Benzodiazepines
Secobarbital
GABA Modulators
Anti-Anxiety Agents
Hypnotics and Sedatives
Triazolam
Lorazepam
Diazepam
Receptors, GABA-A
Pentobarbital
Anaesthetic effects of pregnanolone in combination with allopregnanolone, thiopental, hexobarbital and flurazepam: an EEG study in the rat. (1/62)
The anaesthetic interactions of the steroid, 3 alpha-hydroxy-5 beta-pregnan-20-one, in male rats were investigated in different fixed binary combinations with the steroid allopregnanolone (3 alpha-hydroxy-5 alpha-pregnan-20-one), two barbiturates (thiopental and hexobarbital) and the benzodiazepine, flurazepam. Anaesthetic effects were determined using an EEG threshold method. Interactions were assessed using an isobolographic method. The interaction between the two steroids, pregnanolone and allopregnanolone, showed an anaesthetic effect significantly less than additive (antagonistic). The interactions between pregnanolone and the two barbiturates and the benzodiazepine showed an anaesthetic effect significantly greater than additive (potentiation) in all tests performed. These results could be explained by a pharmacodynamic interaction at the hypothetical GABA-benzodiazepine-barbiturate-steroid complex in the CNS. (+info)GABA receptors inhibited by benzodiazepines mediate fast inhibitory transmission in the central amygdala. (2/62)
The amygdala is intimately involved in emotional behavior, and its role in the generation of anxiety and conditioned fear is well known. Benzodiazepines, which are commonly used for the relief of anxiety, are thought to act by enhancing the action of the inhibitory transmitter GABA. We have examined the properties of GABA-mediated inhibition in the amygdala. Whole-cell recordings were made from neurons in the lateral division of the central amygdala. Application of GABA evoked a current that reversed at the chloride equilibrium potential. Application of the GABA antagonists bicuculline or SR95531 inhibited the GABA-evoked current in a manner consistent with two binding sites. Stimulation of afferents to neurons in the central amygdala evoked an IPSC that was mediated by the release of GABA. The GABA(A) receptor antagonists bicuculline and picrotoxin failed to completely block the IPSC. The bicuculline-resistant IPSC was chloride-selective and was unaffected by GABA(B)-receptor antagonists. Furthermore, this current was insensitive to modulation by general anesthetics or barbiturates. In contrast to their actions at GABA(A) receptors, diazepam and flurazepam inhibited the bicuculline-resistant IPSC in a concentration-dependent manner. These effects were fully antagonized by the benzodiazepine site antagonist Ro15-1788. We conclude that a new type of ionotropic GABA receptor mediates fast inhibitory transmission in the central amygdala. This receptor may be a potential target for the development of new therapeutic strategies for anxiety disorders. (+info)Antagonist-induced reversal of functional and structural measures of hippocampal benzodiazepine tolerance. (3/62)
One week oral flurazepam (FZP) administration in rats results in anticonvulsant tolerance in vivo, tolerance measured in vitro in hippocampal CA1 pyramidal cells, and regulation of hippocampal gamma-aminobutyric acid(A)-receptor subunit protein expression. A single injection (4 or 20 mg/kg i.p) of the benzodiazepine antagonist flumazenil (FLM) was given 1 day after FZP treatment, and tolerance and subunit protein expression were evaluated 1 day later. In vivo tolerance was measured by a reduced ability of the alpha(1)-subunit-selective agonist zolpidem to suppress pentylenetetrazole-induced seizures. This tolerance was reversed by 20 but not 4 mg/kg FLM. In in vitro hippocampal slices, there was tolerance to the effect of zolpidem to prolong the decay of pyramidal cell miniature inhibitory postsynaptic currents, which was reversed by FLM (4 mg/kg) pretreatment. A reduction in miniature inhibitory postsynaptic current amplitude ( approximately 50%) was also restored by FLM injection. [(3)H]Zolpidem binding measured 0, 2, and 7 days after FZP treatment was significantly decreased in the hippocampus and cortex at 0 days but not thereafter. Changes in alpha(1)- and beta(3)-subunit protein expression were examined via quantitative immunohistochemical techniques. alpha(1)-Subunit protein levels were down-regulated in the CA1 stratum oriens and beta subunit levels were up-regulated in the stratum oriens and stratum radiatum of the CA3 region. Chronic FZP effects on alpha(1)- and beta(3)-subunit protein levels were also reversed by prior FLM injection. FLM's effect on both functional and structural correlates of benzodiazepine tolerance suggests that each of these measures plays an interdependent role in mediating benzodiazepine tolerance. (+info)Comparison of the residual effects of two benzodiazepines (nitrazepam and flurazepam hydrochloride) and pentobarbitone sodium on human performance. (4/62)
1 The residual effects of two benzodiazepines, nitrazepam (10 mg) and flurazepam hydrochloride (30 mg), and pentobarbitone sodium (200 mg) were studied by adaptive tracking and by reaction time. Performance was measured at 10 h, 13 h, 16 h, 19 h and 34 h after ingestion of each drug. Impaired performance on adaptive tracking was observed at 10 h, 13 h, 16 h and 19 h after nitrazepam and pentobarbitone sodium and at 10 h, 13 h and 16 h after flurazepam hydrochloride. Enhanced performance was observed at 34 h after nitrazepam and pentobarbitone sodium. 2 Increased reaction time persisted to 16 h after nitrazepam, flurazepam hydrochloride and pentobarbitone sodium and reaction time was also increased at 34 h after nitrazepam and pentobarbitone sodium. 3 During the morning immediately after ingestion, the subjects as a group were able to differentiate correctly between placebo and drugs, but they were not able to assess accurately the persistence of the residual effects of nitrazepam and pentobarbitone sodium. 4 Flurazepam hydrochloride would appear to be a more promising benzodiazepine than nitrazepam for use as a hypnotic by persons involved in skilled activity. There was a rapid recovery of performance during the afternoon and, unlike pentobarbitone sodium and nitrazepam, subjects retained the ability to recognize impaired skill. (+info)A clinical and psychometric evaluation of flurazepam. (5/62)
1 The efficacy of flurazepam (15 mg or 30 mg) as a hypnotic, and the residual effects of each dose were compared with placebo in a double-blind cross-over trial involving thirty patients in a general practice setting. Patients received each medication for one week. Daily self-ratings of onset, duration and quality of sleep, together with reports of any untoward effects were made. At the end of each period of medication psychomotor tests (reaction time, pursuit rotor, tapping speed) were administered at 09.00 hours. 2 Both doses of flurazepam were significantly more effective than placebo in inducing sleep, improving the quality of sleep and extending its duration. 3 'Hangover' effects were marked following 30 mg, but not after flurazepam (15 mg). Flurazepam (30 mg, but not 15 mg) significantly impaired performance on the pursuit rotor test and tapping speed. Flurazepam thus appears to be an effective hypnotic drug with the optimum dose for use in general practice being 15 mg at night. (+info)Down-regulation of benzodiazepine binding to alpha 5 subunit-containing gamma-aminobutyric Acid(A) receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region. (6/62)
Chronic benzodiazepine treatment can produce tolerance and changes in gamma-aminobutyric acid (GABA)(A) receptors. To study the effect of treatment on a selected population of receptors, assays were performed using [(3)H]RY-80, which is selective for GABA(A) receptors with an alpha 5 subunit. Rats were given a flurazepam treatment known to produce tolerance and down-regulation of benzodiazepine binding, or a diazepam treatment shown to produce tolerance but not receptor down-regulation. Quantitative receptor autoradiography using sagittal brain sections bound with [(3)H]RY-80 showed binding in areas known to express alpha 5 mRNA. Brains from flurazepam-treated rats showed significantly decreased 1 nM [(3)H]RY-80 binding in hippocampal formation (e.g., 32% decrease in CA1) and superior colliculus, but not other areas. Using 5 nM [(3)H]RY-80 showed similar decreases in hippocampus. A corresponding 29% decrease in B(max) but no change in K(d) was found with a filtration binding assay using hippocampal homogenates. Down-regulation of [(3)H]RY-80 binding had returned to control by 2 days after withdrawing flurazepam treatment. The magnitude of down-regulation of [(3)H]RY-80 binding suggested that GABA(A) receptors with an alpha 5 subunit may play a prominent role in the adaptive responses associated with benzodiazepine tolerance. Chronic diazepam treatment also resulted in decreased [(3)H]RY-80 binding. However, the regional selectivity was even more pronounced than in flurazepam-treated rats, and only the hippocampal CA1 region showed decreased binding (27%). This localized down-regulation persisted for several days after the end of diazepam treatment. These data indicate that synapses in the hippocampal CA1 region are particularly involved in the adaptive response to chronic benzodiazepine treatments. (+info)Fatal self-poisoning with lithium carbonate. (7/62)
In a fatal case of self-poisoning with lithium carbonate there was a progressive increase in serum lithium concentration for 48 hours after ingestion of the overdose. It is suggested that the continuous increase in serum lithium concentration reflects prolonged absorption of lithium from relatively insoluble aggregates of lithium carbonate in the gastrointestinal tract. In this case there was an interval of 45 hours between ingestion of the overdose and the onset of central nervous system depression. Simultaneous peritoneal dialysis and hemodialysis were effective in rapidly reducing the serum lithium concentration but there was little concomitant change in the patient's level of consciousness. The terminal event was a respiratory complication of the comatose state. (+info)Effect of nitrazepam and flurazepam on the ventilatory response to carbon dioxide. (8/62)
Ventilatory response to CO2 was measured before and after two different benzodiazepine hypnotics in both chronic bronchitics and patients without chest disease. Flurazepam, but not nitrazepam, produced a significant decrease in CO2 sensitivity, although there was no significant change in FEV1 or mixed venous PCO2. This is the first unequivocal evidence of central depression of respiration by a benzodiazepine and may be the mechanism by which benzodiazepines cause deterioration in patients with respiratory failure. (+info)Flurazepam is a benzodiazepine medication that is primarily used for the treatment of insomnia. According to the Medical Dictionary by Farlex, Flurazepam's medical definition is: "A long-acting benzodiazepine used in the management of severe insomnia. It has a rapid onset of action and produces sedation, anxiolysis, and muscle relaxation."
Flurazepam works by enhancing the effects of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits the activity of neurons in the brain. This results in calming effects on the central nervous system, helping to reduce anxiety and promote sleep. It is essential to use Flurazepam under the guidance of a healthcare professional due to its potential for dependency and side effects such as drowsiness, dizziness, and impaired coordination.
Nitrazepam is a benzodiazepine drug primarily used for the treatment of severe insomnia and sometimes for managing certain types of epilepsy. It works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits central nervous system activity, thereby producing calming effects.
According to the World Health Organization's (WHO) Anatomical Therapeutic Chemical (ATC) classification system, Nitrazepam falls under the category of "N05CD - Benzodiazepine derivatives" and has the ATC code "N05CD02".
It is essential to note that Nitrazepam should only be used under medical supervision due to its potential for dependence, addiction, and other side effects. It is also not recommended for long-term use or in pregnant or breastfeeding women without consulting a healthcare professional first.
Temazepam is a benzodiazepine medication that is primarily used for the treatment of insomnia. It has a depressant effect on the central nervous system and helps to slow down brain activity, allowing for relaxation and promoting sleep. Temazepam works by binding to specific receptors in the brain called GABA-A receptors, which are involved in regulating nerve impulses in the brain. This action increases the activity of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA), resulting in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant effects.
Temazepam is available in immediate-release and controlled-release formulations, with the former typically taken just before bedtime and the latter taken at bedtime to help people stay asleep throughout the night. It is important to note that temazepam can be habit-forming and should only be used under the supervision of a healthcare provider. Common side effects include drowsiness, dizziness, weakness, and coordination problems.
Benzodiazepines are a class of psychoactive drugs that have been widely used for their sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties. They act by enhancing the inhibitory effects of gamma-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system.
Benzodiazepines are commonly prescribed for the treatment of anxiety disorders, insomnia, seizures, and muscle spasms. They can also be used as premedication before medical procedures to produce sedation, amnesia, and anxiolysis. Some examples of benzodiazepines include diazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), lorazepam (Ativan), and temazepam (Restoril).
While benzodiazepines are effective in treating various medical conditions, they can also cause physical dependence and withdrawal symptoms. Long-term use of benzodiazepines can lead to tolerance, meaning that higher doses are needed to achieve the same effect. Abrupt discontinuation of benzodiazepines can result in severe withdrawal symptoms, including seizures, hallucinations, and anxiety. Therefore, it is important to taper off benzodiazepines gradually under medical supervision.
Benzodiazepines are classified as Schedule IV controlled substances in the United States due to their potential for abuse and dependence. It is essential to use them only as directed by a healthcare provider and to be aware of their potential risks and benefits.
Secobarbital is a barbiturate medication that is primarily used for the treatment of short-term insomnia and as a preoperative sedative. It works by depressing the central nervous system, producing a calming effect and helping to induce sleep. Secobarbital has a rapid onset of action and a relatively short duration of effect.
It is available in various forms, including capsules and injectable solutions, and is typically prescribed for use on an as-needed basis rather than as a regular medication. Secobarbital can be habit-forming and carries a risk of dependence and withdrawal, so it should only be used under the close supervision of a healthcare provider.
It's important to note that Secobarbital is not commonly prescribed in modern medical practice due to its high potential for abuse and the availability of safer and more effective sleep aids.
GABA (gamma-aminobutyric acid) modulators are substances that affect the function of GABA, which is the primary inhibitory neurotransmitter in the central nervous system. GABA plays a crucial role in regulating neuronal excitability and reducing the activity of overactive nerve cells.
GABA modulators can either enhance or decrease the activity of GABA receptors, depending on their specific mechanism of action. These substances can be classified into two main categories:
1. Positive allosteric modulators (PAMs): These compounds bind to a site on the GABA receptor that is distinct from the neurotransmitter binding site and enhance the activity of GABA at the receptor, leading to increased inhibitory signaling in the brain. Examples of positive allosteric modulators include benzodiazepines, barbiturates, and certain non-benzodiazepine drugs used for anxiolysis, sedation, and muscle relaxation.
2. Negative allosteric modulators (NAMs): These compounds bind to a site on the GABA receptor that reduces the activity of GABA at the receptor, leading to decreased inhibitory signaling in the brain. Examples of negative allosteric modulators include certain antiepileptic drugs and alcohol, which can reduce the effectiveness of GABA-mediated inhibition and contribute to their proconvulsant effects.
It is important to note that while GABA modulators can have therapeutic benefits in treating various neurological and psychiatric conditions, they can also carry risks for abuse, dependence, and adverse side effects, particularly when used at high doses or over extended periods.
Anti-anxiety agents, also known as anxiolytics, are a class of medications used to manage symptoms of anxiety disorders. These drugs work by reducing the abnormal excitement in the brain and promoting relaxation and calmness. They include several types of medications such as benzodiazepines, azapirone, antihistamines, and beta-blockers.
Benzodiazepines are the most commonly prescribed anti-anxiety agents. They work by enhancing the inhibitory effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which results in sedative, hypnotic, anxiolytic, anticonvulsant, and muscle relaxant properties. Examples of benzodiazepines include diazepam (Valium), alprazolam (Xanax), lorazepam (Ativan), and clonazepam (Klonopin).
Azapirones are a newer class of anti-anxiety agents that act on serotonin receptors in the brain. Buspirone (Buspar) is an example of this type of medication, which has fewer side effects and less potential for abuse compared to benzodiazepines.
Antihistamines are medications that are primarily used to treat allergies but can also have anti-anxiety effects due to their sedative properties. Examples include hydroxyzine (Vistaril, Atarax) and diphenhydramine (Benadryl).
Beta-blockers are mainly used to treat high blood pressure and heart conditions but can also help manage symptoms of anxiety such as rapid heartbeat, tremors, and sweating. Propranolol (Inderal) is an example of a beta-blocker used for this purpose.
It's important to note that anti-anxiety agents should be used under the guidance of a healthcare professional, as they can have side effects and potential for dependence or addiction. Additionally, these medications are often used in combination with psychotherapy and lifestyle modifications to manage anxiety disorders effectively.
Hypnotics and sedatives are classes of medications that have depressant effects on the central nervous system, leading to sedation (calming or inducing sleep), reduction in anxiety, and in some cases, decreased awareness or memory. These agents work by affecting the neurotransmitter GABA (gamma-aminobutyric acid) in the brain, which results in inhibitory effects on neuronal activity.
Hypnotics are primarily used for the treatment of insomnia and other sleep disorders, while sedatives are often prescribed to manage anxiety or to produce a calming effect before medical procedures. Some medications can function as both hypnotics and sedatives, depending on the dosage and specific formulation. Common examples of these medications include benzodiazepines (such as diazepam and lorazepam), non-benzodiazepine hypnotics (such as zolpidem and eszopiclone), barbiturates, and certain antihistamines.
It is essential to use these medications under the guidance of a healthcare professional, as they can have potential side effects, such as drowsiness, dizziness, confusion, and impaired coordination. Additionally, long-term use or high doses may lead to tolerance, dependence, and withdrawal symptoms upon discontinuation.
Triazolam is a short-acting benzodiazepine drug, which is primarily used for the treatment of insomnia. It works by increasing the activity of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits the activity of neurons in the brain, thereby producing a calming effect. Triazolam has a rapid onset of action and its effects typically last for 1-2 hours, making it useful for inducing sleep. However, due to its short duration of action and potential for dependence and tolerance, triazolam is generally recommended for short-term use only.
Like all benzodiazepines, triazolam carries a risk of serious side effects, including respiratory depression, physical dependence, and cognitive impairment. It should be used with caution and under the close supervision of a healthcare provider.
Lorazepam is a medication that belongs to a class of drugs known as benzodiazepines. Medically, it is defined as a prescription drug used for the treatment of anxiety disorders, short-term relief of symptoms of anxiety or anxiety associated with depressive symptoms. It can also be used for the treatment of insomnia, seizure disorders, and alcohol withdrawal. Lorazepam works by affecting chemicals in the brain that may become unbalanced and cause anxiety or other symptoms.
It is important to note that lorazepam can be habit-forming and should only be used under the supervision of a healthcare provider. Misuse of this medication can lead to serious risks, including addiction, overdose, or death.
Diazepam is a medication from the benzodiazepine class, which typically has calming, sedative, muscle relaxant, and anticonvulsant properties. Its medical uses include the treatment of anxiety disorders, alcohol withdrawal syndrome, end-of-life sedation, seizures, muscle spasms, and as a premedication for medical procedures. Diazepam is available in various forms, such as tablets, oral solution, rectal gel, and injectable solutions. It works by enhancing the effects of a neurotransmitter called gamma-aminobutyric acid (GABA) in the brain, which results in the modulation of nerve impulses in the brain, producing a sedative effect.
It is important to note that diazepam can be habit-forming and has several potential side effects, including drowsiness, dizziness, weakness, and impaired coordination. It should only be used under the supervision of a healthcare professional and according to the prescribed dosage to minimize the risk of adverse effects and dependence.
GABA-A receptors are ligand-gated ion channels in the membrane of neuronal cells. They are the primary mediators of fast inhibitory synaptic transmission in the central nervous system. When the neurotransmitter gamma-aminobutyric acid (GABA) binds to these receptors, it opens an ion channel that allows chloride ions to flow into the neuron, resulting in hyperpolarization of the membrane and decreased excitability of the neuron. This inhibitory effect helps to regulate neural activity and maintain a balance between excitation and inhibition in the nervous system. GABA-A receptors are composed of multiple subunits, and the specific combination of subunits can determine the receptor's properties, such as its sensitivity to different drugs or neurotransmitters.
Pentobarbital is a barbiturate medication that is primarily used for its sedative and hypnotic effects in the treatment of insomnia, seizure disorders, and occasionally to treat severe agitation or delirium. It works by decreasing the activity of nerves in the brain, which produces a calming effect.
In addition to its medical uses, pentobarbital has been used for non-therapeutic purposes such as euthanasia and capital punishment due to its ability to cause respiratory depression and death when given in high doses. It is important to note that the use of pentobarbital for these purposes is highly regulated and restricted to licensed medical professionals in specific circumstances.
Like all barbiturates, pentobarbital has a high potential for abuse and addiction, and its use should be closely monitored by a healthcare provider. It can also cause serious side effects such as respiratory depression, decreased heart rate, and low blood pressure, especially when used in large doses or combined with other central nervous system depressants.
Flumazenil is a medication that acts as a competitive antagonist at benzodiazepine receptors. It is primarily used in clinical settings to reverse the effects of benzodiazepines, which are commonly prescribed for their sedative, muscle relaxant, and anxiety-reducing properties. Flumazenil can reverse symptoms such as excessive sedation, respiratory depression, and impaired consciousness caused by benzodiazepine overdose or adverse reactions. It is important to note that flumazenil should be administered with caution, as it can precipitate seizures in individuals who are physically dependent on benzodiazepines.
Flurazepam
Biological half-life
Roche
Benzodiazepine withdrawal syndrome
Benzodiazepine
Quazepam
Rebound effect
Dorothea Puente
Estazolam
Lorazepam
List of Schedule IV controlled substances (U.S.)
Lopirazepam
Clorazepate
Î’-Carboline
Diazepam
Fludiazepam
Death of Cindy James
Fosazepam
Temazepam
Flualprazolam
Flutazolam
Chlordiazepoxide
Benzodiazepine dependence
Nitrazepam
Zopiclone
Benzodiazepine use disorder
N-Desalkylflurazepam
Flutoprazepam
Leo Sternbach
Honokiol
Flurazepam - Wikipedia
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Insomnia treatments and medications
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Estazolam1
- Flurazepam, temazepam, quazepam, estazolam, and triazolam are the benzodiazepines that are approved by the US Food and Drug Administration (FDA) as hypnotics. (medscape.com)
Dalmane4
- Flurazepam (marketed under the brand names Dalmane and Dalmadorm) is a drug which is a benzodiazepine derivative. (wikipedia.org)
- Dalmane (generic name flurazepam) is prescribed to manage insomnia. (vipvorobjev.com)
- A reduced rate of lidocaine metabolism following tumescent liposuction may result from an inhibition of cytochrome P450 3A4 (CYP3A4) by sertraline (Zoloft) and flurazepam (Dalmane). (liposuction.com)
- Perioperative sedation on this occasion of 30 mg PO of flurazepam (Dalmane), instead of the zolpidem that was used for the first surgery. (liposuction.com)
Triazolam1
- Reeves R. Comparison of triazolam, flurazepam, and placebo as hypnotics in geriatric patients with insomnia. (bmj.com)
Temazepam1
- Flurazepam is a long-acting benzodiazepine and is sometimes used in patients who have difficulty in maintaining sleep, though benzodiazepines with intermediate half-lives such as loprazolam, lormetazepam, and temazepam are also indicated for patients with difficulty maintaining sleep. (wikipedia.org)
Insomnia5
- Flurazepam is officially indicated for mild to moderate insomnia and as such it is used for short-term treatment of patients with mild to moderate insomnia such as difficulty falling asleep, frequent awakening, early awakenings or a combination of each. (wikipedia.org)
- A review paper found that long-term use of flurazepam is associated with drug tolerance, drug dependence, rebound insomnia and central nervous system (CNS) related adverse effects. (wikipedia.org)
- Flurazepam is used to treat insomnia (difficulty falling asleep and staying asleep). (medlineplus.gov)
- Flurazepam is frequently chosen as a short-term treatment of insomnia. (medscape.com)
- Flurazepam is used to treat insomnia. (vipvorobjev.com)
Capsule2
- Flurazepam comes as a capsule to take by mouth. (medlineplus.gov)
- Each hard gelatin, size 2 capsule, with orange opaque body and grey opaque cap, contains flurazepam hydrochloride 15 mg. (medbroadcast.com)
Class of medications called benzodiazepines2
- Flurazepam is in a class of medications called benzodiazepines. (medlineplus.gov)
- Flurazepam belongs to the class of medications called benzodiazepines. (pocketpills.com)
Allergic to flurazepam1
- tell your doctor and pharmacist if you are allergic to flurazepam, any other medications, or any of the ingredients in flurazepam capsules. (medlineplus.gov)
Benzodiazepines3
- Flurazepam and other benzodiazepines such as fosazepam, and nitrazepam lost some of their effect after seven days administration in psychogeriatric patients. (wikipedia.org)
- Flurazepam, similar to other benzodiazepines and nonbenzodiazepine hypnotic drugs causes impairments in body balance and standing steadiness in individuals who wake up at night or the next morning. (wikipedia.org)
- Compared with the benzodiazepines including flurazepam, the nonbenzodiazepine sedative-hypnotics appeared to offer few, if any, significant clinical advantages in efficacy in elderly persons. (wikipedia.org)
Benzodiazepine4
- After discontinuation of flurazepam a rebound effect or benzodiazepine withdrawal syndrome may occur about four days after discontinuation of medication. (wikipedia.org)
- Flurazepam (Nindral (15 mg)) is a benzodiazepine, prescribed for sleep disorder. (medindia.net)
- Norflurazepam (N-Desalkylflurazepam) is a new designer drug, benzodiazepine, an analogue of Flurazepam and is its metabolite. (rawpowdereu.com)
- Flurazepam is a medicine that is a benzodiazepine derivative. (painmedsupplier.com)
Medication3
- Flurazepam may cause a physical dependence (a condition in which unpleasant physical symptoms occur if a medication is suddenly stopped or taken in smaller doses), especially if you take it for several days to several weeks. (medlineplus.gov)
- You may continue to feel the effects of flurazepam for one to two nights after you stop taking the medication. (medlineplus.gov)
- Reliable manufacturer and supplier of Flurazepam Capsules and various health medication and research chemicals. (painmedsupplier.com)
Sedative1
- Flurazepam shares cross tolerance with barbiturates and barbiturates can easily be substituted by flurazepam in those who are habituated to barbiturate sedative hypnotics. (wikipedia.org)
Capsules1
- We are offering Flurazepam Capsules. (painmedsupplier.com)
Drugs2
- Drinking alcohol or using street drugs during your treatment with flurazepam also increases the risk that you will experience these serious, life-threatening side effects. (medlineplus.gov)
- Apomorphine, Tadalafil and Flurazepam are all different drugs of different category and do not point out to a single diagnosis. (doctorspring.com)
Fentanyl1
- fentanyl, flurazepam. (medscape.com)
Bedtime2
- Patients are prescribed to take flurazepam at bedtime and exactly as directed by the doctor. (vipvorobjev.com)
- The recommended adult dose of flurazepam ranges from 15 mg to 30 mg and is taken before bedtime. (pocketpills.com)
Medications3
- Flurazepam may increase the risk of serious or life-threatening breathing problems, sedation, or coma if used along with certain medications. (medlineplus.gov)
- If you take flurazepam with any of these medications and you develop any of the following symptoms, call your doctor immediately or seek emergency medical care immediately: unusual dizziness, lightheadedness, extreme sleepiness, slowed or difficult breathing, or unresponsiveness. (medlineplus.gov)
- You could get Bio Flurazepam delivered at your doorstep from us in Canada if you ordered prescription medications with a valid prescription. (pocketpills.com)
Sedation3
- benzhydrocodone/acetaminophen and flurazepam both increase sedation. (medscape.com)
- buprenorphine subdermal implant and flurazepam both increase sedation. (medscape.com)
- buprenorphine, long-acting injection and flurazepam both increase sedation. (medscape.com)
CYP3A42
- apalutamide will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
- enzalutamide will decrease the level or effect of flurazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. (medscape.com)
Hypnotics1
- Flurazepam, developed by Roche Pharmaceuticals was one of the first benzo hypnotics (sleeping pills) to be marketed. (wikipedia.org)
Metabolism1
- The specific cytochrome P450 enzyme responsible for the metabolism of flurazepam has not been identified. (liposuction.com)
Dose2
- Flurazepam is best used for a short time period and at the lowest possible dose to avoid complications associated with long-term use. (wikipedia.org)
- Your doctor probably will decrease your flurazepam dose gradually. (medlineplus.gov)
Products2
- Browse our extensive selection of high-quality Flurazepam products available in a range of purities and quantities to meet your research and development needs. (clearsynth.com)
- Explore our Flurazepam products and find the perfect solution for your needs. (clearsynth.com)
Treatment1
- This is a great treatment for patients battling chronic flurazepam addiction. (vipvorobjev.com)
Price1
- Mamelak M, Csima A, Buck L, Price V. A comparative study on the effects of brotizolam and flurazepam on sleep and performance in the elderly. (bmj.com)
Doctor5
- Your doctor may have suggested Bio Flurazepam for conditions other than the ones listed in these drug information articles. (pocketpills.com)
- If you have not discussed this with your doctor or are not sure why you are taking Bio Flurazepam, speak to your doctor. (pocketpills.com)
- Do not stop taking Bio Flurazepam without consulting your doctor. (pocketpills.com)
- Flurazepam should not be taken for longer than 7 to 10 consecutive days unless otherwise directed by your doctor. (pocketpills.com)
- If you are concerned about side effects, discuss the risks and benefits of Bio Flurazepam with your doctor. (pocketpills.com)
Effects2
- The side effects listed below are not experienced by everyone who takes Bio Flurazepam. (pocketpills.com)
- The following side effects have been reported by at least 1% of people taking Bio Flurazepam. (pocketpills.com)
Drug1
- Flurazepam can be habit-forming, leading to addictions and drug abuse. (vipvorobjev.com)
Abuse potential2
- Flurazepam has abuse potential and should never be used with alcoholic beverages or any other substance that can cause drowsiness. (wikipedia.org)
- Flurazepam is abenzo and is having an abuse potential. (doctorspring.com)
Days1
- Your sleep problems should improve within 7 to 10 days after you start taking flurazepam. (medlineplus.gov)
Find1
- Contact your provider or us to help you find out if you qualify to get Bio Flurazepam for free. (pocketpills.com)
Stop1
- Flurazepam starts working slowly and continues to work for a short time after you stop taking it. (medlineplus.gov)
Benefit1
- You may experience more benefit from flurazepam on the second and third nights after you start taking it. (medlineplus.gov)
Condition2
- Stopping flurazepam suddenly can worsen your condition and cause withdrawal symptoms that may last for several weeks to more than 12 months. (medlineplus.gov)
- Flurazepam addiction is a condition that cannot get better on its own, so it will worsen if left untreated. (vipvorobjev.com)
Health1
- You can get Bio Flurazepam for free in Canada if your health insurance provider covers it fully. (pocketpills.com)