Plasma glycoprotein member of the serpin superfamily which inhibits TRYPSIN; NEUTROPHIL ELASTASE; and other PROTEOLYTIC ENZYMES.
One of the two major pharmacological subdivisions of adrenergic receptors that were originally defined by the relative potencies of various adrenergic compounds. The alpha receptors were initially described as excitatory receptors that post-junctionally stimulate SMOOTH MUSCLE contraction. However, further analysis has revealed a more complex picture involving several alpha receptor subtypes and their involvement in feedback regulation.
Hypoxia-inducible factor 1, alpha subunit is a basic helix-loop-helix transcription factor that is regulated by OXYGEN availability and is targeted for degradation by VHL TUMOR SUPPRESSOR PROTEIN.
A member of the NICOTINIC ACETYLCHOLINE RECEPTOR subfamily of the LIGAND-GATED ION CHANNEL family. It consists entirely of pentameric a7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen.
Cell surface receptor for LAMININ, epiligrin, FIBRONECTINS, entactin, and COLLAGEN. Integrin alpha3beta1 is the major integrin present in EPITHELIAL CELLS, where it plays a role in the assembly of BASEMENT MEMBRANE as well as in cell migration, and may regulate the functions of other integrins. Two alternatively spliced isoforms of the alpha subunit (INTEGRIN ALPHA3), are differentially expressed in different cell types.
An integrin alpha subunit that is unique in that it does not contain an I domain, and its proteolytic cleavage site is near the middle of the extracellular portion of the polypeptide rather than close to the membrane as in other integrin alpha subunits.
An integrin alpha subunit that primarily associates with INTEGRIN BETA1 or INTEGRIN BETA4 to form laminin-binding heterodimers. Integrin alpha6 has two alternatively spliced isoforms: integrin alpha6A and integrin alpha6B, which differ in their cytoplasmic domains and are regulated in a tissue-specific and developmental stage-specific manner.
An integrin found in FIBROBLASTS; PLATELETS; MONOCYTES, and LYMPHOCYTES. Integrin alpha5beta1 is the classical receptor for FIBRONECTIN, but it also functions as a receptor for LAMININ and several other EXTRACELLULAR MATRIX PROTEINS.
Integrin alpha4beta1 is a FIBRONECTIN and VCAM-1 receptor present on LYMPHOCYTES; MONOCYTES; EOSINOPHILS; NK CELLS and thymocytes. It is involved in both cell-cell and cell- EXTRACELLULAR MATRIX adhesion and plays a role in INFLAMMATION, hematopoietic cell homing and immune function, and has been implicated in skeletal MYOGENESIS; NEURAL CREST migration and proliferation, lymphocyte maturation and morphogenesis of the PLACENTA and HEART.
An interleukin-1 subtype that occurs as a membrane-bound pro-protein form that is cleaved by proteases to form a secreted mature form. Unlike INTERLEUKIN-1BETA both membrane-bound and secreted forms of interleukin-1alpha are biologically active.
An integrin found on fibroblasts, platelets, endothelial and epithelial cells, and lymphocytes where it functions as a receptor for COLLAGEN and LAMININ. Although originally referred to as the collagen receptor, it is one of several receptors for collagen. Ligand binding to integrin alpha2beta1 triggers a cascade of intracellular signaling, including activation of p38 MAP kinase.
A subclass of alpha-adrenergic receptors that mediate contraction of SMOOTH MUSCLE in a variety of tissues such as ARTERIOLES; VEINS; and the UTERUS. They are usually found on postsynaptic membranes and signal through GQ-G11 G-PROTEINS.
This integrin alpha subunit combines with INTEGRIN BETA1 to form a receptor (INTEGRIN ALPHA5BETA1) that binds FIBRONECTIN and LAMININ. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds.
Integrin alpha1beta1 functions as a receptor for LAMININ and COLLAGEN. It is widely expressed during development, but in the adult is the predominant laminin receptor (RECEPTORS, LAMININ) in mature SMOOTH MUSCLE CELLS, where it is important for maintenance of the differentiated phenotype of these cells. Integrin alpha1beta1 is also found in LYMPHOCYTES and microvascular endothelial cells, and may play a role in angiogenesis. In SCHWANN CELLS and neural crest cells, it is involved in cell migration. Integrin alpha1beta1 is also known as VLA-1 and CD49a-CD29.
A subclass of alpha-adrenergic receptors found on both presynaptic and postsynaptic membranes where they signal through Gi-Go G-PROTEINS. While postsynaptic alpha-2 receptors play a traditional role in mediating the effects of ADRENERGIC AGONISTS, the subset of alpha-2 receptors found on presynaptic membranes signal the feedback inhibition of NEUROTRANSMITTER release.
A cell surface receptor mediating cell adhesion to the EXTRACELLULAR MATRIX and to other cells via binding to LAMININ. It is involved in cell migration, embryonic development, leukocyte activation and tumor cell invasiveness. Integrin alpha6beta1 is the major laminin receptor on PLATELETS; LEUKOCYTES; and many EPITHELIAL CELLS, and ligand binding may activate a number of signal transduction pathways. Alternative splicing of the cytoplasmic domain of the alpha6 subunit (INTEGRIN ALPHA6) results in the formation of A and B isoforms of the heterodimer, which are expressed in a tissue-specific manner.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
This intrgrin is a key component of HEMIDESMOSOMES and is required for their formation and maintenance in epithelial cells. Integrin alpha6beta4 is also found on thymocytes, fibroblasts, and Schwann cells, where it functions as a laminin receptor (RECEPTORS, LAMININ) and is involved in wound healing, cell migration, and tumor invasiveness.
The alpha subunits of integrin heterodimers (INTEGRINS), which mediate ligand specificity. There are approximately 18 different alpha chains, exhibiting great sequence diversity; several chains are also spliced into alternative isoforms. They possess a long extracellular portion (1200 amino acids) containing a MIDAS (metal ion-dependent adhesion site) motif, and seven 60-amino acid tandem repeats, the last 4 of which form EF HAND MOTIFS. The intracellular portion is short with the exception of INTEGRIN ALPHA4.
A family of transmembrane glycoproteins (MEMBRANE GLYCOPROTEINS) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including EXTRACELLULAR MATRIX PROTEINS; COMPLEMENT, and other cells, while their intracellular domains interact with the CYTOSKELETON. The integrins consist of at least three identified families: the cytoadhesin receptors(RECEPTORS, CYTOADHESIN), the leukocyte adhesion receptors (RECEPTORS, LEUKOCYTE ADHESION), and the VERY LATE ANTIGEN RECEPTORS. Each family contains a common beta-subunit (INTEGRIN BETA CHAINS) combined with one or more distinct alpha-subunits (INTEGRIN ALPHA CHAINS). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; HEMOSTASIS; THROMBOSIS; WOUND HEALING; immune and nonimmune defense mechanisms; and oncogenic transformation.
An integrin alpha subunit that binds COLLAGEN and LAMININ though its I domain. It combines with INTEGRIN BETA1 to form the heterodimer INTEGRIN ALPHA1BETA1.
Brain waves characterized by a relatively high voltage or amplitude and a frequency of 8-13 Hz. They constitute the majority of waves recorded by EEG registering the activity of the parietal and occipital lobes when the individual is awake, but relaxed with the eyes closed.
An integrin alpha subunit that occurs as alternatively spliced isoforms. The isoforms are differentially expressed in specific cell types and at specific developmental stages. Integrin alpha3 combines with INTEGRIN BETA1 to form INTEGRIN ALPHA3BETA1 which is a heterodimer found primarily in epithelial cells.
Deficiency of the protease inhibitor ALPHA 1-ANTITRYPSIN that manifests primarily as PULMONARY EMPHYSEMA and LIVER CIRRHOSIS.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
One of the two major classes of cholinergic receptors. Nicotinic receptors were originally distinguished by their preference for NICOTINE over MUSCARINE. They are generally divided into muscle-type and neuronal-type (previously ganglionic) based on pharmacology, and subunit composition of the receptors.
Drugs that selectively bind to and activate alpha adrenergic receptors.
A nuclear transcription factor. Heterodimerization with RETINOID X RECEPTOR GAMMA is important to metabolism of LIPIDS. It is the target of FIBRATES to control HYPERLIPIDEMIAS.
A naturally occurring prostaglandin that has oxytocic, luteolytic, and abortifacient activities. Due to its vasocontractile properties, the compound has a variety of other biological actions.
Drugs that bind to but do not activate alpha-adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists. Adrenergic alpha-antagonists are used in the treatment of hypertension, vasospasm, peripheral vascular disease, shock, and pheochromocytoma.
Proteins prepared by recombinant DNA technology.
Hepatocyte nuclear factor 1-alpha is a transcription factor found in the LIVER; PANCREAS; and KIDNEY that regulates HOMEOSTASIS of GLUCOSE.
The parts of a macromolecule that directly participate in its specific combination with another molecule.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Glycoprotein found in alpha(1)-globulin region in human serum. It inhibits chymotrypsin-like proteinases in vivo and has cytotoxic killer-cell activity in vitro. The protein also has a role as an acute-phase protein and is active in the control of immunologic and inflammatory processes, and as a tumor marker. It is a member of the serpin superfamily.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The rate dynamics in chemical or physical systems.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-1 RECEPTORS.
Nucleocytoplasmic transport molecules that bind to the NUCLEAR LOCALIZATION SIGNALS of cytoplasmic molecules destined to be imported into the CELL NUCLEUS. Once attached to their cargo they bind to BETA KARYOPHERINS and are transported through the NUCLEAR PORE COMPLEX. Inside the CELL NUCLEUS alpha karyopherins dissociate from beta karypherins and their cargo. They then form a complex with CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN and RAN GTP-BINDING PROTEIN which is exported to the CYTOPLASM.
Compounds and molecular complexes that consist of very large numbers of atoms and are generally over 500 kDa in size. In biological systems macromolecular substances usually can be visualized using ELECTRON MICROSCOPY and are distinguished from ORGANELLES by the lack of a membrane structure.
Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS.
The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.
Single chains of amino acids that are the units of multimeric PROTEINS. Multimeric proteins can be composed of identical or non-identical subunits. One or more monomeric subunits may compose a protomer which itself is a subunit structure of a larger assembly.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
The relationship between the dose of an administered drug and the response of the organism to the drug.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Regulatory proteins that act as molecular switches. They control a wide range of biological processes including: receptor signaling, intracellular signal transduction pathways, and protein synthesis. Their activity is regulated by factors that control their ability to bind to and hydrolyze GTP to GDP. EC 3.6.1.-.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
The level of protein structure in which combinations of secondary protein structures (alpha helices, beta sheets, loop regions, and motifs) pack together to form folded shapes called domains. Disulfide bridges between cysteines in two different parts of the polypeptide chain along with other interactions between the chains play a role in the formation and stabilization of tertiary structure. Small proteins usually consist of only one domain but larger proteins may contain a number of domains connected by segments of polypeptide chain which lack regular secondary structure.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
An imidazoline sympatholytic agent that stimulates ALPHA-2 ADRENERGIC RECEPTORS and central IMIDAZOLINE RECEPTORS. It is commonly used in the management of HYPERTENSION.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
A plant alkaloid with alpha-2-adrenergic blocking activity. Yohimbine has been used as a mydriatic and in the treatment of ERECTILE DYSFUNCTION.
The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
A soluble factor produced by MONOCYTES; MACROPHAGES, and other cells which activates T-lymphocytes and potentiates their response to mitogens or antigens. Interleukin-1 is a general term refers to either of the two distinct proteins, INTERLEUKIN-1ALPHA and INTERLEUKIN-1BETA. The biological effects of IL-1 include the ability to replace macrophage requirements for T-cell activation.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Compounds that bind to and activate ADRENERGIC ALPHA-2 RECEPTORS.
The degree of similarity between sequences of amino acids. This information is useful for the analyzing genetic relatedness of proteins and species.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A family of heterotrimeric GTP-binding protein alpha subunits that were originally identified by their ability to inhibit ADENYLYL CYCLASES. Members of this family can couple to beta and gamma G-protein subunits that activate POTASSIUM CHANNELS. The Gi-Go part of the name is also spelled Gi/Go.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Electrophoresis in which a polyacrylamide gel is used as the diffusion medium.
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Drugs that bind to and block the activation of ADRENERGIC ALPHA-2 RECEPTORS.
Elements of limited time intervals, contributing to particular results or situations.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Peptide elongation factor 1 is a multisubunit protein that is responsible for the GTP-dependent binding of aminoacyl-tRNAs to eukaryotic ribosomes. The alpha subunit (EF-1alpha) binds aminoacyl-tRNA and transfers it to the ribosome in a process linked to GTP hydrolysis. The beta and delta subunits (EF-1beta, EF-1delta) are involved in exchanging GDP for GTP. The gamma subunit (EF-1gamma) is a structural component.
A cell line derived from cultured tumor cells.
Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques.
A subfamily of nuclear receptors that regulate GENETIC TRANSCRIPTION of a diverse group of GENES involved in the synthesis of BLOOD COAGULATION FACTORS; and in GLUCOSE; CHOLESTEROL; and FATTY ACIDS metabolism.
Structurally related forms of an enzyme. Each isoenzyme has the same mechanism and classification, but differs in its chemical, physical, or immunological characteristics.
Models used experimentally or theoretically to study molecular shape, electronic properties, or interactions; includes analogous molecules, computer-generated graphics, and mechanical structures.
Cell surface proteins which bind GAMMA-AMINOBUTYRIC ACID and contain an integral membrane chloride channel. Each receptor is assembled as a pentamer from a pool of at least 19 different possible subunits. The receptors belong to a superfamily that share a common CYSTEINE loop.
(9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Genetically engineered MUTAGENESIS at a specific site in the DNA molecule that introduces a base substitution, or an insertion or deletion.
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
A condition of decreased oxygen content at the cellular level.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.
Drugs that bind to nicotinic cholinergic receptors (RECEPTORS, NICOTINIC) and block the actions of acetylcholine or cholinergic agonists. Nicotinic antagonists block synaptic transmission at autonomic ganglia, the skeletal neuromuscular junction, and at central nervous system nicotinic synapses.
Antibodies produced by a single clone of cells.
The relationship between the chemical structure of a compound and its biological or pharmacological activity. Compounds are often classed together because they have structural characteristics in common including shape, size, stereochemical arrangement, and distribution of functional groups.
The interaction of two or more substrates or ligands with the same binding site. The displacement of one by the other is used in quantitative and selective affinity measurements.
A family of heterotrimeric GTP-binding protein alpha subunits that activate ADENYLYL CYCLASES.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Drugs that bind to and activate nicotinic cholinergic receptors (RECEPTORS, NICOTINIC). Nicotinic agonists act at postganglionic nicotinic receptors, at neuroeffector junctions in the peripheral nervous system, and at nicotinic receptors in the central nervous system. Agents that function as neuromuscular depolarizing blocking agents are included here because they activate nicotinic receptors, although they are used clinically to block nicotinic transmission.
Heparin-binding proteins that exhibit a number of inflammatory and immunoregulatory activities. Originally identified as secretory products of MACROPHAGES, these chemokines are produced by a variety of cell types including NEUTROPHILS; FIBROBLASTS; and EPITHELIAL CELLS. They likely play a significant role in respiratory tract defenses.
Specific cell surface receptors which bind to FIBRONECTINS. Studies have shown that these receptors function in certain types of adhesive contact as well as playing a major role in matrix assembly. These receptors include the traditional fibronectin receptor, also called INTEGRIN ALPHA5BETA1 and several other integrins.
The sequence of carbohydrates within POLYSACCHARIDES; GLYCOPROTEINS; and GLYCOLIPIDS.
A 38-kDa mitogen-activated protein kinase that is abundantly expressed in a broad variety of cell types. It is involved in the regulation of cellular stress responses as well as the control of proliferation and survival of many cell types. The kinase activity of the enzyme is inhibited by the pyridinyl-imidazole compound SB 203580.
Enzymes catalyzing the transfer of fucose from a nucleoside diphosphate fucose to an acceptor molecule which is frequently another carbohydrate, a glycoprotein, or a glycolipid molecule. Elevated activity of some fucosyltransferases in human serum may serve as an indicator of malignancy. The class includes EC; EC; EC; EC
The lipid- and protein-containing, selectively permeable membrane that surrounds the cytoplasm in prokaryotic and eukaryotic cells.
An enzyme that catalyzes the active transport system of sodium and potassium ions across the cell wall. Sodium and potassium ions are closely coupled with membrane ATPase which undergoes phosphorylation and dephosphorylation, thereby providing energy for transport of these ions against concentration gradients.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
A family of heterotrimeric GTP-binding protein alpha subunits that activate TYPE C PHOSPHOLIPASES dependent signaling pathways. The Gq-G11 part of the name is also spelled Gq/G11.
Serum proteins that have the most rapid migration during ELECTROPHORESIS. This subgroup of globulins is divided into faster and slower alpha(1)- and alpha(2)-globulins.
Differentiation antigens residing on mammalian leukocytes. CD stands for cluster of differentiation, which refers to groups of monoclonal antibodies that show similar reactivity with certain subpopulations of antigens of a particular lineage or differentiation stage. The subpopulations of antigens are also known by the same CD designation.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
The GTPase-containing subunits of heterotrimeric GTP-binding proteins. When dissociated from the heterotrimeric complex these subunits interact with a variety of second messenger systems. Hydrolysis of GTP by the inherent GTPase activity of the subunit causes it to revert to its inactive (heterotrimeric) form. The GTP-Binding protein alpha subunits are grouped into families according to the type of action they have on second messenger systems.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
Collagen receptors are cell surface receptors that modulate signal transduction between cells and the EXTRACELLULAR MATRIX. They are found in many cell types and are involved in the maintenance and regulation of cell shape and behavior, including PLATELET ACTIVATION and aggregation, through many different signaling pathways and differences in their affinities for collagen isoforms. Collagen receptors include discoidin domain receptors, INTEGRINS, and glycoprotein VI.
A PERTUSSIS TOXIN-sensitive GTP-binding protein alpha subunit. It couples with a variety of CELL SURFACE RECEPTORS, has been implicated in INTERLEUKIN-12 production, and may play a role in INFLAMMATORY BOWEL DISEASES.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
CELL LINE derived from the ovary of the Chinese hamster, Cricetulus griseus (CRICETULUS). The species is a favorite for cytogenetic studies because of its small chromosome number. The cell line has provided model systems for the study of genetic alterations in cultured mammalian cells.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
Precursor of epinephrine that is secreted by the adrenal medulla and is a widespread central and autonomic neurotransmitter. Norepinephrine is the principal transmitter of most postganglionic sympathetic fibers and of the diffuse projection system in the brain arising from the locus ceruleus. It is also found in plants and is used pharmacologically as a sympathomimetic.
Proteins found in the nucleus of a cell. Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
A benzodioxane-linked imidazole that has alpha-2 adrenoceptor antagonist activity.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.
An alpha-1 adrenergic agonist used as a mydriatic, nasal decongestant, and cardiotonic agent.
A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.
Eukaryotic initiation factor of protein synthesis. In higher eukaryotes the factor consists of three subunits: alpha, beta, and gamma. As initiation proceeds, eIF-2 forms a ternary complex with Met-tRNAi and GTP.
Quantitative determination of receptor (binding) proteins in body fluids or tissue using radioactively labeled binding reagents (e.g., antibodies, intracellular receptors, plasma binders).
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
CELL LINES derived from the CV-1 cell line by transformation with a replication origin defective mutant of SV40 VIRUS, which codes for wild type large T antigen (ANTIGENS, POLYOMAVIRUS TRANSFORMING). They are used for transfection and cloning. (The CV-1 cell line was derived from the kidney of an adult male African green monkey (CERCOPITHECUS AETHIOPS).)
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
An integrin that binds to a variety of plasma and extracellular matrix proteins containing the conserved RGD amino acid sequence and modulates cell adhesion. Integrin alphavbeta3 is highly expressed in OSTEOCLASTS where it may play role in BONE RESORPTION. It is also abundant in vascular smooth muscle and endothelial cells, and in some tumor cells, where it is involved in angiogenesis and cell migration. Although often referred to as the vitronectin receptor there is more than one receptor for vitronectin (RECEPTORS, VITRONECTIN).
Established cell cultures that have the potential to propagate indefinitely.
The sum of the weight of all the atoms in a molecule.
Processes that stimulate the GENETIC TRANSCRIPTION of a gene or set of genes.
A basic helix-loop-helix transcription factor that plays a role in APOPTOSIS. It is composed of two subunits: ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR and HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A basic element found in nearly all organized tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
A stable prostaglandin endoperoxide analog which serves as a thromboxane mimetic. Its actions include mimicking the hydro-osmotic effect of VASOPRESSIN and activation of TYPE C PHOSPHOLIPASES. (From J Pharmacol Exp Ther 1983;224(1): 108-117; Biochem J 1984;222(1):103-110)
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
A characteristic feature of enzyme activity in relation to the kind of substrate on which the enzyme or catalytic molecule reacts.
The arrangement of two or more amino acid or base sequences from an organism or organisms in such a way as to align areas of the sequences sharing common properties. The degree of relatedness or homology between the sequences is predicted computationally or statistically based on weights assigned to the elements aligned between the sequences. This in turn can serve as a potential indicator of the genetic relatedness between the organisms.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
Positively charged particles composed of two protons and two NEUTRONS, i.e. equivalent to HELIUM nuclei, which are emitted during disintegration of heavy ISOTOPES. Alpha rays have very strong ionizing power, but weak penetrability.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Transport proteins that carry specific substances in the blood or across cell membranes.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.
A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.
The first continuously cultured human malignant CELL LINE, derived from the cervical carcinoma of Henrietta Lacks. These cells are used for VIRUS CULTIVATION and antitumor drug screening assays.
A group of enzymes with the general formula CMP-N-acetylneuraminate:acceptor N-acetylneuraminyl transferase. They catalyze the transfer of N-acetylneuraminic acid from CMP-N-acetylneuraminic acid to an acceptor, which is usually the terminal sugar residue of an oligosaccharide, a glycoprotein, or a glycolipid. EC 2.4.99.-.
A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.
Neurotoxic proteins from the venom of the banded or Formosan krait (Bungarus multicinctus, an elapid snake). alpha-Bungarotoxin blocks nicotinic acetylcholine receptors and has been used to isolate and study them; beta- and gamma-bungarotoxins act presynaptically causing acetylcholine release and depletion. Both alpha and beta forms have been characterized, the alpha being similar to the large, long or Type II neurotoxins from other elapid venoms.
The commonest and widest ranging species of the clawed "frog" (Xenopus) in Africa. This species is used extensively in research. There is now a significant population in California derived from escaped laboratory animals.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
Carbohydrates consisting of between two (DISACCHARIDES) and ten MONOSACCHARIDES connected by either an alpha- or beta-glycosidic link. They are found throughout nature in both the free and bound form.
Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.
The process by which two molecules of the same chemical composition form a condensation product or polymer.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
Within a eukaryotic cell, a membrane-limited body which contains chromosomes and one or more nucleoli (CELL NUCLEOLUS). The nuclear membrane consists of a double unit-type membrane which is perforated by a number of pores; the outermost membrane is continuous with the ENDOPLASMIC RETICULUM. A cell may contain more than one nucleus. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
A ubiquitously expressed family of heterotrimeric GTP-binding protein alpha subunits that signal through interactions with a variety of second messengers as GTPASE-ACTIVATING PROTEINS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; and HEAT SHOCK PROTEINS. The G12-G13 part of the name is also spelled G12/G13.
Female germ cells derived from OOGONIA and termed OOCYTES when they enter MEIOSIS. The primary oocytes begin meiosis but are arrested at the diplotene state until OVULATION at PUBERTY to give rise to haploid secondary oocytes or ova (OVUM).
Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.
A C19 norditerpenoid alkaloid (DITERPENES) from the root of ACONITUM plants. It activates VOLTAGE-GATED SODIUM CHANNELS. It has been used to induce ARRHYTHMIAS in experimental animals and it has antiinflammatory and antineuralgic properties.
Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
The characteristic 3-dimensional shape of a carbohydrate.
DNA sequences encoding the alpha chain of the T-cell receptor. The genomic organization of the TcR alpha genes is essentially the same in all species and is similar to the organization of Ig genes.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
Cholestanes substituted in any position with one or more hydroxy groups. They are found in feces and bile. In contrast to bile acids and salts, they are not reabsorbed.
An serine-threonine protein kinase that requires the presence of physiological concentrations of CALCIUM and membrane PHOSPHOLIPIDS. The additional presence of DIACYLGLYCEROLS markedly increases its sensitivity to both calcium and phospholipids. The sensitivity of the enzyme can also be increased by PHORBOL ESTERS and it is believed that protein kinase C is the receptor protein of tumor-promoting phorbol esters.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A family of DNA-binding transcription factors that contain a basic HELIX-LOOP-HELIX MOTIF.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The biosynthesis of PEPTIDES and PROTEINS on RIBOSOMES, directed by MESSENGER RNA, via TRANSFER RNA that is charged with standard proteinogenic AMINO ACIDS.
Spectroscopic method of measuring the magnetic moment of elementary particles such as atomic nuclei, protons or electrons. It is employed in clinical applications such as NMR Tomography (MAGNETIC RESONANCE IMAGING).
Any of various enzymatically catalyzed post-translational modifications of PEPTIDES or PROTEINS in the cell of origin. These modifications include carboxylation; HYDROXYLATION; ACETYLATION; PHOSPHORYLATION; METHYLATION; GLYCOSYLATION; ubiquitination; oxidation; proteolysis; and crosslinking and result in changes in molecular weight and electrophoretic motility.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in enzyme synthesis.
A family of DNA binding proteins that regulate expression of a variety of GENES during CELL DIFFERENTIATION and APOPTOSIS. Family members contain a highly conserved carboxy-terminal basic HELIX-TURN-HELIX MOTIF involved in dimerization and sequence-specific DNA binding.
A class of saturated compounds consisting of two rings only, having two or more atoms in common, containing at least one hetero atom, and that take the name of an open chain hydrocarbon containing the same total number of atoms. (From Riguady et al., Nomenclature of Organic Chemistry, 1979, p31)
An alpha integrin with a molecular weight of 160-kDa that is found in a variety of cell types. It undergoes posttranslational cleavage into a heavy and a light chain that are connected by disulfide bonds. Integrin alphaV can combine with several different beta subunits to form heterodimers that generally bind to RGD sequence-containing extracellular matrix proteins.
An interleukin receptor subunit with specificity for INTERLEUKIN-13. It dimerizes with the INTERLEUKIN-4 RECEPTOR ALPHA SUBUNIT to form the TYPE II INTERLEUKIN-4 RECEPTOR which has specificity for both INTERLEUKIN-4 and INTERLEUKIN-13. Signaling of this receptor subunit occurs through the interaction of its cytoplasmic domain with JANUS KINASES such as the TYK2 KINASE.
A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.
T-cell receptors composed of CD3-associated alpha and beta polypeptide chains and expressed primarily in CD4+ or CD8+ T-cells. Unlike immunoglobulins, the alpha-beta T-cell receptors recognize antigens only when presented in association with major histocompatibility (MHC) molecules.
A dsRNA-activated cAMP-independent protein serine/threonine kinase that is induced by interferon. In the presence of dsRNA and ATP, the kinase autophosphorylates on several serine and threonine residues. The phosphorylated enzyme catalyzes the phosphorylation of the alpha subunit of EUKARYOTIC INITIATION FACTOR-2, leading to the inhibition of protein synthesis.
A category of nucleic acid sequences that function as units of heredity and which code for the basic instructions for the development, reproduction, and maintenance of organisms.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
... alpha * p; r = r - alpha * Ap; rsnew = r' * r; if sqrt(rsnew) , 1e-10 break end p = r + (rsnew / rsold) * p; rsold = rsnew; end ... displaystyle \alpha _{k}}. f. (. x. k. +. 1. ). =. f. (. x. k. +. α. k. p. k. ). =:. g. (. α. k. ). g. ′. (. α. k. ). =. !. 0. ... function x = conjgrad(A, b, x) r = b - A * x; p = r; rsold = r' * r; for i = 1:length(b) Ap = A * p; alpha = rsold / (p' * Ap); ... displaystyle {\begin{aligned}f(\mathbf {x} _{k+1})&=f(\mathbf {x} _{k}+\alpha _{k}\mathbf {p} _{k})=:g(\alpha _{k})\\g'(\alpha ...
Alpha-halogenation[edit]. This reactivity is similar to the tendency of ethers with alpha hydrogen atoms to form peroxides. ... Reaction with chlorine produces alpha-chloroethers. Synthesis[edit]. Ethers can be prepared in the laboratory in several ... Oxygen is more electronegative than carbon, thus the hydrogens alpha to ethers are more acidic than in simple hydrocarbons. ... They are far less acidic than hydrogens alpha to carbonyl groups (such as in ketones or aldehydes), however. ...
Alpha Cygni variables[edit]. Main article: Alpha Cygni variable. Alpha Cygni (α Cyg) variables are nonradially pulsating ... Main article: Alpha-2 Canum Venaticorum variable. Alpha-2 Canum Venaticorum (α2 CVn) variables are main-sequence stars of ...
Alpha equivalence[edit]. A basic form of equivalence, definable on lambda terms, is alpha equivalence. It captures the ... are not alpha-equivalent, because they are not bound in an abstraction. In many presentations, it is usual to identify alpha- ... are alpha-equivalent lambda terms, and they both represent the same function (the identity function). The terms x. {\ ... In general, failure to meet the freshness condition can be remedied by alpha-renaming with a suitable fresh variable. For ...
There are two basic types of transmembrane proteins:[3] alpha-helical and beta-barrels. Alpha-helical proteins are present in ... Alpha-helical channels including ion channels[edit]. *Voltage-gated ion channel like, including potassium channels KcsA and ... Proteins with alpha-helical transmembrane anchors[edit]. *T cell receptor transmembrane dimerization domain ] ... In humans, 27% of all proteins have been estimated to be alpha-helical membrane proteins.[5] Beta-barrel proteins are so far ...
Tuck SF, Patel H, Safi E, Robinson CH (June 1991). "Lanosterol 14 alpha-demethylase (P45014DM): effects of P45014DM inhibitors ... alpha helix and the β4 loop.[8][9] Finally, the active site contains a heme prosthetic group in which the iron is tethered to a ... "Mutations in the CYP51 gene correlated with changes in sensitivity to sterol 14 alpha-demethylation inhibitors in field ... Retrieved from "" ...
Alpha configuration operation[edit]. An alpha Stirling contains two power pistons in separate cylinders, one hot and one cold. ... The alpha configuration has two power pistons, one in a hot cylinder, one in a cold cylinder, and the gas is driven between the ... Unlike the alpha type, the beta type avoids the technical problems of hot moving seals, as the power piston is not in contact ... The complete alpha type Stirling cycle. Note that if the application of heat and cold is reversed, the engine runs in the ...
Alpha A. α. {\displaystyle \mathrm {A} \,\alpha }. Α α Digamma Ϝ. ϝ. {\displaystyle \mathrm {\Digamma} \,\digamma }. Ϝ ϝ Kappa ... Αα (alpha)[edit]. See also: Alpha (disambiguation). *. α. {\displaystyle \alpha }. represents: *the first angle in a triangle, ...
Not to be confused with Alpha diversity.. The term "alpha taxonomy" is primarily used today to refer to the discipline of ... William Bertram Turrill introduced the term "alpha taxonomy" in a series of papers published in 1935 and 1937 in which he ... Turrill thus explicitly excludes from alpha taxonomy various areas of study that he includes within taxonomy as a whole, such ... He further excludes phylogenetic reconstruction from alpha taxonomy (pp. 365-366). Later authors have used the term in a ...
There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene is an alpha ... Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the ... Tubulin alpha-3C/D chain is a protein that in humans is encoded by the TUBA3C gene.[3][4] ... "Entrez Gene: TUBA3C tubulin, alpha 3c".. *^ Klein C, Kramer EM, Cardine AM, Schraven B, Brandt R, Trotter J (Feb 2002). " ...
Lyman-alpha forest[edit]. Main article: Lyman-alpha forest. In astronomical spectroscopy, the Lyman-alpha forest is the sum of ... Lyman-alpha forest observations can also constrain cosmological models.[79] These constraints agree with those obtained from ... In 2013 results from the Alpha Magnetic Spectrometer on the International Space Station indicated excess high-energy cosmic ... AMS Collaboration) (3 April 2013). "First Result from the Alpha Magnetic Spectrometer on the International Space Station: ...
displaystyle \alpha }. : L. (. α. ). =. D. −. α. L. D. −. α. {\displaystyle L^{(\alpha )}=D^{-\alpha }LD^{-\alpha }}. ... displaystyle L^{(\alpha )}=D^{-\alpha }LD^{-\alpha }\,}. where D is a diagonal matrix and D. i. ,. i. =. ∑. j. L. i. ,. j. .. ... displaystyle M=({D}^{(\alpha )})^{-1}L^{(\alpha )},\,}. where D. (. α. ). {\displaystyle D^{(\alpha )}}. is a diagonal matrix ... displaystyle {D}_{i,i}^{(\alpha )}=\sum _{j}L_{i,j}^{(\alpha )}.}. p. (. x. j. ,. t. ,. x. i. ). =. M. i. ,. j. t. {\ ...
Retrieved from ",_type_XX,_alpha_1&oldid=705418915" ...
Effects may take longer to appear than alpha blockers, but they persist for many years.[54] When used together with alpha ... As men age, the enzymes aromatase and 5-alpha reductase increase in activity. Aromatase and 5-alpha reductase are responsible ... Alpha blockers[edit]. Selective α1-blockers are the most common choice for initial therapy.[43][44][45] They include alfuzosin, ... Alpha blockers such as terazosin, 5α-reductase inhibitors such as finasteride[1]. ...
... the soluble fraction of alpha-amylase hydrolyzed oat bran or whole oat flour), whole grain barley and barley beta-fiber. An ...
Alpha. Νν. Nu. Ββ. Beta. Ξξ. Xi. Γγ. Gamma. Οο. Omicron. Δδ. Delta. Ππ. Pi. ...
displaystyle ,\alpha ,\leq q^{d/2}}. Poincaré duality then implies that ,. α. ,. =. q. d. /. 2. .. {\displaystyle ,\alpha ,=q^{ ... displaystyle ,\alpha ,\leq q^{(d-1)/2}.}. Poincaré duality then implies that ,. α. ,. =. q. (. d. −. 1. ). /. 2. .. {\ ... displaystyle ,\alpha ^{k},\leq q^{k(d-1)/2+1}}. As this is true for arbitrarily large even k, this implies that ,. α. ,. ≤. q. ... displaystyle ,\alpha ^{k},\leq q^{kd/2+1/2}}. As this is true for arbitrarily large even k, this implies that ,. α. ,. ≤. q. d ...
Alpha. At the end of the first day on the station, Shepherd requested the use of the radio call sign "Alpha", which he and ... "Alpha"; he felt that Mir was the first space station, and so he would have preferred the names "Beta" or "Mir 2" for the ISS.[ ... Krikalev preferred it to the more cumbersome "International Space Station".[5] The name "Alpha" had previously been used for ... "Space Station Alpha Crew Settles Into Daily Routine". Archived from the original on 29 April 2010. Retrieved 10 ...
Alpha. .mw-parser-output .nobold{font-weight:normal}. HSV. *Herpes simplex. *Herpetic whitlow ...
... alpha activity in the temporal or frontal lobes).[82][83] Alpha can be abnormal; for example, an EEG that has diffuse alpha ... Alpha is the frequency range from 7 Hz to 13 Hz.[81] Hans Berger named the first rhythmic EEG activity he observed the "alpha ... In addition to the posterior basic rhythm, there are other normal alpha rhythms such as the mu rhythm (alpha activity in the ... Alpha 8-15. posterior regions of head, both sides, higher in amplitude on dominant side. Central sites (c3-c4) at rest. * ...
"Risk of herpes zoster in patients with rheumatoid arthritis treated with anti-TNF-alpha agents". JAMA. 301 (7): 737-44. doi: ...
displaystyle f_{c}={\frac {\alpha }{(1-\alpha )2\pi \Delta _{T}}}}. .. If α. =. 0.5. {\displaystyle \alpha \;=\;0.5}. , then ... displaystyle \alpha }. and f. c. {\displaystyle f_{c}}. are related by: α. =. 2. π. Δ. T. f. c. 2. π. Δ. T. f. c. +. 1. {\ ... displaystyle \scriptstyle \alpha }. : R. C. =. Δ. T. (. 1. −. α. α. ). {\displaystyle RC=\Delta _{T}\left({\frac {1-\alpha }{\ ... displaystyle y_{i}=\alpha x_{i}+(1-\alpha )y_{i-1}\qquad {\text{where}}\qquad \alpha :={\frac {\Delta _{T}}{RC+\Delta _{T}}}}. ...
Interferon alpha (interferon alfa, IFN-α). *Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, ... CD8-positive, alpha-beta T cell differentiation involved in immune response. • neutrophil apoptotic process. • sensory ... positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response. • ...
... "alpha" may be appended to the version number. So the alpha version of the 2.5 release might be identified as 2.5a or 2.5.a. ... For example, Minecraft Alpha ran from version 1.0.0 to 1.2.6, and when Beta was released, it reset the major version number, ... Software in the experimental stage (alpha or beta) often use a zero in the first ("major") position of the sequence to ... Programs that are in an early stage are often called "alpha" software, after the first letter in the Greek alphabet. After they ...
Alpha. Νν. Nu. Ββ. Beta. Ξξ. Xi. Γγ. Gamma. Οο. Omicron. Δδ. Delta. Ππ. Pi. ...
... alpha _{1}+\cdots +\alpha _{n},\quad \alpha !=\alpha _{1}!\cdots \alpha _{n}!,\quad {\boldsymbol {x}}^{\alpha }=x_{1}^{\alpha ... alpha }+\sum _{,\alpha ,=k+1}{\frac {k+1}{\alpha !}}(\mathbf {x} -\mathbf {a} )^{\alpha }\int _{0}^{1}(1-t)^{k}(D^{\alpha }f)(\ ... alpha }f({\boldsymbol {a}})}{\alpha !}}({\boldsymbol {x}}-{\boldsymbol {a}})^{\alpha }+\sum _{,\alpha ,=k}h_{\alpha }({\ ... displaystyle D^{\alpha }f={\frac {\partial ^{,\alpha ,}f}{\partial x_{1}^{\alpha _{1}}\cdots \partial x_{n}^{\alpha _{n}}}},\ ...
Interferon alpha (interferon alfa, IFN-α). *Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, ...
Within the United States and as delineated in the National Response Plan, disaster response and planning is first and foremost a local government responsibility. When local government exhausts its resources, it then requests specific additional resources from the county level. The request process proceeds similarly from the county to the state to the federal government as additional resource needs are identified. Many of the problems that arose developed from inadequate planning and back-up communication systems at various levels.[118] Some disaster recovery response to Katrina began before the storm, with the Federal Emergency Management Agency (FEMA) preparations that ranged from logistical supply deployments to a mortuary team with refrigerated trucks. A network of volunteers began rendering assistance to local residents and residents emerging from New Orleans and surrounding parishes as soon as the storm made landfall (even though many were directed to not enter the area), and continued for ...
Secker & Warburg was formed in 1935 from a takeover of Martin Secker, which was in receivership, by Fredric Warburg and Roger Senhouse. The firm became renowned for its political stance, being both anti-fascist and anti-communist, a position that put them at loggerheads with the ethos of many intellectuals of the time.[citation needed] When George Orwell parted company with Communist Party sympathizer Victor Gollancz over his editing of The Road to Wigan Pier (1937), he took his next book Homage to Catalonia to Secker & Warburg, who published it in 1938. They also published, after 18 months of rejections and setbacks, Animal Farm (1945), and Orwell's subsequent books.[1] Orwell and Warburg later became intimate friends. Secker & Warburg published other books by key figures of the anti-Stalinist left, such as Minty Alley, World Revolution, and The Black Jacobins by C. L. R. James,[2] Rudolf Rocker and Boris Souvarine,[3] as well as works by Lewis Mumford. In February 1941 the company launched a ...
Their eighth studio album Alpha was released on December 8, 2017.. Contents. ...
L-Alpha glycerylphosphorylcholine (alpha-GPC, choline alfoscerate) is a natural choline compound found in the brain. It is also ... Many users report degradation of alpha-GPC when stored openly or for long periods of time. Alpha-GPC is hygroscopic and will ... a b US Food and Drug Administration: Generally Recognized as Safe (GRAS) Determination for the Use of AlphaSize Alpha- ... For people accessing alpha-GPC daily it is advisable to separate a months supply from excess and storing the excess as best as ...
Human TNF-alpha ELISpot Development Module, 5 Plate (SEL210) * Human TNF-alpha HS Magnetic Luminex Performance Assay (LHSCM210) ... RayBiotech Human TNF-alpha ELISA and Human TNF-alpha ELISA (For Lysates) ... G Biosciences Immunotag™ Human TNFa (Tumor Necrosis Factor Alpha) ELISA and Immunotag™ Tumor necrosis factor ELISA Kit ... tumor necrosis factor,alpha (cachectin),potent proinflammatory cytokine,involved in inflammatory and immune responses, ...
ALPHA Service Desk Hours. Monday 10:00am-1:00am. Tuesday 10:00am-1:00am ... ALPHA is Santa Clara Universitys longest-running Residential Learning Community and was the first RLC to bring students in a ... We consider what it means to be human, and our activities and discussions reflect this. In ALPHA, we love our community and ... Website Currently Under Renovation The ALPHA RLC is currently updating our website! Sorry for any inconveniences, we will be ...
Therefore, Alpha turned more and more to the commercial sale of its products. Alpha Industries is now a manufacturer of ... This budding public knowledge of Alphas products created the first true demand for Alpha apparel in the public market. A ... This meant another boom for manufacturers like Alpha. Because DOD contracts were given preferably to small companies, Alpha did ... Childrens clothing and accessories are also made by Alpha Industries. Alpha has expanded into networks of international ...
... is a blood disorder in which the body has a problem producing alpha globin, a component of hemoglobin, the ... About Alpha Thalassemia. Normally, each person has four genes for alpha globin. Alpha thalassemia happens when one or more of ... Alpha globin is made by four genes and one or more can be mutated or missing, so there are four kinds of alpha thalassemia:. * ... Alpha thalassemia: when the body has a problem producing alpha globin. *Beta thalassemia: when the body has a problem producing ...
... in Real Terms Want to dominate the Market?? Then let us understand the real concept of Alpha Leadership which ... Alpha Leadership. May 13, 2019, 11:15 AM IST Vaibhav Datar in THE-MAVEN-STYLE, Lifestyle, TOI ... The term "alpha," coined the first letter of the Greek alphabet, means "something that is prior," First" or "the beginning." In ... Body Language of an Alpha leader at work: Body Language is the best trick to make you the most effective leader. *Think before ...
What is alpha-gal syndrome (AGS)?. Alpha-gal syndrome (AGS) (also called alpha-gal allergy, red meat allergy, or tick bite meat ... What is alpha-gal?. *Alpha-gal (galactose-α-1,3-galactose) is a sugar molecule found in most mammals. ... Alpha-gal can be found in products made from mammals (including some medications, cosmetics, vaccines, gelatin, and milk ... Symptoms commonly appear 3-6 hours after eating meat or exposure to products containing alpha-gal (for example, gelatin-coated ...
... The almost universally used English International Phonetic Alphabet was adopted in 1955 for use by ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Alpha & Beta is a 2d platform game for those who love old platform games but with a few touches on this old style, the most ... Buy Alpha & Beta + Choose Difficulty DLC Includes 2 items: Alpha & Beta, Alpha & Beta: Choose Difficulty ... Alpha and Beta are two brothers, but because of Alphas greed and efficacy, the two brothers became hostile to each other and ... Alpha & Beta is a 2d platform game for those who love old platform games but with a few touches on this old style, the most ...
Wolfram,Alpha has broad knowledge and deep computational power when it comes to math. Whether it be arithmetic, algebra, ... Enable Javascript to interact with content and submit forms on Wolfram,Alpha websites. Learn How » ... calculus, differential equations or anything in between, Wolfram,Alpha is up to the challenge. Get help with math homework, ...
Use Wolfram,Alpha to explore cheminformatics properties, from graph invariants like Balabans J-index or the Hosoya index to ... Enable Javascript to interact with content and submit forms on Wolfram,Alpha websites. Learn How » ...
Brand identity proposal for an independent mens fashion boutique in East London. The identity suite consists of logo, styleguide, signage and in-store graphics.
Human alpha-1a/d adrenergic receptor mRNA, complete cds. P. S70782.1. Homo sapiens alpha adrenergic receptor subtype alpha 1a ... Homo sapiens adrenoceptor alpha 1D (ADRA1D), mRNA. P. U03864.1. Human adrenergic alpha-1a receptor protein mRNA, complete cds. ... alpha-1D adrenergic receptor. M. musculus. 88.1. 561. XP_697043.2 * Conserved domains (CDD) * * Gene summary * * Protein ... PREDICTED: alpha-1D adrenergic receptor. P. anubis. 98.6. 569. XP_002798256.1 * Conserved domains (CDD) * * Gene summary * * ...
Alpha-mannosidosis is a rare inherited disorder that causes problems in many organs and tissues of the body. Explore symptoms, ... Mutations in the MAN2B1 gene cause alpha-mannosidosis. This gene provides instructions for making the enzyme alpha-mannosidase ... Intracellular transport of human lysosomal alpha-mannosidase and alpha-mannosidosis-related mutants. Biochem J. 2004 Jul 15;381 ... Alpha-mannosidosis. Orphanet J Rare Dis. 2008 Jul 23;3:21. doi: 10.1186/1750-1172-3-21. Review. Citation on PubMed or Free ...
... and learn more about Alpha Ebot. Download Alpha Ebot and enjoy it on your iPhone, iPad, and iPod touch. ... Alpha Ebot is to implement a software to interact with robots, this software using the bluetooth BLE protocol to transmit ...
Chemical Entities of Biological Interest (ChEBI) is a freely available dictionary of molecular entities focused on small chemical compounds.
Techno-economic analyses of specific alpha cyclodextrin production processes, presenting capital investment breakdown, raw ... ECONOMICS OF ALPHA-CYCLODEXTRIN PRODUCTION FROM CORN (ALPHA-CYCLODEXTRIN E12A) It presents the economics of alpha-Cyclodextrin ... Understand Alpha- Cyclodextrin production costs Industrial Process Economics About Alpha-Cyclodextrin Reports Coverage of Alpha ... ALPHA-CYCLODEXTRIN E11A) This report presents the economics of alpha-Cyclodextrin production from corn in the USA, using a ...
bc home , offices , news & public affairs , 2012-sep-oct , Current page: alpha sigma nu book award ... The Alpha Sigma Nu Jesuit Book Awards, established in 1979, recognize outstanding publishing achievement at Jesuit colleges and ... October 2012) - Boston College organic chemist Lawrence T. Scott has been honored by Alpha Sigma Nu, the Jesuit honor society, ... with a 2012 Alpha Sigma Nu Book Award for his co-edited book, Fragments of Fullerenes and Carbon Nanotubes. Scotts publication ...
Alpha is more than a search engine. It gives you access to the worlds facts and data and calculates answers across a range of ... You have the Wolfram CDF Player installed and can now enable Wolfram,Alpha Interactive to:. *Interact with your results using ... Free online access to the Wolfram,Alpha computational knowledge engine:. Answer questions, do math, instantly get facts, create ... We appreciate your interest in Wolfram,Alpha and will be in touch soon. ...
Find 1000s of Alpha Banners banners on CafePress today! We have hundreds of different banner designs; cant find one you like? ... I do alpha male shit, funny, humor, cool, motivati On sale for $47.49, ... Its going to be a banner day! Especially when you display one of these awesome 44 x 30? Alpha Banners. The perfect size for ... "3-D" Golden Alpha and Omega Symbol Banner On sale for $47.49, ... Alpha B Banner On sale for $47.49,. The original price was $ ...
Each year AED hosts an Annual Halloween Food Drive to help the needy families in the Baton Rouge area. The event collects food and on Halloween we deliver our donations to a neighborhood in Baton Rouge, so that those people will have a great Halloween. This is our way to give back to the Baton Rouge community. This year the food drive was will be held on Wednesday, October 31, 2018 in Kenilworth Subdivision. Sign ups are on the service calendar. ...
Alpha-fetoprotein and Congenital Disorders. Issue 14 of Birth Defects Institute symposia. Studies in Urban Economics. ... AChE bands AChE/PChE ratio acid affinity AFP and albumin AFP gene AFP mRNA AFP screening AFP values Alpha-fetoprotein ALPHA- ... prevalence protease protein rat AFP rates receptors reported screening serum AFP concentration serum AFP levels Serum Alpha- ... gb-gplus-shareAlpha-fetoprotein and Congenital Disorders. ... Alpha-fetoprotein and Congenital Disorders. Gerald J. ...
an Alpha can be dual booted without ``time warps.. The kernel on the installation CDs is now separated from the mfsroot. ... FreeBSD/alpha 4.5-RELEASE Release Notes. The FreeBSD Project. Copyright © 2000, 2001, 2002 by The FreeBSD Documentation Project ... In order to allow dual booting of an Alpha machine without clobbering the TOY clock setting, FreeBSD now supports a boot ... The machine dependent code has been corrected to allow FreeBSD to run on Alphaserver 2100 and 2100A machines based on EV5 Alpha ...
Asus ROG Zenith Extreme Alpha Review: an X399 Thoroughbred. By Jacob Terkelsen 05 August 2019. ... NVMe performance is a strong showing for the Alpha as well, and note this data is not from the DIMM.2 riser but from the ... The Asus Zenith Extreme Alpha is a thoroughbred when compared to our other offerings today but shows middle-of-the-pack ... Overall performance shows nearly perfect marks for the Asus X399 Zenith Extreme Alpha, but it slips up in applications by a ...
See an archive of all cut/alpha shoes stories published on the New York Media network, which includes NYMag, The Cut, Vulture, ... Were sorry, but we didnt find any results for "Cut/alpha Shoes ". Please try again or browse Nymags main page.. ...
... in alpha or in beta. Alpha usually denotes a developer release only. Software moves out of alpha into beta stage when it ... In statistics the alpha level is the probability that you will wrongly reject the null hypothesis. This is also referred to as ... What is Alpha Beta Alphas motto?. Alpha Beta Alphas motto is Books, People, Service, Life. ... Mass of alpha beta gamma?. Well mass of alpha is 4 but i dont know the other two, sorry The mass for alpha beta and gamma are ...
... or alpha-alanine (α-alanine), is a constituent of proteins. An especially rich source of L-alanine is silk fibroin, from which ... Other articles where Alpha alanine is discussed: alanine: …one of which, L-alanine, ... one of which, L-alanine, or alpha-alanine (α-alanine), is a constituent of proteins. An especially rich source of L-alanine is ...
1.6.6. What about support for NT Alpha binaries?. 1.6.1. Can I boot from the ARC or Alpha BIOS Console? ... 1.6 Question and Answer Section for Alpha/AXP Architecture Users. 1.6.1. Can I boot from the ARC or Alpha BIOS Console?. 1.6.2 ... To make FreeBSD/alpha boot automatically, use these commands:. ,,,. set boot_osflags a. ,,,. set bootdef_dev dkc0. ,,,. set ... You will need a dedicated disk for FreeBSD/alpha. It is not possible to share a disk with another operating system at this time ...
Functional activity of alpha-tocopherol. The function of alpha tocopherol is as a fat-soluble antioxidant, which breaks the ... Alpha-tocopherol esters in supplements are chiefly succinate and acetate, and these are converted to alpha-tocopherol in the ... This action of alpha-tocopherol is essential to the protection of the lipid bilayer of all cell membranes, as well as enzymes ... Natural and synthetic alpha tocopherol are different in their composition. The natural form is made up of a molecule with ...
  • A. " Identification and nanomechanical characterization of the fundamental single-strand protofilaments of amyloid {alpha}-synuclein fibrils ," by Francesco Simone Ruggeri, Fabrizio Benedetti, Tuomas P. J. Knowles, Hilal A. Lashuel, Sergey Sekatskii, and Giovanni Dietler (Vol. 115 No. 28, July 10, 2018, p. 7230-7235). (
  • No medications are needed for silent carriers or individuals with alpha thalassemia trait. (
  • [ 10 ] Individuals with beta thalassemia syndromes have somewhat better protection against malaria than individuals with alpha thalassemia syndromes. (
  • Microsoft's Bing is stepping up its assault on Google with bevy of new features available Wednesday that include the addition of Wolfram Alpha search results , enhanced previews of Web sites within results, improved presentation of weather forecasts, and limited Facebook integration. (
  • 5-Alpha-reductase deficiency ( 5-ARD ) is an autosomal recessive intersex condition caused by a mutation of the 5-alpha reductase type 2 gene . (
  • 5-Alpha-reductase deficiency-2 is biochemically characterized by low to low-normal levels of testosterone and decreased levels of 5α-DHT, creating a higher testosterone/DHT ratio. (
  • The form used in the human body is alpha tocopherol, and this form is necessary to treat vitamin E deficiency. (
  • Alpha-1 antitrypsin deficiency is an inherited disease, which means it's passed down to you by your parents. (
  • WHEREAS , Alpha-1 Antitrypsin Deficiency (Alpha-1) is one of the most common serious hereditary disorders in the world and can result in life-threatening liver disease in children and adults or lung disease in adults. (
  • Alpha-1 proteinase inhibitor (Prolastin-C) is a prescription medicine used to treat alpha-1 antitrypsin (AAT) deficiency. (
  • There is no cure for AAT deficiency but alpha-1 proteinase inhibitor can help patients manage their condition. (
  • So, if any gene that tells chromosome 16 to produce alpha globin is missing or mutated, less alpha globin is made. (
  • One missing or abnormal gene makes a child a silent alpha thalassemia carrier . (
  • Mutations in the MAN2B1 gene cause alpha-mannosidosis. (
  • This gene provides instructions for making the enzyme alpha-mannosidase. (
  • Mutations in the MAN2B1 gene interfere with the ability of the alpha-mannosidase enzyme to perform its role in breaking down mannose-containing oligosaccharides. (
  • You won't get alpha-1 yourself, but you pass the gene on to your children. (
  • Rapid detection of alpha-thalassaemia deletions and alpha-globin gene triplication by multiplex polymerase chain reactions. (
  • Interferon alpha-1/13 is a protein that in humans is encoded by the IFNA1 gene . (
  • Bing has partnered with Wolfram Alpha, the computational knowledge engine, to help you make better choices for your health and your waistline. (
  • Some children with alpha thalassemia have no symptoms and require no treatment. (
  • Silent alpha thalassemia carriers have no signs or symptoms of the disease, but are able to pass thalassemia on to their children. (
  • People with alpha thalassemia minor usually don't have any symptoms at all, but can pass thalassemia on to their children. (
  • Symptoms commonly appear 3-6 hours after eating meat or exposure to products containing alpha-gal (for example, gelatin-coated medications). (
  • The signs and symptoms of alpha-mannosidosis can range from mild to severe. (
  • Other individuals with alpha-mannosidosis experience milder signs and symptoms that appear later and progress more slowly. (
  • In addition to high blood pressure, doctors prescribe alpha blockers to prevent, treat or improve symptoms of an enlarged prostate (benign prostatic hyperplasia). (
  • Most of the symptoms from alpha-1 are due to the effects in the lungs. (
  • What are the symptoms of alpha thalassemia? (
  • Different people will have different symptoms, based on which type of alpha thalassemia is inherited. (
  • People with alpha thalassemia may have no symptoms. (
  • Many people who acquire an alpha-gal allergy have no history of other allergies or allergic symptoms. (
  • Normally, each person has four genes for alpha globin. (
  • Alpha thalassemia happens when one or more of the genes that control the making of alpha globins is absent or defective. (
  • Two missing or mutated genes is a condition called alpha thalassemia minor or having alpha thalassemia trait . (
  • Four missing or mutated genes is a condition known as alpha thalassemia major or hydrops fetalis . (
  • Lab workers will check your sample for the faulty genes that cause alpha-1. (
  • Alpha thalassemia occurs when some or all of the 4 genes that make hemoglobin (the alpha-globin genes) are missing or damaged. (
  • Alpha thalassemia occurs when one or more of the 4 alpha-globin genes that make up part of the hemoglobin molecule are missing or damaged. (
  • This test identifies which alpha globin genes are present, absent, or damaged. (
  • Alpha-thalassemia: Hb H disease and Hb Barts hydrops fetalis. (
  • (
  • Buildd statistics at and are also heading the wrong way, and a recent thread on debian-alpha shows that eglibc 2.10 currently fails its testsuite. (
  • Dictionary , Merriam-Webster, (
  • Alpha blockers are also called alpha-adrenergic blocking agents, alpha-adrenergic antagonists, adrenergic blocking agents and alpha-blocking agents. (
  • AGS is diagnosed by an allergist, or other healthcare provider through a detailed patient history, physical examination, and a blood test that looks for specific antibodies to alpha-gal. (
  • The present invention refers to recombinant antibodies of human origin specific for the C5 component of the activated complement and characterised by the ability to inhibit the conversion of the C5 alpha chain to C5a and C5b. (
  • When alpha-gal enters the body, via a tick bite or otherwise, the immune system produces antibodies to fight the molecule. (
  • It remains unclear exactly what substance in the tick's saliva causes the development of alpha-gal antibodies. (
  • To determine if alpha-gal antibodies are present in the body, a blood test may be recommended by a doctor. (
  • There is evidence that the alpha-gal molecule is found in the saliva of certain types of ticks. (
  • G protein alpha transducin was purified from bovine retinal extracts more than three decades ago. (
  • Only this form is bound by the liver transport protein called alpha-tocopherol transport protein, which carries it to the site where it is incorporated into lipoproteins and carried to other parts of the body. (
  • The function of alpha tocopherol is as a fat-soluble antioxidant, which breaks the chain of oxidation reactions which are propagating down a cell membrane or plasma protein by means of newly produced free radicals. (
  • Alpha fetoprotein (AFP) is a protein found in human blood . (
  • Another blood test measures how much of the alpha-1 protein is in your body. (
  • Despite considerable evidence linking alpha-synuclein with membranes in vitro, it has proven difficult to demonstrate membrane association of the protein in vivo. (
  • To address the dynamics of the protein in live cells, we have used photobleaching and found that alpha-synuclein exhibits high mobility, although distinctly less than an entirely soluble protein. (
  • Allergy researcher Thomas Platts-Mills of the University of Virginia started studying the alpha-gal reaction in 2002 after discovering an allergic reaction to the cancer drug cetuximab. (
  • A DNA test is needed to make a diagnosis of alpha thalassemia. (
  • Genetic testing is currently available to establish the diagnosis of alpha thalassemia and clarify the genetic abnormalities in patients with a family history or laboratory results suggestive of an alpha thalassemia syndrome. (
  • The WGSN approved the name Sadalmelik for Alpha Aquarii (WDS J22058-0019 A) on 21 August 2016, and it is now so included in the List of IAU-approved Star Names (Delta Cassiopeiae was given the name Ruchbah). (
  • How many episodes of Alphas have you seen? (
  • It's made up of alpha globin and beta globin. (
  • Alpha globin is made on chromosome 16. (
  • A very tightly controlled globin chain production process keeps the ratio of alpha chains to non-alpha chains at 1.00 (± 0.05). (
  • Wolfram Alpha went public today, and there is a lot to like about it. (
  • I typed "OOXML is a fraud" into Wolfram Alpha. (
  • It looks as if, in its first day of public life, Wolfram Alpha is still a wee bit naiive and has a lot to learn. (
  • After figuring out where you went wrong in your diet, you can use Bing's Wolfram Alpha integration to determine your body mass index. (
  • High doses of alpha tocopherol (2000 IU/day) may cause bleeding manifestations in individuals on anticoagulants by interfering with the vitamin K- mediated coagulation cascade. (
  • Standard Fama-French and Carhart models produce economically and statistically significant nonzero alphas, even for passive benchmark indices such as the S&P 500 and Russell 2000. (
  • However, wealth is not the only alpha male trait that is still in vogue . (
  • For people accessing alpha-GPC daily it is advisable to separate a month's supply from excess and storing the excess as best as possible. (
  • AGS may occur after people eat red meat or are exposed to other products containing alpha-gal. (
  • People may not have an allergic reaction after every alpha-gal exposure. (
  • People with later-onset alpha-mannosidosis may survive into their fifties. (
  • Alpha-mannosidosis is estimated to occur in approximately 1 in 500,000 people worldwide. (
  • One-Alpha drops contain sorbitol and are not suitable for people with rare hereditary problems of fructose intolerance. (
  • Because most people with alpha-1 don't know they have it, many experts recommend alpha-1 testing for everyone with COPD or emphysema. (
  • Flomax may be no more effective than other alpha-blockers, but the manufacturing company spends more than $100 million marketing it to consumers, so it is often the only BPH drug many people know about. (
  • Alphas is a science fiction drama focusing on a team that investigates people with supernatural abilities. (
  • The term alpha-gal is short for galactose-alpha-1, 3-galactose, a carbohydrate molecule that can cause an allergic reaction in people with an alpha-gal allergy. (
  • Most people discover they have an alpha-gal allergy after eating red meat. (
  • So, people with an alpha-gal allergy do not always associate the reaction with what they have eaten. (
  • The immune system of people with an alpha-gal allergy treats the alpha-gal molecule in meat as a physical threat to the body. (
  • The alpha brainwaves are highly dominant in those people who are creative and relaxed and whose mind is clear. (
  • You should therefore, not think of the alpha brain waves as being the cause of all the problems and conditions that people suffer from. (
  • The people who have high levels of alpha brainwaves are children, the meditators and extroverts. (
  • When a child has alpha thalassemia, there is a change in chromosome 16. (
  • L-Alpha glycerylphosphorylcholine ( alpha-GPC , choline alfoscerate ) is a natural choline compound found in the brain. (
  • Alpha-GPC rapidly delivers choline to the brain across the blood-brain barrier and is a biosynthetic precursor of acetylcholine. (
  • It is hypothesized that rising testosterone levels at the start of puberty (around age twelve) are able to generate sufficient levels of DHT either by the action of 5-alpha-reductase type 1 (active in the adult liver, non-genital skin and some brain areas) or through the expression of low levels of 5-alpha-reductase type 2 in the testes. (
  • Through interviews with world-leading neuroscientists, social-media strategists, toy-makers and marketers this new report, from WIRED Consulting and Hotwire, explores the impact of technology on the Alpha Brain. (
  • What do organisations and companies need to do, to adapt to the new alpha brain? (
  • Download the report here and gain insight into the Alpha brain. (
  • One of the most highly recommended ways of increasing the level of alpha brain waves is making use of brainwave entrainment. (
  • Alpha Brain from Onnit Labs is a fully balanced nootropic. (
  • Alpha-gal syndrome (AGS) (also called alpha-gal allergy, red meat allergy, or tick bite meat allergy) is a serious, potentially life-threatening allergic reaction. (
  • Alpha and Beta are two brothers, but because of Alpha's greed and efficacy, the two brothers became hostile to each other and challenged each other to death. (
  • What are alpha and beta? (
  • Software moves out of alpha into beta stage when it is ready for wider 'bug' (error) testing by the average user. (
  • Natural vitamin E includes four tocopherols, called alpha, beta, gamma and delta tocopherol respectively. (
  • Before taking an alpha blocker, be sure your doctor knows about other medications you take, such as beta blockers, calcium channel blockers or medications for erectile dysfunction. (
  • The Alpha Beta chapter at the University of Michigan was founded in 1916 and continues to uphold the traditions of our founding brothers. (
  • There are 2 main types of thalassemia: alpha and beta. (
  • Muncie HL Jr, Campbell J. Alpha and beta thalassemia. (
  • There are 4 major types of globins: alpha (α), beta (β), gamma (γ), and delta (δ). (
  • The dominant hemoglobin in adults (hemoglobin A) is composed of 2 alpha and 2 beta chains. (
  • Gamma radiation is electromagnetic radiation, whereas alpha and beta radiation are forms of particulate radiation. (
  • Gamma comes as a result of alpha or beta. (
  • Gammas covers a bigger area than beta and alpha and is in that way more dangerous, but if you ever get alpha radiation inside of you, that is very dangerous. (
  • Of alpha, beta and gamma radiation, gamma radiation has the greater ability to penetrate either shielding or living tissue. (
  • The penetration issue aside, a contact source that is an alpha emitter can do more tissue damage than beta or gamma radiation. (
  • Alpha and beta radiation are particulate radiation. (
  • 5-Alpha-reductase is an enzyme that converts testosterone to dihydrotestosterone (DHT) in peripheral tissues. (
  • Alpha-1 proteinase inhibitor works in the lower respiratory tract where it inhibits neutrophil elastase (NE), the enzyme that damages lung tissue. (
  • Alpha-gal (galactose-α-1,3-galactose) is a sugar molecule found in most mammals. (
  • In particular, alpha-mannosidase helps break down oligosaccharides containing a sugar molecule called mannose. (
  • Proper storage methods need to be used with alpha-GPC and include removing all air from the container, double bagging with plastic bags rated for chemicals (less likely to leak air), and storing bulk/excess inside the freezer. (
  • Tocopherols are found in almost all plant seeds, the best sources of alpha-tocopherol include plant seeds such as almonds, sunflower seeds and hazelnuts. (
  • If we reach this goal, we will include an extended bestiary of mutant monsters that can be used in both Mutant: Genlab Alpha and Mutant: Year Zero . (
  • Letters that arose from alpha include the Latin A and the Cyrillic letter А. (
  • New research, funded in part by NIEHS, has revealed key insights into how alpha-synuclein aggregates cause damage to neurons in diseases such as Parkinson's disease. (
  • They also studied why microglia migrate toward injured neurons and tend to accumulate with alpha-synuclein aggregates in the affected areas of Parkinson's disease brains, such as the substantia nigra. (
  • The behavior of alpha-synuclein in neurons. (
  • This regulation establishes a tolerance for residues of alpha-cypermethrin in or on food Start Printed Page 73211 commodities/feed commodities in food/feed handling establishments. (
  • Alpha Chi Sigma is a co-ed professional fraternity specializing in the chemical sciences. (
  • Alpha Mu Tau is a national fraternity whose purpose is the advancement of professionals in the clinical laboratory sciences. (
  • All scholarships are administered by the Alpha Mu Tau Fraternity (AMTF). (
  • 1988 ). It serves as the non-signaling alpha-receptor of the multifunctional cytokine IL-6 and is expressed in a cell-type-specific manner. (
  • Prolastin-C is a new formulation of Prolastin, the original alpha-1 proteinase inhibitor that has been available since 1988. (
  • This is the conclusion of the Cullen report into the explosion on the oil rig Piper Alpha that killed 167 men on 6 July 1988. (
  • In English, the noun "alpha" is used as a synonym for "beginning", or "first" (in a series), reflecting its Greek roots. (
  • This document contains the release notes for FreeBSD 4.5-RELEASE on the Alpha/AXP hardware platform. (
  • The machine dependent code has been corrected to allow FreeBSD to run on Alphaserver 2100 and 2100A machines based on EV5 Alpha processors. (
  • This article gives some brief instructions on installing FreeBSD/alpha 5.4-RELEASE, with particular emphasis given to obtaining a FreeBSD distribution. (
  • You will need a dedicated disk for FreeBSD/alpha. (
  • An Italian multicentre clinical trial on 2,044 patients suffering from recent stroke were supplied alpha-GPC in doses of 1,000 mg/day for 28 days and 400 mg three times per day for the five ensuing months. (
  • Tissues and organs are damaged by the abnormal accumulation of oligosaccharides and the resulting cell death, leading to the characteristic features of alpha-mannosidosis. (
  • Alpha blockers are used in combination with other drugs to treat high blood pressure and can treat prostate problems in men. (
  • Alpha blockers lower blood pressure by keeping the hormone norepinephrine from tightening the muscles in the walls of smaller arteries and veins. (
  • Because alpha blockers also relax other muscles throughout the body, these medications also can help improve urine flow in older men with prostate problems. (
  • Alpha blockers are either short-acting or long-acting. (
  • Alpha blockers typically aren't the first treatment option for high blood pressure. (
  • Some alpha blockers might have a "first-dose effect. (
  • Alpha blockers can increase or decrease the effects of other medications you take. (
  • Alpha blockers may improve total cholesterol. (
  • However, some research has found that long-term use of some alpha blockers can increase the risk of heart failure. (
  • Alpha-1 adrenergic blockers. (
  • Flomax is one of a group of drugs called alpha-1 blockers that can help urine flow more easily. (
  • Alternative alpha-blockers are available. (
  • Other alpha-blockers work in much the same way as Flomax. (
  • Both drugs are nonselective alpha-1 blockers, which means they can lower a person's blood pressure. (
  • Selective alpha-blockers, such as Flomax, can also lower blood pressure but not quite as much as nonselective alpha-blockers. (
  • Alpha-blockers are not the only option for treating BPH. (
  • For example, alpha-blockers combined with drugs for an overactive bladder may be more effective. (
  • Gamma-tocopherol is the most common isomer of tocopherol found in the American diet, but its absorption and use appear to be significantly less, and its active excretion and metabolism higher, than for alpha-tocopherol. (
  • Two minor forms of hemoglobin constitute a small percentage of normal blood: hemoglobin F (fetal), composed of 2 alpha chains and 2 gamma chains, and hemoglobin A2, composed of 2 alpha chains and 2 delta chains. (
  • Alpha radiation is a helium nucleus, and gamma radiation is a high energy electromagnetic ray. (
  • Alpha thalassemia combined with sickle-cell anemia results in a higher hemoglobin concentration and improved RBC survival. (
  • The letter alpha represents various concepts in physics and chemistry, including alpha radiation, angular acceleration, alpha particles, alpha carbon and strength of electromagnetic interaction (as Fine-structure constant). (
  • Alpha also stands for thermal expansion coefficient of a compound in physical chemistry. (
  • [ 1 ] As DHT is a far more potent androgen than testosterone alone, virilisation in those lacking DHT may be absent or reduced compared to males with functional 5-alpha reductase. (
  • Studies in some primates have shown that some female reproductive strategies , such as cryptic female mate choice , specifically enable reproduction with males other than the alpha male. (
  • When an alpha male dies or wanders off, new alpha males - usually from an outside group - move in, and tend to try to kill infants from the previous regime. (
  • Workup in alpha thalassemia relies primarily on laboratory evaluation, hemoglobin electrophoresis, and genetic testing (alpha thalassemia mutations panel). (
  • The Alpha comes with a 12-megapixel main camera and a 2.1-megapixel front camera, and just like its flagship you can expect all the same photography features such as Dual Camera and Beauty Face among others. (
  • This hygroscopic quality can cause gel capsules not fully packed with alpha-GPC to dissolve. (
  • One-Alpha capsules, drops and injection all contain the active ingredient alfacalcidol, which is a form of vitamin D. (Alfacalcidol capsules are also available without a brand name, ie as the generic medicine. (
  • One-Alpha capsules and drops can be taken either with or without food. (
  • WHEREAS , Alpha-1 originates in the liver and can lead to liver failure at any time in life. (
  • You have a greater risk of having a child with the most severe type, alpha thalassemia major. (
  • The best way to diagnose alpha-1 is a test that looks at your DNA (genetic information. (
  • In addition to the presumed role of alpha-synuclein dynamics in synaptic function, changes in its physiological behavior may underlie the pathological changes associated with Parkinson's disease. (
  • 1. Know the capital investment required Examine the operating costs & raw materials consumption Alpha-Cyclodextrin is a polysaccharide and a multifunctional, soluble dietary fiber marketed for use as a fiber ingredient, an odor or flavor masking agent, and for emulsification applications. (
  • Alpha usually denotes a 'developer release' only. (
  • Alpha Ebot is to implement a software to interact with robots, this software using the bluetooth BLE protocol to transmit control command, implementation and robot interaction, let robot singing and dancing, tai chi, etc. (
  • Which drugs or supplements interact with alpha-1-proteinase inhibitor-injection? (
  • The Alpha Sigma Nu Jesuit Book Awards , established in 1979, recognize outstanding publishing achievement at Jesuit colleges and universities. (
  • In human s, alpha male behaviour and characteristic s are still noticeable althogh these can vary by social context . (
  • Using cultured rat cells, the researchers conducted experiments to find out more about how alpha-synuclein affects microglial activity. (
  • We find that these alphas arise primarily from the disproportionate weight the Fama-French factors place on small value stocks, which have performed well, and from the CRSP value-weighted market index, which is historically a downward-biased benchmark for U.S. stocks. (
  • Due to the lack of conclusive safety data, alpha-1 proteinase inhibitor should be used in pregnancy only if the potential benefit justifies the potential risk to the fetus. (