Plants whose roots, leaves, seeds, bark, or other constituent parts possess therapeutic, tonic, purgative, curative or other pharmacologic attributes, when administered to man or animals.
Any substances taken in by the body that provide nourishment.
The study of plant lore and agricultural customs of a people. In the fields of ETHNOMEDICINE and ETHNOPHARMACOLOGY, the emphasis is on traditional medicine and the existence and medicinal uses of PLANTS and PLANT EXTRACTS and their constituents, both historically and in modern times.
Systems of medicine based on cultural beliefs and practices handed down from generation to generation. The concept includes mystical and magical rituals (SPIRITUAL THERAPIES); PHYTOTHERAPY; and other treatments which may not be explained by modern medicine.
The production and movement of food items from point of origin to use or consumption.
Use of plants or herbs to treat diseases or to alleviate pain.
Concentrated pharmaceutical preparations of plants obtained by removing active constituents with a suitable solvent, which is evaporated away, and adjusting the residue to a prescribed standard.
Use of written, printed, or graphic materials upon or accompanying a food or its container or wrapper. The concept includes ingredients, NUTRITIONAL VALUE, directions, warnings, and other relevant information.
The selection of one food over another.
Measurement and evaluation of the components of substances to be taken as FOOD.
A system of traditional medicine which is based on the beliefs and practices of the African peoples. It includes treatment by medicinal plants and other materia medica as well as by the ministrations of diviners, medicine men, witch doctors, and sorcerers.
The study of the actions and properties of medicinal agents, often derived from PLANTS, indigenous to populations or ETHNIC GROUPS.
Material prepared from plants.
Acquired or learned food preferences.
The presence of bacteria, viruses, and fungi in food and food products. This term is not restricted to pathogenic organisms: the presence of various non-pathogenic bacteria and fungi in cheeses and wines, for example, is included in this concept.
The industry concerned with processing, preparing, preserving, distributing, and serving of foods and beverages.
Gastrointestinal disturbances, skin eruptions, or shock due to allergic reactions to allergens in food.
A species of European freshwater LEECHES used for BLOODLETTING in ancient times and also for LEECHING in modern times.
The presence in food of harmful, unpalatable, or otherwise objectionable foreign substances, e.g. chemicals, microorganisms or diluents, before, during, or after processing or storage.
A non-medical term defined by the lay public as a food that has little or no preservatives, which has not undergone major processing, enrichment or refinement and which may be grown without pesticides. (from Segen, The Dictionary of Modern Medicine, 1992)
Any aspect of the operations in the preparation, processing, transport, storage, packaging, wrapping, exposure for sale, service, or delivery of food.
Activities involved in ensuring the safety of FOOD including avoidance of bacterial and other contamination.
The traditional Hindu system of medicine which is based on customs, beliefs, and practices of the Hindu culture. Ayurveda means "the science of Life": veda - science, ayur - life.
Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.
Prepared food that is ready to eat or partially prepared food that has a final preparation time of a few minutes or less.
The withholding of food in a structured experimental situation.
Any food that has been supplemented with essential nutrients either in quantities that are greater than those present normally, or which are not present in the food normally. Fortified food includes also food to which various nutrients have been added to compensate for those removed by refinement or processing. (From Segen, Dictionary of Modern Medicine, 1992)
The study of medicines derived from botanical sources.
Annelids of the class Hirudinea. Some species, the bloodsuckers, may become temporarily parasitic upon animals, including man. Medicinal leeches (HIRUDO MEDICINALIS) have been used therapeutically for drawing blood since ancient times.
Food derived from genetically modified organisms (ORGANISMS, GENETICALLY MODIFIED).
The sequence of transfers of matter and energy from organism to organism in the form of FOOD. Food chains intertwine locally into a food web because most organisms consume more than one type of animal or plant. PLANTS, which convert SOLAR ENERGY to food by PHOTOSYNTHESIS, are the primary food source. In a predator chain, a plant-eating animal is eaten by a larger animal. In a parasite chain, a smaller organism consumes part of a larger host and may itself be parasitized by smaller organisms. In a saprophytic chain, microorganisms live on dead organic matter.
Functions, equipment, and facilities concerned with the preparation and distribution of ready-to-eat food.
The parts of plants, including SEEDS.
Laws and regulations concerned with industrial processing and marketing of foods.
Historically, the treatment of disease by the administration of animal organs or their extracts (after Brown-Sequard). At present synthetic preparations substitute for the extracts of a gland. (From Stedman, 26th ed)
Food that has been prepared and stored in a way to prevent spoilage.
Substances which are of little or no nutritive value, but are used in the processing or storage of foods or animal feed, especially in the developed countries; includes ANTIOXIDANTS; FOOD PRESERVATIVES; FOOD COLORING AGENTS; FLAVORING AGENTS; ANTI-INFECTIVE AGENTS (both plain and LOCAL); VEHICLES; EXCIPIENTS and other similarly used substances. Many of the same substances are PHARMACEUTIC AIDS when added to pharmaceuticals rather than to foods.
Behavioral responses or sequences associated with eating including modes of feeding, rhythmic patterns of eating, and time intervals.
The consumption of edible substances.
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
A system of traditional medicine which is based on the beliefs and practices of the Chinese culture.
Members of the group of vascular plants which bear flowers. They are differentiated from GYMNOSPERMS by their production of seeds within a closed chamber (OVARY, PLANT). The Angiosperms division is composed of two classes, the monocotyledons (Liliopsida) and dicotyledons (Magnoliopsida). Angiosperms represent approximately 80% of all known living plants.
An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.
Regular course of eating and drinking adopted by a person or animal.
The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).
Procedures or techniques used to keep food from spoiling.
Food processed and manufactured for the nutritional health of children in their first year of life.
Components of the usual diet that may provide health benefits beyond basic nutrients. Examples of functional foods include soy, nuts, chocolate, and cranberries (From NCCAM Backgrounder, March 2004, p3).
Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people in EAST ASIA.
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Foods made from SOYBEANS. Health benefits are ascribed to the high levels of DIETARY PROTEINS and ISOFLAVONES.
Food and dietary formulations including elemental (chemically defined formula) diets, synthetic and semisynthetic diets, space diets, weight-reduction formulas, tube-feeding diets, complete liquid diets, and supplemental liquid and solid diets.
The outer layer of the woody parts of plants.
Natural or synthetic dyes used as coloring agents in processed foods.
A mushroom, Ganoderma lucidum, of the POLYPORALES order of basidiomycetous fungi. It has long been used in traditional Chinese medicine in various forms.
Examination of foods to assure wholesome and clean products free from unsafe microbes or chemical contamination, natural or added deleterious substances, and decomposition during production, processing, packaging, etc.
The application of LEECHES to the body to draw blood for therapeutic purposes. Such medicinal leeching, an ancient medical practice, is still being used in microsurgery and the treatment of venous congestion or occlusion.
The above-ground plant without the roots.
The spurge family of flowering plants, in the order Euphorbiales, contains some 7,500 species in 275 genera. The family consists of annual and perennial herbs and woody shrubs or trees.
Materials or substances used in the composition of traditional medical remedies. The use of this term in MeSH was formerly restricted to historical articles or those concerned with traditional medicine, but it can also refer to homeopathic remedies. Nosodes are specific types of homeopathic remedies prepared from causal agents or disease products.
Individuals classified according to their sex, racial origin, religion, common place of living, financial or social status, or some other cultural or behavioral attribute. (UMLS, 2003)
The dried seeds, bark, root, stems, buds, leaves, or fruit of aromatic plants used to season food.
The application of knowledge to the food industry.
Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.
A plant family of the order Lamiales. It is characterized by simple leaves in opposite pairs, cystoliths (enlarged cells containing crystals of calcium carbonate), and bilaterally symmetrical and bisexual flowers that are usually crowded together. The common name for Ruellia of wild petunia is easily confused with PETUNIA.
Total number of calories taken in daily whether ingested or by parenteral routes.
A plant genus of the family EUPHORBIACEAE. Bahupatra (MEDICINE, AYURVEDIC) is prepared from this.
Foods and beverages prepared for use to meet specific needs such as infant foods.
A system of traditional medicine which is based on the beliefs and practices of the Tibetan culture.
Food or financial assistance for food given to those in need.
Expanded structures, usually green, of vascular plants, characteristically consisting of a bladelike expansion attached to a stem, and functioning as the principal organ of photosynthesis and transpiration. (American Heritage Dictionary, 2d ed)
Substances capable of inhibiting, retarding or arresting the process of fermentation, acidification or other deterioration of foods.
The fleshy or dry ripened ovary of a plant, enclosing the seed or seeds.
Poisoning by staphylococcal toxins present in contaminated food.
Process that is gone through in order for a drug to receive approval by a government regulatory agency. This includes any required pre-clinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance of the drug.
A plant genus of the family ORCHIDACEAE that contains dihydroayapin (COUMARINS) and phenanthraquinones.
The desire for FOOD generated by a sensation arising from the lack of food in the STOMACH.
A plant of the family APIACEAE which is the source of asiatic acid and asiaticoside. Centella asiatica (L.) Urb. = Hydrocotyle asiatica L. is known for effect on peripheral circulation.
Laws concerned with manufacturing, dispensing, and marketing of drugs.
Complex pharmaceutical substances, preparations, or matter derived from organisms usually obtained by biological methods or assay.
A monocot family within the order Liliales. This family is divided by some botanists into other families such as Convallariaceae, Hyacinthaceae and Amaryllidaceae. Amaryllidaceae, which have inferior ovaries, includes CRINUM; GALANTHUS; LYCORIS; and NARCISSUS and are known for AMARYLLIDACEAE ALKALOIDS.
Food that is grown or manufactured in accordance with nationally regulated production standards that include restrictions on the use of pesticides, non-organic fertilizers, genetic engineering, growth hormones, irradiation, antibiotics, and non-organic ingredients.
An extensive order of basidiomycetous fungi whose fruiting bodies are commonly called mushrooms.
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
The dogbane family of the order Gentianales. Members of the family have milky, often poisonous juice, smooth-margined leaves, and flowers in clusters. Asclepiadacea (formerly the milkweed family) has been included since 1999 and before 1810.
An indication of the contribution of a food to the nutrient content of the diet. This value depends on the quantity of a food which is digested and absorbed and the amounts of the essential nutrients (protein, fat, carbohydrate, minerals, vitamins) which it contains. This value can be affected by soil and growing conditions, handling and storage, and processing.
A plant genus of the family CELASTRACEAE.
A food group comprised of EDIBLE PLANTS or their parts.
The fruiting 'heads' or 'caps' of FUNGI, which as a food item are familiarly known as MUSHROOMS, that contain the FUNGAL SPORES.
A plant genus of the family RUTACEAE. Members contain quinoline alkaloids.
Production of drugs or biologicals which are unlikely to be manufactured by private industry unless special incentives are provided by others.
A series of actions, sometimes symbolic actions which may be associated with a behavior pattern, and are often indispensable to its performance.
Mechanical food dispensing machines.
A plant genus of the family SOLANACEAE. Members contain withanolides. Withania somnifera is the source of ashwagandha and aswal.
Poisoning caused by ingestion of food harboring species of SALMONELLA. Conditions of raising, shipping, slaughtering, and marketing of domestic animals contribute to the spread of this bacterium in the food supply.
The Madder plant family of the order Rubiales, subclass Asteridae, class Magnoliopsida includes important medicinal plants that provide QUININE; IPECAC; and COFFEE. They have opposite leaves and interpetiolar stipules.
Containers, packaging, and packaging materials for processed and raw foods and beverages. It includes packaging intended to be used for storage and also used for preparation of foods such as microwave food containers versus COOKING AND EATING UTENSILS. Packaging materials may be intended for food contact or designated non-contact, for example, shipping containers. FOOD LABELING is also available.
Root-like underground horizontal stem of plants that produces shoots above and roots below. Distinguished from true roots which don't have buds and nodes. Similar to true roots in being underground and thickened by storage deposits.
The medical science concerned with the prevention, diagnosis, and treatment of diseases in animals.
A plant genus in the family CONVOLVULACEAE best known for morning glories (a common name also used with CONVOLVULUS) and sweet potato.
A genus of fungi in the family Ganodermataceae, order POLYPORALES, containing a dimitic hyphal system. It causes a white rot, and is a wood decomposer. Ganoderma lucidum (REISHI) is used in traditional Chinese medicine (MEDICINE, CHINESE TRADITIONAL).
Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
Guidelines and objectives pertaining to food supply and nutrition including recommendations for healthy diet.
The mahogany plant family of the order Sapindales, subclass Rosidae, class Magnoliopsida.
A group of phenyl benzopyrans named for having structures like FLAVONES.
The usually underground portions of a plant that serve as support, store food, and through which water and mineral nutrients enter the plant. (From American Heritage Dictionary, 1982; Concise Dictionary of Biology, 1990)
The location of the atoms, groups or ions relative to one another in a molecule, as well as the number, type and location of covalent bonds.
The collective designation of three organizations with common membership: the European Economic Community (Common Market), the European Coal and Steel Community, and the European Atomic Energy Community (Euratom). It was known as the European Community until 1994. It is primarily an economic union with the principal objectives of free movement of goods, capital, and labor. Professional services, social, medical and paramedical, are subsumed under labor. The constituent countries are Austria, Belgium, Denmark, Finland, France, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Portugal, Spain, Sweden, and the United Kingdom. (The World Almanac and Book of Facts 1997, p842)
Systematic collections of factual data pertaining to the diet of a human population within a given geographic area.
The process of finding chemicals for potential therapeutic use.
A plant genus of the family EUPHORBIACEAE. The common name of dragon's blood is also used for DRACAENA and Daemonorops (ARECACEAE). Croton tiglium is the source of CROTON OIL.
Liquids that are suitable for drinking. (From Merriam Webster Collegiate Dictionary, 10th ed)
A type of glycoside widely distributed in plants. Each consists of a sapogenin as the aglycone moiety, and a sugar. The sapogenin may be a steroid or a triterpene and the sugar may be glucose, galactose, a pentose, or a methylpentose.
The science of drugs prepared from natural-sources including preparations from PLANTS, animals, and other organisms as well as MINERALS and other substances included in MATERIA MEDICA. The therapeutic usage of plants is PHYTOTHERAPY.
A plant species which is known as an Oriental traditional medicinal plant.
The showy mistletoe plant family of the order Santalales, subclass Rosidae, class Magnoliopsida. This includes parasitic tropical plants with haustoria connecting to the hosts. The leaves are opposite and thick. The flowers (4-7) have both calyx and corolla. The fruit is a berry with one seed.
The protection, preservation, restoration, and rational use of all resources in the total environment.
Naturally occurring or synthetic substances that inhibit or retard the oxidation of a substance to which it is added. They counteract the harmful and damaging effects of oxidation in animal tissues.
A plant genus of the family POLYGONACEAE that is an ingredient of Shou-Wu-Pian, a Chinese herbal preparation (DRUGS, CHINESE HERBAL). The common name of black bindweed also refers to TAMUS or Fallopia (use POLYGONACEAE).
A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.
A large plant genus of the family EUPHORBIACEAE, order Euphorbiales, subclass Rosidae. They have a milky sap and a female flower consisting of a single pistil, surrounded by numerous male flowers of one stamen each. Euphorbia hirta is rarely called milkweed but that name is normally used for ASCLEPIAS.
Hospital department that manages and supervises the dietary program in accordance with the patients' requirements.
A plant family of the order Violales, subclass Dilleniidae, class Magnoliopsida. Bixa contains bixin. Cochlospermum contains arjunolic acid and gum kondagogu (POLYSACCHARIDES).
The interchange of goods or commodities, especially on a large scale, between different countries or between populations within the same country. It includes trade (the buying, selling, or exchanging of commodities, whether wholesale or retail) and business (the purchase and sale of goods to make a profit). (From Random House Unabridged Dictionary, 2d ed, p411, p2005 & p283)
A plant genus of the family ASTERACEAE with strong-smelling foliage. It is a source of SANTONIN and other cytotoxic TERPENES.
The mallow family of the order Malvales, subclass Dilleniidae, class Magnoliopsida. Members include GOSSYPIUM, okra (ABELMOSCHUS), HIBISCUS, and CACAO. The common names of hollyhock and mallow are used for several genera of Malvaceae.
A genus of ascomycetous fungi (ASCOMYCOTA), family Clavicipitaceae, order HYPOCREALES, that grows by infecting insect larvae or mature insects with spores that germinate often before the cocoon is formed.
A plant genus of the family CELASTRACEAE that is a source of triterpenoids and diterpene epoxides such as triptolide.
A plant genus of the family BERBERIDACEAE which is used in DRUGS, CHINESE HERBAL. Members contain flavonol glycosides including epimedins, icariin and noricariin.
A plant genus of the family MELIACEAE. Members contain azadirachtin A (a limonoid commonly referred to as azadirachtin) and other TRITERPENES. They have been used in PESTICIDES. The old name of Melia azadirachta is very similar to a related plant, MELIA AZEDARACH.
A genus of basidiomyceteous fungi in the family POLYPORACEAE found mostly on living trees or dead wood.
An endosymbiont that is either a bacterium or fungus living part of its life in a plant. Endophytes can benefit host plants by preventing pathogenic organisms from colonizing them.
A plant species of the genus SCUTELLARIA, family LAMIACEAE, that contains skullcapflavone and is used in CHINESE HERBAL DRUGS.
A plant genus of the family ZINGIBERACEAE that contains CURCUMIN and curcuminoids.
A plant genus of the family COMBRETACEAE. Members contain arjunin, an ellagitannin (TANNINS).
Knowledge, attitudes, and associated behaviors which pertain to health-related topics such as PATHOLOGIC PROCESSES or diseases, their prevention, and treatment. This term refers to non-health workers and health workers (HEALTH PERSONNEL).
Preclinical testing of drugs in experimental animals or in vitro for their biological and toxic effects and potential clinical applications.
A basidiomycetous fungal genus of the family Agaricaceae, order Agaricales, which includes the field mushroom (A. campestris) and the commercial mushroom (A. bisporus).
A plant species of the family EUPHORBIACEAE.
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Acute illnesses, usually affecting the GASTROINTESTINAL TRACT, brought on by consuming contaminated food or beverages. Most of these diseases are infectious, caused by a variety of bacteria, viruses, or parasites that can be foodborne. Sometimes the diseases are caused by harmful toxins from the microbes or other chemicals present in the food. Especially in the latter case, the condition is often called food poisoning.
Agents obtained from higher plants that have demonstrable cytostatic or antineoplastic activity.
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
The wood fern plant family of the order Polypodiales, class Filicopsida, division Pteridophyta.
Ratings of the characteristics of food including flavor, appearance, nutritional content, and the amount of microbial and chemical contamination.
The science, art or practice of cultivating soil, producing crops, and raising livestock.
A plant genus of the family Lamiaceae. The species of Coleus should be distinguished from PLECTRANTHUS BARBATUS - which is also known as Coleus forskohlii.
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
A plant genus of the family ASTERACEAE that has long been used in folk medicine for treating wounds.
Records of nutrient intake over a specific period of time, usually kept by the patient.
A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.
A plant genus of the family FABACEAE.
A plant genus in the family CAPRIFOLIACEAE known for elderberries.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
An order of fungi in the phylum BASIDIOMYCOTA having macroscopic basidiocarps. The members are characterized by their saprophytic activities as decomposers, particularly in the degradation of CELLULOSE and LIGNIN. A large number of species in the order have been used medicinally. (From Alexopoulos, Introductory Mycology, 4th ed, pp504-68)
An aromatic perennial plant species that has been used to treat migraines, arthritis, and as a febrifuge. It contains TANNINS, volatile oils (OILS, ESSENTIAL), and sesquiterpene lactones, especially parthenolide.
The effect of herbs, other PLANTS, or PLANT EXTRACTS on the activity, metabolism, or toxicity of drugs.
Natural recurring desire for food. Alterations may be induced by APPETITE DEPRESSANTS or APPETITE STIMULANTS.
Parts of plants that usually grow vertically upwards towards the light and support the leaves, buds, and reproductive structures. (From Concise Dictionary of Biology, 1990)
The molecular designing of drugs for specific purposes (such as DNA-binding, enzyme inhibition, anti-cancer efficacy, etc.) based on knowledge of molecular properties such as activity of functional groups, molecular geometry, and electronic structure, and also on information cataloged on analogous molecules. Drug design is generally computer-assisted molecular modeling and does not include pharmacokinetics, dosage analysis, or drug administration analysis.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
A plant genus of the family ASTERACEAE, order Asterales, subclass Asteridae. It is a source of costus root oil and should not be confused with the genus COSTUS.
Compounds formed by condensation of secologanin with tryptamine resulting in a tetrahydro-beta-carboline which is processed further to a number of bioactive compounds. These are especially found in plants of the APOCYNACEAE; LOGANIACEAE; and RUBIACEAE families.
It is the study of social phenomena which characterize the learned, shared, and transmitted social activities of particular ethnic groups with focus on the causes, consequences, and complexities of human social and cultural variability.
Liquid chromatographic techniques which feature high inlet pressures, high sensitivity, and high speed.
A plant genus of the family ASTERACEAE. The common names of daisy or marguerite are easily confused with other plants. Some species in this genus have been reclassified to TANACETUM.
Ergostane derivatives of 28 carbons with oxygens at C1, C22, and C26 positions and the side chain cyclized. They are found in WITHANIA plant genus and have cytotoxic and other effects.
A plant genus of the family Apocynaceae. It is the source of VINCA ALKALOIDS, used in leukemia chemotherapy.
A plant genus of the family GENTIANACEAE. It is a source of swertiapuniside and IRIDOID GLYCOSIDES.
A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)
The concentration of a compound needed to reduce population growth of organisms, including eukaryotic cells, by 50% in vitro. Though often expressed to denote in vitro antibacterial activity, it is also used as a benchmark for cytotoxicity to eukaryotic cells in culture.
The edible portions of any animal used for food including domestic mammals (the major ones being cattle, swine, and sheep) along with poultry, fish, shellfish, and game.
Physiologic mechanisms which regulate or control the appetite and food intake.
Predetermined sets of questions used to collect data - clinical data, social status, occupational group, etc. The term is often applied to a self-completed survey instrument.
Medical practice or discipline that is based on the knowledge, cultures, and beliefs of the people of KOREA.
A plant genus of the family ARACEAE that contains pinellian (an acidic polysaccharide). The plant is an ingredient of some traditional Asian medicinal mixtures including sho-saiko-to, saiko-keishi-to, and banxia houpu decoction.
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
An independent state in eastern Africa. Ethiopia is located in the Horn of Africa and is bordered on the north and northeast by Eritrea, on the east by Djibouti and Somalia, on the south by Kenya, and on the west and southwest by Sudan. Its capital is Addis Ababa.
A plant genus of the family SIMAROUBACEAE. Members produce quassinoids.
That segment of commercial enterprise devoted to the design, development, and manufacture of chemical products for use in the diagnosis and treatment of disease, disability, or other dysfunction, or to improve function.
A kingdom of eukaryotic, heterotrophic organisms that live parasitically as saprobes, including MUSHROOMS; YEASTS; smuts, molds, etc. They reproduce either sexually or asexually, and have life cycles that range from simple to complex. Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies.
A plant genus of the family CAPRIFOLIACEAE. Members contain iridoid glucosides.
A plant family of the order Primulales, subclass Dilleniidae, class Magnoliopsida. The flowers have both stamens and pistil, and the fruits are capsules.
Full gratification of a need or desire followed by a state of relative insensitivity to that particular need or desire.
Seeds from grasses (POACEAE) which are important in the diet.
The processes and properties of living organisms by which they take in and balance the use of nutritive materials for energy, heat production, or building material for the growth, maintenance, or repair of tissues and the nutritive properties of FOOD.
A plant genus of the family FABACEAE. Many species of this genus, including the medicinal C. senna and C. angustifolia, have been reclassified into the Senna genus (SENNA PLANT) and some to CHAMAECRISTA.
A plant genus of the family PIPERACEAE that includes species used for spicy and stimulating qualities.
A plant genus of the family ASTERACEAE. Members contain germacrane and sesquiterpene LACTONES.
A large class of organic compounds having more than one PHENOL group.
A genus of leguminous herbs or shrubs whose roots yield GLYCYRRHETINIC ACID and its derivative, CARBENOXOLONE.
Twenty-carbon compounds derived from MEVALONIC ACID or deoxyxylulose phosphate.
Behavioral response associated with the achieving of gratification.
The relationship between the dose of an administered drug and the response of the organism to the drug.
"Natural products as aromatase inhibitors". Anti-Cancer Agents in Medicinal Chemistry. 8 (6): 646-82. doi:10.2174/ ... Food and Chemical Toxicology. 40 (7): 925-33. doi:10.1016/S0278-6915(02)00066-2. PMID 12065214.. ... Pharmaceutical aromatase inhibitorsEdit. Main article: Aromatase inhibitor. Aromatase inhibitors, which stop the production of ... Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also ...
An Investigation into the Antimicrobial Activities of Medicinal Food Plants of Mauritius». Journal of Food Science. doi:10.1111 ... Biodiversity As A Source of Selective Inhibitors of CHIKV Replication». Antiviral Research. doi:10.1016/j.antiviral.2011.03.048 ... Mahomoodally, M. F.; Subratty, A. H.; Gurib-Fakim, A.; Choudhary, M. I.; Khan, S. N.. «Traditional Medicinal Herbs and Food ... Subratty, A. H.; Gurib-Fakim, A.; Mahomoodally, F.. «Bitter melon: an exotic vegetable with medicinal values». Nutrition & Food ...
Idelalisib is the first PI3K inhibitor approved by the US Food and Drug Administration and is utilized in the treatment of ... Medicinal Chemistry Letters. 27: 2838-2848. doi:10.1016/j.bmcl.2017.04.090.. ... PI3K inhibitorEdit. PI3K inhibitors may overcome drug resistance and improve advanced breast cancer (ABC) outcomes.[14] ... PTEN is a natural inhibitor of the PI3K/AKT pathway. Bisperoxovanadium is a specific inhibitor of PTEN's phosphatase activity[ ...
Journal of Agricultural and Food Chemistry. 53 (5): 1765-1768. doi:10.1021/jf040019b. ISSN 0021-8561. PMID 15740071.. ... "Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family ... Reversible inhibitor[edit]. Compounds which function as reversible competitive or noncompetitive inhibitors of cholinesterase ... Quasi-irreversible inhibitor[edit]. Compounds which function as quasi-irreversible inhibitors of cholinesterase are those most ...
Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also ... Food and Chemical Toxicology. 40 (7): 925-33. doi:10.1016/S0278-6915(02)00066-2. PMID 12065214. Kapiszewska M, Miskiewicz M, ... Anti-Cancer Agents in Medicinal Chemistry. 8 (6): 646-82. doi:10.2174/1871520610808060646. PMC 3074486. PMID 18690828. Satoh K ... "Aromatase Inhibitors". Attar E, Bulun SE (May 2006). "Aromatase inhibitors: the next generation of ...
Journal of Medicinal Food. 11 (4): 643-51. doi:10.1089/jmf.2007.0629. PMID 19053855.. ... Matsuur H, Asakawa C, Kurimoto M, Mizutani J (July 2002). "Alpha-glucosidase inhibitor from the seeds of balsam pear (Momordica ... Journal of Medicinal Food. 6 (4): 371-7. doi:10.1089/109662003772519949. PMID 14977447.. ... Journal of Medicinal Food. 7 (2): 141-5. doi:10.1089/1096620041224012. PMID 15298759.. ...
Journal of Medicinal Food. 11 (4): 643-51. doi:10.1089/jmf.2007.0629. PMID 19053855.. ... In particular, the following foods contain significant inhibitors and have been suggested as part of a healthy diet for this ... Angiogenesis Inhibitors for Cancer - from The Angiogenesis Foundation, 23 June 2009. *Angiogenesis Inhibitors for Eye Disease ... In animal studies, high doses of inhibitors were required to prevent tumor growth and the use of endogenous inhibitors would ...
Kinase Inhibitor (GDC-0980) for the Treatment of Cancer". Journal of Medicinal Chemistry. 54 (21): 7579-87. doi:10.1021/ ... "Food and Drug Administration. Retrieved 25 September 2012.. *^ "Rapamune". European Medicines Agency. Retrieved 25 September ... PI3K inhibitor. References[edit]. *^ a b c d e f g h i j k l Pópulo, Helena; Lopes, José Manuel; Soares, Paula (2012). "The ... The second generation of mTOR inhibitors is known as ATP-competitive mTOR kinase inhibitors.[7] mTORC1/mTORC2 dual inhibitors ...
Phosphoinositide 3-kinase inhibitor Idelalisib "Full prescribing information: COPIKTRA (duvelisib)" (PDF). U.S. Food and Drug ... On 25 March 2021, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a ... It is a dual inhibitor of PI3Kδ and PI3Kγ. Duvelisib is manufactured by Verastem Oncology. It is used to treat chronic ... Duvelisib is a Phosphoinositide 3-kinase inhibitor, specifically of the delta and gamma isoforms of PI3K. This class of ...
"United States Food and Drug Administration. April 2015. Archived from the original on 18 September 2015. Retrieved 7 March 2016 ... Non-medicinal usageEdit. In a study of psychoactive effects of levomethamphetamine, the intravenous administration of 0.5 mg/kg ... It is a selective MAOB inhibitor at normal clinical doses. MAOB is an enzyme that metabolizes dopamine, the neurotransmitter ... Tabakman R, Lecht S, Lazarovici P (2004). "Neuroprotection by monoamine oxidase B inhibitors: a therapeutic strategy for ...
Kellenberger E, Kuhn I, Schuber F, Muller-Steffner H (2011). "Flavonoids as inhibitors of human CD38". Bioorganic & Medicinal ... Food Chemistry. 107 (1): 200-207. doi:10.1016/j.foodchem.2007.08.005. M. Gábor; E. EperJessy (10 December 1966). "Antibacterial ...
In 1987, the first drug for the treatment of HIV infection was approved by the U.S. Food and Drug Administration (FDA). This ... Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU)". Bioorganic & Medicinal Chemistry Letters. 11 ... Antiretroviral drug Reverse-transcriptase inhibitor Protease inhibitor Entry inhibitor Discovery and development of HIV- ... Inhibitor flexibility may not affect the inhibitor-target interactions. The NNRTIs act by binding non-competitively to the RT ...
Many medicinal drugs can lead to pulmonary toxicity. A few medicinal drugs can lead to pulmonary toxicity frequently (in ... These include above all amiodarone, as well as beta blockers, ACE inhibitors (however, pulmonary toxicity of ACE inhibitors ... medicine defined by international regulatory authorities such as the U.S. Food and Drug Administration and the EMEA [European ... The treatment of pulmonary toxicity due to medicinal drugs is to discontinue (= to stop taking) the medicinal drug in question ...
In May 2005, the U.S. Food and Drug Administration found that tadalafil (along with other PDE5 inhibitors) was associated with ... Sriram D. Medicinal Chemistry. Pearson Education India, 2010. p. 635.. *^ Kaye K. Gaines. "Tadalafil (Cialis) and Vardenafil ( ... "Food and Drug Administration. 2007-10-18. Archived from the original on 2016-10-22. Retrieved 2009-09-28.. ... Comparison with actions of other PDE5 inhibitors[edit]. Tadalafil, sildenafil, and vardenafil all act by inhibiting the PDE5 ...
"Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers". U.S. Food and Drug Administration. U.S. ... Medicinal Chemistry. 13 (20): 5819-25. doi:10.1016/j.bmc.2005.05.071. PMID 16084098. "Drug Development and Drug Interactions: ... Pan X, Tan N, Zeng G, Zhang Y, Jia R (October 2005). "Amentoflavone and its derivatives as novel natural inhibitors of human ... Park JY, Kim KA, Kim SL (November 2003). "Chloramphenicol is a potent inhibitor of cytochrome P450 isoforms CYP2C19 and CYP3A4 ...
"Structure-Based Design of Novel Potent Nonpeptide Thrombin Inhibitors". Journal of Medicinal Chemistry. 45 (9): 1757-1766. doi: ... Warfarin has its disadvantages though, just like heparin, such as a narrow therapeutic index and multiple food and drug ... Direct thrombin inhibitors (DTIs) are a class of anticoagulant drugs that can be used to prevent and treat embolisms and blood ... Most of those drugs are in the class of direct factor Xa inhibitors, but there is one DTI called AZD0837, which is a follow-up ...
Discovery and development of mTOR inhibitors Lemke, Thomas (2008). Foye's principles of medicinal chemistry. Philadelphia: ... On 29 October 2010, a new cephalosporin agent - Ceftarolin - was approved by the food and drug administration (FDA). Teflaro ( ... by Frank D. (2002). Medicinal chemistry : principles and practice (2. ed.). Cambridge: Royal Soc. of Chemistry. ISBN 978-0- ... "Discovery of New Inhibitors of ResistantStreptococcus pneumoniaePenicillin Binding Protein (PBP) 2x by Structure-Based Virtual ...
"Pharmacological actions of the South African medicinal and functional food plant Sceletium tortuosum and its principal ... selective inhibitor of the serotonin transporter (SERT) (that is, a selective serotonin reuptake inhibitor; Ki = 27 nM) and ... also a phosphodiesterase 4 (PDE4) inhibitor (Ki = 470 nM). Mesembrine another alkaloid constituent of Kanna. Harvey, A. L.; ...
Development of dipeptidyl peptidase-4 inhibitors "FDA Approves New Treatment for Diabetes" (Press release). U.S. Food and Drug ... Annual Reports in Medicinal Chemistry. 48: 523-524. doi:10.1016/b978-0-12-417150-3.00028-4. "Merck MARIZEV Once-Weekly DPP-4 ... Inhibitors of dipeptidyl peptidase 4, also DPP-4 inhibitors or gliptins, are a class of oral hypoglycemics that block DPP-4 ( ... The U.S. Food and Drug Administration (FDA) is warning that the type 2 diabetes medicines like sitagliptin, saxagliptin, ...
... (INN) is a non-β-lactam β-lactamase inhibitor discovered by Rempex Pharmaceuticals, a subsidiary of The Medicines ... In the United States, the combination drug meropenem/vaborbactam (Vabomere) is approved by the Food and Drug Administration for ... Journal of Medicinal Chemistry. 58 (9): 3682-92. doi:10.1021/acs.jmedchem.5b00127. PMID 25782055. "FDA approves new ... Vaborbactam, however, is a highly specific β-lactamase inhibitor, with an IC50 >> 1 mM against all human serine hydrolases ...
"Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening". Journal of Medicinal Chemistry. 44 ... "FDA approves venetoclax for CLL or SLL, with or without 17p deletion, after one prior therapy". U.S. Food and Drug ... This was the first FDA approval of a BCL-2 inhibitor. In June 2018, the FDA broadened the approval for anyone with CLL or small ... In the mid-2000s, Abbott Laboratories developed a novel inhibitor of Bcl-2, Bcl-xL and Bcl-w, known as ABT-737. This compound ...
ISBN 978-0-444-52824-7. "Pemfexy: FDA-Approved Drugs". U.S. Food and Drug Administration (FDA). Retrieved 13 February 2020. ... Avendano, Carmen; Menendez, J. Carlos (April 2008). Medicinal Chemistry of Anticancer Drugs. Amsterdam: Elsevier. p. 37. ... "Pharmacokinetic and Pharmacodynamic Evaluation of the Glycinamide Ribonucleotide Formyltransferase Inhibitor AG2034". Clinical ... Food and Drug Administration (FDA) approved pemetrexed for treatment of malignant pleural mesothelioma, a type of tumor of the ...
Additionally, injection of α-FMH has been shown to increase food intake, although the mechanism is believed to distinct from ... α-Fluoromethylhistidine (α-FMH) is an irreversible specific inhibitor of histidine decarboxylase (HDC). It functions by forming ... Medicinal Chemistry Letters. 27 (6): 1335-1340. doi:10.1016/j.bmcl.2017.02.024. PMID 28228363. v t e v t e. ... August 1985). "Bioanalysis and disposition of alpha-fluoromethylhistidine, a new histidine decarboxylase inhibitor". Journal of ...
Lim, T. K. (2015). Edible Medicinal and Non Medicinal Plants. Dordrecht: Springer Netherlands. p. 802. doi:10.1007/978-94-017- ... Historically, maca often was traded for lowland tropical food staples, such as maize, rice, manioc (tapioca roots), quinoa, and ... in the extracts of maca indicate a potential safety issue as a monoamine oxidase inhibitor (re. which see β-carboline) and ... Maca has been marketed for its supposed traditional medicinal effects, though evidence that it has effects on human health or ...
They are usually included in the category of foods as they are usually taken as a tea or food supplement. However, medicinal ... Some foods also act as inductors or inhibitors of enzymatic activity. The following table shows the most common: Any study of ... The interaction between a medicinal plant and a drug is usually overlooked due to a belief in the "safety of medicinal plants ... one inductor and the other inhibitor or both inhibitors, which greatly complicates the control of an individual's medication ...
Curcumin Desmethoxycurcumin T. K. Lim (11 February 2016). Edible Medicinal and Non-Medicinal Plants: Volume 12 Modified Stems, ... ISBN 978-4-431-67017-9. Jun-Ping Xu (25 November 2016). Cancer Inhibitors from Chinese Natural Medicines. CRC Press. p. 338. ... ISBN 978-1-4987-8766-6. Francisco Delgado-Vargas; Octavio Paredes-Lopez (26 December 2002). Natural Colorants for Food and ... Food Factors for Cancer Prevention. Springer Science & Business Media. p. 251. ...
... is generally not indicated for food or medicinal allergies. This therapy is particularly useful for people with ... Glucocorticoids are somewhat more specific inhibitors of lymphocyte activation, whereas inhibitors of immunophilins more ... "T cells isolated from patients with checkpoint inhibitor resistant-melanoma are functional and can mediate tumor regression". ...
Lysianadioic acid, a carboxypeptidase B inhibitor from Lysiana subfalcata Bio-organic & Medicinal Chemistry Letters 18 (2008) ... p.151 Cribb, A.B. & J.W. (1976). Wild Food in Australia. Fontana Books. p. 43 Isaacs, J.(1987). Bushfood: Aboriginal food and ... It is a potent inhibitor of CPB with an IC50 of 0.36 lM. This is the first known example of a small molecule CPB inhibitor ... L. exocarpi is a host plant for Ogyris aenone and is a popular food plant for nectar feeding birds when in full flower. The ...
Water fraction of edible medicinal fern Stenochlaena palustris is a potent α-glucosidase inhibitor with concurrent antioxidant ... In the Malaysian state of Sarawak, the plant is called "Midin". It is a popular food among the locals. The young fronds are ... "NTFP". Compendium of medicinal plants used in Malaysia. 2002, vol 2. Herbal Medicine Research Centre, Institute for Medical ... Medicinal pteridophytes from the Western Ghats. Indian Journal of Traditional Knowledge. 6: 611-618. Tanaka, Yoshitaka; Van Ke ...
Food Chem. 1996; 44(8): 2020-2025. Berrin, K. & Larco Museum (1997). The Spirit of Ancient Peru: Treasures from the Museo ... A negative aspect of caigua is, that the seeds contain a group of trypsin inhibitors, which negatively affect protein ... and in vitro inhibitory potential against key enzymes relevant for hyperglycemia and hypertension of commonly used medicinal ... The fruits are eaten after removing the seeds and stuffing them with other foods like rice or meat, and then cooking them. ...
The US Food and Drug Administration (FDA) granted the application for selpercatinib priority review, orphan drug, and ... Selpercatinib is a kinase inhibitor, meaning it blocks a type of enzyme (kinase) and helps prevent the cancer cells from ... On 10 December 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a ... "FDA Approves First Therapy for Patients with Lung and Thyroid Cancers with a Certain Genetic Mutation or Fusion". U.S. Food and ...
The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication. Elagolix is used in the treatment ... OATP1B1 inhibitors are likely to greatly increase exposure to elagolix similarly to moderate to severe hepatic impairment. ... Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. ... Inhibitors of OATP1B1 may increase circulating levels of elagolix, and elagolix is considered to be contraindicated in ...
Two such inhibitors, Sonidegib and Vismodegib have been approved by the Food and Drug Administration (FDA) for treating basal ... Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS medicinal chemistry letters. 2011 Dec ... At least three Hedgehog pathway inhibitors have been approved by the Food and Drug Administration (FDA) for cancer treatment. ... GDC-0449-a potent inhibitor of the hedgehog pathway. Bioorganic & medicinal chemistry letters. 2009 Oct 1;19(19):5576-81. Pan S ...
On 26 May 2010, the U.S. Food and Drug Administration (FDA) approved a revised label for Xenical to include new safety ... Its primary function is preventing the absorption of fats from the human diet by acting as a lipase inhibitor, thereby reducing ... Journal of Medicinal Chemistry. 37 (3): 408-14. doi:10.1021/jm00029a013. PMID 8308867. Hanessian, Stephen; Tehim, Ashok; Chen, ... In January 2010, the U.S. Food and Drug Administration issued an alert stating that some counterfeit versions of Alli sold over ...
Food Chem. 63 (4): 1053-1056. doi:10.1021/jf504500g. PMID 25594104. Potts, L. F.; Luzzio, F. A.; Smith, S. C.; Hetman, M; ... Eposti, M (1 July 1994). "Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial ... A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and ...
It is the first in this particular drug class, sodium-glucose co-transporter 2 (SGLT2) inhibitors, to be approved to treat ... In 2012, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) issued a positive ... In 2020, the U.S. Food and Drug Administration (FDA) expanded the indications for dapagliflozin to include treatment for adults ... It is of the gliflozin (SGLT2 inhibitor) class. It was developed by Bristol-Myers Squibb in partnership with AstraZeneca. In ...
... is a reuptake inhibitor of serotonin and norepinephrine, or a serotonin-norepinephrine reuptake inhibitor (SNRI), and ... at 3 hours without food and 0.951 ng/mL (3.40 nmol/L) at 6 hours with food. Plasma concentrations of doxepin with ... Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. ... Doxepin has been identified as an inhibitor of CYP2D6 in vivo in a study of human patients being treated with 75 to 250 mg/day ...
Foods are often irradiated to kill harmful pathogens. Common sources of radiation used in food sterilization include cobalt-60 ... Some influenza A and B viruses have become resistant to neuraminidase inhibitors such as oseltamivir, and the search for new ... Kalemba D, Kunicka A (May 2003). "Antibacterial and antifungal properties of essential oils". Current Medicinal Chemistry. 10 ( ... "Irradiation of Food FAQ: What is the actual process of irradiation?". U.S. Centers for Disease Control and Prevention. Archived ...
In food systems, 2,5-diketopiperazines have been shown to be important sensory compounds contributing to the taste of the final ... These include tadalafil (a PDE5 inhibitor for erectile dysfunction), retosiban (an oxytocin antagonist for preterm labor), ... Borthwick AD (May 2012). "2,5-Diketopiperazines: Synthesis, Reactions, Medicinal Chemistry, and Bioactive Natural Products". ... In addition, they are often produced as degradation products of polypeptides, especially in processed food and beverages, and ...
Also in trials for CRPC are : checkpoint inhibitor ipilimumab, CYP17 inhibitor galeterone (TOK-001), and immunotherapy PROSTVAC ... "FDA approves Zytiga for late-stage prostate cancer". U.S. Food and Drug Administration. 2011-04-28. Archived from the original ... Medicinal Research Reviews. 39 (3): 910-960. doi:10.1002/med.21548. PMC 6608750. PMID 30565725. Ghosh J, Myers CE (October 1998 ... While the commonly used inhibitors produced strong cytotoxicity, notably, zileuton, the only commercialized 5-LOX inhibitor, ...
Kent, Michael, 1950-. Food and fitness : a dictionary of diet and exercise (2 ed.). [Oxford]. ISBN 978-0-19-180323-9. OCLC ... Raspberry leaf is used because it has no toxic connotations, nor is a medicinal substance, and has nutrients believed to tone ... Xu J (2017). Cancer inhibitors from Chinese natural medicines. Boca Raton: CRC Press. ISBN 978-1-315-36675-3. OCLC 1077760069. ... They are found in not only hospitals and pharmacies, but in health food stores and supermarkets as well. Although the use of ...
Exorphins include opioid food peptides like Gluten exorphin and opioid food peptides and are mostly contained in cereals and ... Opiorphin and spinorphin, enkephalinase inhibitors (i.e., prevent the metabolism of enkephalins). Hemorphins, hemoglobin- ... Future Medicinal Chemistry. 4 (2): 205-226. doi:10.4155/fmc.11.195. PMC 3306179. PMID 22300099. Table 1: Endogenous opioid ... and the control of food intake. Opioid-like peptides may also be absorbed from partially digested food (casomorphins, exorphins ...
7,8-DHF has been found to act as a weak aromatase inhibitor in vitro (Ki = 10 μM), though there is evidence to suggest that ... Structure−Activity Relationship†". Journal of Agricultural and Food Chemistry. 44 (2): 497-501. doi:10.1021/jf950378u. ISSN ... Journal of Medicinal Chemistry. 53 (23): 8274-8286. doi:10.1021/jm101206p. ISSN 0022-2623. PMC 3150605. PMID 21073191.. ...
Food and Chemical Toxicology, 48(1):93-98, 2010. B. V. Davidov A. Ya. Potapenko, V. L. Sukhorukov. A comparison between skin- ... For example, angelicin enhances the toxicity of psoralen by acting as an inhibitor of the detoxifying cytochrome P450 in ... Medicinal Chemistry Research. 26 (4): 849-855. doi:10.1007/s00044-017-1796-y. ISSN 1054-2523. S2CID 31293666. "BioByte". www. ... Humans also attempted to harvest the plants as an alternative food source. However, most of them turned out to be unpalatable ...
... but not with an integrase strand transferase inhibitor (INSTI) class drug. The U.S. Food and Drug Administration (FDA) granted ... In the European Union it is indicated, in combination with other anti-retroviral medicinal products, for the treatment of Human ... Dolutegravir is an HIV integrase strand transfer inhibitor which blocks the functioning of HIV integrase which is needed for ... In February 2013, the U.S. Food and Drug Administration (FDA) announced that it would fast track dolutegravir's approval ...
Some specific foods are linked to specific cancers. A high-salt diet is linked to gastric cancer. Aflatoxin B1, a frequent food ... Aspirin has been found to reduce the risk of death from cancer by about 7%. COX-2 inhibitors may decrease the rate of polyp ... Holick MF (January 2013). "Vitamin D, sunlight and cancer connection". Anti-Cancer Agents in Medicinal Chemistry. 13 (1): 70-82 ... Angiogenesis inhibitors were once incorrectly thought to have potential as a "silver bullet" treatment applicable to many types ...
The observed toxification symptoms conform to other acetylcholinesterase inhibitors. Symptoms are as follows: Colic Diarrhea ... non-food buildings. Diazinon was heavily used during the 1970s and early 1980s for general-purpose gardening use and indoor ... Medicinal Treatments; including the antidotes atropine and oxime. Gastric Lavage[citation needed] Patients that continue to ... inhibitor. This enzyme breaks down the neurotransmitter acetylcholine (ACh) into choline and an acetate group. The inhibition ...
... brain levels can be increased 1000-fold when taking a monoamine oxidase inhibitor (MAOI), particularly a MAO-B inhibitor, and ... In addition to its presence in mammals, phenethylamine is found in many other organisms and foods, such as chocolate, ... Wimalasena K (July 2011). "Vesicular monoamine transporters: structure-function, pharmacology, and medicinal chemistry". Med ... a selective inhibitor of MAO-B, is used in the treatment of Parkinson's disease and produces a marked increase in brain levels ...
It is found in Vitis vinifera grapevines, in wines, in the Oriental medicinal plant Vitis coignetiae and in the stem bark of ... is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity". European Journal of ... Journal of Agricultural and Food Chemistry. 50 (5): 1213-1217. doi:10.1021/jf010676t. PMID 11853506. Langcake, P.; Pryce, R. J ... Journal of Agricultural and Food Chemistry. 53 (14): 5664-5669. doi:10.1021/jf050122g. PMID 15998130. Wibowo, A.; Ahmat, N.; ...
EFSA Panel on Food Additives and Nutrient Sources Added to Food (ANS) (2013). "Scientific Opinion on the evaluation of the ... Yohimbe is the common English name for the tree species P. johimbe and, by extension, the name of a medicinal preparation made ... It has been largely superseded by the PDE5 inhibitor drugs such as sildenafil (Viagra). Prescription are now rare, and most US ... Because of the lack of reliable scientific data on yohimbe, the European Food Safety Authority Panel on Food Additives ...
Li Chang-wei, Cui Cheng-bin, Cai Bing, Han Bing, Li Ming-ming and Fan Ming, Chinese Journal of Medicinal Chemistry, 2009, 19 (1 ... European Food Research and Technology. 214 (5): 388. doi:10.1007/s00217-002-0498-x. S2CID 84221785. Kim, Ki Cheon; Kim, Jin ... "Inhibitors of Osteoclast Differentiation fromCephalotaxus koreana". Journal of Natural Products. 70 (12): 2029-32. doi:10.1021/ ... Food Chemistry. 139 (1-4): 35-43. doi:10.1016/j.foodchem.2013.01.117. PMID 23561075. Biotransformation of (+)-catechin by plant ...
Preclinical data suggest the possibility of interactions between bilastine and drugs or food that are inhibitors or inducers of ... Annual Reports in Medicinal Chemistry. 46. 2011. pp. 531-551. doi:10.1016/B978-0-12-386009-5.00035-7. ISBN 9780123860095. ... Bailey DG (2010). "Fruit juice inhibition of uptake transport: a new type of food-drug interaction". Br. J. Clin. Pharmacol. 70 ... a metabolism inhibitor and a P-gP dependent transport system. It was verified that bilastine 20 and 100 mg administered during ...
... was approved in Canada in 1972, but did not receive approval by the U.S. Food and Drug Administration (FDA) for type ... Dipeptidyl peptidase-4 inhibitors inhibit dipeptidyl peptidase-4 and thus reduce glucagon and blood glucose levels. DPP-4 ... Tilley J, Grimsby J, Erickson S, Berthel S (2010). "Diabetes Drugs: Present and Emerging". Burger's Medicinal Chemistry and ... "Questions and Answers about the Seizure of Paxil CR and Avandamet" (Press release). U.S. Food and Drug Administration. 4 March ...
In 2020, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive ... Taking the drug together with food slightly increases its concentrations in the blood, but this is not clinically relevant. ... It is an integrase inhibitor with a carbamoyl pyridone structure similar to that of dolutegravir. Cabotegravir in combination ... "FDA Approves First Extended-Release, Injectable Drug Regimen for Adults Living with HIV". U.S. Food and Drug Administration ( ...
Hui-Hua Chang; Emmanuelle J Meuillet (2011). "Identification and development of mPGES-1 inhibitors: where we are at?". Future ... Food Research. 51 (12): 1447-51. doi:10.1002/mnfr.200700144. PMID 17979097. Seo T, Tatsuguchi A, Shinji S, Yonezawa M, Mitsui K ... Medicinal Chemistry Letters. 24 (16): 3826-34. doi:10.1016/j.bmcl.2014.06.061. PMID 25027933. Jongthawin J, Chusorn P, Techasen ... Mol Nutr Food Res. 51 (12): 1447-51. doi:10.1002/mnfr.200700144. PMID 17979097. Wilhelms DB, Kirilov M, Mirrasekhian E, ...
... and as a ligand and inhibitor of α2-macroglobulin. The pharmacokinetics of bicalutamide are unaffected by food, age, body ... Lemke TL, Williams DA (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1372-1373 ... A study found that a combination of bicalutamide and dutasteride, a 5α-reductase inhibitor and inhibitor of neurosteroid ... Bicalutamide, as well as enzalutamide, have been found to act as inhibitors of P-glycoprotein efflux and ATPase activity. This ...
Foods like sashimi became daily fare, and so too did sashimi garnishes like green shiso. The word ōba was originally a trade ... Medicinal and aromatic plants--industrial profiles, 2, CRC Press, ISBN 978-90-5702-171-8, pp. 26-7 (Japanese dictionaries) ... "Two new prenylated 3-benzoxepin derivatives as cyclooxygenase inhibitors from Perilla frutescens var. acuta". J. Nat. Prod. 63 ... The word yukari is an ancient term for the color purple, and was first used by Mishima Foods Co. to describe their shiso ...
Lowe, Derek (21 June 2013). "Eight Toxic Foods: A Little Chemical Education". In the Pipeline., "Eight Toxic Foods: The ... He serves on the editorial board of ACS Medicinal Chemistry Letters and on the advisory board of Chemical & Engineering News. ... 21 June 2004). "In vitro SAR of (5-(2H)-isoxazolonyl) ureas, potent inhibitors of hormone-sensitive lipase". Bioorganic & ... "Foods Ingredients Banned Outside the US". ABC News. 26 June 2013. Nosowitz, Dan (June 21, 2013). "Chemist Says BuzzFeeᴅ Article ...
There is also a formation of harmane (an MAO inhibitor) from the acetaldehyde in tobacco smoke. This may play a role in ... "A bill to protect the public health by providing the Food and Drug Administration with certain authority to regulate tobacco ... to deliver the medicinal eugenol of cloves to the lungs. The quality and variety of tobacco play an important role in kretek ... Food Chem. Toxicol. 49 (11): 2921-33. doi:10.1016/j.fct.2011.07.019. PMID 21802474. Liu XY, Zhu MX, Xie JP (2010). " ...
Journal of Medicinal Food. 11 (4): 643-51. doi:10.1089/jmf.2007.0629. PMID 19053855.. ... In particular, the following foods contain significant inhibitors and have been suggested as part of a healthy diet for this ... Angiogenesis Inhibitors for Cancer - from The Angiogenesis Foundation, 23 June 2009. *Angiogenesis Inhibitors for Eye Disease ... In animal studies, high doses of inhibitors were required to prevent tumor growth and the use of endogenous inhibitors would ...
These foods may help prevent cancer and promote general health. Learn more about the best cancer-fighting foods here. ... Cancer-fighting foods include apples, berries, and fatty fish. ... Li, Y., & Seto, E. (2016, October). HDACs and HDAC inhibitors ... Journal of Medicinal Food, 17(12), 1281-1286. Retrieved from ... No foods protect people against cancer completely. The term cancer-fighting foods refers to foods that may lower the risk of ...
... were found to be significantly lower than the standard acarbose suggesting the presence of potential α-glucosidase inhibitors. ... Yin, Z.; Zhang, W.; Feng, F.; Zhang, Y.; Kang, W. α-Glucosidase inhibitors isolated from medicinal plants. Food Sci. Hum. ... Food Chem. 2008, 56, 8206-8211. [Google Scholar] [CrossRef] [PubMed]. *Yu, Y.; Gao, H.; Tang, Z.; Song, X.; Wu, L. Several ... Food Chem. 2012, 135, 1929-1937. [Google Scholar] [CrossRef] [PubMed]. *Jabeen, B.; Riaz, N.; Saleem, M.; Naveed, M.A.; Ashraf ...
The purpose of the study was to emphasize the effects of the association between the renin inhibitor and the polyphenolic ... renin inhibitor). The combination between the Aliskiren and polyphenolic extract produce superior hypolipidemic and antioxidant ... epidemiological studies have shown an inverse association between the consumption of polyphenols or polyphenol-rich foods and ... Journal of Medicinal Food, 13, 255-269. doi:10.1089/jmf.2009.0062 [11] Naruszewicz, M., Laniewska, I., Millo, B. and ...
Journal of Medicinal Food, 2: 149-153, 1999.35. Salti GI, Das Gupta TK, Constantinou AI. A novel use for the comet assay; ... 9. Ganapathi R, Kamath N, Constantinou AI, Grabowski D, Ford J, Anderson A. Effect of the calmodulin inhibitor trifluoperazine ... Journal of Medicinal Food, 2: 149-153, 1999.35. Salti GI, Das Gupta TK, Constantinou AI. A novel use for the comet assay; ... Food Chem. 49: 2472-2479, 2001.. 42. Constantinou AI, Lantvit D, Hawthorn M, Xu X, van Breemen R, Pezzuto J. Chemopreventive ...
In 1987, the first drug for the treatment of HIV infection was approved by the U.S. Food and Drug Administration (FDA). This ... Part 1: From alpha-anilinophenylacetamide (alpha-APA) to imidoyl thiourea (ITU)". Bioorganic & Medicinal Chemistry Letters. 11 ... Antiretroviral drug Reverse-transcriptase inhibitor Protease inhibitor Entry inhibitor Discovery and development of HIV- ... Inhibitor flexibility may not affect the inhibitor-target interactions. The NNRTIs act by binding non-competitively to the RT ...
Greiner, R., & Konietzny, U. (2006). Phytase for food application. Food Technology and Biotechnology, 44(2), 125-140.Google ... Mini-Reviews in Medicinal Chemistry, 13(3), 408-430.PubMedGoogle Scholar ... Gülçin, I., & Beydemir, Ş (2013). Phenolic compounds as antioxidants: Carbonic anhydrase isoenzymes inhibitors. ... International Journal of Food Microbiology, 87, 259-270.CrossRefPubMedGoogle Scholar ...
It is a spicy plant widely used as food and herbal medicine in the South and Southeast Asian countries. The study evaluated ... Nam NH (2006). Naturally occurring NF-kappaB inhibitors. Mini-Reviews in Medical Biochemistry 6(8):945-951.. Crossref ... It is a spicy plant of pepper family which is widely used as food and herbal medicine in South and Southeast Asian countries. ... It is a spicy plant widely used as food and herbal medicine in the South and Southeast Asian countries. The study evaluated ...
K. Yoshikawa, T. Murakami, and H. Matsuda, "Medicinal food stuffs. IX. The inhibitors of glucose absorption from the leaves of ... M. Yoshikawa, T. Murakami, M. Kadoya et al., "Medicinal foodstuffs. IX. The inhibitors of glucose absorption from the leaves of ... V. K. Singh, S. Umar, S. A. Ansari, and M. Iqbal, "Gymnema sylvestre for diabetics," Journal of Herbs, Spices and Medicinal ... Among the medicinal plants, G. sylvestre is a herb less exploited for its innumerable advantages. The aim of this review is to ...
James Duke shares information on COX-2 inhibitors and urges homesteaders to grow vegetables to fight cancer and pain naturally. ... Journal of Medicinal Foods 1, no. 4 (1999): 293-98.. L.M. Posey. "Safety of COX 2 Inhibitors Explored at Digestive Disease Week ... There are plenty of natural COX-2 inhibitors out there, contained in any number of well-known anti-inflammatory food plants or ... COX-2 Inhibitors can ease pain and fight cancer - naturally.. NOTE: Vioxx, mentioned in this article, was withdrawn in 2004 due ...
p53-Induced Apoptosis and Inhibitors of p53. Current Medicinal Chemistry. *Cratylia mollis Lectin: A Versatile Tool for ... Current Nutrition & Food Science. * "Cancer Antigen WT1 Protein-Derived Peptide"-Based Treatment of Cancer -Toward the Further ... Copeland, R.A.; Harpel, M.R.; Tummino, P.J. Targeting enzyme inhibitors in drug discovery. Expert Opin. Ther. Targets, 2007, 11 ... Current Medicinal Chemistry. * Targeting Transcription: A New Concept of Anti-Inflammatory Therapy of Airway Diseases. Current ...
Since there is a variety of plants that serve as food sources in Malaysia that have yet to be tested for anti-QS activity, ... Piper betle and Gnetum gnemon are used as food sources by Malaysians. The purpose of this study is to examine the anti-quorum ... Khee, H.K.; Foong-Yee, T. Screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity. J. ... These plants serve not only as foods, but they are also used as medicinal plants, although little is known about the anti-QS ...
Mushrooms and truffles are highly desirable foods; yeast is essential for baking, brewing, and fermenting; and molds flavor and ... Fungi also have beneficial medicinal and culinary attributes. They were used in traditional medicine long before Alexander ... They have subsequently been used to develop antibiotics, fungicides, anticancer drugs, and cholesterol inhibitors. ... and biofilm inhibitors. Ubiquitous and unique, fungi have a fascinating array of yet unexplored uses. ...
ZYTIGA is an inhibitor of CYP2C8 (in vitro data); Medicinal products metabolised by CYP2C8 include paclitaxel and repaglinide. ... It must not be taken with food as this increases systemic exposure to abiraterone (take dose at least two hours after eating; ... ZYTIGA® in combination with prednisone was approved by the U.S. Food and Drug Administration (FDA) in April 2011 for the ... ZYTIGA is CYP3A4 substrate (in vitro data); avoid or use with caution with strong CYP3A4 inhibitors (e.g. ketoconazole, ...
September 2015). "Design, synthesis and biological characterization of selective LIMK inhibitors". Bioorganic & Medicinal ... Fasudil, not currently approved by the U.S. Food and Drug Administration (FDA), but in Japan and China it is used for ... Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho ... Rho kinase inhibitor also functions by blocking rho-mediated dephosphorylation of MLC20. A number of Rho kinase inhibitors are ...
Adriana L. Perales-Torres, Rubén Santiago-Adame and Martha B. Ramírez Rosas, Food Safety Department, Autonomous University of ... Inhibitors, metabolic disorders, peptides ... Home / Shop / Imprints / Nova Medicine and Health / Medicinal ... Medicinal Plants for the Treatment of Metabolic Disorders. Part 1. $270.00. Anaberta Cardador-Martínez (Editor). Escuela de ... Use of Medicinal Plants for the Treatment of Parkinsons Disease: A Brief Review. (Karla I. Zepeda-Chong, Darlenne A. Juarez- ...
Inhibitors that are in current clinical use include anastrozole, exemestane, and letrozole. Aromatase inhibitors are also ... Food and Chemical Toxicology. 40 (7): 925-33. doi:10.1016/S0278-6915(02)00066-2. PMID 12065214. Kapiszewska M, Miskiewicz M, ... Anti-Cancer Agents in Medicinal Chemistry. 8 (6): 646-82. doi:10.2174/1871520610808060646. PMC 3074486. PMID 18690828. Satoh K ... "Aromatase Inhibitors". Attar E, Bulun SE (May 2006). "Aromatase inhibitors: the next generation of ...
European Journal of Medicinal Chemistry" on DeepDyve, the largest online rental service for scholarly research with thousands ... "An overview of natural antimicrobials role in food, ... Antimicrobial peptides: pore formers or metabolic inhibitors in ... Bioactivity of medicinal plant extracts against Listeria monocytogenes isolated from food. Pirbalouti, A.G.; Chaleshtori, A.R ... An overview of natural antimicrobials role in food. An overview of natural antimicrobials role in food Pisoschi, Aurelia ...
Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes. ... Therefore, inducers or inhibitors of CYP3A4 may affect the progestogen drug metabolism.. An increased clearance of sex hormones ... Effects of Visanne on other medicinal products.. Based on in vitro inhibition studies, a clinically relevant interaction of ... These medicines/foods may be affected by Visanne, or may affect how well it works. Your doctor may need to alter the dose of ...
Effects of other medicinal products on simvastatin. Interactions involving inhibitors of CYP3A4. Simvastatin is a substrate of ... inhibitors is reached approximately 1-2 hours after administration of simvastatin.. Concomitant food intake does not affect the ... Concomitant administration of potent CYP3A4 inhibitors (e.g. itraconazole,. ketoconazole, posaconazole, HIV protease inhibitors ... during the initial months of therapy and when the dose of either medicinal product is. increased.. ≥. In an interim analysis of ...
Food Chem Toxicol. 2002;40(11):1669-1675.12176092. 36. Azumi S, Tanimura A, Tanamoto K. A novel inhibitor of bacterial ... Ernst E. Herbal medicinal products during pregnancy: are they safe? BJOG. 2002;109(3):227-235.11950176. ... Cinnamaldehyde content in foods determined by gas chromatography-mass spectrometry. J Agric Food Chem. 2000;48(11):5702- ... Cinnamon is generally recognized as safe when used as food. Avoid dosages above those found in food because safety and efficacy ...
Gurib-Fakim A (2006) Medicinal plants: traditions of yesterday and drugs of tomorrow. Mol Asp Med 27:1-93CrossRefGoogle Scholar ... Bhandarkar SS, Arbiser JL (2007) Curcumin as an inhibitor of angiogenesis. Adv Exp Med Biol 595:185-195CrossRefGoogle Scholar ... "functional food" in the field of food chemistry and as "preventive medicine" in the field of pharmacology and healthcare. ... Curcumin Functional food Anticancer Antioxidant Diabetes Cardiomyopathy This is a preview of subscription content, log in to ...
Oncogene signal transduction inhibitors from medicinal plants. In Vivo 1996;10:185-190. ... As a result, food may not remain in the intestine long enough for the body to absorb minerals such as potassium. This can lead ... As a result, food may not remain in the intestine long enough for the body to absorb minerals such as potassium. This can lead ... As a result, food may not remain in the intestine long enough for the body to absorb minerals such as potassium. This can lead ...
Food., 2011 Search PubMed (in press).. *I. K. Lee, Y. S. Kim, Y. W. Jang, J. Y. Jung and B. S. Yun, New antioxidant polyphenols ... Y. Ren, P. J. Houghton, R. C. Hider and M. L. Howes, Novel diterpenoid acetylcholinesterase inhibitors from, Salvia miltiorhiz ... J. Food Sci. Nutr., 2009, 60, 175-184 CrossRef CAS.. *C. A. Barnes, W. Danysz and C. G. Parsons, Effects of the uncompetitive ... Food Res., 2009, 53, 1386-1395 CrossRef CAS.. *V. V. Giridharan, R. A. Thandavarayan, S. Sato, K. M. Ko and T. Konishi, ...
Recent Researches in Triazole Compounds as Medicinal Drugs. Current Medicinal Chemistry. *Three Decades of P-gp Inhibitors: ... Food Proteins as Source of Opioid Peptides-A Review. Current Medicinal Chemistry ... Immune Checkpoint Inhibitors: Basics and Challenges Current Medicinal Chemistry. *Peptide Deformylase: A New Target in ... Current Medicinal Chemistry. *Fragment Based Drug Design: From Experimental to Computational Approaches. Current Medicinal ...
COX inhibitor screening assay showed TP as a selective inhibitor of COX-2 enzyme. Conclusions The anti-inflammatory effects of ... According to the Food and Drug Administration of the USA, during 1983-2010, over 1,000 kinds of small-molecule substances were ... Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances. Mutat Res (1999) 428(1): ... COX inhibitor screening assay showed TP as a selective inhibitor of COX-2 enzyme. ...
... a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), is approved in the US, EU, and other regions for the treatment ... Effect of Food. The effect of food on the PK of the maximum approved strength of ertugliflozin (15 mg) was evaluated in an open ... European Medicines Agency; Committee for Medicinal Products for Human Use. Steglatro™ (ertugliflozin): European public ... Table 1 Summary of SGLT2 inhibitors currently approved for use in the US and EU and their relative selectivity [9, 26, 59]. ...
Wang SL (Invited speaker) Human saliva alpha-amylase inhibitors from a Vietnamese medicinal plant. The 5th KIST-OPU-ECUST-TKU ... Food Chemistry, 119:1380-1385. SCI. *Wang SL*, Li JY, Liang TW (2010) Conversion of shrimp shell by using Serratia sp. TKU017 ... Nguyen VB, Nguyen QV, Nguyen AD, Wang SL* (2017) Screening and evaluation of α-glucosidase inhibitors from indigenous medicinal ... Wang SL (Invited speaker) Enzyme inhibitors from Vietnamese medicinal plants. 3rd OPU-TKU International Symposium, Osaka ...
Food Chem Toxicol. 42(9):1513-29, 2004. Review.. *Thom E. The effect of chlorogenic acid enriched coffee on glucose absorption ... Journal of Medicinal Chemistry. 40(2): 137-145, 1997.. *Henry-Vitract, C., et al. Contribution of Chlorogenic Acids to the ... Chlorogenic acid and synthetic chlorogenic acid derivatives: novel inhibitors of hepatic glucose-6-phosphate translocase. ... These statements have not been evaluated by the Food and Drug Administration.. This product(s) is not intended to diagnose, ...
  • Rho-kinase inhibitors (rho-associated protein kinase inhibitor or ROCK inhibitor) are a series of compounds that target rho kinase (ROCK) and inhibit the ROCK pathway. (
  • Phenolic compounds as antioxidants: Carbonic anhydrase isoenzymes inhibitors. (
  • Natural preservatives could also constitute a viable alternative to address the critical problem of microbial resistance, and to hamper the negative side effects of some synthetic compounds, while meeting the requirements for food safety, and exerting no negative impact on nutritional and sensory attributes of foodstuffs. (
  • The importance of bioactive compounds present in natural sources has withdrawn ample attention in human nutrition and established as "functional food" in the field of food chemistry and as "preventive medicine" in the field of pharmacology and healthcare. (
  • Kris-Etherton PM, Hecker KD, Bonanome A et al (2002) Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. (
  • For example, a study published in the Journal of Medicinal Food resports that olive leaf compounds prevent the formation of advanced glycation end products (AGEs), substances that are responsible for the development of complications in diabetes, such as diabetic neuropathy. (
  • Many plants and plant foods, including vegetables and legumes, contain amylase-inhibiting compounds that may be useful in preventing and treating type 2 diabetes. (
  • Another anti-inflammatory group of compounds which can be obtained from foods are anthocyanins, thats what my PhD thesis research actually focuses on. (
  • I'll skip the mindnumbing detail, but the blue/purple compounds which give the bright colors to blueberries, blackberries, red cabbage, etc are also great functional foods for combating inflammation. (
  • Rho kinase inhibitor also functions by blocking rho-mediated dephosphorylation of MLC20. (
  • In an oral presentation entitled "Histone deacetylase inhibitor romidepsin enhances anti-tumor effect of erlotinib in non-small cell lung cancer (NSCLC) cell lines" Dr. Zhang showed data from a preclinical study designed to examine the effect of the histone deacetylase (HDAC) inhibitor romidepsin in combination with the tyrosine kinase inhibitor (TKI) erlotinib in NSCLC. (
  • The Company's lead product, MGCD0103, is an oral isotype-selective HDAC inhibitor presently in multiple clinical trials for solid tumors and hematological malignancies, including Phase II monotherapy and Phase I and Phase II combination trials with Vidaza(R), Gemzar(R) and Taxotere(R). MGCD265 is an oral kinase inhibitor targeting the c-Met, Tie-2, Ron and VEGF receptor tyrosine kinases. (
  • CytRx Chief Medical Officer Daniel Levitt, MD, Ph.D., stated, "Bafetinib is a dual protein kinase inhibitor targeting both Bcr/Abl and Lyn kinases. (
  • Bafetinib is a potent, orally available, rationally designed, dual Bcr-Abl and Lyn kinase inhibitor, which was developed as a third-line treatment for patients with CML and certain forms of acute myeloid leukemia (AML) that are refractory or intolerant of other approved treatments. (
  • Mini-Reviews in Medicinal Chemistry, 13 (3), 408-430. (
  • However medicinal chemistry offers solutions to the first two limitations and oral bioavailability issues have been addressed with novel routes of administration (e.g. intranasal, inhalation) and injectable depot formulations. (
  • Medicinal chemistry approaches here have been peptide modifications to slow release from the injection site (hydrophobic, hydrophilic, selfassociating depots), PEGylation, fatty acid acylation, and the like. (
  • Medicinal chemistry approaches used in successful peptide pharmaceuticals using unnatural amino acids to achieve depot formation are highlighted in this review. (
  • J. J. Nestor Jr., " The Medicinal Chemistry of Peptides", Current Medicinal Chemistry (2009) 16: 4399. (
  • Novel Chalcone Derivatives as Potent Nrf2 Activators in Mice and Human Lung Epithelial Cells," Journal of medicinal Chemistry, 54(12), 4147-4159 (May 3, 2011). (
  • Antiproliferative activity of chalcones with basic functionalities," Bioorganic Y& Medicinal Chemistry, 15(22), 7021-7034 (Sep. (
  • Anti-invasive Activity of Alkaloids and Polyphenolics in Vitro," Bioorganic & Medicinal Chemistry, 5(8), 1609-1619 (Jan. 1, 1997). (
  • Medicinal Chemistry is a recognised strength of Newcastle University. (
  • The academic team work across a number of complementary themes across the Medicinal Chemistry and Chemical Biology research area. (
  • This important new book provides innovative material, including peer-reviewed chapters and survey articles on new applied research and development, in the scientifically important field of QSAR in medicinal chemistry. (
  • Current Medicinal Chemistry (2007) 14: 2831. (
  • Vicuron's versatile research engine integrates industry-leading expertise in functional genomics, natural products discovery, mechanism-based drug design and combinatorial and medicinal chemistry. (
  • Studies on substituted traizine and traizole derivatives as corrosion inhibitors for mild steel, copper, brass and aluminium in acid solutions" under the Principal Investigatorship of Dr. Abraham Joseph, Reader, Department of Chemistry. (
  • In the present study, the tyrosinase inhibitory properties of 50 medicinal plant extracts from Peru were investigated using tyrosinase assay. (
  • 5 Varying sources of material and extraction techniques alter the chemical composition of the extracts, and may impact the intended medicinal and experimental effects. (
  • Polyphenols are important components of plant extracts as well as being consumed in food as dietary polyphenols. (
  • The current study was designed to evaluate silver nanoparticles (AgNPs) fabricated using aqueous extracts of two medicinal plants, Anastatica hierochuntica L. (Kaff Maryam) and Artemisia absinthium . (
  • Olive leaf extracts are a natural source of advanced glycation end product inhibitors. (
  • In this paper, DPPH method has been applied to the bark extracts of the selected medicinal plants. (
  • This method presents the advantage of using stable and commercially available free radical and has been extensively applied on plant extracts and on various food materials [ 13 , 14 ]. (
  • have several phytochemicals and extracts which have potential use as medicinal food, nutraceutical, or functional vegetables in the United States and other countries worldwide. (
  • While some food and herbal extracts with amylase-inhibiting effects have shown promise in animal research, their benefits for type 1 diabetes await confirmation in clinical trials. (
  • This is why scientists are studying natural extracts from over 400 traditional medicinal plants with alpha-amylase blocking activity for their exciting potential as effective, and likely safer, antidiabetic therapies. (
  • Results suggests that extracts of Linum usitatisumum , Morus alba and Ocimum tenuiflorum act effectively as PPA inhibitors leading to a reduction in starch hydrolysis and hence eventually to lowered glucose levels. (
  • Plants are naturally potential sources of medicinal agents nowadays. (
  • Plants possessing antidiabetic activities are of significant interest for ethnobotanical community as they are recognized to contain valuable medicinal properties in different parts and a number of them have shown varying degree of hypoglycemic and antihyperglycemic activity [ 1 ]. (
  • Peru is a diverse country with a wide variety of plants that may contain excellent anti-tyrosinase inhibitors. (
  • Medicinal Plants for the Treatment of Metabolic Disorders. (
  • Home / Shop / Imprints / Nova Medicine and Health / Medicinal Plants for the Treatment of Metabolic Disorders. (
  • Medicinal plants used in traditional medicine for treatment and scientific information related to their potential to prevent or treat each conditions are also discussed. (
  • 33 In vitro experimentation was conducted in H. pylori-infected gastric epithelial cells with 24 medicinal plants indigenous to Pakistan to evaluate their effect on secretion of interleukin (IL)-8 and generation of reactive oxygen species (ROS) in order to assess anti-inflammatory and cytoprotective effects. (
  • Balunas MJ, Kinghorn AD (2005) Drug discovery from medicinal plants. (
  • Stem barks derived from twenty-one medicinal plants were extracted in methanol (100%) and acetone-water (70 : 30 v/v) and at room as well as at reflux temperature conditions. (
  • The antioxidant constituents of plants are gaining the interest of scientists and food manufactures because the future demand is functional food with specific health effects. (
  • However, there are medicinal plants with anti-inflammatory therapeutic effects with low or no side effects. (
  • The African continent is richly endowed with diverse medicinal plants with anti-inflammatory activities that have been shown to be effective in the treatment of inflammatory conditions in traditional medicine. (
  • Interestingly, scientists have examined some of these African medicinal plants and documented their biological and therapeutic activities. (
  • Unfortunately, medicinal plants from different countries in Africa with anti-inflammatory properties have not been documented in a single review paper. (
  • It is important to document the ethnobotanical knowledge and applications of anti-inflammatory medicinal plants from selected countries representing different regions of the African continent. (
  • This paper therefore documents anti-inflammatory activities of various medicinal plants from different geographical regions of Africa with the aim of presenting the diversity of medicinal plants that are of traditional or therapeutic use in Africa. (
  • The objective of this study was to present a review of several legume species in the USDA, ARS, Plant Genetic Resources Conservation Unit's (PGRCU) collection for potential use as non-traditional human medicinal plants. (
  • In conclusion, the medicinal plants Urtica dioica and Juglans regia may have potential as antidiabetic therapies. (
  • Indian medicinal plants used in the Ayurvedic traditional system to treat diabetes are a valuable source of novel anti-diabetic agents. (
  • In this study, seventeen Indian medicinal plants with known hypoglycemic properties were subjected to sequential solvent extraction and tested for α-amylase inhibition, in order to assess and evaluate their inhibitory potential on PPA (porcine pancreatic α-amylase). (
  • COX inhibitor screening assay showed TP as a selective inhibitor of COX-2 enzyme. (
  • Ertugliflozin, a selective inhibitor of sodium-glucose cotransporter 2 (SGLT2), is approved in the US, EU, and other regions for the treatment of adults with type 2 diabetes mellitus (T2DM). (
  • Pimasertib (AS703026 or MSC1936369B) is a selective inhibitor of MEK1/2, the mitogen-activated protein kinase (MAPK) signaling pathway, which is often dysregulated in cancer cells. (
  • Alexion Pharmaceuticals, Inc. has announced today that Soliris® (eculizumab), its first-in-class complement inhibitor, has been granted Orphan Medicinal Product Designation by the European Commission for the treatment of patients with atypical Hemolytic Uremic Syndrome (aHUS). (
  • Orphan Medicinal Product Designation allows special incentives forspo. (
  • Orphan Medicinal Product Designation allows special incentives for sponsors planning to test a product for use in a rare disease or condition generally characterized by a small number of patients. (
  • The development of NNRTIs improved quickly into the 1990s and they soon became the third class of antiretroviral drugs, following the protease inhibitors. (
  • Romidepsin is a novel agent in a new class of anti-cancer drugs known as histone deacetylase inhibitors. (
  • PHRM ) and MethylGene Inc. (TSX: MYG) today announced that the European Medicines Agency (EMEA) and the European Commission (EC) designated MGCD0103, a histone deacetylase (HDAC) inhibitor, as an Orphan Medicinal Product for the treatment of acute myelogenous leukemia in the European Union (EU). (
  • Strategies to inhibit the VEGF pathway include antibodies directed against VEGF or VEGFR, soluble VEGFR/VEGFR hybrids, and tyrosine kinase inhibitors. (
  • In November 2008, CytRx announced that bafetinib demonstrated clinical responses in patients with CML in an international, open-label Phase 1 dose-ranging clinical trial conducted in patients with CML and other leukemias that have a certain mutation called the Philadelphia Chromosome (Ph+) and are intolerant of or resistant to Gleevec ® and, in some cases, second-line tyrosine kinase inhibitors such as dasatinib and nilotinib. (
  • [4] [5] The most widely used VEGF pathway inhibitor on the market today is Bevacizumab . (
  • HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase is the key enzyme in the cholesterol biosynthesis pathway, and the statin-like drugs are inhibitors of human HMG-CoA reductase (hHMGR). (
  • JAK inhibitors act on the JAK pathway by working inside the cell to disrupt a signaling pathway believed to play a role in the inflammation associated with moderately to severely active RA. (
  • The PI3K/AKT pathway has a natural inhibitor called PTEN whose function is to limit proliferation in cells, helping to prevent cancer. (
  • Most of the current therapeutic drugs available in clinical utilization function as enzyme inhibitors. (
  • RKI-1447, a potent small molecule inhibitor of ROCK1 and ROCK2. (
  • 17 The medicinal mushroom also produces various classes of secondary metabolites with potent anti-oxidant activity. (
  • Curcumin has an extensive history as a food additive and herbal medicine in India and is also a potent polyphenolic antioxidant. (
  • Phytic acid (IP6) is a potent antioxidant present in several natural foods. (
  • The multidrug, single- or multiple-target therapies have revived the development of new and more potent RT inhibitors. (
  • It is a potent inhibitor of various mutant viral variants that have emerged. (
  • They have subsequently been used to develop antibiotics, fungicides, anticancer drugs, and cholesterol inhibitors. (
  • Molecular Mechanism: Rho kinase inhibitors act on Rho kinase by altering the conformation of the protein, disrupting translocation to the plasma membrane, preventing ATP-dependent phosphorylation, and blocking RhoA binding to ROCK. (
  • Consistent with the mechanism of action of SGLT2 inhibitors, 24-h urinary glucose excretion decreased with worsening renal function. (
  • The peptide deformylase inhibitor class of antibiotics targets a novel protein that is essential for bacterial growth and provides the basis for selective activity toward a wide range of bacterial pathogens. (
  • Unlike the Asian culture, where people eat small amounts of whole non-GMO soybean products, western food processors separate the soybean into two golden commodities-protein and oil. (
  • As regular readers of the my articles are aware, whey protein appears to function as a natural food against cancer, HIV, overtraining syndrome in athletes and a host of pathologies. (
  • Amylase inhibitors from various medicinal herbs and plant foods may reduce the usual after-meal rise in blood glucose levels in people with diabetes. (
  • Some angiogenesis inhibitors are endogenous and a normal part of the body's control and others are obtained exogenously through pharmaceutical drugs or diet . (
  • Non-nucleoside reverse-transcriptase inhibitors (NNRTIs) are antiretroviral drugs used in the treatment of human immunodeficiency virus (HIV). (
  • There are two classes of drugs that target the HIV-1 RT enzyme, nucleoside/nucleotide reverse-transcriptase inhibitors (NRTIs/NtRTIs) and non-nucleoside reverse-transcriptase inhibitors (NNRTIs). (
  • Although dietary supplements are regulated by the FDA as foods, their regulation differs from drugs and other foods. (
  • Some popular drugs considered as cox1 and cox2 inhibitors are non-steroidal Anti-inflammatory drugs, such as aspirin, ibuprofen, and naproxen. (
  • As many glycerides were widely used in foods, cosmetics and drugs, a variety of analyses in vivo and in vitro usually need to be performed. (
  • Newcastle discovered the first PARP inhibitors for the treatment of BRCA deficient cancer. (
  • ATARI trial tests the ATR inhibitor drug AZD6738 and a PARP inhibitor drug olaparib in patients with relapsed gynecological cancers to assess the response in groups of patients selected based on their cancer cell subtype and the presence of an abnormality in ARID1A gene. (
  • MGCD0103 is an orally-administered isotype-selective HDAC inhibitor. (
  • In addition, MethylGene's preclinical programs include: MGCD290 an HDAC inhibitor in combination with azoles for fungal infections and a sirtuins program for cancer. (
  • AT-13148 BA-210 β-Elemene DJ4, which is a selective multi-specific ATP competitive inhibitor of activity of ROCK1 (IC50 of 5 nM), ROCK2 (IC50 of 50 nM), MRCKα (IC50 of 10 nM) and MRCKβ (IC50 of 100 nM) kinases without affecting activity of PAK1 and DMPK at 5 μM concentrations in in vitro cell-free kinase activity assays. (
  • Mushrooms are a nutritionally functional food and a source of physiologically beneficial medicines. (
  • The ability of phlorotannins to mediate hyperglycaemia and hyperlipidaemia makes them attractive candidates for the development of functional food products to reduce the risk of cardiovascular diseases and type 2 diabetes. (
  • Lastly, this chapter will examine the potential of marine algae and their polyphenols to be produced into functional food products through investigating safe levels of polyphenol consumption, processing techniques, the benefits of farming marine algae, and the commercial potential of marine functional products. (
  • Most often they are grouped in the following categories: dietary supplements, functional food, medicinal food, farmaceuticals. (
  • According to their generally accepted definition, functional food is a category which includes whole foods and fortified, enriched or enhanced dietary components that may reduce the risk of chronic disease and provide a health-benefit beyond the traditional nutrients it contains. (
  • These species could provide the medicinal, nutraceutical, and functional food industries with valuable health products and can be used by other scientist's and breeders for the development of unique germplasm and/or advanced cultivars with one or more of these traits. (
  • Their book introduces readers to the concept that the COX-2-Is found in nature, in such medicinal herbs as ginger and turmeric, can spare a great deal of pain and many fatalities. (
  • Amylase inhibitors occur naturally in foods such as whole grains and legumes, as well as in many culinary herbs and spices and medicinal herbs, possibly contributing to their anti-diabetic effects. (
  • By Akanksha, Pharmacology Correspondent, Vicuron Pharmaceuticals Inc. announced today that the company has received another milestone payment from Novartis Pharma AG in recognition of follow-up lead product candidates identified for Novartis' development from its ongoing research collaboration focused on peptide deformylase inhibitors, a novel class of antibiotics. (
  • Peptide deformylase inhibitors constitute one of the most promising new antibiotic classes and hold the potential to treat large markets of community bacterial infections. (
  • Amylase inhibitors are also known as starch blockers because they contain substances that prevent dietary starches from being absorbed by the body. (
  • 3 , 4 , 5 , 6 Later, however, highly concentrated versions of amylase inhibitors did show potential for reducing carbohydrate absorption in humans. (
  • Amylase inhibitors contain substances that prevent dietary carbohydrates from being absorbed by the body and may aid in weight loss. (
  • Amylase inhibitors, taken with meals, may reduce the usual rise in blood sugar levels in people with diabetes. (
  • Amylase inhibitors are substances that reduce the activity of amylase, the digestive enzyme required to break down dietary starches into absorbable glucose. (
  • Depending on the potency of the amylase inhibitors , typical intake is 1,500 to 6,000 mg before meals. (
  • In fact, 'alpha-amylase inhibitors' have been developed to treat diabetes in this way. (
  • While currently available alpha-amylase inhibitors do provide short-term diabetes control, they also cause serious side effects. (
  • Pancreatic α-amylase inhibitors offer an effective strategy to lower the levels of post-prandial hyperglycemia via control of starch breakdown. (
  • Unripe fruits are astringent and contain trypsin inhibitors. (
  • If jackfruit is ingested raw, trypsin is inhibited, so that the body can not digest food and may suffer from stomach pain , nausea, vomiting or diarrhea . (
  • Cooking destroys trypsin inhibitors, so they eat jackfruit boiled or cooked with coconut milk and curry). (
  • An angiogenesis inhibitor is a substance that inhibits the growth of new blood vessels ( angiogenesis ). (
  • Angiogenesis inhibitors were once thought to have potential as a " silver bullet " treatment applicable to many types of cancer , but the limitations of anti-angiogenic therapy have been shown in practice. (
  • Angiogenesis is regulated by the activity of endogenous stimulators and inhibitors. (
  • During tumor growth, the action of angiogenesis stimulators surpasses the control of angiogenesis inhibitors, allowing for unregulated or less regulated blood vessel growth and formation. (
  • Some studies suggest that Rho kinase inhibitors also play a role in anti-angiogenesis by blocking ERK and Akt signaling pathways. (
  • Bhandarkar SS, Arbiser JL (2007) Curcumin as an inhibitor of angiogenesis. (
  • Drug survival on tumour necrosis factor inhibitors in patients with rheumatoid arthritis in Finland. (
  • Efficacy and effectiveness of tumour necrosis factor inhibitors in the treatment of rheumatoid arthritis in randomized controlled trials and routine clinical practice. (
  • Personally, Ive seen remarkable benefits of eating fish ( oil ) and anthocyanin-rich foods in a few clients with rheumatoid arthritis. (
  • In addition, the European Agency for the Evaluation of Medicinal Products (EMEA) has issued Orphan Drug status for the treatment of both CTCL and PTCL. (
  • MGCD0103 has received orphan drug designation from the U.S. Food and Drug Administration (FDA) for the treatment of Hodgkin lymphoma and has been designated an Orphan Medicinal Product by the EMEA for the treatment of Hodgkin lymphoma and acute myelogenous leukemia. (
  • In April 2010, the Company announced that bafetinib had received official notification from the Committee for Orphan Medicinal Products (COMP) of the European Medicines Agency (EMEA) that a positive opinion was made regarding the application for orphan medicinal product status for the treatment of chronic myeloid leukemia (CML). (
  • Romidepsin has received Orphan Drug Designation from the Food and Drug Administration (FDA) for the treatment of non-Hodgkin T-cell lymphomas, which includes CTCL and PTCL. (
  • The U.S. Food and Drug Administration granted orphan drug designation to Soliris for the same indication in May 2009. (
  • In the U.S., the Food and Drug Administration (FDA) has granted Breakthrough Therapy Designation in April, and Priority Review in June, for this line extension. (
  • The term "nutraceutical" combines two words - "nutrient" (a nourishing food component) and "pharmaceutical" (a medical drug). (
  • The active pharmaceutical ingredient (API) of Efavirenz Capsules 50 mg, 100 mg, and 200 mg is the non-nucleoside reverse transcriptase inhibitor efavirenz, a well established and documented active substance for the treatment of HIV/AIDS in combination with other products. (
  • AHUS is an ultra-rare, inherited, and life-threatening complement-inhibitor deficiency disease that often progresses to end-stage kidney disease or failure. (
  • In May 2018, HEMLIBRA was launched in Japan for routine prophylaxis to prevent or reduce the frequency of bleeding episodes in patients with congenital factor VIII deficiency (hemophilia A) with factor VIII inhibitors. (
  • Angioedema can be classified into at least four types, acute allergic angioedema, non-allergic drug reactions, idiopathic angioedema, hereditary angioedema (HAE) and acquired C1 inhibitor deficiency . (
  • [4] [5] However, the therapeutic use of endogenous inhibitors has disadvantages. (
  • This volume is a valuable reference for professionals involved in product development and researchers focusing on food and nutraceutical products. (
  • One study from 2018 in the Journal of Food and Drug Analysis suggests that apple phloretin significantly inhibits the growth of breast cancer cells, while not affecting normal cells. (
  • Journal of Medicinal Food, 13, 255-269. (
  • International Journal of Food Microbiology, 87 , 259-270. (
  • International Journal of Food Properties, 20 (2), 2127-2137. (
  • In a published study in the February 2010 issue of the "Journal of Ethnopharmacology" and the 2005 issue of "Journal of Medicinal Food," it was noted that ginger tea works by repressing prostaglandin synthesis through the inhibition of enzymes that cause inflammation namely cyclooxygenase-1 (Cox1) and cyclooxygenase-2 (Cox2). (
  • In their new book, Beyond Aspirin: Nature's Answer to Arthritis, Cancer & Alzheimer's Disease (Rohm Press, 2000), authors Thomas M. Newmark and Paul Schulick have become some of the first health experts to talk about the miracles of natural cyclooxygenase-2 inhibitors, better known as COX-2 inhibitors or COX-2-Is. (
  • [7] Endogenous inhibitors are attractive targets for cancer therapy because they are less toxic and less likely to lead to drug resistance than some exogenous inhibitors. (
  • Plant Foods for Human Nutrition, 59, 113-122. (
  • Metabolic and functional paths of lactic acid bacteria in plant foods: Get out of the labyrinth. (
  • It is a spicy plant widely used as food and herbal medicine in the South and Southeast Asian countries. (
  • has been widely used as a medicinal plant by Peruvians, little is known regarding its bioactive components and effects on tyrosinase activity. (
  • Abroma augusta is a well-known medicine plant with a variety of medicinal uses. (
  • Efavirenz Capsules 50 mg, 100 mg, and 200 mg, manufactured by Aurobindo Pharma Ltd., Hyderabad 500 072, India, was the subject of an abbreviated new drug application (ANDA) submitted to the U. S. Food and Drug Administration (USFDA) pursuant to section 505(j) of the U. S. Federal Food, Drug, and Cosmetic Act. (
  • Endogenous inhibitors are found in the body naturally and involved in the day-to-day process of regulating blood vessel formation. (
  • Dr. James Duke shares information on COX-2 inhibitors and urges homesteaders to grow vegetables to fight cancer and pain naturally. (
  • COX-2 Inhibitors can ease pain and fight cancer - naturally. (
  • Tyrosinase inhibitors are of far-ranging importance in cosmetics, medicinal products, and food industries. (
  • For this reason, we attempted to discover tyrosinase inhibitors in H. laricifolium Juss. (
  • That substance is identical with lovastatin, a cholesterol synthesis inhibitor which is marketed in Germany as a prescription medicinal product. (
  • Natural food nutrients can regulate cholesterol synthesis, prevent cholesterol transportation to the arteries, and reduce inflammation, which increases plaque build-up. (
  • Medicinal mushrooms, also used in Traditional Chinese medicine to promote health and longevity, lower the risk of cancer and heart disease and boost the immune system. (
  • Evaluation of selected culinary-medicinal mushrooms for antioxidant and ACE inhibitory activities. (
  • Antioxidant analysis of different types of edible mushrooms (Agaricus bisporous and Agaricus brasiliensis) Int. Food Res. (
  • Research topics include the antioxidant properties of certain products, the development of functional and medicinal beverages, nutraceuticals and functional foods for alternative therapies, and more. (
  • Mathe, Endre 2018-01-01 00:00:00 The present paper aims to review the natural food preservatives with antimicrobial properties emphasizing their importance for the future of food manufacturing and consumers' health. (
  • 5 Hence, novel AChE inhibitors from natural sources could be valuable alternatives in the context of AD treatment. (
  • Mother Nature provides natural nutrients found in common foods that can help reduce LDL cholesterol, increase HDL cholesterol, and maintain healthy liver metabolism. (
  • The present study aimed to virtually screen for potential hHMGR inhibitors from natural product to discover hypolipidemic drug candidates with fewer side effects and lesser toxicities. (
  • n -3 Fatty acids from fish and fish oil are natural food substances that prevent coronary artery disease and sudden death. (
  • In 1987, the first drug for the treatment of HIV infection was approved by the U.S. Food and Drug Administration (FDA). (
  • Currently, the treatment of AD is the administration of acetylcholinesterase (AChE) inhibitors that increase the availability of ACh at cholinergic synapses. (
  • Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a novel class of insulin-independent antihyperglycemic agents for the treatment of type 2 diabetes mellitus (T2DM). (
  • The introduction of the first oral JAK inhibitor for RA in China, XELJANZ ® , builds upon Pfizer's legacy as an innovator in inflammation and immunology and provides a new option for physicians and adult patients with moderately to severely active RA who may prefer an oral treatment for this chronic condition," said Mr. Guohong Shan, China Country Lead, Pfizer Innovative Health. (
  • In January 2017, the Committee for Medicinal Products for Human Use (CHMP) of the European Medicines Agency (EMA) adopted a positive opinion recommending XELJANZ 5 mg twice daily (BID) for the treatment of patients with moderate to severe active RA. (
  • The company has two New Drug Applications pending with the U.S. Food and Drug Administration for its lead products, dalbavancin, a novel intravenous antibiotic for the treatment of serious Gram-positive infections, and anidulafungin, a novel antifungal agent. (
  • One PDE5 inhibitor, sildenafil, has been shown to improve pulmonary haemodynamics and exercise capacity in patients with PAH and is now an approved treatment. (
  • Bafetinib also has been granted Orphan Drug Status for the treatment of Philadelphia chromosome-positive (Ph+) CML by the U.S. Food and Drug Administration (FDA). (
  • We are committed to deliver HEMLIBRA which has been created with our proprietary bispecific antibody technologies, as a new treatment option to people with hemophilia A without inhibitors as early as possible in cooperation with Roche. (
  • An application for an additional indication of the treatment of hemophilia A without factor VIII inhibitors has been filed in April in Japan. (
  • Antidepressant Lexapro is the newest and fastest-growing selective serotonin reuptake inhibitor (SSRI) and is prescribed for more than four million patients in the U.S. The medication was first approved by the U.S. Food and Drug Administration (FDA) in August 2002 for both the initial and maintenance treatment of major depressive disorder. (
  • Some health issues that are considered in conjunction with these foods and nutraceuticals include oxidative stress, obesity, pharyngitis, low cognitive concentration among others. (
  • Oil from moringa seeds is used in foods, perfume, and hair care products, and as a machine lubricant. (
  • 1. By its reference for a preliminary ruling pursuant to Article 234 EC the Bundesverwaltungsgericht (Federal Administrative Court) has referred three questions to the Court of Justice of the European Communities concerning the interpretation of Directive 2001/83/EC of the European Parliament and of the Council of 6 November 2001 on the Community code relating to medicinal products for human use. (
  • Consequently, the Court must here examine the criteria upon which the Member States' authorities have to base their decision to apply the law on medicinal products and the degree of certainty necessary with regard to the pharmacological action of a product for the purpose of classifying it as a medicinal product. (
  • 7. Under Paragraph 69(1) of the German Arzneimittelgesetz (Law on medicinal products, 'the AMG'), the competent authorities are required to take the necessary steps to eliminate infringements that have been confirmed and to prevent future infringements. (
  • They may, in particular, prohibit the placing on the market of medicinal products in, the absence of the necessary authorisation or registration of such products. (
  • In October 2002 the Arzneimittelkommission der deutschen Apotheker (Committee for medicinal products of German pharmacists) informed the Bezirksregierung Lüneburg (District Administration, Lüneburg) that the appellant had announced that from 1 September 2002 it would place on the market a product under the name 'Red Rice 330 mg GPH Kapseln' containing the active substance monacolin k. (
  • A dietary supplement represents a product that contains nutrients derived from food products, and is often concentrated in liquid, capsule, powder or pill form. (
  • Advanced glycation end products in foods and a practical guide to their reduction in the diet. (
  • On the other hand, lipid peroxidation is one of the main reasons for deterioration in food products. (
  • You'll need to avoid foods containing high levels of tyramine ― an amino acid that regulates blood pressure ― such as aged cheeses, sauerkraut, cured meats, draft beer and fermented soy products (for example, soy sauce, miso and tofu). (
  • From 2000 to 2007, U.S. food manufacturers introduced more than 2,700 new soy-based foods, and new soy products continue to appear on your grocer's shelves. (
  • In Europe, the review by the EU Committee for Medicinal Products for Human Use (CHMP) is ongoing. (
  • Antidepressant LEXAPRO was developed by isolating the medicinal component of Celexa (citalopram HBr), molecules known as isomers. (
  • Action of phenolic derivatives (acetaminophen, salicylate, and 5-amino salicylate) as inhibitor of membrane lipid peroxidation and peroxyl radical scavenger. (
  • Particularly, ROCK inhibitor is used for cell culture practice, in part to limit cellular death and limited dedifferentiation, and therefore widely adopted for induced pluripotent stem cells (iPSC) and embryonic stem cell cultures, although studies have shown mixed results for other cells types. (
  • Nutraceuticals is a broad umbrella term that is used to describe any product derived from food sources with extra health benefits in addition to the basic nutritional value found in foods. (
  • This new volume provides important information on potential applications and new developments in functional health foods and nutraceuticals. (
  • It looks at health-promoting properties in functional foods and beverages as well as nutraceuticals. (
  • The IC 50 values of both fractions were found to be significantly lower than the standard acarbose suggesting the presence of potential α-glucosidase inhibitors. (
  • Acarbose as the standard inhibitor exhibited an IC 50 (half maximal inhibitory concentration)value of 10.2 μgml -1 . (
  • By reducing habits that put a higher strain on your cardiovascular system, such as smoking, heavy drinking, eating high fat and high cholesterol foods, and stress, and by increasing habits that are good for your heart, such as good dietary choices and regular exercise, the risk of CVD can be significantly decreased. (
  • Furthermore, ROCK inhibitors may have clinical applications for anti-erectile dysfunction, antihypertension, and tumor metastasis inhibition. (
  • Antioxidant activity of food constituents: An overview. (
  • Specific inhibitors interact with enzymes and block their activity towards their corresponding physiological substrates. (
  • 2. These questions have been raised in proceedings brought by Hecht-Pharma GmbH ('the appellant') contesting a decision of the Bezirksregierung Lüneburg (District Administration, Lüneburg, 'the respondent') prohibiting Hecht-Pharma from marketing a product, which was actually declared as a food supplement and known as 'Red Rice', on the ground that it was a medicinal product that required authorisation but had not been authorised. (
  • 3. The question at the centre of the legal dispute in the main proceedings is whether the product in question comes within the definition of a medicinal product and whether the respondent was entitled to proceed on the basis that it required authorisation. (
  • Any substance or combination of substances which may be administered to human beings with a view to making a medical diagnosis or to restoring, correcting or modifying physiological functions in human beings is likewise considered a medicinal product. (
  • In cases of doubt, where, taking into account all its characteristics, a product may fall within the definition of a "medicinal product" and within the definition of a product covered by other Community legislation, the provisions of this Directive shall apply. (
  • This exotic fruit has amazing medicinal properties which cure a wide number of diseases and ailments. (
  • Fungi also have beneficial medicinal and culinary attributes. (
  • Despite the advantages of taking a multivitamin or getting your vitamin C through various nutritious foods, liposomal vitamin C offers another way to absorb this immune-boosting vitamin, and it may be the most beneficial. (
  • In foods and beverages, a bitterless extract of cascara sagrada is sometimes used as a flavoring agent. (
  • MAOIs can cause dangerous interactions with certain foods and beverages. (