Free Radical Scavengers
Any compound that contains a constituent sugar, in which the hydroxyl group attached to the first carbon is substituted by an alcoholic, phenolic, or other group. They are named specifically for the sugar contained, such as glucoside (glucose), pentoside (pentose), fructoside (fructose), etc. Upon hydrolysis, a sugar and nonsugar component (aglycone) are formed. (From Dorland, 28th ed; From Miall's Dictionary of Chemistry, 5th ed)
Polyphenolic compounds with molecular weights of around 500-3000 daltons and containing enough hydroxyl groups (1-2 per 100 MW) for effective cross linking of other compounds (ASTRINGENTS). The two main types are HYDROLYZABLE TANNINS and CONDENSED TANNINS. Historically, the term has applied to many compounds and plant extracts able to render skin COLLAGEN impervious to degradation. The word tannin derives from the Celtic word for OAK TREE which was used for leather processing.
Chromatography, High Pressure Liquid
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (DNA TOPOISOMERASES, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 PHASE arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
A large plant family of the order Asterales, subclass Asteridae, class Magnoliopsida. The family is also known as Compositae. Flower petals are joined near the base and stamens alternate with the corolla lobes. The common name of "daisy" refers to several genera of this family including Aster; CHRYSANTHEMUM; RUDBECKIA; TANACETUM.
Drugs, Chinese Herbal
Oils which evaporate readily. The volatile oils occur in aromatic plants, to which they give odor and other characteristics. Most volatile oils consist of a mixture of two or more TERPENES or of a mixture of an eleoptene (the more volatile constituent of a volatile oil) with a stearopten (the more solid constituent). The synonym essential oils refers to the essence of a plant, as its perfume or scent, and not to its indispensability.
Glycosides of GLUCURONIC ACID formed by the reaction of URIDINE DIPHOSPHATE GLUCURONIC ACID with certain endogenous and exogenous substances. Their formation is important for the detoxification of drugs, steroid excretion and BILIRUBIN metabolism to a more water-soluble compound that can be eliminated in the URINE and BILE.
Inhibitory Concentration 50
Genus of perennial plants in the family CLUSIACEAE (sometimes classified as Hypericaceae). Herbal and homeopathic preparations are used for depression, neuralgias, and a variety of other conditions. Hypericum contains flavonoids; GLYCOSIDES; mucilage, TANNINS; volatile oils (OILS, ESSENTIAL), hypericin and hyperforin.
The large family of plants characterized by pods. Some are edible and some cause LATHYRISM or FAVISM and other forms of poisoning. Other species yield useful materials like gums from ACACIA and various LECTINS like PHYTOHEMAGGLUTININS from PHASEOLUS. Many of them harbor NITROGEN FIXATION bacteria on their roots. Many but not all species of "beans" belong to this family.
Spectrometry, Mass, Electrospray Ionization
A mass spectrometry technique used for analysis of nonvolatile compounds such as proteins and macromolecules. The technique involves preparing electrically charged droplets from analyte molecules dissolved in solvent. The electrically charged droplets enter a vacuum chamber where the solvent is evaporated. Evaporation of solvent reduces the droplet size, thereby increasing the coulombic repulsion within the droplet. As the charged droplets get smaller, the excess charge within them causes them to disintegrate and release analyte molecules. The volatilized analyte molecules are then analyzed by mass spectrometry.
A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant.
Dose-Response Relationship, Drug
A sweet viscous liquid food, produced in the honey sacs of various bees from nectar collected from flowers. The nectar is ripened into honey by inversion of its sucrose sugar into fructose and glucose. It is somewhat acidic and has mild antiseptic properties, being sometimes used in the treatment of burns and lacerations.
Antineoplastic Agents, Phytogenic
A large plant family in the order Apiales, also known as Umbelliferae. Most are aromatic herbs with alternate, feather-divided leaves that are sheathed at the base. The flowers often form a conspicuous flat-topped umbel. Each small individual flower is usually bisexual, with five sepals, five petals, and an enlarged disk at the base of the style. The fruits are ridged and are composed of two parts that split open at maturity.
An organism of the vegetable kingdom suitable by nature for use as a food, especially by human beings. Not all parts of any given plant are edible but all parts of edible plants have been known to figure as raw or cooked food: leaves, roots, tubers, stems, seeds, buds, fruits, and flowers. The most commonly edible parts of plants are FRUIT, usually sweet, fleshy, and succulent. Most edible plants are commonly cultivated for their nutritional value and are referred to as VEGETABLES.
A plant genus of the family FABACEAE. The common name of "Bird-Of-Paradise" is also used for other plants such as Heliconia (HELICONIACEAE) and Strelitzia (STRELITZIACEAE) and some birds. The common name of "Cat's-Claw" is more often used with UNCARIA. The common name of "Pernambuco" also refers to a state in Brazil. Furanoditerpenoid lactones and caesalpin are produced by members of this genus.
An investigation into the binding of the carcinogen 15,16-dihydro-11-methylcyclopenta[a]phenanthren-17-one to DNA in vitro. (1/5753)After metabolic activation the carcinogen 15,16-dihydro-11-[3H]methylcyclopenta[a]phenanthren-17-one binds to DNA in vitro, and this binding is prevented by 7,8-benzoflavone. Radioactivity cannot be removed from the DNA with organic solvents or by chromatography on Sephadex G-50, even after heat denaturation of the DNA. Enzymatic hydrolysis yields radioactive fractions, which elute from a column of Sephadex LH-20 immediately after the natural nucleosides. At least two species of reactive metabolites are involved in this bending, those with a half-life of a few hr and others with greater stability. After extraction from the aqueous incubation mixture, they could be detected in discrete polar fractions from separations of the complex metabolite mixture by high-pressure liquid chromatography. Their ability to bind to DNA decreased with time at ambient temperature, and they were rapidly deactivated by acid. 7,8-Benzolflavone acted by suppressing the formation of polar metabolites derived from enzymatic oxidation of the aromatic double bonds. The inhibitor had no effect on the enzymes hydroxylating saturated carbon; hence it is unlikely that metabolism of the methyl group is important in conversion of this carcinogen to its proximate form, although the presence of the 11-methyl group is essential for carcinogenic activity in this series. (+info)
The direct spectrophotometric observation of benzo(a)pyrene phenol formation by liver microsomes. (2/5753)Optical spectral repetitive scan analysis during the oxidative metabolism of benzo(a)pyrene by liver microsomal suspensions reveals the time-dependent formation of an intermediate(s) of which the visible spectra resemble those of several benzo(a)pyrene phenols. Liver microsomes from 3-methylcholanthrene-treated rats showed a greater rate of formation of the phenols than did microsomes from control animals; the rate of formation catalyzed by liver microsomes from phenobarbital-pretreated rats was intermediate. When 3-hydroxybenzo(a)pyrene was used as a standard for comparison of activity, the rates of formation of phenols were compared when measured by fluorometric, spectrophotometric, or high-pressure liquid chromatographic analytical techniques. An epoxide hydrase inhibitor, 1,1,1-trichloropropene-2,3-oxide, enhanced phenol formation regardless of the source of liver microsomes, and 7,8-benzoflavone inhibited control and 3-methylcholanthrene-induced microsomal metabolism of benzo(a)pyrene, 7,8-Benzoflavone did not effect benzo(a)pyrene metabolism by liver microsomes from phenobarbital-pretreated rats. The effect of inhibitors on the spectrophotometric assay correlates well with the results obtained from benzo(a)pyrene metabolite analysis using high-pressure liquid chromatography. (+info)
The MAP kinase ERK2 inhibits the cyclic AMP-specific phosphodiesterase HSPDE4D3 by phosphorylating it at Ser579. (3/5753)The extracellular receptor stimulated kinase ERK2 (p42(MAPK))-phosphorylated human cAMP-specific phosphodiesterase PDE4D3 at Ser579 and profoundly reduced ( approximately 75%) its activity. These effects could be reversed by the action of protein phosphatase PP1. The inhibitory state of PDE4D3, engendered by ERK2 phosphorylation, was mimicked by the Ser579-->Asp mutant form of PDE4D3. In COS1 cells transfected to express PDE4D3, challenge with epidermal growth factor (EGF) caused the phosphorylation and inhibition of PDE4D3. This effect was blocked by the MEK inhibitor PD98059 and was not apparent using the Ser579-->Ala mutant form of PDE4D3. Challenge of HEK293 and F442A cells with EGF led to the PD98059-ablatable inhibition of endogenous PDE4D3 and PDE4D5 activities. EGF challenge of COS1 cells transfected to express PDE4D3 increased cAMP levels through a process ablated by PD98059. The activity of the Ser579-->Asp mutant form of PDE4D3 was increased by PKA phosphorylation. The transient form of the EGF-induced inhibition of PDE4D3 is thus suggested to be due to feedback regulation by PKA causing the ablation of the ERK2-induced inhibition of PDE4D3. We identify a novel means of cross-talk between the cAMP and ERK signalling pathways whereby cell stimuli that lead to ERK2 activation may modulate cAMP signalling. (+info)
Salmonella typhimurium and lipopolysaccharide stimulate extracellularly regulated kinase activation in macrophages by a mechanism involving phosphatidylinositol 3-kinase and phospholipase D as novel intermediates. (4/5753)Activation of the extracellularly regulated kinase (ERK) pathway is part of the early biochemical events that follow lipopolysaccharide (LPS) treatment of macrophages or their infection by virulent and attenuated Salmonella strains. Phagocytosis as well as the secretion of invasion-associated proteins is dispensable for ERK activation by the pathogen. Furthermore, the pathways used by Salmonella and LPS to stimulate ERK are identical, suggesting that kinase activation might be solely mediated by LPS. Both stimuli activate ERK by a mechanism involving herbimycin-dependent tyrosine kinase(s) and phosphatidylinositol 3-kinase. Phospholipase D activation and stimulation of protein kinase C appear to be intermediates in this novel pathway of MEK/ERK activation. (+info)
Role of the extracellular signal-regulated protein kinase cascade in human neutrophil killing of Staphylococcus aureus and Candida albicans and in migration. (5/5753)Killing of Staphylococcus aureus and Candida albicans by neutrophils involves adherence of the microorganisms, phagocytosis, and a collaborative action of oxygen reactive species and components of the granules. While a number of intracellular signalling pathways have been proposed to regulate neutrophil responses, the extent to which each pathway contributes to the killing of S. aureus and C. albicans has not been clearly defined. We have therefore examined the effect of blocking one such pathway, the extracellular signal-regulated protein kinase (ERK) cascade, using the specific inhibitor of the mitogen-activated protein kinase/ERK kinase, PD98059, on the ability of human neutrophils to kill S. aureus and C. albicans. Our data demonstrate the presence of ERK2 and a 43-kDa form of ERK but not ERK1 in human neutrophils. Upon stimulation with formyl methionyl leucyl phenylalanine (fMLP), the activities of both ERK2 and the 43-kDa form were stimulated. Despite abrogating the activity of both ERK forms, PD98059 only slightly reduced the ability of neutrophils to kill S. aureus or C. albicans. This is consistent with our finding that PD98059 had no effect on neutrophil adherence or degranulation, although pretreatment of neutrophils with PD98059 inhibited fMLP-stimulated superoxide production by 50%, suggesting that a change in superoxide production per se is not strictly correlated with microbicidal activity. However, fMLP-stimulated chemokinesis was markedly inhibited, while random migration and fMLP-stimulated chemotaxis were partially inhibited, by PD98059. These data demonstrate, for the first time, that the ERK cascade plays only a minor role in the microbicidal activity of neutrophils and that the ERK cascade is involved primarily in regulating neutrophil migration in response to fMLP. (+info)
Tissue factor pathway inhibitor-2 is a novel mitogen for vascular smooth muscle cells. (6/5753)A mitogen for growth-arrested cultured bovine aortic smooth muscle cells was purified to homogeneity from the supernatant of cultured human umbilical vein endothelial cells by heparin affinity chromatography and reverse-phase high performance liquid chromatography. This mitogen was revealed to be tissue factor pathway inhibitor-2 (TFPI-2), which is a Kunitz-type serine protease inhibitor. TFPI-2 was expressed in baby hamster kidney cells using a mammalian expression vector. Recombinant TFPI-2 (rTFPI-2) stimulated DNA synthesis and cell proliferation in a dose-dependent manner (1-500 nM). rTFPI-2 activated mitogen-activated protein kinase (MAPK) activity and stimulated early proto-oncogene c-fos mRNA expression in smooth muscle cells. MAPK, c-fos expression and the mitogenic activity were inhibited by a specific inhibitor of MAPK kinase, PD098059. Thus, the mitogenic function of rTFPI-2 is considered to be mediated through MAPK pathway. TFPI has been reported to exhibit antiproliferative action after vascular smooth muscle injury in addition to the ability to inhibit activation of the extrinsic coagulation cascade. However, structurally similar TFPI-2 was found to have a mitogenic activity for the smooth muscle cell. (+info)
Influence of tangeretin on tamoxifen's therapeutic benefit in mammary cancer. (7/5753)BACKGROUND: Tamoxifen and the citrus flavonoid tangeretin exhibit similar inhibitory effects on the growth and invasive properties of human mammary cancer cells in vitro; furthermore, the two agents have displayed additive effects in vitro. In this study, we examined whether tangeretin would enhance tamoxifen's therapeutic benefit in vivo. METHODS: Female nude mice (n = 80) were inoculated subcutaneously with human MCF-7/6 mammary adenocarcinoma cells. Groups of 20 mice were treated orally by adding the following substances to their drinking water: tamoxifen (3 x 10(-5) M), tangeretin (1 x 10(-4) M), tamoxifen plus tangeretin (3 x 10(-5) M plus 1 x 10(-4) M), or solvent. RESULTS AND CONCLUSIONS: Oral treatment of mice with tamoxifen resulted in a statistically significant inhibition of tumor growth compared with solvent treatment (two-sided P = .001). Treatment with tangeretin did not inhibit tumor growth, and addition of this compound to drinking water with tamoxifen completely neutralized tamoxifen's inhibitory effect. The median survival time of tumor-bearing mice treated with tamoxifen plus tangeretin was reduced in comparison with that of mice treated with tamoxifen alone (14 versus 56 weeks; two-sided P = .002). Tangeretin (1 x 10(-6) M or higher) inhibited the cytolytic effect of murine natural killer cells on MCF-7/6 cells in vitro, which may explain why tamoxifen-induced inhibition of tumor growth in mice is abolished when tangeretin is present in drinking water. IMPLICATIONS: We describe an in vivo model to study potential interference of dietary compounds, such as flavonoids, with tamoxifen, which could lead to reduced efficacy of adjuvant therapy. In our study, the tumor growth-inhibiting effect of oral tamoxifen was reversed upon addition of tangeretin to the diet. Our data argue against excessive consumption of tangeretin-added products and supplements by patients with mammary cancer during tamoxifen treatment. (+info)
Thrombopoietin-induced conformational change in p53 lies downstream of the p44/p42 mitogen activated protein kinase cascade in the human growth factor-dependent cell line M07e. (8/5753)Thrombopoietin is a cytokine with potent megakaryocytopoietic and thrombopoietic activities in vivo. Wild-type p53 is a conformationally flexible, anti-oncogenic transcription factor that plays a principal role in mediating growth factor withdrawal-induced apoptosis in factor-dependent hematopoietic cells. We recently reported that Tpo induces a conformational change in and functional inactivation of p53, coincident with its anti-apoptotic effects, in the human factor-dependent cell line M07e. In an effort to identify potential signaling cascades through which Tpo illicits these effects on p53, we report here that treating M07e cells with MAPK kinase inhibitor PD98059 dramatically suppressed Tpo-induced conformational change in p53 as well as Tpo-enhanced viability in M07e cells in a p53-dependent manner. Furthermore, the expression of constitutively active Raf1 in M07e cells induced conformational change in p53 independent of Tpo stimulation. Inhibition of the JAK/STAT pathway revealed that JAK/STAT signaling plays an insignificant role in conformational modulation of p53 and apoptosis suppression. Inhibition of phosphatidylinositol-3 kinase did not have a significant effect on p53 conformation but did have a weak but significant effect on Tpo-enhanced viability. Cytokine-induced activation of the MAPK pathway and the subsequent functional neutralization of p53, may be an event by which apoptosis is commonly suppressed in hematopoiesis. (+info)
Flavonoids | ENCOGNITIVE.COM
Flavonoids are a large family of compounds synthesized by plants that have a common chemical structure (1). The basic structure of a flavonoid is shown in figure 1. Flavonoids may be further divided into subclasses (see table 1). Over the past decade, scientists have become increasingly interested in the potential for various dietary flavonoids to explain some of the health benefits associated with fruit and vegetable-rich diets. These potential health benefits are being used to promote the consumption of flavonoid-rich foods, beverages and dietary supplements. This article reviews the scientific evidence for the hypothesis that dietary flavonoids promote health and prevent disease in humans. For more detailed information on the health effects of isoflavones, a subclass of flavonoids with estrogenic activity, see the separate article on Soy Isoflavones. For more information on the health benefits of foods that are rich in flavonoids, see separate articles on Fruits and Vegetables, Legumes and ...
How Dietary Flavonoids can Prevent Neurodegenerative Disease - MS Cure Fund
The mechanisms behind flavonoid-related neuroprotection. Improved vascular function. The general health benefits of flavonoids have been suggested to reach far and wide, and that includes lowering blood pressure and improving appropriate arterial dilation. Vascular health is vital to the brain, where cerebral blood flow needs to be maintained for proper cognitive function. Findings indicate that flavonoids can improve vascular blood flow in the brain. For instance, brain imaging demonstrated that flavonoid-rich cocoa can significantly improve cerebral blood flow when healthy older adults were given cognitive tasks. Another significant benefit of enhanced brain vascular function is the formation of new neurons, particularly in the hippocampus - the brains memory centre. Therefore, flavonoids have the potential to not only slow cognitive decline in those with pathological neurodegeneration, but they could even reverse it too.. Anti-inflammatory effects. Chronically raised levels of ...
Eating Flavonoids Protects Men Against Parkinsons Disease - Redorbit
Men who eat flavonoid-rich foods such as berries, tea, apples and red wine significantly reduce their risk of developing Parkinsons disease, according to new research by Harvard University and the University of East Anglia (UEA).. Published today in the journal Neurology ®, the findings add to the growing body of evidence that regular consumption of some flavonoids can have a marked effect on human health. Recent studies have shown that these compounds can offer protection against a wide range of diseases including heart disease, hypertension, some cancers and dementia.. This latest study is the first study in humans to show that flavonoids can protect neurons against diseases of the brain such as Parkinsons.. Around 130,000 men and women took part in the research. More than 800 had developed Parkinsons disease within 20 years of follow-up. After a detailed analysis of their diets and adjusting for age and lifestyle, male participants who ate the most flavonoids were shown to be 40 per cent ...
Dietary flavonoid intakes in early postmenopausal Scottish women<...
TY - JOUR. T1 - Dietary flavonoid intakes in early postmenopausal Scottish women. AU - Hardcastle, Antonia C. AU - Kyle, Janet. AU - Duthie, Garry. AU - McNeill, Geraldine. AU - Reid, David M. AU - Macdonald, Helen M. N1 - Meeting abstract. PY - 2005/1. Y1 - 2005/1. U2 - 10.1079/PNS2004XXX. DO - 10.1079/PNS2004XXX. M3 - Abstract. VL - 64. SP - 85A. JO - Proceedings of the Nutrition Society. JF - Proceedings of the Nutrition Society. SN - 0029-6651. IS - 1a. ER - ...
Optimization Of Extraction Condition And Quantification Of Total Flavonoids In Elaeagni Folium
Introduction: Elaeagni Folium has been used as a crude drug to cure lung deficiency cough, asthma and shortness of breath for a long time in China. The research aimed to optimize the extraction condition and measure the amount of total flavonoids in this medicinal material. Methods: Reflux extraction was an efficient method, compared with sonication and soxhlet extraction, to extract total flavonoids. On the basis of single factor test, the L9(34) orthogonal test was used in the optimization of technological parameters by investigating the ethanol concentration, extraction time and the material /solvent ratios. Using 0.1 mol·L−1 aluminum chloride (AlCl3) solution as chromogenic agent, the total flavonoids content was measured by ultraviolet and visible spectrophotometry. Results: The optimal extraction parameters showed that: ethanol concentration was 85%, ratio of solvent to raw material 40:1 and extraction time 1.5 h. The amount of total flavonoids in the leaf of Elaeagnus pungens Thunb. ...
Say I Love You With Flavonoid-Rich Foods for Valentines Day
The plant-based nutrient that will drive your special someone crazy this Valentines Day is great for fighting inflammation and can help prevent heart disease and cancer.. The good news is you can never get too much of it, either.. They are flavonoids, and these tiny good-for-you nutrients are found in many colorful foods, including a bottle of wine - and some dark chocolate. But a better choice may be a big batch of berries - you can always dip them in a cacao-rich chocolate, right?. Flavonoids are known powerful antioxidants that fight inflammation and can prevent plaque from building up in our blood vessels, said Avera Heart Hospital nutrition specialist Carri Oetken, RD, LN. They are found in many foods - they provide color to many plants. They work by preventing oxidative damage to cells, which could trigger chronic conditions such as cardiovascular disease and cancer. Fresh berries are some of the best sources.. Oxidative damage, or stress, can be caused by free radical, a form of ...
Flavonoids, Inflammation and Cancer - Hollie Swanson - Google Books
This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring constituents of plants that have been traditionally used as anti-inflammatory and anti-cancer medicines. In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased cancer mortalities rates.Flavonoids, Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation and the development of GI and steroid-responsive cancers. In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed.This book is an invaluable reference for basic and clinical scientists who are interested in exploring the link between nutrition and cancer.
IJMS | Free Full-Text | Chemical Reaction of Soybean Flavonoids with DNA: A Computational Study Using the Implicit Solvent Model
Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms of each of these flavonoids, diol epoxide form and diketone form. Density functional theory (DFT) and Hartree-Fock (HF) methods were used to study the reaction thermodynamics between active forms of flavonoids and DNA guanine. Solvent reaction field method of Tomasi and co-workers and the Langevin dipoles method of Florian and Warshel were used to calculate the hydration free energies. Activation free energy for each reaction was estimated using the linear free energy relation. Our calculations show that diol epoxide forms of flavonoids are more reactive than the corresponding diketone forms and are hence more likely flavonoid ultimate carcinogens. Genistein, daidzein and glycitein show
Flavonoids and metabolic syndrome<...
TY - JOUR. T1 - Flavonoids and metabolic syndrome. AU - Galleano, Monica. AU - Calabro, Valeria. AU - Prince, Paula D.. AU - Litterio, María C.. AU - Piotrkowski, Barbara. AU - Vazquez-Prieto, Marcela A.. AU - Miatello, Roberto M.. AU - Oteiza, Patricia I.. AU - Fraga, Cesar G.. PY - 2012/7. Y1 - 2012/7. N2 - Increasing evidence indicates that several mechanisms, associated or not with antioxidant actions, are involved in the effects of flavonoids on health. Flavonoid-rich beverages, foods, and extracts, as well as pure flavonoids are studied for the prevention and/or amelioration of metabolic syndrome (MS) and MS-associated diseases. We summarize evidence linking flavonoid consumption with the risk factors defining MS: obesity, hypertriglyceridemia, hypercholesterolemia, hypertension, and insulin resistance. Nevertheless, a number of molecular mechanisms have been identified; the effects of flavonoids modifying major endpoints of MS are still inconclusive. These difficulties are explained by ...
Flavonoid-Rich Foods May Lower Erectile Dysfunction Risk - ΑΛΕΞΑΝΔΡΟΣ ΖΗΣΟΠΟΥΛΟΣ - ΟΥΡΟΛΟΓΟΣ
During 10 years of follow-up, ED developed in 35.6% of subjects, according to results published online in the American Journal of Clinical Nutrition. After adjusting for cardiovascular and other factors (such as caffeine and alcohol consumption, body mass index, smoking, and physical activity), the investigators discovered that specific classes of flavonoids were associated with reduced incidence of ED: flavones (-9%), flavanones (-11%), and anthocyanins (-9 ...
Dietary flavonoid fisetin induces a forced exit from mitosis by targeting the mitotic spindle checkpoint.
Fisetin is a natural flavonol present in edible vegetables, fruits and wine at 2-160 microg/g concentrations and an ingredient in nutritional supplements with much higher concentrations. The compound has been reported to exert anticarcinogenic effects as well as antioxidant and anti-inflammatory activity via its ability to act as an inhibitor of cell proliferation and free radical scavenger, respectively. Our cell-based high-throughput screen for small molecules that override chemically induced mitotic arrest identified fisetin as an antimitotic compound. Fisetin rapidly compromised microtubule drug-induced mitotic block in a proteasome-dependent manner in several human cell lines. Moreover, in unperturbed human cancer cells fisetin caused premature initiation of chromosome segregation and exit from mitosis without normal cytokinesis. To understand the molecular mechanism behind these mitotic errors, we analyzed the consequences of fisetin treatment on the localization and phoshorylation of ...
quercetin Archives - ciggyfree.com
Flavonoids are plant-derived compounds that are capable of scavenging free radicals in the body.. Studies have shown that flavonoids have anticancer properties, but most of these trials have used amounts of flavonoids much higher than those typically found in the diet.. The new study, published in the journal Cancer, aimed to determine if flavonoids could protect against lung cancer in smokers and nonsmokers, by comparing the amount and types of flavonoids eaten by 558 people with lung cancer and 837 healthy people.. Smokers who ate more of certain flavonoids called catechin, epicatechin, quercetin, and kaempferol, as well as more vegetables, tea, and wine were less likely to develop lung cancer than smokers who ate less of these flavonoids and foods.. Surprisingly, the protective effect of these foods and flavonoids was not seen among nonsmokers. These results may reflect the finding that these flavonoid compounds are strong antioxidants against free radicals generated by tobacco smoking, ...
Antimicrobial properties of flavonoids. | IRIS Università di Pisa
Flavonoids are a class of plant constituents that have received increasing interest over the last decades. This chapter deals with the antimicrobial activity of some natural flavonoids or extracts rich in these constituents reported in the literature during the last five years. An introduction explains the chemical structure of this class of natural compounds, their biosynthesis, plant sources and health benefits. Then the most significant articles from the scientific literature are reported, divided into two sections: studies on flavonoids with antibacterial and antifungal activities, respectively. In each paragraph we have listed the papers according to the chemical complexity of the flavonoid structures, from the simplest to the most complex ones, both aglicones and glycosides and often gathering together the articles according to the main microbial target. A paragraph on the antimicrobial activity of combination of different flavonoids or between flavonoids and antibiotics (synergic effect) ...
What Are Flavonoids? | NaturesNaturalHealth.com
Antioxidants are wonderful things. They slow down the rate in which we age, and they help us look and feel younger than we actually are. Antioxidants are nutrients that are found in many of the foods we eat. They help to protect the body from the harmful effects of free radicals. Free radicals are molecules that cause cell damage and can cause illnesses such as cancer, heart disease, Alzheimers, and asthma. There are several types of antioxidants that can be distributed into two categories. They are the flavonoids and the nonflavonoids. This article will take a look at flavonoids.. Flavonoids are hundreds of thousands of various substances that are found in plants. These substances are what give the pigmentation to the plants. Plants that are red, yellow, orange all get their pigmentation from flavonoids. Hungarian scientist Albert Szent-Gyorgyi discovered these flavonoids in 1938, and called them vitamin P. The chemistry of the flavonoid is very complex and are separated into many groups. ...
Select Flavonoids Protect RPE Cells from Oxidative Stress
Dietary Flavonoids Afford Cellular Protection. It is increasingly clear that new approaches to treating AMD should focus on both preventing the initial insults that lead to disease progression, and rescuing the retinal pigment epithelium (RPE) and photoreceptor cells that have been damaged. Mounting evidence suggests that chronic oxidative stress may damage the retinal-RPE and predispose it to developing age-related macular degeneration (AMD).. Flavonoids are a large class of polyphenolic compounds found in fruits, vegetables, teas and wine that have evolved to protect plants from the oxidative damage caused by chronic UV exposure. Flavonoids are potent antioxidants that can also influence many cellular enzyme functions. They directly neutralize reactive oxygen species (ROS), and they modulate cell-signaling pathways. In particular they can induce expression of phase-2 proteins that enhance the cells natural defenses against oxidative stress.. Large-scale observational studies have linked ...
Flavonoids - The Big Book of Terps
This post features GIFs of the Top 10 Flavonoids in Cannabis, showing the entire rotating molecule of each. This ranking of the top 10 flavonoids in cannabis is based on laboratory tests of various strains, and is arranged by concentration from primary to secondary flavonoid constituents. These include flavonoids found in many plants around the world, as well as three flavonoids - the cannflavins - that to date have only been found in cannabis. Continue reading GIFs - Top Ten Flavonoids in Cannabis (Molecules). ...
Dietary flavonoid intakes and risk of type 2 diabetes in US men and women - Fingerprint - Queens University Belfast
Fingerprint Dive into the research topics of Dietary flavonoid intakes and risk of type 2 diabetes in US men and women. Together they form a unique fingerprint. ...
Flavonoids, immunity and cancer: from in vitro experiments to clinical trials - Eesti Arst - Eesti Arstide Liidu ajakiri
Numerous experimental studies of flavonoids as plant secondary metabolites have revealed their various benefits to human health. These polyphenolic compounds are able to prevent initiation and development of cancer through acting on several molecular targets and influencing different signalling pathways, including those involved in modulation of immune response and inflammatory reactions. This review article gives a survey about flavonoids, their structural and functional diversities and major immunomodulatory activities, but brings forth also the bottlenecks in translating preclinical effects to cancer prevention or therapy in humans. It can be expected that growing interest among general public in the use of flavonoids and food products rich in flavonoids, accompanying with ongoing efforts of scientific community to overcome the current barriers in application of these promising compounds, will further proovide new opportunities for cancer prevention, as well as will expand our current drug ...
09.19.00 - Beware of plant supplements called flavonoids; they could make you sick, warn UC Berkeley public health experts
Berkeley - Fruits and vegetables keep you healthy, but some of their chemical components, concentrated and sold in high doses as flavonoid supplements in health food stores, are likely to make you sick, warn scientists at the University of California, Berkeleys School of Public Health. The warning applies to such popular products as ginkgo pills, quercetin tablets, grape seed extract and flaxseed, which contain high concentrations of flavonoids. Unlike vitamins C and E, flavonoids become dangerous at the high doses available in some supplements, which are not regulated by any governmental agency, according to Martyn Smith, UC Berkeley professor of toxicology. Although they may protect against some forms of cancer when consumed in the diet, plant flavonoids actually have the capacity to become carcinogenic at higher levels, said Smith. High doses of these chemicals also carry other health risks including a small but documented risk for a rare form of leukemia in young children. I think some ...
Potential of the bioflavonoids in the prevention/treatment of ocular disorders - Majumdar - 2010 - Journal of Pharmacy and...
Objectives Flavonoids are a common group of plant polyphenols that give colour and flavour to fruits and vegetables. In recent years, flavonoids have gained importance in the pharmaceutical field through their beneficial effects on human health and are widely available as nutritional supplements. Several pharmacological actions of the bioflavonoids may be useful in the prevention or treatment of ocular diseases responsible for vision loss such as diabetic retinopathy, macular degeneration and cataract. This review aims to summarize the potential therapeutic applications of various bioflavonoids in different ocular diseases and also discusses delivery of these agents to the ocular tissues.. Key findings It is apparent that the flavonoids are capable of acting on various mechanisms or aetiological factors responsible for the development of different sight threatening ocular diseases. From a drug delivery perspective, ocular bioavailability depends on the physicochemical and biopharmaceutical ...
Vitamin D and flavonoids examined for impact on breast and ovari...( n indoor occupations or shift work die...)
n indoor occupations or shift work dietary supplements and vitamin D ...High intakes of calcium which could occur with intake of Vitamin D su... Dietary Flavonoid Intake and Breast Cancer Risk among Women in t...Flavonoids a class of antioxidants found in plants is associated wit...Brian Fink Susan Steck and Marilie Gammon of the University of North ...,Vitamin,D,and,flavonoids,examined,for,impact,on,breast,and,ovarian,cancers,biological,biology news articles,biology news today,latest biology news,current biology news,biology newsletters
Effects of flavonoids on the vascular endothelium: What is known and what is next?<...
TY - CHAP. T1 - Effects of flavonoids on the vascular endothelium: What is known and what is next?. AU - Weseler, A.R.. AU - Bast, A.. PY - 2012/1/1. Y1 - 2012/1/1. M3 - Chapter. SP - 309. EP - 330. BT - Flavonoids and related compounds. Bioavailability and function.. A2 - Spencer, J.P.E.. A2 - Crozier, A.. PB - CRC Press. ER - ...
Fabulous Flavonoids - Dale Pinnock
Any of you that follow my work will know that I am just a wee bit obsessed with phytochemicals. These are chemicals in plants that arent nutrients as such, in that they arent essential to life and we can get deficiencies of them, but they can interact with our physiology. They have been the basis of a big chunk of my work over the years.. One phytochemical group in particular that you will often hear me talking about are the flavonoids. These are one of the largest phytochemical groups. They are secondary metabolites that give very rich colour pigments in foods from deep dark purples to vivid reds.. Benefits of flavonoids:. Antioxidant. Flavonoids have a long standing reputation as being effective antioxidants, particularly those of the flavanol and the flavan-3-ol varieties. Exactly how flavonoids deliver their antioxidant activity is still unclear, but there are certain types of cell in the body that they seem to have an affinity for in terms of protection against free radical damage. Red ...
Flavonoids associated with better erectile function - Harvard Health
Flavonoid-rich foods like berries, cherries, grapes, apples, pears, and citrus fruit may lower risk of erectile dysfunction. Researchers believe flavonoids…
This article provides an overview of current research on flavonoids as presented during a workshop entitled, Flavonoids and Heart Health, held by the ILSI North America Project Committee on Flavonoids in Washington, DC, May 31 and June 1, 2005. Because a thorough knowledge and understanding about the science of flavonoids and their effects on health will aid in establishing dietary recommendations for bioactive components such as flavonoids, a systematic review of the science of select flavonoid classes (i.e., flavonols, flavones, flavanones, isoflavones, flavan-3-ols, anthocyanins, and proanthocyanidins) was presented. The objectives of the workshop were to 1) present and discuss current research on flavonoid intake and the relation between flavonoids and heart health; 2) develop information that could lead to expert consensus on the state-of-the-science of dietary intake of flavonoids on heart health; and 3) summarize and prioritize the research needed to establish the relations between ...
Flavonoid Intake is Associated with Lower Incidence of Depression In Women - Larsen Global
Flavonoids are phytonutrients (plant nutrients) found in tea, chocolate, red wine and many fruits and vegetables. They are already known to offer protective cardiovascular health effects and other health benefits, however the effect of flavonoid intake on depression has been unclear up to this point. Researchers from Harvard published an article in the American Journal of Clinical Nutrition analyzing data from the Nurses Health Study and the Nurses Health Study II, looking at potential links between flavonoid intake and depression.. The Nurses Health Study and Nurses Health Study II included 82,643 women without a previous history of depression. Over a period of 10 years of follow-up, a total of 10,752 incidents of depression were found. Analysis of flavonoid intake and depression frequency revealed that the highest quintile of total flavonoid, polymer, and proanthocyanidin intake was associated with a 9-12% decreased risk of depression. Lower intakes were associated with a reverse linear, ...
Study: Eat Apples and Drink Tea to Live Longer
Consuming flavonoid-rich items such as apples and tea protects against cancer and heart disease, particularly for smokers and heavy drinkers, according to new research from Edith Cowan University (ECU).. Researchers from ECUs School of Medical and Health Sciences analyzed data from the Danish Diet, Cancer and Health cohort that assessed the diets of 53,048 Danes over 23 years.. They found that people who habitually consumed moderate to high amounts of foods rich in flavonoids, compounds found in plant-based foods and drinks, were less likely to die from cancer or heart disease.. No quick fix for poor habits. Lead researcher Dr. Nicola Bondonno said while the study found a lower risk of death in those who ate flavonoid-rich foods, the protective effect appeared to be strongest for those at high risk of chronic diseases due to cigarette smoking and those who drank more than two standard alcoholic drinks a day.. These findings are important as they highlight the potential to prevent cancer and ...
Ask an Expert: testing for flavonoids in tea with milk. oh dear, help. - Page 3
It is suggested that the overall antioxidant effect of flavonoids on lipid peroxidation may be related to their OH and O2 scavenging properties and their reaction with peroxy radicals. Thus, O2 may play an important role during the perodixation of unsaturated fatty acids and possibly other susceptible substances. Therefore, the study of the scavenging effects of antioxidants on O2 is one of the most important ways of making clear the mechanism of antioxidant activity and has therefore caused growing interest among researchers. Flavonoids can be used directly to scavenge O2 and OH by single electron transfer. The scavenging process can generally be followed by means of electron spin resonance... The photochemical reduction of riboflavin was first used to determine the dismutation of O2 by superoxide dismutase (SOD) and has been adapted for analysis of the dismutation of O2 by a model compound of superoxide dismutase and other natural compounds ...
Flavonoids as DNA topoisomerase antagonists and poisons: Structure-activity relationships<...
TY - JOUR. T1 - Flavonoids as DNA topoisomerase antagonists and poisons. T2 - Structure-activity relationships. AU - Constantinou, Andreas. AU - Mehta, Rajendra. AU - Runyan, Constance. AU - Rao, Kandala. AU - Vaughan, Andrew T M. AU - Moon, Richard. PY - 1995. Y1 - 1995. N2 - Selected flavonoids were tested for their ability to inhibit the catalytic activity of DNA topoisomerase (topo) I and II. Myricetin, quercetin, fisetin, and morin were found to inhibit both enzymes, while phloretin, kaempferol, and 4′,6,7-trihydroxyisoflavone inhibited topo II without inhibiting topo I. Flavonoids demonstrating potent topo I and II inhibition required hydroxyl group substitution at the C-3, C-7, C-3′, and C-4′ positions and also required a keto group at C-4. Additional B-ring hydroxylation enhanced flavonoid topo I inhibitory action. A C-2,C-3 double bond was also required, but when the A ring is opened, the requirement for the double bond was eliminated. Genistein has been previously reported to ...
Episode 12 - Phytochemicals as anti-cancer compounds. How Resveratrol, Berberine, Curcumin and the dietary Flavonoids can be...
This is the home of the science on the edge podcast series. We aim to discuss all things cutting edge from genetic engineering, to stem cell research, to neuroscience and consciousness - and everything inbetween. ...
What Are Flavonoids?
A crucial piece of the puzzle: flavonoids Compounds that form a crucial piece of the CBD puzzle are flavonoids. However, it isnt just the hemp plant that has made these colourful phytonutrients popular. Over 6,000 flavonoids exist in virtually all fruits, vegetables, and herbs. Red peppers, blueberries, oranges-all of these foods owe their vibrant colouring to flavonoids. Every colour represents a different flavonoid-natures answer to repelling pests, protecting plants, and signalling cellular
ZAFRANzafrina: 12 PRODUK TERBAIK SHAKLEE YANG MENJADI PILIHAN PESAKIT KANSER
7.Flavomax- this is a powerful antioxidant product which will fight free radicals. It contains six key classes of flavonoids: proanthocyanidins, anthocyan-idins, flavan-3-ols, flavones, flavonols, and flavanones. Shaklee uses standardized extracts of each of these flavonoids to ensure potency and quality. Flavonoids are potent, water-soluble antioxidants that have been linked to healthy blood circulation, strong capillaries, and veins. Flavonoids also deliver anti-oxidant protection to blood and blood-rich tissues, such as the liver and the intestines. Unfortunately, few diets provide these important phytonutrients in significant quantities, since flavonoids are often found in seeds, rinds, and skins, parts of fruits and vegetables that are likely to be tossed away during food preparation. Many people dislike eating the skins of fruits and vegetables. ...
Eating Flavonoids Protects Men Against Parkinsons Disease, Study Finds | Nutrition Review
Men who eat flavonoid-rich foods such as berries, tea, apples and red wine significantly reduce their risk of developing Parkinsons disease, according to new
Fisetin: The Antioxidant Your Bones Cant Do Without - Save Our Bones
1 Higa, S., et al. Fisetin, a flavonol, inhibits TH2-type cytokine production by activated human basophils. J Allergy Clin Immunol. June 2003. 111(6):1299-306. Web. http://www.ncbi.nlm.nih.gov/pubmed/12789233. 2 Sengupta B, Banerjee A, Sengupta PK. Interactions of the plant flavonoid fisetin with macromolecular targets: insights from fluorescence spectroscopic studies. J Photochem Photobiol B. August 2005. 80(2):79-86. Web. http://www.ncbi.nlm.nih.gov/pubmed/16038806. 3 Maher, P. Modulation of multiple pathways involved in the maintenance of neuronal function during aging by fisetin. Genes Nutr. 2009 Sep 10.. 4 De Santi, C., et al. Sulphation of resveratrol, a natural compound present in wine, and its inhibition by natural flavonoids. Xenobiotica. 2000 Sep;30(9):857-66.. 5 Currais, A., et al. Modulation of p25 and inflammatory pathways by fisetin maintains cognitive function in Alzheimers disease transgenic mice. Aging Cell. April 2014. 13(2):379-90. Doi: 10.1111/acel.12185. Web. ...
Low flavonoid intake associated with Alzheimers risk
A new study finds that a low intake of flavonoid-rich foods, such as berries, apples, and tea, is associated with a higher risk of Alzheimers disease.
Flavonoids: Antioxidants Help the Mind | Psychology Today
Naturally occurring plant pigments, flavonoids are one of the reasons fruits and vegetables are so good for you. Among the many benefits attributed to flavonoids are reduced risk of cancer, heart disease, asthma, and stroke.
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About The Buzz: Dietary Flavonoids Prevent Weight Gain? - Have A Plant
A newly published study, which followed participants for up to 24 years, included 124,000 men and women and began in 1986. In total, over 124,000 people between the ages of 27-65 participated. All study participants self-reported their diet every four (4) years using a food frequency questionnaire. Their flavonoid intake was calculated by how frequently they consumed flavonoid-containing foods. Participants also reported on their lifestyle habits and weight every two (2) years. They were also asked to report any changes in smoking status, physical activity level, hours spent sitting or watching TV, and hours of sleep.. Over each four-year period, men gained 2.2lbs on average and women gained 2.9lbs. Intake of flavonoids was an average of 224 milligrams per day in men and 247 milligrams per day in women. Every additional 10 milligrams of daily intake was associated with 0.16 to 0.23 lbs. less weight gained over four-year periods. A quarter cup of strawberries or cherries contains about 10 mg of ...
Combined effect of flavonoid compounds and cytostatics in cancer treatment
Aim. The aim of the study was to review the literature on the combination of cytostatics with flavonoids as a promising way to improve the cancer therapy. Material and methods. A review of Polish and foreign literature was performed. The following databases were searched: PubMed, Scopus, Science Direct, and Polish Medical Bibliography. Literature analysis. Effective strategies to inhibit the progression of cancer are needed. Compounds of natural origin, including plant polyphenols, are a part of our diet. Due to their availability, and antioxidant properties, they may serve as efficacious adjuvants in cancer therapy, enhancing the effectiveness of chemotherapeutics. Epidemiological studies have shown an inverse relationship between diets rich in fruits, vegetables, and supplements, and the risk of all causes of death from cancer. Based on their diverse biological activity, flavonoids may be potential adjuvant therapeutic agents that act synergistically with cytostatics for treatment of many ...
Project : USDA ARS
This agreement was created to support the development of the Expanded USDA Flavonoid Databases for the Assessment of Dietary Intakes and a database for the estimation of the intake of 29 flavonoid components. The project is a collaborative effort between the Nutrient Data Laboratory (NDL) and the Food Surveys Research Group (FSRG). USDAs databases on the flavonoid content of selected foods were expanded to include full profiles for six subclasses (flavanols, flavan-3-ols, flavones, flavanones and anthocyanidins plus isoflavones) for ~2,900 food items included in Food and Nutrient Database for Dietary Studies (FNDDS) 4.1 and used in National Health and Nutrition Examination Survey (NHANES), What We Eat in America 2007-08. Analytical values were taken from Release 3.1 of the flavonoid database and Release 2.0 of the isoflavones database. Release 3.0 of the flavonoid database was updated during FY2012 to correct a few values and add some additional food items to create Release 3.1, which was ...
Flavonoids sources, health benefits and uses
Flavonoids are water-soluble polyphenolic molecules that have 15 carbon atoms. They appear as two benzene rings that are connected together ...
Flavonoids | Fundación CANNA: Scientific studies and cannabis testing
Flavonoids are secondary polyphenolic metabolites that commonly have a ketone group and yellowish pigments, after which they are named (from the Latin flavus,
Are flavonoids the new superfood? - NZ Herald
Flavonoids are all over the news at the moment, boasting how you can slim down by only eating a few grapes and how
In silico metabolism studies of dietary flavonoids by CYP1A2 and CYP2C9
A free platform for explaining your research in plain language, and managing how you communicate around it - so you can understand how best to increase its impact.
Flavonoids May Help With Weight Loss | Science Trends
British researchers believe that certain plant substances can influence the amount of body fat. There is this simple rule: If you consume fewer calories than
flavonoids - Brain Tree Fruit
This is not the first time I have drawn attention to research that substantiates the importance of flavonoids / polyphenols to your daily diet. This time. ...
Flavonoids - Antioxidant Guru
The news mostly the cancers are related with the diet disorders and the researches had exposed this fact that, as AICR, US says, 30-40% of cancer cases are found due to diet and over weight. But many food items are supposed to carry the risk reducing elements as flavonoids etc. that are found in a variety of foods from plants. It is for this reason, the scientists and medical professionals are stressing on plant foods more than other types of foods. Plants food like fruits and vegetables … [Read more...]. ...
Chemometric characterisation of some flavonoids active against HT-29 human cancer cells | IEEE Conference Publication | IEEE...
Flavonoids contribute to the prevention of various diseases related to oxidative stress, including cancer, due to their antioxidative properties. The database b
Thorne Research- Vitamin C with Flavonoids 180 caps - Premier Formulas
Buy Thorne Research- Vitamin C with Flavonoids 180 caps Online. Guaranteed Fast Shipping & Personal Customer Service From Premier Formulas.
Phenolic content in wine
... flavonoids and non-flavonoids. Flavonoids include the anthocyanins and tannins which contribute to the color and mouthfeel of ... The non-flavonoids include the stilbenoids such as resveratrol and phenolic acids such as benzoic, caffeic and cinnamic acids. ... Like other flavonoids, the concentration of flavonols in the grape berries increases as they are exposed to sunlight. Some ... June 2001). "Flavonoids act as negative regulators of auxin transport in vivo in arabidopsis". Plant Physiol. 126 (2): 524-35. ...
Phenolic content in tea
Phenols called flavonoids are under preliminary research, as of 2020, but there is no evidence that flavonoids affect physical ... According to a report released by USDA, in a 200-ml cup of tea, the mean total content of flavonoids is 266.68 mg for green tea ... Tea has one of the highest contents of flavonoids among common food and beverage products. Catechins are the largest type of ... "Flavonoids". Linus Pauling Institute, Oregon State University, Corvallis. 2016. Retrieved 2020-04-15. EFSA Panel on Dietetic ...
"Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. November 2015. ...
"Flavonoids". Micronutrient Information Center. Linus Pauling Institute, Oregon State University, Corvallis. 2016. Retrieved 24 ...
"Flavonoids". Linus Pauling Institute. 28 April 2014. "Hinokitiol , 499-44-5". www.chemicalbook.com. Bentley, Ronald (2008). "A ...
"Flavonoids". Micronutrient Information Center. Linus Pauling Institute, Oregon State University, Corvallis. 2016. Retrieved 2 ... together with other flavonoids localized mainly in berry skins, seeds and leaves. Although berry pigments have antioxidant ...
"Flavonoids". Linus Pauling Institute, Oregon State University, Corvallis. 2016. Retrieved 24 July 2016. Lemmo W (September 2014 ... Beecher GR (October 2003). "Overview of dietary flavonoids: nomenclature, occurrence and intake". The Journal of Nutrition. 133 ...
"Flavonoids". Linus Pauling Institute, Micronutrient Information Center, Oregon State University. 2015. Retrieved 8 June 2015. ...
ATP citrate synthase
... malonylated flavonoids, acylated, prenylated and malonated proteins). De novo fatty acid biosynthesis in plants occurs in ... flavonoids; malonic acid; acetylated phenolics, alkaloids, isoprenoids, anthocyanins, and sugars; and, mevalonate-derived ...
... (from Latin flavus "yellow") are a class of flavonoids based on the backbone of 2-phenylchromen-4-one (2-phenyl-1- ... "Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, OR. November 2015. ... David Stauth (5 March 2007). "Studies force new view on biology of flavonoids". EurekAlert!; Adapted from a news release issued ... Harborne, Jeffrey B.; Marby, Helga; Marby, T. J. (1975). The Flavonoids - Springer. doi:10.1007/978-1-4899-2909-9. ISBN 978-0- ...
... flavonoids from citrus (ID 1471); flavonoids from Citrus paradisi Macfad. (ID 3324, 3325); flavonoids (ID". EFSA Journal. 9 (4 ... flavonoids, stilbenes, and lignans". Flavonoids include flavones, flavonols, flavanols, flavanones, isoflavones, ... Polyphenols include flavonoids, tannic acid, and ellagitannin, some of which have been used historically as dyes and for ... Flavonoid configurations can also cause significant differences in sensory properties, e.g. epicatechin is more bitter and ...
Various citrus fruit peels contain 32 to 49 mg/g of flavonoids expressed as rutin equivalents. Citrus leaves contain rutin at ... Rutin is a citrus flavonoid glycoside found in many plants including buckwheat, the leaves and petioles of Rheum species, and ... "Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, Oregon. November ... It is a citrus flavonoid found in a wide variety of plants including citrus. Rutin is one of the phenolic compounds found in ...
... flavonoids, and stilbenes/lignans. Flavonoids can be further divided into groups based on their similar chemical structure, ... Others, such as some polyphenols and flavonoids, may be pro-oxidants in high ingested amounts. Non-digestible dietary fibers ... "Flavonoids". Micronutrient Information Center, Linus Pauling Institute, Oregon State University, Corvallis, Oregon. November ...
As flavonoids, catechins can act as antioxidants when in high concentration in vitro, but compared with other flavonoids, their ... It belongs to the group of flavan-3-ols (or simply flavanols), part of the chemical family of flavonoids. The name of the ... Chun, O. K.; Chung, S. J.; Song, W. O. (2007). "Estimated dietary flavonoid intake and major food sources of U.S. Adults". The ... "Flavonoids". Linus Pauling Institute, Oregon State University, Corvallis. 2016. Retrieved 24 July 2016. Ottaviani, J. I.; Momma ...
The Systematic Identification of Flavonoids. Mabry et al, 1970, page 81 The compound in the Mediterranean diet that makes ... Forkmann, G. (January 1991). "Flavonoids as Flower Pigments: The Formation of the Natural Spectrum and its Extension by Genetic ... Apigenin is particularly abundant in the flowers of chamomile plants, constituting 68% of total flavonoids. Dried parsley can ... Delage, PhD, Barbara (November 2015). "Flavonoids". Linus Pauling Institute, Oregon State University, Corvallis, Oregon. ...
doi:10.1016/S0040-4039(01)96524-4. Potonay, T.; Batta, G.; Dinya, Z. (1988). "Flavonoids. 41. Stereospecific synthesis of 2,3- ...
The flavonoids are products from a cinnamoyl-CoA starter unit, with chain extension using three molecules of malonyl-CoA. ... Flavanols (with an "a") are not to be confused with flavonols (with an "o"), a class of flavonoids containing a ketone group. ... Winkel-Shirley, Brenda.Flavonoid Biosynthesis. A Colorful Model for Genetics, Biochemistry, Cell Biology, and Biotechnology. ... BBC News , Health , Chocolate 'has health benefits' Mabry, Helga; Harborne, J. B.; Mabry, T. J. (1975). The Flavonoids. London ...
Basics of blue flower colouration
Those enzymes are especially flavonoid 3'5'-hydroxylase (F3'5'H) and dihydroflavonol 4-reductase (DFR). The flavonoid 3'5'H- ... Blue colour in flower petals is caused by anthocyanins, which are members of flavonoid class metabolites. We can diversify ... Co-pigments usually are flavonoids (flavones, flavonols, flavanons, flavanols), other polyphenols, alkaloids, amino acids or ... The Flavonoids. doi:10.1007/978-1-4899-2913-6. ISBN 978-0-412-28770-1. S2CID 31877853.[page needed] Yoshida, Kumi; Mori, Mihoko ...
Justesen U, Knuthsen P (May 2001). "Composition of flavonoids in fresh herbs and calculation of flavonoid intake by use of ... Quercetin is a flavonoid widely distributed in nature. The name has been used since 1857, and is derived from quercetum (oak ... Compared to other flavonoids quercetin is one of the most effective inducers of the phase II detoxification enzymes. Quercetin ... Quercetin is the aglycone form of a number of other flavonoid glycosides, such as rutin and quercitrin, found in citrus fruit, ...
Porter, Lawrence J. (1988-01-01). "Flavans and proanthocyanidins". In Harborne, J. B. (ed.). The Flavonoids. Springer US. pp. ... blood from Dracaena draco and Dracaena cinnabari can be distinguished by differences in 10 compounds and a dominant flavonoid ...
The flavonoid has been demonstrated to have a hypoglycemic effect by increasing the ability of adipocytes, as well as cells of ... Antioxidants, including flavonoids such as myricetin, are often touted to reduce the risk of atherosclerosis, the hardening of ... Flavonoids including myricetin are able to scavenge for ROS and can chelate intracellular transition metal ions that ultimately ... It is also proposed that myricetin may have the ability as a potent flavonoid antioxidant to prevent LDL oxidation, thus ...
Nevertheless, flavonoids are in general thought to have beneficial effects for humans. Certain studies shown ... A number of in vitro and limited in vivo studies shown that flavonoids such as quercetin have synergistic activity with ... Resveratrol is a phenolic compound of the flavonoid class. It is highly abundant in grapes, blueberries, raspberries and ... Panche AN, Diwan AD, Chandra SR (2016-12-29). "Flavonoids: an overview". Journal of Nutritional Science. 5: e47. doi:10.1017/ ...
John Buckingham, V. Ranjit N. Munasinghe (2015). Dictionary of Flavonoids. CRC Press. ISBN 1-4822-8250-X. Sarah De Saeger (2011 ...
... flavonoid 3'-hydroxylase, and flavonoid 3',5'-hydroxylase, These oxidation products are further reduced by the enzyme ... flavonoid 3'-hydroxylase (F3′H), dihydroflavonol 4-reductase (DFR), anthocyanidin synthase (ANS), UDP-glucoside: flavonoid ... "Studies force new view on biology of flavonoids", by David Stauth, EurekAlert!. Adapted from a news release issued by Oregon ... Anthocyanin pigments are assembled like all other flavonoids from two different streams of chemical raw materials in the cell: ...
It also contains flavonoids. B. sempervirens wasn't known for its medical use until the beginning of the 1600s. After this it ... He also isolated a flavonoid glycoside, and named it galactobuxin based on the fact that it contains a galactose ring. Boxwood ...
Narra leaves contain flavonoids. Flavonoids are antioxidants that provide health benefits to humans, such as anti-inflammatory ... Flavonoids in narra leaves may be capable of preventing damage to your kidneys. In folk medicine, it is used to combat tumors. ...
Flavonoids from Licania pyrifolia". Pharmaceutica Acta Helvetiae. 71 (3): 199-204. doi:10.1016/0031-6865(96)00009-x. ISSN 0031- ... Like other members of its family, the genus is known for producing a diverse array of flavonoid compounds. Species include: ... Flavonoids and triterpenoids from Licania pittieri". Pharmaceutica Acta Helvetiae. 70 (3): 223-226. doi:10.1016/0031-6865(95) ... Flavonoids and triterpenoids from Licania carii". Pharmaceutica Acta Helvetiae. 71 (3): 191-197. doi:10.1016/0031-6865(96)00010 ...
Ahmad, V. U.; Z. Ali; S. R. Hussaini; F. Iqbal; M. Zahid; M. Abbas; N. Saba (1999-08-01). "Flavonoids of Tephrosia purpurea". ...
Flavonoids of Elaeocarpus lanceofolius. AB Ray, SC Dutta and S Dasgupta, Phytochemistry, Volume 15, Issue 11, 1976, pages 1797- ...
Sulfated flavonoids seem to also have an important role in co-pigmentation by forming stable complexes with anthocyanin ... The functional role played by persicarin in plant cells and tissues, and in fact the role of other sulfated flavonoids in ... Persicarin is a sulfated flavonoid naturally found in the cells of several plant species, including the water dropwort ( ... It has been theorised that sulfated flavonoids play a role in molecular recognition, stimulate plant hormone transport, ...
What are Flavonoids?
Flavonoids are a group of plant metabolites thought to provide health benefits through cell signalling pathways and antioxidant ... Some flavonoids also inhibit cellular uptake of vitamin C and some experts advise avoiding flavonoid-rich foods or drinks when ... Some flavonoids also inhibit certain spores to protect against certain plant diseases. Flavonoids are ubiquitous in plants and ... Flavonoids are also abundant in red wine, which some have theorized is the reason why the incidence of heart disease may be ...
Flavonoid - Wikipedia
Flavonoids are secondary metabolites synthesized mainly by plants. The general structure of flavonoids is a 15-carbon skeleton ... Flavonoids are widely distributed in plants, fulfilling many functions. Flavonoids are the most important plant pigments for ... Unit: mg/100g Food composition data for flavonoids were provided by the USDA database on flavonoids. In the United States ... Microbial metabolism is a major contributor to the overall metabolism of dietary flavonoids. The effect of habitual flavonoid ...
Flavonoid alkaloid - Wikipedia
The synthesis of flavonoid alkaloids has been achieved A number of flavonoid alkaloids have been discovered that possess ... A flavonoid alkaloid also known as a flavoalkaloid is a type of natural product produced by plants that contains both a ... The most common flavonoid alkaloids contain a nitrogen heterocycle such as a pyridine or piperidine which is covalently bonded ... Synthesis of novel flavonoid alkaloids as α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry. Jain SK, Bharate SB, ...
flavonoid (CHEBI:47916) is a flavonoids (CHEBI:72544). flavonoid oligomer (CHEBI:72720) is a flavonoids (CHEBI:72544). ... flavonoids (CHEBI:72544) is a organic molecular entity (CHEBI:50860) flavonoids (CHEBI:72544) is a oxygen molecular entity ( ... aurones (CHEBI:72576) is a flavonoids (CHEBI:72544). chalcones (CHEBI:23086) is a flavonoids (CHEBI:72544). coumestans (CHEBI: ... isoflavonoid (CHEBI:50753) is a flavonoids (CHEBI:72544). monoxerutin (CHEBI:134704) is a flavonoids (CHEBI:72544). N-(2- ...
Flavonoids of Artemisia transiliensis | SpringerLink
Flavonoids of Berteroa incana I | SpringerLink
Flavonoids and heart disease | The BMJ
Flavonoids, Inflammation and Cancer - Hollie Swanson - Google Books
This book provides an insightful analysis of the chemopreventive actions of flavonoids. Flavonoids are naturally occurring ... In addition, the promise and pitfalls associated with using flavonoids as chemopreventive agents are discussed.This book is an ... In addition, human consumption of vegetables and fruits with high concentrations of flavonoids is associated with decreased ... Inflammation and Cancer presents an in-depth analysis of the mechanisms by which flavonoids are thought to prevent inflammation ...
Fisetin | flavonoid | Britannica
Flavonoids: Antioxidants Help the Mind | Psychology Today
... flavonoids are one of the reasons fruits and vegetables are so good for you. Among the many benefits attributed to flavonoids ... Flavonoids: Antioxidants Help the Mind Naturally occurring plant pigments, flavonoids are one of the reasons. fruits and ... But flavonoids go beyond the yeoman work of your average antioxidant. Scientists have found that certain flavonoids have ... Fortunately, you dont have to eat brussels sprouts (they have a low flavonoid content) to get your flavonoid fix. Some potent ...
Are flavonoids the new superfood? - NZ Herald
Flavonoids are all over the news at the moment, boasting how you can slim down by only eating a few grapes and how Flavonoids are all over the news at the moment, boasting how you can slim down by only eating a few grapes and how some fruit ... Flavonoids - why fresher is better. Ever wondered why that fruit or veg youve left hanging around in the back of the fruit ... Because flavonoids provide the colour in many foods, to get the best dose you should seek out those fruit and vegetables with ...
Know Your Flavonoids | Newsmax.com
There are approximately 4,000 different flavonoid compounds found in foods, but not all vegetables or fruits contain the same ... But not all vegetables or fruits contain the same flavonoids. Here is a list of beneficial flavonoids and the foods they are ... But not all vegetables or fruits contain the same flavonoids. Here is a list of beneficial flavonoids... ... There are approximately 4,000 different flavonoid compounds found in foods, many of which have antioxidant, anti-inflammatory, ...
Eating Flavonoids Protects Men Against Parkinson's Disease - Redorbit
Men who eat flavonoid-rich foods such as berries, tea, apples and red wine significantly reduce their risk of developing ... Flavonoids are a group of naturally occurring, bioactive compounds found in many plant-based foods and drinks. In this study ... No similar link was found for total flavonoid intake in women.. The research was led by Dr Xiang Gao of Harvard School of ... "This is the first study in humans to look at the associations between the range of flavonoids in the diet and the risk of ...
book wanted] Geissman's flavonoids
Cytotoxic Activities of Flavonoids from Centaurea scoparia
... Sayed A. Ahmed and Emadeldin M. Kamel ... W. Huang, P. Chien, C. Yang, and A. Lee, "Novel synthesis of flavonoids of Scutellaria baicalensis Georgi," Chemical and ... P. K. Agrawal and R. P. Rastogi, "13C NMR spectroscopy of flavonoids," Heterocycles, vol. 16, no. 12, pp. 2181-2236, 1981. View ... G. Flamini, E. Antognoli, and I. Morelli, "Two flavonoids and other compounds from the aerial parts of Centaurea bracteata from ...
China flavonoids ginkgo biloba extracts wholesale 🇨🇳 - Alibaba
China Flavonoids Ginkgo Biloba Extracts Suppliers and Manufacturers Directory - Source a Large Selection of Flavonoids Ginkgo ... Tags: Flavonoids Ginkgo Biloba Extracts , Pure Flavonoids Ginkgo Biloba Extracts , Natural Flavonoids Ginkgo Biloba Extracts ... The top supplying country is China (Mainland), which supply 100% of flavonoids ginkgo biloba extracts respectively. Flavonoids ... Pure Natural Ginkgo Biloba Extract/Ginkgo Biloba Leaf Extract/100% Natural Flavonoids ginkgo biloba extract ...
Nutrients | Free Full-Text | Flavonoids and Asthma
Flavonoids are powerful antioxidants and anti-allergic nutrients that inhibit the release of chemical mediators, synthesis of ... Various studies of flavonoids in asthmatic animal models have demonstrated their beneficial effects. The results of several ... Flavonoids, which are polyphenolic plant secondary metabolites ubiquitously present in vegetables, fruits and beverages, ... Moreover, clinical trials of flavonoids have shown their ameliorative effects on symptoms related to asthma. However, these ...
Flavonoids from Pterogyne nitens Inhibit Hepatitis C Virus Entry | Scientific Reports
Flavonoids 1 and 2 inhibited virus entry up to 45.0% and 78.7% respectively at non-cytotoxic concentrations. The mechanism of ... Alternatively, the flavonoid 1 activity was restricted to its virucidal effect. Additionally, no inhibitory effects on HCV ... This study aimed to evaluate the antiviral effects of sorbifolin (1) and pedalitin (2), two flavonoids from Pterogyne nitens on ... the flavonoid 2 block to virus entry was demonstrated to be by both the direct action on virus particles and the interference ...
Polyphenols Vs. Flavonoids | Livestrong.com
However, although all flavonoids are polyphenols, polyphenols not necessarily are flavonoids. Plants produce flavonoids as a ... Classification of Flavonoids. Flavonoids are the largest family of polyphenolic compounds; that is why the words "polyphenols" ... Food Sources of Flavonoids. Anthocyanins are pigments that give plants purple and blue colors. Examples of foods rich in ... All polyphenols, including flavonoids, offer numerous health benefits. Besides being potent antioxidants, some polyphenols have ...
flavonoids Archives - Nova Science Publishers
Nova publishes a wide array of books and journals from authors around the globe, focusing on Medicine and Health, Science and Technology and the Social Sciences and Humanities.. We publish over 1,500 new titles per year by leading researchers each year, and have a network of expert authors, editors and advisors spanning the global academic community in pursuit of advanced research developments.. We invite you to browse our site to find the books or journals of particular interest to you.. Headquarters ...
Differential Induction of Flavonoids in Groundnut in Response to Heli… - English
Flavonoids are important plant secondary metabolites, which protect plants from various stresses, including herbivory. Plants ... Sharma and Norris3 observed the negative effect of flavonoids from soybean on Trichoplusia ni (Hub.). Flavonoid production has ... tant and abundant group of plant defensive compounds involved in defense against herbivory.1-5 Flavonoids and iso- flavonoids ... Effect of fla- vonoids on feeding preference and development of the crucifer pest Mamestra configurata Walker. J Chem Ecol. ...
Genetics and biochemistry of seed flavonoids. - PubMed - NCBI
Genetics and biochemistry of seed flavonoids.. Lepiniec L1, Debeaujon I, Routaboul JM, Baudry A, Pourcel L, Nesi N, Caboche M. ... Flavonoids are secondary metabolites that accumulate in most plant seeds and are involved in physiological functions such as ... In addition, flavonoids provide an interesting model to study various biological processes and metabolic and regulatory ... This review presents a current view of the genetic and biochemical control of flavonoid metabolism during seed development. It ...
Low flavonoid intake associated with Alzheimer's risk
A new study finds that a low intake of flavonoid-rich foods, such as berries, apples, and tea, is associated with a higher risk ... 6 types of flavonoid. The study looked at the intake of six different types of flavonoid among 2,801 people and took place over ... Low flavonoid intake associated with Alzheimers risk. Written by Eleanor Bird, M.S. on May 18, 2020 - Fact checked by. Shikta ... A new study links a low intake of flavonoid-rich foods - such as berries, apples, and tea - with a higher risk of Alzheimers ...
Flavonoids. V. Thiation of Isoflavones | RTI
Anthocyanins and other flavonoids
More than 450 new flavonoid structures, reported from January 2001 until December 2003, are reviewed. They comprise ... Anthocyanins and other flavonoids Nat Prod Rep. 2004 Aug;21(4):539-73. doi: 10.1039/b311404j. Epub 2004 Jul 7. ... More than 450 new flavonoid structures, reported from January 2001 until December 2003, are reviewed. They comprise ...
11/01/13 Pecs, Hungary - WG2 Review Flavonoids | University College Cork
Foods High in Flavonoids May Help With Erectile Dysfunction
Research has demonstrated that men younger than 70 who regularly eat foods with flavonoids will have an 11 to 16 percent ... Research has demonstrated that men younger than 70 who regularly eat foods with flavonoids will have an 11 to 16 percent ... More Benefits of Flavonoids. The benefits of eating a healthy diet, full of flavonoid rich fruits, vegetables and tea, go ... Foods With Flavonoids. Not all fruits and vegetables are created equally. Those that have higher amounts of flavonoids, and ...