Heterodimers of FLAVONOIDS bound to LIGNANS.
The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.
A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
A plant genus of the family CHENOPODIACEAE. The extract may be called lochein. Tumbleweed may occasionally refer to AMARANTHUS.
A plant species of the family POACEAE that is widely cultivated for its edible seeds.
A plant genus of the family LAMIACEAE used in folk medicine as a nervine.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells. (1/13)

Extracts from the seeds of milk thistle, Silybum marianum, are known commonly as silibinin and silymarin and possess anticancer actions on human prostate carcinoma in vitro and in vivo. Seven distinct flavonolignan compounds and a flavonoid have been isolated from commercial silymarin extracts. Most notably, two pairs of diastereomers, silybin A and silybin B and isosilybin A and isosilybin B, are among these compounds. In contrast, silibinin is composed only of a 1:1 mixture of silybin A and silybin B. With these isomers now isolated in quantities sufficient for biological studies, each pure compound was assessed for antiproliferative activities against LNCaP, DU145, and PC3 human prostate carcinoma cell lines. Isosilybin B was the most consistently potent suppressor of cell growth relative to either the other pure constituents or the commercial extracts. Isosilybin A and isosilybin B were also the most effective suppressors of prostate-specific antigen secretion by androgen-dependent LNCaP cells. Silymarin and silibinin were shown for the first time to suppress the activity of the DNA topoisomerase IIalpha gene promoter in DU145 cells and, among the pure compounds, isosilybin B was again the most effective. These findings are significant in that isosilybin B composes no more than 5% of silymarin and is absent from silibinin. Whereas several other more abundant flavonolignans do ultimately influence the same end points at higher exposure concentrations, these findings are suggestive that extracts enriched for isosilybin B, or isosilybin B alone, might possess improved potency in prostate cancer prevention and treatment.  (+info)

New insight into the biosynthesis of flavanolignans in the white-flowered variant of Silybum marianum. (2/13)

It has been demonstrated that besides the known flavanolignan constituents of the white-flowered variant of Silybum marianum, (-)-silandrin A (3a) and (-)-isosilandrin A (4a); their trans-benzodioxane diastereomers, (-)-silandrin B (3b) and (-)-isosilandrin B (4b), are also produced by the plant. Moreover, the isolation of their cis-benzodioxane diastereomers, (-)-isocisilandrin (5) and cisilandrin (6), confirm that the previously proposed biosynthetic pathway involving a nonselective O-beta coupling is correct.  (+info)

Hepatic metabolism and biliary excretion of silymarin flavonolignans in isolated perfused rat livers: role of multidrug resistance-associated protein 2 (Abcc2). (3/13)

 (+info)

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships. (4/13)

 (+info)

Substituted pyrazinecarboxamides as abiotic elicitors of flavolignan production in Silybum marianum (L.) gaertn cultures in vitro. (5/13)

 (+info)

Identification of hepatoprotective flavonolignans from silymarin. (6/13)

 (+info)

NF-kappaB inhibitors from Brucea javanica exhibiting intracellular effects on reactive oxygen species. (7/13)

AIM: Brucea javanica was studied to identify nuclear factor kappaB (NF-kappaB) inhibitors exhibiting reactive oxygen species (ROS) intracellular amplification. MATERIAL AND METHODS: Eight compounds were evaluated for selective cytotoxicity using HT-29, HeLa, and HL-60 cells, and in a NF-kappaB assay. Active compounds were then tested using ROS and mitochondria transmembrane potential (MTP) assays. NF-kappaB and nuclear factor activated T-cell (NFAT) translocation were also assessed using their respective whole cell assays. RESULTS: Bruceajavanone B, bruceantin, bruceine A, (-)-hydnocarpin, and chrysoeriol exhibited cytotoxic potential and NF-kappaB p65 inhibition. Chrysoeriol exhibited selective cytotoxicity against leukemia cells with greater potency and also showed an ability to up-regulate NFAT transcriptional pathways through the amplification of intracellular ROS, in the presence of H2O2, to a greater degree than bruceantin and bruceine. CONCLUSION: Chrysoeriol selectively kills leukemic cells and potentiates the amplification of ROS levels. Therefore, chrysoeriol could serve as a potential chemotherapeutic modifier for leukemia chemotherapy since leukemia cells have a higher susceptibility to elevated ROS levels.  (+info)

Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle. (8/13)

 (+info)

Flavanolignans are a type of biologically active compounds that are found in certain plants. They are formed from the combination of flavonoids and lignans, two classes of plant phenolic compounds. One of the most well-known groups of flavanolignans is the one found in milk thistle (Silybum marianum), which includes silibinin, silidianin, and silicristin. These compounds have been studied for their potential antioxidant, anti-inflammatory, and liver-protective effects.

Medical Definition of Milk Thistle:

Milk thistle, also known as Silybum marianum, is a plant that has been used for medicinal purposes for centuries. It belongs to the Asteraceae family and is native to Mediterranean regions. The active compound in milk thistle is silymarin, which is found in the seeds of the plant. Silymarin is a flavonoid complex that contains several components, including silybin, silydianin, and silychristin.

Milk thistle has been traditionally used for its potential benefits in supporting liver health and function. It is believed to have antioxidant, anti-inflammatory, and anti-fibrotic properties that may help protect the liver from damage caused by toxins, viruses, and free radicals. Some studies suggest that milk thistle may also help improve insulin resistance, reduce cholesterol levels, and support brain health.

However, it is important to note that while some research suggests potential benefits of milk thistle for liver health and other conditions, more high-quality studies are needed to confirm these effects and establish recommended dosages. As with any supplement or medication, milk thistle should be used under the guidance of a healthcare provider.

Silymarin is not a medical term itself, but it's the active compound found in the milk thistle plant (Silybum marianum). Medically, silymarin is often referred to as a standardized extract from the seeds of the milk thistle plant. It is a complex mixture of flavonolignans, mainly consisting of silybin, isosilybin, silychristin, and silydianin.

Silymarin has been reported to have various biological activities, including antioxidant, anti-inflammatory, and hepatoprotective effects. It is commonly used in complementary and alternative medicine for the treatment of liver diseases such as hepatitis, cirrhosis, and toxic liver damage due to alcohol or drug abuse. However, its clinical efficacy remains a subject of ongoing research and debate among medical professionals.

"Salsola" is a term that refers to a genus of plants, rather than a medical concept. The plants in this genus are commonly known as Russell or Prickly Pear cactuses, and they are native to Asia, Africa, and Europe. They are not typically associated with medical definitions or conditions. If you have any questions about a specific medical term or condition, I would be happy to help you with that instead!

'Avena sativa' is the scientific name for a type of grass species known as common oat or cultivated oat. It is widely grown as a crop for its seed, which is used as a food source for both humans and animals. Oats are rich in fiber, vitamins, minerals, and antioxidants, making them a popular choice for breakfast cereals, baked goods, and animal feeds. In addition to their nutritional value, oats have also been used in traditional medicine for various purposes, such as treating skin irritation and promoting hair growth.

"Scutellaria" is a genus of plants in the mint family, Lamiaceae. It includes about 350 species, commonly known as skullcaps, that are found worldwide but primarily in temperate regions. Some species of Scutellaria have been used in traditional medicine for various purposes, including treating anxiety, insomnia, and inflammation. However, it is important to note that the effectiveness and safety of using these plants for medicinal purposes have not been thoroughly studied and are not established by scientific evidence. Therefore, it is recommended to consult with a healthcare professional before using any herbal remedies.

An encyclopedia is a comprehensive reference work containing articles on various topics, usually arranged in alphabetical order. In the context of medicine, a medical encyclopedia is a collection of articles that provide information about a wide range of medical topics, including diseases and conditions, treatments, tests, procedures, and anatomy and physiology. Medical encyclopedias may be published in print or electronic formats and are often used as a starting point for researching medical topics. They can provide reliable and accurate information on medical subjects, making them useful resources for healthcare professionals, students, and patients alike. Some well-known examples of medical encyclopedias include the Merck Manual and the Stedman's Medical Dictionary.

Flavonolignans are natural phenols composed of a part flavonoid and a part phenylpropane. Flavonolignans identified in Silybum ... Look up flavonolignan in Wiktionary, the free dictionary. v t e (CS1 Japanese-language sources (ja), PubChem ID (CID) not in ... Three flavonolignans derived from the flavone tricin have been isolated from the herb Avena sativa. Palstatin has been isolated ... The flavonolignans tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether and tricin 4'-O-(threo-beta-guaiacylglyceryl) ether can be ...
Three flavonolignans derived from tricin have been isolated from oats Avena sativa. The rice bran constituent tricin potently ... Wenzig, Eva (2005). "Flavonolignans from Avena sativa". Journal of Natural Products. 68 (2): 289-292. doi:10.1021/np049636k. ...
Herbalism Pharmacognosy Flavonolignan "Lignans". Micronutrient Information Center, Linus Pauling Institute, Oregon State ...
Rhodiolin, a flavonolignan, is the product of the oxidative coupling of coniferyl alcohol with the 7,8-dihydroxy grouping of ... A flavonolignan and glycosides of herbacetin". Chemistry of Natural Compounds. 19: 21-29. doi:10.1007/BF00579955. S2CID 7656479 ...
"Flavonolignans from silymarin modulate antibiotic resistance and virulence in Staphylococcus aureus". Biomedicine & ...
Flavonolignans - e.g. silymarin - a mixture of flavonolignans extracted from milk thistle. Capsaicin, the active component of ...
All of the flavonolignan compounds found in the silymarin mixture seem to block the uptake of thyroid hormones into the cells ... Silychristin is a flavonolignan, along with many other silymarin constituents (such as silybin, isosilybin, silydianin, etc.), ... Natural flavonolignans, which include silychristin, are biosynthesized by the oxidative coupling of a flavonoid and a ... It is estimated that up to 65-80% of silymarin extract is made up of flavonolignans, like silychristin, which give silymarin ...
Cinchonain-Ib is a flavonolignan found in the bark of T. catigua. Beltrame, F. L.; Filho, E. R.; Barros, F. A. P.; Cortez, D. A ...
... is a flavonolignan found in the bark of Trichilia catigua used as catuaba. A 2009 study revealed that Cinchonian- ... Flavonolignans, All stub articles, Aromatic compound stubs). ...
2005). "Milk Thistle and Prostate Cancer: Differential Effects of Pure Flavonolignans from Silybum marianum on ... a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8". Endocrinology. ... containing a mixture of flavonolignans consisting of silibinin, isosilibinin, silychristin, silidianin, and others. Silibinin ...
All of the flavonolignan compounds found in the silymarin mixture seem to block the uptake of thyroid hormones into the cells ... a Flavonolignan Derived From the Milk Thistle, Is a Potent Inhibitor of the Thyroid Hormone Transporter MCT8". Endocrinology. ...
Effect of sowing date and rate on the yield and flavonolignan content of the fruits of milk thistle (Silybum marianum L. Gaertn ... The extract consists of about 65-80% silymarin (a flavonolignan complex) and 20-35% fatty acids, including linoleic acid. ... Silymarin is a complex mixture of polyphenolic molecules, including seven closely related flavonolignans (silybin A, silybin B ...
... can combine to form a hybrid class like the flavonolignans. Nomenclature of polymers: Plants in the genus Humulus and Cannabis ...
... flavonolignans MeSH D03.438.150.266.450.268.777 - silymarin MeSH D03.438.150.266.450.284 - flavonols MeSH D03.438.150.266. ... flavonolignans MeSH D03.830.219.266.450.268.777 - silymarin MeSH D03.830.219.266.450.284 - flavonols MeSH D03.830.219.266. ...
... flavonolignans MeSH D02.455.426.559.389.140.450.582 - nordihydroguaiaretic acid MeSH D02.455.426.559.389.140.450.777 - ...
Flavonolignans are natural phenols composed of a part flavonoid and a part phenylpropane. Flavonolignans identified in Silybum ... Look up flavonolignan in Wiktionary, the free dictionary. v t e (CS1 Japanese-language sources (ja), PubChem ID (CID) not in ... Three flavonolignans derived from the flavone tricin have been isolated from the herb Avena sativa. Palstatin has been isolated ... The flavonolignans tricin 4-O-(erythro-beta-guaiacylglyceryl) ether and tricin 4-O-(threo-beta-guaiacylglyceryl) ether can be ...
Analysis of Silymarin Flavonolignans.. The simultaneous analysis of the major free (i.e., nonconjugated) flavonolignans silybin ... that disposition of flavonolignans may be altered (Schrieber et al., 2011). Indeed, plasma concentrations of the flavonolignans ... 2010) Two flavonolignans from milk thistle (Silybum marianum) inhibit CYP2C9-mediated warfarin metabolism at clinically ... In a human liver microsome incubation study, silybin B was determined to be the most potent flavonolignan for the inhibition of ...
Flavonolignan 2,3-dehydroderivatives: Preparation, antiradical and cytoprotective activity. Free Radic. Biol. Med. 2016, 90, ... Enzymatic oxidative dimerization of silymarin flavonolignans. J. Mol. Catal. B-Enzym. 2014, 109, 24-30. [Google Scholar] [ ...
Biosynthesis and Regulation of Antioxidant Flavonolignans in Milk Thistle By Samantha Drouet and Christophe Hano ... a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. Their biological activities in relation with ...
... a flavonolignan from milk thistle (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 ... Silymarin, a flavonolignan from milk thistle (Silybum marianum) plant is used almost exclusively for hepatoprotection and ... Silymarin consists of four flavonolignan isomers namely--silybin, isosilybin, silydianin and silychristin. Among them, silybin ...
A flavonolignan isolated from milk thistle, ,ital,Silybum marianum,/ital,, that has been shown to exhibit antioxidant and ... A flavonolignan isolated from milk thistle, Silybum marianum, that has been shown to exhibit antioxidant and antineoplastic ...
The seed extract has numerous potent flavonolignans that can benefit the organ. At the same time, silymarin has the highest ...
Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Cons.... 2010. Graf, Tyler Faculty. ... Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Cons.... 2010. Oberlies, Nicholas ...
2]), mururin A, a flavonolignan with absorbance maxima between 220 and 393 nm [23], [30]. Both total ethanolic extract and the ...
Single Laboratory Validation of UHPLC-MS/MS Assays for Six Milk Thistle Flavonolignans in Human Serum.. J AOAC Int. ...
Silibinin, the major flavonolignan isolated from S. marianum, has been reported as a promising therapeutic agent for different ... Silibinin, a flavonolignan isolated from Silybum marianum L. Gaertn., has been extensively utilized in the treatment of liver ...
The radioprotective efficacy of Silymarin as a dietary supplement comprises of a mixture of flavonolignans containing silybin ( ...
Angiopreventive efficacy of pure flavonolignans from milk thistle extract against prostate cancer: targeting VEGF-VEGFR ...
... containing a mixture of flavonolignans that consist of silibinin, isosilibinin, silicristin, and silidianin. Silibinin itself ...
Svobodova A, Zdarilova A, Walterova D, Vostalova J. Flavonolignans from Silybum marianum moderate UVA-induced oxidative damage ...
Made up of silybins A and B, it is the most biologically active flavonolignan component found in milk thistle extract. Its ...
Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and flavonolignan ternary complexes by ...
Silymarin: Silybins A&B, silychristin, and silydianin are just some of the complex mixture of flavonolignan molecules ...
Genistein and other isoflavones have been identified as angiogenesis inhibitors, and found to inhibit the uncontrolled cell growth of cancer, most likely by inhibiting the activity of substances in the body that regulate cell division and cell survival (growth factors). Various studies have found that moderate doses of genistein have inhibitory effects on cancers of the prostate,[39][40] cervix,[41] brain,[42] breast[39][43][44] and colon.[17] It has also been shown that genistein makes some cells more sensitive to radio-therapy.;[45] although, timing of phytoestrogen use is also important.[45] Genisteins chief method of activity is as a tyrosine kinase inhibitor. Tyrosine kinases are less widespread than their ser/thr counterparts but implicated in almost all cell growth and proliferation signal cascades. Inhibition of DNA topoisomerase II also plays an important role in the cytotoxic activity of genistein.[27][46] The observation that transition of normal lymphocytes from quiescence (G0) to ...
Preparation of Retinoyl-Flavonolignan Hybrids and Their Antioxidant Properties. Christopher S. Chambers, David Biedermann, ...
This compound belongs to the class of organic compounds known as flavonolignans. These are non-conventional lignans that ...
result sql = Flavonolignans. Flavonolignans 35. char = E;code = 69. char = n;code = 110. char = z;code = 122. char = y;code = ...
"Salicylic acid increases flavonolignans accumulation in the fruits of hydroponically cultured Silybum marianum". Saudi ...
A supplementary source of flavonolignans. Cleanses the.... €17.20 Add to cart Quick view More info ...
Flavonolignans Calculated As Silybin 572mcg); Ginkgo (Ginkgo Biloba) Dry Leaf 5mg (Equiv. Ginkgolides & Bilobalide 6mcg, Ginkgo ...
Silibinin (Figure 1) is a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle, and has a wide ... Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk ...
Pharmacokinetics of a New Flavonolignan Complex (IdB 1016), (Siliphos®), Following Single and Multiple Doses in Man. N. ...
Skin Protective Activity of Silymarin and its Flavonolignans. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6470681/ ...
... active ingredients of silymarin flavonolignans. Throughout the trial, silymarin effectively slowed the progression of HFS. By ... Skin protective activity of silymarin and its flavonolignans. Molecules, 24(6), 1022. ...
  • Silybum marianum in vitro-flavonolignan production" (PDF). (wikipedia.org)
  • Mature fruits (achenes) of milk thistle (Silybum marianum (L.) Gaertner, Asteraceae) accumulate high amounts of silymarin, a complex mixture of bioactive antioxidant flavonolignans deriving from taxifolin. (intechopen.com)
  • Silymarin, a flavonolignan from 'milk thistle' (Silybum marianum) plant is used almost exclusively for hepatoprotection and amounts to 180 million US dollars business in Germany alone. (nih.gov)
  • Large-Scale Isolation of Flavonolignans from Silybum marianum Extract Affords New Minor Cons. (uncg.edu)
  • Here, we investigated the effect of silibinin (a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle) on the epidermal growth factor (EGF) ligand-induced CD44 expression in human breast cancer cells. (iiarjournals.org)
  • Silibinin ( Figure 1 ) is a polyphenolic flavonolignan of the herbal plant of Silybum marianum, milk thistle, and has a wide range of pharmacologic effects, such as antihepatotoxic and anticarcinogenic in a variety of tumor cells ( 4 , 5 ). (iiarjournals.org)
  • Silymarin is a flavonolignans extracted from the milk thistle Silybum marianum (L.) gaernt. (thehouseofgoodies.com)
  • 2020. Single Laboratory Validation of UHPLC-MS/MS Assays for Six Milk Thistle Flavonolignans in Human Serum. . (oregonstate.edu)
  • New brominated derivatives of silymarin flavonolignans and related flavonoids were prepared. (cas.cz)
  • Silymarin composed of six flavonolignans that Silibinin, with 40-50, is the most one. (ac.ir)
  • Silymarin consists of four flavonolignan isomers namely--silybin, isosilybin, silydianin and silychristin. (nih.gov)
  • Silymarin, as well as an isolated form of flavonolignan known as silybin, can support a healthy liver and promote the body's natural ability to combat toxins such as alcohol, environmental toxins and poisons. (holographichealth.com)
  • This review focuses on recent developments in chemistry, biosynthesis, modern advanced analytical methods, and transformations of flavonolignans specifically reflecting their chirality. (cas.cz)
  • 1. Novel flavonolignan hybrid antioxidants: From enzymatic preparation to molecular rationalization. (upol.cz)
  • Moreover, it is now clear that flavonolignans do not act as antioxidants in vivo, but as specific ligands of biological targets and therefore their chirality is crucial. (cas.cz)
  • A growing number of studies show that the respective diastereomers of flavonolignans have significantly different activities in anisotropic biological systems. (cas.cz)
  • The active constituents of milk thistle supplements are believed to be the flavonolignans contained within the extracts. (aspetjournals.org)
  • The name silymarin is a general term for the active chemicals known as flavonolignans. (holographichealth.com)
  • Silymarin (the mixture of flavonolignans extracted from Silybum marianum) has potentially beneficial antioxidant properties. (nih.gov)
  • Silymarin is a flavonolignan that has been introduced fairly recently as a hepatoprotective agent. (medscape.com)
  • Phytochemistry analysis revealed an abundance of active constituents, particularly silymarin, composed of polyphenols and flavonolignans. (nih.gov)
  • Silymarin is majorly found in leaves, seeds, and fruits and is comprised of seven flavonolignans. (nih.gov)
  • The active complex of MT is a lipophilic extract from the seeds of the plant and is composed of three isomer flavonolignans (silybin, silydianin, and silychristin) collectively known as silymarin. (nih.gov)
  • The plant's healing abilities may come from a mixture of flavonolignans called "silymarin" and its main element, which is called "silybinin. (healthline.com)
  • Milk thistle products are typically either an extract of milk thistle, termed silymarin, or a phytosome preparation of the two major flavonolignans. (nih.gov)
  • The benefits of this plant come from its silymarin content-a mixture of chemicals known as flavonolignans. (wholefoodsmagazine.com)
  • Silymarin contains a group of closely-related flavonolignan compounds including silibinin, and is extracted from Silybum marianum species, also called milk thistle. (nih.gov)
  • The herb is derived from the hard fruits of the Silybum marianum plant, and contains a substance called Silymarin, which is a group of flavonolignans. (narsto.org)
  • Silybin and the other silymarin flavonolignans from milk thistle conserve tissue glutathione, are liver-protective, and have anticancer potential. (altmedrev.com)
  • Silymarin is the key component of S. marianum and includes flavonolignans (silibinin, isosilibinin, silychristin, isosilychristin, and silydianin) and a flavonoid (taxifolin). (genominfo.org)
  • The name silymarin is a general term for the active chemicals known as flavonolignans. (opc3.com)
  • Silymarin, as well as an isolated form of flavonolignan known as silybin, can support a healthy liver and promote the body's natural ability to combat toxins such as alcohol, environmental toxins and poisons. (opc3.com)
  • Silymarin is not a single component but a complex of chemicals known as flavonolignans. (herbhealer.net)
  • The substance contains silymarin and silibinin, vital flavonolignans that basically help your liver regenerate faster. (madebykatiebug.com)
  • The active compound in milk thistle is silymarin, a complex of flavonolignans including silybin, silydianin, and silychristin. (portlandclinicofnaturalhealth.com)
  • Silymarin is a mixture of flavonolignans extracted from the seeds of the milk thistle plant (Silybum marianum). (rcd.bio)
  • The plant's seeds contain fatty acids and proteins, as well as silymarin, a mixture of flavonolignans, which is what makes it so effective. (karpasia-hp.com)
  • Silibinin, also known as silybin, is the major active constituent of silymarin, a standardized milk thistle seeds standardized extract containing a mixture of flavonolignans consisting of silibinin and isosilibinin. (icliniq.com)
  • Designed to reduce the toxic load in your body and relieve occasional constipation, CleanseSMART® also contains silymarin, a mixture of flavonolignans isolated from the botanical seed milk thistle, an herbal ingredient traditionally used for liver protection. (durhamnaturals.com)
  • Flavonolignans Calculated As Silybin 28.6mg) 2.5g, Turmeric (Curcuma longa) Rhizome (Equiv. (abetterme.co.nz)
  • Milk thistle has a wide safety margin which has led to an array of commercially available milk thistle products with different recommended doses and/or formulations designed to increase systemic concentrations of the major bioactive constituents, flavonolignans. (nih.gov)
  • The flavonolignans tricin 4'-O-(erythro-beta-guaiacylglyceryl) ether and tricin 4'-O-(threo-beta-guaiacylglyceryl) ether can be isolated together with their 7-O-glucosides in the leaves of Hyparrhenia hirta. (wikipedia.org)
  • Flavonolignans are natural phenols composed of a part flavonoid and a part phenylpropane. (wikipedia.org)
  • Three flavonolignans derived from the flavone tricin have been isolated from the herb Avena sativa. (wikipedia.org)
  • First, we will characterize the roles of OATPs in milk thistle flavonolignan disposition through in vitro kinetic experiments (study 1.1) and in vivo pharmacokinetic experiments in OATP humanized mice (study 1.2). (nih.gov)