Fibrosis. Medical search

Any pathological condition where fibrous connective tissue invades any organ, usually as a consequence of inflammation or other injury.

An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)

A condition characterized by the thickening of the ventricular ENDOCARDIUM and subendocardium (MYOCARDIUM), seen mostly in children and young adults in the TROPICAL CLIMATE. The fibrous tissue extends from the apex toward and often involves the HEART VALVES causing restrictive blood flow into the respective ventricles (CARDIOMYOPATHY, RESTRICTIVE).

A common interstitial lung disease of unknown etiology, usually occurring between 50-70 years of age. Clinically, it is characterized by an insidious onset of breathlessness with exertion and a nonproductive cough, leading to progressive DYSPNEA. Pathological features show scant interstitial inflammation, patchy collagen fibrosis, prominent fibroblast proliferation foci, and microscopic honeycomb change.

Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.

A slowly progressive condition of unknown etiology, characterized by deposition of fibrous tissue in the retroperitoneal space compressing the ureters, great vessels, bile duct, and other structures. When associated with abdominal aortic aneurysm, it may be called chronic periaortitis or inflammatory perianeurysmal fibrosis.

A complex of related glycopeptide antibiotics from Streptomyces verticillus consisting of bleomycin A2 and B2. It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors.

Experimentally induced chronic injuries to the parenchymal cells in the liver to achieve a model for LIVER CIRRHOSIS.

Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.

A hydroxylated form of the imino acid proline. A deficiency in ASCORBIC ACID can result in impaired hydroxyproline formation.

Perisinusoidal cells of the liver, located in the space of Disse between HEPATOCYTES and sinusoidal endothelial cells.

Blockage in any part of the URETER causing obstruction of urine flow from the kidney to the URINARY BLADDER. The obstruction may be congenital, acquired, unilateral, bilateral, complete, partial, acute, or chronic. Depending on the degree and duration of the obstruction, clinical features vary greatly such as HYDRONEPHROSIS and obstructive nephropathy.

Infections with bacteria of the genus PSEUDOMONAS.

Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.

Spindle-shaped cells with characteristic CONTRACTILE PROTEINS and structures that contribute to the WOUND HEALING process. They occur in GRANULATION TISSUE and also in pathological processes such as FIBROSIS.

A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).

A solvent for oils, fats, lacquers, varnishes, rubber waxes, and resins, and a starting material in the manufacturing of organic compounds. Poisoning by inhalation, ingestion or skin absorption is possible and may be fatal. (Merck Index, 11th ed)

A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.

A species of gram-negative, aerobic, rod-shaped bacteria commonly isolated from clinical specimens (wound, burn, and urinary tract infections). It is also found widely distributed in soil and water. P. aeruginosa is a major agent of nosocomial infection.

Disorder characterized by a wide range of structural changes in PERITONEUM, resulting from fibrogenic or inflammatory processes. Peritoneal fibrosis is a common complication in patients receiving PERITONEAL DIALYSIS and contributes to its gradual decrease in efficiency.

A fibrillar collagen consisting of three identical alpha1(III) chains that is widely distributed in many tissues containing COLLAGEN TYPE I. It is particularly abundant in BLOOD VESSELS and may play a role in tissues with elastic characteristics.

Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.

The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.

Removal and pathologic examination of specimens in the form of small pieces of tissue from the living body.

A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.

The fluid excreted by the SWEAT GLANDS. It consists of water containing sodium chloride, phosphate, urea, ammonia, and other waste products.

Material coughed up from the lungs and expectorated via the mouth. It contains MUCUS, cellular debris, and microorganisms. It may also contain blood or pus.

Inflammation of the interstitial tissue of the kidney. This term is generally used for primary inflammation of KIDNEY TUBULES and/or surrounding interstitium. For primary inflammation of glomerular interstitium, see GLOMERULONEPHRITIS. Infiltration of the inflammatory cells into the interstitial compartment results in EDEMA, increased spaces between the tubules, and tubular renal dysfunction.

A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.

A strain of mice widely studied as a model for cystic fibrosis. These mice are generated from embryonic stem cells in which the CFTR (cystic fibrosis transmembrane conductance regulator) gene is inactivated by gene targeting. As a result, all mice have one copy of this altered gene in all their tissues. Mice homozygous for the disrupted gene exhibit many features common to young cystic fibrosis patients, including failure to thrive, meconium ileus, and alteration of mucous and serous glands.

The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.

The worsening of a disease over time. This concept is most often used for chronic and incurable diseases where the stage of the disease is an important determinant of therapy and prognosis.

Liver diseases caused by infections with PARASITES, such as tapeworms (CESTODA) and flukes (TREMATODA).

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

INFLAMMATION of the LIVER in humans that is caused by HEPATITIS C VIRUS lasting six months or more. Chronic hepatitis C can lead to LIVER CIRRHOSIS.

Infections with bacteria of the genus BURKHOLDERIA.

A species of BURKHOLDERIA considered to be an opportunistic human pathogen. It has been associated with various types of infections of nosocomial origin.

A chronic, acquired, idiopathic, progressive eruption of the skin that occurs in the context of RENAL FAILURE. It is sometimes accompanied by systemic fibrosis. The pathogenesis seems to be multifactorial, with postulated involvement of circulating fibrocytes. There is a strong association between this disorder and the use of gadolinium-based contrast agents.

Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.

Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.

A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.

Non-invasive imaging methods based on the mechanical response of an object to a vibrational or impulsive force. It is used for determining the viscoelastic properties of tissue, and thereby differentiating soft from hard inclusions in tissue such as microcalcifications, and some cancer lesions. Most techniques use ultrasound to create the images - eliciting the response with an ultrasonic radiation force and/or recording displacements of the tissue by Doppler ultrasonography.

Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.

Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.

Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.

Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.

The mucous membrane lining the RESPIRATORY TRACT, including the NASAL CAVITY; the LARYNX; the TRACHEA; and the BRONCHI tree. The respiratory mucosa consists of various types of epithelial cells ranging from ciliated columnar to simple squamous, mucous GOBLET CELLS, and glands containing both mucous and serous cells.

Washing liquid obtained from irrigation of the lung, including the BRONCHI and the PULMONARY ALVEOLI. It is generally used to assess biochemical, inflammatory, or infection status of the lung.

Measurement of the various processes involved in the act of respiration: inspiration, expiration, oxygen and carbon dioxide exchange, lung volume and compliance, etc.

RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.

Pathological processes of the KIDNEY or its component tissues.

Pathological processes involving any part of the LUNG.

Histochemical localization of immunoreactive substances using labeled antibodies as reagents.

A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.

Persistent abnormal dilatation of the bronchi.

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. Activated Smad3 can bind directly to DNA, and it regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

Elements of limited time intervals, contributing to particular results or situations.

A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function.

A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.

A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (LIPASE; PROTEASES; and AMYLASE) by the EXOCRINE PANCREAS into the DUODENUM. This condition is often associated with CYSTIC FIBROSIS and with chronic PANCREATITIS.

Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.

A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.

Levels within a diagnostic group which are established by various measurement criteria applied to the seriousness of a patient's disorder.

An enzyme that catalyzes the conversion of L-alanine and 2-oxoglutarate to pyruvate and L-glutamate. (From Enzyme Nomenclature, 1992) EC 2.6.1.2.

The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.

A crystalline compound used as a laboratory reagent in place of HYDROGEN SULFIDE. It is a potent hepatocarcinogen.

Diseases which have one or more of the following characteristics: they are permanent, leave residual disability, are caused by nonreversible pathological alteration, require special training of the patient for rehabilitation, or may be expected to require a long period of supervision, observation, or care. (Dictionary of Health Services Management, 2d ed)

Long convoluted tubules in the nephrons. They collect filtrate from blood passing through the KIDNEY GLOMERULUS and process this filtrate into URINE. Each renal tubule consists of a BOWMAN CAPSULE; PROXIMAL KIDNEY TUBULE; LOOP OF HENLE; DISTAL KIDNEY TUBULE; and KIDNEY COLLECTING DUCT leading to the central cavity of the kidney (KIDNEY PELVIS) that connects to the URETER.

Cell membrane glycoproteins that form channels to selectively pass chloride ions. Nonselective blockers include FENAMATES; ETHACRYNIC ACID; and TAMOXIFEN.

A member of the family of TISSUE INHIBITOR OF METALLOPROTEINASES. It is a N-glycosylated protein, molecular weight 28 kD, produced by a vast range of cell types and found in a variety of tissues and body fluids. It has been shown to suppress metastasis and inhibit tumor invasion in vitro.

The transference of either one or both of the lungs from one human or animal to another.

Measure of the maximum amount of air that can be expelled in a given number of seconds during a FORCED VITAL CAPACITY determination . It is usually given as FEV followed by a subscript indicating the number of seconds over which the measurement is made, although it is sometimes given as a percentage of forced vital capacity.

Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

The geometric and structural changes that the HEART VENTRICLES undergo, usually following MYOCARDIAL INFARCTION. It comprises expansion of the infarct and dilatation of the healthy ventricle segments. While most prevalent in the left ventricle, it can also occur in the right ventricle.

A genus of trichuroid nematodes parasitic in the liver and intestines of many mammals and birds. Two species, C. hepatica and C. philippinensis, produce often fatal infections in man.

Enzymes of the transferase class that catalyze the conversion of L-aspartate and 2-ketoglutarate to oxaloacetate and L-glutamate. EC 2.6.1.1.

The mucous lining of the NASAL CAVITY, including lining of the nostril (vestibule) and the OLFACTORY MUCOSA. Nasal mucosa consists of ciliated cells, GOBLET CELLS, brush cells, small granule cells, basal cells (STEM CELLS) and glands containing both mucous and serous cells.

The channels that collect and transport the bile secretion from the BILE CANALICULI, the smallest branch of the BILIARY TRACT in the LIVER, through the bile ductules, the bile ducts out the liver, and to the GALLBLADDER for storage.

An aminoglycoside, broad-spectrum antibiotic produced by Streptomyces tenebrarius. It is effective against gram-negative bacteria, especially the PSEUDOMONAS species. It is a 10% component of the antibiotic complex, NEBRAMYCIN, produced by the same species.

A strain of albino rat developed at the Wistar Institute that has spread widely at other institutions. This has markedly diluted the original strain.

The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.

The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.

A group of diseases in which the dominant feature is the involvement of the CARDIAC MUSCLE itself. Cardiomyopathies are classified according to their predominant pathophysiological features (DILATED CARDIOMYOPATHY; HYPERTROPHIC CARDIOMYOPATHY; RESTRICTIVE CARDIOMYOPATHY) or their etiological/pathological factors (CARDIOMYOPATHY, ALCOHOLIC; ENDOCARDIAL FIBROELASTOSIS).

A biosynthetic precursor of collagen containing additional amino acid sequences at the amino-terminal and carboxyl-terminal ends of the polypeptide chains.

A mammalian pancreatic extract composed of enzymes with protease, amylase and lipase activities. It is used as a digestant in pancreatic malfunction.

The identification of selected parameters in newborn infants by various tests, examinations, or other procedures. Screening may be performed by clinical or laboratory measures. A screening test is designed to sort out healthy neonates (INFANT, NEWBORN) from those not well, but the screening test is not intended as a diagnostic device, rather instead as epidemiologic.

The larger air passages of the lungs arising from the terminal bifurcation of the TRACHEA. They include the largest two primary bronchi which branch out into secondary bronchi, and tertiary bronchi which extend into BRONCHIOLES and PULMONARY ALVEOLI.

A receptor-regulated smad protein that undergoes PHOSPHORYLATION by ACTIVIN RECEPTORS, TYPE I. It regulates TRANSFORMING GROWTH FACTOR BETA and ACTIVIN signaling.

The tubular and cavernous organs and structures, by means of which pulmonary ventilation and gas exchange between ambient air and the blood are brought about.

A form of pneumoconiosis caused by inhalation of asbestos fibers which elicit potent inflammatory responses in the parenchyma of the lung. The disease is characterized by interstitial fibrosis of the lung, varying from scattered sites to extensive scarring of the alveolar interstitium.

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.

Blood tests that are used to evaluate how well a patient's liver is working and also to help diagnose liver conditions.

A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.

A group of phenotypically similar but genotypically distinct species (genomovars) in the genus BURKHOLDERIA. They are found in water, soil, and the rhizosphere of crop plants. They can act as opportunistic human pathogens and as plant growth promoting and biocontrol agents.

Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.

Small polyhedral outpouchings along the walls of the alveolar sacs, alveolar ducts and terminal bronchioles through the walls of which gas exchange between alveolar air and pulmonary capillary blood takes place.

Schistosomiasis caused by Schistosoma mansoni. It is endemic in Africa, the Middle East, South America, and the Caribbean and affects mainly the bowel, spleen, and liver.

Infections with nematodes of the order ENOPLIDA.

The viscous secretion of mucous membranes. It contains mucin, white blood cells, water, inorganic salts, and exfoliated cells.

Established cell cultures that have the potential to propagate indefinitely.

Extracts prepared from pancreatic tissue that may contain the pancreatic enzymes or other specific uncharacterized factors or proteins with specific activities. PANCREATIN is a specific extract containing digestive enzymes and used to treat pancreatic insufficiency.

A natural high-viscosity mucopolysaccharide with alternating beta (1-3) glucuronide and beta (1-4) glucosaminidic bonds. It is found in the UMBILICAL CORD, in VITREOUS BODY and in SYNOVIAL FLUID. A high urinary level is found in PROGERIA.

Agents that increase mucous excretion. Mucolytic agents, that is drugs that liquefy mucous secretions, are also included here.

The volume of air that is exhaled by a maximal expiration following a maximal inspiration.

A naturally occurring phenomenon where terminally differentiated cells dedifferentiate to the point where they can switch CELL LINEAGES. The cells then differentiate into other cell types.

Pathological processes of the LIVER.

The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.

A form of pneumoconiosis resulting from inhalation of dust containing crystalline form of SILICON DIOXIDE, usually in the form of quartz. Amorphous silica is relatively nontoxic.

A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.

One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.

Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.

An inhibitory smad protein that associates with TRANSFORMING GROWTH FACTOR BETA RECEPTORS and BONE MORPHOGENETIC PROTEIN RECEPTORS. It negatively regulates SIGNAL TRANSDUCTION PATHWAYS by inhibiting PHOSPHORYLATION of RECEPTOR-REGULATED SMAD PROTEINS.

Substances that reduce the growth or reproduction of BACTERIA.

Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.

The main structural component of the LIVER. They are specialized EPITHELIAL CELLS that are organized into interconnected plates called lobules.

Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons.

INFLAMMATION of the LIVER in humans caused by HEPATITIS C VIRUS, a single-stranded RNA virus. Its incubation period is 30-90 days. Hepatitis C is transmitted primarily by contaminated blood parenterally, and is often associated with transfusion and intravenous drug abuse. However, in a significant number of cases, the source of hepatitis C infection is unknown.

A diffuse parenchymal lung disease caused by inhalation of dust and by tissue reaction to their presence. These inorganic, organic, particulate, or vaporized matters usually are inhaled by workers in their occupational environment, leading to the various forms (ASBESTOSIS; BYSSINOSIS; and others). Similar air pollution can also have deleterious effects on the general population.

Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.

A nitrosamine derivative with alkylating, carcinogenic, and mutagenic properties. It causes serious liver damage and is a hepatocarcinogen in rodents.

The cartilaginous and membranous tube descending from the larynx and branching into the right and left main bronchi.

Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. They differ from classical hormones in that they are produced by a number of tissue or cell types rather than by specialized glands. They generally act locally in a paracrine or autocrine rather than endocrine manner.

A family of proteins that are involved in the translocation of signals from TGF-BETA RECEPTORS; BONE MORPHOGENETIC PROTEIN RECEPTORS; and other surface receptors to the CELL NUCLEUS. They were originally identified as a class of proteins that are related to the mothers against decapentaplegic protein, Drosophila and sma proteins from CAENORHABDITIS ELEGANS.

A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.

Identification of genetic carriers for a given trait.

One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.

A nodular organ in the ABDOMEN that contains a mixture of ENDOCRINE GLANDS and EXOCRINE GLANDS. The small endocrine portion consists of the ISLETS OF LANGERHANS secreting a number of hormones into the blood stream. The large exocrine portion (EXOCRINE PANCREAS) is a compound acinar gland that secretes several digestive enzymes into the pancreatic ductal system that empties into the DUODENUM.

Hardening of the KIDNEY due to infiltration by fibrous connective tissue (FIBROSIS), usually caused by renovascular diseases or chronic HYPERTENSION. Nephrosclerosis leads to renal ISCHEMIA.

The relatively long-lived phagocytic cell of mammalian tissues that are derived from blood MONOCYTES. Main types are PERITONEAL MACROPHAGES; ALVEOLAR MACROPHAGES; HISTIOCYTES; KUPFFER CELLS of the liver; and OSTEOCLASTS. They may further differentiate within chronic inflammatory lesions to EPITHELIOID CELLS or may fuse to form FOREIGN BODY GIANT CELLS or LANGHANS GIANT CELLS. (from The Dictionary of Cell Biology, Lackie and Dow, 3rd ed.)

Phenotypic changes of EPITHELIAL CELLS to MESENCHYME type, which increase cell mobility critical in many developmental processes such as NEURAL TUBE development. NEOPLASM METASTASIS and DISEASE PROGRESSION may also induce this transition.

Application of a ligature to tie a vessel or strangulate a part.

Chemical substances, produced by microorganisms, inhibiting or preventing the proliferation of neoplasms.

Infection of the lung often accompanied by inflammation.

A disturbance in the prooxidant-antioxidant balance in favor of the former, leading to potential damage. Indicators of oxidative stress include damaged DNA bases, protein oxidation products, and lipid peroxidation products (Sies, Oxidative Stress, 1991, pxv-xvi).

All of the processes involved in increasing CELL NUMBER including CELL DIVISION.

The thick green-to-black mucilaginous material found in the intestines of a full-term fetus. It consists of secretions of the INTESTINAL GLANDS; BILE PIGMENTS; FATTY ACIDS; AMNIOTIC FLUID; and intrauterine debris. It constitutes the first stools passed by a newborn.

The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.

INFLAMMATION of the LIVER in humans caused by HEPATITIS B VIRUS lasting six months or more. It is primarily transmitted by parenteral exposure, such as transfusion of contaminated blood or blood products, but can also be transmitted via sexual or intimate personal contact.

Salts of alginic acid that are extracted from marine kelp and used to make dental impressions and as absorbent material for surgical dressings.

A non-fibrillar collagen found in the structure of BASEMENT MEMBRANE. Collagen type IV molecules assemble to form a sheet-like network which is involved in maintaining the structural integrity of basement membranes. The predominant form of the protein is comprised of two alpha1(IV) subunits and one alpha2(IV) subunit, however, at least six different alpha subunits can be incorporated into the heterotrimer.

The administration of drugs by the respiratory route. It includes insufflation into the respiratory tract.

Damage to any compartment of the lung caused by physical, chemical, or biological agents which characteristically elicit inflammatory reaction. These inflammatory reactions can either be acute and dominated by NEUTROPHILS, or chronic and dominated by LYMPHOCYTES and MACROPHAGES.

Basic glycoprotein members of the SERPIN SUPERFAMILY that function as COLLAGEN-specific MOLECULAR CHAPERONES in the ENDOPLASMIC RETICULUM.

Washing out of the lungs with saline or mucolytic agents for diagnostic or therapeutic purposes. It is very useful in the diagnosis of diffuse pulmonary infiltrates in immunosuppressed patients.

The fibrous tissue that replaces normal tissue during the process of WOUND HEALING.

Gadolinium. An element of the rare earth family of metals. It has the atomic symbol Gd, atomic number 64, and atomic weight 157.25. Its oxide is used in the control rods of some nuclear reactors.

In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.

An enzyme that catalyzes the hydrolysis of proteins, including elastin. It cleaves preferentially bonds at the carboxyl side of Ala and Val, with greater specificity for Ala. EC 3.4.21.37.

The thin serous membrane enveloping the lungs (LUNG) and lining the THORACIC CAVITY. Pleura consist of two layers, the inner visceral pleura lying next to the pulmonary parenchyma and the outer parietal pleura. Between the two layers is the PLEURAL CAVITY which contains a thin film of liquid.

A secreted endopeptidase homologous with INTERSTITIAL COLLAGENASE, but which possesses an additional fibronectin-like domain.

An octapeptide that is a potent but labile vasoconstrictor. It is produced from angiotensin I after the removal of two amino acids at the C-terminal by ANGIOTENSIN CONVERTING ENZYME. The amino acid in position 5 varies in different species. To block VASOCONSTRICTION and HYPERTENSION effect of angiotensin II, patients are often treated with ACE INHIBITORS or with ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS.

Studies which start with the identification of persons with a disease of interest and a control (comparison, referent) group without the disease. The relationship of an attribute to the disease is examined by comparing diseased and non-diseased persons with regard to the frequency or levels of the attribute in each group.

A preparation of hog pancreatic enzymes standardized for lipase content.

Hypersensitivity reaction (ALLERGIC REACTION) to fungus ASPERGILLUS in an individual with long-standing BRONCHIAL ASTHMA. It is characterized by pulmonary infiltrates, EOSINOPHILIA, elevated serum IMMUNOGLOBULIN E, and skin reactivity to Aspergillus antigen.

Asbestos. Fibrous incombustible mineral composed of magnesium and calcium silicates with or without other elements. It is relatively inert chemically and used in thermal insulation and fireproofing. Inhalation of dust causes asbestosis and later lung and gastrointestinal neoplasms.

Chinese herbal or plant extracts which are used as drugs to treat diseases or promote general well-being. The concept does not include synthesized compounds manufactured in China.

Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)

Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation.

Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.

A non-specific host defense mechanism that removes MUCUS and other material from the LUNGS by ciliary and secretory activity of the tracheobronchial submucosal glands. It is measured in vivo as mucus transfer, ciliary beat frequency, and clearance of radioactive tracers.

Tomography using x-ray transmission and a computer algorithm to reconstruct the image.

An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.

The type species of gram negative, aerobic bacteria in the genus ACHROMOBACTER. Previously in the genus ALCALIGENES, the classification and nomenclature of this species has been frequently emended. The two subspecies, Achromobacter xylosoxidans subsp. denitrificans and Achromobacter xylosoxidans subsp. xylosoxidans are associated with infections.

The measurement of an organ in volume, mass, or heaviness.

Pyridine derivatives with one or more keto groups on the ring.

A common interstitial lung disease caused by hypersensitivity reactions of PULMONARY ALVEOLI after inhalation of and sensitization to environmental antigens of microbial, animal, or chemical sources. The disease is characterized by lymphocytic alveolitis and granulomatous pneumonitis.

Observation of a population for a sufficient number of persons over a sufficient number of years to generate incidence or mortality rates subsequent to the selection of the study group.

In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test.

A species of gram-negative bacteria that causes disease in plants. It is found commonly in the environment and is an opportunistic pathogen in humans.

Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).

Restoration of integrity to traumatized tissue.

A membrane of squamous EPITHELIAL CELLS, the mesothelial cells, covered by apical MICROVILLI that allow rapid absorption of fluid and particles in the PERITONEAL CAVITY. The peritoneum is divided into parietal and visceral components. The parietal peritoneum covers the inside of the ABDOMINAL WALL. The visceral peritoneum covers the intraperitoneal organs. The double-layered peritoneum forms the MESENTERY that suspends these organs from the abdominal wall.

Sweat-producing structures that are embedded in the DERMIS. Each gland consists of a single tube, a coiled body, and a superficial duct.

Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).

Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.

Proteins prepared by recombinant DNA technology.

A graphic means for assessing the ability of a screening test to discriminate between healthy and diseased persons; may also be used in other studies, e.g., distinguishing stimuli responses as to a faint stimuli or nonstimuli.

Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.

FIBROSIS of the hepatic parenchyma due to chronic excess ALCOHOL DRINKING.

Striated muscle cells found in the heart. They are derived from cardiac myoblasts (MYOBLASTS, CARDIAC).

Phenols substituted in any position by an amino group.

The relationship between the dose of an administered drug and the response of the organism to the drug.

Abnormal increase of resistance to blood flow within the hepatic PORTAL SYSTEM, frequently seen in LIVER CIRRHOSIS and conditions with obstruction of the PORTAL VEIN.

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.

An endopeptidase that is structurally similar to MATRIX METALLOPROTEINASE 2. It degrades GELATIN types I and V; COLLAGEN TYPE IV; and COLLAGEN TYPE V.

Techniques and strategies which include the use of coding sequences and other conventional or radical means to transform or modify cells for the purpose of treating or reversing disease conditions.

The movement of ions across energy-transducing cell membranes. Transport can be active, passive or facilitated. Ions may travel by themselves (uniport), or as a group of two or more ions in the same (symport) or opposite (antiport) directions.

A cytokine synthesized by T-LYMPHOCYTES that produces proliferation, immunoglobulin isotype switching, and immunoglobulin production by immature B-LYMPHOCYTES. It appears to play a role in regulating inflammatory and immune responses.

A complex of gadolinium with a chelating agent, diethylenetriamine penta-acetic acid (DTPA see PENTETIC ACID), that is given to enhance the image in cranial and spinal MRIs. (From Martindale, The Extra Pharmacopoeia, 30th ed, p706)

A class of statistical methods applicable to a large set of probability distributions used to test for correlation, location, independence, etc. In most nonparametric statistical tests, the original scores or observations are replaced by another variable containing less information. An important class of nonparametric tests employs the ordinal properties of the data. Another class of tests uses information about whether an observation is above or below some fixed value such as the median, and a third class is based on the frequency of the occurrence of runs in the data. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1284; Corsini, Concise Encyclopedia of Psychology, 1987, p764-5)

Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and presentation of the antigen to immunocompetent cells.

Invasion of the host RESPIRATORY SYSTEM by microorganisms, usually leading to pathological processes or diseases.

Enlargement of the LEFT VENTRICLE of the heart. This increase in ventricular mass is attributed to sustained abnormal pressure or volume loads and is a contributor to cardiovascular morbidity and mortality.

A chemokine that is a chemoattractant for MONOCYTES and may also cause cellular activation of specific functions related to host defense. It is produced by LEUKOCYTES of both monocyte and lymphocyte lineage and by FIBROBLASTS during tissue injury. It has specificity for CCR2 RECEPTORS.

The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.

A system of vessels in which blood, after passing through one capillary bed, is conveyed through a second set of capillaries before it returns to the systemic circulation. It pertains especially to the hepatic portal system.

Enhanced Th1 and dampened Th2 responses synergize to inhibit acute granulomatous and fibrotic responses in murine schistosomiasis mansoni. (1/5330)

In murine schistosomiasis mansoni, CD4(+) Th1 and Th2 cells participate in the ovum-induced granulomatous inflammation. Previous studies showed that the interleukin-12 (IL-12)-induced Th1 response strongly suppressed the Th2-cell-mediated pulmonary granuloma development in naive or primed mice. However, liver granulomas were only moderately suppressed in egg-vaccinated, recombinant IL-12 (rIL-12)-treated infected mice. The present study shows that repeated rIL-12 injections given during early granuloma development at 5 to 7 weeks after infection prolonged the Th1 phase and resulted in gamma interferon-mediated suppression of liver granulomas. The timing is crucial: if given at 6 to 8 weeks, during the Th2-dominated phase of florid granuloma growth, the treatment is ineffective. Daily injections of rIL-12 given between 5 and 7.5 weeks during the period of granuloma growth achieved a somewhat-stronger diminution in granuloma growth with less deposition of collagen but caused 60% mortality and liver pathology. In contrast, combined treatment with rIL-12 and anti-IL-4-anti-IL-10 monoclonal antibody (MAb) injections given during the Th2 phase strongly inhibited liver granuloma growth without mortality. The diminished inflammatory response was accompanied by less deposition of collagen in the liver. Moreover, neutralization of endogenous IL-12 by anti-IL-12 MAbs effectively decreased the early Th1 phase (between 5 and 6 weeks after infection) but not the developing Th2 phase (5 to 7 weeks) of granuloma development. These studies indicate that the granulomatous response in infected mice can be manipulated by utilizing the Th1-Th2-subset antagonism with potential salutary results in the amelioration of fibrous pathology. (+info)

Elevated carboxy terminal cross linked telopeptide of type I collagen in alcoholic cirrhosis: relation to liver and kidney function and bone metabolism. (2/5330)

BACKGROUND: The carboxy terminal cross linked telopeptide of type I collagen (ICTP) has been put forward as a marker of bone resorption. Patients with alcoholic liver disease may have osteodystrophy. AIMS: To assess circulating and regional concentrations of ICTP in relation to liver dysfunction, bone metabolism, and fibrosis. METHODS: In 15 patients with alcoholic cirrhosis and 20 controls, hepatic venous, renal venous, and femoral arterial concentrations of ICTP, and bone mass and metabolism were measured. RESULTS: Circulating ICTP was higher in patients with cirrhosis than in controls. No overall significant hepatic disposal or production was found in the patient or control groups but slightly increased production was found in a subset of patients with advanced disease. Significant renal extraction was observed in the controls, whereas only a borderline significant extraction was observed in the patients. Measurements of bone mass and metabolism indicated only a mild degree of osteodystrophy in the patients with cirrhosis. ICTP correlated significantly in the cirrhotic patients with hepatic and renal dysfunction and fibrosis, but not with measurements of bone mass or metabolism. CONCLUSIONS: ICTP is highly elevated in patients with cirrhosis, with no detectable hepatic net production or disposal. No relation between ICTP and markers of bone metabolism was identified, but there was a relation to indicators of liver dysfunction and fibrosis. As the cirrhotic patients conceivably only had mild osteopenia, the elevated ICTP in cirrhosis may therefore primarily reflect liver failure and hepatic fibrosis. (+info)

3D MRI of the membranous labyrinth. An age related comparison of MR findings in patients with labyrinthine fibrosis and in persons without inner ear symptoms. (3/5330)

PURPOSE: We compared MRI of the membranous labyrinth in patients with chronic non-neoplastic inner ear disease and MR signs of labyrinthine fibrosis and controls depending on their age, in order to establish whether there were any MR differences regarding patient age groups, control age groups and between the patients and controls themselves. MATERIALS AND METHODS: Clinical ENT examinations as well as a T2* weighted 3D CISS (Constructive Interference in Steady State) sequence with a slice thickness of 0.7 mm were performed. Our collective was subdivided as follows: 0-19 years (10 controls, 3 patients with chronic non-neoplastic inner ear disease), 20-49 years (55 controls, 8 patients), 50 years and older (40 controls, 22 patients). Detectability of labyrinthine structures (e.g. cochlea, vestibule, semicircular canals) and filling defects were evaluated. RESULTS: In the 3 age-groups of the control collective no significant differences were observed in the membranous labyrinth. However differences concerning labyrinthine detectability emerged between controls and patients in both the 20-49 years and 50 years and older age groups. In the patient collective the 3 age groups showed no significant discrepancy in the mean number of lesions. CONCLUSION: Filling defects of the membranous labyrinth on 3D CISS MR images are pathological even in older persons. We would therefore recommend high resolution T2* weighted MRI in the case of suspected labyrinthine fibrosis. (+info)

Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. (4/5330)

An experimental model of communicating hydrocephalus was developed based on intrathecal injection of human recombinant transforming growth factor-beta 1 (hrTGF-beta 1) in the mouse. To clarify the mechanism of this hydrocephalus model, the ultrastructure of the leptomeninx in the process of ventricular dilation was examined in C57/BL6 mice injected intrathecally with 60 ng of hrTGF-beta 1. The leptomeninx was examined at various periods after injection by light and electron microscopy. Immunostaining for fibroblasts and macrophages was also performed. Leptomeninx within a week after injection showed that the thin cytoplasmic processes of leptomeningeal cells formed a laminated structure with a meshwork, which was almost the same as the controls. In the second week, many cells with a round nucleus appeared in the leptomeninx. Immunohistochemically, these cells were positive for anti-fibroblast antibody and negative for anti-Mac-1 and anti-macrophage BM-8 antibodies. Three weeks later, the laminated structure was disrupted and abundant deposition of collagen fibers was found in the inter-cellular space of the leptomeninx. Such inter-meningeal fibrosis would disturb cerebrospinal fluid flow in the mouse leptomeninx and cause slowly progressive ventricular dilation. (+info)

Irradiation induces upregulation of CD31 in human endothelial cells. (5/5330)

Radiation-induced vascular injury is believed to be a major factor contributing to parenchymal atrophy, fibrosis and necrosis in normal tissue after radiotherapy. In this study irradiation of human umbilical vein endothelial cells (HUVECs) significantly increased adherence of U-937 cells in a time-dependent manner. Given the potential multifunctional role of CD31 in the vasculature we have examined the possible effects of irradiation on levels of CD31 expression in HUVECs. Irradiation upregulated CD31 expression on HUVECs, independently of initial plating density and radiation-induced changes such as cell number, cell cycle stage, or cell size. CD31 mRNA levels were raised in irradiated HUVECs relative to controls. Both CD31 mRNA and surface protein showed similar changes, suggesting that the increase in mRNA in irradiated HUVECs is responsible for the elevation in cell surface protein. A semi-quantitative study of tissue specimens from patients who had received radiotherapy indicated that CD31 staining in the blood vessels from irradiated tissues was increased compared with controls. Endothelial CD31 is important in the transmigration of leukocytes. We have demonstrated that the incorporation of monoclonal antibody to CD31 significantly inhibited the transmigration of human peripheral blood leukocytes through a monolayer of irradiated HUVECs. Taken together these data strongly suggest that irradiation induces a marked increase in CD31 expression on endothelial cells as part of a general response to irradiation. Its upregulation may play an important role in the development of radiation-induced normal tissue damage and thus is a possible target for therapeutic intervention. (+info)

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. (6/5330)

BACKGROUND: The pathogenesis of pancreatic fibrosis is unknown. In the liver, stellate cells play a major role in fibrogenesis by synthesising increased amounts of collagen and other extracellular matrix (ECM) proteins when activated by profibrogenic mediators such as cytokines and oxidant stress. AIMS: To determine whether cultured rat pancreatic stellate cells produce collagen and other ECM proteins, and exhibit signs of activation when exposed to the cytokines platelet derived growth factor (PDGF) or transforming growth factor beta (TGF-beta). METHODS: Cultured pancreatic stellate cells were immunostained for the ECM proteins procollagen III, collagen I, laminin, and fibronectin using specific polyclonal antibodies. For cytokine studies, triplicate wells of cells were incubated with increasing concentrations of PDGF or TGF-beta. RESULTS: Cultured pancreatic stellate cells stained strongly positive for all ECM proteins tested. Incubation of cells with 1, 5, and 10 ng/ml PDGF led to a significant dose related increase in cell counts as well as in the incorporation of 3H-thymidine into DNA. Stellate cells exposed to 0.25, 0.5, and 1 ng/ml TGF-beta showed a dose dependent increase in alpha smooth muscle actin expression and increased collagen synthesis. In addition, TGF-beta increased the expression of PDGF receptors on stellate cells. CONCLUSIONS: Pancreatic stellate cells produce collagen and other extracellular matrix proteins, and respond to the cytokines PDGF and TGF-beta by increased proliferation and increased collagen synthesis. These results suggest an important role for stellate cells in pancreatic fibrogenesis. (+info)

Cyclosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: roles of insulin-like growth factor I, transforming growth factor beta1, and platelet-derived growth factor. (7/5330)

To assess the direct fibrogenic effects of cyclosporin A (CyA) on the human tubulointerstitium, primary cultures of human renal proximal tubule cells (PTC) and renal cortical fibroblasts (CF) were incubated for 24 h with various concentrations of CyA. Cytotoxicity was confirmed in both cell populations by dose-dependent inhibition of thymidine incorporation, viability, and PTC apical sodium-hydrogen exchange activity (ethylisopropylamiloride-sensitive apical 22Na+ uptake). Compared with controls, both 500 and 1000 ng/ml CyA significantly stimulated CF collagen synthesis (proline incorporation 4.6 +/- 0.4, 6.5 +/- 0.8, and 7.1 +/- 1.0%, respectively; p <.05) and inhibited matrix metalloproteinase-2 (100%, 85.7 +/- 10.0%, and 38.8 +/- 9.2%) and matrix metalloproteinase-9 activity (100%, 110.6 +/- 19.0%, and 49.9 +/- 12.8%). CyA did not affect CF secretion of transforming growth factor beta1, but markedly stimulated insulin-like growth factor-I (IGF-I) secretion and inhibited secretion of both IGF-I binding protein-(IGFBP)-3 and IGFBP-2. CyA-induced CF collagen synthesis was abrogated by 5 microgram/ml anti-IGF-I receptor antibody, but not by 5 microgram/ml murine nonimmune globulin. Increasing concentrations of CyA progressively augmented PTC secretion of the fibrogenic cytokines transforming growth factor-beta1 and platelet-derived growth factor. These results indicate that clinically relevant concentrations of CyA are directly toxic to PTC and CF, irrespective of hemodynamic effects, and promote interstitial fibrosis by inhibiting matrix degradation and stimulating cortical fibroblast collagen synthesis via induction of autocrine IGF-I action. The latter effect may be further accentuated by the ability of CyA to augment secretion of transforming growth factor beta1 and platelet-derived growth factor by PTCs. (+info)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (8/5330)

BACKGROUND AND OBJECTIVE: The diagnostic and prognostic value of bone marrow biopsy (BMB) has been widely investigated in patients with chronic myeloproliferative disorders (CMPD). The present study is based on a review of the results of routine BMBs taken from 93 essential thrombocythemia (ET) patients at the time of diagnosis. DESIGN AND METHODS: The common BMB histologic parameters and clinico-hematologic variables were considered for diagnostic and prognostic purposes. Clinico-pathologic correlations were looked for univariately. Moreover, the diagnostic significance of the histologic findings was tested by means of cluster analysis. Overall survival and event-free survival were considered as prognostic endpoints. RESULTS: There were no correlations between the clinic and pathologic findings, and none of the histologic and clinical parameters was predictive of survival or the occurrence of major clinical events. Cluster analysis of the BMB findings revealed two distinct morphologic patterns: one was clearly myeloproliferative; the other had somewhat dysplastic features. The event-free and overall survival rates in the latter group were significantly worse (p = 0.0377 and p = 0.0162 respectively), with major ischemic events accounting for most of the difference in event-free survival. INTERPRETATION AND CONCLUSIONS: These results have no clearcut counterpart in the literature, but we feel that dysplastic BMB findings could be included in the definition of ET prognostic scores in order to allow therapeutic strategies to be adapted to the level of risk. (+info)

Fibrothorax Pulmonary fibrosis Cystic fibrosis Idiopathic pulmonary fibrosis (idiopathic meaning the cause is unknown) ... Glial scar Myocardial fibrosis has mainly two forms: Interstitial fibrosis, which has been described in congestive heart ... Replacement fibrosis, which indicates an older myocardial infarction. Healthy myocardium versus interstitial fibrosis in ... Progressive massive fibrosis (lungs); a complication of coal workers' pneumoconiosis Retroperitoneal fibrosis (soft tissue of ...

https://en.wikipedia.org/wiki/Fibrosis

... most common cause is idiopathic mediastinal fibrosis; less commonly histoplasmosis tuberculosis or unknown ... It is characterized by invasive, calcified fibrosis centered on lymph nodes that block major vessels and airways. In Europe, ... Mitchell IM, Saunders NR, Maher O, Lennox SC, Walker DR (1986). "Surgical treatment of idiopathic mediastinal fibrosis: report ... Mediastinitis Davis AM, Pierson RN, Loyd JE (2001). "Mediastinal fibrosis". Seminars in Respiratory Infections. 16 (2): 119-30 ...

https://en.wikipedia.org/wiki/Mediastinal_fibrosis

Malignant retroperitoneal fibrosis usually gives uneven MRI signals, is bulky, extends above the origins of renal arteries, or ... Biopsy should also be done if the location of fibrosis is atypical or if there is an inadequate response to initial treatment. ... Retroperitoneal fibrosis or Ormond's disease is a disease featuring the proliferation of fibrous tissue in the retroperitoneum ... Additionally, malignant retroperitoneal fibrosis less frequently displaces the ureters medially when compared to other causes ...

https://en.wikipedia.org/wiki/Retroperitoneal_fibrosis

Replacement fibrosis, which indicates an older infarction. Micrograph of healthy myocardium versus interstitial fibrosis in ... The most obvious treatment for cardiac valve fibrosis or fibrosis in other locations, consists of stopping the stimulatory drug ... Following are types of myocardial fibrosis: Interstitial fibrosis, which is unspecific, and has been described in congestive ... Cardiac fibrosis is common in non-human great apes in human care. The term idiopathic myocardial fibrosis was coined to ...

https://en.wikipedia.org/wiki/Cardiac_fibrosis

Fibrosis Mukherjee PK, Das AK (1980). "Injection fibrosis in the quadriceps femoris muscle in children". J Bone Joint Surg Am. ... Injection fibrosis is a complication of intramuscular injection, occurring especially often in infants and children. Injections ...

https://en.wikipedia.org/wiki/Injection_fibrosis

The name "cystic fibrosis" refers to the characteristic fibrosis and cysts that form within the pancreas. Cystic fibrosis ... Search GeneCards for genes involved in cystic fibrosis Cystic Fibrosis Mutation Database "Cystic Fibrosis". MedlinePlus. U.S. ... "Orphanet: Cystic fibrosis". www.orpha.net. Retrieved 29 July 2022. Hodson M, Geddes D, Bush A, eds. (2012). Cystic Fibrosis ( ... Cochrane Cystic Fibrosis and Genetic Disorders Group) (March 2021). "Dornase alfa for cystic fibrosis". The Cochrane Database ...

https://en.wikipedia.org/wiki/Cystic_fibrosis

"Pulmonary Fibrosis". MedicineNet, Inc. Archived from the original on 19 July 2014. Retrieved 26 July 2014. "Pulmonary fibrosis ... Misdiagnosis is common because, while overall pulmonary fibrosis is not rare, each individual type of pulmonary fibrosis is ... "Pulmonary Fibrosis". medlineplus.gov. Retrieved 20 December 2019. "Pulmonary fibrosis - Symptoms and causes". Mayo Clinic. ... and the resulting stiffness or decreased compliance makes pulmonary fibrosis a restrictive lung disease. Pulmonary fibrosis is ...

https://en.wikipedia.org/wiki/Pulmonary_fibrosis

Basic and Clinical Aspects of Pulmonary Fibrosis. CRC Press. pp. 391-. ISBN 978-0-8493-8927-6. WYATT JP, RIDDELL AC (1949). " ...

https://en.wikipedia.org/wiki/Bauxite_fibrosis

Shinerama List of cystic fibrosis organizations Cystic Fibrosis Foundation Cystic Fibrosis Trust "Annual Report 2009: Keeping a ... Cystic Fibrosis Canada's mandate is to help individuals with cystic fibrosis, principally by funding cystic fibrosis research ... Cystic Fibrosis Canada raises funds in order to promote public awareness and support research and high-quality cystic fibrosis ... "Cystic Fibrosis Canada: About us: What we do: Mission". Cystic Fibrosis Canada. 2009-08-06. Archived from the original on 2011- ...

https://en.wikipedia.org/wiki/Cystic_Fibrosis_Canada

The Cystic Fibrosis Foundation has been a pioneer of cystic fibrosis treatment, having played a major role in the development ... "About the Cystic Fibrosis Foundation". Cystic Fibrosis Foundation. Retrieved 2013-02-19. "FDA Approves Drug That Could Treat 90 ... "The Danger of Cross Infections for Those Living With Cystic Fibrosis - Cystic Fibrosis News Today". Retrieved 2020-09-29. ... "Board of Trustees". Cystic Fibrosis Foundation. Retrieved May 6, 2018. "Advisory Council". Cystic Fibrosis Foundation. ...

https://en.wikipedia.org/wiki/Cystic_Fibrosis_Foundation

... is a rare syndrome that involves fibrosis of skin, joints, eyes, and internal organs. NSF is ... "nephrogenic systemic fibrosis" to better describe its systemic nature. The term "gadolinium-associated systemic fibrosis" has ... Kalb RE, Helm TN, Sperry H, Thakral C, Abraham JL, Kanal E (March 2008). "Gadolinium-induced nephrogenic systemic fibrosis in a ... Daftari Besheli L, Aran S, Shaqdan K, Kay J, Abujudeh H (July 2014). "Current status of nephrogenic systemic fibrosis". ...

https://en.wikipedia.org/wiki/Nephrogenic_systemic_fibrosis

... is clinically divided into three stages: Stage 1: Stomatitis Stage 2: Fibrosis a- Early lesions, ... Severe oral submucous fibrosis is irreversible. Moderate oral submucous fibrosis is reversible with cessation of habit and ... Oral Submucous Fibrosis at eMedicine Donoghue M, Basandi PS, Adarsh H, Madhushankari GS, Selvamani M, Nayak P (2015). "Habit- ... Group IVA: Trismus is severe, with an interincisal distance of less than 15 mm and extensive fibrosis of all the oral mucosa. ...

https://en.wikipedia.org/wiki/Oral_submucous_fibrosis

List of cystic fibrosis organizations Cystic Fibrosis Foundation Canadian Cystic Fibrosis Foundation UK Cystic Fibrosis Gene ... The aim of the Cystic Fibrosis Trust research is to understand, treat and cure cystic fibrosis. The Cystic Fibrosis Trust is ... The Cystic Fibrosis Trust (stylised as Cystic Fibrosis), is a UK-based national charity founded in 1964, dealing with all ... The Cystic Fibrosis Trust sets the national standard on clinical care; provides and funds a UK CF Clinical Database; and ...

https://en.wikipedia.org/wiki/Cystic_Fibrosis_Trust

Wikimedia Commons has media related to Idiopathic pulmonary fibrosis. Idiopathic pulmonary fibrosis at Curlie (All articles ... December 2011). "Familial pulmonary fibrosis is the strongest risk factor for idiopathic pulmonary fibrosis". Respiratory ... "Idiopathic Pulmonary Fibrosis (an Update) and Progressive Pulmonary Fibrosis in Adults: An Official ATS/ERS/JRS/ALAT Clinical ... "Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in ...

https://en.wikipedia.org/wiki/Idiopathic_pulmonary_fibrosis

... (PMF), characterized by the development of large conglomerate masses of dense fibrosis (usually in ... Progressive massive fibrosis increased during the period 1970-2016 among coal miners in central Appalachia who filed for black ... Primary Source: Annals of the American Thoracic Society Source Reference: Almberg KS, et al "Progressive massive fibrosis ... fibrosis, and emphysema.[citation needed] There are also some mechanical factors involved in the pathogenesis of Complex ...

https://en.wikipedia.org/wiki/Progressive_massive_fibrosis

"Síndrome de fibrosis por radiación". OncoLink. Trustees of the University of Pennsylvania. Retrieved 2 May 2022. "Fibrosis ... "Pulmonary fibrosis". Cleveland Clinic. Cleveland Clinic. 2021. Retrieved 2 May 2022. "Idiopathic pulmonary fibrosis". AMBOSS. ... Radiation fibrosis syndrome is a human illness. It occurs as a result of cell death, and can be caused by radiotherapy. It is ... Hematic biometry Imaging tests such as X-rays or tomography Pulmonary function tests Biopsy Pulmonary fibrosis is not currently ...

https://en.wikipedia.org/wiki/Radiation_Fibrosis_Syndrome

... usually presents in adolescent or young adulthood, but onset of signs and symptoms can range from ... The fibrosis would affect resistance in portal veins leading to portal hypertension.[citation needed] The condition is usually ... Embryogenically, congenital hepatic fibrosis is due to malformation of the duct plate, a round structure appearing in the ... Congenital hepatic fibrosis is an inherited fibrocystic liver disease associated with proliferation of interlobular bile ducts ...

https://en.wikipedia.org/wiki/Congenital_hepatic_fibrosis

... is a chronic lung disease of horses. There is evidence that the disease is caused by ... The distribution between two patterns can be seen as a large, whitish until tan and firm nodules of fibrosis. There are noticed ... Poth T, Niedermaier G, Hermanns W (January 2009). "Equine multinodular pulmonary fibrosis in association with an EHV-5 ... Signs of equine multinodular pulmonary fibrosis are mainly weight loss, fever, respiratory distress and depression. ...

https://en.wikipedia.org/wiki/Equine_multinodular_pulmonary_fibrosis

... (CFRD) is diabetes specifically caused by cystic fibrosis, a genetic condition. Cystic ... Cystic fibrosis Lek N, Acerini CL (January 2010). "Cystic fibrosis related diabetes mellitus - diagnostic and management ... Kayani K, Mohammed R, Mohiaddin H (2018-02-20). "Cystic Fibrosis-Related Diabetes". Frontiers in Endocrinology. 9: 20. doi: ... Articles with short description, Short description matches Wikidata, Diabetes, Pulmonology, Endocrinology, Cystic fibrosis). ...

https://en.wikipedia.org/wiki/Cystic_fibrosis–related_diabetes

... (NCPF) is a chronic liver disease and type of non-cirrhotic portal hypertension (NCPH). It is ... Sarin, SK (December 2002). "Non-cirrhotic portal fibrosis". Journal of Gastroenterology and Hepatology. 17 Suppl 3: S214-23. ... "Non-cirrhotic portal fibrosis: one disease with many names? An analysis from morphological study of native explant livers with ...

https://en.wikipedia.org/wiki/Non-cirrhotic_portal_fibrosis

... in one copy of the CFTR gene and a cystic fibrosis-causing mutation in the other copy of CFTR. Cystic fibrosis: More than 1,800 ... The Cystic Fibrosis Transmembrane Conductance Regulator Protein The Human Gene Mutation Database - CFTR Records Cystic Fibrosis ... "Cystic fibrosis transmembrane conductance regulator and the etiology and pathogenesis of cystic fibrosis". FASEB Journal. 6 (10 ... Wong LJ, Alper OM, Wang BT, Lee MH, Lo SY (July 2003). "Two novel null mutations in a Taiwanese cystic fibrosis patient and a ...

https://en.wikipedia.org/wiki/Cystic_fibrosis_transmembrane_conductance_regulator

... (CPFE), describes a medical syndrome involving both pulmonary fibrosis and emphysema ... Wand, O; Kramer, MR (January 2018). "The Syndrome of Combined Pulmonary Fibrosis and Emphysema - CPFE". Harefuah. 157 (1): 28- ... Jankowich, MD; Rounds, SI (January 2012). "Combined pulmonary fibrosis and emphysema syndrome: a review". Chest. 141 (1): 222- ... Cottin, V; Cordier JF (June 2005). "Combined pulmonary fibrosis and emphysema: an experimental and clinically relevant ...

https://en.wikipedia.org/wiki/Combined_pulmonary_fibrosis_and_emphysema

Cystic Fibrosis Foundation (CFF), a US non-profit providing the means to cure and control cystic fibrosis. Cystic Fibrosis ... Cystic Fibrosis Australia Cystic Fibrosis Community Care "CFWA - Cystic Fibrosis WA". www.cfwa.org.au. Retrieved 2019-09-05. ... Cystic-L Cystic Fibrosis Canada Cystic Fibrosis Foundation Cystic Fibrosis Lifestyle Foundation Archived 2008-02-25 at the ... Cystic Fibrosis Canada (CCFF), a Canada-wide health charity, which funds cystic fibrosis research and care. ...

https://en.wikipedia.org/wiki/List_of_cystic_fibrosis_organizations

GeneReviews/NCBI/NIH/UW entry on Congenital Fibrosis of the Extraocular Muscles OMIM entries on Congenital Fibrosis of the ... Congenital fibrosis of the extraocular muscles is a class of rare genetic disorders affecting one or more of the muscles that ... Individuals with congenital fibrosis of the extraocular muscles (CFEOM) have varying degrees of ophthalmoplegia (an inability ... PMID 20074521.{{cite journal}}: CS1 maint: multiple names: authors list (link) Laughlin, R.C. Congenital fibrosis of the ...

https://en.wikipedia.org/wiki/Congenital_fibrosis_of_the_extraocular_muscles

The following notable people have or had cystic fibrosis. "'Real World: San Diego' Alum Frankie Abernathy Dead At 25". MTV. ... "Kerrang!". Robinson, Georgina (June 10, 2014). "Cystic fibrosis no barrier for Nathan Charles as he prepares for Test debut". ... "Lisa Bentley Triumphs Over CF". Canadian Cystic Fibrosis Foundation. July 7, 2004. Archived from the original on September 27, ... Travis Flores Webster, Philip; Coates, Sam (November 29, 2006). "Gordon Brown's baby son diagnosed with cystic fibrosis". The ...

https://en.wikipedia.org/wiki/List_of_people_diagnosed_with_cystic_fibrosis

Muscle biopsy shows fibrosis and fatty infiltration. Skin biopsy shows fibrosis and alterations of the elastic network. This ... Hereditary fibrosing poikiloderma with tendon contractures, myopathy and pulmonary fibrosis is a rare genetic syndrome ... The main characteristics of this condition are poikiloderma, tendon contractures and progressive pulmonary fibrosis. Other ... and pulmonary fibrosis. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Stephens K, Amemiya A, (editors). GeneReview ...

https://en.wikipedia.org/wiki/Hereditary_fibrosing_poikiloderma_with_tendon_contractures,_myopathy,_and_pulmonary_fibrosis

... though it is unclear exactly how this results in fibrosis. The precise mechanisms producing the fibrosis are not entirely clear ... Fibrosis can affect one or both of the two layers of tissue forming the pleura-the visceral pleura adjacent to the lung and the ... Fibrosis in the pleura may be produced intentionally using a technique called pleurodesis to prevent recurrent punctured lung ( ... Exposure to certain substances, such as asbestos, can cause generalised fibrosis of the lungs, which may involve the pleura and ...

https://en.wikipedia.org/wiki/Fibrothorax

If two cystic fibrosis carriers have children, they have a 25 percent chance of producing offspring having two copies of the ... Not all heterozygotes for recessive lethal alleles will show a mutant phenotype, as is the case for cystic fibrosis carriers. ... Ratjen, Felix; Döring, Gerd (February 2003). "Cystic fibrosis". Lancet. 361 (9358): 681-689. doi:10.1016/S0140-6736(03)12567-6 ...

https://en.wikipedia.org/wiki/Lethal_allele

Endomyocardial Fibrosis. The National Medical Journal of India. Vol. 6. Oxford University Press. pp. 212-216. ISBN 978-0-19- ...

https://en.wikipedia.org/wiki/M._S._Valiathan

"Cystic Fibrosis Canada". www.cysticfibrosis.ca. Retrieved 2017-11-30. O'Sullivan BP, Freedman SD (May 2009). "Cystic fibrosis ... Cystic fibrosis is an autosomal recessive disorder that causes a variety of symptoms and complications, the most common of ... If both parents have a mutated CFTR (cystic fibrosis transmembrane conductance regulator) protein, then their children have a ... Many Mendelian disorders stem from dominant point mutations within genes, including cystic fibrosis, beta-thalassemia, sickle- ...

https://en.wikipedia.org/wiki/Germline_mutation

Cystic fibrosis (CF) is a genetic disorder that causes problems with breathing and digestion. CF affects about 35,000 people in ... CF results from mutations (changes) in the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) gene, which has ... National Institutes of Health, National Heart, Lung, and Blood Institute: Cystic Fibrosis ...

https://www.cdc.gov/genomics/disease/cystic_fibrosis.htm

Congenital fibrosis of the extraocular muscles (CFEOM) is a disorder of the nervous system that affects use of the muscles that ... FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 2. *FIBROSIS OF EXTRAOCULAR MUSCLES, CONGENITAL, 3A, WITH OR WITHOUT EXTRAOCULAR ... Congenital fibrosis of the extraocular muscles (CFEOM) is a disorder of the nervous system that affects use of the muscles that ... Congenital Fibrosis of the Extraocular Muscles Overview. 2004 Apr 27 [updated 2021 Aug 12]. In: Adam MP, Mirzaa GM, Pagon RA, ...

https://medlineplus.gov/genetics/condition/congenital-fibrosis-of-the-extraocular-muscles/

The Cystic Fibrosis Foundation is the worlds leader in the search for a cure for CF and supports a broad range of research ... Cystic Fibrosis Foundation Announces Irena Barisic as Next Chief Operating and Financial Officer ... Newly Expanded Cystic Fibrosis Foundation Lab Will Enable More Research Into Genetic Therapies ... Cystic Fibrosis Foundation (national office). 4550 Montgomery Ave.. Suite 1100 N. Bethesda, MD 20814 ...

https://www.cff.org/?f%5B0%5D=date%3A2021-01-22T00%3A00%3A00__2022-01-22T23%3A59%3A59&f%5B1%5D=date%3A2021-08-19T00%3A00%3A00__2022-08-19T23%3A59%3A59&f%5B2%5D=type-category%3ACommunity%20Posts&s=&page=14

https://www.cysticfibrosis.ca/blog/2022/05/

About Bonnell Foundation: Living with Cystic Fibrosis. Our mission is to give emotional and/or financial support to parents who ... Bonnell Foundation: Living with Cystic Fibrosis. PO Box 1215. Royal Oak, MI, USA ... have a loved one with cystic fibrosis. Our hope is one day no CF parent will experience the pain of losing a child to this ...

https://rarediseases.org/organizations/bonnell-foundation-living-with-cystic-fibrosis/

Environmental or occupational exposure may be contributing to the burden of pulmonary fibrosis - even though asbestos is ... MUNICH - Some cases of idiopathic pulmonary fibrosis (IPF) may be due to environmental or occupational exposure to asbestos, ...

http://www.medscape.com/viewarticle/831713

Autor desconhecido (‎2011)‎. Gadolinium: nephrogenic systemic fibrosis. WHO Drug Information 2011; 25(‎4)‎ : 365 https://apps. ...

https://apps.who.int:80/iris/handle/10665/109244?locale-attribute=pt&

... is a disease of fibrosis of the skin and internal organs reminiscent but distinct from scleroderma or scleromyxedema. It is ... Nephrogenic systemic fibrosis (NSF), also known as nephrogenic fibrosing dermopathy (NFD), ... Role of endothelin-1/endothelin receptor signaling in fibrosis and calcification in nephrogenic systemic fibrosis. Exp Dermatol ... encoded search term (Nephrogenic Systemic Fibrosis) and Nephrogenic Systemic Fibrosis What to Read Next on Medscape ...

https://emedicine.medscape.com/article/1097889-medication

Fundraise or donate to The Pulmonary Fibrosis Trust with JustGiving, the worlds leading online fundraising platform, helping ... The Pulmonary Fibrosis Trust. We provide personal support to people affected by Pulmonary Fibrosis. ... About The Pulmonary Fibrosis Trust. We offer practical, emotional and financial support where there is a need. We also raise ...

https://www.justgiving.com/pulmonaryfibrosistrust

Review the use of anti-inflammatory medications for cystic fibrosis. ... The clinical features of cystic fibrosis occur as a result of mutations in the cystic fibrosis trans-membrane conductance ... Cystic fibrosis is the most common lethal, genetically inherited disorder among Caucasians.[4,6,8,11] ... Clearing the Air in Cystic Fibrosis: Airway Clearance Approaches for Patients 0.5 CME / CE / ABIM MOC Credits ...

https://www.medscape.com/viewarticle/503819

Read medical definition of Fibrosis, pulmonary

https://www.medicinenet.com/fibrosis_pulmonary/definition.htm

... J Paediatr Child Health. 1998 Aug;34(4): ... in children with cystic fibrosis (CF) and symptoms of gastro-oesophageal reflux (GOR). To measure the effects of PD on GOR in ...

https://pubmed.ncbi.nlm.nih.gov/9727172/?dopt=Abstract

1985)‎. Cystic fibrosis*. Bulletin of the World Health Organization, 63 (‎1)‎, 1 - 10. https://extranet.who.int/iris/restricted ...

https://extranet.who.int/iris/restricted/handle/10665/265082?locale-attribute=en&

Cystic fibrosis is a symbol of how difficult it is to move from genetic discoveries to new medicines. The gene for the disorder ... In a potentially historic victory, a drug targeted to a specific genetic defect has improved the ability of cystic fibrosis ... The result is a big win for developer Vertex Pharmaceuticals and its partner, the Cystic Fibrosis Foundation, a patient group. ... Another measure of the drugs effect: patients with cystic fibrosis have elevated levels of chloride ions in their sweat, ...

https://www.forbes.com/sites/matthewherper/2011/02/23/vertex-may-make-history-with-cystic-fibrosis-drug/?partner=yahootix

Excessive cardiac fibrosis is an important factor in the progression of various forms of cardiac disease and heart failure2. ... Adoptive transfer of CAR T cells against the fibroblast marker FAP reduces cardiac fibrosis and restores function after cardiac ... Here we demonstrate the efficacy of redirected T cell immunotherapy to specifically target pathological cardiac fibrosis in ... However, clinical interventions and therapies that target fibrosis remain limited3. ...

https://www.nature.com/articles/s41586-019-1546-z?error=cookies_not_supported&code=fb3f3673-e303-4a8b-a763-86d782852c12

my 4year old just had two sweat test done and both were positive.we now have to wait 4-6 weeks for a genetic test to come back.my question is can a pe...

https://www.healingwell.com/community/default.aspx?f=18&m=611916

... Pediatrics. 1968 Jan;41(1):7-17. ...

https://pubmed.ncbi.nlm.nih.gov/5635490/?dopt=AbstractPlus

... kids with cystic fibrosis have some specific nutritional needs. Find out ways to help your child with CF grow healthy and ... Fibrosis quística y nutrición. What Is Cystic Fibrosis?. Cystic fibrosis (CF) is a genetic disorder that affects the bodys ... How Does Cystic Fibrosis Affect Nutrition?. The sticky mucus from cystic fibrosis can block normal absorption of key nutrients ... Kids with cystic fibrosis have some specific nutritional needs:. Salt. Kids with CF lose more salt in their sweat than their ...

https://www.kidshealth.org/Hackensack/en/parents/cf-nutrition.html?WT.ac=p-ra

fibrosis Clinical Research Trial Listings on CenterWatch ...

https://www.centerwatch.com/clinical-trials/listings/search/?q=fibrosis&page=105

Evaluating the Impact of Precision Medicine: How Ivacaftor Reduces Hospitalizations of Patients with Cystic Fibrosis. Precision ... cystic fibrosis - Genomics and Precision Health Blog ...

https://blogs.cdc.gov/genomics/tag/cystic-fibrosis/

This sample meal plan for teens with cystic fibrosis provides a days worth of meals that add up to about 3,750 calories. ...

https://kidshealth.org/CookChildrens/en/teens/cf-menu.html?WT.ac=t-ra

ABOUT CYSTIC FIBROSIS Cystic fibrosis (CF) is a life-threatening genetic disease that causes serious lung infections and ... the Cystic Fibrosis Foundation Therapeutics Inc. (the nonprofit affiliate of the Cystic Fibrosis Foundation), which recently ... PTC124 shows activity in cystic fibrosis; Phase 2 proof-of-concept data published in Lancet 1 of the first therapies to address ... Life sciences/Genetics/Human genetics/Medical genetics/Genetic disorders/Cystic fibrosis * /Life sciences/Genetics/Molecular ...

https://www.eurekalert.org/news-releases/687559

A history on the medical condition cystic fibrosis (CF) ... Cystic Fibrosis: How CF Affects the Body * Cystic Fibrosis: ... The earliest reference to cystic fibrosis is in medical texts around 1595. These texts linked salty skin and damage to the ... In particular, the Cystic Fibrosis Foundation (United States) has played a significant role in developing the current model of ... "cystic fibrosis of the pancreas" based on her autopsy findings of children who died of malnutrition. Other physicians of the ...

https://www.nationaljewish.org/conditions/cystic-fibrosis-cf/history

... [Abstract Citrullinated Vimentin Mediates ... Synopsis Citrullinated Vimentin Mediates Development and Progression of Lung Fibrosis] Li FJ, Surolia R, Li H, Wang Z, Liu G, ...

https://www.niehs.nih.gov/research/resources/articles_journals/recent/pdf_2021/citrullinated_vimentin_mediates_development_and_progression_of_lung_fibrosis_.cfm

Learn about pulmonary fibrosis, a covert killer ...

https://www.greatfallstribune.com/story/life/health-and-fitness/2014/08/19/raising-awareness-covert-killer-pulmonary-fibrosis/14274851/

Cystic fibrosis is an autosomal recessive disorder, and most carriers of the gene are asymptomatic. ... Cystic fibrosis (CF) is the most common lethal inherited disease in white persons. ... Cystic Fibrosis Foundation. Fibrosis Foundation Patient registry Annual Report 2008. Bethesda, MD: Cystic Fibrosis Foundation; ... Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation. J Pediatr. 2017 Feb. 181S:S4-S15.e1. [ ...

https://emedicine.medscape.com/article/1001602-clinical

Canon Biomedical has launched a series of cystic fibrosis genotyping assays as part of its Novallele line. Novallele assays ... Canon Biomedical has launched a series of cystic fibrosis genotyping assays as part of its Novallele line. Novallele assays ...

https://www.genomeweb.com/resources/new-product/canon-novallele-cystic-fibrosis-genotyping-assays

Cystic fibrosis can be treated with airway clearance, antibiotics, mucolytics, lung transplant, and a promising new class of ... A Phase 2 study of the safety, pharmacokinetics, and efficacy of anabasum (JBT-101) in cystic fibrosis (CF). J Cystic Fibrosis ... Enteral tube feeding for individuals with cystic fibrosis: Cystic Fibrosis Foundation evidence-informed guidelines. J Cyst ... Can you cure cystic fibrosis with a lung transplant? It wont completely cure you. After a lung transplant, you wont have ...

https://www.verywellhealth.com/is-there-a-cure-for-cystic-fibrosis-998216

Cystic Fibrosis Research, Inc. (CFRI) was formed in 1975 by a group of parents whose children were not expected to survive ... We hope that you enjoy Cystic Fibrosis week at the ATS and find these resources helpful in advancing your understanding of this ... This is an incredible improvement from the 1950s, when an infant born with cystic fibrosis was not expected to survive to ... Our vision is Inform, engage and empower the cystic fibrosis community to reach the highest possible quality of life, as we ...

https://www.thoracic.org/patients/lung-disease-week/2020/cystic-fibrosis-week/

Anatomy39

Organisms15

Diseases63

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Phenomena and Processes29

Disciplines and Occupations1

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Health Care16

Enhanced Th1 and dampened Th2 responses synergize to inhibit acute granulomatous and fibrotic responses in murine schistosomiasis mansoni. (1/5330)

Elevated carboxy terminal cross linked telopeptide of type I collagen in alcoholic cirrhosis: relation to liver and kidney function and bone metabolism. (2/5330)

3D MRI of the membranous labyrinth. An age related comparison of MR findings in patients with labyrinthine fibrosis and in persons without inner ear symptoms. (3/5330)

Ultramicroscopic structures of the leptomeninx of mice with communicating hydrocephalus induced by human recombinant transforming growth factor-beta 1. (4/5330)

Irradiation induces upregulation of CD31 in human endothelial cells. (5/5330)

Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis. (6/5330)

Cyclosporin exerts a direct fibrogenic effect on human tubulointerstitial cells: roles of insulin-like growth factor I, transforming growth factor beta1, and platelet-derived growth factor. (7/5330)

Prognostic significance of bone marrow biopsy in essential thrombocythemia. (8/5330)

No FAQ available that match "fibrosis"

Fibrosis

Cystic Fibrosis

Cystic Fibrosis Transmembrane Conductance Regulator

Endomyocardial Fibrosis

Idiopathic Pulmonary Fibrosis

Liver Cirrhosis

Retroperitoneal Fibrosis

Bleomycin

Oral Submucous Fibrosis

Liver Cirrhosis, Experimental

Lung

Hydroxyproline

Hepatic Stellate Cells

Ureteral Obstruction

Pseudomonas Infections

Disease Models, Animal

Myofibroblasts

Collagen

Carbon Tetrachloride

Transforming Growth Factor beta

Pseudomonas aeruginosa

Peritoneal Fibrosis

Collagen Type III

Fibroblasts

Collagen Type I

Biopsy

Liver

Sweat

Sputum

Mice, Inbred C57BL

Nephritis, Interstitial

Scleroderma, Systemic

Mice, Inbred CFTR

Myocardium

Disease Progression

Liver Diseases, Parasitic

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Hepatitis C, Chronic

Burkholderia Infections

Burkholderia cepacia

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Epithelial Cells

Mice, Knockout

Connective Tissue Growth Factor

Elasticity Imaging Techniques

Chlorides

Biological Markers

Cells, Cultured

Fatty Liver

Respiratory Mucosa

Bronchoalveolar Lavage Fluid

Respiratory Function Tests

RNA, Messenger

Kidney Diseases

Lung Diseases

Immunohistochemistry

Lung Diseases, Interstitial

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Smad3 Protein

Time Factors

Inflammation

Extracellular Matrix

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Actins

Rats, Sprague-Dawley

Severity of Illness Index

Alanine Transaminase

Signal Transduction

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Tissue Inhibitor of Metalloproteinase-1

Lung Transplantation

Forced Expiratory Volume

Carbon Tetrachloride Poisoning

Mutation

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