filed March 2, 2007, where this provisional application is incorporated herein by reference in its entirety. (lens.org)
  • In Cubist the Federal Circuit held that the patentee failed to establish the required nexus between the commercial success of the commercial embodiment (an antiobiotic formulation comprising daptomycin, brand name Cubicin®), and the novel aspects of the patent claims at issue. (ipwatchdog.com)
  • US Patent 4,576,284 specifically discloses such capsules provided with a cap which closes the capsule, and which is formed in situ on the filled capsule by molding. (allindianpatents.com)
  • This application is a Continuation of and claims the benefit of priority of U.S. patent application Ser. (lens.org)
  • Patent application Wfor instance, discloses a solid dosage form comprising a compacted fill material containing at least one active agent and at least one of a disintegrating agent and wetting agent. (antibioticshelp.life)
  • It comprises formulations of ointments, creams, gels, and suppositories, from publicly on hand yet generally dispersed details from FDA New Drug purposes (NDA), patent functions, and different resources of popular and proprietary formulations. (magomechaya.com)
  • I. European patent No. 1 644 019 based on application No. 04 753 925.9 was granted on the basis of a set of 30 claims. (epo.org)
  • Three oppositions were filed against the patent under Article 100(a), (b) and (c) EPC on the grounds that its subject-matter lacked novelty and inventive step and covered a method of treatment, was not sufficiently disclosed, and extended beyond the content of the application as filed. (epo.org)
  • Novartis, its fellow Big Pharma multinationals, Chambers of Commerce, and PhRMA have all roundly denounced India's Supreme Court's decision invalidating Novartis' patent application for Glivec (Gleevec in the United States) and its affirmation of strict anti-evergreening standards of patentability and inventive step in India. (healthgap.org)
  • Accordingly, India was under no obligation whatsoever to recognize this first application, not only because a patent application on it was never filed in India but because India had lawfully declined to grant pharmaceutical product patents at the time of invention. (healthgap.org)
  • Thus, it is completely irrelevant that other countries granted patents on the first Glivec patent application. (healthgap.org)
  • Myth 2: India was obligated to issue a patent on Glivec's "improved beta crystalline form of imatinib mesylate" discovered/invented in 1997 because it was a new medicine and 40 other countries granted a patent. (healthgap.org)
  • The "beta crystalline" patent application that Novartis filed in India in 1998, with a 1997 priority date, fell squarely in the middle of the prohibited category. (healthgap.org)
  • The lawsuit arose when Roxane and co-Defendants Mylan Pharmaceuticals, Inc., and Teva Pharmaceuticals USA, Inc. each filed an Abbreviated New Drug Application (ANDA) for Acorda's multiple sclerosis drug (Ampyra®) and sent Paragraph IV letters to Acorda (and co-Plaintiff Alkermes Pharma Ireland Ltd.) asserting that four Orange Book-listed patents (U.S. Patent Nos. (patentdocs.org)
  • Acorda's patents were for more narrow formulations having specific characteristics and properties that distinguished (undisputedly, for novelty purposes) these claims from the claims of the '938 patent. (patentdocs.org)
Suitable6
Medicinal5
Tablet formulations2
  • These highly portable dosage forms offer an attractive alternative to tablet formulations, especially populations that have difficulty swallowing, such as geriatric and pediatric patients. (spipharma.com)
  • For this purpose, this paper reports the development and validation of a simple, sensitive, accurate and reproducible agar diffusion method to quantify orbifloxacin in tablet formulations. (mdpi.com)
Extended-release2
Compound5
  • 7. A method of treating metabolic bone disease where it is desired to maintain or increase bone mass comprising administering to a patient with said disease an effective amount of a compound as claimed in claim 1 . (google.com)
  • 20. A method of treating a disease having by abnormal cell proliferation or cell differentiation comprising administering to a patient with said disease an effective amount of a compound as claimed in claim 1 . (google.com)
  • 24. A method of treating a disease having by an imbalance in the immune system comprising administering to a patient with said disease an effective amount of a compound as claimed in claim 1 . (google.com)
  • 8. A kit for treating pain or a neurological disorder in a subject, the kit comprising the compound of claim 1 , and instructions for using the kit. (google.nl)
  • This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering ALK inhibitors. (gc.ca)
Compounds7
Excipient2
Salts1
  • Moreover, advanced formulations (i.e., co-crystals and in situ salts) or structured products (i.e., by co-extrusion) can be obtained. (pssrc.org)
Capsules1
Solid11
Dissolution2
  • According to the Examiner, the Maloney reference discloses every element of the claim except the dissolution rate, and the Examiner required Applicants to demonstrate that the practice of the formulations disclosed by Maloney did not (inherently? (patentdocs.org)
  • The examining division defined document (8) to be the closest prior art, in particular the sachet disclosed in Example 3 comprising amoxycillin and clavulanate in a ratio of 12:1 in a dry powder formulation for dissolution. (epo.org)
Transdermal patch2
Claims7
  • All the applications had been filed under the PTO's Accelerated Examination Program, which limited the claims that were argued on appeal. (patentdocs.org)
  • This application claims the benefit of U.S. Provisional Application No. 61/103,800, filed Oct. 8, 2008, which application is incorporated herein by reference. (google.nl)
  • 2015). The relevant claims were directed to certain dosing regimens for the administration of daptomycin-containing formulations. (ipwatchdog.com)
  • The application is the national stage under 35 U.S.C. § 371 of PCT International Application No. PCT/US2012/049842, filed Aug. 7, 2012, which claims the benefit of priority of U.S. Provisional Application Nos. (justia.com)
  • No. 11/839,515, filed on Aug. 15, 2007, now abandoned, which claims the benefit of priority under 35 U.S.C. §119 of ES Application No. P200602218, filed Aug. 16, 2006 and of ES Application No. P200701856, filed Jul. (lens.org)
  • Novartis claims in its press statements that because Glivec was never marketed using imatinib in its original form and that its beta crystalline form was not a modification of an existing medicine is specious. (healthgap.org)
  • Claims priority, application France June 21, 1957 The hydrochloric acid set vfree during the oxidizing con~ 10 2 Claims. (docme.ru)
Stability3
  • This clearly shows that, after HME, a variety of additional processing steps are required, which may affect the final dosage form performance and stability. (pssrc.org)
  • In the present study, stability indicating HPLC method was developed for the determination of strychnine in Ayurvedic formulation Krimimudgara Rasa (KMR) 8 . (ijpsr.com)
  • Marina's main focus is characterization of vaccine components, specifically, protein conformation and stability in solution and in adjuvanted form, analysis of raw materials, particle sizing technologies, and inline PAT applications. (mt.com)
Orally3
  • it cures pharyngitis when sucked, eliminates abdominal distension when ground and taken orally, relieves female abdominal distention due to blood stasis when taken with wine, and treats baldness and bites (snake, dog, or spider) when squeezed to get a juice for application to the affected site. (itmonline.org)
  • Pharmasperse 416 orally dispersible platform is specifically engineered for the ready manufacture of orally dispersible powder (ODP) formulations intended for filling into sachets or stickpacks. (spipharma.com)
  • PISCATAWAY, N.J., Sept. 19, 2012 /PRNewswire/ -- InnoPharma, Inc . today announced U.S. FDA approval of their Abbreviated New Drug Application (ANDA) for Acetylcysteine Solution, USP, a bronchial mucolytic indicated as an adjuvant therapy for patients with certain lung diseases and also as an acetaminophen antidote when administered orally. (bio-medicine.org)
Preparations1
Preferably1
  • Sustained release formulations are more preferably applied for patients on chronic medication where one administration suffices to maintain active blood plasma levels for longer periods such as several days or even weeks. (lens.org)
Granules comprise2
Sustained release formulation2
  • A sustained release formulation is often not feasible as a tablet or capsule due to their unacceptably large size. (lens.org)
  • For example, for a drug that is administered 3 times a day at 500 mg each time in a non-sustained release formulation, a once-a-day dose (i.e., 1500 mg) would result in a bulky tablet with a total weight of greater than 2-3 grams. (lens.org)
Particles2
Methods7
Hydrogel1
Nanoparticulate1
Nanoparticles2
  • Lastly, and in parallel, the development of functionalized and dual-loaded AcDXSp nanoparticles for potential application in cellular reprogramming was proven successful, by utilizing acidic pH-triggered drug delivery of the two poorly water-soluble cargos. (helsinki.fi)
  • In this work, plasmids for the CRISPR-Cas9 system were encapsulated in nanoparticles comprised of PLGA and were shown to induce expression of bacterial Cas9 in murine bone marrow derived macrophages in vitro. (springer.com)
Compositions and dosage forms1
Suppositories4
Active Ingredients5
Novel Formulations1
Capsule1
Development11
  • In the work, great emphasis was placed on illustrating the applicability of the Texture Analysis of the freeze-dried cakes directly in vials in formulation development. (dmu.ac.uk)
  • for drug substances in these classes, IDAS2 could be particularly impactful in the development and/or selection of formulations with a higher probability of success in clinical BE studies. (absorption.com)
  • The examining division considered that the whole development illustrated by a number of prior art documents clearly showed a tendency towards increased amounts of amoxycillin relative to clavulanate, and that it was therefore within the normal routine of a skilled person to adapt the existing formulations in this direction to arrive at a ratio of 14:1, even in the case of paediatric patients. (epo.org)
  • Assay method development is very significant for pharmaceutical industries and pathological laboratories, and this is always desirable to select and develop simple, accurate, precise, and economical method for the determination of drugs in pharmaceutical dosage forms and pathological samples. (hindawi.com)
  • Business activities comprise formulation development, scale-up and manufacture of clinical trial supplies or finished products under full cGMP conditions. (enhancedonlinenews.com)
  • They are also engaged in the development of such formulations. (grandviewresearch.com)
  • Moreover it focuses on the key Flat Glass manufacturers and studies the applications, end-users, market share and development plans in next few years. (medgadget.com)
  • Sagent has created a unique, global network of resources, comprised of rapid development capabilities, sophisticated manufacturing and innovative drug-delivery technologies, quickly yielding an extensive portfolio of pharmaceutical products that fulfills the evolving needs of patients. (bio-medicine.org)
  • InnoPharma is a sterile product development company, focused on developing niche generic and innovative specialty pharmaceutical products in injectable and ophthalmic dosage forms. (bio-medicine.org)
  • Dr Andreas Wagner (Vienna, AT) informed on "Guiding liposomal therapeutics to clinical evaluation-points to consider in formulation and process development" and highlighted the quality aspects of phospholipids, process validation, analytics etc. in the GMP production of parenteral phospholipid based formulations. (phospholipid-institute.com)
  • C. ELAN is beneficially entitled to the use of various patents, including the ELAN PATENTS, which have been granted or are pending under the International Convention in relation to the development and production of drug specific dosage forms for pharmaceutical products and processes. (onecle.com)
Injectable1
Water-soluble1
Claim5