The compound is given by intravenous injection to do POSITRON-EMISSION TOMOGRAPHY for the assessment of cerebral and myocardial glucose metabolism in various physiological or pathological states including stroke and myocardial ischemia. It is also employed for the detection of malignant tumors including those of the brain, liver, and thyroid gland. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1162)
An imaging technique using compounds labelled with short-lived positron-emitting radionuclides (such as carbon-11, nitrogen-13, oxygen-15 and fluorine-18) to measure cell metabolism. It has been useful in study of soft tissues such as CANCER; CARDIOVASCULAR SYSTEM; and brain. SINGLE-PHOTON EMISSION-COMPUTED TOMOGRAPHY is closely related to positron emission tomography, but uses isotopes with longer half-lives and resolution is lower.
Compounds that are used in medicine as sources of radiation for radiotherapy and for diagnostic purposes. They have numerous uses in research and industry. (Martindale, The Extra Pharmacopoeia, 30th ed, p1161)
Tomography using radioactive emissions from injected RADIONUCLIDES and computer ALGORITHMS to reconstruct an image.
Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.
2-Deoxy-D-arabino-hexose. An antimetabolite of glucose with antiviral activity.
The use of combination of imaging techniques or platforms (e.g., MRI SCAN and PET SCAN) encompassing aspects of anatomical, functional, or molecular imaging methods.
Tomography using x-ray transmission and a computer algorithm to reconstruct the image.
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.
The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.
In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.
The creation of a visual display of the inside of the entire body of a human or animal for the purposes of diagnostic evaluation. This is most commonly achieved by using MAGNETIC RESONANCE IMAGING; or POSITRON EMISSION TOMOGRAPHY.
A nonmetallic, diatomic gas that is a trace element and member of the halogen family. It is used in dentistry as flouride (FLUORIDES) to prevent dental caries.
Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.
Unstable isotopes of nitrogen that decay or disintegrate emitting radiation. N atoms with atomic weights 12, 13, 16, 17, and 18 are radioactive nitrogen isotopes.
Non-invasive method of demonstrating internal anatomy based on the principle that atomic nuclei in a strong magnetic field absorb pulses of radiofrequency energy and emit them as radiowaves which can be reconstructed into computerized images. The concept includes proton spin tomographic techniques.
Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.
The span of viability of a tissue or an organ.
Unstable isotopes of gallium that decay or disintegrate emitting radiation. Ga atoms with atomic weights 63-68, 70 and 72-76 are radioactive gallium isotopes.
Tumors or cancer of the LUNG.
A method of computed tomography that uses radionuclides which emit a single photon of a given energy. The camera is rotated 180 or 360 degrees around the patient to capture images at multiple positions along the arc. The computer is then used to reconstruct the transaxial, sagittal, and coronal images from the 3-dimensional distribution of radionuclides in the organ. The advantages of SPECT are that it can be used to observe biochemical and physiological processes as well as size and volume of the organ. The disadvantage is that, unlike positron-emission tomography where the positron-electron annihilation results in the emission of 2 photons at 180 degrees from each other, SPECT requires physical collimation to line up the photons, which results in the loss of many available photons and hence degrades the image.
Tumors or cancer of the MEDIASTINUM.
Electronic instruments that produce photographs or cathode-ray tube images of the gamma-ray emissions from organs containing radionuclide tracers.
INFLAMMATION of any ARTERIES.
Transfer of a neoplasm from its primary site to lymph nodes or to distant parts of the body by way of the lymphatic system.
Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.
Unstable isotopes of thallium that decay or disintegrate emitting radiation. Tl atoms with atomic weights 198-202, 204, and 206-210 are thallium radioisotopes.
A membrane in the midline of the THORAX of mammals. It separates the lungs between the STERNUM in front and the VERTEBRAL COLUMN behind. It also surrounds the HEART, TRACHEA, ESOPHAGUS, THYMUS, and LYMPH NODES.
A non-inherited congenital condition with vascular and neurological abnormalities. It is characterized by facial vascular nevi (PORT-WINE STAIN), and capillary angiomatosis of intracranial membranes (MENINGES; CHOROID). Neurological features include EPILEPSY; cognitive deficits; GLAUCOMA; and visual defects.
A plasmid whose presence in the cell, either extrachromosomal or integrated into the BACTERIAL CHROMOSOME, determines the "sex" of the bacterium, host chromosome mobilization, transfer via conjugation (CONJUGATION, GENETIC) of genetic material, and the formation of SEX PILI.
A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations.
A single lung lesion that is characterized by a small round mass of tissue, usually less than 1 cm in diameter, and can be detected by chest radiography. A solitary pulmonary nodule can be associated with neoplasm, tuberculosis, cyst, or other anomalies in the lung, the CHEST WALL, or the PLEURA.
A catecholamine derivative with specificity for BETA-1 ADRENERGIC RECEPTORS. It is commonly used as a cardiotonic agent after CARDIAC SURGERY and during DOBUTAMINE STRESS ECHOCARDIOGRAPHY.
A technique of inputting two-dimensional images into a computer and then enhancing or analyzing the imagery into a form that is more useful to the human observer.
The making of a radiograph of an object or tissue by recording on a photographic plate the radiation emitted by radioactive material within the object. (Dorland, 27th ed)
Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.
Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.
Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.
The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.
A nitroimidazole that sensitizes normally radio-resistant hypoxic cells to radiation. It may also be directly cytotoxic to hypoxic cells and has been proposed as an antineoplastic.
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen, and general lymphoid tissue. In the classical variant, giant usually multinucleate Hodgkin's and REED-STERNBERG CELLS are present; in the nodular lymphocyte predominant variant, lymphocytic and histiocytic cells are seen.
Fever in which the etiology cannot be ascertained.
Small masses of chromaffin cells found near the SYMPATHETIC GANGLIA along the ABDOMINAL AORTA, beginning cranial to the superior mesenteric artery (MESENTERIC ARTERY, SUPERIOR) or renal arteries and extending to the level of the aortic bifurcation or just beyond. They are also called the organs of Zuckerkandl and sometimes called aortic bodies (not to be confused with AORTIC BODIES in the THORAX). The para-aortic bodies are the dominant source of CATECHOLAMINES in the FETUS and normally regress after BIRTH.
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)
Unanticipated information discovered in the course of testing or medical care. Used in discussions of information that may have social or psychological consequences, such as when it is learned that a child's biological father is someone other than the putative father, or that a person tested for one disease or disorder has, or is at risk for, something else.
The hollow, muscular organ that maintains the circulation of the blood.
The statistical reproducibility of measurements (often in a clinical context), including the testing of instrumentation or techniques to obtain reproducible results. The concept includes reproducibility of physiological measurements, which may be used to develop rules to assess probability or prognosis, or response to a stimulus; reproducibility of occurrence of a condition; and reproducibility of experimental results.
Remnant of a tumor or cancer after primary, potentially curative therapy. (Dr. Daniel Masys, written communication)
The restoration of blood supply to the myocardium. (From Dorland, 28th ed)
Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)
A general term for various neoplastic diseases of the lymphoid tissue.
Neoplasms of whatever cell type or origin, occurring in the extraskeletal connective tissue framework of the body including the organs of locomotion and their various component structures, such as nerves, blood vessels, lymphatics, etc.
Studies in which individuals or populations are followed to assess the outcome of exposures, procedures, or effects of a characteristic, e.g., occurrence of disease.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A sulfur-containing essential L-amino acid that is important in many body functions.
Accumulation of a drug or chemical substance in various organs (including those not relevant to its pharmacologic or therapeutic action). This distribution depends on the blood flow or perfusion rate of the organ, the ability of the drug to penetrate organ membranes, tissue specificity, protein binding. The distribution is usually expressed as tissue to plasma ratios.
Any of a group of malignant tumors of lymphoid tissue that differ from HODGKIN DISEASE, being more heterogeneous with respect to malignant cell lineage, clinical course, prognosis, and therapy. The only common feature among these tumors is the absence of giant REED-STERNBERG CELLS, a characteristic of Hodgkin's disease.
Positive test results in subjects who do not possess the attribute for which the test is conducted. The labeling of healthy persons as diseased when screening in the detection of disease. (Last, A Dictionary of Epidemiology, 2d ed)
Tumors or cancer located in bone tissue or specific BONES.
Non-invasive methods of visualizing the CENTRAL NERVOUS SYSTEM, especially the brain, by various imaging modalities.
Combination or superimposition of two images for demonstrating differences between them (e.g., radiograph with contrast vs. one without, radionuclide images using different radionuclides, radiograph vs. radionuclide image) and in the preparation of audiovisual materials (e.g., offsetting identical images, coloring of vessels in angiograms).
A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.
Any visual display of structural or functional patterns of organs or tissues for diagnostic evaluation. It includes measuring physiologic and metabolic responses to physical and chemical stimuli, as well as ultramicroscopy.
The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. The drugs need not be in the same dosage form.
The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.
A malignant epithelial tumor with a glandular organization.
An enzyme that catalyzes the conversion of ATP and a D-hexose to ADP and a D-hexose 6-phosphate. D-Glucose, D-mannose, D-fructose, sorbitol, and D-glucosamine can act as acceptors; ITP and dATP can act as donors. The liver isoenzyme has sometimes been called glucokinase. (From Enzyme Nomenclature, 1992) EC 2.7.1.1.
Neoplasms of the thin serous membrane that envelopes the lungs and lines the thoracic cavity. Pleural neoplasms are exceedingly rare and are usually not diagnosed until they are advanced because in the early stages they produce no symptoms.
Care given during the period prior to undergoing surgery when psychological and physical preparations are made according to the special needs of the individual patient. This period spans the time between admission to the hospital to the time the surgery begins. (From Dictionary of Health Services Management, 2d ed)
Nucleosides that have two hydroxy groups removed from the sugar moiety. The majority of these compounds have broad-spectrum antiretroviral activity due to their action as antimetabolites. The nucleosides are phosphorylated intracellularly to their 5'-triphosphates and act as chain-terminating inhibitors of viral reverse transcription.
A technetium imaging agent used to reveal blood-starved cardiac tissue during a heart attack.
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)
They are oval or bean shaped bodies (1 - 30 mm in diameter) located along the lymphatic system.

Comparative efficacy of positron emission tomography with FDG and computed tomographic scanning in preoperative staging of non-small cell lung cancer. (1/3939)

OBJECTIVE: To determine the sensitivity, specificity, and accuracy of positron emission tomography with 2-fluorine-18-fluorodeoxyglucose (PET-FDG) in the preoperative staging (N and M staging) of patients with lung cancer. The authors wanted to compare the efficacy of PET scanning with currently used computed tomography (CT) scanning. MATERIALS AND METHODS: Results of whole-body PET-FDG imaging and CT scans were compared with histologic findings for the presence or absence of lymph node disease or metastatic sites. Sampling of mediastinal lymph nodes was performed using mediastinoscopy or thoracotomy. RESULTS: PET-FDG imaging was significantly more sensitive, specific, and accurate for detecting N disease than CT. PET changed N staging in 35% and M staging in 11% of patients. CT scans helped in accurate anatomic localization of 6/57 PET lymph node abnormalities. CONCLUSION: PET-FDG is a reliable method for preoperative staging of patients with lung cancer and would help to optimize management of these patients. Accurate lymph node staging of lung cancer may be ideally performed by simultaneous review of PET and CT scans.  (+info)

Enhanced myocardial glucose use in patients with a deficiency in long-chain fatty acid transport (CD36 deficiency). (2/3939)

CD36 is a multifunctional, 88 kDa glycoprotein that is expressed on platelets and monocytes/macrophages. CD36 also has high homology with the long-chain fatty acid (LFA) transporter in the myocardium. Although platelet and monocyte CD36 levels can indicate a CD36 deficiency, they cannot predict specific clinical manifestations in the myocardium of a given person. We examined the hypothesis that a deficiency in LFA transport augments myocardial glucose uptake in patients with a type I CD36 deficiency. METHODS: Seven fasting patients with a type I CD36 deficiency and 9 controls were assessed by cardiac radionuclide imaging using beta-methyl-p-iodophenyl-pentadecanoic acid (BMIPP) as a LFA tracer and by PET with 18F-fluorodeoxyglucose (FDG). RESULTS: None of the patients with a CD36 deficiency showed myocardial uptake of BMIPP. The percentage dose uptake of BMIPP in these subjects was significantly lower than that in normal controls (1.31+/-0.24 versus 2.90+/-0.2; P < 0.005). PET studies revealed that myocardial FDG accumulation was substantially increased in patients with a CD36 deficiency. Quantitative analysis showed that the percentage dose uptake of FDG in patients with a CD36 deficiency was significantly higher than that in normal controls (1.28+/-0.35 versus 0.43+/-0.22; P< 0.01). CONCLUSION: CD36 functions as a major myocardial LFA transporter and its absence may cause a compensatory upregulation of myocardial glucose uptake.  (+info)

Detection of liver metastases from pancreatic cancer using FDG PET. (3/3939)

We evaluated the potential of the glucose analog [18F]fluorodeoxyglucose (FDG) as a PET tracer for the hepatic staging in 168 patients designated for resective pancreatic surgery. METHODS: Metastatic liver disease was confirmed or excluded during surgery or with CT follow-up for at least 6 mo. Proven metastases were then retrospectively identified on preoperative CT (gold standard). Hepatic PET scans of all patients were interpreted blindly. Any focal FDG uptake was considered malignant. Both proven hepatic metastases and suspicious hepatic PET lesions were then compared, lesion by lesion, with CT. Standardized uptake values (SUV) and tumor-to-liver ratios (T/L) were determined for the most intense lesion of each patient. RESULTS: Sensitivity of FDG PET was 68% (15 of 22 patients). The lesion detection rate was 97% (28 of 29 metastases) for lesions >1 cm and 43% (16 of 37 metastases) for lesions < or = 1 cm. Specificity was 95% (138 of 146 patients). Six of eight patients with false-positive results had marked intrahepatic cholestasis (versus 3 of 15 patients with true-positive lesions), one had an infrahepatic abscess and one had a right basal pulmonary metastasis. The SUV and T/L were 4.6+/-1.4 and 2.3+/-1.1, respectively, for malignant lesions and 4.1+/-1.5 and 1.9+/-0.3, respectively, for false-positive lesions and therefore are of limited value. CONCLUSION: FDG PET provides reliable hepatic staging for lesions >1 cm. False-positive results are associated with the presence of marked intrahepatic cholestasis. For lesions < or = 1 cm, FDG PET can define malignancy in 43% of suspicious CT lesions in the absence of dilated bile ducts.  (+info)

Synthesis and evaluation of [18F]1-amino-3-fluorocyclobutane-1-carboxylic acid to image brain tumors. (4/3939)

We have developed a new tumor-avid amino acid, 1-amino-3-fluorocyclobutane-1-carboxylic acid (FACBC), labeled with 18F for nuclear medicine imaging. METHODS: [18F]FACBC was prepared with high specific activity (no carrier added [NCA]) and was evaluated for its potential in tumor localization. A comparative study was performed for [18F]FACBC and [18F]2-fluorodeoxyglucose (FDG) in which the uptake of each agent in 9L gliosarcoma (implanted intracerebrally in Fisher 344 rats) was measured. In addition, the first human PET study of [18F]FACBC was performed on a patient with residual glioblastoma multiforme. Quantitative brain images of the patient were obtained by using a Siemens 921 47-slice PET imaging system. RESULTS: In the rat brain, the initial level of radioactivity accumulation after injection of [18F]FACBC was low (0.11 percentage injected dose per gram [%ID/g]) at 5 min and increased slightly to 0.26 %ID/g at 60 min. The tumor uptake exhibited a maximum at 60 min (1.72 %ID/g), resulting in a tumor-to-brain ratio increase of 5.58 at 5 min to 6.61 at 60 min. In the patient, the uptake of [18F]FACBC in the tumor exhibited a maximum concentration of 146 nCi/mL at 35 min after injection. The uptake of radioactivity in the normal brain tissue was low, 21 nCi/mL at 15 min after injection, and gradually increased to 29 nCi/mL at 60 min after injection. The ratio of tumor to normal tissue was 6 at 20 min after injection. The [18F]FACBC PET scan showed intense uptake in the left frontal region of the brain. CONCLUSION: The amino acid FACBC can be radiofluorinated for clinical use. [18F]FACBC is a potential PET tracer for tumor imaging.  (+info)

Mechanisms related to [18F]fluorodeoxyglucose uptake of human colon cancers transplanted in nude mice. (5/3939)

[18F]Fluorodeoxyglucose ([18F]FDG), a glucose analogue, has been widely used for tumor imaging. To investigate the mechanisms related to [18F]FDG uptake by tumors, an experiment involving nude mice was performed. METHODS: Human colon cancer cell lines SNU-C2A, SNU-C4 and SNU-C5 were transplanted to nude mice. Using immunohistochemical staining and Western blot, the expression of glucose transporter (Glut) isoforms (Glut-1 through -5) in xenografted tumors was analyzed. For the analysis of messenger ribonucleic acid (mRNA) expression, reverse-transcription polymerase chain reaction and Northern blot were used and the enzyme activity of hexokinase in cancer tissues was measured by continuous spectrophotometric rate determination. RESULTS: [18F]FDG uptake in SNU-C4 and SNU-C5 cells was higher than in normal colon cells. Among these cells and xenografted tumors, SNU-C5 showed the highest level of [18F]FDG uptake, followed by SNU-C4 and SNU-C2A. An immunostaining experiment showed intense staining of Glut-1 in SNU-C5 tumors but somewhat faint staining in SNU-C4. SNU-C5 tumors also showed positive staining with Glut-3, although this was not the case with SNU-C2A and SNU-C4. Western blot analysis showed the expression of Glut-1 and Glut-3 in all tumors. Experiments involving Northern blot analysis and reverse-transcription polymerase chain reaction confirmed the overexpression of Glut-1 mRNA in all tumors, with the highest level in SNU-C5. The level of Glut-3 mRNA was also elevated in SNU-C5 tumors but not in SNU-C2A and SNU-C4. The enzyme activity of hexokinase did not vary among different tumors. CONCLUSION: Gluts, especially Glut-1, are responsible for [18F]FDG uptake in a nude mouse model of colon cancer rather than hexokinase activity. Increased numbers of glucose transporters at the plasma membrane of cancer cells is attributed to an increased level of transcripts of glucose transporter genes and may be a cause of increased [18F]FDG uptake, at least in colon cancer tumors.  (+info)

Use of positron emission tomography in evaluation of brachial plexopathy in breast cancer patients. (6/3939)

18-Fluoro-2-deoxyglucose (FDG) positron emission tomography (PET) has previously been used successfully to image primary and metastatic breast cancer. In this pilot study, 19 breast cancer patients with symptoms/signs referrable to the brachial plexus were evaluated with 18FDG-PET. In 11 cases computerized tomography (CT) scanning was also performed. Of the 19 patients referred for PET study, 14 had abnormal uptake of 18FDG in the region of the symptomatic plexus. Four patients had normal PET studies and one had increased FDG uptake in the chest wall that accounted for her axillary pain. CT scans were performed in 9 of the 14 patients who had positive brachial plexus PET studies; six of these were either normal or showed no clear evidence of recurrent disease, while three CTs demonstrated clear brachial plexus involvement. Of two of the four patients with normal PET studies, one has had complete resolution of symptoms untreated while the other was found to have cervical disc herniation on magnetic resonance imaging (MRI) scan. The remaining two patients almost certainly had radiation-induced plexopathy and had normal CT, MRI and PET study. These data suggest that 18FDG-PET scanning is a useful tool in evaluation of patients with suspected metastatic plexopathy, particularly if other imaging studies are normal. It may also be useful in distinguishing between radiation-induced and metastatic plexopathy.  (+info)

Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography. (7/3939)

We are developing quantitative assays to repeatedly and noninvasively image expression of reporter genes in living animals, using positron emission tomography (PET). We synthesized positron-emitting 8-[18F]fluoroganciclovir (FGCV) and demonstrated that this compound is a substrate for the herpes simplex virus 1 thymidine kinase enzyme (HSV1-TK). Using positron-emitting FGCV as a PET reporter probe, we imaged adenovirus-directed hepatic expression of the HSV1-tk reporter gene in living mice. There is a significant positive correlation between the percent injected dose of FGCV retained per gram of liver and the levels of hepatic HSV1-tk reporter gene expression (r2 > 0.80). Over a similar range of HSV1-tk expression in vivo, the percent injected dose retained per gram of liver was 0-23% for ganciclovir and 0-3% for FGCV. Repeated, noninvasive, and quantitative imaging of PET reporter gene expression should be a valuable tool for studies of human gene therapy, of organ/cell transplantation, and of both environmental and behavioral modulation of gene expression in transgenic mice.  (+info)

Reciprocal ST-segment depression associated with exercise-induced ST-segment elevation indicates residual viability after myocardial infarction. (8/3939)

OBJECTIVES: We evaluated the clinical significance of reciprocal ST-segment depression associated with exercise-induced ST-segment elevation for detecting residual viability within the infarcted area. BACKGROUND: Although the relation between residual viability and exercise-induced ST-segment elevation has been described, there are no reports focusing on the relation between myocardial viability and reciprocal ST-segment depression associated with exercise-induced ST-segment elevation. METHODS: We evaluated regional blood flow and glucose utilization using N-13 ammonia (NH3) and F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) in 30 patients with a previous Q-wave myocardial infarction (anterior in 15, inferior in 15). All subjects had single-vessel disease and had exercise-induced ST-segment elevations (> or =1 mm) in electrocardiographic leads. RESULTS: Reciprocal ST-segment depression (> or =1 mm) was present in 16 patients (Group A; anterior in 6, inferior in 10) but not in the remaining 14 patients (Group B). The degree of exercise-induced ST-segment elevation (1.8+/-0.2 vs. 2.0+/-0.2 mm) and the time from the onset of infarction to the study (75+/-49 vs. 74+/-52 days) did not differ between groups. There were no significant differences between groups in the severity of left ventricular dysfunction and the residual luminal narrowing in the infarct-related artery (45+/-21 vs. 48+/-25%). The presence and site of infarction were confirmed by NH3-PET in all patients. FDG-PET demonstrated residual tissue viability within infarct-related area in all patients in Group A and in 3 (21%) of 14 patients in Group B (p < 0.01). The sensitivity, specificity and accuracy of reciprocal ST-segment depression associated with exercise-induced ST-segment elevation for detecting residual viability were 84%, 100% and 90%, respectively. CONCLUSIONS: The occurrence of reciprocal ST-segment depression associated with exercise-induced ST segment elevation in patients with a previous Q-wave infarction who had single-vessel disease indicates residual tissue viability within the infarct-related area.  (+info)

BACKGROUND: Inflammation plays a key role in progression and destabilization of atherosclerotic plaque. [18F]-fluorodeoxyglucose positron emission tomography (18FDG-PET) is a promising tool for visualizing inflammation of atherosclerotic plaque. Anti-inflammatory action is one of the pleiotropic effects of statins.. OBJECTIVE: We investigated whether simvastatin attenuates plaque inflammation by using 18FDG-PET co-registered with computed tomography.. METHODS and RESULTS: Forty-three consecutive subjects, who underwent 18FDG-PET for cancer screening and had 18FDG uptakes in the thoracic aorta and/or the carotid arteries, were randomized to either statin group receiving simvastatin (n=21) or diet group receiving dietary managements (n=22). The maximum standardized uptake values (SUVs) were measured in individual plaques, and were averaged for analysis of the subject-wise results. The responses were assessed after 3-month treatments. PET revealed 117 and 123 18FDG-positive plaques in the statin ...
TY - JOUR. T1 - Diagnostic role of 18F-fluorodeoxyglucose positron emission tomography for follicular lymphoma with gastrointestinal involvement. AU - Iwamuro, Masaya. AU - Okada, Hiroyuki. AU - Takata, Katsuyoshi. AU - Shinagawa, Katsuji. AU - Fujiki, Shigeatsu. AU - Shiode, Junji. AU - Imagawa, Atsushi. AU - Araki, Masashi. AU - Morito, Toshiaki. AU - Nishimura, Mamoru. AU - Mizuno, Motowo. AU - Inaba, Tomoki. AU - Suzuki, Seiyu. AU - Kawai, Yoshinari. AU - Yoshino, Tadashi. AU - Kawahara, Yoshiro. AU - Takaki, Akinobu. AU - Yamamoto, Kazuhide. N1 - Copyright: Copyright 2021 Elsevier B.V., All rights reserved.. PY - 2012. Y1 - 2012. N2 - AIM: To investigate the capacity for 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) to evaluate patients with gastrointestinal lesions of follicular lymphoma. METHODS: This retrospective case series consisted of 41 patients with follicular lymphoma and gastrointestinal involvement who underwent 18F-FDG-PET and endoscopic evaluations at ten ...
Deep learning (DL)-based image quality improvement is a novel technique based on convolutional neural networks. The aim of this study was to compare the clinical value of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) images obtained with the DL method with those obtained using a Gaussian filter. Fifty patients with a mean age of 64.4 (range, 19-88) years who underwent 18F-FDG PET/CT between April 2019 and May 2019 were included in the study. PET images were obtained with the DL method in addition to conventional images reconstructed with three-dimensional time of flight-ordered subset expectation maximization and filtered with a Gaussian filter as a baseline for comparison. The reconstructed images were reviewed by two nuclear medicine physicians and scored from 1 (poor) to 5 (excellent) for tumor delineation, overall image quality, and image noise. For the semi-quantitative analysis, standardized uptake values in tumors and healthy tissues were compared between images obtained using
F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used in the initial evaluation and response assessment of patients with Hodgkins lymphoma (HL). Its sensitivity for nodal and extranodal sites of disease can add to the staging information obtained with CT alone,1 and PET is valuable in the response assessment at the end of front-line therapy because it can distinguish active disease from fibrosis in residual masses. In fact, the goal of front-line therapy is now a PET-negative complete remission (CR).2 Interim PET scan, performed during the initial course of therapy, may also have prognostic significance,3 and treatment adapted to interim PET results is under investigation in ongoing clinical trials. The role of PET in the response assessment and management of relapsed and refractory HL is less well established than in the front-line setting. Up to 30 % of patients with HL will fail to respond to, or will relapse after, ...
It has been well established that hepatocellular carcinomas (HCCs) accumulate [[sup 18]F]fluorodeoxy-glucose (FDG) to varying degrees; this is thought to be due to differing amounts of FDG-6-phosphatase activity. The purpose of this study was to evaluate the impact of FDG imaging on the management of patients diagnosed with hepatocellular carcinoma. We conducted a retrospective review of the clinical data of 91 consecutive patients diagnosed with HCC who underwent FDG-positron emission tomography (PET) imaging between August 1993 and March 2001. The patients were divided into two groups. In Group one 67 of 91 (74%) patients were evaluated for proven but untreated hepatic lesions using PET. In Group two the remaining 24 patients (26%) were referred for evaluation of HCC recurrence but did not have prior PET. The FDG images were acquired with two dedicated PET tomographs [Siemens ECAT 933, CTI (Knoxville, TN) and GE Advance, General Electric Medical Systems (Milwaukee, WI)] one hour after the ...
The diagnosis of prosthetic valve endocarditis (PVE) remains challenging. In PVE cases, initial echocardiography is normal or inconclusive in almost 30% of cases, leading to a decreased diagnostic accuracy for the modified Duke criteria.. Aims: The investigators sought to determine the value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) for diagnosing PVE.. Methods: In two referral French centers (Timone Hospial, Marseille and Georges Pompidou European Hospital, Paris), the investigators plan to include consecutive patients suspected of having PVE. All of the patients will be subjected to clinical, microbiological, and echocardiographic evaluation. Cardiac PET/CT will be performed at admission and the data analysis will be based on visual interpretation and quantitative measurement of FDG uptake (SUVmax). The final diagnosis will be defined according to the clinical and/or pathological modified Duke criteria determined during a 3-month follow-up ...
All subjects received 20 mg/kg/day Sapropterin (KUVAN) for four months. Subjects were examined with fluorodeoxyglucose positron emission tomography (FDG-PET) brain imaging, physical and neurological exam, blood tests for phenylalanine (Phe) and tyrosine levels, and neuropsychological testing before and 4 months after KUVAN therapy. Subjects Phe and tyrosine levels were monitored weekly during the study and subjects kept 3-day diet records to allow for calculation of Phe intake ...
18F-fluorodeoxyglucose Positron Emission Tomography (FDG-PET) Imaging has been extensively used in the evaluation of various malignancies and is rapidly
A proportion of patients with pancreatic cancer never develop metastatic disease. We evaluated a role for (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in identifying a subset of patients with locally advanced pancreatic cancer (LAPC) who never develop metastatic disease and only experience local disease and may therefore benefit from local treatment intensification.
PubMedID: 23509326 | Fasting 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography to detect metabolic changes in pulmonary arterial hypertension hearts over 1 year. | Annals of the American Thoracic Society | 2/1/2013
Distribution: In four healthy male volunteers, receiving an intravenous administration of 30 seconds in duration, the arterial blood level profile for Fludeoxyglucose F 18 decayed triexponentially. The effective half-life ranges of the three phases were 0.2-0.3 minutes, 10-13 minutes with a mean and standard deviation (STD) of 11.6 (±) 1.1 min, and 80-95 minutes with a mean and STD of 88 (±) 4 min.. Plasma protein binding of Fludeoxyglucose F 18 has not been studied.. Metabolism: Fludeoxyglucose F 18 is transported into cells and phosphorylated to [18F]- FDG-6- phosphate at a rate proportional to the rate of glucose utilization within that tissue. [F 18]-FDG-6-phosphate presumably is metabolized to 2-deoxy-2-[F 18]fluoro-6- phospho-D-mannose([F 18]FDM-6-phosphate).. Fludeoxyglucose F 18 Injection USP may contain several impurities (e.g., 2-deoxy-2-chloro-D-glucose (ClDG)). Biodistribution and metabolism of ClDG are presumed to be similar to Fludeoxyglucose F 18 and would be expected to result ...
Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography (PET) has been recommended as a complementary tool for the staging of various malignancies, including malignant lymphoma. PET...
Ahmad Mirza, MD, Ian Welch, Simon Galloway. The University Hospital of South Manchester, Manchester, United Kingdon. INTRODUCTION: The staging laparoscopy has been used in management of gastrointestinal cancers. The aim of this study was to evaluate the role of staging laparoscopy, in comparison with computed tomography (CT) and Fluorodeoxyglucose positron emission tomography (FDG-PET) imaging in staging patients with gastroesophageal junction (GOJ) and gastric cancer.. METHODS: The data were collected for patients between 1996 and 2013 for patients undergoing investigation and treatment for GOJ and gastric cancer at a single institute. The pre-operative data (staging data), intra-operative details, post-operative course and outpatient follow-up were analysed for individual cases.. RESULTS: Staging laparoscopy altered management plan in 54 (14%) of 387 patients. Patients with negative staging CT scan and negative FDG-PET, 7% (Type I, II and III GOJ) were identified with pathological ...
PURPOSE To assess the value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in patients with nasopharyngeal carcinoma as compared with PET and conventional imaging (CI) alone, and to assess the impact of PET/CT on further clinical management. METHODS AND MATERIALS Thirty-three patients with nasopharyngeal carcinoma had 45 PET/CT examinations. The study was a retrospective analysis. Changes in patient care resulting from the PET/CT studies were recorded. RESULTS Positron emission tomography/computed tomography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 92%, 90%, 90%, 90%, and 91%, respectively, as compared with 92%, 65%, 76%, 86%, and 80% for PET and 92%, 15%, 60%, 60%, and 60% for CI. Imaging with PET/CT altered further management of 19 patients (57%). Imaging with PET/CT eliminated the need for previously planned diagnostic procedures in 11 patients, induced a change in the planned therapeutic
AIM: The aim of this study was to evaluate the role of 18F fluorodeoxyglucose-positron emission tomography (FDG-PET), differentiated thyroid carcinoma (DTC) treated with therapeutic (131)I because of elevated thyroglobulin (Tg) levels during follow up. The results of FDG-PET/CT were compared with post-therapy (131)I whole body scan (131I-t-WBS) and Tg at short term follow up.. METHODS: Forty-five patients with DTC underwent a new therapeutic (131I) administration based upon Tg values ,1.5 ng/mL. All patients underwent (131I-t-WBS) 5-7 days after 131I therapy. A few days before 131I administration, a FDG-PET scan was performed in all patients. FDG-PET/CT was considered positive (PET+) when at least one abnormal focus of FDG uptake was found; likewise, 131I-t-WBS was considered positive(WBS+) when at least on abnormal focus of uptake was found. Assessment of short-term response to radioiodine was performed by measuring Tg values.. RESULTS: FDG-PET/CT was positive in 32 patients, 23 of which had ...
Although 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET) is a delicate modality for detecting a malignant lesion, increased 18F-FDG uptake is also seen in infected or inflammatory processes. nodes with intense 18F-FDG uptake (maximum SUV of 8.8) are seen in the right axilla (in a and c), which were diagnosed with tuberculous lymphadenitis. Moreover, a lymph node with intense 18F-FDG uptake (optimum SUV of 5.0) sometimes appears in the proper lower paratracheal section of the mediastinum (in a and c) Subsequently, she underwent best mastectomy with best axillary lymph node dissection. Histopathological study of the right breasts lesion demonstrated invasive ductal breasts carcinoma without lymphatic or vascular invasion. All 36 dissected lymph nodes demonstrated granulomatous lymphadenitis with caseation necrosis no involvement of malignancy. Special spots for acid-fast bacilli had been detrimental for the axillary lymph nodes; nevertheless, polymerase chain response (PCR) ...
Background/Purpose: The disease activity score based on 28 joints (DAS-28) might not be sufficient to assess remission in rheumatoid arthritis (RA). Several studies have shown that patients in remission according to DAS-28 still evidence synovitis by Ultrasound (US) and Magnetic Resonance Imaging (MRI). Those patients could eventually develop irreversible joint damage. Although 18F-Fluorodeoxyglucose Positron Emission Computer Tomography (18F-FDG PET/CT) is known to be correlated with DAS-28 in patients with active RA, its role in assessing remission has not yet been evaluated.. Methods: A cross-sectional study was performed on 63 RA patients. A total of 1764 joints was assessed. Clinical assessment (DAS-28), 18F-FDG PET/CT and US were performed the same day. Patients were classified in 3 groups according to their disease status : 22 (35%) were in remission (DAS-28 , 2.6), 31 (49%) had a low or moderate disease activity (2.6 , DAS-28 ≤ 5.1) and 10 (16%) had a severe disease activity (DAS 28 , ...
Despite the growing use of [18F]-FDG PET imaging in oncology (9, 10), limited data exist regarding its use in monitoring treatment response and predicting survival in advanced TETs (11, 19-31). With a few exceptions (25, 27, 28, 30), most studies in this area have been retrospective, involving small sample sizes and inconsistent measures of [18F]-FDG uptake. Furthermore, the majority of the studies have an overrepresentation of thymoma compared with thymic carcinoma. There is limited information on its role in monitoring treatment response and as a predictor of survival (20, 23), and we are not aware of prospective systematic studies addressing these questions.. As a retrospective analysis of prospectively collected data, this study shows that in patients with advanced or recurrent TETs: (i) effective treatment with chemotherapy or targeted therapy causes rapid reduction in [18F]-FDG uptake, (ii) early metabolic response predicts eventual RECIST response and is associated with improved PFS, and ...
Background The relationship between biomechanical properties and biological activities in aortic aneurysms was investigated with finite element simulations and F-18-fluoro-deoxy-glucose (F-18-FDG) positron emission tomography. Methods and Results The study included 53 patients (45 men) with aortic aneurysms, 47 infrarenal (abdominal aortic) and 6 thoracic (thoracic aortic), who had 1 F-18-FDG positron emission tomography/computed tomography. During a 30-month period, more clinical events occurred in patients with increased F-18-FDG uptake on their last examination than in those without (5 of 18 [28%] versus 2 of 35 [6%]; P=0.03). Wall stress and stress/strength index computed by finite element simulations and F-18-FDG uptake were evaluated in a total of 68 examinations. Twenty-five (38%) examinations demonstrated 1 aneurysm wall area of increased F-18-FDG uptake. The mean number of these areas per examination was 1.6 (18 of 11) in thoracic aortic aneurysms versus 0.25 (14 of 57) in abdominal ...
Purpose: To investigate the prognostic role of metabolic response by the use of serial sets of positron emission tomography/computed tomography (PET/CT) in patients with cervical cancer who were treated with concurrent chemoradiation therapy (CCRT). Methods and Materials: A total of 60 patients who were treated with CCRT between February 2009 and December 2010 were analyzed. Three sequential PET/CT images were acquired for each patient: pre-CCRT, during-CCRT at 4 weeks of CCRT, and 1 month post-CCRT PET/CT. Metabolic responses were assessed qualitatively. The percentage changes in the maximum values of standardized uptake value (ΔSUV{sub max}%) from the PET/CT images acquired pre-CCRT and during-CCRT were calculated. Receiver operating characteristic (ROC) curve analysis was performed to evaluate whether ΔSUV{sub max}% could predict complete response (CR) on the post-CCRT PET/CT and to identify the best cutoff value. Prognostic factors of progression-free survival (PFS) were analyzed. Results: ...
Video articles in JoVE about positron emission tomography include Human Brown Adipose Tissue Depots Automatically Segmented by Positron Emission Tomography/Computed Tomography and Registered Magnetic Resonance Images, Non-invasive Imaging and Analysis of Cerebral Ischemia in Living Rats Using Positron Emission Tomography with 18F-FDG, A Basic Positron Emission Tomography System Constructed to Locate a Radioactive Source in a Bi-dimensional Space, Quantification of Atherosclerotic Plaque Activity and Vascular Inflammation using [18-F] Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography (FDG-PET/CT), Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models, The Bioconjugation and Radiosynthesis of 89Zr-DFO-labeled Antibodies, Creating Dynamic Images of Short-lived Dopamine Fluctuations with lp-ntPET: Dopamine Movies of Cigarette Smoking, Murine Lymphocyte Labeling by 64Cu-Antibody Receptor Targeting for In Vivo Cell Trafficking by
Early noninvasive FDG-PET/CT imaging of VT inflammation predicts the magnitude of subsequent VWS and may provide a new translatable approach to identify individuals at risk for postthrombotic syndrome and to assess anti-inflammatory postthrombotic syndrome therapies, such as statins.
Background Impairment in instrumental actions of daily living (IADL) begins as individuals with amnestic mild cognitive impairment (MCI) transition to Alzheimers disease (AD) dementia. to three years and baseline FDG PET. The subjective, informant-based Functional Activities Questionnaire was used to assess IADL. General linear models and mixed effects models were used, covarying for demographics, cogniton, and behavior. Results The cross-sectional analysis revealed middle frontal and orbitofrontal hypometabolism were significantly associated with greater IADL impairment. Additionally, the interaction of diagnosis with posterior cingulate and with parahippocampal hypometabolism showed a greater decline in IADL performance as metabolism decreased for the AD dementia relative to the MCI group, and the MCI group relative to the CN group. The longitudinal analysis showed that baseline middle frontal and posterior cingulate hypometabolism were significantly associated with greater rate of increase ...
The present study, discussed a rare case of a 50‑year‑old woman who was treated for malignant melanoma and underwent 18F‑fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) examination for evaluation of disease. 18F‑FDG‑PET/CT examination was performed from the top of the head down to the knee using a Gemini TF PET/CT scanner 60 min following intravenous injection of radiotracer with mean activity of 364±75 MBq. Previous performed laboratory test and clinical examination was irrelevant. By abdominal ultrasound no abnormalities in abdominal organs beside the liver cyst were found. The 18F‑FDG PET/CT exam showed an increased glucose metabolism in the anterior pole of the spleen, which was considered as melanoma metastasis. Splenectomy was performed and histopathology examination tuberculous lesion in the spleen was revealed. Histopathology examination showed epithelioid granuloma and in correlation with the patients history allowed to establish ...
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PubMed Central Canada (PMC Canada) provides free access to a stable and permanent online digital archive of full-text, peer-reviewed health and life sciences research publications. It builds on PubMed Central (PMC), the U.S. National Institutes of Health (NIH) free digital archive of biomedical and life sciences journal literature and is a member of the broader PMC International (PMCI) network of e-repositories.
Abstract:. Gestational or pregnancy‑associated breast cancer is defined as breast cancer that is diagnosed during pregnancy, in the first post‑partum year or any time during lactation. We report a rare imaging finding of breast cancer seen on fluorodeoxyglucose‑positron emission tomography/computed tomography (FDG PET/CT) study in a 32‑year‑old lactating woman. The FDG PET/CT study demonstrated uptake in the soft tissue lesion noted in the right breast corresponding to the primary lesion and multiple nodes in the bilateral axilla, right supraclavicular and mediastinum. In addition, there was FDG tracer uptake in both the breast parenchyma related to breast feeding. This case illustrates the first case of breast cancer in a lactating woman described in FDG PET/CT.. ...
Sigma-Aldrich offers abstracts and full-text articles by [Sung Gwe Ahn, Jong Tae Park, Hak Min Lee, Hak Woo Lee, Tae Joo Jeon, Kyunghwa Han, Seung Ah Lee, Seung Myung Dong, Young Hoon Ryu, Eun Ju Son, Joon Jeong].
Authors: Sally F Barrington, N George Mikhaeel, Lale Kostakoglu, Michel Meignan, Martin Hutchings, Stefan Mueller, Lawrence H Schwartz, Emanuele Zucca, Richard I Fisher, Judith Trotman, Otto S Hoekstra, Rodney J Hicks, Michael J ODoherty, Roland Hustinx, Alberto Biggi, Bruce D Cheson
BACKGROUND: To evaluate [(18)F]-2-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET), for early evaluation of response to palliative chemotherapy and for prediction of long-term outcome, in patients with metastatic colorectal cancer (mCRC). PATIENTS AND METHODS: In a randomized trial, patients with mCRC received irinotecan-based combination chemotherapy. FDG-PET was carried out before treatment and after two cycles in 51 patients at two centers. Visual changes in tumor FDG uptake and changes measured semi-automatically, as standard uptake values (SUVs), were compared with radiological response after four and eight cycles. RESULTS: The mean baseline SUV for all tumor lesions per patient was higher in nonresponders than in responders (mean 7.4 versus 5.6, P = 0.02). There was a strong correlation between metabolic response (changes in SUV) and objective response (r = 0.57, P = 0.00001), with a sensitivity of 77% and a specificity of 76%. There was no significant correlation between ...
PURPOSE: To assess prospectively the value of fluor-18-deoxyglucose (FDG) positron emission tomography (PET), in addition to conventional diagnostic methods (CDM), as a staging modality in candidates for resection of colorectal liver metastases. PATIENTS AND METHODS: In 51 patients analyzed for resection of colorectal liver metastases, clinical management decisions were recorded after a complete work-up with CDM. Afterward, FDG-PET scans were performed and any change of clinical management according to FDG-PET results was carefully documented. Discordances between FDG-PET and CDM results were identified and related to the final diagnosis by histopathology, intraoperative findings, and follow-up. RESULTS: In 10 (20%) out of 51 patients, clinical management decisions based on CDM were changed after FDG-PET findings were known. FDG-PET detected unresectable pulmonary (n = 5) and hepatic metastases (n = 1) and ruled out extrahepatic (n = 2) and hepatic disease (n = 2). Due to FDG-PET, eight patients ...
The complexities of cancer, and cachexia induced by cancer, dictate the necessity of studying this disease in the context of its microenvironment as well as in the context of interactions between the tumor and the body, i.e., the macroenvironment. In the present study, we are applying molecular and functional imaging to understand cancer cachexia and develop clinically translatable indices for early detection of this condition. As models, we are using cachectic (MAC16) and non-cachectic (MAC13) murine colon adenocarcinoma cells. MAC16 tumors induce extensive weight loss in tumor-bearing animals, whereas MAC13 tumors, although histologically similar, do not induce weight loss. By using in vivo 1H MRSI, we detected a high level of total choline in cachectic tumors compared to non-cachectic ones but no differences in lactate levels in tumor extracts. We then performed [18F]fluorodeoxyglucose positron emission tomography studies and observed a significant increase in glucose uptake in the ...
In Parkinsons disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [18F]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinsons disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinsons patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinsons Disease Rating Scale (UPDRS III) and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P , 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with ...
Purpose. The main objective of this study was to evaluate the prognostic value of volumetric and metabolic information derivied from F-18 fluorodeoxyglucose positron emission tomography (18F-FDG PET) in combination with computed tomography (CT) prior to liver transplantation (LT) in patients with nonresectable colorectal liver metastases (CLM). Due to scarcity of liver grafts, prognostic information enabling selection of candidates who will gain the highest survival after LT is of vital importance. 18F-FDG PET/CT was a part of the preoperative study protocol. Patients without evidence of extrahepatic malignant disease on 18F-FDG PET/CT who also fulfilled all the other inclusion criteria underwent LT.. Methods. The preoperative 18F-FDG PET/CT examinations of all patients included in the SECA (secondary cancer) study were retrospectively assessed. Maximum, mean and peak standardized uptake values (SUVmax, SUVmean and SUVpeak), tumor to background (T/B) ratio, metabolic tumor volume (MTV) and total ...
Background: The aim of our study is to establish the potential role of dual-phase F-fluorodeoxyglucose positron emission tomography / computed tomography (FDG-PET/CT) in patients presenting ovarian masses with diffuse peritoneal infiltration for differentiating benign from malignant lesions. Methods: Twenty patients (13 with ovarian cancers and 7 with benign lesions) were evaluated preoperatively by dual-phase F-FDG-PET/CT performed 1 h and 2 h after injection of F-FDG. The maximum standardized uptake value (SUVmax) for both time points SUVmax1 and SUVmax2 were determined, respectively, and the retention index (RI) was calculated by subtracting the SUVmax1 from the SUVmax2 and dividing by SUVmax1. Results: The areas under the receiver operating characteristic curves (AUCs) of SUVmax1 and SUVmax2 were 0.753 (P = 0.062, 95% confidence interval [CI] = 0.512-0.915) and 0.835 (P = 0.001, 95% CI = 0.604-0.961), respectively. The AUC of the RI was 0.901 (P | 0.001, 95% CI = 0.684-0.988). Using pairwise
INTRODUCTION: The prevalence and detailed biomarkers characteristic of rapidly progressive Alzheimers disease (rpAD) remain incompletely understood.METHODS: A total of 312 mild AD patients from the Alzheimers Disease Neuroimaging Initiative database were chosen and dichotomized into rpAD and non-rpAD groups. We performed the prevalence and comprehensive biomarker evaluation.RESULTS: The prevalence of rpAD was 17.6% in mild AD. Compared with non-rpAD, there were no differences in APOE ε4/ε4, APOE ε3/ε4, and APOE ε2/ε4 genotype distribution, cerebrospinal fluid tau, phosphorylated tau (p-tau), amyloid-β, hippocampus volume, and amyloid deposition in rpAD. Yet, a lower p-tau/tau ratio was observed in rpAD (P = .04). rpAD showed region-specific hypometabolism ([18F]fluorodeoxyglucose-positron emission tomography [FDG-PET]) (P = .001). Receiver-operating characteristic analysis of FDG-PET demonstrated that left angular and left temporal cortices were the regions with higher area under the ...
A form of encephalitis associated with anti-N-methyl-d-aspartate receptor (anti-NMDA-R) antibodies has recently been described.1 Reported patients are mainly young women, presenting with severe encephalitis and additional distinctive neurological features. Around 60% have an ovarian teratoma.1 The severe course of the disease does not rule out favourable prognosis. Immunotherapy is advocated1-3 and appears to be associated with improved outcome.. We present a patient with anti-NMDA-R encephalitis and serial [18F]-fluorodeoxyglucose-positron emission tomography (FDG-PET) examinations showing markedly increased activity in the basal ganglia as compared with that in the cortex when extrapyramidal features were prominent, which normalised after improvement of this movement disorder. ...
BACKGROUND: The purpose of this study was to assess the role of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and (18)F-fluorodeoxyglucose positron emission tomography computed tomography (FDG-PET/CT) for evaluation of response to chemotherapy and bevacizumab and for prediction of progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC) with potentially resectable liver lesions. METHODS: A total of 19 mCRC patients were treated with FOLFOX/FOLFIRI and bevacizumab followed by surgery. Dynamic contrast-enhanced magnetic resonance imaging and FDG-PET/CT were performed before treatment and after cycle 5. PET results were quantified by calculating maximum standardised uptake value (SUV(max)) whereas area under the enhancement curve (AUC), initial AUC (iAUC) and the endothelial transfer constant (K(trans)) were used to quantify DCE-MRI. Pathological analysis of the resection specimen was performed, including measurement of microvessel density (MVD) and ...
Background and purpose: To analyze the recurrence pattern in relation to target volumes and 18F-fluorodeoxyglucose (FDG) uptake on positron emission tomography in head and neck squamous cell carcinoma (HNSCC) patients treated with definitive chemoradiation. Material and methods: 520 patients received radiotherapy for HNSCC from 2005 to 2009. Among 100 patients achieving complete clinical response and a later recurrence, 39 patients with 48 loco-regional failures had a recurrence CT scan before any salvage therapy. The estimated point of origin of each recurrence was transferred to the planning CT by deformable image co-registration. The recurrence position was then related to the delineated target volumes and iso-SUV-contours relative to the maximum standard uptake value (SUV). We defined the recurrence density as the total number of recurrences in a sub-volume divided by the sum of that volume for all patients. Results: 54% (95% CI 37-69%) of recurrences originated inside the FDG-positive ...
F-fluorodeoxyglucose positron emission tomography and computed tomography in anaplastic thyroid cancer. Poisson, Thomas; Deandreis, Désirée; Leboulleux, Sophie; Bidault, François; Bonniaud, Guillaume; Baillot, Sylvain; Aupérin, Anne; Ghuzlan, Abir; Travagli, Jean-Paul; Lumbroso, Jean; Baudin, Eric; Schlumberger, Martin // European Journal of Nuclear Medicine & Molecular Imaging;Dec2010, Vol. 37 Issue 12, p2277 Purpose: Our aim was to evaluate in anaplastic thyroid carcinoma (ATC) patients the value of F-FDG PET/CT compared with total body computed tomography (CT) using intravenous contrast material for initial staging, prognostic assessment, therapeutic monitoring and follow-up. Methods: Twenty... ...
RATIONALE: Imaging procedures, such as fludeoxyglucose F 18 (FDG)-PET/CT scan, done before and after steroid therapy may help doctors assess a patients
TY - JOUR. T1 - Usefulness of 18F-FDG PET/CT in an Unusual Case of Solid-Pseudopapillary Pancreatic Tumor in Childhood With Aggressive Behavior. AU - Giordano, Alessandro. AU - Rufini, Vittoria. AU - Treglia, Giorgio. AU - Caporale, Nicoletta. AU - Callea, Francesco. AU - Locatelli, Franco. PY - 2013. Y1 - 2013. N2 - We report an unusual case of a solid-pseudopapillary pancreatic tumor (SPPT) with aggressive behavior that occurred in a 16-year-old male patient. 18F fluorodeoxyglucose PET/CT showed increased radiopharmaceutical uptake in a solid mass of the body of the pancreas, in several liver lesions, and in multiple peritoneal implants, corresponding to an SPPT with liver and peritoneal metastases, respectively. Based on PET/CT findings, the patient was referred to chemotherapy. In this unusual case of pediatric SPPT with aggressive behavior, 18F fluorodeoxyglucose PET/CT has been useful in staging the disease and in treatment planning.. AB - We report an unusual case of a ...
Pyrexia of unknown origin (PUO) may be related to several pathologies that need to be identified for proper treatment. PET is found to have highest diagnostic yield in identifying various causes of PUO. The aim of this study is to highlight and justify the use of 18F FDG PET (Fluorine Fluorodeoxyglucose Positron Emission Tomography) imaging as a whole body screening tool in two unique cases of febrile illness with lymphadenopathy but with diverse etiologies based on PET-guided biopsy. The unique arrangement of PET positive nodal disease as a
Title: Staging of Breast Cancer with 18F-FDG PET and PET/CT. VOLUME: 5 ISSUE: 4. Author(s):Emiel J.T. Rutgers, Wouter V. Vogel and Renato A. Valdes Olmos. Affiliation:Cancer Institute / Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.. Abstract: Fluorine-18 fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) has been recognised as a sensitive tool for the staging of various malignancies, such as lung carcinoma, lymphoma, and esophageal cancer. Its role in staging process of breast cancer however is subject to discussion, mainly due to supposedly lower metabolic activity of the disease. In this article, we discuss the current literature on FDG PET/CT for the staging of breast cancer, including staging of the primary tumour and the axilla, and the detection of distant metastases both in primary and recurrent breast cancer. In addition, we will focus on several methodological aspects and acquisition protocols to optimize the ...
AbstractNo data exist whether statins have robust anti-inflammatory effects of atherosclerotic plaques primarily during the early treatment period or continuously throughout use. This prospective three time point18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) study of the carotid artery assessed anti-inflammatory effects of statin during the early treatment...
Purpose: The objective is to investigate psychological status and quality of life (QoL) using Hospital Anxiety and Depression Scale (HADS) and Short-Form (36) Health Survey (SF-36) questionnaires in patients with proven differentiated thyroid cancer (DTC) who are referred for radioactive iodine (RAI) ablation before, during, and after treatment. Methods: Of patients who underwent total thyroidectomy with a pathologically proven DTC (papillary and follicular types) referred for RAI treatment to our department in 2018, 150, in whom the diagnosis was newly established, were referred for the first course of RAI treatment and were consecutively enrolled in the study. The patients received an oral dose of radioiodine (3700 or 5550 MBq). For evaluation of anxiety, depression, and QoL, all patients are given two standard questionnaires, HADS, and SF-36 and are requested to answer them at four time points. First one was at 1 month before RAI, second was at the time of RAI treatment. Third and fourth ones ...
Despite the widespread use of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in the diagnosis and response assessment of patients with lymphoma, few studies have assessed its value in ocular adnexal lymphomas. The purpose of this study was to evaluate the role of FDG PET/CT in staging of non-conjunctival origin ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphomas (OAML). In addition, the diagnostic sensitivity of FDG PET/CT was compared with magnetic resonance imaging (MRI). FDG PET/CT of 123 consecutive patients with pathologically proven OAML between January 2009 and February 2016 were retrospectively reviewed. The patients with MALT lymphoma originating from conjunctiva were excluded. A total 50 patients with non-conjunctival origin OAML were assessed. Maximum standardized uptake value (SUVmax) and additional PET parameters were measured for all lesions. Sensitivity for primary tumor detection was compared with MRI. Ten patients had bilateral OAML
Abstract: Objective To evaluate the correlation of the positron emission tomography/magnetic resonance imaging (PET/MR) parameters with the pathological differentiation of head and neck squamous cell carcinoma(HNSCC) and the diagnostic efficiencies of PET/MR parameters. Methods Patients with clinical suspicion of HNSCC were included and underwent PET/MR scan. HNSCC was pathologically confirmed in all these patients. The PET/MR examination included PET and MR sequences of diffusion-weighted imaging (DWI) and T2-and T1-weighted imaging. The multiple parameters of PET/MR included the mean values of apparent diffusion coefficient(ADCmean) and the maximum and mean values of standardized uptake value (SUVmax and SUVmean) were measured and estimated. The correlations of all the parameters and distribution between the different tumor differentiation groups were analyzed. Logistic regression was utilized to build the model as the PET/MR combined parameter for predicting the differentiation by multiple ...
TY - JOUR. T1 - Relationship between lymphocytopenia and circulating tumor cells as prognostic factors for overall survival in metastatic breast cancer. AU - De Giorgi, Ugo. AU - Mego, Michal. AU - Scarpi, Emanuela. AU - Giuliano, Mario. AU - Giordano, Antonio. AU - Reuben, James M.. AU - Valero, Vicente. AU - Ueno, Naoto T.. AU - Hortobagyi, Gabriel N.. AU - Cristofanilli, Massimo. PY - 2012. Y1 - 2012. N2 - Introduction: Lymphocytopenia and circulating tumor cells (CTCs) have been reported as independent prognostic factors for overall survival (OS) in metastatic breast cancer (MBC), and both have been associated with bone metastases. Our objective was to compare the prognostic significance of lymphocytopenia, CTC count, and extensive bone metastases (, 2 lesions) assessed by fluorine-18 (18F) fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) in patients with MBC. Patients and Methods: This is a retrospective study that included patients with MBC who were starting ...
Objective: The objective of this study was to compare the accuracy of calculating the primary tumor volumes using a gradient-based method and fixed threshold methods on the standardized uptake value (SUV) maps and the net influx of FDG (Ki) maps from positron emission tomography-computed tomography (PET-CT) images.. Materials and Methods: Newly diagnosed patients with head and neck cancer were recruited, and dynamic PET-CT scan and T2-weighted magnetic resonance imaging were performed. The maps of Ki and SUV were calculated from PET-CT images. The tumor volumes were calculated using a gradient-based method and a fixed threshold method at 40% of maximal SUV or maximal Ki. Four kinds of volumes, VOLKi-Gra (from the Ki maps using the gradient-based method), VOLKi-40% (from the Ki maps using the threshold of 40% maximal Ki), VOLSUV-Gra (from the SUV maps using the gradient-based method), and VOLSUV-40% (from the SUV maps using the threshold of 40% maximal SUV), were acquired and compared with VOLMRI ...
Abstract Background. The aim of the present study was to evaluate prospectively the diagnostic value of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) and conventional CT regarding the ability to detect the primary tumor site in patients with extracervical metastases from carcinoma of unknown primary (CUP) site.Patients and Methods. From January 2006 to December 2010, 136 newly diagnosed CUP patients with extracervical metastases underwent (18)F-FDG PET/CT.A standard of reference (SR) was established by a multidisciplinary team to ensure that the same set of criteria were used for classification of patients, that is, either as CUP patients or patients with a suggested primary tumor site. The independently obtained suggestions of primary tumor sites using PET/CT and CT were correlated with the SR to reach a consensus regarding true-positive (TP), true-negative, false-negative, and false-positive results.Results. SR identified a primary tumor site in ...
TY - JOUR. T1 - Significance of 18 F-Fluorodeoxyglucose (FDG) Uptake in Response to Chemoradiotherapy for Pancreatic Cancer AU - Kurahara, Hiroshi. AU - Maemura, Kosei. AU - Mataki, Yuko. AU - Sakoda, Masahiko. AU - Iino, Satoshi. AU - Kawasaki, Yota. AU - Arigami, Takaaki. AU - Mori, Shinichiro. AU - Kijima, Yuko. AU - Ueno, Shinichi. AU - Shinchi, Hiroyuki. AU - Natsugoe, Shoji. N1 - Publisher Copyright: © 2018, Society of Surgical Oncology. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.. PY - 2019/2/15. Y1 - 2019/2/15. N2 - Background: A metabolic shift to glycolysis is reportedly involved in radioresistance. We examined whether pretreatment 18 F-fluorodeoxyglucose positron emission tomography (FDG-PET), which can detect enhanced glucose uptake, was able to predict the therapeutic response to chemoradiotherapy (CRT) in patients with pancreatic cancer (PC). Methods: Of 125 PC patients (75 unresectable and 50 borderline resectable), 37 and 26 underwent induction chemotherapy ...
PURPOSE. We aimed to differentiate tuberculous peritonitis (TBP) from peritoneal carcinomatosis (PC) using a visual positron-emission tomography/computed tomography (PET/CT) scoring system based on mesenteric fluorodeoxyglucose (FDG) uptake.. METHODS. PET/CT scans from 31 patients with TBP and 92 patients with PC were retrospectively reviewed. A visual PET/CT scoring system for mesenteric FDG uptake was used according to the following characteristics: FDG uptake intensity (low = 0, moderate = 1, high = 2), FDG uptake deposits (uniform = 0, irregular = 1, ascitic = 2), FDG uptake focality (diffuse = 0, segmental = 1, focal = 2), nodularity on the corresponding CT (nonnodular = 0, micronodular = 1, macronodular = 2) and mesenteric lymphadenopathy (absent = 0, lymphadenopathy without FDG uptake = 1, lymphadenopathy with FDG uptake = 2). The FDG uptake intensity, deposits, focality, nodularity and mesenteric lymphadenopathy scores between TBP and PC were compared using chi-square tests. The ...
The purpose of this study was to determine the incidence of incidental pituitary uptake on whole-body F-18-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) and to investigate its clinical significance. The files of 40,967 patients who underwent whole-body FDG PET/CT were retrospectively reviewed. Quantification of pituitary metabolic activity was obtained by using the maximum standardized uptake value (SUVmax). Hormone assays and pituitary MRIs were performed to assess pituitary lesions. Focally increased pituitary FDG uptake on PET/CT was found in 30 of 40,967 patients, accounting for an incidence of 0.073%. The mean SUVmax of 30 patients was 8.9 +/- 6.6 (range: 3.2-32.6). Histological diagnosis was obtained in three patients and included two growth hormone-secreting adenomas and one non-functioning adenoma. Hormone assays were performed on serum samples from 11 patients, 2 of whom were shown to have hypersecretion of pituitary hormone. MRI was performed on 19 ...
TY - JOUR. T1 - 18Fluoro-deoxy-glucose positron emission tomography in assessing tumor response to preoperative chemoradiation therapy for locally advanced rectal cancer. AU - Hur, Hyuk. AU - Kim, Nam Kyu. AU - Yun, Mijin. AU - Min, Byung Soh. AU - Lee, Kang Young. AU - Keum, Ki Chang. AU - Ahn, Jung Bai. AU - Kim, Hoguen. PY - 2011/1/1. Y1 - 2011/1/1. N2 - Background This study aims to evaluate the efficacy of 18F-FDG PET in assessing tumor response after preoperative chemoradiation therapy (CRT) for rectal cancer. Methods Maximum standardized uptake value (SUV) was measured for 37 patients who underwent 18F-FDG PET before and 4 weeks after completion of preoperative CRT. Pre-SUV, post-SUV, the difference between pre- and post-SUV (ΔSUV), and reduction rate (RR) were correlated with tumor response. Results A lower mean post-SUV and a higher mean RR were shown in good tumor response (T-downstaging(+) and tumor regression grade 1, 2). Considering pathologic complete response (pCR), the mean ...
Fluorodeoxyglucose (FDG)-positron emission tomography (PET) has proved to be an accurate non-invasive imaging test for differentiating benign from malignant solitary pulmonary nodules (SPNs).1-4 However, some types of cancers, e.g. carcinoid tumours and bronchoalveolar carcinoma, have low FDG uptake that can give false-negative results. Many benign processes such as infection, inflammation and granulomatous diseases, especially tuberculosis (TB), present as SPNs with enhanced FDG uptake leading to false-positive findings.5,6 Since TB is more prevalent in South Africa than in developed countries, it may be anticipated that the accuracy of FDG-PET in differentiating benign from malignant SPNs will be significantly worse owing to a drop in specificity.. Over time the uptake of FDG continues to increase in malignant lesions, whereas it decreases or remains stable in benign lesions.7-9 It was therefore deduced that dual time-point imaging might further improve the accuracy of FDG-PET to distinguish ...
Objective. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is an accurate non-invasive imaging test for differentiating benign from malignant solitary pulmonary nodules (SPNs). We aimed to assess its diagnostic accuracy for differentiating benign from malignant SPNs in a tuberculosis (TB)-endemic area. Methods. Thirty patients, 22 men and 8 women, mean age 60 years, underwent dual time point FDG-PET/computed tomography (CT) imaging, followed by histological examination of the SPN. Maximum standard uptake values (SUVmax) with the greatest uptake in the lesion were calculated for two time points (SUV1 and SUV2), and the percentage change over time per lesion was calculated (%DSUV). Routine histological findings served as the gold standard. Results. Histological examination showed that 14 lesions were malignant and 16 benign, 12 of which were TB. SUVmax for benign and malignant lesions were 11.02 (standard deviation (SD) 6.6) v. 10.86 (SD 8.9); however, when tuberculomas were excluded from
TY - JOUR. T1 - Primary and recurrent early stage laryngeal cancer. T2 - Preliminary results of 2-[fluorine 18]fluoro-2-deoxy-D-glucose pet imaging. AU - Lowe, Val J.. AU - Kim, Han. AU - Boyd, James H.. AU - Elsenbeis, John F.. AU - Dunphy, Frank R.. AU - Fletcher, James. PY - 1999/9. Y1 - 1999/9. N2 - PURPOSE: To evaluate the effectiveness of 2-[fluorine 18]fluoro-2-deoxy- D-glucose (FDG) positron emission tomography (PET) in the identification of early stage (T1-T2) primary and recurrent laryngeal cancer. MATERIALS AND METHODS: Twelve patients with T1 or T2 laryngeal cancer underwent imaging prospectively with PET. Seven patients had new disease, and five had recurrent disease. All patients underwent imaging prior to planned therapy and tissue biopsy. PET images were evaluated by using standardized uptake ratios and visual analysis. RESULTS: Histopathologic evidence of early stage cancer was documented in the 12 patients. One had a carcinoma in situ, nine had T1 tumors, and two had T2 tumors. ...
TY - JOUR. T1 - Diagnostic value of CT density in patients with diffusely increased FDG uptake in the thyroid gland on PET/CT images. AU - Han, You Mie. AU - Kim, Young Chul. AU - Park, Eun Kyung. AU - Choe, Jae Gol. PY - 2010/7. Y1 - 2010/7. N2 - OBJECTIVE. The purpose of this article is to determine the diagnostic significance of thyroid density as determined by CT in patients with a diffuse hypermetabolic thyroid on PET/CT images. SUBJECTS AND METHODS. One hundred twelve patients were enrolled in this study, and all underwent PET/CT and a thyroid function test between August 2007 and December 2008. The 56 study patients enrolled had visible 18F-FDG uptake in the thyroid, whereas the 56 control subjects had no visible FDG uptake. Maximum standardized uptake values (SUV max), Hounsfield units, thyroid-stimulating hormone levels, free thyroxine levels, and visual assessments of thyroid CT densities (grades 0-2) were evaluated. Analyses were performed to identify variables that differed between ...
TY - JOUR. T1 - F-18 FDG PET/CT for detection of malignant involvement of peripheral nerves. T2 - Case series and literature review. AU - Bronstein, Yulia. AU - Tummala, Sudhakar. AU - Rohren, Eric M.. PY - 2011/2/1. Y1 - 2011/2/1. N2 - Purpose: To evaluate the role of positron emission tomography plus computed tomography (PET/CT) scans in detecting malignant involvement of the peripheral nerves (PNs). Material And Methods: We retrospectively reviewed medical records of all PET/CT studies performed at The University of Texas MD Anderson Cancer Center between 2003 and 2009, and selected patients in whom F-18 fluorodeoxyglucose (FDG) PET/CT findings were suspicious for malignant involvement of the PNs. We identified 26 cases of suspected tumorous involvement of the PNs that was subsequently confirmed by either biopsy or clinical follow-up. We evaluated the value of PET/CT in diagnosing malignant involvement of the PNs. Results: Of the 26 patients, 12 had lymphoma, 10 had breast cancer, 2 had lung ...
INTRODUCTION: Osseous and soft tissue sarcomas (OSTS) represent a histologic heterogeneous group of malignant tumors. Most of the current clinical data on the role of F-18 FDG PET in sarcomas come from patients studied with dedicated PET and less frequently with hardware fusion PET/CT. Therefore, we were prompted to review our experience with F-18 FDG PET/CT in OSTS.. METHODS: This is a retrospective study (January 2003-December 2005) of 44 patients with histologic diagnoses of OSTS who had F-18 FDG PET/CT at our institution. The group included 22 men and 22 women with an age range of 2 of 84 years (average, 37 +/- 20.2 years). The administered doses of F-18 FDG range 4.1 to 19.5 mCi (average, 14.3 +/- 3 mCi). Reinterpretation of the imaging studies for accuracy and data analysis from medical records was performed.. RESULTS: The sensitivity and specificity of combined F-18 FDG PET/CT were 100% (95% confidence interval [CI] = 75.7-100) and 93.3% (95% CI = 78.7-98.1) for the primary OSTS, and 80% ...
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. diastolic:
TY - JOUR. T1 - Diagnosis of recurrent brain tumor. T2 - Value of 201TI SPECT vs 18F- fluorodeoxyglucose PET. AU - Kahn, D.. AU - Follett, K. A.. AU - Bushnell, D. L.. AU - Nathan, M. A.. AU - Piper, J. G.. AU - Madsen, M.. AU - Kirchner, P. T.. PY - 1994. Y1 - 1994. N2 - OBJECTIVE. This prospective study was designed to compare the sensitivity and specificity of a relatively simple examination, 201TI chloride single- photon emission CT (SPECT), with a more complex examination, 18F- fluorodeoxyglucose (FDG) positron emission tomography (PET), in patients thought to have recurrent brain tumor. Because both agents have been shown to be markers of viable tumor, we hypothesized that their sensitivity and specificity should be the same. SUBJECTS AND METHODS. Nineteen patients with evidence of recurrent tumor on CT or MR images were studied with both 201TI SPECT and FDG PET imaging. Two patients were examined twice, so a total of 21 studies were evaluated. The 201TI SPECT and FDG PET examinations were ...
We hypothesized that quantitative PET parameters may have predictive value beyond that of traditional clinical factors such as the International Prognostic Score (IPS) among Hodgkins disease (HD) patients. Thirty HD patients treated at presentation or relapse had staging and interim-treatment PET-CT scans. The majority of patients (53%) had stage III-IV disease and 67% had IPS ≥ 2. Interim-treatment scans were performed at a median of 55 days from the staging PET-CT. Chemotherapy regimens used: Stanford V (67%), ABVD (17%), VAMP (10%), or BEACOPP (7%). Hypermetabolic tumor regions were segmented semiautomatically and the metabolic tumor volume (MTV), mean standardized uptake value (SUVmean), maximum SUV (SUVmax) and integrated SUV (iSUV) were recorded. We analyzed whether IPS, absolute value PET parameters or the calculated ratio of interim- to pre-treatment PET parameters were associated with progression free survival (PFS) or overall survival (OS). Median follow-up of the study group was 50 months.
The current study showed that CIRT performed at our institute could treat inoperable bone and soft-tissue tumors with an acceptable recurrence rate as low as that in previous reports [8-10]. CIRT induced a significant decrease of FDG accumulation in the target tumors, and the post-Tx SUVmax in the recurrence group was significantly higher than that in the no recurrence group. These results suggested that CIRT could downregulate the tumor metabolism, and the tumors that exhibited decreased glucose transport activity following CIRT showed a reduced risk of local recurrence. Meanwhile, the tumor size was hardly changed after CIRT, and seemed to be inappropriate for evaluating the response to the treatment, which was consistent with previous reports showing that the SUV from FDG-PET/CT was superior to changes in tumor size for predicting tumor necrosis induced by neoadjuvant chemotherapy [12].. While a favorable effect of CIRT to reduce the tumor activity was shown, the present study also showed ...
In diabetic cardiomyopathy, left ventricular (LV) diastolic dysfunction is one of the earliest signs of cardiac involvement prior to the definitive development of heart failure (HF). We aimed to explore the LV diastolic function using electrocardiography (ECG)-gated \(^{18}\)F-fluorodeoxyglucose positron emission tomography (\(^{18}\)F-FDG PET) imaging beyond the assessment of cardiac glucose utilization in a diabetic rat model. ECG-gated \(^{18}\)F-FDG PET imaging was performed in a rat model of type 2 diabetes (ZDF fa/fa) and ZL control rats at age of 13 weeks (n=6, respectively). Under hyperinsulinemic-euglycemic clamp to enhance cardiac activity, \(^{18}\)F-FDG was administered and subsequently, list-mode imaging using a dedicated small animal PET system with ECG signal recording was performed. List-mode data were sorted and reconstructed into tomographic images of 16 frames per cardiac cycle. Left ventricular functional parameters (systolic: LV ejection fraction (EF), heart rate (HR) vs. ...
So she and her colleagues conducted a randomised, double blind, placebo-controlled trial to see whether atorvastatin would prevent coronary plaque progression and decrease vascular inflammation in HIV-positive people without signs or symptoms of clinical CVD and optimal or near optimal LDL cholesterol levels (, 3.36 mmol/L /130mg/dl). However, participants were required to have subclinicial, coronary atherosclerosis, with one or more plaques as assessed by coronary computed tomography angiography. Eligible participants then underwent fluorodeoxyglucose positron emission tomography (FDG-PET) scanning and those with arterial inflammation, demonstrated by aortic target-to-background ratio greater than 1.6, were included in the study.. A total of 40 qualifying participants were then randomised to one year of treatment with atorvastatin or placebo to determine the effects on coronary atherosclerotic plaque. Most (about 80%) were men, the average age was around 50 years and nearly 30% were ...
Prostate cancer is a common cancer in men and continues to be a major health problem. Imaging plays an essential role in the clinical management of patients. An important goal for prostate cancer imaging is more accurate disease characterization through the synthesis of anatomic, functional, and molecular imaging information. Developments in imaging technologies, specifically magnetic resonance imaging (MRI) and positron emission tomography (PET)/computed tomography (CT), have improved the detection rate of prostate cancer. MRI has improved lesion detection and local staging. Furthermore, MRI allows functional assessment with techniques such as diffusion-weighted MRI, MR spectroscopy, and dynamic contrast-enhanced MRI. The most common PET radiotracer, (18)F-fluorodeoxyglucose, is not very useful in prostate cancer. However, in recent years other PET tracers have improved the accuracy of PET/CT imaging of prostate cancer. Among these, choline (labeled with (18)F or (11)C), (11)C-acetate, and ...
Objective - There are few studies that denote the validity of 8F-fluorodeoxyglucose (FDG) PET to detect the inflammation of severe (,70%) carotid artery stenosis in Asian populations. This study was aimed to clarify whether 18F-FDG PET can identify inflamed and vulnerable plaque at higher risk for subsequent ischemic stroke in Japanese patients with severe carotid artery stenosis.. Methods - This prospective study included 33 patients with severe carotid artery stenosis between 2006 and 2011. Of these, 12 patients were symptomatic and other 21 were asymptomatic. There were 28 males and 5 females. Their mean age was 71.1 ± 8.2 years, ranging from 48 to 85. Their clinical data were precisely collected. All 33 patients underwent 18F-FDG PET and ultrasound sonography (US) to evaluate the plaque composition prior to carotid endarterectomy (CEA). FDG uptake was quantified by maximum standardized uptake values (SUV). Following surgery, the specimens were stained with the antibodies against CD68 and ...
in European journal of nuclear medicine and molecular imaging (2016). INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume ... [more ▼]. INTRODUCTION: With 18F-FDG PET/CT, tumor uptake intensity and heterogeneity have been associated with outcome in several cancers. This study aimed at investigating whether 18F-FDG uptake intensity, volume or heterogeneity could predict the outcome in patients with non-small cell lung cancers (NSCLC) treated by stereotactic body radiation therapy (SBRT). METHODS: Sixty-three patients with NSCLC treated by SBRT underwent a 18F-FDG PET/CT before treatment. Maximum and mean standard uptake value (SUVmax and SUVmean), metabolic tumoral volume (MTV), total lesion glycolysis (TLG), as well as 13 global, local and regional textural features were analysed. The predictive value of these parameters, along with clinical ...
FDG PET/CT in Clinical Oncology : FDG PET/CT has rapidly emerged as an invaluable combined imaging modality that provides both anatomic and functional information. This book, comprising a collection of images from oncology cases, is organized according to the role of FDG PET/CT in the evaluation and management of oncology patients, and only secondarily by organ or tumor entity. In this way, it reflects the issues that clinicians
The molecular imaging of central nervous metabolic disturbances using fluorodeoxyglucose-positron emission tomography (FDG-PET) has been one of the major additions to the armamentarium for non-invasive evaluation of neurodegenerative and neuroinflammatory diseases.1 However, FDG-PET is a rather unspecific method that cannot distinguish between the different causes of hypermetabolism in given cortical or subcortical regions (eg, relative hyperactivation or inflammation). FDG-PET has gained the highest impact in the evaluation of neurodegenerative disease where given patterns of hypometabolism correlate very well with neuropsychological and clinical features.2 Nevertheless, using statistical parametric mapping, relatively increased glucose consumption … ...
Pancreatic lymphoepithelial cyst (LEC) is a rare nonmalignant cyst consisting of a benign collection of keratinizing squamous epithelial cells with lymphoid tissue. Diagnosing LEC preoperatively is considered difficult because of its non-specific clinical features; therefore, LEC is generally treated the same as a malignant tumor. Our case was a 65-year-old man who underwent pancreatoduodenectomy 3 years previously for carcinoma arising from the ampulla of Vater. A pancreatic mass in the remnant pancreatic tail was detected through follow-up abdominal contrast-enhanced computed tomography (CT). This revealed two adjacent ring-enhanced masses that had been in tight contact with the left diaphragm and were enlarged. The tumors had high signal intensity in diffusion-weighted images of magnetic resonance imaging, and fluorodeoxyglucose-positron emission tomography (FDG-PET) showed abnormal uptake (standardized uptake value maximum: 17.4). Therefore, we conducted a partial resection of the remnant pancreas
Tyrosine-kinase inhibitor (TKI) targeting angiogenesis improves the prognosis of patients with metastatic renal cell carcinoma (RCC), but its effect is temporary. In order to understand the mechanism by which RCC acquires resistance to TKI, we investigated the change of glucose accumulation in RCC by FDG PET/CT when they demonstrated progression disease (PD) against TKI. We monitored the FDG accumulation in RCC of 38 patients treated with TKI by 162 PET/CT sequentially until they were judged to demonstrate PD. Standardized uptake value (SUV), a simplified index of tissue FDG accumulation rate, was measured, and the sequential changes of max SUVmax (the highest SUV in an individual patient) was analyzed. Additionally, the expression of glucose transporter 1 (GLUT-1) and associated proteins in 786-O cells cultured under hypoxia were analyzed. The 10 patients with RCC which FDG accumulation was accelerated after beginning of TKI treatment demonstrated PD soon. The other 28 patients with RCC which FDG
The treatment of patients with glioma depended on the nature of the lesion and on histological grade of the tumor. Positron emission tomography (PET) using 13N-ammonia (NH3), 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) have been used to assess brain tumors. Our aim was to compare their diagnostic accuracies in patients with suspected cerebral glioma. Ninety patients with suspicion of glioma based on previous CT/MRI, who underwent NH3 PET, MET PET and FDG PET, were prospectively enrolled in the study. The reference standard was established by histology or clinical and radiological follow-up. Images were interpreted by visual evaluation and semi-quantitative analysis using the lesion-to-normal white matter uptake ratio (L/WM ratio). Finally, 30 high-grade gliomas (HGG), 27 low-grade gliomas (LGG), 10 non-glioma tumors and 23 non-neoplastic lesions (NNL) were diagnosed. On visual evaluation, sensitivity and specificity for differentiating tumors from NNL were 62.7% (42/67) and 95.7% (22/23) for
This was a single-institution retrospective review of an Institutional Review Board-approved prospective breast cancer database. A total of 335 consecutive patients with non-metastatic breast cancer who underwent NAC followed by BCS and RT from 2002 to 2009 were identified. Before initiation of NAC, all patients had been clinically staged according to the sixth edition of the American Joint Committee on Cancer (AJCC) guidelines. Clinical stages were evaluated by physical examination, ultrasonography, fluorodeoxyglucose-positron emission tomography (PET)/computed tomography (CT), and chest CT. Clinicopathological data were recorded, including age, menopause status, cT stage, cN stage, pathological tumor size, number of lymph nodes (LNs) identified pathologically, histological type, histological grade, ER, progesterone receptor (PR), HER2, and Ki-67 status. NAC consisted of anthracycline-based (doxorubicin 60 mg/m2 and cyclophosphamide 600 mg/m2 every 3 weeks for four cycles, n=150), taxane-based ...
Purpose. To evaluate the prognostic value of metabolic parameters and bone marrow uptake (BMU) patterns on pretherapeutic 18-F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in pediatric patients with neuroblastoma (NB).. Patients and methods. Forty-seven pediatric patients with newly diagnosed neuroblastoma who underwent 18F-FDG PET/CT were retrospectively reviewed. Clinicopathological factors and metabolic parameters including maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), total lesion glycolysis (TLG) and bone marrow uptake patterns on PET/CT were compared to predict recurrence-free survival (RFS) and overall survival (OS) by univariate and multivariate analysis.. Results. During the follow-up period, 27 (57.4%) patients experienced recurrence. MTV (P = 0.001), TLG (P = 0.004) and BMU patterns (P = 0.025) remained significant predictive factors for tumor recurrence, along with tumor size, histology, stage, lactate ...
In specialized dizziness levitra centers, endocrine oncology is a positive lr of only. Urology bosch, validity of the muscles of the. Prevention standard and complete picture of the area with an absorbable transection of rectum. Hydrated, prostate cancer: Are we over. This increase was supported by clinical symptoms will prompt assessment. Surgical orchidolysis and orchidopexy in terms of simultaneously admin - istration of corticosteroids in empirical regimens for free - living amebae are protists that are unexplained and idiosyncratic must be suitable if there is as important as the ideal level is a ct = fluorodeoxyglucose positron emission tomography studies in families. Reconstruction options uretero ureterostomy transuretero ureterostomy uretero calycostomy should be used unless hospital surveys indicate at least at the bedside. Forciea m in locally advanced pca stage t high grade tumours identified by immunoassays for toxin production and spermatogenesis has been given or not, uy j. In ...
A 69-year-old woman presented with severe subacute painful meningoradiculoneuritis. Neurophysiology showed a patchy, proximal axonal process with widespread denervation. Cerebrospinal fluid (CSF) was lymphocytic (normal T-cell predominant) with negative cytology. MRI revealed multiple sites of enhancement, but fluorodeoxyglucose positron emission tomography was negative. Bone marrow aspirate and trephine (BMAT) showed no evidence of a lymphoproliferative condition. Right brachial plexus biopsy demonstrated mixed T-cell/B-cell endoneurial inflammation not fulfilling criteria for vasculitis. She was stabilised with high-dose steroids and cyclophosphamide, followed by mycophenolate for inflammatory myeloradiculoneuritis. However, symptoms recurred when prednisolone was weaned. Although T-cell receptor gene analysis from the initial CSF demonstrated clonal rearrangements, it was only when the same clones were identified on two repeat BMATs and CSF that T-cell neurolymphomatosis, an exceedingly rare ...
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The aim of this study was to assess the value of 18F-FDG PET/CT for quantitative assessment of hepatic metabolism in patients with different stages of liver fibrosis/cirrhosis. 18F-FDG PET/CT scans of 37 patients either with or without liver fibrosis/cirrhosis, classified according to the METAVIR score (F0-F4) obtained from histopathological analysis of liver specimen, were analyzed retrospectively and classified as follows: no liver fibrosis (F0, n = 6), mild liver fibrosis (F1, n = 11), advanced liver fibrosis (F2, n = 6), severe liver fibrosis (F3, n = 5), and liver cirrhosis (F4, n = 11). The liver-to-blood ratio (LBR, scan time corrected for a reference time of 75 min) was compared between patient groups. Patients with liver fibrosis or cirrhosis (≥ F1; LBR 1.53 ± 0.35) showed a significant higher LBR than patients with normal liver parenchyma (F0, 1.08 ± 0.23; P = 0.004). In direct comparison, LBR increased up to the advanced stage of liver fibrosis (F2; 2.00 ± 0.40) and decreased until liver
As a nuclear approach, Positron Emission Tomography (PET) is a functional imaging technique which is based on the detection of gamma ray pairs emitted by a positron-emitting radionuclide. There are certain limitations to this technique such as normal tissue uptake. Therefore, it has been recommended that patients prepare before scanning. Fasting for a short while before PET imaging is an example of such preparation. In this paper, we attempted to collect the studies evaluating the effects of fasting in the three sections of cardiac, brain and abdominal PET imaging. Conclusively, we found that the effects of fasting on PET imaging can be different depending on the type of PET scanning, radiotracer, patients diseases, fasting duration and in case of any additional dietary plans. It is proposed that further study be conducted on this subject in order to determine such effects in more detail.
PET/CT is generally not useful in CLL/SLL but can assist in directing nodal biopsy if Richters transformation is suspected. a. Initial staging: PET/CT scan considered useful in selected cases. b. Restaging after completion of treatment: imaging should be performed whenever there are clinical indications. If PET/CT is used in follow-up, progressive disease should be histologically documented (e.g., biopsy) to rule out transformation c. Non-gastric MALT lymphoma, marginal zone lymphoma (nodal, splenic), a. Initial staging: PET/CT scan considered useful in selected cases. a. Initial staging: PET/CT scan considered useful under certain a. Initial staging: PET/CT scan considered essential. b. Restaging after completion of treatment: repeat all positive studies. Biopsy of PET-positive sites is recommended before changing course of treatment. The optimum timing of PET/CT is unknown; however, waiting a minimum of 8 weeks to repeat PET/CT is suggested. False positives may occur due to ...
A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver. ...
A 78-year-old Japanese man was referred to our hospital after experiencing black feces. No abnormal finding was detected in the endoscopic examination of his stomach and large intestines. Computed tomography (CT) of the abdomen revealed a tumor lesion in the right lobe of the liver. A needle biopsy of the tumor under ultrasound guidance was performed. A pathological examination of the biopsy specimen showed a diffuse proliferation of lymphoma cells, which was compatible with diffuse large B-cell lymphoma (DLBCL). F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)-CT demonstrated increased FDG uptake only in the liver tumor. We made the diagnosis of primary DLBCL of the liver. After six cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisolone (R-CHOP), the patient achieved complete remission and has maintained remission for 2 years since the diagnosis. The R-CHOP regimen might be effective therapy for primary DLBCL of the liver. ...
AIM: To evaluate integrated 2-[F-18]-fluoro-2-deoxy-D-glucose (F-18-FDG) positron-emission tomography (PET)/magnetic resonance imaging (MRI), in comparison with the standard technique, integrated F-18-FDG-PET/computed tomography (CT), in preoperative staging of oesophageal or gastroesophageal junctional cancer.. MATERIALS AND METHODS: In the preoperative staging of 16 patients with oesophageal or gastroesophageal junctional cancer, F-18-FDG-PET/MRI was performed immediately following the clinically indicated F-18-FDG-PET/CT. MRI-sequences included T1-weighted fat-water separation (Dixons technique), T2-weighted, diffusion-weighted imaging (DWI), and gadolinium contrast-enhanced T1-weighted three-dimensional (3D) imaging. PET was performed with F-18-FDG. Two separate teams of radiologists conducted structured blinded readings of F-18-FDG-PET/MRI or F-18-FDG-PET/CT, which were then compared regarding tumour measurements and characteristics as well as assessment of inter-rater agreement (Cohens ...
Peter J. Walter, Peter Herscovitch, Kong Y. Chen, and Aaron M. Cypess. b3-adrenergic receptor (AR) agonists are approved to treat only overactive bladder. However, rodent studies suggest that these drugs could have other beneficial effects on human metabolism. We performed tissue receptor profiling and showed that the human b3-AR mRNA is also highly expressed in gallbladder and brown adipose tissue (BAT). We next studied the clinical implications of this distribution in 12 healthy men given onetime randomized doses of placebo, the approved dose of 50 mg, and 200 mg of the b3-AR agonist mirabegron. There was a more-than-dose proportional increase in BAT metabolic activity as measured by [18F]-2-fluoro- D-2-deoxy-D-glucose positron emission tomography/ computed tomography (medians 0.0 vs. 18.2 vs. 305.6 mL $ mean standardized uptake value [SUVmean] $ g/mL). Only the 200-mg dose elevated both nonesterified fatty acids (68%) and resting energy expenditure (5.8%). Previously undescribed increases in ...
Solid tumors are hypoxic with altered metabolism, resulting in secretion of acids into the extracellular matrix and lower relative pH, a feature associated with local invasion and metastasis. Therapeutic and diagnostic agents responsive to this microenvironment may improve tumor-specific delivery. Therefore, we pursued a general strategy whereby caged small-molecule drugs or imaging agents liberate their parent compounds in regions of low interstitial pH. In this manuscript, we present a new acid-labile prodrug method based on the glycosylamine linkage, and its application to a class of positron emission tomography (PET) imaging tracers, termed [(18)F]FDG amines. [(18)F]FDG amines operate via a proposed two-step mechanism, in which an acid-labile precursor decomposes to form the common radiotracer 2-deoxy-2-[(18)F]fluoro-d-glucose, which is subsequently accumulated by glucose avid cells. The rate of decomposition of [(18)F]FDG amines is tunable in a systematic fashion, tracking the pKa of the ...
|i|Objectives.|/i| Glucose metabolism outside of oxidative phosphorylation, or aerobic glycolysis (AG), is a hallmark of active cancer cells that is not directly measured with standard |sup|18|/sup|F-fluorodeoxyglucose (FDG) positron emission tomography (PET). In this study, we characterized tumor regions with elevated AG defined based on PET measurements of glucose and oxygen metabolism.|i| Methods.|/i| Fourteen individuals with high-grade brain tumors underwent structural MR scans and PET measurements of cerebral blood flow (CBF), oxygen (CMRO|sub|2|/sub|) and glucose (CMRGlu) metabolism, and AG, using |sup|15|/sup|O-labeled CO, O|sub|2|/sub| and H|sub|2|/sub|O, and FDG, and were compared to a normative cohort of 20 age-matched individuals.|i| Results.|/i| Elevated AG was observed in most high-grade brain tumors and it was associated with decreased CMRO|sub|2|/sub| and CBF, but not with significant changes in CMRGlu. Elevated AG was a dramatic and early sign of tumor growth associated with decreased
TY - JOUR. T1 - 18 F-FDG PET/CT findings and circulating tumor cell counts in the monitoring of systemic therapies for bone metastases from breast cancer AU - De Giorgi, Ugo. AU - Mego, Michal. AU - Rohren, Eric M.. AU - Liu, Ping. AU - Handy, Beverly C.. AU - Reuben, James M.. AU - Macapinlac, Homer A.. AU - Hortobagyi, Gabriel N.. AU - Cristofanilli, Massimo. AU - Ueno, Naoto T.. PY - 2010/8/1. Y1 - 2010/8/1. N2 - Our objective was to compare the predictive significance of 18 F-FDG PET/CT findings and circulating tumor cell (CTC) count in patients with bone metastases from breast cancer treated with standard systemic therapy. Methods: Breast cancer patients with progressive bone-only metastatic disease without visceral metastases starting a new line of systemic therapy underwent 18 F-FDG PET/CT and had CTC counts determined before and during treatment. Disease status was reassessed by CTC count (≥5 vs. ,5 CTC/7.5 mL of blood) and 18 F-FDG PET/CT approximately 2-4 mo after initiation of the ...
F18-FDG (Fluorodeoxyglucose) Tumor imaging. Myocardial imaging IV In-vivo Imaging F18-Sodium Fluoride Bone imaging IV In-vivo ... F18-Fluorocholine Prostate tumor imaging IV In-vivo Imaging F18-Desmethoxyfallypride Dopamine receptor imaging IV In-vivo ...
Positron Emission Tomography (PET-CT) using F-18 fluorodeoxyglucose (FDG) show reduced metabolism at the site of seizure onset ...
The molecule most commonly used for this purpose is F-18 labeled fluorodeoxyglucose (FDG), a sugar, for which the waiting ... Together with NaF-F18, PET for bone imaging has been in use for 60 years for measuring regional bone metabolism and blood flow ... 18F-FDG is the most commonly used tracer for imaging muscles, and NaF-F18 is the most widely used tracer for imaging bones. PET ... For example, 18F-FDG is commonly used to detect cancer, NaF-F18 is widely used for detecting bone formation, and oxygen-15 is ...
... creating F18-fluorodeoxyglucose, which can be used as a marker of metabolic utilization. Images of activity distribution ...
PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG), called FDG-PET, is widely used in clinical oncology. ... The molecule most commonly used for this purpose is F-18 labeled fluorodeoxyglucose (FDG), a sugar, for which the waiting ... At present, however, by far the most commonly used radiotracer in clinical PET scanning is fluorodeoxyglucose (also called FDG ... PET has been widely used to image bacterial infections clinically by using fluorodeoxyglucose (FDG) to identify the infection- ...
... fluorodeoxyglucose f18 MeSH D09.400.410.209 - galactolipids MeSH D09.400.410.420 - glycosphingolipids MeSH D09.400.410.420.025 ...
"Fludeoxyglucose F 18- fludeoxyglucose f-18 injection". DailyMed. 8 May 2018. Retrieved 29 January 2020. "Fluorodeoxyglucose (F- ... Fluorodeoxyglucose (18F) (INN), or fluorodeoxyglucose F 18 (USAN and USP), also commonly called fluorodeoxyglucose and ... July 1980). "A fluorinated glucose analog, 2-fluoro-2-deoxy-D-glucose (F-18): nontoxic tracer for rapid tumor detection". ...
Its use is particularly common in the analysis of [18F]fluorodeoxyglucose ([18F]FDG) images of cancer patients. It can also be ... the SUV concept had only begun to be tested for other radiotracers such as fluorothymidine F-18 ([18F]FLT) and conclusions on ... Functional imaging Medical imaging Positron emission tomography Fluorodeoxyglucose Multi-compartment model Patlak plot ...
PET scanning with the tracer fluorine-18 (F-18) fluorodeoxyglucose (FDG), called FDG-PET, is widely used in clinical oncology. ... The molecule most commonly used for this purpose is F-18 labeled fluorodeoxyglucose (FDG), a sugar, for which the waiting ... Some radioactive tracers used for Alzheimer's are florbetapir F18, flutemetamol F18, and florbetabenF18, which are all used to ... At present,[when?] by far the most commonly used radiotracer in clinical PET scanning is fluorodeoxyglucose (also called FDG or ...
Basu S, Nair N, Banavali S (2007). "Uptake characteristics of fluorodeoxyglucose (FDG) in deep fibromatosis and abdominal ... F-18]fluoro-D-glucose-positron emission tomography: a novel application with significant implications for combined structure- ... fluorodeoxyglucose positron emission tomography in this setting". J Clin Oncol. 25 (10): 1297, author reply 1297-9. doi:10.1200 ... progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron ...
Martin Reivich-were the first scientists to conceive the idea of labeling deoxyglucose with positron-emitting fluroide (F-18), ... Fluorodeoxyglucose (FDG). Alavi holds the position of Professor of Radiology and Neurology, as well as Director of Research ...
Some radioactive tracers used for Alzheimer's are florbetapir 18F, flutemetamol F18, PiB and florbetaben 18F, which are all ... such as fluorodeoxyglucose (18F). The greatest benefit of PET scanning is that different compounds can show flow and oxygen, ...
... (131I, I-131) is an important radioisotope of iodine discovered by Glenn Seaborg and John Livingood in 1938 at the University of California, Berkeley.[1] It has a radioactive decay half-life of about eight days. It is associated with nuclear energy, medical diagnostic and treatment procedures, and natural gas production. It also plays a major role as a radioactive isotope present in nuclear fission products, and was a significant contributor to the health hazards from open-air atomic bomb testing in the 1950s, and from the Chernobyl disaster, as well as being a large fraction of the contamination hazard in the first weeks in the Fukushima nuclear crisis. This is because 131I is a major fission product of uranium and plutonium, comprising nearly 3% of the total products of fission (by weight). See fission product yield for a comparison with other radioactive fission products. 131I is also a major fission product of uranium-233, produced from thorium. Due to its mode of beta decay, ...
Chisté, V.; Bé, M. M. (2011). "F-18" (PDF). In Bé, M. M.; Coursol, N.; Duchemin, B.; Lagoutine, F.; et al. (eds.). Table de ... The most common tracer is fluorodeoxyglucose which, after intravenous injection, is taken up by glucose-requiring tissues such ...
... creating F18-fluorodeoxyglucose, which can be used as a marker of metabolic utilization. Images of activity distribution ...
"Fluorodeoxyglucose F18" by people in Harvard Catalyst Profiles by year, and whether "Fluorodeoxyglucose F18" was a major or ... "Fluorodeoxyglucose F18" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Below are the most recent publications written about "Fluorodeoxyglucose F18" by people in Profiles. ... Below are MeSH descriptors whose meaning is more general than "Fluorodeoxyglucose F18". ...
Fluorodeoxyglucose F18/pharmacokinetics*. *Glucose/metabolism. *Glucose Transporter Type 1. *Humans. *Ki-67 Antigen/metabolism* ... Expression of GLUT-1 glucose transfer, cellular proliferation activity and grade of tumor correlate with [F-18]- ... fluorodeoxyglucose uptake by positron emission tomography in epithelial tumors of the ovary.. Kurokawa T1, Yoshida Y, Kawahara ...
Home » Topics » Multiple Myeloma » Research » C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET ... More From BioPortfolio on "C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT". *Related ... C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT. 2014-08-27 04:00:36 , BioPortfolio ... F18-fluorodeoxyglucose(FDG).. Study Design. Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group ...
C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT (ACTMM). The safety and scientific ... C11-Acetate PET/CT in Multiple Myeloma: Added Value to F18-Fluorodeoxyglucose PET/CT for Staging and Response Assessment. ... aimed to prospectively assess the clinical utility of ACT PET/CT in MM as compared to the commonly used F18-fluorodeoxyglucose( ...
Defining PET / CT Protocols With Optimized F18-FDG (Fluorodeoxyglucose) Dose, Focusing on Reduced Radiation Dose and Improved ...
oa Pre- and Posttreatment Findings of F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Case of ... Pre- and Posttreatment Findings of F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Case of Acute ... A case of acute Q fever hepatitis diagnosed by F-18 FDG PET/CT. Nucl Med Mol Imaging 46: 125-128. ...
F-18) Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Pathologic Grade and Other Prognostic Variables in Bone ... F-18) Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Pathologic Grade and Other Prognostic Variables in Bone ... F-18) Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Pathologic Grade and Other Prognostic Variables in Bone ... F-18) Fluorodeoxyglucose Positron Emission Tomography as a Predictor of Pathologic Grade and Other Prognostic Variables in Bone ...
F-18]Fluorodeoxyglucose - positron emission tomography/computed tomography improves staging in patients with high-risk muscle- ... The aim of this study was to evaluate the clinical use of [F-18]-fluorodeoxyglucose-positron emission tomography/computed ... The aim of this study was to evaluate the clinical use of [F-18]-fluorodeoxyglucose-positron emission tomography/computed ... The aim of this study was to evaluate the clinical use of [F-18]-fluorodeoxyglucose-positron emission tomography/computed ...
F-18 fluorodeoxyglucose positron emission tomography for differential diagnosis of pancreatic tumors. *Masato Yoshioka1Email ... Sperti C, Pasquali C, Decet G, Chierichetti F, Liessi G, Padrazzoli S (2005) F-18-fluorodeoxyglucose positron emission ... F-18 fluorodeoxyglucose PET in vivo evaluation of pancreatic glucose metabolism for detection of pancreatic cancer. Radiology ... The utility of F-18 fluorodeoxyglucose whole body PET imaging for determining malignancy in cystic lesions of the pancreas. J ...
Value of positron emission tomography with [F-18]fluorodeoxyglucose in patients with colorectal liver metastases: a prospective ... article{Ruers2002ValueOP, title={Value of positron emission tomography with [F-18]fluorodeoxyglucose in patients with ... Diagnostic and prognostic value of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography for ...
IMPACT OF F-18-FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY BEFORE AND AFTER DEFINITIVE RADIATION THERAPY IN PATIENTS WITH ... 317585-impact-of-f-18-fluorodeoxyglucose-positron-emission-tomography-before-and-after-definitive-radiation-therapy-in-patients ...
... lymphoma of the breast and squamous cell cancer of the cervix that was detected and followed with F-18 fluorodeoxyglucose (FDG ... F-18 fluorodeoxyglucose positron emission tomography and/or computed tomography findings of an unusual breast lymphoma case and ... Kidd EA, Siegel BA, Dehdashti F, Grigsby PW: The standardized uptake value for F-18 fluorodeoxyglucose is a sensitive ... Our patient was then referred for staging with F-18 FDG PET/CT that was acquired from base of skull to upper thigh with the CT ...
1357.1 - F-18 Fluorodeoxyglucose (FDG) positron emission tomography (PET) for the evaluation of breast cancer Page last updated ...
Lowe, VJ, Hebert, ME, Anscher, MS & Coleman, RE 1998, Serial evaluation of increased chest wall F-18 fluorodeoxyglucose (FDG) ... Fingerprint Dive into the research topics of Serial evaluation of increased chest wall F-18 fluorodeoxyglucose (FDG) uptake ... keywords = "F-18 fluorodeoxyglucose (FDG), Lung neoplasms, Positron emission tomography (PET), Therapeutic radiology, Treatment ... Serial evaluation of increased chest wall F-18 fluorodeoxyglucose (FDG) uptake following radiation therapy in patients with ...
Fallacy of Quantifying Lymphoma Activity by Scaling to the Liver in [F-18] Fluorodeoxyglucose Positron Emission Tomography ( ... 1024563-fallacy-of-quantifying-lymphoma-activity-by-scaling-to-the-liver-in-[f-18]-fluorodeoxyglucose-positron-emission- ...
F-18-Fluorodeoxyglucose-Positron Emission Tomography. The day after progenitor cell therapy, F-18-fluorodeoxyglucose-positron ... Quantitative F-18-fluorodeoxyglucose-positron emission tomography analysis revealed a significant (P,0.01) increase in ... The use of low-dose intravenous insulin in clinical myocardial F-18 FDG PET scanning. Clin Nucl Med. 1996; 21: 15-18. ... Optimal metabolic conditions during fluorine-18 fluorodeoxyglucose imaging; a comparative study using different protocols. Eur ...
Myocardial F-18 Fluorodeoxyglucose Imaging by SPECT. BAX, JEROEN J.; VISSER, FRANZ C.; van LINGEN, ARTHUR; More ... RADIONUCLIDE IMAGING OF CANINE MAMMARY TUMORS WITH THALLIUM-201, TC-99M SESTAMIBI AND F-18 FLUORODEOXYGLUCOSE. Carlson, K A; ...
Hwang, J. H., Kim, S., & Lee, J. K. (2009). F18-fluorodeoxyglucose-positron emission tomography for diagnosis of pelvic ... Hwang, JH, Kim, S & Lee, JK 2009, F18-fluorodeoxyglucose-positron emission tomography for diagnosis of pelvic tuberculosis ... F18-fluorodeoxyglucose-positron emission tomography for diagnosis of pelvic tuberculosis mimicking peritoneal carcinomatosis. ... F18-fluorodeoxyglucose-positron emission tomography for diagnosis of pelvic tuberculosis mimicking peritoneal carcinomatosis. ...
F-18 Fluorodeoxyglucose PET/CT Findings in Active Hiccups. Yeatman, C Fitzhugh II; Minoshima, Satoshi ... Dual-Time F-18 FDG-PET/CT Imaging for Diagnosis of Occult Non-Hodgkin Lymphoma in a Patient With Esophageal Cancer. ... F-18 FDG PET-CT Imaging in Recurrent Cerebral Gliosarcoma. Ho, Linh Thuy; Wassef, Heidi; Henderson, Robert; More ... F-18 FDG-Avid Intrathyroidal Parathyroid Adenoma Mimicking Follicular Neoplasm. Kim, Mee Kyoung; Kim, Guil Sun; Kim, Su Yoen; ...
Fluorodeoxyglucose F18. *Humans. *Kluver-Bucy Syndrome/complications. *Kluver-Bucy Syndrome/pathology*. *Kluver-Bucy Syndrome/ ...
Gallium-67 Scintigraphy and F-18 Fluorodeoxyglucose Position Emission Tomography in Posttransplant Lymphoproliferative Disorder ...
... and may be quantified using 18-fluorodeoxyglucose positron emissi... ... Fluorodeoxyglucose F18. *Neutrophil. *α1-antitrypsin deficiency. Get free article suggestions today. Mendeley saves you time ... and may be quantified using 18-fluorodeoxyglucose positron emission tomography-computed tomography ((18)FDG PET-CT) as a ...
Fluorodeoxyglucose F18. Gastrointestinal Agents. Antineoplastic Agents, Hormonal. Antineoplastic Agents. Radiopharmaceuticals. ...
Fluorodeoxyglucose F18 Grant support * 115131-1/Canadian Institutes of Health Research/Canada ... fluorodeoxyglucose ([18F]FDG) PET at baseline and at 24 months. A voxel-based interaction model was built to test the ...
Fluorodeoxyglucose F18. Radiopharmaceuticals. Molecular Mechanisms of Pharmacological Action. To Top. *For Patients and ...
... positron emission tomography with 18F-fluorodeoxyglucose, and biopsy findings (when available) were used to categorize each ... Fluorodeoxyglucose F18 * Follow-Up Studies * Glioma / metabolism * Glioma / pathology* * Glioma / therapy * Humans ...
The Role of F18-fluorodeoxyglucose Positron Emission Tomography in the Management of Relapsed or Refractory Hodgkins Lymphoma ... F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used ... Home , News , The Role of F18-fluorodeoxyglucose Positron Emission Tomography in the Management of Relapsed or Refractory ... Palmer J, Goggins T, Broadwater G, et al., Early post transplant (F-18) 2-fluoro-2-deoxyglucose positron emission tomography ...
指紋 深入研究「F-18 fluorodeoxyglucose positron emission tomography in an anorectal fistula with actinomycosis」主題。共同形成了獨特的指紋。 * ... F-18 fluorodeoxyglucose positron emission tomography in an anorectal fistula with actinomycosis. Chung-Huei Hsu, Chi-Ming Lee, ... Hsu, C-H., Lee, C-M., Chia, C. F., & Lin, Y-H. (2004). F-18 fluorodeoxyglucose positron emission tomography in an anorectal ... F-18 fluorodeoxyglucose positron emission tomography in an anorectal fistula with actinomycosis. / Hsu, Chung-Huei; Lee, Chi
Value of positron emission tomography with [F-18]fluorodeoxyglucose in patients with colorectal liver metastases: a prospective ...
  • Abdominal immune-related adverse events: detection on ultrasonography, CT, MRI and 18F-Fluorodeoxyglucose positron emission tomography. (harvard.edu)
  • Prognostic Value of Preoperative Imaging: Comparing 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography to Computed Tomography Alone for Preoperative Planning in High-risk Histology Endometrial Carcinoma. (harvard.edu)
  • Positron emission tomography combined with computed tomography using carbon-11 acetate (ACT PET/CT) may help detect lesions before treatment and evaluate response following therapy in patients with from multiple myeloma (MM). This study aimed to prospectively assess the clinical utility of ACT PET/CT in MM as compared to the commonly used F18-fluorodeoxyglucose(FDG). (clinicaltrials.gov)
  • The aim of this study was to evaluate the clinical use of [F-18]-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) in addition to conventional preoperative radiological investigations in a defined group of patients with high-risk muscle-invasive bladder cancer. (lu.se)
  • Value of positron emission tomography with [F-18]fluorodeoxyglucose in patients with colorectal liver metastases: a prospective study. (semanticscholar.org)
  • We report a case of a 46-year-old woman of unknown ethnic origin diagnosed with concurrent diffuse large B-cell lymphoma of the breast and squamous cell cancer of the cervix that was detected and followed with F-18 fluorodeoxyglucose (FDG) positron emission tomography and/or computed tomography (PET/CT). (biomedcentral.com)
  • Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for s. (nih.gov)
  • Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG-PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta-analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project. (nih.gov)
  • Hwang, JH , Kim, S & Lee, JK 2009, ' F18-fluorodeoxyglucose-positron emission tomography for diagnosis of pelvic tuberculosis mimicking peritoneal carcinomatosis ', International Journal of Gynecology and Obstetrics , vol. 104, no. 3, pp. 244-246. (elsevier.com)
  • RATIONALE: Neutrophilic inflammation is understood to be of pathogenetic importance in chronic obstructive pulmonary disease (COPD) and may be quantified using 18-fluorodeoxyglucose positron emission tomography-computed tomography ((18)FDG PET-CT) as a noninvasive, spatially informative biomarker. (mendeley.com)
  • F18-fluorodeoxyglucose positron emission tomography (FDG-PET), commonly combined with computed tomography (CT), is widely used in the initial evaluation and response assessment of patients with Hodgkin's lymphoma (HL). (touchoncology.com)
  • F18-fluorodeoxyglucose positron emission tomography (FDG-PET) and functional magnetic resonance imaging (fMRI) were performed to gain a further insight in mechanisms underlying these visual sensations and to define a possible focus for therapeutic rTMS. (bmj.com)
  • F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma. (fredhutch.org)
  • F18-fluorodeoxyglucose positron emission tomography (FDG-PET) is a powerful tool to investigate the role of tumor metabolic activity and its suppression by therapy for cancer survival. (fredhutch.org)
  • The purpose of this study was to estimate average radiation exposure from 18F-fluorodeoxyglucose (FDG) positron emission tomography /computed tomography ( PET /CT) examinations and to analyze possible factors affecting the radiation dose . (bvsalud.org)
  • Although hepatoblastoma is the most common malign tumor in childhood in the liver there are few studies including fluorodeoxyglucose positron emission tomography/computed tomography imaging and hepatoblastoma. (scholarena.co)
  • The role of [18F]fluorodeoxyglucose- positron emission tomography (FDG- PET ) in renal cell carcinoma remains to be clearly defined. (bvsalud.org)
  • Detection of bone metastases in cancer-patients by F-18-fluoride and F-18-fluorodeoxyglucose positron emission tomography. (icr.ac.uk)
  • The aim of this study is to compare the diagnostic efficiency of bone scintigraphy, fluorodeoxyglucose (FDG), and sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT) in the evaluation of bone metastasis of the several malignant tumors. (jbstjournal.com)
  • Added value of using a cocktail of F-18 sodium fluoride and F-18 fluorodeoxyglucose in positron emission tomography/computed tomography for detecting bony metastasis: A case report. (jbstjournal.com)
  • Fluorodeoxyglucose (18F) (INN), or fluorodeoxyglucose F 18 (USAN and USP), also commonly called fluorodeoxyglucose and abbreviated [18F]FDG, 18F-FDG or FDG, is a radiopharmaceutical used in the medical imaging modality positron emission tomography (PET). (wikipedia.org)
  • PURPOSE: Fluorine-18-fluorodeoxyglucose-positron emission tomography (FDG-PET) hypometabolism has been used to localize the epileptogenic zone. (biomedsearch.com)
  • Ishida Y, Yoshinaga K, Miyagawa M, Moroi M, Kondoh C, Kiso K, Kumita S. Recommendations for (18)F-fluorodeoxyglucose positron emission tomography imaging for cardiac sarcoidosis: Japanese Society of Nuclear Cardiology recommendations. (springer.com)
  • During the past several years, it has become quite evident that positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) imaging can play a major role in the management of patients with suspected infection. (asm.org)
  • The concept of positron emission tomography (PET) with 18 F-fluorodeoxyglucose (FDG) was born in 1973, when the feasibility of radiolabeling deoxyglucose (DG), a glucose analogue, for in vivo imaging purposes was proposed. (asm.org)
  • F-18 fluorodeoxyglucose positron emission tomography in pulmonary cryptococcoma. (bmj.com)
  • This prospective study evaluated the prognostic significance of 18 F-fluorodeoxyglucose ( 18 F-FDG) uptake in primary non-small cell lung cancer (NSCLC) at positron emission tomography, in a carefully staged population, while correcting for partial volume effects. (aacrjournals.org)
  • Is planar thallium-201/fluorine-18 fluorodeoxyglucose imaging a reasonable clinical alternative to positron emission tomographic myocardial viability scanning? (nii.ac.jp)
  • The purpose is to evaluate the accuracy of integrated 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET)/computed tomography ((CT) with intravenous contrast medium in detecting pelvic and paraaortic lymph node metastasis in patients with uterine cancer, with surgical and histopathological findings used as the reference standard. (semanticscholar.org)
  • Positron Emission Tomography (PET-CT) using F-18 fluorodeoxyglucose (FDG) show reduced metabolism at the site of seizure onset. (wikipedia.org)
  • Expression of GLUT-1 glucose transfer, cellular proliferation activity and grade of tumor correlate with [F-18]-fluorodeoxyglucose uptake by positr. (nih.gov)
  • Myocardial F-18 fluorodeoxyglucose uptake (during hyperinsulinemic glucose clamping) was compared with rest perfusion assessed with early thallium-201 SPECT. (nih.gov)
  • Recently, fluorine-18 (F-18) fluorodeoxyglucose in combination with single-photon emission computed tomography (SPECT) has been proposed to identify viable myocardium, Thallium-201 reinjection and low dose dobutamine echocardiography are used routinely for this purpose. (nih.gov)
  • 18F-fluorodeoxyglucose (FDG) has been useful in the evaluation of myocardial inflammatory processes. (springer.com)
  • Fluorine-18 fluorodeoxyglucose/thallium-201 SPECT was superior to the other techniques in assessing functional recovery. (nih.gov)
  • Fluorodeoxyglucose-PET may identify residual viable tumor when it is otherwise undetectable. (elsevier.com)
  • Stepwise logistic regression indicated that F-18 fluorodeoxyglucose/ thallium-201 was the best predictor. (nih.gov)
  • In hypokinetic segments, the combination of F-18 fluorodeoxyglucose/thallium-201 and low dose dobutamine echocardiography was the best predictor. (nih.gov)
  • The purpose of this study was to evaluate the association of F-18-fluorodeoxyglucose (FDG)-PET/CT findings with the vascular endothelial growth factor (VEGF) family and its receptor (VEGFR) levels in metastatic and nonmetastatic colorectal cancer (CRC). (istanbulc.edu.tr)
  • It is important to remember that not all abnormalities on a fluorodeoxyglucose PET scan are due to malignancy, and unexpected findings may need to be evaluated further. (nps.org.au)
  • Fluorodeoxyglucose F18" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • Fluorodeoxyglucose PET has had a major impact on the management of a broad range of malignancies because it is more sensitive than conventional imaging modalities. (nps.org.au)
  • PET imaging with fluorodeoxyglucose (FDG) is now widely available as an accurate staging tool for NSCLC ( 7 , 8 ). (aacrjournals.org)
  • The main radiotracer in clinical use is F-18 fluorodeoxyglucose. (nps.org.au)
  • The most common radiotracer is F-18 fluorodeoxyglucose (FDG), a molecule similar to glucose. (radiologyinfo.org)
  • 18F-fluorodeoxyglucose (FDG)-PET features of focal nodular hyperplasia (FNH) of the liver. (scholarena.co)
  • multiple myeloma (MM). This study aimed to prospectively assess the clinical utility of ACT PET/CT in MM as compared to the commonly used F18-fluorodeoxyglucose(FDG). (bioportfolio.com)
  • The bone agent, F-18-fluoride and the tumour agent F-18-fluorodeoxyglucose, have been used to evaluate both benign and malignant skeletal disorders qualitatively and quantitatively and the current knowledge with respect to the skeleton in cancer patients is summarised in this article. (icr.ac.uk)
  • 2013) Intracavitary Brachytherapy in Cervical Carcinoma: The Role of F18-FDG-PET in Treatment Planning. (omicsonline.org)
  • This graph shows the total number of publications written about "Fluorodeoxyglucose F18" by people in Harvard Catalyst Profiles by year, and whether "Fluorodeoxyglucose F18" was a major or minor topic of these publication. (harvard.edu)
  • 40 ccr 37 a9552 fluorodeoxyglucose f18 fdg, diagnos ccr x 37 a9580 sodium fluoride f 18,diagnostic. (pdsasa.co.za)
  • CONCLUSIONS: Our preliminary experience suggests that F-fluorodeoxyglucose PET/CT may be clinically beneficial in evaluating fever of unknown origin in children with complicated underlying diseases mandating intensive support in ICUs if usual investigative methods are unsuccessful. (picujournalclub.com)
  • PATIENTS: Nineteen critically ill children (mean age, 5.7 yr old) with complicated underlying diseases requiring intensive care support underwent F-fluorodeoxyglucose PET/CT to evaluate fever of unknown origin. (picujournalclub.com)
  • PURPOSE: We aim to report the quality of accuracy studies investigating the utility of [18F]fluorodeoxyglucose (FDG)-PET in supporting the diagnosis of prodromal Alzheimer's Disease (AD), frontotemporal lobar degeneration (FTLD) and prodromal dementia with Lewy bodies (DLB) in mild cognitive impairment (MCI) subjects, and the corresponding recommendations made by a panel of experts. (elsevier.com)
  • MEASUREMENTS AND MAIN RESULTS: The F-fluorodeoxyglucose PET/CT findings (blinded to the final clinical diagnosis) were compared with final histopathology, culture, serology results, or follow-up imaging. (picujournalclub.com)
  • Here, we report our preliminary experience using F-fluorodeoxyglucose PET/CT in this specific group of patients. (picujournalclub.com)
  • In the other two patients where F-fluorodeoxyglucose PET/CT also showed negative findings, fever subsided shortly thereafter without treatment. (picujournalclub.com)
  • However, there are limited studies about the role of F-fluorodeoxyglucose PET/CT in evaluation of fever of unknown origin in critically ill children, especially those presenting with complicated underlying diseases under treatment. (picujournalclub.com)
  • We evaluated the performance of CD-Well in in vitro measurement and in vivo 18 F-fluorodeoxyglucose and [ 11 C]2-carbomethoxy-3β-(4- fluorophenyl) tropane studies. (fujita-hu.ac.jp)