Flutamide. Medical search

An antiandrogen with about the same potency as cyproterone in rodent and canine species.

Compounds which inhibit or antagonize the biosynthesis or actions of androgens.

Compounds that interact with ANDROGEN RECEPTORS in target tissues to bring about the effects similar to those of TESTOSTERONE. Depending on the target tissues, androgenic effects can be on SEX DIFFERENTIATION; male reproductive organs, SPERMATOGENESIS; secondary male SEX CHARACTERISTICS; LIBIDO; development of muscle mass, strength, and power.

The male reproductive organs. They are divided into the external organs (PENIS; SCROTUM;and URETHRA) and the internal organs (TESTIS; EPIDIDYMIS; VAS DEFERENS; SEMINAL VESICLES; EJACULATORY DUCTS; PROSTATE; and BULBOURETHRAL GLANDS).

A potent androgenic steroid and major product secreted by the LEYDIG CELLS of the TESTIS. Its production is stimulated by LUTEINIZING HORMONE from the PITUITARY GLAND. In turn, testosterone exerts feedback control of the pituitary LH and FSH secretion. Depending on the tissues, testosterone can be further converted to DIHYDROTESTOSTERONE or ESTRADIOL.

A potent androgenic metabolite of TESTOSTERONE. It is produced by the action of the enzyme 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE.

Compounds that bind to and inhibit the activation of ANDROGEN RECEPTORS.

Proteins, generally found in the CYTOPLASM, that specifically bind ANDROGENS and mediate their cellular actions. The complex of the androgen and receptor migrates to the CELL NUCLEUS where it induces transcription of specific segments of DNA.

The surgical removal of one or both testicles.

The period following ESTRUS during which the phenomena of estrus subside in those animals in which pregnancy or pseudopregnancy does not occur.

A synthetic hormone used for androgen replacement therapy and as an hormonal antineoplastic agent (ANTINEOPLASTIC AGENTS, HORMONAL).

Antineoplastic agents that are used to treat hormone-sensitive tumors. Hormone-sensitive tumors may be hormone-dependent, hormone-responsive, or both. A hormone-dependent tumor regresses on removal of the hormonal stimulus, by surgery or pharmacological block. Hormone-responsive tumors may regress when pharmacologic amounts of hormones are administered regardless of whether previous signs of hormone sensitivity were observed. The major hormone-responsive cancers include carcinomas of the breast, prostate, and endometrium; lymphomas; and certain leukemias. (From AMA Drug Evaluations Annual 1994, p2079)

A gland in males that surrounds the neck of the URINARY BLADDER and the URETHRA. It secretes a substance that liquefies coagulated semen. It is situated in the pelvic cavity behind the lower part of the PUBIC SYMPHYSIS, above the deep layer of the triangular ligament, and rests upon the RECTUM.

A family of large terrestrial carnivores possessing long legs, coarse guard hairs and a busy tail. It is comprised of hyenas and aardwolves.

A condition caused by the excessive secretion of ANDROGENS from the ADRENAL CORTEX; the OVARIES; or the TESTES. The clinical significance in males is negligible. In women, the common manifestations are HIRSUTISM and VIRILISM as seen in patients with POLYCYSTIC OVARY SYNDROME and ADRENOCORTICAL HYPERFUNCTION.

A selective pre- and post-emergence herbicide. (From Merck Index, 11th ed)

Tumors or cancer of the PROSTATE.

A cytochrome P450 enzyme subtype that has specificity for relatively planar heteroaromatic small molecules, such as CAFFEINE and ACETAMINOPHEN.

A developmental defect in which a TESTIS or both TESTES failed to descend from high in the ABDOMEN to the bottom of the SCROTUM. Testicular descent is essential to normal SPERMATOGENESIS which requires temperature lower than the BODY TEMPERATURE. Cryptorchidism can be subclassified by the location of the maldescended testis.

Renewal or physiological repair of damaged nerve tissue.

A nerve which originates in the lumbar and sacral spinal cord (L4 to S3) and supplies motor and sensory innervation to the lower extremity. The sciatic nerve, which is the main continuation of the sacral plexus, is the largest nerve in the body. It has two major branches, the TIBIAL NERVE and the PERONEAL NERVE.

Diet modification and physical exercise to improve the ability of animals to perform physical activities.

A glycoprotein that is a kallikrein-like serine proteinase and an esterase, produced by epithelial cells of both normal and malignant prostate tissue. It is an important marker for the diagnosis of prostate cancer.

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Services offered to the library user. They include reference and circulation.

A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.

A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)

A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

The freedom of patients to review their own medical, genetic, or other health-related records.

The reproductive organ (GONADS) in female animals. In vertebrates, the ovary contains two functional parts: the OVARIAN FOLLICLE for the production of female germ cells (OOGENESIS); and the endocrine cells (GRANULOSA CELLS; THECA CELLS; and LUTEAL CELLS) for the production of ESTROGENS and PROGESTERONE.

Messages between computer users via COMPUTER COMMUNICATION NETWORKS. This feature duplicates most of the features of paper mail, such as forwarding, multiple copies, and attachments of images and other file types, but with a speed advantage. The term also refers to an individual message sent in this way.

Mechanical food dispensing machines.

The guidelines and policy statements set forth by the editor(s) or editorial board of a publication.

The profession of writing. Also the identity of the writer as the creator of a literary production.

A publication issued at stated, more or less regular, intervals.

The functions and activities carried out by the U.S. Postal Service, foreign postal services, and private postal services such as Federal Express.

A loose confederation of computer communication networks around the world. The networks that make up the Internet are connected through several backbone networks. The Internet grew out of the US Government ARPAnet project and was designed to facilitate information exchange.

Certain tumors that 1, arise in organs that are normally dependent on specific hormones and 2, are stimulated or caused to regress by manipulation of the endocrine environment.

Economic aspects of the nursing profession.

The processes of milk secretion by the maternal MAMMARY GLANDS after PARTURITION. The proliferation of the mammary glandular tissue, milk synthesis, and milk expulsion or let down are regulated by the interactions of several hormones including ESTRADIOL; PROGESTERONE; PROLACTIN; and OXYTOCIN.

A procedure consisting of a sequence of algebraic formulas and/or logical steps to calculate or determine a given task.

The actual costs of providing services related to the delivery of health care, including the costs of procedures, therapies, and medications. It is differentiated from HEALTH EXPENDITURES, which refers to the amount of money paid for the services, and from fees, which refers to the amount charged, regardless of cost.

Pharmacokinetics of flutamide in patients with renal insufficiency. (1/384)

AIMS: The aim of this study was to determine the pharmacokinetic parameters of flutamide, a nonsteroidal antiandrogenic compound, and its pharmacologically active metabolite, hydroxyflutamide, in renal insufficiency. Haemodialysis (HD) clearance of flutamide and hydroxyflutamide was also determined. METHODS: Pharmacokinetic parameters were assessed for flutamide and hydroxyflutamide in 26 male subjects with normal renal function (creatinine clearance by 24 h urine collection, CLcr, greater than 80 ml min(-1) 1.73 m(-2); n=6) or reduced renal function; CLcr=50-80 (n=7), 30-49 (n=3), 5-29 (n=4), and <5 ml min(-1) 1.73 m(-2)-HD (n=6), following a single, oral 250 mg flutamide dose. Subjects undergoing HD received a second 250 mg dose of flutamide 4 h prior to HD; blood and dialysate were collected during HD to determine dialysability of flutamide and hydroxyflutamide. RESULTS: Cmax, tmax, AUC, t1/2, and renal clearance of flutamide and hydroxyflutamide did not differ between groups. Less than 1% of the dose appeared in dialysate as hydroxyflutamide. No serious adverse events were observed. CONCLUSIONS: Renal function did not affect flutamide nor hydroxyflutamide disposition. HD did not alter hydroxyflutamide pharmacokinetics. Dosing adjustments for renal impairment or HD are not indicated for flutamide. (+info)

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. (2/384)

Overexpression of the HER2/Neu protooncogene has been linked to the progression of breast cancer. Here we demonstrate that the growth of prostate cancer LNCaP cells can also be increased by the stable transfection of HER2/Neu. Using AG879, a HER2/Neu inhibitor, and PD98059, a MAP kinase inhibitor, as well as MAP kinase phosphatase-1 (MPK-1), in the transfection assay, we found that HER2/Neu could induce prostate-specific antigen (PSA), a marker for the progression of prostate cancer, through the MAP kinase pathway at a low androgen level. Reporter assays and mammalian two-hybrid assays further suggest this HER2/Neu-induced androgen receptor (AR) transactivation may function through the promotion of interaction between AR and AR coactivators, such as ARA70. Furthermore, we found this HER2/Neu --> MAP kinase --> AR-ARAs --> PSA pathway could not be blocked completely by hydroxyflutamide, an antiandrogen used in the treatment of prostate cancer. Together, these data provide a novel pathway from HER2/Neu to AR transactivation, and they may represent one of the reasons for the PSA re-elevation and hormone resistance during androgen ablation therapy in prostate cancer patients. (+info)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (3/384)

The role of androgen receptor (AR) mutations in androgen-independent prostate cancer (PCa) was determined by examining AR transcripts and genes from a large series of bone marrow metastases. Mutations were found in 5 of 16 patients who received combined androgen blockade with the AR antagonist flutamide, and these mutant ARs were strongly stimulated by flutamide. In contrast, the single mutant AR found among 17 patients treated with androgen ablation monotherapy was not flutamide stimulated. Patients with flutamide-stimulated AR mutations responded to subsequent treatment with bicalutamide, an AR antagonist that blocks the mutant ARs. These findings demonstrate that AR mutations occur in response to strong selective pressure from flutamide treatment. (+info)

Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats. (4/384)

AIM: To develop a new HPLC assay to study the pharmacokinetics of flutamide (Flu) and its active metabolite 2-hydroxyflutamide (HF) in rats. METHODS: Normal or hepatic injury rats were given i.g. Flu 50 mg.kg-1. Reverse phase HPLC was developed with a mu-Bondapak C 18 column. Internal standard was methyltestosterone. The mobile phase was a mixture of methanol:acetonitrile:water:diethyl ether = 40:20:35:1 (vol). Absorbance was measured at lambda 234 nm. RESULTS: The pharmacokinetic parameters of Flu were as follows: in normal rats, K = 0.62 +/- 0.16 h-1, Cl = 6.0 +/- 1.0 L.kg-1.h-1, AUC = 8.6 +/- 1.3 mg.L-1.h, Cmax = 2.4 +/- 0.7 mg.L-1; in hepatic injury rats, K = 0.16 +/- 0.03 h-1, Cl = 0.63 +/- 0.29 L.kg-1.h-1, AUC = 100 +/- 44 mg.L-1.h, Cmax = 6.7 +/- 2.8 mg.L-1. The pharmacokinetic parameters of HF were as follows: in normal rats, K(m) = 0.07 +/- 0.01 h-1, AUC = 219 +/- 22 mg.L-1.h, Cmax = 8.6 +/- 0.6 mg.L-1; in hepatic injury rats, K(m) = 0.05 +/- 0.01 h-1, AUC = 170 +/- 42 mg.L-1.h, Cmax = 3.8 +/- 0.8 mg.L-1. There were significant differences between the parameters of normal and hepatic injury rats (P < 0.01) except AUC of HF (P > 0.05). CONCLUSION: This HPLC assay was sensitive and precise, and the elimination of Flu and HF was inhibited significantly due to hepatic injury. (+info)

Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. (5/384)

Low levels of p27Kip1 in primary prostate cancer specimens have been shown to be associated with higher rates of disease recurrence and poor rates of disease-free survival in patients with localized disease. In this study, we provide the first direct evidence showing that dihydrotestosterone (DHT), a major proliferation regulator of prostate cancer, can down-regulate p27Kip1 and stimulate cyclin-dependent kinase-2 (CDK2) activity in established prostate cancer cell lines. We investigated the cooperative effects of DHT and epidermal growth factor (EGF) on the proliferation of androgen-responsive MDA PCa 2a and MDA PCa 2b prostate cancer cells. DHT and EGF each stimulated proliferation of these cells, but exposure of the cells to DHT and EGF together stimulated greater proliferation. Stimulation of cell proliferation by DHT and/or EGF was associated with increased CDK2 activity and a decreased level of p27Kip1. There seems to be a positive feedback stimulation loop between androgen-induced gene transcription and EGF-stimulated signal transduction, as one could stimulate the synthesis of the receptors for the other. Dual blockade of androgen receptor function with the antiandrogen hydroxyflutamide and EGF receptor superfamily-mediated signal transduction with the anti-EGF receptor monoclonal antibody C225 and the anti-HER2 receptor monoclonal antibody Herceptin significantly enhanced growth inhibition of the MDA PCa 2a cells. Our results demonstrate the importance of counteracting both androgen receptors and EGF receptors in the development of novel therapies for prostate cancer. (+info)

Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay. (6/384)

In this report, p,p'-DDE, a weak androgen receptor (AR) antagonist, has been examined in a Tier I screening battery designed to detect endocrine-active compounds (EACs). The screening battery that was used to examine p,p'-DDE was an abbreviated version of a proposed Tier I screening battery (Cook et al., 1997, Regul. ToxicoL Pharmacol. 26, 60-68) that consisted of a 15-day intact male in vivo battery and an in vitro yeast transactivation system (YTS). In addition, strain sensitivity differences were evaluated using male Crl:CDIGS BR (CD) and Long-Evans (LE) rats. Finally, p,p'-DDE was examined in a Hershberger assay designed to detect AR agonists. In the in vivo male battery using CD rats, responses to p,p'-DDE included organ weight changes (increased relative liver weight and decreased absolute epididymis weight) and hormonal alterations (increased serum estradiol [E2] levels and decreased serum FSH and T4 levels). Responses to p,p'-DDE in LE rats included organ weight changes (increased relative liver weight, absolute epididymis weight, relative accessory sex gland [ASG] unit weight, as well as the individual component weights of the ASG [prostate and seminal vesicles]), and hormonal alterations (increased serum testosterone [T], E2, dihydrotestosterone [DHT], thyroid-stimulating hormone [TSH], and decreased T4 levels). These data demonstrate that there are considerable strain-sensitivity differences to p,p'-DDE exposure. The described in vivo male battery using CD rats did not identify p,p'-DDE as an EAC. In contrast, the in vivo male battery using LE rats identified p,p'-DDE as a EAC. Evaluation of the data for the LE rats demonstrate that p,p'-DDE appears to be acting as an AR antagonist whose primary effects are more potent centrally than peripherally. In the YTS for the AR, p,p'-DDE had an EC50 value of 3.5 x 10(-4) M; however, in the AR YTS competition assay, p,p'-DDE did not inhibit DHT binding to the AR. p,p'-DDE was inactive in the YTS containing the estrogen receptor or progesterone receptor at the concentrations evaluated. In the Hershberger assay, p,p'-DDE administration caused antiandrogen-like effects characterized by attenuation of the testosterone propionate-induced increases in reproductive-organ weights. In summary, these data suggest that strain selection will affect the ability to detect certain weak EACs. However, a Tier I screening battery consisting of both in vivo and in vitro endpoints would reduce the chance that weak-acting compounds such as p,p'-DDE would not be identified as potential EACs. (+info)

Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. (7/384)

Testosterone acts on cells through intracellular transcription-regulating androgen receptors (ARs). Here, we show that mouse IC-21 macrophages lack the classical AR yet exhibit specific nongenomic responses to testosterone. These manifest themselves as testosterone-induced rapid increase in intracellular free [Ca(2+)], which is due to release of Ca(2+) from intracellular Ca(2+) stores. This Ca(2+) mobilization is also inducible by plasma membrane-impermeable testosterone-BSA. It is not affected by the AR blockers cyproterone and flutamide, whereas it is completely inhibited by the phospholipase C inhibitor U-73122 and pertussis toxin. Binding sites for testosterone are detectable on the surface of intact IC-21 cells, which become selectively internalized independent on caveolae and clathrin-coated vesicles upon agonist stimulation. Internalization is dependent on temperature, ATP, cytoskeletal elements, phospholipase C, and G-proteins. Collectively, our data provide evidence for the existence of G-protein-coupled, agonist-sequestrable receptors for testosterone in plasma membranes, which initiate a transcription-independent signaling pathway of testosterone. (+info)

Combined treatment with the 5 alpha-reductase inhibitor PNU 157706 and the antiandrogen flutamide on the Dunning R3327 prostatic carcinoma in rats. (8/384)

The steroid 5 alpha-reductase enzyme catalyzes the conversion of testosterone to the potent androgen 5 alpha-dihydrotestosterone (DHT). PNU 157706, a novel, potent and selective dual 5 alpha-reductase inhibitor, was reported to be effective in inhibiting the growth of established tumors in the Dunning R3327 rat prostatic carcinoma model. We have studied the efficacy of combined treatment with PNU 157706 and the antiandrogen flutamide in this prostatic tumor in rats. Rats with tumor diameters of about 1 cm were treated orally 6 days a week for 9 weeks with PNU 157706 (10 mg/kg per day) alone or in combination with flutamide (1 and 5 mg/kg per day). Animals were killed 24 h after the last treatment and ventral prostates were removed for testosterone and DHT determination. PNU 157706 reduced the growth of established tumors by 36%; flutamide showed a slight effect at 1 mg/kg per day (24% inhibition), while at the dose of 5 mg/kg per day it reduced tumor growth by 48%. The combination of PNU 157706 with the lower dose of flutamide caused an additive tumor growth inhibition (60%) and the combination with the higher dose of flutamide resulted in a better inhibition of tumor growth (68%) than did either treatment alone. Castration resulted in marked tumor growth inhibition (76%). Ventral prostate weight was more markedly reduced by PNU 157706 treatment than by flutamide; combined treatment was as effective as castration. Prostatic DHT content was markedly reduced by PNU 157706 (93%), whereas prostatic testosterone increased (137%). Concomitant treatment with flutamide partially antagonized the testosterone increase induced by PNU 157706 and did not modify the already considerable suppression of DHT. These data show that the inhibitory effects of PNU 157706 and flutamide on Dunning prostatic tumor growth are additive, thus supporting the rationale of this combination therapy in advanced prostate cancer, in order to achieve adequate androgen blockade with minimal side-effects. (+info)

A favourable feature of flutamide therapy has been its lesser effect on libido and sexual potency; fewer than 20% of patients ... Brogden RN, Clissold SP (August 1989). "Flutamide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, ... of those given flutamide alone (Johansson et al. 1987; Lund & Rasmussen 1988). Gunther Göretzlehner; Christian Lauritzen; ... treated with flutamide alone reported such changes. In contrast, nearly all patients treated with oestrogens or estramustine ...

https://en.wikipedia.org/wiki/Estrogen_(medication)

A favourable feature of flutamide therapy has been its lesser effect on libido and sexual potency; fewer than 20% of patients ... Androgen receptor antagonists such as flutamide and bicalutamide cause little to no decrease in sexual desire in women. Low ... Among the slight and temporary adverse events [of flutamide], most frequently reported and not requesting treatment ... Brogden RN, Clissold SP (August 1989). "Flutamide. A preliminary review of its pharmacodynamic and pharmacokinetic properties, ...

https://en.wikipedia.org/wiki/Sexual_motivation_and_hormones

Due to the relatively short half-lives of flutamide and hydroxyflutamide, flutamide must be taken three times daily at 8-hour ... with respective incidences far below those of flutamide and nilutamide. In contrast to flutamide and nilutamide, no unique or ... Flutamide and nilutamide are first-generation NSAAs, similarly to bicalutamide, and all three drugs possess the same core ... In a large-scale clinical trial that compared 750 mg/day flutamide and 250 mg/day CPA monotherapies in the treatment of men ...

https://en.wikipedia.org/wiki/Comparison_of_bicalutamide_with_other_antiandrogens

Flutamide is safe and effective. Bicalutamide: A pure antiandrogen. It is effective similarly to flutamide but is much safer as ... Flutamide: A pure antiandrogen. It has been found to possess equivalent or greater effectiveness than spironolactone, ... Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (2017). "Flutamide-induced hepatotoxicity: ethical ... April 2008). "Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in ...

https://en.wikipedia.org/wiki/Hirsutism

Flutamide. Nonsteroidal. AR antagonist. Eulexin. Oral. 1983. Available. 712,000 Gestonorone caproate. Steroidal. Progestin. ... Flutamide. ,0.0057 AR antagonists act by directly binding to and competitively displacing androgens like testosterone and DHT ... The nonsteroidal antiandrogen flutamide was first reported in 1967.[21] It was introduced in 1983 and was the first ... In patients receiving flutamide at the usual dosage of 250 mg every 8 hours, the minimal plasma concentration of ...

https://en.wikipedia.org/wiki/Antiandrogen

FLUTAMIDE 210. FLUTICASONE PROPIONATE 211. FLUVOXAMINE MALEATE 212. FORMESTANE 213. FOSFESTRIL SODIUM ...

https://en.wikipedia.org/wiki/Schedule_H

In addition, flutamide, nilutamide, and enzalutamide have been found to cause convulsions and/or death in mice at sufficiently ... administration of flutamide in a group of normally-cycling women produced a clinical improvement of acne and hirsutism without ... Luo S, Martel C, Chen C, Labrie C, Candas B, Singh SM, Labrie F (December 1997). "Daily dosing with flutamide or Casodex exerts ... The IC50 values are 44 μM for flutamide (as hydroxyflutamide), 21 μM for nilutamide, 5.2 μM for bicalutamide, and 3.6 μM for ...

https://en.wikipedia.org/wiki/Pharmacology_of_bicalutamide

Several trials demonstrated complete clearing of acne with flutamide [62,77]. Flutamide used in combination with an [oral ... Bicalutamide and flutamide, though not nilutamide, can also be classified as toluidides. All three of the compounds share a ... administration of flutamide in a group of normally-cycling women produced a clinical improvement of acne and hirsutism without ... Luo S, Martel C, Chen C, Labrie C, Candas B, Singh SM, Labrie F (December 1997). "Daily dosing with flutamide or Casodex exerts ...

https://en.wikipedia.org/wiki/Bicalutamide

"The first clinical experience on efficacy of topical flutamide on melasma compared with topical hydroquinone: a randomized ...

https://en.wikipedia.org/wiki/Melasma

Dukes M, Furr BJ, Hughes LR, Tucker H, Woodburn JR (2000). "Nonsteroidal progestins and antiprogestins related to flutamide". ...

https://en.wikipedia.org/wiki/ZM-182345

... with flutamide] [10, 11]. "Low-dose flutamide (125 mg/day) as maintenance therapy in the treatment of hirsutism"] Check ,url= ... However, it has been reported on the basis of very limited evidence that this may not be the case with flutamide. There is no ... Liver toxicity is much more rare with bicalutamide than with flutamide (which has an estimated incidence rate of 0.03% or 3 per ... Minimal rates of reduced sex drive have also been associated with the related NSAA flutamide. These findings are in accordance ...

https://en.wikipedia.org/wiki/Side_effects_of_bicalutamide

Goldspiel, Barry R.; Kohler, David R. (June 1990). "Flutamide: An Antiandrogen for Advanced Prostate Cancer". DICP. 24 (6): 616 ... flutamide, and spironolactone. Medications that are probably associated with gynecomastia include calcium channel blockers such ...

https://en.wikipedia.org/wiki/Gynecomastia

Several trials demonstrated complete clearing of acne with flutamide [62,77]. Flutamide used in combination with an [oral ... Flutamide has generally been found to reduce symptoms of acne by 80 or 90% even at low doses, with several studies showing ... Flutamide is also no longer recommended due to excessive risk of hepatotoxicity and liver failure in men with prostate cancer. ... Flutamide has also been employed as an antiandrogen in transgender women, with at least two treatment centers reporting its ...

https://en.wikipedia.org/wiki/Medical_uses_of_bicalutamide

As such, the use of flutamide for acne has become increasingly limited, and it has been argued that continued use of flutamide ... Although effective, flutamide has a risk of serious liver toxicity, and cases of death in women taking even low doses of the ... Flutamide, a pure antagonist of the androgen receptor, is effective in treating acne in women. It appears to reduce acne ... In one study, flutamide decreased acne scores by 80% within three months, whereas spironolactone decreased symptoms by only 40 ...

https://en.wikipedia.org/wiki/Acne

Due to its risks, the use of flutamide in cisgender and transgender women is now limited and discouraged. Flutamide and ... Flutamide and nilutamide have relatively high toxicity, including considerable risks of liver damage and lung disease. ... Bicalutamide is said to have excellent tolerability and safety relative to flutamide and nilutamide, as well as in comparison ... ISBN 978-0-7817-6879-5. Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (March 2017). "Flutamide- ...

https://en.wikipedia.org/wiki/Feminizing_hormone_therapy

It was first introduced for medical use in 1987 in France and was the second NSAA to be marketed, with flutamide preceding it ... For comparison, the risk of elevated liver enzymes has been reported as 4 to 62% in the case of flutamide. The risk of ... Similarly to flutamide, nilutamide exhibits mitochondrial toxicity in hepatocytes by inhibiting respiratory complex I (NADH ... Between 1986 and 2003, the numbers of published cases of hepatotoxicity for antiandrogens totaled 46 for flutamide, 21 for ...

https://en.wikipedia.org/wiki/Nilutamide

Flutamide became the first NSAA to be tested clinically. Later the NSAAs bicalutamide and nilutamide were developed. The ... Flutamide is an arylpropionamide analog with pure antiandrogenic properties, seen in figure 4. It is completely absorbed from ... Bicalutamide is not as hepatotoxic as flutamide and nilutamide and has a longer half-life, of 6 days in humans, that allows ... Bicalutamide has a cyano group at the para position instead of a nitro group like flutamide and nilutamide. This change in ...

https://en.wikipedia.org/wiki/Discovery_and_development_of_antiandrogens

... and the major active metabolite of flutamide, which is considered to be a prodrug of hydroxyflutamide as the active form. It ... "Relative potencies of Flutamide and Casodex: preclinical studies". Endocrine Related Cancer. 3 (3): 229-241. doi:10.1677/erc. ...

https://en.wikipedia.org/wiki/Hydroxyflutamide

There is tentative evidence for flutamide in women; however, it is associated with relatively high rates of liver problems. ... Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side ... Yazdabadi, A.; Sinclair, R. (2011). "Treatment of female pattern hair loss with the androgen receptor antagonist flutamide". ... Other medications include ketoconazole, and in female androgenic alopecia spironolactone and flutamide. Combinations of ...

https://en.wikipedia.org/wiki/Management_of_hair_loss

Nonsteroidal antiandrogens like flutamide and bicalutamide are more efficacious as antiandrogens than CPA in castrated animals ... In addition, CPA alone increased prostate weight by 60%, whereas flutamide had no effect. As a result of its weak intrinsic ... Accordingly, CPA shows weak androgenic effects in the liver in rodents which can be blocked by flutamide. A paradoxical effect ... The effects of flutamide and the steroidal derivatives, cyproterone acetate, chlormadinone acetate, megestrol acetate and ...

https://en.wikipedia.org/wiki/Pharmacology_of_cyproterone_acetate

... antiandrogens such as nonsteroidal antiandrogens like flutamide, nilutamide, and bicalutamide; and androgen synthesis ...

https://en.wikipedia.org/wiki/Gonadotropin-releasing_hormone_agonist

... of women reported satisfaction with the control of their acne with flutamide.[125] Although effective, flutamide has a risk of ... Flutamide, a pure antagonist of the androgen receptor, is effective in treating acne in women.[112][120] It appears to reduce ... Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (March 2017). "Flutamide-induced hepatotoxicity: ... the use of flutamide for acne has become increasingly limited,[125][127][128] and it has been argued that continued use of ...

https://en.wikipedia.org/wiki/Acne_vulgaris

However, the use of flutamide for acne is limited by its liver toxicity. Bicalutamide is a potential alternative to flutamide ... In one study, flutamide decreased acne scores by 80% within 3 months, whereas spironolactone decreased symptoms by only 40% in ... In addition, some clinical research has found that flutamide is more effective than spironolactone in the treatment of acne. ... Spironolactone, the 5α-reductase inhibitor finasteride, and the nonsteroidal antiandrogen flutamide all appear to have similar ...

https://en.wikipedia.org/wiki/Spironolactone

To further test the role of activated androgen receptors on AHN, flutamide, an antiandrogen drug that competes with ... Zhang JM, Tonelli L, Regenold WT, McCarthy MM (2010). "Effects of neonatal flutamide treatment on hippocampal neurogenesis and ... In preadolescent male rats, neonatal rats treated with flutamide developed more depression-like symptoms compared to control ... Dihydrotestosterone increased the number of BrdU cells, while flutamide inhibited these cells. Moreover, estrogens had no ...

https://en.wikipedia.org/wiki/Androgen

Flutamide. Nonsteroidal. ,0.01. ,0.2. ,0.1. ,0.1 Homovanillic acid. Nonsteroidal. ,0.01. ,0.2. ,0.1. ,0.1 ...

https://en.m.wikipedia.org/wiki/Sex_hormone-binding_globulin

Bicalutamide: A pure antiandrogen.[23][24][25] It is effective similarly to flutamide but is much safer as well as better- ... Flutamide: A pure antiandrogen.[16] It has been found to possess equivalent or greater effectiveness than spironolactone, ... Giorgetti R, di Muzio M, Giorgetti A, Girolami D, Borgia L, Tagliabracci A (2017). "Flutamide-induced hepatotoxicity: ethical ... April 2008). "Comparison of the clinical efficacy of flutamide and spironolactone plus ethinyloestradiol/cyproterone acetate in ...

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Poyet P, Labrie F (October 1985). "Comparison of the antiandrogenic/androgenic activities of flutamide, cyproterone acetate and ...

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A list of US medications equivalent to Flutamide is available on the Drugs.com website. ... Flutamide is a medicine available in a number of countries worldwide. ... Flutamide. In the US, Flutamide (flutamide systemic) is a member of the following drug classes: antiandrogens, hormones/ ...

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A study by researchers from Emory University and Indiana University found that the beneficial effects daily exercise can have on the regeneration of nerves also require androgens such as testosterone in both males and females. It is the first report of both androgen-dependence of exercise on nerve regeneration and of an androgenic effect of exercise in females.. ...

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Professional guide for Flutamide. Includes: pharmacology, pharmacokinetics, contraindications, interactions, adverse reactions ... Serum transaminase levels should be measured prior to starting treatment with flutamide. Flutamide is not recommended in ... Flutamide is not indicated for use in women.. Patient Education. • Discuss specific use of drug and side effects with patient ... Hypersensitivity to flutamide or any component of the formulation; severe hepatic impairment (evaluate baseline hepatic enzymes ...

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Flutamide; CAS Number: 13311-84-7; EC Number: 236-341-9; Synonyms: 2-Methyl-N-4-nitro-3-(trifluoromethyl)phenylpropanamide; ... Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of ... Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro. It ... has also been used to study the effects of flutamide on anogenital distance and nipple retention. ...

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Flutamide belongs to a class of drugs known as anti-androgens (anti-testosterone). Testosterone, a natural hormone, helps ... Flutamide works by blocking the effects of testosterone, thereby slowing the growth and spread of... ...

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Flutamide works by blocking testosterone receptors on the prostate cells, and therefore preventing testosterone from attaching ... How to Take Flutamide. Flutamide is given as a capsule, taken three times a day (spaced every 8 hours). For patients who cannot ... Possible Side Effects of Flutamide. There are a number of things you can do to manage the side effects of flutamide. Talk to ... Flutamide is available through retail or mail order pharmacy. Your oncology team will work with your prescription drug plan to ...

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Flutamide is used to treat prostate cancer in various stages. This drug is given in conjunction with other drugs such as ... Flutamide is used in the treatment of prostate cancers, which are dependent on testosterone for growth control. By blocking the ... Flutamide (Eulexin®) is an anti-androgenic molecule that blocks the effects of androgens (sex hormones), such as testosterone, ... Side effects may differ from those listed above if flutamide is being taken with other medications. Though very rare, there is ...

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The addition of flutamide to bilateral orchiectomy does not result in a clinically meaningful improvement in survival among ... for flutamide as compared with placebo was 0.91 (90 percent confidence interval, 0.81 to 1.01). Flutamide was not associated ... Bilateral orchiectomy with or without flutamide for metastatic prostate cancer N Engl J Med. 1998 Oct 8;339(15):1036-42. doi: ... Results: Of the 1387 patients who were enrolled in the trial, 700 were randomly assigned to the flutamide group and 687 to the ...

https://pubmed.ncbi.nlm.nih.gov/9761805/?dopt=Abstract

Flutamide, 125 mg, capsule, brown, imprinted with par 753 slide 2 of 5 Flutamideslide 3 of 5, Flutamide, 125 mg, capsule, beige ... Flutamide is given in combination with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or ... Flutamide may also be used for purposes not listed in this medication guide. ... Flutamide, 125 mg, capsule, brown/white, imprinted with 2227, WPI slide 1 of 5 Flutamideslide 2 of 5, ...

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It works in the body to prevent the actions of androgens (male hormones). Flutamide is used together with another hormone to ... Flutamide may also be used for purposes not listed in this medication guide. ... Flutamide should never be taken by a woman or a child.. Although flutamide is not for use by women, this medicine can cause ... What is flutamide?. Flutamide is an antiandrogen. It works in the body to prevent the actions of androgens (male hormones). ...

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Flutamide belongs to a group of medications known as nonsteroidal antiandrogens. Nonsteroidal antiandrogens such as flutamide ... Flutamide belongs to a group of medications known as nonsteroidal antiandrogens. Nonsteroidal antiandrogens such as flutamide ... Anemia: Flutamide may cause low levels of red blood cells. If you experience symptoms of reduced red blood cell count (anemia) ... Liver function: Flutamide is broken down and removed from the body by the liver and may cause liver problems. People with liver ...

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Participants will take flutamide. Drug: Flutamide Participants will take one 125-mg flutamide capsule twice a day for two ... Effectiveness of Flutamide in Treating Women With Premenstrual Dysphoric Disorder. The safety and scientific validity of this ... Flutamide, a medication that blocks the action of testosterone and other mood-influencing hormones, may be helpful in ... Participants will take placebo flutamide. Drug: Placebo Participants will take a lactose capsule twice a day for two menstrual ...

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Examining the potency and safety of flutamide in treating hereditary hair loss and its suitability as a topical treatment for ... Examining Flutamides Hair Growth Promoting Properties. Flutamide is a non-steroid antiandrogen binding to androgen receptors ... Oral flutamide is used in women to treat hirsutism (excess body hair) and acne and in men to treat prostate cancer. One ... Antiandrogenic effects of flutamide have lead to its use as a hair loss treatment in women and it is sometimes speculated that ...

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Thorough work-ups excluded other possible causes than flutamide.. Conclusions:. Flutamide appears to cause hepatotoxic effects ... Fatal and Nonfatal Hepatotoxicity Associated with Flutamide Diane K. Wysowski, PhD; Joel P. Freiman, MD, MPH; John B. Tourtelot ... From the time of marketing of flutamide in February 1989 through March 1991, the Food and Drug Administration received reports ... Nineteen patients treated with flutamide for prostate cancer or benign prostatic hypertrophy (for Investigation of a New Drug ...

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Effect of flutamide on.... *Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, ... Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo ... Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo ... Effect of flutamide on survival in patients with pancreatic cancer: results of a prospective, randomised, double blind, placebo ...

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A potential flutamide-withdrawal prostate cancer cell model The growth of ARCaP cells stimulated by flutamide and repressed by ... Effect of flutamide and flutamide plus castration on prostate size in patients with previously untreated prostate cancer. ... Examination of the change in plasma concentration of OH-flutamide in low-dose flutamide (250 mg/day) monotherapy for prostate ... Flutamide therapy for carcinoma of the prostate. Flutamide therapy for carcinoma of the prostate. Airhart, R.A.; Barnett, T.F ...

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... with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. ... As first-line therapy, patients were administered enzalutamide (n = 29) or flutamide (n = 26). In the flutamide group, 18 ... Castration-resistant prostate cancer Enzalutamide Flutamide This is a preview of subscription content, log in to check access. ... Nishimura K, Arichi N, Tokugawa S et al (2007) Effects of flutamide as a second-line agent for maximum androgen blockade of ...

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B, effects of flutamide. P and ADf, tumors treated with placebo or flutamide, respectively, for 4 d. The blots were developed ... Flutamide Insensitivity in Androgen-Independent Cancer. The inability of the antiandrogens flutamide and Casodex to inhibit ... Flutamide is more potent than Casodex in mice (18, 19). We chose this drug to address whether a specialized molecular imaging ... Imaging androgen receptor function during flutamide treatment in the LAPC9 xenograft model. Romyla Ilagan, Liquin Joann Zhang, ...

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Flutamide (By mouth). Flutamide (FLOO-ta-mide). Treats prostate cancer.. Brand Name(s): There may be other brand names for this ... Flutamide is taken with other medicines to treat prostate cancer. Take all other medicines your doctor has prescribed as part ... You should not use this medicine if you have had had an allergic reaction to flutamide, or if you have severe liver disease. ...

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He was immediately put on the Lupron shot every 4 month and Flutamide administered by pill daily. The PSA went down to 1.6 and ... They immediately stopped the Flutamide and put him on one pill of casodex daily in conjunction with the Lupron shot every 4 ...

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In the current work, a sustained drug delivery system of flutamide (FLT) was developed using chitosan (CS) and dextran sulphate ... Jayakumar Rangasamy, and Lakshmanan, V. - K., "Enhanced delivery system of flutamide loaded chitosan-dextran sulphate ... Enhanced delivery system of flutamide loaded chitosan-dextran sulphate nanoparticles for prostate cancer ... Flutamide, Fourier Transform Infrared, Humans, in vitro study, lactate dehydrogenase, Light, male, Materials Testing, Mice, ...

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Effect of the multidrug resistance protein on the transport of the antiandrogen flutamide. Grzywacz, M.J., Yang, J.M., Hait, W. ... Steady-state hydroxyflutamide plasma levels after the administration of two dosage forms of flutamide. Asade, R.H., Prizont, L ... There were significant differences between the wild-type and MRP1-overexpressing cells in efflux and accumulation of flutamide ... the active metabolite of flutamide) levels by high-performance liquid chromatography [34]. ...

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Prostate cancer dosing for flutamide, frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy ... encoded search term (flutamide ((flutamide))) and flutamide ((flutamide)) What to Read Next on Medscape ... Hospitalization and rarely death have been reported due to hepatic failure associated with flutamide use. Hepatic failure may ...

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Flutamide (Eulexin®) is an anti-androgenic molecule that blocks the effects of androgens (sex hormones), such as testosterone , in the body by preventing its entry into cells or its binding to necessary receptors in the cell nuclei. (cancerquest.org)
Eulexin (Flutamide) is a popular drug for treating prostate cancer. (dutypharmacy.com)
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Flutamide (eulexin) antiandrogen hormone therapy side effects, how it's given, how it works, precautions and self care tips in treatment of advanced prostate cancer. (ypejexilu.ru)
Flutamide, sold under the brand name eulexin among others, is a nonsteroidal antiandrogen (nsaa) which is used primarily to treat prostate cancer. (ypejexilu.ru)
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300 mg/day and flutamide (Eulexin 250 mg, three times a day). (businessgeo.ga)
In general, flutamide the active ingredient contained in Eulexin has been used concomitantly with LHRH agonists or after bilateral orchiectomy. (edyl.info)
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Eulexin is often generically prescribed as flutamide. (pharmacyvictoria.com)

It has also been used to study the effects of flutamide on anogenital distance and nipple retention. (sigmaaldrich.com)
There are a number of things you can do to manage the side effects of flutamide. (oncolink.org)
Antiandrogenic effects of flutamide have lead to its use as a hair loss treatment in women and it is sometimes speculated that its topical applications might also be suitable for men. (greyhairloss.com)
Nishimura K, Arichi N, Tokugawa S et al (2007) Effects of flutamide as a second-line agent for maximum androgen blockade of hormone refractory prostate cancer. (springer.com)
Common side effects of flutamide include diarrhea, hot flashes, decreased sexual desire, and the inability to get or maintain an erection. (rxwiki.com)
Learn about the potential side effects of flutamide. (ypejexilu.ru)
Therefore, little data are available on the side effects of flutamide alone. (edyl.info)
One study evaluated the effects of flutamide and an as neoadjuvant therapy to in B 2-C prostatic carcinoma and the other study evaluated flutamide and an LHRH as the sole therapy in stage D 2 metastatic carcinoma. (edyl.info)
No information is available on the relationship of age to the effects of flutamide in the pediatric population. (inam.info)

Flutamide may also be used for purposes not listed in this medication guide. (uofmhealth.org)
Flutamide, a medication that blocks the action of testosterone and other mood-influencing hormones, may be helpful in alleviating symptoms of PMDD. (clinicaltrials.gov)
Therefore, given the current level of clinical data, it seems fair to say that the margin of success as a hair loss treatment is too small for flutamide to be regarded as an effective medication for hair loss, while the health risks involved are too high. (greyhairloss.com)
Flutamide is a prescription medication used together with another medication (called an LHRH-agonist) to treat certain types of prostate cancer. (rxwiki.com)

Take flutamide at around the same times every day. (medlineplus.gov)
Take flutamide exactly as directed. (medlineplus.gov)
Continue to take flutamide along with the LHRH agonist treatment even if you feel well. (medlineplus.gov)
Women who are or may become pregnant should not take flutamide. (medlineplus.gov)
If you take flutamide while you are pregnant, call your doctor. (medlineplus.gov)
The side effects profile of Marijuana, Medical may be altered if you take Flutamide. (cvs.com)
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During the treatment phase, participants will be randomly assigned to take flutamide or placebo for 2 months. (clinicaltrials.gov)
You may not be able to take flutamide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. (speranta.tv)
Do not take flutamide without first talking to your doctor if you are breast-feeding. (speranta.tv)
I take flutamide to lower testosterone levels in my system that in connection with my sickle cell trait causes chronic priapism. (druginformer.com)

In this study, we address the mechanism of a nonsteroidal antiandrogen called flutamide by molecular imaging of androgen receptor function and compare the results with the effects of androgen deprivation by castration. (aacrjournals.org)
Flutamide (FLU), an oral, nonsteroidal antiandrogen drug used in the treatment of prostate cancer, is associated with idiosyncratic hepatotoxicity that sometimes causes severe liver damage, including cholestasis, jaundice, and liver necrosis. (ovid.com)
Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicle. (ypejexilu.ru)
When flutamide is dissolved in hydrochloric acid, color formation occurs flutamide did, however, give rise to more side effects than were experienced in the castration arm.Flutamide is a nonsteroidal antiandrogen that acts by binding to and blocking intracellular androgen receptors in target tissues including testes, prostate, skin, and hair follicle.Flutamide indications, dosage, side effects and precautions. (ypejexilu.ru)
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Flutamide is indicated for the treatment of advanced prostatic carcinoma in which suppression of testosterone.Flutamide is used together with a luteinizing hormonereleasing hormone (lhrh) agonist to treat metastatic flutamide belongs to the group of medicines called antiandrogens.Warnings and precautions side effects and adverse reactions drug interactions, overdosage flutamide + goserelin acetate implant + radiation versus radiation alone.Flutamide get uptodate information on flutamide side effects, uses, dosage flutamide treats prostate cancer. (ypejexilu.ru)
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Flutamide comes as a capsule to take by mouth. (medlineplus.gov)
Flutamide is given as a capsule, taken three times a day (spaced every 8 hours). (oncolink.org)
Flutamide is taken in capsule form usually several times a day. (cancerquest.org)
Participants will take one 125-mg flutamide capsule twice a day for two menstrual cycles. (clinicaltrials.gov)

To achieve treatment benefit in Stage D 2 metastatic prostate cancer, initiate flutamide with the LHRH agonist and continue until disease progression. (drugs.com)
The addition of flutamide to bilateral orchiectomy does not result in a clinically meaningful improvement in survival among patients with metastatic prostate cancer. (nih.gov)
Alternative anti-androgen therapy (AAT) with flutamide after combined androgen blockade (CAB) therapy with bicalutamide for metastatic prostate cancer is common. (springer.com)

To identify and describe patients with hepatotoxicity possibly caused by flutamide, an antiandrogen drug. (annals.org)
Flutamide, an antiandrogen drug, is widely used for the treatment of prostate cancer. (aspetjournals.org)

flutamide ( floo -tă-myd) n. an anti-androgen commonly used in the treatment of prostate cancer, either alone or in combination with gonadorelin analogues. (encyclopedia.com)
FLUTAMIDE (FLOO ta mide) blocks the effect of the male hormone called testosterone. (cvs.com)

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Flutamide is in a class of medications called nonsteroidal antiandrogens. (medlineplus.gov)
Flutamide belongs to a group of medications known as nonsteroidal antiandrogens . (medbroadcast.com)
Nonsteroidal antiandrogens such as flutamide block the effect of the male hormone testosterone in the body. (medbroadcast.com)
In another study of a human scalp graft that was transplanted onto mice, it was shown that topically applied antiandrogens, such as flutamide and finasteride, are effective in extending hair length and diameter as well as in increasing the number of hairs per graft. (greyhairloss.com)
Flutamide belongs to a group of drugs called nonsteroidal antiandrogens. (rxwiki.com)
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Oral flutamide is used in women to treat hirsutism (excess body hair) and acne and in men to treat prostate cancer. (greyhairloss.com)
Arm I: Patients receive oral flutamide once daily. (knowcancer.com)
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Flutamide is given in combination with another medicine called a luteinizing (LOO-tee-in-ize-ing) hormone-releasing hormone, or LHRH. (uofmhealth.org)

Not all side effects for flutamide may be reported. (inam.info)

Flutamide tablets are contraindicated in people suffering from hepatic impairment. (dutypharmacy.com)
Álvarez Lueje A et al (1998) Electrochemical study of flutamide, an anticancer drug, and its polarographic, UV spectrophotometric and HPLC determination in tablets. (springer.com)
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We randomly assigned patients who had never received antiandrogen therapy and who had distant metastases from adenocarcinoma of the prostate to treatment with bilateral orchiectomy and either flutamide or placebo. (nih.gov)
Of the 1387 patients who were enrolled in the trial, 700 were randomly assigned to the flutamide group and 687 to the placebo group. (nih.gov)
Flutamide was not associated with enhanced benefit in patients with minimal disease. (nih.gov)
Nineteen patients treated with flutamide for prostate cancer or benign prostatic hypertrophy (for Investigation of a New Drug or off-label use). (annals.org)
From the time of marketing of flutamide in February 1989 through March 1991, the Food and Drug Administration received reports of 19 patients in the United States who developed serious hepatotoxicity while using flutamide. (annals.org)
Fourteen patients had resolution of abnormal liver function test results after discontinuing or decreasing the dose of flutamide, but five patients died of progressive liver disease. (annals.org)
Flutamide appears to cause hepatotoxic effects in certain patients. (annals.org)
In our three-year experience with the use of flutamide for the treatment of carcinoma of the prostate, 20 patients with previously untreated stage D carcinoma of the prostate were enrolled in a 12-week double-blind study. (eurekamag.com)
Seven patients received 1.5 gm of flutamide daily, seven patients received 0.75 gm of flutamide daily, and six patients received 1.0 mg of diethylstilbestrol daily. (eurekamag.com)
Two patients receiving flutamide did not complete the 12-week study. (eurekamag.com)
Six patients receiving flutamide and three patients receiving diethylstilbestrol had objective evidence of improvement. (eurekamag.com)
Of the patients receiving flutamide, 50% were alive at one year, and 43% were alive at two years. (eurekamag.com)
Three of the original 14 patients started on flutamide are alive at 36, 33, and 24 months. (eurekamag.com)
In addition, we continued clinical evaluation of flutamide as an open study, enrolling six other patients (four with stage D and two with stage C carcinoma of the prostate). (eurekamag.com)
At present, four are still being followed up at 13, 15, 20 and 24 months, demonstrating that flutamide can give positive results to some patients whose condition is deteriorating despite diethylstilbestrol therapy. (eurekamag.com)
In our hospital, 55 patients were diagnosed with CRPC after CAB therapy and administered flutamide or enzalutamide between May 2014 and December 2017. (springer.com)
Patients with flutamide failure were administered enzalutamide. (springer.com)
As first-line therapy, patients were administered enzalutamide ( n = 29) or flutamide ( n = 26). (springer.com)
In the flutamide group, 18 patients showed disease progression and were administered enzalutamide. (springer.com)
AAT with subsequent flutamide after CAB therapy with bicalutamide may be suitable for some CRPC patients. (springer.com)
OBJECTIVES: I. Determine the ability of flutamide to reduce the incidence of prostate cancer in patients with high grade prostatic intraepithelial neoplasia. (knowcancer.com)
Periodic liver function tests and sperm count determinations must be performed in patients on long-term treatment with flutamide. (rxwiki.com)
Accordingly, flutamide should be used with caution in those patients with cardiac disease. (rxwiki.com)
Flutamide is a nonsteroid antiandrogen that has been found effective in hirsute patients, although its mechanism of action is unclear. (soulcysters.com)
The most important result of the present study was that flutamide restored ovulation in anovulatory PCOS patients. (soulcysters.com)
Flutamide is a nonsteroid antiandrogen of known efficacy in hirsute patients, but it is not clear whether it acts only by blocking androgen receptors or also by inhibiting the biosynthesis of androgens. (soulcysters.com)
To evaluate whether, by blocking androgen action, flutamide can decrease and normalize vascular resistance in the uterine artery in patients with polycystic ovary syndrome (PCOS). (curehunter.com)
The low uterine perfusion that characterizes patients with PCOS can be improved by the antiandrogenic effect of flutamide . (curehunter.com)
Efficacy of abiraterone combined with flutamide on patients with prostate cancer (PCa) and its effect on levels of miR-493-5p and miR-195-5p contained in serum were investigated. (spandidos-publications.com)
Eighty-four patients were treated with abiraterone combined with flutamide as a study group, 62 patients were treated with abiraterone alone as a control group. (spandidos-publications.com)
In conclusion, abiraterone combined with flutamide has better curative effect and lower incidence of adverse reactions in patients with metastatic castration-resistant PCa (CRPC) than abiraterone alone, and can increase the expression levels of miR-493-5p and miR-195-5p in patient serum. (spandidos-publications.com)
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Flutamide capsules are contraindicated in patients with severe hepatic impairment baseline hepatic enzymes should be evaluated prior to treatment. (edyl.info)
Flutamide is not recommended in patients whose ALT values exceed twice the upper limit of normal. (edyl.info)
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flutamide and bicalutamide) Progestogen drug. (modeway.tk)

Flutamide is a non-steroidal anti-androgen drug. (sigmaaldrich.com)
In the current work, a sustained drug delivery system of flutamide (FLT) was developed using chitosan (CS) and dextran sulphate (DS) nanoparticles and were characterized using different techniques. (amrita.edu)
This is not a complete list of flutamide drug interactions. (rxwiki.com)
Flutamide (FLT) is a non steroidal antiandrogenic drug used to treat prostate cancer. (amrita.edu)
Poly (vinyl alcohol) (PVA) coated flutamide nanoparticles (PVA FLT NPs) were formulated by nanoprecipitation method and characterized by DLS, TEM, FTIR, Drug release profile and biological assays. (amrita.edu)
Temerk Y, Ibrahim H (2015) Electrochemical studies and spectroscopic investigations on the interaction of an anticancer drug flutamide with DNA and its analytical applications. (springer.com)
Ahmadi F et al (2015) Synthesis of Ag nanoparticles for the electrochemical detection of anticancer drug flutamide. (springer.com)
Brahman PK et al (2012) Voltammetric determination of anticancer drug flutamide in surfactant media at polymer film modified carbon paste electrode. (springer.com)
Rezaeifar Z et al (2018) Electrochemical determination of anticancer drug, flutamide in human plasma sample using a microfabricated sensor based on hyperbranchedpolyglycerol modified graphene oxide reinforced hollow fiber-pencil graphite electrode. (springer.com)
Karthik R et al (2017) A facile graphene oxide based sensor for electrochemical detection of prostate anti-cancer (anti-testosterone) drug flutamide in biological samples. (springer.com)
El-Shanawany A et al (2014) Electrochemical characterization and determination of the anticancer drug, flutamide by cyclic voltammetry. (springer.com)
São Paulo, Brazil - Contrary to foregoing reports of significantside effects and high cost, Denise Steiner, M.D., Ph.D., contends that theanti-androgen drug flutamide 250 mg (Euflex, Euflexin) is a safe and effectivetherapy for treating female acne and androgenetic alopecia with an overallpositive relation of cost to benefit. (dermatologytimes.com)
Flutamide is used in combination with another prostate cancer drug. (emedtv.com)
Warnings and precautions side effects and adverse reactions drug interactions, overdosage flutamide + goserelin acetate implant + radiation versus radiation alone. (ypejexilu.ru)
Flutamide is a drug that blocks the action of testosterone on the prostate gland. (ypejexilu.ru)
Flutamide is a type of hormone drug called an anti androgen. (storysteel.ml)
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Se ha estimado que el PCOS afecta de 5 a 10% de las mujeres en este grupo de edad.Flutamide is a non-steroidal anti-androgenic drug, commonly used in the treatment of advanced prostate cancer, acne and hirsutism. (lsrfinancial.ga)
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Flutamide is used in combination with a gonadotropin-releasing hormone (GnRH) agonist medicine (sometimes called a luteinizing hormone-releasing hormone agonist). (emedtv.com)

Therefore, the current study was performed to determine whether late gestational or neonatal exposure to flutamide influences proliferation and apoptosis rates in large antral follicles of adult porcine ovary. (unboundmedicine.com)
Therefore, this study was performed to determine whether gestational or neonatal exposure to the anti-androgen flutamide influences androgen-dependent AQP5 expression in pre-antral and large antral follicles of adult pigs. (unboundmedicine.com)

Your doctor will order certain blood tests to check how well your liver is working before you begin taking flutamide, every month for the first 4 months of your treatment, and periodically for as long as your treatment continues. (medlineplus.gov)
For Stage B 2 to C prostate cancer, flutamide treatment (and goserelin) should start 8 weeks prior to initiating radiation therapy and continue during radiation therapy. (drugs.com)
Flutamide is used in the treatment of prostate cancers, which are dependent on testosterone for growth control. (cancerquest.org)
By blocking the growth enhancing actvities of testosterone in cancerous cells treatment with flutamide can result in a decrease in tumor size or a delay in tumor growth. (cancerquest.org)
Though very rare, there is a chance that liver toxicity can occur during treatment with flutamide. (cancerquest.org)
It is recommended you get blood tests: before starting treatment with flutamide, every month for the first 4 months of treatment, and periodically after the first 4 months. (uofmhealth.org)
At the end of treatment with flutamide or placebo, participants will have the option of receiving treatment with sertraline, an antidepressant known to be effective for many women with PMDD. (clinicaltrials.gov)
However, no studies have compared enzalutamide without AAT with enzalutamide after AAT with flutamide as treatment for castration-resistant prostate cancer (CRPC). (springer.com)
Analysis of androgen receptor and RNA polymerase II binding to the endogenous PSA gene by chromatin immunoprecipitation revealed that flutamide treatment and androgen withdrawal have different molecular mechanisms. (aacrjournals.org)
0.001) follicles following flutamide treatment. (unboundmedicine.com)
TY - JOUR T1 - Effect of Prenatal and Neonatal Anti-Androgen Flutamide Treatment on Aquaporin 5 Expression in the Adult Porcine Ovary. (unboundmedicine.com)
In contrast, treatment with low-dose flutamide?metformin did not increase body adiposity and did not alter follistatinemia detectably. (biomedsearch.com)
Finally, combined treatment with ethinylestradiol?drospirenone and flutamide?metformin was accompanied by an intermediate (2- to 3-fold) rise of follistatinemia (P? (biomedsearch.com)
Your doctor will need to monitor your liver function with blood tests before starting treatment with flutamide, every month for the first 4 months of treatment, and periodically thereafter. (speranta.tv)
For it must be remembered that the outwards of the treatment are far demonstrable upon their cattle for their many flutamide overnight delivery completely are the ubi of the lower particles, although the forms of it are equally more usual. (ouzel.com)
In these studies, men with prostate cancer that had not yet metastasized (had not widely spread) who received flutamide in combination with another prostate cancer medicine ( Zoladex ® ) prior to and during radiation treatment had a lower risk of treatment failure than men who received only radiation treatment. (emedtv.com)
Flutamide is indicated for the treatment of advanced prostatic carcinoma in which suppression of testosterone. (ypejexilu.ru)
Flutamide prostate cancer treatment side effect reversible can. (akm-freiburg.tk)
Treatment with ZOLADEX and flutamide should start 8 weeks prior to initiating radiation therapy and continue during. (akm-freiburg.tk)
Low-dose flutamide in the treatment of hyperandrogenism in. (akm-freiburg.tk)
flutamide is a nonsteroidal androgen receptor blocker approved for the treatment of prostate cancer. (access2emma.tk)
Serum transaminase levels should be measured prior to starting treatment with Flutamide. (edyl.info)
When angina occurs more frequently than once a day treatment zygomycetes flutamide 250 mg fast delivery, a chronic prophylactic regimen using -blockers as the first line of therapy should be considered (see. (technowhy.com)
Drink plenty of liquids while you are on flutamide treatment. (safegenericpharmacy.net)
Flutamide is used as chemotherapy for the treatment of cancers. (safegenericpharmacy.net)

Although flutamide is not for use by women, this medicine can cause birth defects if a woman is exposed to it during pregnancy. (uofmhealth.org)
Flutamide is in the FDA pregnancy category D. This means that it is known to harm an unborn baby. (speranta.tv)
When used by women during pregnancy, flutamide may harm the fetus. (healthpluspharmacy.com)
Q. Is flutamide safe during pregnancy? (safegenericpharmacy.net)

The single dose of flutamide ordinarily associated with symptoms of overdose or considered to be life-threatening has not been established. (edyl.info)

Fujikawa K, Matsui Y, Fukuzawa S et al (2000) Prostate-specific antigen levels and clinical response to flutamide as the second hormone therapy for hormone-refractory prostate carcinoma. (springer.com)
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Hospitalization and rarely death have been reported due to hepatic failure associated with flutamide use. (medscape.com)

Flutamide is used to treat prostate cancer in various stages. (cancerquest.org)
Flutamide is taken with other medicines to treat prostate cancer. (stlukes-stl.com)
Flutamide is used either alone or in combination to treat prostate cancer. (safegenericpharmacy.net)
Flutamide is also used to treat prostate cancer which has spread to other parts of the body (advanced cancer). (safegenericpharmacy.net)

tell your doctor and pharmacist if you are allergic to flutamide or any other medications. (medlineplus.gov)
You should not use flutamide if you are allergic to it, or if you have severe liver problems. (uofmhealth.org)
You should not use this medicine if you are allergic to flutamide. (wellspan.org)
You should not use this medicine if you have had had an allergic reaction to flutamide, or if you have severe liver disease. (stlukes-stl.com)

Flutamide may cause liver damage that can be serious or life-threatening. (medlineplus.gov)
Flutamide can cause serious liver problems. (uofmhealth.org)
You will need frequent blood tests to check your liver function while you are taking flutamide. (wellspan.org)
Some men taking flutamide had liver injury and needed to be hospitalized. (rxwiki.com)
In rare cases, men died because of liver failure while they were taking flutamide. (rxwiki.com)
In about half of these cases, the liver failure occurred in the first 3 months that they were taking flutamide. (rxwiki.com)
Because the flutamide product may cause liver failure, it is very important that you have all blood tests recommended by your doctor. (rxwiki.com)
Our previous study demonstrated that arylacetamide deacetylase (AADAC), one of the major serine esterases expressed in the human liver and gastrointestinal tract, catalyzes the flutamide hydrolysis. (aspetjournals.org)
In the inhibition assay, the flutamide hydrolase activities at a flutamide concentration of 5 μM in human liver and jejunum microsomes were strongly inhibited by a selective CES2 inhibitor, 10 μM loperamide, with the residual activities of 22.9 ± 3.5 and 18.6 ± 0.7%, respectively. (aspetjournals.org)
In rare cases, flutamide has caused severe liver damage resulting in death or hospitalization. (speranta.tv)
Flutamide is frequently associated with minor serum aminotransferase elevations and has been linked to numerous cases of acute liver injury, which are frequently severe and can be fatal. (storysteel.cf)
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Temerk YM, Ibrahim HS, Schuhmann W (2016) Square wave cathodic adsorptive stripping voltammetric determination of the anticancer drugs flutamide and irinotecan in biological fluids using renewable pencil graphite electrodes. (springer.com)

Flutamide works by blocking the actions of androgens, thereby slowing down the growth of prostate cancer cells. (emedtv.com)

Flutamide is a tablet. (storysteel.ml)
Cytomid 250mg tablet is a contain Flutamide as an active component. (safegenericpharmacy.net)

Johnson DB, Sonthalia S (2019) Flutamide. (springer.com)

The aims of this study are to introduce nanoformulation of flutamide to increase its aqueous solubility thereby improves the therapeutic efficacy of the chemodrug. (amrita.edu)

Schering-Plough manufactures Flutamide. (healthpluspharmacy.com)

Pecková K et al (2012) Voltammetric determination of flutamide and its metabolite 4-nitro-3-trifluoromethylaniline at a hanging mercury drop minielectrode. (springer.com)
Flutamide and its active metabolite were not well dialyzed. (edyl.info)
Preclinical data from rats, cats, dogs, and monkeys, as well as clinical data in men, demonstrate that one metabolite of flutamide is 4-nitro-3-fluoromethylaniline. (edyl.info)

In a previous trial, we found that adding the antiandrogen flutamide to leuprolide acetate (a synthetic gonadotropin-releasing hormone that results in medical ablation of testicular function) significantly improved survival as compared with that achieved with placebo plus leuprolide acetate. (nih.gov)
Men given the flutamide-plus-leuprolide combination survived an average of 34.9 months, compared with 27.9 months for men given leuprolide without flutamide. (emedtv.com)

The antiandrogenic effect of flutamide improves uterine perfusion in women with polycystic ovary syndrome. (curehunter.com)

Yes, flutamide lowers testosterone levels and blocks testosterone from reaching the cancer cells, thereby slowing the growth and of cancer cells. (safegenericpharmacy.net)

Other drugs may affect flutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. (uofmhealth.org)
Other drugs may interact with flutamide, including prescription and over-the-counter medicines, vitamins, and herbal products. (wellspan.org)
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The PVA coated flutamide nanoparticles were monodispersed and polycrystalline. (amrita.edu)
In the current study, a novel electrochemical sensor was constructed based on gold nanoparticles modified glassy carbon electrode (AuNPs/GCE) to detect Flutamide. (springer.com)

Anatomy4

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Pharmacokinetics of flutamide in patients with renal insufficiency. (1/384)

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. (2/384)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (3/384)

Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats. (4/384)

Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. (5/384)

Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay. (6/384)

Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. (7/384)

Combined treatment with the 5 alpha-reductase inhibitor PNU 157706 and the antiandrogen flutamide on the Dunning R3327 prostatic carcinoma in rats. (8/384)

Flutamide

Androgen Antagonists

Androgens

Genitalia, Male

Testosterone

Dihydrotestosterone

Androgen Receptor Antagonists

Receptors, Androgen

Orchiectomy

Metestrus

Anilides

Methyltestosterone

Antineoplastic Agents, Hormonal

Prostate

Hyaenidae

Tosyl Compounds

Hyperandrogenism

Linuron

Prostatic Neoplasms

Cytochrome P-450 CYP1A2

Cryptorchidism

Indiana

Georgia

Nerve Regeneration

Sciatic Nerve

Physical Conditioning, Animal

Prostate-Specific Antigen

Neoplasm Metastasis

Library Services

Libraries, Medical

Polycystic Ovary Syndrome

Metformin

Hirsutism

Patient Access to Records

Ovary

Electronic Mail

Food Dispensers, Automatic

Editorial Policies

Authorship

Periodicals as Topic

Postal Service

Internet

Neoplasms, Hormone-Dependent

Economics, Nursing

Lactation

Algorithms

Health Care Costs

Pharmacokinetics of flutamide in patients with renal insufficiency. (1/384)

From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. (2/384)

Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. (3/384)

Pharmacokinetics of flutamide and its metabolite 2-hydroxyflutamide in normal and hepatic injury rats. (4/384)

Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. (5/384)

Detection of the environmental antiandrogen p,p-DDE in CD and long-evans rats using a tier I screening battery and a Hershberger assay. (6/384)

Testosterone signaling through internalizable surface receptors in androgen receptor-free macrophages. (7/384)

Combined treatment with the 5 alpha-reductase inhibitor PNU 157706 and the antiandrogen flutamide on the Dunning R3327 prostatic carcinoma in rats. (8/384)

Exploring the antiperoxidative potential of morin on cyclophosphamide and flutamide-induced lipid peroxidation and changes in...

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Anti-androgen flutamide suppresses hepatocellular carcinoma cell proliferation via the aryl hydrocarbon receptor mediated...

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