A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
A family of small polypeptide growth factors that share several common features including a strong affinity for HEPARIN, and a central barrel-shaped core region of 140 amino acids that is highly homologous between family members. Although originally studied as proteins that stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor family.
Specific molecular sites or structures on cell membranes that react with FIBROBLAST GROWTH FACTORS (both the basic and acidic forms), their analogs, or their antagonists to elicit or to inhibit the specific response of the cell to these factors. These receptors frequently possess tyrosine kinase activity.
A 17-kDa single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. It binds to HEPARIN, which potentiates its biological activity and protects it from proteolysis. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages, and also has chemotactic and mitogenic activities. It was originally named acidic fibroblast growth factor based upon its chemical properties and to distinguish it from basic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 2).
A fibroblast growth factor receptor with specificity for FIBROBLAST GROWTH FACTORS; HEPARAN SULFATE PROTEOGLYCAN; and NEURONAL CELL ADHESION MOLECULES. Several variants of the receptor exist due to multiple ALTERNATIVE SPLICING of its mRNA. Fibroblast growth factor receptor 1 is a tyrosine kinase that transmits signals through the MAP KINASE SIGNALING SYSTEM.
A fibroblast growth factor receptor that is found in two isoforms. One receptor isoform is found in the MESENCHYME and is activated by FIBROBLAST GROWTH FACTOR 2. A second isoform of fibroblast growth factor receptor 2 is found mainly in EPITHELIAL CELLS and is activated by FIBROBLAST GROWTH FACTOR 7 and FIBROBLAST GROWTH FACTOR 10. Mutation of the gene for fibroblast growth factor receptor 2 can result in craniosynostotic syndromes (e.g., APERT SYNDROME; and CROUZON SYNDROME).
Connective tissue cells which secrete an extracellular matrix rich in collagen and other macromolecules.
A fibroblast growth factor receptor that regulates CHONDROCYTE growth and CELL DIFFERENTIATION. Mutations in the gene for fibroblast growth factor receptor 3 have been associated with ACHONDROPLASIA; THANATOPHORIC DYSPLASIA and NEOPLASTIC CELL TRANSFORMATION.
A fibroblast growth factor that is a mitogen for KERATINOCYTES. It activates FIBROBLAST GROWTH FACTOR RECEPTOR 2B and is involved in LUNG and limb development.
A fibroblast growth factor receptor that is mainly expressed in LUNG; KIDNEY; PANCREAS; and SPLEEN. It also plays an important role in SKELETAL MUSCLE development and can contribute to NEOPLASTIC CELL TRANSFORMATION.
A 6-kDa polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. Epidermal growth factor exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and EPITHELIAL CELLS. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form.
A fibroblast growth factor that was originally identified as a mitogen for GLIAL CELLS. It is expressed primarily in NEURONS.
A HEPARIN binding fibroblast growth factor that may play a role in LIMB BUDS development.
A fibroblast growth factor that is a specific mitogen for EPITHELIAL CELLS. It binds a complex of HEPARAN SULFATE and FIBROBLAST GROWTH FACTOR RECEPTOR 2B.
Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others.
The original member of the family of endothelial cell growth factors referred to as VASCULAR ENDOTHELIAL GROWTH FACTORS. Vascular endothelial growth factor-A was originally isolated from tumor cells and referred to as "tumor angiogenesis factor" and "vascular permeability factor". Although expressed at high levels in certain tumor-derived cells it is produced by a wide variety of cell types. In addition to stimulating vascular growth and vascular permeability it may play a role in stimulating VASODILATION via NITRIC OXIDE-dependent pathways. Alternative splicing of the mRNA for vascular endothelial growth factor A results in several isoforms of the protein being produced.
Signal molecules that are involved in the control of cell growth and differentiation.
The fission of a CELL. It includes CYTOKINESIS, when the CYTOPLASM of a cell is divided, and CELL NUCLEUS DIVISION.
A fibroblast growth factor that preferentially activates FIBROBLAST GROWTH FACTOR RECEPTOR 4. It was initially identified as an androgen-induced growth factor and plays a role in regulating growth of human BREAST NEOPLASMS and PROSTATIC NEOPLASMS.
The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway.
Mitogenic peptide growth hormone carried in the alpha-granules of platelets. It is released when platelets adhere to traumatized tissues. Connective tissue cells near the traumatized region respond by initiating the process of replication.
A fibroblast growth factor that may play a role in regulation of HAIR FOLLICLE phenotype. Spontaneous mutation of the gene for this protein results in a strain of MICE with abnormally long hair, referred to as angora mice.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
These growth factors are soluble mitogens secreted by a variety of organs. The factors are a mixture of two single chain polypeptides which have affinity to heparin. Their molecular weight are organ and species dependent. They have mitogenic and chemotactic effects and can stimulate endothelial cells to grow and synthesize DNA. The factors are related to both the basic and acidic FIBROBLAST GROWTH FACTORS but have different amino acid sequences.
RNA sequences that serve as templates for protein synthesis. Bacterial mRNAs are generally primary transcripts in that they do not require post-transcriptional processing. Eukaryotic mRNA is synthesized in the nucleus and must be exported to the cytoplasm for translation. Most eukaryotic mRNAs have a sequence of polyadenylic acid at the 3' end, referred to as the poly(A) tail. The function of this tail is not known for certain, but it may play a role in the export of mature mRNA from the nucleus as well as in helping stabilize some mRNA molecules by retarding their degradation in the cytoplasm.
A factor synthesized in a wide variety of tissues. It acts synergistically with TGF-alpha in inducing phenotypic transformation and can also act as a negative autocrine growth factor. TGF-beta has a potential role in embryonal development, cellular differentiation, hormone secretion, and immune function. TGF-beta is found mostly as homodimer forms of separate gene products TGF-beta1, TGF-beta2 or TGF-beta3. Heterodimers composed of TGF-beta1 and 2 (TGF-beta1.2) or of TGF-beta2 and 3 (TGF-beta2.3) have been isolated. The TGF-beta proteins are synthesized as precursor proteins.
A class of cellular receptors that have an intrinsic PROTEIN-TYROSINE KINASE activity.
A family of angiogenic proteins that are closely-related to VASCULAR ENDOTHELIAL GROWTH FACTOR A. They play an important role in the growth and differentiation of vascular as well as lymphatic endothelial cells.
Hormonally active polypeptides that can induce the transformed phenotype when added to normal, non-transformed cells. They have been found in culture fluids from retrovirally transformed cells and in tumor-derived cells as well as in non-neoplastic sources. Their transforming activities are due to the simultaneous action of two otherwise unrelated factors, TRANSFORMING GROWTH FACTOR ALPHA and TRANSFORMING GROWTH FACTOR BETA.
Established cell cultures that have the potential to propagate indefinitely.
A fibroblast growth factor that is expressed primarily during development.
A well-characterized basic peptide believed to be secreted by the liver and to circulate in the blood. It has growth-regulating, insulin-like, and mitogenic activities. This growth factor has a major, but not absolute, dependence on GROWTH HORMONE. It is believed to be mainly active in adults in contrast to INSULIN-LIKE GROWTH FACTOR II, which is a major fetal growth factor.
Multifunctional growth factor which regulates both cell growth and cell motility. It exerts a strong mitogenic effect on hepatocytes and primary epithelial cells. Its receptor is PROTO-ONCOGENE PROTEINS C-MET.
Factors which enhance the growth potentialities of sensory and sympathetic nerve cells.
Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs.
Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories.
A fibroblast growth factor that was initially identified based on its sequence similarity to FIBROBLAST GROWTH FACTOR 4. It is found in MYOBLASTS and plays an important role in MUSCLE DEVELOPMENT.
Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity.
An EPIDERMAL GROWTH FACTOR related protein that is found in a variety of tissues including EPITHELIUM, and maternal DECIDUA. It is synthesized as a transmembrane protein which can be cleaved to release a soluble active form which binds to the EGF RECEPTOR.
The development of new BLOOD VESSELS during the restoration of BLOOD CIRCULATION during the healing process.
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Cell surface receptors that bind growth or trophic factors with high affinity, triggering intracellular responses which influence the growth, differentiation, or survival of cells.
The introduction of a phosphoryl group into a compound through the formation of an ester bond between the compound and a phosphorus moiety.
All of the processes involved in increasing CELL NUMBER including CELL DIVISION.
Histochemical localization of immunoreactive substances using labeled antibodies as reagents.
The most divergent of the known fibroblast growth factor receptors. It does not contain an intracellular TYROSINE KINASE domain and has been shown to interact with FIBROBLAST GROWTH FACTOR 2. Fibroblast growth factor receptor 5 is found primarily in skeletal tissue.
Cell lines whose original growing procedure consisted being transferred (T) every 3 days and plated at 300,000 cells per plate (J Cell Biol 17:299-313, 1963). Lines have been developed using several different strains of mice. Tissues are usually fibroblasts derived from mouse embryos but other types and sources have been developed as well. The 3T3 lines are valuable in vitro host systems for oncogenic virus transformation studies, since 3T3 cells possess a high sensitivity to CONTACT INHIBITION.
Regulatory proteins and peptides that are signaling molecules involved in the process of PARACRINE COMMUNICATION. They are generally considered factors that are expressed by one cell and are responded to by receptors on another nearby cell. They are distinguished from HORMONES in that their actions are local rather than distal.
A subtype of transforming growth factor beta that is synthesized by a wide variety of cells. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta 1 and TGF-beta1 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor. Defects in the gene that encodes TGF-beta1 are the cause of CAMURATI-ENGELMANN SYNDROME.
Proteins prepared by recombinant DNA technology.
A pathologic process consisting of the proliferation of blood vessels in abnormal tissues or in abnormal positions.
The uptake of naked or purified DNA by CELLS, usually meaning the process as it occurs in eukaryotic cells. It is analogous to bacterial transformation (TRANSFORMATION, BACTERIAL) and both are routinely employed in GENE TRANSFER TECHNIQUES.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation.
The phenotypic manifestation of a gene or genes by the processes of GENETIC TRANSCRIPTION and GENETIC TRANSLATION.
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. It is also called nucleotide sequence.
NERVE GROWTH FACTOR is the first of a series of neurotrophic factors that were found to influence the growth and differentiation of sympathetic and sensory neurons. It is comprised of alpha, beta, and gamma subunits. The beta subunit is responsible for its growth stimulating activity.
Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components.
The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.
Substances that stimulate mitosis and lymphocyte transformation. They include not only substances associated with LECTINS, but also substances from streptococci (associated with streptolysin S) and from strains of alpha-toxin-producing staphylococci. (Stedman, 25th ed)
The order of amino acids as they occur in a polypeptide chain. This is referred to as the primary structure of proteins. It is of fundamental importance in determining PROTEIN CONFORMATION.
A heteropolysaccharide that is similar in structure to HEPARIN. It accumulates in individuals with MUCOPOLYSACCHARIDOSIS.
Domesticated bovine animals of the genus Bos, usually kept on a farm or ranch and used for the production of meat or dairy products or for heavy labor.
Identification of proteins or peptides that have been electrophoretically separated by blot transferring from the electrophoresis gel to strips of nitrocellulose paper, followed by labeling with antibody probes.
Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.
The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
Protein kinases that catalyze the PHOSPHORYLATION of TYROSINE residues in proteins with ATP or other nucleotides as phosphate donors.
A variation of the PCR technique in which cDNA is made from RNA via reverse transcription. The resultant cDNA is then amplified using standard PCR protocols.
Specific receptors on cell membranes that react with PLATELET-DERIVED GROWTH FACTOR, its analogs, or antagonists. The alpha PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR ALPHA) and the beta PDGF receptor (RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA) are the two principle types of PDGF receptors. Activation of the protein-tyrosine kinase activity of the receptors occurs by ligand-induced dimerization or heterodimerization of PDGF receptor types.
Restoration of integrity to traumatized tissue.
The middle germ layer of an embryo derived from three paired mesenchymal aggregates along the neural tube.
A technique that localizes specific nucleic acid sequences within intact chromosomes, eukaryotic cells, or bacterial cells through the use of specific nucleic acid-labeled probes.
The developmental entity of a fertilized chicken egg (ZYGOTE). The developmental process begins about 24 h before the egg is laid at the BLASTODISC, a small whitish spot on the surface of the EGG YOLK. After 21 days of incubation, the embryo is fully developed before hatching.
A family of closely related RECEPTOR PROTEIN-TYROSINE KINASES that bind vascular endothelial growth factors. They share a cluster of seven extracellular Ig-like domains which are important for ligand binding. They are highly expressed in vascular endothelial cells and are critical for the physiological and pathological growth, development and maintenance of blood and lymphatic vessels.
Cell surface proteins that bind signalling molecules external to the cell with high affinity and convert this extracellular event into one or more intracellular signals that alter the behavior of the target cell (From Alberts, Molecular Biology of the Cell, 2nd ed, pp693-5). Cell surface receptors, unlike enzymes, do not chemically alter their ligands.
A well-characterized neutral peptide believed to be secreted by the LIVER and to circulate in the BLOOD. It has growth-regulating, insulin-like and mitogenic activities. The growth factor has a major, but not absolute, dependence on SOMATOTROPIN. It is believed to be a major fetal growth factor in contrast to INSULIN-LIKE GROWTH FACTOR I, which is a major growth factor in adults.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism.
A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine).
Elements of limited time intervals, contributing to particular results or situations.
A polypeptide substance comprising about one third of the total protein in mammalian organisms. It is the main constituent of SKIN; CONNECTIVE TISSUE; and the organic substance of bones (BONE AND BONES) and teeth (TOOTH).
The relationship between the dose of an administered drug and the response of the organism to the drug.
The process in which substances, either endogenous or exogenous, bind to proteins, peptides, enzymes, protein precursors, or allied compounds. Specific protein-binding measures are often used as assays in diagnostic assessments.
Agents that induce or stimulate PHYSIOLOGIC ANGIOGENESIS or PATHOLOGIC ANGIOGENESIS.
Ubiquitous macromolecules associated with the cell surface and extracellular matrix of a wide range of cells of vertebrate and invertebrate tissues. They are essential cofactors in cell-matrix adhesion processes, in cell-cell recognition systems, and in receptor-growth factor interactions. (From Cancer Metastasis Rev 1996; 15(2): 177-86; Hepatology 1996; 24(3): 524-32)
Products of proto-oncogenes. Normally they do not have oncogenic or transforming properties, but are involved in the regulation or differentiation of cell growth. They often have protein kinase activity.
Culture media containing biologically active components obtained from previously cultured cells or tissues that have released into the media substances affecting certain cell functions (e.g., growth, lysis).
Relatively undifferentiated cells that retain the ability to divide and proliferate throughout postnatal life to provide progenitor cells that can differentiate into specialized cells.
The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability.
A condition of an abnormally low level of PHOSPHATES in the blood.
The rate dynamics in chemical or physical systems.
A meshwork-like substance found within the extracellular space and in association with the basement membrane of the cell surface. It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere.
A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
A cell line derived from cultured tumor cells.
A 200-230-kDa tyrosine kinase receptor for vascular endothelial growth factors found primarily in endothelial and hematopoietic cells and their precursors. VEGFR-2 is important for vascular and hematopoietic development, and mediates almost all endothelial cell responses to VEGF.
Glycoproteins which have a very high polysaccharide content.
Conversion of an inactive form of an enzyme to one possessing metabolic activity. It includes 1, activation by ions (activators); 2, activation by cofactors (coenzymes); and 3, conversion of an enzyme precursor (proenzyme or zymogen) to an active enzyme.
Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations.
A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.
A CCN protein family member that regulates a variety of extracellular functions including CELL ADHESION; CELL MIGRATION; and EXTRACELLULAR MATRIX synthesis. It is found in hypertrophic CHONDROCYTES where it may play a role in CHONDROGENESIS and endochondral ossification.
Congenital craniostenosis with syndactyly.
A superfamily of PROTEIN-SERINE-THREONINE KINASES that are activated by diverse stimuli via protein kinase cascades. They are the final components of the cascades, activated by phosphorylation by MITOGEN-ACTIVATED PROTEIN KINASE KINASES, which in turn are activated by mitogen-activated protein kinase kinase kinases (MAP KINASE KINASE KINASES).
Mutant mice homozygous for the recessive gene "nude" which fail to develop a thymus. They are useful in tumor studies and studies on immune responses.
Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.
One of the mechanisms by which CELL DEATH occurs (compare with NECROSIS and AUTOPHAGOCYTOSIS). Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and cytoplasm, chromatin cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic DNA; (DNA FRAGMENTATION); at internucleosomal sites. This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth.
The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION.
Cells that line the inner and outer surfaces of the body by forming cellular layers (EPITHELIUM) or masses. Epithelial cells lining the SKIN; the MOUTH; the NOSE; and the ANAL CANAL derive from ectoderm; those lining the RESPIRATORY SYSTEM and the DIGESTIVE SYSTEM derive from endoderm; others (CARDIOVASCULAR SYSTEM and LYMPHATIC SYSTEM) derive from mesoderm. Epithelial cells can be classified mainly by cell shape and function into squamous, glandular and transitional epithelial cells.
Premature closure of one or more CRANIAL SUTURES. It often results in plagiocephaly. Craniosynostoses that involve multiple sutures are sometimes associated with congenital syndromes such as ACROCEPHALOSYNDACTYLIA; and CRANIOFACIAL DYSOSTOSIS.
The entity of a developing mammal (MAMMALS), generally from the cleavage of a ZYGOTE to the end of embryonic differentiation of basic structures. For the human embryo, this represents the first two months of intrauterine development preceding the stages of the FETUS.
The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment.
Different forms of a protein that may be produced from different GENES, or from the same gene by ALTERNATIVE SPLICING.
Strains of mice in which certain GENES of their GENOMES have been disrupted, or "knocked-out". To produce knockouts, using RECOMBINANT DNA technology, the normal DNA sequence of the gene being studied is altered to prevent synthesis of a normal gene product. Cloned cells in which this DNA alteration is successful are then injected into mouse EMBRYOS to produce chimeric mice. The chimeric mice are then bred to yield a strain in which all the cells of the mouse contain the disrupted gene. Knockout mice are used as EXPERIMENTAL ANIMAL MODELS for diseases (DISEASE MODELS, ANIMAL) and to clarify the functions of the genes.
An autosomal dominant disorder that is the most frequent form of short-limb dwarfism. Affected individuals exhibit short stature caused by rhizomelic shortening of the limbs, characteristic facies with frontal bossing and mid-face hypoplasia, exaggerated lumbar lordosis, limitation of elbow extension, GENU VARUM, and trident hand. (Online Mendelian Inheritance in Man, http://www.ncbi.nlm.nih.gov/Omim, MIM#100800, April 20, 2001)
Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
Cellular DNA-binding proteins encoded by the sis gene (GENES, SIS). c-sis proteins make up the B chain of PLATELET-DERIVED GROWTH FACTOR. Overexpression of c-sis causes tumorigenesis.
A 180-kDa VEGF receptor found primarily in endothelial cells that is essential for vasculogenesis and vascular maintenance. It is also known as Flt-1 (fms-like tyrosine kinase receptor-1). A soluble, alternatively spliced isoform of the receptor may serve as a binding protein that regulates the availability of various ligands for VEGF receptor binding and signal transduction.
Recombinant proteins produced by the GENETIC TRANSLATION of fused genes formed by the combination of NUCLEIC ACID REGULATORY SEQUENCES of one or more genes with the protein coding sequences of one or more genes.
A negative regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins.
Short sequences (generally about 10 base pairs) of DNA that are complementary to sequences of messenger RNA and allow reverse transcriptases to start copying the adjacent sequences of mRNA. Primers are used extensively in genetic and molecular biology techniques.
Cell-surface proteins that bind transforming growth factor beta and trigger changes influencing the behavior of cells. Two types of transforming growth factor receptors have been recognized. They differ in affinity for different members of the transforming growth factor beta family and in cellular mechanisms of action.
CULTURE MEDIA free of serum proteins but including the minimal essential substances required for cell growth. This type of medium avoids the presence of extraneous substances that may affect cell proliferation or unwanted activation of cells.
A severe form of neonatal dwarfism with very short limbs. All cases have died at birth or later in the neonatal period.
A 44-kDa extracellular signal-regulated MAP kinase that may play a role the initiation and regulation of MEIOSIS; MITOSIS; and postmitotic functions in differentiated cells. It phosphorylates a number of TRANSCRIPTION FACTORS; and MICROTUBULE-ASSOCIATED PROTEINS.
An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade.
Cellular signaling in which a factor secreted by a cell affects other cells in the local environment. This term is often used to denote the action of INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS on surrounding cells.
A PDGF receptor that binds specifically to the PDGF-B chain. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process.
Laboratory mice that have been produced from a genetically manipulated EGG or EMBRYO, MAMMALIAN.
Theoretical representations that simulate the behavior or activity of biological processes or diseases. For disease models in living animals, DISEASE MODELS, ANIMAL is available. Biological models include the use of mathematical equations, computers, and other electronic equipment.
Autosomal dominant CRANIOSYNOSTOSIS with shallow ORBITS; EXOPHTHALMOS; and maxillary hypoplasia.
A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. Activation of the enzyme by phosphorylation leads to its translocation into the nucleus where it acts upon specific transcription factors. p40 MAPK and p41 MAPK are isoforms.
One or more layers of EPITHELIAL CELLS, supported by the basal lamina, which covers the inner or outer surfaces of the body.
A CELL LINE derived from a PHEOCHROMOCYTOMA of the rat ADRENAL MEDULLA. PC12 cells stop dividing and undergo terminal differentiation when treated with NERVE GROWTH FACTOR, making the line a useful model system for NERVE CELL differentiation.
The number of CELLS of a specific kind, usually measured per unit volume or area of sample.
The minute vessels that connect the arterioles and venules.
A non-essential amino acid. In animals it is synthesized from PHENYLALANINE. It is also the precursor of EPINEPHRINE; THYROID HORMONES; and melanin.
Methods for maintaining or growing CELLS in vitro.
Bone-growth regulatory factors that are members of the transforming growth factor-beta superfamily of proteins. They are synthesized as large precursor molecules which are cleaved by proteolytic enzymes. The active form can consist of a dimer of two identical proteins or a heterodimer of two related bone morphogenetic proteins.
Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.
Compounds or agents that combine with an enzyme in such a manner as to prevent the normal substrate-enzyme combination and the catalytic reaction.
Highly specialized EPITHELIAL CELLS that line the HEART; BLOOD VESSELS; and lymph vessels, forming the ENDOTHELIUM. They are polygonal in shape and joined together by TIGHT JUNCTIONS. The tight junctions allow for variable permeability to specific macromolecules that are transported across the endothelial layer.
Insulin-like polypeptides made by the liver and some fibroblasts and released into the blood when stimulated by SOMATOTROPIN. They cause sulfate incorporation into collagen, RNA, and DNA synthesis, which are prerequisites to cell division and growth of the organism.
Proteins which are found in membranes including cellular and intracellular membranes. They consist of two types, peripheral and integral proteins. They include most membrane-associated enzymes, antigenic proteins, transport proteins, and drug, hormone, and lectin receptors.
Adherence of cells to surfaces or to other cells.
Naturally occurring or experimentally induced animal diseases with pathological processes sufficiently similar to those of human diseases. They are used as study models for human diseases.
In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. The reaction is efficient, specific, and extremely sensitive. Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships.
Cell surface receptors that bind NERVE GROWTH FACTOR; (NGF) and a NGF-related family of neurotrophic factors that includes neurotrophins, BRAIN-DERIVED NEUROTROPHIC FACTOR and CILIARY NEUROTROPHIC FACTOR.
A mitogen-activated protein kinase subfamily that is widely expressed and plays a role in regulation of MEIOSIS; MITOSIS; and post mitotic functions in differentiated cells. The extracellular signal regulated MAP kinases are regulated by a broad variety of CELL SURFACE RECEPTORS and can be activated by certain CARCINOGENS.
Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases.
DNA sequences which are recognized (directly or indirectly) and bound by a DNA-dependent RNA polymerase during the initiation of transcription. Highly conserved sequences within the promoter include the Pribnow box in bacteria and the TATA BOX in eukaryotes.
Any liquid or solid preparation made specifically for the growth, storage, or transport of microorganisms or other types of cells. The variety of media that exist allow for the culturing of specific microorganisms and cell types, such as differential media, selective media, test media, and defined media. Solid media consist of liquid media that have been solidified with an agent such as AGAR or GELATIN.
A PDGF receptor that binds specifically to both PDGF-A chains and PDGF-B chains. It contains a protein-tyrosine kinase activity that is involved in SIGNAL TRANSDUCTION.
Single-stranded complementary DNA synthesized from an RNA template by the action of RNA-dependent DNA polymerase. cDNA (i.e., complementary DNA, not circular DNA, not C-DNA) is used in a variety of molecular cloning experiments as well as serving as a specific hybridization probe.
The nonstriated involuntary muscle tissue of blood vessels.
The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.
A continuous cell line of high contact-inhibition established from NIH Swiss mouse embryo cultures. The cells are useful for DNA transfection and transformation studies. (From ATCC [Internet]. Virginia: American Type Culture Collection; c2002 [cited 2002 Sept 26]. Available from http://www.atcc.org/)
The parts of a macromolecule that directly participate in its specific combination with another molecule.
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action in neoplastic tissue.
An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed.
The development of anatomical structures to create the form of a single- or multi-cell organism. Morphogenesis provides form changes of a part, parts, or the whole organism.
Mode of communication wherein a bound hormone affects the function of the cell type that produced the hormone.
Filamentous proteins that are the main constituent of the thin filaments of muscle fibers. The filaments (known also as filamentous or F-actin) can be dissociated into their globular subunits; each subunit is composed of a single polypeptide 375 amino acids long. This is known as globular or G-actin. In conjunction with MYOSINS, actin is responsible for the contraction and relaxation of muscle.
Eukaryotic cell line obtained in a quiescent or stationary phase which undergoes conversion to a state of unregulated growth in culture, resembling an in vitro tumor. It occurs spontaneously or through interaction with viruses, oncogenes, radiation, or drugs/chemicals.
A process whereby multiple RNA transcripts are generated from a single gene. Alternative splicing involves the splicing together of other possible sets of EXONS during the processing of some, but not all, transcripts of the gene. Thus a particular exon may be connected to any one of several alternative exons to form a mature RNA. The alternative forms of mature MESSENGER RNA produce PROTEIN ISOFORMS in which one part of the isoforms is common while the other parts are different.
Connective tissue cells of an organ found in the loose connective tissue. These are most often associated with the uterine mucosa and the ovary as well as the hematopoietic system and elsewhere.
A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
Glycoproteins found on the surfaces of cells, particularly in fibrillar structures. The proteins are lost or reduced when these cells undergo viral or chemical transformation. They are highly susceptible to proteolysis and are substrates for activated blood coagulation factor VIII. The forms present in plasma are called cold-insoluble globulins.
A TGF-beta subtype that was originally identified as a GLIOBLASTOMA-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T LYMPHOCYTES. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
A protein-tyrosine kinase receptor that is closely related in structure to the INSULIN RECEPTOR. Although commonly referred to as the IGF-I receptor, it binds both IGF-I and IGF-II with high affinity. It is comprised of a tetramer of two alpha and two beta subunits which are derived from cleavage of a single precursor protein. The beta subunit contains an intrinsic tyrosine kinase domain.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Phosphotransferases that catalyzes the conversion of 1-phosphatidylinositol to 1-phosphatidylinositol 3-phosphate. Many members of this enzyme class are involved in RECEPTOR MEDIATED SIGNAL TRANSDUCTION and regulation of vesicular transport with the cell. Phosphatidylinositol 3-Kinases have been classified both according to their substrate specificity and their mode of action within the cell.
The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.
Immunologic method used for detecting or quantifying immunoreactive substances. The substance is identified by first immobilizing it by blotting onto a membrane and then tagging it with labeled antibodies.
Immunoglobulin molecules having a specific amino acid sequence by virtue of which they interact only with the ANTIGEN (or a very similar shape) that induced their synthesis in cells of the lymphoid series (especially PLASMA CELLS).
A molecule that binds to another molecule, used especially to refer to a small molecule that binds specifically to a larger molecule, e.g., an antigen binding to an antibody, a hormone or neurotransmitter binding to a receptor, or a substrate or allosteric effector binding to an enzyme. Ligands are also molecules that donate or accept a pair of electrons to form a coordinate covalent bond with the central metal atom of a coordination complex. (From Dorland, 27th ed)
A subfamily in the family MURIDAE, comprising the hamsters. Four of the more common genera are Cricetus, CRICETULUS; MESOCRICETUS; and PHODOPUS.
Members of the class of compounds composed of AMINO ACIDS joined together by peptide bonds between adjacent amino acids into linear, branched or cyclical structures. OLIGOPEPTIDES are composed of approximately 2-12 amino acids. Polypeptides are composed of approximately 13 or more amino acids. PROTEINS are linear polypeptides that are normally synthesized on RIBOSOMES.
Macromolecular organic compounds that contain carbon, hydrogen, oxygen, nitrogen, and usually, sulfur. These macromolecules (proteins) form an intricate meshwork in which cells are embedded to construct tissues. Variations in the relative types of macromolecules and their organization determine the type of extracellular matrix, each adapted to the functional requirements of the tissue. The two main classes of macromolecules that form the extracellular matrix are: glycosaminoglycans, usually linked to proteins (proteoglycans), and fibrous proteins (e.g., COLLAGEN; ELASTIN; FIBRONECTINS; and LAMININ).
Transport proteins that carry specific substances in the blood or across cell membranes.
A group of enzymes that catalyzes the phosphorylation of serine or threonine residues in proteins, with ATP or other nucleotides as phosphate donors.
A TGF-beta subtype that plays role in regulating epithelial-mesenchymal interaction during embryonic development. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta3 and TGF-beta3 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.
The action of a drug in promoting or enhancing the effectiveness of another drug.
The sum of the weight of all the atoms in a molecule.
Test for tissue antigen using either a direct method, by conjugation of antibody with fluorescent dye (FLUORESCENT ANTIBODY TECHNIQUE, DIRECT) or an indirect method, by formation of antigen-antibody complex which is then labeled with fluorescein-conjugated anti-immunoglobulin antibody (FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT). The tissue is then examined by fluorescence microscopy.
The transparent anterior portion of the fibrous coat of the eye consisting of five layers: stratified squamous CORNEAL EPITHELIUM; BOWMAN MEMBRANE; CORNEAL STROMA; DESCEMET MEMBRANE; and mesenchymal CORNEAL ENDOTHELIUM. It serves as the first refracting medium of the eye. It is structurally continuous with the SCLERA, avascular, receiving its nourishment by permeation through spaces between the lamellae, and is innervated by the ophthalmic division of the TRIGEMINAL NERVE via the ciliary nerves and those of the surrounding conjunctiva which together form plexuses. (Cline et al., Dictionary of Visual Science, 4th ed)
Antibodies produced by a single clone of cells.
Venous vessels in the umbilical cord. They carry oxygenated, nutrient-rich blood from the mother to the FETUS via the PLACENTA. In humans, there is normally one umbilical vein.
Polymorphic cells that form cartilage.
Cell surface protein-tyrosine kinase receptors for HEPATOCYTE GROWTH FACTOR. They consist of an extracellular alpha chain which is disulfide-linked to the transmembrane beta chain. The cytoplasmic portion contains the catalytic domain and sites critical for the regulation of kinase activity. Mutations of the gene for PROTO-ONCOGENE PROTEINS C-MET are associated with papillary renal carcinoma and other neoplasia.
Inorganic salts of phosphoric acid.
The species Oryctolagus cuniculus, in the family Leporidae, order LAGOMORPHA. Rabbits are born in burrows, furless, and with eyes and ears closed. In contrast with HARES, rabbits have 22 chromosome pairs.
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Agents and endogenous substances that antagonize or inhibit the development of new blood vessels.
The most common form of fibrillar collagen. It is a major constituent of bone (BONE AND BONES) and SKIN and consists of a heterotrimer of two alpha1(I) and one alpha2(I) chains.
A protein-serine-threonine kinase that is activated by PHOSPHORYLATION in response to GROWTH FACTORS or INSULIN. It plays a major role in cell metabolism, growth, and survival as a core component of SIGNAL TRANSDUCTION. Three isoforms have been described in mammalian cells.
The farthest or outermost projections of the body, such as the HAND and FOOT.
Diffusible gene products that act on homologous or heterologous molecules of viral or cellular DNA to regulate the expression of proteins.
Small double-stranded, non-protein coding RNAs (21-31 nucleotides) involved in GENE SILENCING functions, especially RNA INTERFERENCE (RNAi). Endogenously, siRNAs are generated from dsRNAs (RNA, DOUBLE-STRANDED) by the same ribonuclease, Dicer, that generates miRNAs (MICRORNAS). The perfect match of the siRNAs' antisense strand to their target RNAs mediates RNAi by siRNA-guided RNA cleavage. siRNAs fall into different classes including trans-acting siRNA (tasiRNA), repeat-associated RNA (rasiRNA), small-scan RNA (scnRNA), and Piwi protein-interacting RNA (piRNA) and have different specific gene silencing functions.
An extra-embryonic membranous sac derived from the YOLK SAC of REPTILES; BIRDS; and MAMMALS. It lies between two other extra-embryonic membranes, the AMNION and the CHORION. The allantois serves to store urinary wastes and mediate exchange of gas and nutrients for the developing embryo.

FGF8 induces formation of an ectopic isthmic organizer and isthmocerebellar development via a repressive effect on Otx2 expression. (1/3896)

Beads containing recombinant FGF8 (FGF8-beads) were implanted in the prospective caudal diencephalon or midbrain of chick embryos at stages 9-12. This induced the neuroepithelium rostral and caudal to the FGF8-bead to form two ectopic, mirror-image midbrains. Furthermore, cells in direct contact with the bead formed an outgrowth that protruded laterally from the neural tube. Tissue within such lateral outgrowths developed proximally into isthmic nuclei and distally into a cerebellum-like structure. These morphogenetic effects were apparently due to FGF8-mediated changes in gene expression in the vicinity of the bead, including a repressive effect on Otx2 and an inductive effect on En1, Fgf8 and Wnt1 expression. The ectopic Fgf8 and Wnt1 expression domains formed nearly complete concentric rings around the FGF8-bead, with the Wnt1 ring outermost. These observations suggest that FGF8 induces the formation of a ring-like ectopic signaling center (organizer) in the lateral wall of the brain, similar to the one that normally encircles the neural tube at the isthmic constriction, which is located at the boundary between the prospective midbrain and hindbrain. This ectopic isthmic organizer apparently sends long-range patterning signals both rostrally and caudally, resulting in the development of the two ectopic midbrains. Interestingly, our data suggest that these inductive signals spread readily in a caudal direction, but are inhibited from spreading rostrally across diencephalic neuromere boundaries. These results provide insights into the mechanism by which FGF8 induces an ectopic organizer and suggest that a negative feedback loop between Fgf8 and Otx2 plays a key role in patterning the midbrain and anterior hindbrain.  (+info)

Increased expression of fibroblast growth factor 8 in human breast cancer. (2/3896)

Fibroblast growth factor 8 (FGF8) is an important developmental protein which is oncogenic and able to cooperate with wnt-1 to produce mouse mammary carcinoma. The level of expression of FGF8 mRNA was measured in 68 breast cancers and 24 non-malignant breast tissues. Elevated levels of FGF8 mRNA were found in malignant compared to non-malignant breast tissues with significantly more malignant tissues expressing FGF8 (P=0.019) at significantly higher levels (P=0.031). In situ hybridization of breast cancer tissues and analysis of purified populations of normal epithelial cells and breast cancer cell lines showed that malignant epithelial cells expressed FGF8 mRNA at high levels compared to non-malignant epithelial and myoepithelial cells and fibroblasts. Although two of the receptors which FGF8 binds to (FGFR2-IIIc, FGFR3-IIIc) are not expressed in breast cancer cells, an autocrine activation loop is possible since expression of fibroblast growth factor receptor (FGFR) 4 and FGFR1 are retained in malignant epithelial cells. This is the first member of the FGF family to have increased expression in breast cancer and a potential autocrine role in its progression.  (+info)

Fibroblast growth factor-8 expression is regulated by intronic engrailed and Pbx1-binding sites. (3/3896)

Fibroblast growth factor-8 (FGF8) plays a critical role in vertebrate development and is expressed normally in temporally and spatially restricted regions of the vertebrate embryo. We now report on the identification of regions of Fgf8 important for its transcriptional regulation in murine ES cell-derived embryoid bodies. Stable transfection of ES cells, using a human growth hormone reporter gene, was employed to identify regions of the Fgf8 gene with promoter/enhancer activity. A 2-kilobase 5' region of Fgf8 was shown to contain promoter activity. A 0.8-kilobase fragment derived from the large intron of Fgf8 was found to enhance human growth hormone expressed from the Fgf8 promoter 3-4-fold in an orientation dependent manner. The intronic fragment contains DNA-binding sites for the AP2, Pbx1, and Engrailed transcription factors. Gel shift and Western blot experiments documented the presence of these transcription factors in nuclear extracts from ES cell embryoid bodies. In vitro mutagenesis of the Engrailed or Pbx1 site demonstrated that these sites modulate the activity of the intronic fragment. In addition, in vitro mutagenesis of both Engrailed and Pbx1 sites indicated that other unidentified sites are responsible for the transcriptional enhancement observed with the intronic fragment.  (+info)

Gap junction signalling mediated through connexin-43 is required for chick limb development. (4/3896)

During chick limb development the gap junction protein Connexin-43 (Cx43) is expressed in discrete spatially restricted domains in the apical ectodermal ridge (AER) and mesenchyme of the zone of polarising activity. Antisense oligonucleotides (ODNs) were used to investigate the role of Connexin-43 (Cx43) in the development of the chick limb bud. We have used unmodified ODNs in Pluronic F-127 gel, which is liquid at low temperature but sets at room temperature and so remains situated at the point of application. As a mild surfactant, the gel increases antisense ODN penetration and supplies ODNs to the embryo continually for 12-18 h. We have shown a strong decrease in Cx43 protein expression after application of specific antisense oligonucleotides but the abundance of a closely related protein, Connexin-32 (Cx32), was not affected. Application of antisense Cx43 ODNs at stages 8-15 HH before limb outgrowth resulted in dramatic limb phenotypes. About 40% of treated embryos exhibited defects such as truncation of the limb bud, fragmentation into two or more domains, or complete splitting of the limb bud into two or three branches. Molecular analysis of antisense treated embryos failed to detect Shh or Bmp-2 in anterior structures and suggested that extra lobes seen in nicked and split limbs were not a result of establishment of new signalling centres as found after the application of FGF to the flank. However, examination of markers for the AER showed a number of abnormalities. In severely truncated specimens we were unable to detect the expression of either Fgf-4 or Fgf-8. In both nicked and split limbs the expression of these genes was discontinuous. Down-regulation of Cx43 after the antisense application could be comparable to AER removal and results in distal truncation of the limb bud. Taken together these data suggest the existence of a feedback loop between the FGFs and signalling mediated by Cx43.  (+info)

derriere: a TGF-beta family member required for posterior development in Xenopus. (5/3896)

TGF-beta signaling plays a key role in induction of the Xenopus mesoderm and endoderm. Using a yeast-based selection scheme, we isolated derriere, a novel TGF-beta family member that is closely related to Vg1 and that is required for normal mesodermal patterning, particularly in posterior regions of the embryo. Unlike Vg1, derriere is expressed zygotically, with RNA localized to the future endoderm and mesoderm by late blastula, and to the posterior mesoderm by mid-gastrula. The derriere expression pattern appears to be identical to the zygotic expression domain of VegT (Xombi, Brat, Antipodean), and can be activated by VegT as well as fibroblast growth factor (FGF). In turn, derriere activates expression of itself, VegT and eFGF, suggesting that a regulatory loop exists between these genes. derriere is a potent mesoderm and endoderm inducer, acting in a dose-dependent fashion. When misexpressed ventrally, derriere induces a secondary axis lacking a head, an effect that is due to dorsalization of the ventral marginal zone. When misexpressed dorsally, derriere suppresses head formation. derriere can also posteriorize neurectoderm, but appears to do so indirectly. Together, these data suggest that derriere expression is compatible only with posterior fates. In order to assess the in vivo function of derriere, we constructed a dominant interfering Derriere protein (Cm-Derriere), which preferentially blocks Derriere activity relative to that of other TGFbeta family members. Cm-derriere expression in embryos leads to posterior truncation, including defects in blastopore lip formation, gastrulation and neural tube closure. Normal expression of anterior and hindbrain markers is observed; however, paraxial mesodermal gene expression is ablated. This phenotype can be rescued by wild-type derriere and by VegT. Our findings indicate that derriere plays a crucial role in mesodermal patterning and development of posterior regions in Xenopus.  (+info)

adrift, a novel bnl-induced Drosophila gene, required for tracheal pathfinding into the CNS. (6/3896)

Neurons and glial cells provide guidance cues for migrating neurons. We show here that migrating epithelial cells also contact specific neurons and glia during their pathfinding, and we describe the first gene required in the process. In wild-type Drosophila embryos, the ganglionic tracheal branch navigates a remarkably complex path along specific neural and glial substrata, switching substrata five times before reaching its ultimate target in the CNS. In adrift mutants, ganglionic branches migrate normally along the intersegmental nerve, but sporadically fail to switch to the segmental nerve and enter the CNS; they wind up meandering along the ventral epidermis instead. adrift encodes a novel nuclear protein with an evolutionarily conserved motif. The gene is required in the trachea and is expressed in the leading cells of migrating ganglionic branches where it is induced by the branchless FGF pathway. We propose that Adrift regulates expression of tracheal genes required for pathfinding on the segmental nerve, and FGF induction of adrift expression in migrating tracheal cells promotes the switch from the intersegmental to the segmental nerve.  (+info)

Nuclear matrix targeting of the protein kinase CK2 signal as a common downstream response to androgen or growth factor stimulation of prostate cancer cells. (7/3896)

Protein kinase CK2, a messenger-independent serine/threonine kinase, has been implicated in cell growth. Androgenic stimulus in rat prostate modulates its association with nuclear matrix (NM) and chromatin. Because the growth of human prostate carcinoma cells is influenced by androgens and/or growth factors, we determined the nature of CK2 signaling in the NM in response to androgen and growth factor stimuli. Androgen-sensitive LNCaP and androgen-insensitive PC-3 cells were cultured in media to regulate their growth in the presence of 5alpha-dihydrotestosterone (5alpha-DHT) or growth factors (epidermal growth factor, keratinocyte growth factor, and transforming growth factor alpha). The activity of CK2 was measured in the cytosolic and NM fractions isolated from these cells after treatment with growth stimuli. The changes in CK2 in various fractions were also confirmed by immunoblotting with a specific antibody. LNCaP cells responded to both 5alpha-DHT and growth factors for growth. The presence of these agents in the culture medium evoked a translocation of CK2 to the NM from the cytosol. The PC-3 cells did not respond to 5alpha-DHT for growth but did respond to growth factors. Under these conditions, there was also a translocation of CK2 to the NM concomitant with a decrease in the cytosolic fraction. These results suggest that CK2 translocation to the NM occurs in response to various growth stimuli in cells in culture. Thus, CK2 is a common downstream signal transducer in response to diverse growth stimuli that may relate to the pathobiology of prostate cancer cells.  (+info)

FGF8 functions in the specification of the right body side of the chick. (8/3896)

Left-right asymmetry in vertebrate embryos is first recognisable using molecular markers that encode secreted proteins or transcription factors. The asymmetry becomes morphologically obvious in the turning of the embryo and in the development of the heart, the gut and other visceral organs. In the chick embryo, a signalling pathway for the specification of the left body side was demonstrated. Here, Sonic hedgehog (Shh) protein is the first asymmetric signal identified in the node [1] [2]. Further downstream in this pathway are the left-specific genes nodal, lefty-1, lefty-2 and Pitx2 [1] [3] [4] [5]. On the right body side, a function of the activin pathway is indicated by the right-sided expression of cActRIIa [1] [6]. We detected that another key molecule in vertebrate development, fibroblast growth factor 8 (FGF8) [7] [8], is expressed asymmetrically on the right side of the posterior node. We demonstrate that transcription of FGF8 is induced by activin and the FGF8 protein inhibits the expression of nodal and Pitx2 and leads to expression of the chicken snail related gene (cSnR) [9]. Left-sided application of FGF8 randomises the direction of heart looping.  (+info)

Börjeson-Forssman-Lehmann syndrome (BFLS) is a syndromal X-linked mental retardation, which maps by linkage to the q26 region of the human X chromosome. We have identified a male patient with BFLS-lik
TY - JOUR. T1 - Evaluation of the tumorigenic and angiogenic potential of human fibroblast growth factor FGF3 in nude mice. AU - Li, J. J.. AU - Friedman-Kien, A. E.. AU - Cockerell, C.. AU - Nicolaides, A.. AU - Liang, S. L.. AU - Huang, Y. Q.. PY - 1998/6/13. Y1 - 1998/6/13. N2 - Recently, the expression of fibroblast growth factor 3 (FGF3) was found in 55% of human Kaposis sarcoma (KS) tumor tissues examined, while almost no expression of FGF3 was found in normal skin. To further these studies, human FGF3 cDNA were constructed by the overlap-extension method. The proteins translated from two FGF3 cDNA, which differ only in the sequences preceding the AUG presumed to be the initiation codon, were shown to have the same molecular mass. This result suggests that translation of human FGF3, which is different from mouse FGF3, begins only at the AUG site. The human FGF cDNA was transfected into NIH3T3 cells. The NIH 3T3 cells transformed by FGF3 were then injected subcutaneously into athymic nude ...
Plasma Fibroblast therapy is an elective, aesthetic, beauty procedure that can be offered as an alternative to laser, injections, and surgical therapies to tighten, rejuvenate. and improve the skins appearance.. Plasma Fibroblast therapy targets fibroblast cells. Fibroblasts are collagen and protein-producing cells in the dermis layer of skin which is just below your outermost skin layer. Fibroblasts play an important role in maintaining skin firmness and tightness, as well as, helping skin wounds heal.. Plasma Fibroblast therapy uses a pen-like device that discharges a high-frequency energy charge or arc. Your procedure will be performed using the Plamere™ Premium Plasma Pen (FDA registered). The plasma pens tip does not directly touch the skin, but instead releases a targeted arc just above the skins surface. This arc creates a tiny, micro-injury in the skins surface layer due to a reaction called sublimation.. ...
Great question. SHOP OUR PLASMA PEN FROM $1300 TO $1109. PLASMA PEN Certified Specialist. Plasma Fibroblast uses an electrical arch to burn off excess sagging skin whilst lifting and tightening the tissue to also remove fine lines and wrinkles. Almost gone. Oct 9, 2020 - Explore Melodys board PLASMA FIBROBLAST on Pinterest. The Plasma Doctor was created to give clients a clinic where they could be assured that treatments are only delivered by trained and insured practitioners. With this investment in your Fibroblast Plasma Pen training, you can make your money back and profit after the first procedure! The only cosmetic treatment that uses plasma to eliminate excess skin. - Expand your business. Fibroblast treatment is referred to as soft surgery because it delivers similar results as cosmetic surgery without the risk, cost, or recovery time. Something went wrong. Plasma Fibroblast has increased in popularity due to its many advantages over surgery. Plasma Skin Tightening uses a completely ...
Voltage-gated sodium channels (Nav) produce sodium currents that underlie the initiation and propagation of action potentials in nerve and muscle cells. Fibroblast growth factor homologous factors (FHFs) bind to the intracellular C-terminal region of the Nav subunit to modulate fast inactivation of the channel. In this study we solved the crystal structure of a 149-residue-long fragment of human FHF2A which unveils the structural features of the homology core domain of all 10 human FHF isoforms. Through analysis of crystal packing contacts and site-directed mutagenesis experiments we identified a conserved surface on the FHF core domain that mediates channel binding in vitro and in vivo. Mutations at this channel binding surface impaired the ability of FHFs to co-localize with Navs at the axon initial segment of hippocampal neurons. The mutations also disabled FHF modulation of voltage-dependent fast inactivation of sodium channels in neuronal cells. Based on our data, we propose that FHFs ...
TY - JOUR. T1 - Fibroblast growth factor 23, bone mineral density, and risk of hip fracture among older adults. T2 - The cardiovascular health study. AU - Jovanovich, Anna. AU - Bùžková, Petra. AU - Chonchol, Michel. AU - Robbins, John A. AU - Fink, Howard A.. AU - De Boer, Ian H.. AU - Kestenbaum, Bryan. AU - Katz, Ronit. AU - Carbone, Laura. AU - Lee, Jennifer. AU - Laughlin, Gail A.. AU - Mukamal, Kenneth J.. AU - Fried, Linda F.. AU - Shlipak, Michael G.. AU - Ix, Joachim H.. PY - 2013/8. Y1 - 2013/8. N2 - Context: Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone that also inhibits calcitriol synthesis. Objective: Our objective was to evaluate the relationships of plasma FGF23 concentrations with bone mineral density (BMD) and hip fracture in community-dwelling older adults. Design and Setting: Linear regression and Cox proportional hazard models were used to examine the associations of plasma FGF23 concentrations with BMD and incident hip fracture, respectively. Analyses ...
Experience the results you are looking for with the only cosmetic treatment that uses plasma to eliminate excess skin. The Plasma Lift treatment is low risk, downtime is minimal, and much more affordable than surgery. Plasma Fibroblast is especially known for its effectiveness as a Non-Surgical Eye Lift, Tummy Tightening, and reduction of Stretch Marks. Plamere Plasma fibroblast skin tightening treatment targets the loss of collagen and elasticity. This controlled wound to the skin activates the bodys own natural healing response. The dissipation of heat throughout the skin on the targeted area of your body sends fibroblasts to the area to start the process of anti aging. The stimulated fibroblasts lay down collagen and elastin fibers, which promotes plumping and tightening of the skin. This innovative technique cannot cause the so-called overlifting, as it only affects excess loose skin which returns to its original state. ...
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BACKGROUND While saturated fat intake leads to insulin resistance and nonalcoholic fatty liver, Mediterranean-like diets enriched in monounsaturated fatty acids (MUFA) may have beneficial effects. This study examined effects of MUFA on tissue-specific insulin sensitivity and energy metabolism.METHODS A randomized placebo-controlled cross-over study enrolled 16 glucose-tolerant volunteers to receive either oil (OIL, ~1.18 g/kg), rich in MUFA, or vehicle (VCL, water) on 2 occasions. Insulin sensitivity was assessed during preclamp and hyperinsulinemic-euglycemic clamp conditions. Ingestion of 2H2O/acetaminophen was combined with [6,6-2H2]glucose infusion and in vivo 13C/31P/1H/ex vivo 2H-magnet resonance spectroscopy to quantify hepatic glucose and energy fluxes.RESULTS OIL increased plasma triglycerides and oleic acid concentrations by 44% and 66% compared with VCL. Upon OIL intervention, preclamp hepatic and whole-body insulin sensitivity markedly decreased by 28% and 27%, respectively, along ...
Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating substance. Circulating FGF-23 levels increase markedly in dialysis patients and are independently associated with increased risk of mortality. Given the fact that cardiovascular disease is the leading cause of death in dialysis patients, the aim of this study was to test if elevated FGF-23 levels might be associated with left ventricular mass index (LVMI) and left ventricular index of myocardial performance (MPI) in maintenance haemodialysis patients.. Methods: In this cross-sectional study, plasma FGF-23 concentrations are measured using a C-terminal human enzyme-linked immunosorbent assay kit and echocardiography is performed in maintenance haemodialysis patients.. Serum FGF-23 levels will be measured in patients with a history of coronary artery disease and aortic valve calcifications.It will be searched whether patients with MPI,0.47 had higher or lower serum FGF-23 levels than those with MPI,0.47. Correlations will be examined ...
Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating substance. Circulating FGF-23 levels increase markedly in dialysis patients and are independently associated with increased risk of mortality. Given the fact that cardiovascular disease is the leading cause of death in dialysis patients, the aim of this study was to test if elevated FGF-23 levels might be associated with left ventricular mass index (LVMI) and left ventricular index of myocardial performance (MPI) in maintenance haemodialysis patients.. Methods: In this cross-sectional study, plasma FGF-23 concentrations are measured using a C-terminal human enzyme-linked immunosorbent assay kit and echocardiography is performed in maintenance haemodialysis patients.. Serum FGF-23 levels will be measured in patients with a history of coronary artery disease and aortic valve calcifications.It will be searched whether patients with MPI,0.47 had higher or lower serum FGF-23 levels than those with MPI,0.47. Correlations will be examined ...
Growth and lineage-specific differentiation constitute crucial phases in the development of stem cells. Control over these processes is exerted by particular elements of the extracellular matrix, which ultimately trigger a cascade of signals that regulate uncommitted cells, by modulating their survival and cell cycle progression, to shape developmental processes. Uncontrolled, constitutive activation of fibroblast growth factor receptors (FGFR) results in bone abnormalities, underlining the stringent control over fibroblast growth factor (FGF) activity that must be maintained for normal osteogenesis to proceed. Mounting evidence suggests that FGF signalling, together with a large number of other growth and adhesive factors, is controlled by the extracellular glycosaminoglycan sugar, heparan sulfate (HS). In this review, we focus on FGF activity during osteogenesis, their receptors, and the use of HS as a therapeutic adjuvant for bone repair. © 2006 Elsevier B.V. All rights reserved ...
Excessive fecal bile acid (BA) loss causes symptoms in a large proportion of people diagnosed with irritable bowel syndrome with diarrhea, a common functional bowel disorder. This BA diarrhea (BAD) results from increased hepatic synthesis of BAs, with impaired negative feedback regulation by the ileal hormone fibroblast growth factor 19 (FGF19). In this issue of the JCI, Zhao et al. investigated BA metabolism, including fecal BAs, serum BAs, and FGF19, in patients and controls. They identified associations between fecal bacterial BA metabolism and specific microbiota, especially Clostridium scindens. These findings have been tested in a mouse model using microbiota transplants and antibiotic treatment. This group of organisms has potential as a biomarker for BAD and to be a target for therapy.. ...
div class=citation vocab=http://schema.org/,,i class=fa fa-external-link-square fa-fw,,/i, Data from ,span resource=http://link.library.deakin.edu.au/portal/Structural-basis-for-Fibroblast-Growth-Factor/xb2AFUKUcsU/ typeof=CreativeWork http://bibfra.me/vocab/lite/Item,,span property=name http://bibfra.me/vocab/lite/label,,a href=http://link.library.deakin.edu.au/portal/Structural-basis-for-Fibroblast-Growth-Factor/xb2AFUKUcsU/,Structural basis for Fibroblast Growth Factor (FGF) receptor activation : implications in development and disease, Moosa Mohammadi, (electronic resource),/a,,/span, - ,span property=offers typeOf=Offer,,span property=offeredBy typeof=Library ll:Library resource=http://link.library.deakin.edu.au/#Deakin%20University%20Library,,span property=name http://bibfra.me/vocab/lite/label,,a property=url href=http://link.library.deakin.edu.au/,Deakin University Library,/a,,/span,,/span,,/span,,/span,,/div ...
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Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Fibroblast Growth Factor 6 (FGF6) in samples from Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids. with no significant corss-reactivity with analogues from other species ...
|strong|Recombinant Human FGF basic|/strong| represents the C-terminal protion of human fibroblast growth factor 2 (A|sup|135|/sup| - S|sup|288|/sup|).|br||br|Fibroblast growth factor basic (FGF basi…
Mouse anti Human FGF Basic antibody, clone MC-GF1 recognizes basic fibroblast growth factor (bFGF). Mouse anti Human FGF Basic antibody, c
Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. Integrins are involved in FGF signaling, since integrin antagonists suppress FGF signaling. This is called integrin-FGF crosstalk, while the specifics of the crosstalk are unclear. This review highlights recent findings that FGF1 directly interacts with integrin αvβ3, and the resulting integrin-FGF-fibroblast growth factor receptor (FGFR) ternary complex formation is essential for FGF1-induced cell proliferation, migration and angiogenesis. An integrin-binding defective FGF1 mutant (Arg-50 to Glu, R50E) is defective in ternary complex formation and in inducing cell proliferation, migration and angiogenesis, while R50E still binds to the FGF receptor and heparin. In addition, R50E suppressed tumorigenesis in vivo, while wild-type (WT) FGF1 enhanced it. Thus, the direct interaction between FGF1 and integrin αvβ3 is a potential therapeutic target, and R50E is a potential
The researchers from Yale University used X-ray crystallography, a technique that provides high-resolution, three-dimensional views of these proteins.. They revealed, first, beta-Klotho is the primary receptor that binds to FGF21, a key hormone produced upon starvation.. When bound to beta-Klotho, FGF21 stimulates insulin sensitivity and glucose metabolism, causing weight loss.. This new understanding of beta-Klotho and FGF21 can guide the development of therapies for conditions such as type-2 diabetes in obese patients, the researchers said.. Senior author Joseph Schlessinger said, Like insulin, FGF21 stimulates metabolism including glucose uptake.. The senior researcher also added that in animals and in some clinical trials of FGF21, it shows that you can increase burning of calories without changing food intake and we now understand how to improve the biological activity of FGF21.. The authors also describe a new variant of FGF21 has 10 times higher potency and cellular ...
Fibrocoblast growth factor (FGF) 15 in the mouse and its human orthologist FGF19 (set rated FGF15 / 19) are intestinal hormones that control the homeostasis of bile acids and glucose during the transition from the Fed to the Gamening state. In addition to its central role in the regulation of the biliary homeostasis, FGF15 / 19 is now recognized as a cross-cutting metabolic coordinator at the crossroads of the gut, liver, brain and adipose white tissue. The dysregulation of the signaling FGF15 / 19 can contribute to the pathogenesis of several diseases affecting the axis of the gut liver and metabolic diseases.. Here we provide an overview of the current knowledge of the physiological roles of the entockin FGF15 / 19 and to highlight the commonalities and differences between the two orthologists. We also discuss the putative therapeutic potential in areas of unmet medical needs - such as cholesatic liver diseases and non-alcoholic steatohepatitis, for which FGF19 is tested in current clinical ...
Fibroblast Growth Factor-1 Human Recombinant (FGF-1) produced in Sf9 insect cells is a single, glycosylated, polypeptide chain containing 140 amino acids and having a molecular mass of 15803 Dalton. The FGF-a is purified by proprietary chromatographic techniques.
Fgf6, a member of the Fibroblast Growth Factor (FGF) family, is developmentally regulated and its expression is highly restricted in the adult. To gain further insight into the role of Fgf6, we studied its expression during embryogenesis using RNA in situ hybridization. Fgf6 expression is restricted to developing skeletal muscle. Fgf6 transcripts are first detected in the somites at 9.5 days post-conceptus, and expression continues in developing skeletal muscles up to at least 16.5 days post-conceptus. Fgfr4 is a putative receptor for FGF6. Its pattern of expression during myogenesis overlaps that of Fgf6, but both genes are not expressed in exactly the same population of cells. In addition, recombinant FGF6 protein is able to repress the terminal differentiation of myoblasts in culture, providing additional support to the concept that FGF6 plays an important role in myogenesis.. ...
Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. To this end the precise role played by FGF21 in the biology of fasting has been the subject of several recent studies which have demonstrated contributions to the regulation of both lipid and carbohydrate metabolism. In the present study we compared wild type (WT) and FGF21 null (FGF21KO) mice, demonstrating that despite the significant induction of FGF21 during fasting in the WT animals, our strain of FGF21 null mice exhibit only limited impairments in their adaptation to nutrient deprivation. Specifically, fasted FGF21KO mice display a mild attenuation of gluconeogenic transcriptional induction in the liver accompanied by partially blunted glucose production in response to a pyruvate challenge. Furthermore, FGF21KO mice displayed only minor impairments in lipid metabolism in the fasted state, limited to accumulation of hepatic triglycerides and a reduction in expression of genes
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis ...
Review the roles of members of the FGF19 subclass of fibroblast growth factor (FGF) hormones in NAFLD and NASH, and the emerging NAFLD/NASH therapies targeting this endocrine axis.
FGF10 antibody (fibroblast growth factor 10) for ELISA, Neut, WB. Anti-FGF10 pAb (GTX12469) is tested in Human samples. 100% Ab-Assurance.
FGF1 antibody [4D2] (fibroblast growth factor 1 (acidic)) for ICC/IF, WB. Anti-FGF1 mAb (GTX84503) is tested in Human samples. 100% Ab-Assurance.
This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008 ...
Programmed cell death (PCD) in the interdigit region of developing vertebrate limbs generates separated rather than webbed digits. Previous models have proposed that bone morphogenetic proteins (BMPs) directly trigger such PCD; however, they might also act indirectly by regulating fibroblast growth factors (FGFs), which act as cell survival factors. To investigate this question, Mark Lewandoskis group inactivated the BMP receptor gene Bmpr1a specifically in the limb buds apical ectodermal ridge (AER) - a source of FGF activity. They report on p. 2359 that in mice, BMP signalling mediates AER induction. However, it subsequently inhibits the expression of the AER survival factors Fgf4 and Fgf8, leading to interdigit PCD. By generating conditional mutant mice, the authors show that Bmpr1a inactivation induces Fgf4 and Fgf8 upregulation in the AER. Webbing persists in mice where Bmpr1a and Fgf8 are inactivated, but disappears when one copy of Fgf4 is also inactivated. Evolutionary alterations in ...
Catalog No :RS01Ab0513 Organism- Human Clonality :Polyclonal Host :Rabbit Application :WB, ICC, IHC-P, IHC-F, ELISA Concentration : 200ug/ml UOM : 100ug Conjugate : No Conjugate Immunogen Information : Immunogen : Recombinant FGF1 (Met1~Asp155) expressed in E.coli. Antibody Specificity : The antibody is a rabbit polyc
Catalog No :RS01Ab0516 Organism- Rat Clonality :Polyclonal Host :Rabbit Application :WB, ICC, IHC-P, IHC-F, ELISA Concentration : 200ug/ml UOM : 100ug Conjugate : No Conjugate Immunogen Information : Immunogen : Recombinant FGF1 (Phe16~Asp155) expressed in E.coli. Antibody Specificity : The antibody is a rabbit polyc
During the procedure, tiny plasma flash also referred to as an electrical arc is being discharged from the tip of the handpiece. The tool itself never touches the skin however plasma flash creates a tiny dot upon the contact. This innovative technology uses the sublimation process, turning solid directly to gas to tighten skin tissue. Targeted tissue sublimate, causing no damage to surrounding areas or deeper skin layers.. Further points are applied to create a symmetrical grid over the treatment area. Effects are noticeable right away with full results become visible after 2-4 weeks. Patients can resume regular activities right away with minimal discomfort.. ...
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Our FDA approved Plamere Plasma Pen Pro is one of the first in the World to utilize a low frequency delivery of the plasma arc. This enables the treatment imprint to be wider, and shallower than traditional thermal only devices. The benefits of which are a greater tightening effect allowing for better results, a quicker healing process and less down time to the client. The plasma pen can be used on most skin types, however, your practitioner will assess your skin and offer a test patch prior to treatment.. ​. Does It Hurt ...
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Due to the growing demand for online purchases, the internet stores are now providing customers with a much wider selection the a list of the best E-shisha pen flavours out there . Instead of having to settle for the item in the brick and mortar store, you are now able to peruse a plethora of online options. Furthermore, a person can browse different sites at a single time comparing prices instantly to find the best deal from the most suitable vape shops.. Regardless of whether you vape or not, all people have had bad experiences with in your face sales assistants. By using online services, you will not have to deal with these individuals and can linger on the site for as long as you wish. While some websites will provide an automated chat pop-up this can be removed by clicking the X button. No pressure to buy makes the shopping experience far more pleasurable.. ...
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Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
References for Abcams Anti-FGF1 antibody - N-terminal (ab75928). Please let us know if you have used this product in your publication
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell …
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Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.[1] ... The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad ... cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was shown to be expressed in normal brain, ... Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ...
Fibroblast growth factor 15 is a protein in mouse encoded by the Fgf15 gene. It is a member of the fibroblast growth factor ( ... "Mouse FGF15 fibroblast growth factor 15". Jones SA (2012). Physiology of FGF15/19. Advances in Experimental Medicine and ... McWhirter JR, Goulding M, Weiner JA, Chun J, Murre C (Sep 1997). "A novel fibroblast growth factor gene expressed in the ... Potthoff MJ, Kliewer SA, Mangelsdorf DJ (Feb 2012). "Endocrine fibroblast growth factors 15/19 and 21: from feast to famine". ...
Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene. The protein encoded by this gene is a ... "Entrez Gene: Fibroblast growth factor 22". This article incorporates text from the United States National Library of Medicine, ... "Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family". The Journal of Biological ... member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, ...
Fibroblast growth factor 16 is a protein which in humans is encoded by the FGF16 gene. The protein encoded by this gene is a ... "Entrez Gene: Fibroblast growth factor 16". Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, ... on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148-52. doi:10.1006/bbrc ... member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, ...
"Fibroblast growth factor signalling in the hair growth cycle: expression of the fibroblast growth factor receptor and ligand ... "Fibroblast growth factor 5 proto-oncogene is expressed in normal human fibroblasts and induced by serum growth factors". ... "Vascular endothelial growth factor and fibroblast growth factor 5 are colocalized in vascular and avascular epiretinal ... Ota Y, Saitoh Y, Suzuki S, Ozawa K, Kawano M, Imamura T (January 2002). "Fibroblast growth factor 5 inhibits hair growth by ...
Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene. The protein encoded by this gene is a ... "Entrez Gene: FGF17 fibroblast growth factor 17". Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two ... Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J ... activity and expression of fibroblast growth factor 17". Mech. Dev. 83 (1-2): 165-78. doi:10.1016/S0925-4773(99)00034-9. PMID ...
Translokin binds basic fibroblast growth factor (FGF2; MIM 134920) and mediates its nuclear translocation and mitogenic ...
Hu MC, Wang YP, Qiu WR (1999). "Human fibroblast growth factor-18 stimulates fibroblast cell proliferation and is mapped to ... Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene. The protein encoded by this gene is a ... "Entrez Gene: FGF18 fibroblast growth factor 18". Davidson, D.; Blanc, A.; Filion, D.; Wang, H.; Plut, P.; Pfeffer, G.; ... FGF18 signals through fibroblast growth factor receptor FGFR3 to promote chondrogenesis and has been shown to cause thickening ...
"Entrez Gene: FGF6 fibroblast growth factor 6". Vainikka S, Partanen J, Bellosta P, et al. (1992). "Fibroblast growth factor ... Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene. The protein encoded by this gene is a ... 1989). "Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family". Oncogene. 4 ... Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J ...
September 2016). "Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast ... "The human gallbladder secretes fibroblast growth factor 19 into bile: towards defining the role of fibroblast growth factor 19 ... Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating ... "Entrez Gene: FGF19 fibroblast growth factor 19". Jones SA (2012). "Physiology of FGF15/19". Adv. Exp. Med. Biol. Advances in ...
"Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". ... Fibroblast growth factor 14 is a protein that in humans is encoded by the FGF14 gene. The protein encoded by this gene is a ... "Entrez Gene: FGF14 fibroblast growth factor 14". Wang Q, Bardgett ME, Wong M, et al. (2002). "Ataxia and paroxysmal dyskinesia ... 2006). "Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels". J. Physiol. 569 (Pt 1): ...
"Differential effects of fibroblast growth factor-4, epidermal growth factor and transforming growth factor-beta1 on functional ... effects of fibroblast growth factors on expression of genes of the plasminogen activator and insulin-like growth factor systems ... Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene. The protein encoded by this gene is a ... "Entrez Gene: FGF4 fibroblast growth factor 4 (heparin secretory transforming protein 1, Kaposi sarcoma oncogene)". Feldman B, ...
2003). "Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs". J. Biol. ... 2003). "Modulation of the cardiac sodium channel Nav1.5 by fibroblast growth factor homologous factor 1B". J. Biol. Chem. 278 ( ... Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins". Curr. ... "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". ...
Szebenyi G, Fallon JF (1999). "Fibroblast growth factors as multifunctional signaling factors". Int. Rev. Cytol. International ... It is well known that fibroblast growth factors (FGFs) bind heparin with relatively high affinity. HSPGs have also been shown ... Growth in culture and anchorage-independent growth were inhibited in SFRP1-expressing UMRC3 cells. The growth-inhibitory ... the key factor, vascular endothelial growth factor. The regulation of the EC cytoskeleton is critical to EC spreading and ...
2005). "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier ... 1999). "Fibroblast growth factor homologous factor 2 (FHF2): gene structure, expression and mapping to the Börjeson-Forssman- ... Schoorlemmer J, Goldfarb M (2003). "Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate ... Munoz-Sanjuan I, Smallwood PM, Nathans J (2000). "Isoform diversity among fibroblast growth factor homologous factors is ...
"Cellular signaling by fibroblast growth factor receptors". Cytokine & Growth Factor Reviews. 16 (2): 139-149. doi:10.1016/j. ... In mice, one gene known to regulate limb growth is prx1, which encodes a transcription factor. The expression patterns of prx1 ... De Luca F, Barnes KM, Uyeda JA, De-Levi S, Abad V, Palese T, Mericq V, Baron J (2001). "Regulation of growth plate ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ... transforming growth factor beta receptor binding. • growth factor activity. • transforming growth factor beta binding. • type ... type III transforming growth factor beta receptor binding. • cytokine activity. • type I transforming growth factor beta ... TGFB3, ARVD, ARVD1, RNHF, TGF-beta3, Transforming growth factor, beta 3, LDS5, transforming growth factor beta 3. ...
... insulin-like growth factor 1, human growth hormone, myostatin, vascular endothelial growth factor, fibroblast growth factor, ... The same is true of fibroblast growth factor. Glucagon-like peptide-1 increases the amount of glucose in the liver and has been ... Insulin-like growth factor 1 is a protein involved in the mediation of the growth hormone. Administration of IGF-1 to mice has ... created by administering a virus carrying the gene expressing insulin-like growth factor 1 to mice; the mice were stronger and ...
Fibroblast growth factor receptor oncogene partner 2 (FGFR1OP2) was identified in a study on myeloproliferative syndrome (EMS ... The protein encoded by the FGFR1 gene belongs to the fibroblast growth factor receptor family. FGFRs usually contain an ... FGFR1OP2, when fused with the fibroblast growth factor receptor 1 (FGFR1), is shown to cause myeloproliferative syndrome. ... Ornitz, DM; Xu (1996). "Receptor specificity of the fibroblast growth factor family". Journal of Biological Chemistry. 271 (25 ...
... and in fibroblast growth factors 1 and 2. CATH Architecture "Beta Trefoil" Murzin AG, Lesk AM, Chothia C (Jan 1992). "β-trefoil ... patterns of structure and sequence in the kunitz inhibitors interleukins-1β and 1α and fibroblast growth factors". Journal of ...
"Role of fibroblast growth factor 8 in growth and progression of hormonal cancer". Cytokine & Growth Factor Reviews. 18 (3-4): ... May 2001). "Enhanced invasion and tumor growth of fibroblast growth factor 8b-overexpressing MCF-7 human breast cancer cells". ... Fibroblast growth factor 8 is a protein that in humans is encoded by the FGF8 gene. The protein encoded by this gene is a ... "Entrez Gene: FGF8 fibroblast growth factor 8 (androgen-induced)". Harris WA, Sanes DH, Reh TA (2011). Development of the ...
Ligands that bind to RTKs include fibroblast growth factors, epidermal growth factors, platelet-derived growth factors, and ... Growth and differentiation factors (GDFs) Growth factor and clotting factors are paracrine signaling agents. The local action ... fibroblast growth factor (FGF) family, Hedgehog family, Wnt family, and TGF-β superfamily. Binding of a paracrine factor to its ... In addition to RTK pathway, fibroblast growth factors can also activate the JAK-STAT signaling pathway. Instead of carrying ...
"Entrez Gene: FGF21 fibroblast growth factor 21". BonDurant LD, Potthoff MJ (May 2018). "Fibroblast Growth Factor 21: A ... Fibroblast growth factor 21 is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a ... Yan H, Xia M, Chang X, Xu Q, Bian H, Zeng M, Rao S, Yao X, Tu Y, Jia W, Gao X (2011). "Circulating fibroblast growth factor 21 ... fibroblast+growth+factor+21 at the US National Library of Medicine Medical Subject Headings (MeSH) "FGF21". Information ...
... including several growth factors e.g. VEGF, FGF. The fibroblast growth factor (FGF) family with its prototype members FGF-1 ( ... by secreting various growth factors (e.g. VEGF) and proteins. Growth factors such as bFGF and VEGF can induce capillary growth ... "Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord ... this fact distinguishes FGF-1 from other pro-angiogenic growth factors, such as vascular endothelial growth factor (VEGF), ...
Secretion of fibroblast growth factor 23 requires O-glycosylation". J. Biol. Chem. 281 (27): 18370-7. doi:10.1074/jbc. ... 2007). "Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas ...
Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ... These regions of the brain are determined by a combination of transcription factors and the signals that change their ...
Schoorlemmer J, Goldfarb M (2003). "Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate ... Schoorlemmer J, Goldfarb M (2001). "Fibroblast growth factor homologous factors are intracellular signaling proteins". Curr. ... Buchsbaum RJ, Connolly BA, Feig LA (2002). "Interaction of Rac Exchange Factors Tiam1 and Ras-GRF1 with a Scaffold for the p38 ...
The binding of certain fibroblast growth factors (FGF's, viz., FGF19 and FGF21) to their fibroblast growth factor receptors, is ... Mice lacking either fibroblast growth factor 23 or the α-klotho enzyme display premature aging due to hyperphosphatemia. Many ... Prié D, Ureña Torres P, Friedlander G (May 2009). "[Fibroblast Growth Factor 23-Klotho: a new axis of phosphate balance control ... Kurosu H, Kuro-o M (Jul 2008). "The Klotho gene family and the endocrine fibroblast growth factors". Current Opinion in ...
"Fibroblast growth factor receptor substrate 2 participates in vascular endothelial growth factor-induced signaling". FASEB J. ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor ... Fibroblast growth factor receptor substrate 2 is a protein that in humans is encoded by the FRS2 gene. FRS2 is an 80 kDa ...
Fibroblast growth factor and fibroblast growth factor receptors regulate fetal bone growth and are expressed in cranial sutures ... The condition is associated with syndromes caused by mutations in fibroblast growth factor receptor genes (FGFR), including ... These last two are both important factors influencing bone development.[27]. Environmental factorsEdit. Environmental factors ... likely through effects on fibroblast growth factor receptor genes.[28][29][30][31][32] ...
Koon HW, Zhao D, Na X, Moyer MP, Pothoulakis C (Oct 2004). "Metalloproteinases and transforming growth factor-alpha mediate ... fibroblasts, stem cells, white blood cells) in many tissues and organs. SP amplifies or excites most cellular processes.[15][16 ... and epidermal growth factor. Because these regions are related to complexed signal transduction pathways mediated by cytokines ... "Neurotrophic and anhidrotic keratopathy treated with substance P and insulinlike growth factor 1". Archives of Ophthalmology. ...
Decreased ribosomal S6 kinase activity in cultured fibroblast or transformed lymphoblast cells from a male indicates Coffin- ... disorder that is X-linked dominant and which causes severe mental problems sometimes associated with abnormalities of growth, ... Guanine nucleotide exchange factor. *Marinesco-Sjögren syndrome. *Aarskog-Scott syndrome. *Juvenile primary lateral sclerosis ...
The growth of cervical loop cells into the deeper tissues forms Hertwig's Epithelial Root Sheath, which determines the root ... It is widely accepted that there is a factor within the tissues of the first branchial arch that is necessary for the ... Fibroblasts develop the periodontal ligaments which connect teeth to the alveolar bone through cementum.[4] ... and fibroblasts. Cementoblasts form the cementum of a tooth. Osteoblasts give rise to the alveolar bone around the roots of ...
Indeed, Rho-dependent response is stimulated by the action of growth factors on Rac protein.[8] ... Alan Hall showed the specificity of Rho in the stimulation of focal adhesions and stress fibres formation in fibroblasts in the ... The inhibition of endogenous Rac function by mutants N17rac and V12rac1 prevented growth factor-induced membrane ruffling. In ... "The small GTP-binding protein rac regulates growth factor-induced membrane ruffling". Cell. 70 (3): 401-410. doi:10.1016/0092- ...
A definitive diagnosis of Hunter syndrome is made by measuring I2S activity in serum, white blood cells, or fibroblasts from ... The age at onset of symptoms and the presence/absence of behavioral disturbances are predictive factors of ultimate disease ... growth and development, communication within the body, and protection from infection. Another critical function is the ...
Gene expression profiling revealed the prevalence of specific fibroblast growth factors (FGFs) and FGF receptors in NSCLC cell ... One approach used by tumors to upregulate growth and survival is through autocrine production of growth and survival factors. ... "Fibroblast Growth Factor (FGF) and FGF Receptor-Mediated Autocrine Signaling in Non-Small-Cell Lung Cancer Cells". Molecular ... For example, despite widespread expression of epidermal growth factor receptors (EGFRs) and EGF family ligands in non-small- ...
Stanley N. Cohen; Annie C. Y. Chang (1 May 1973). "Recircularization and Autonomous Replication of a Sheared R-Factor DNA ... Hershey, AD; Chase, M (1952). "Independent functions of viral protein and nucleic acid in growth of bacteriophage". The Journal ... "Three-Dimensional Maps of All Chromosomes in Human Male Fibroblast Nuclei and Prometaphase Rosettes". PLoS Biology 3 (5): e157 ...
Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human ... human fibroblasts. „Cell Death Differ". 5, s. 1062-1075, 1998. ... Negative regulation of cell growth and differentiation by ... Yu P, Huang B, Shen M, Lau C, Chan E, Michel J, Xiong Y, Payan DG, Luo Y. p15(PAF), a novel PCNA associated factor with ... Interaction of CR6 (GADD45gamma ) with proliferating cell nuclear antigen impedes negative growth control. „J. Biol. Chem.". ...
Cytokine Growth Factor Rev. 14 (2): 155-74. PMID 12651226. doi:10.1016/S1359-6101(03)00002-9. ... fibroblast, pluća, mijelo-monocitne ćelije, i stromalne ćelije koštane srži.[4][16][17] ... "Transforming growth factor-beta induces development of the T(H)17 lineage". Nature 441 (7090): 231-4. PMID 16648837. doi: ...
... growth factors, neurotrophic factors, anti-inflammatory drugs, antioxidants, anti-apoptotic drugs, and drugs to improve ... can be used to convert skin fibroblasts into motor neurons.[11] It is now possible to generate iPSCs from people with ALS, ... genetic factors and environmental factors are thought to be of roughly equal importance.[13] The genetic factors are better ... Environmental factors[edit]. Where no family history of the disease is present - around 90% of cases - no cause is known. ...
Calabretta B، Battini R، Kaczmarek L، de Riel JK، Baserga R (1986). "Molecular cloning of the cDNA for a growth factor- ... positive regulation of fibroblast proliferation. • ion transmembrane transport. • توصيل الإشارة. المصادر:Amigo / QuickGO. ... "Structural and functional analysis of a growth-regulated gene, the human calcyclin". J. Biol. Chem. 262 (17): 8325-32. PMID ...
It has also been shown that fibroblast growth factor (FGF) activates a signaling pathway that positively regulates the PDGF ... Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... "Vascular endothelial growth factor B, a novel growth factor for endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2567- ... Other growth factors in this family include vascular endothelial growth factors B and C (VEGF-B, VEGF-C)[16][17] which are ...
transcription factor complex. • bicellular tight junction. • nucleoplasm. • nucleolus. • perinuclear region of cytoplasm. • ... positive regulation of fibroblast proliferation. • response to hyperoxia. • positive regulation of translation. • regulation of ... 1995). "Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb ... Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y (1994). "Growth suppression by p18, a p16INK4/MTS1 ...
Clark IA (June-August 2007). "How TNF was recognized as a key mechanism of disease". Cytokine Growth Factor Rev. 18 (3-4): 335- ... fibroblasts, and neurons.[5] Large amounts of TNF are released in response to lipopolysaccharide, other bacterial products, and ... TNF, DIF, TNF-alpha, TNFA, TNFSF2, Tumour necrosis factor, TNF-α, tumor necrosis factor, TNLG1F, Tumor necrosis factor alpha. ... Tumor necrosis factor (TNF, tumor necrosis factor alpha, TNFα, cachexin, or cachectin) is a cell signaling protein (cytokine) ...
M344 is a benzamide that shows promising results in fibroblast cell culture and increases level of splicing factors known to ... a brain-derived neurotrophic factor that function in nerve growth and maintenance within the brain.[86][20]. *Vorinostat (SAHA) ... a neurotrophic factor important for long-term memory.[66] Expression of CREB, an activity-dependent transcription factor ... IL-6 and transforming growth factor-alpha levels are elevated in ventricular cerebrospinal fluid in juvenile parkinsonism and ...
Fibroblast. .mw-parser-output .nobold{font-weight:normal}. FGF receptor ligands:. *FGF1/FGF2/FGF5 ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults."[5] ... A major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in adults. ... It is believed to be a major fetal growth factor in contrast to Insulin-like growth factor 1, which is a major growth factor in ...
... resulting in accumulation of the ligase substrates and downregulation of fibroblast growth factor 8 (FGF8) and FGF10. This ... or the growth of new blood vessels has been reported to correspond with MM progression where vascular endothelial growth factor ... Thalidomide was discovered to inhibit tumour necrosis factor-alpha (TNF-α) in 1991. TNF-α is a cytokine produced by macrophages ... disrupts the positive feedback loop between the two growth factors, possibly causing both multiple birth defects and anti- ...
"Cytokine & Growth Factor Reviews. 22 (2): 99-108. doi:10.1016/j.cytogfr.2011.04.001. PMC 3994286. PMID 21531164.. ... Although IL-15 mRNA can be found in many cells and tissues including mast cells, cancer cells or fibroblasts, this cytokine is ... IL-15 was discovered in 1994 by two different laboratories, and characterized as T cell growth factor.[5] Together with ... Growth Factor Reviews. 22 (1): 19-33. doi:10.1016/j.cytogfr.2010.09.003. PMID 21074481.. ...
Platelet-Derived Growth Factor Receptor), and PDGFR β. Unlike most RTK inhibitors, crenolanib is a type I mutant-specific ... In stromal fibroblasts, PDGFRα activation leads to local tissue invasion, production and secretion of VEGF, and elevated ... a Highly Specific Platelet-Derived Growth Factor Receptor Tyrosine Kinase Inhibitor in Patients with Advanced Cancers". Journal ... The majority of these mutations result in constitutive activation of downstream signaling pathways and aberrant cell growth. ...
Growth factors. *Epidermal growth factor. *Fibroblast growth factor. *Nerve growth factor. *Platelet-derived growth factor ... Additional growth factors: Adrenomedullin. *Colony-stimulating factors (see here instead). *Connective tissue growth factor ( ... Hepatoma-derived growth factor (HDGF). *Interleukins/T-cell growth factors (see here instead) ...
Responses and Resistance to Transforming Growth Factor-β₁-Driven Myofibroblast Differentiation in Oral Mucosal Fibroblasts". ... Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is ... Nakamura T (1992). "Structure and function of hepatocyte growth factor". Progress in Growth Factor Research. 3 (1): 67-85. doi: ... "Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)".. *^ Yang ZJ, Zhang YR, Chen B, Zhang SL, Jia EZ, ...
Typically, age and lifestyle help determine the type of graft used for ACL reconstruction.[12] The biggest factors in knee ... Scaffolds that are used for ACL growth include collagen, silk, gelatin, polylactic acid, and glycosaminoglycans.[17] Mechanical ... Ligament tissue mainly consists of fibroblasts and extracellular matrix. Ligament cells differ in size, respond to different ... Cohen SB, Yucha DT, Ciccotti MC, Goldstein DT, Ciccotti MA, Ciccotti MG (September 2009). "Factors affecting patient selection ...
"Growth control of lung cancer by interruption of 5-lipoxygenase-mediated growth factor signaling". The Journal of Clinical ... Fibroblasts, smooth muscle cells and endothelial cells express low levels of ALOX5.[6][7] Up-regulation of ALOX5 may occur ... potent chemotactic factor, LTB4, and possibly also weaker chemotactic factor, 5S-HETE, which serve to attract and otherwise ... "Competitive binding assay of src homology domain 3 interactions between 5-lipoxygenase and growth factor receptor binding ...
"Rapamycin potentiates transforming growth factor beta-induced growth arrest in nontransformed, oncogene-transformed, and human ... positive regulation of fibroblast proliferation. • replicative senescence. • response to hyperoxia. • response to ... negative regulation of cell growth. • cell cycle arrest. • response to organonitrogen compound. • animal organ regeneration. • ... Tokumoto M, Tsuruya K, Fukuda K, Kanai H, Kuroki S, Hirakata H, Iida M (2003). "Parathyroid cell growth in patients with ...
... epidermal growth factor (EGF), IGF-1, and fibroblast growth factor (FGF), which in turn have specific roles in breast growth ... tumor necrosis factor β (TNF-β), transforming growth factor α (TGF-α),[67] transforming growth factor β (TGF-β),[68] heregulin, ... "Mitogenic properties of insulin-like growth factors I and II, insulin-like growth factor binding protein-3 and epidermal growth ... insulin-like growth factor 1 (IGF-1), and prolactin.[1] These regulators induce the expression of growth factors, such as ...
AAV encoding neurotrophic factors such as fibroblast growth factor (FGF) family members and GDNF either protected ... such as vascular endothelial growth factor (VEGF) and inhibitors of angiogenesis, such as pigment epithelium-derived factor ( ... Neurotrophic factors have the ability to modulate neuronal growth during development to maintain existing cells and to allow ... Since the regulation of vascularization in the mature retina involves a balance between endogenous positive growth factors, ...
... transforming growth factors alpha,[26] beta 1 and beta 2,[27][28] fibroblast growth factors,[29] epidermal growth factor,[30] ... granulocyte-macrophage-stimulating growth factor,[31] platelet-derived growth factor,[31] vascular endothelial growth factor,[ ... 1997). "Identification and partial purification of a basic fibroblast growth factor-like growth factor derived from bovine ... Colostrum also contains a number of growth factors, such as insulin-like growth factors I (IGF-1),[24] and II,[25] ...
Production of cytokines such as fibroblast growth factor by the abnormal hematopoietic cell clone (particularly by ... The V617F mutation appears to make hematopoietic cells more sensitive to growth factors that need JAK2 for signal transduction ... However, the proliferation of fibroblasts and deposition of collagen is a secondary phenomenon, and the fibroblasts themselves ... The abnormal megakaryocytes stimulate other cells, the fibroblasts, to produce collagen in the bone marrow,[9] by secreting ...
A dermatofibroma, or benign fibrous histiocytomas, is a benign skin growth.[3] ... Comparison with factor XIIIa and CD34". British Journal of Dermatology. 157 (2): 319-24. doi:10.1111/j.1365-2133.2007.08033.x. ... They are composed of disordered collagen laid down by fibroblasts. Dermatofibromas are classed as benign skin lesions, meaning ...
Fibrbroblast Growth Factor (FGF) signalling has lagged behind other receptor tyrosine kinases as a cancer therapeutic target, ... FGF, fibroblast growth factor; FGFR, FGF receptor; NA, not applicable; PDGFR, platelet-derived growth factor receptor; VEGFR ... The fibroblast growth factor (FGF) family nomenclature describes 23 members, although there are only 18 FGF receptor (FGFR) ... Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular ...
... epidermal growth factor, platelet-derived growth factor, and fibroblast growth factor. Cancer Res48 :4266 -4271,1988. ... Effects of epidermal growth factor (EGF), platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) on human ... cell growth factor beta is the precursor of both endothelial cell growth factor alpha and acidic fibroblast growth factor. Proc ... Subsequent analysis identified fibroblast growth factor (FGF)-1 as an adipogenic factor produced by MVECs. Expression of FGF-1 ...
These formulations provide a stabilized basic fibroblast growth factor (bFGF) which is less susceptible to oxidation or met ... 1. A stabilized basic fibroblast growth factor pharmaceutical formulation consisting essentially of a basic fibroblast growth ... Isolation of fibroblast growth factor. 1990-02-20. Gospodarowicz. 530/412. 4900730. Preparation which promotes the absorption ... Basic fibroblast growth factor (bFGF) is currently undergoing clinical trials for wound healing indications. Although early ...
An isolated DNA sequence encoding an angiogenic factor protein consisting of a single-polypeptide-chain protein having at least ... Gospodarowicz et al., "Fibroblast Growth Factor in Human Placenta", Biochem. Biophys. Res. Comm. (4/30/85). Moscatelli et al ... It has been shown that bovine kidney fibroblast growth factor (FGF) lacks a number of amino acids from the N-terminus (Baird, A ... Ordering of all the amino acid sequences listed above leads to a core sequence for the human basic fibroblast growth factor as ...
... we performed quantitative immunohistochemistry for MC tryptase and for basic fibroblast growth factor (bFGF) in lung tissue ... we performed quantitative immunohistochemistry for MC tryptase and for basic fibroblast growth factor (bFGF) in lung tissue ... To investigate the role of mast cells (MC) and their fibrogenic growth factors in silicosis, ... and their fibrogenic growth factors in silicosis, ...
Fibroblast growth factor 1 (FGF1) Fibroblast growth factor 2 (FGF2) Fibroblast growth factor 3 (FGF3) Fibroblast growth factor ... Fibroblast growth factor 5 (FGF5) Fibroblast growth factor 6 (FGF6) Fibroblast growth factor 7(FGF7) Fibroblast growth factor 8 ... Fibroblast growth factor 9 (FGF9) Fibroblast growth factor 10 (FGF10) Fibroblast growth factor 11 (FGF11) Fibroblast growth ... Fibroblast growth factor 13 (FGF13) Fibroblast growth factor 14 (FGF14) Fibroblast growth factor 15 (FGF15) Fibroblast growth ...
Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. FGF23 is a member of the ... "Entrez Gene: FGF23 fibroblast growth factor 23". Huang CL (May 2010). "Regulation of ion channels by secreted Klotho: ... January 2003). "Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25- ... Fukagawa M, Nii-Kono T, Kazama JJ (July 2005). "Role of fibroblast growth factor 23 in health and in chronic kidney disease". ...
... fibroblast growth factors include Engineering a Bilayered Hydrogel to Control ASC Differentiation, Rapid Detection of ... Application of Impermeable Barriers Combined with Candidate Factor Soaked Beads to Study Inductive Signals in the Chick, ... Fibroblast Growth Factors: A family of small polypeptide growth factors that share several common features including a strong ... stimulate the growth of fibroblasts this distinction is no longer a requirement for membership in the fibroblast growth factor ...
Fibroblast growth factor 2. Details. Name. Fibroblast growth factor 2. Kind. protein. Organism. Human. Polypeptides. Name. ... Fibroblast growth factor 2. P09038. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ...
Fibroblast growth factor 1. Details. Name. Fibroblast growth factor 1. Kind. protein. Organism. Human. Polypeptides. Name. ... Fibroblast growth factor 1. P05230. Details. Drug Relations. Drug Relations. DrugBank ID. Name. Drug group. Pharmacological ... Foreskin fibroblast (neonatal). approved. unknown. agonist. Details. DB10772. Foreskin keratinocyte (neonatal). approved. yes. ...
Fibroblast Growth Factor Receptor Signaling Crosstalk in Skeletogenesis Message Subject. (Your Name) has forwarded a page to ... such as those mediated by the epidermal growth factor receptor and platelet-derived growth factor receptor α, were associated ... Fibroblast growth factors (FGFs) play important roles in the control of embryonic and postnatal skeletal development by ... Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias. ...
... fibroblast growth factor 9 include Using Micro-computed Tomography for the Assessment of Tumor Development and Follow-up of ... Fibroblast Growth Factor 9: A fibroblast growth factor that was originally identified as a mitogen for Glial cells. It is ...
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the ... The second and third Ig-like domains directly interact with fibroblast growth factors (FGF) and heparan sulfate proteoglycans. ... Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. ...
"Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a ... Basic Fibroblast Growth Factor-Anchored Multilayered Mesenchymal Cell Sheets Accelerate Periosteal Bone Formation. Kentaro ... S. H. Bhang, Y. E. Lee, S.-W. Cho et al., "Basic fibroblast growth factor promotes bone marrow stromal cell transplantation- ... H. Schliephake, F. W. Neukam, A. Löhr, and D. Hutmacher, "The use of basic fibroblast growth factor (bFGF) for enhancement of ...
The exogenous application of growth factors, particularly basic fibroblast growth factor (bFGF), has been shown to promote ... fused to basic fibroblast growth factor (bFGF; bFGF-PKD-CBD) had greater skin fibroblast growth-promoting effects in nude mice ... "Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a ... Basic Fibroblast Growth Factor-Anchored Multilayered Mesenchymal Cell Sheets Accelerate Periosteal Bone Formation. Kentaro ...
Fibroblast growth factor receptor 3. Fibroblast growth factor receptor 3, FGFR-3, EC 2.7.10.1 (Heparin-binding growth factor ... Fibroblast growth factor receptor subfamily.UniRule annotation. Automatic assertion according to rulesi ... Fibroblast growth factor receptorUniRule annotation. Automatic assertion according to rulesi ... Fibroblast growth factor receptorSequence analysis. Automatic assertion according to rulesi ...
View mouse Fgf10 Chr13:118669791-118792115 with: phenotypes, sequences, polymorphisms, proteins, references, function, expression
J:41070 Smallwood PM, et al., Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in ...
"Fibroblast growth factor homologous factors are intracellular signaling proteins.". Schoorlemmer J., Goldfarb M.. Curr. Biol. ... "Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts.". Wang C., ... "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of ... "Fibroblast growth factor homologous factor 2B: association with Nav1.6 and selective colocalization at nodes of Ranvier of ...
The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which ... The mammalian fibroblast growth factors (FGFs) (FGF1-FGF23) constitute a large family of structurally related ligands that are ... Abbreviations: FGF, fibroblast growth factor; FGFR, FGF receptor; RCS, rat chondrosarcoma; SPR, surface plasmon resonance. ... Insights into the molecular basis for fibroblast growth factor receptor autoinhibition and ligand-binding promiscuity. Shaun K ...
Fibroblast growth factor receptor 3 is a negative regulator of bone growth.. Deng C1, Wynshaw-Boris A, Zhou F, Kuo A, Leder P. ... We have identified a role for fibroblast growth factor receptor 3 (FGFR-3) in this process by disrupting the murine Fgfr-3 gene ... Fibroblast Growth Factor, Type 3. *Receptors, Fibroblast Growth Factor/genetics*. *Receptors, Fibroblast Growth Factor/ ... This growth is accompanied by expansion of proliferating and hypertrophic chondrocytes within the cartilaginous growth plate. ...
... including fibroblast growth factor 4 (Fgf4). Here, we show that Fgf4 expression is induced by the transforming growth factor β- ... Abbreviations: Fgf4, fibroblast growth factor 4; ExE, extraembryonic ectoderm; EPC, ectoplacental cone; SPC, subtilisin-like ... Nodal protein processing and fibroblast growth factor 4 synergize to maintain a trophoblast stem cell microenvironment. Marcela ... A critical component of this microenvironment is fibroblast growth factor 4 (Fgf4), but additional, unknown signals are also ...
The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer ... Inhibition of fibroblast growth factor/fibroblast growth factor receptor activity in glioma cells impedes tumor growth by both ... Fibroblast growth factor/fibroblast growth factor receptor system in angiogenesis. Cytokine Growth F R. 2005;16:159-78. ... C11, a novel fibroblast growth factor receptor 1 (FGFR1) inhibitor, suppresses breast cancer metastasis and angiogenesis. *Zhuo ...
... cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this gene has not yet been determined. ... The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad ... Fgf11 (fibroblast growth factor 11). NCBI. Ortholog. Canis lupus familiaris (dog):. FGF11 (fibroblast growth factor 11). HGNC. ... Fgf11 (fibroblast growth factor 11). NCBI. Ortholog. Sus scrofa (pig):. FGF11 (fibroblast growth factor 11). HGNC. Ensembl, ...
Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but ... Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family. Miyake, A., Konishi, M., Martin, F. ... Fibroblast growth factor 16 and 18 are expressed in human cardiovascular tissues and induce on endothelial cells migration but ... Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family [1]. ...
... fibroblast growth factor 1 (acidic)), Authors: Seiji Mori, Yoshikazu Takada. Published in: Atlas Genet Cytogenet Oncol Haematol ... growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor ... growth factor receptor signaling pathway fibroblast growth factor receptor signaling pathway fibroblast growth factor receptor ... Expression of acidic fibroblast growth factor (aFGF) and fibroblast growth factor receptor 4 (FGFR4) in breast fibroadenomas.. ...
fibroblast growth factor 16 , fibroblast growh factor 16 , fibroblast growth factor 16-like , FGF-16 ... anti-Fibroblast Growth Factor 16 (FGF16) Antikörper. Bezeichnung:. anti-Fibroblast Growth Factor 16 Antikörper (FGF16). Auf www ... anti-Fibroblast Growth Factor 1 (Acidic) Antikörper * anti-Fibroblast Growth Factor (Acidic) Intracellular Binding Protein ... Weitere Antikörper gegen Fibroblast Growth Factor 16 Interaktionspartner. Zebrafish Fibroblast Growth Factor 16 (FGF16) ...
Keratinocyte growth factor decreases pulmonary edema, transforming growth factor-beta and platelet-derived growth factor-BB ... Synonyms: FGF-7, Fgf-7, Fibroblast growth factor 7, HBGF-7, Heparin-binding growth factor 7, ... ... Keratinocyte growth factor is a growth factor for type II pneumocytes in vivo. Ulich, T.R., Yi, E.S., Longmuir, K., Yin, S., ... the effects of heparin and glypican-1 on the bioactivity of acidic fibroblast growth factor and the keratinocyte growth factor. ...
Fibroblast growth factor signaling regulates growth and morphogenesis at multiple steps during brain development.. Vaccarino FM ... The fibroblast growth factor (FGF) family comprises several members with distinct patterns of expression in the developing ... The role of FGF2 in the growth and morphogenesis of the cerebral cortex is reviewed in detail. The cellular and molecular ... FGFs regulate the early specification and the subsequent growth of central nervous system regions. These different actions ...
Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon. L Robel, M Ding, AJ James ... Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon ... Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon ... Fibroblast growth factor 2 increases Otx2 expression in precursor cells from mammalian telencephalon ...
  • Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the FGFs. (wikipedia.org)
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)
  • FGFs initiate fibroblast proliferation. (everything2.com)
  • Fibroblast growth factors (FGFs) and their receptors control a wide range of biological functions, regulating cellular proliferation, survival, migration and differentiation. (medscape.com)
  • Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate fundamental developmental pathways, controlling events such as mesoderm patterning in the early embryo [ 1 ] through to the development of multiple organ systems. (medscape.com)
  • Fibroblast growth factors (FGFs) play important roles in the control of embryonic and postnatal skeletal development by activating signaling through FGF receptors (FGFRs). (sciencemag.org)
  • Affinity for fibroblast growth factors (FGFs) is increased by heparan sulfate glycosaminoglycans that function as coreceptors. (rcsb.org)
  • The mammalian fibroblast growth factors (FGFs) (FGF1-FGF23) constitute a large family of structurally related ligands that are involved in a multitude of biological processes from embryogenesis to adult homeostasis ( 1 ). (pnas.org)
  • Left ventricular hypertrophy and coronary artery calcification are potent risk factors for mortality in CKD, and FGFs have been implicated in the pathogenesis of both myocardial hypertrophy and atherosclerosis. (ahajournals.org)
  • The fibroblast growth factors (FGFs) act via four receptor tyrosine kinases (FGF receptors (FGFRs)) to elicit diverse physiological responses. (nature.com)
  • The N-terminus sequence of the present chimeric FGFs identify homology with that of human acidic fibroblast growth factor. (google.com)
  • Fibroblast Growth Factors (FGFs) were first discovered in mammals and the horizon of insect FGF research opened up with the discovery of the first FGF receptor (FGFR) gene in Drosophila melanogaster , suggesting that FGF signalling is evolutionary conserved [ 1 ]. (mdpi.com)
  • Fibroblast growth factors (FGFs) 15/19 and 21 belong to the FGF endocrine subfamily. (wiley.com)
  • Fibroblast Growth Factors (FGFs) comprise a family of at least eighteen structurally realted proteins that are involved in a multitude of physiological and pathological cellular processes, including cell growth, differentation, angiogenesis, wound healing and tumorgenesis. (prospecbio.com)
  • Fibroblast growth factors (FGFs) represent a group of peptides that regulate diverse biological functions, including cell differentiation, cell growth, and angiogenesis ( 1 , 2 ). (diabetesjournals.org)
  • Fibroblast growth factors (FGFs) play a critical role in diverse physiological processes and the pathogenesis of diseases. (mdpi.com)
  • Maintenance of endothelial cells (ECs), the building blocks of the vascular tree, is a presumed function of fibroblast growth factors (FGFs). (eurekaselect.com)
  • Basic and acidic fibroblast growth factors (FGFs) are two closely related peptides of M r =16000 that act as potent mitogens and differentiation factors or a wide variety of mesoderm and neuroectoderm derived cells. (springer.com)
  • Some FGFs are potent angiogenic factors, and most of them play important roles in embryonic development and wound healing ( 4, 5 ). (aacrjournals.org)
  • FGFs secreted by tumors act, on the one hand, in an autocrine manner promoting tumor growth, and, on the other hand, in a paracrine manner on endothelial cells, thereby promoting tumor angiogenesis ( 7 ). (aacrjournals.org)
  • Treatment of basic fibroblast growth factor (bFGF) with organic disulfides, preferably glutathione disulfide, or with inorganic compounds of similar function results in a bFGF composition of enhanced stability and resistance to multimerization. (google.com)
  • These formulations provide a stabilized basic fibroblast growth factor (bFGF) which is less susceptible to oxidation or metal-induced aggregation by including an amount of a chelating agent effective to stabilize the bFGF. (freepatentsonline.com)
  • 1. A stabilized basic fibroblast growth factor pharmaceutical formulation consisting essentially of a basic fibroblast growth factor (bFGF) and a chelating agent or a pharmaceutically acceptable salt thereof in an amount effective to stabilize said bFGF. (freepatentsonline.com)
  • 12. The stabilized bFGF formulation of claim 1 wherein said basic fibroblast growth factor is from a mammalian source. (freepatentsonline.com)
  • 13. The stabilized bFGF formulation of claim 10 which is human basic fibroblast growth factor. (freepatentsonline.com)
  • To investigate the role of mast cells (MC) and their fibrogenic growth factors in silicosis, we performed quantitative immunohistochemistry for MC tryptase and for basic fibroblast growth factor (bFGF) in lung tissue from silicotic and control subjects. (cdc.gov)
  • Basic fibroblast growth factor (bFGF) has been implicated in the brain's trophic response to injury. (uleth.ca)
  • Addition of a single dose of 10 ng/ml basic fibroblast growth factor (bFGF) to the culture medium induced an average increase of sixfold in the numbers of neurons expressing opsin. (jneurosci.org)
  • The MLMCs were used as a graft material in combination with a fusion protein consisting of basic fibroblast growth factor (bFGF), polycystic kidney disease (PKD) domain, and the collagen-binding domain (CBD) of Clostridium histolyticum collagenase. (hindawi.com)
  • In this study, bFGF was also shown to act on preosteoblasts - in the form of an increased proliferation - after binding to fibroblast growth factor receptor 1 and activating phosphoinositide 3-kinase. (primidi.com)
  • Moreover, we have analyzed ES lines carrying targeted mutations for fibroblast growth factor receptor-1 (fgfr1), a receptor for basic fibroblast growth factor (bFGF), as well as scl, a transcription factor, for their potential to generate BL-CFCs and Flk1(+) cells, to further define events leading to hemangioblast development. (biologists.org)
  • The present invention relates to novel chimeric basic fibroblast growth factors and to the enhanced production of such factors (bFGF). (google.com)
  • Although basic fibroblast growth factor (bFGF) is a classical mitogen and survival factor in fibroblasts and endothelial cells, it inhibits proliferation in breast cancer cells. (dtic.mil)
  • Our data confirmed that bFGF increased clonogenic survival of NIH 3T3 fibroblasts alone and prior to treatment with etoposide or 5-fluorouracil, two chemotherapeutic agents with different mechanisms of action, but decreased clonogenic survival of MCF-7 cells and increased their susceptibility to these chemotherapeutic agents in a dose and time dependent manner. (dtic.mil)
  • This messenger RNA encodes a 155-amino acid protein that is 84% identical to the human basic fibroblast growth factor (bFGF). (sciencemag.org)
  • Basic FGF (bFGF pI 9.6) was first identified by its ability to cause the proliferation and phenotypic transformation of BALB-C 3T3 fibroblasts (Gospodarowicz,1974;Gospodarowicz and Moran,1974), while acidic FGF (aFGF, pI 5.6) was first identified by its ability to cause the proliferation and delayed differentiation of myoblasts (Gospodarowicz et al. (springer.com)
  • Basic fibroblast growth factor (bFGF) is a potent angiogenic peptide implicated in the growth and metastasis of solid tumors. (aacrjournals.org)
  • These growth factors typically act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. (wikipedia.org)
  • In humans, 23 members of the FGF family have been identified, all of which are structurally related signaling molecules: Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). (wikipedia.org)
  • These growth factors generally act as systemic or locally circulating molecules of extracellular origin that activate cell surface receptors. (wikipedia.org)
  • Members FGF1 through FGF10 all bind fibroblast growth factor receptors (FGFRs). (wikipedia.org)
  • The fibroblast growth factor receptors (FGFRs) are increasingly considered attractive targets for therapeutic cancer intervention due to their roles in tumor metastasis and angiogenesis. (nature.com)
  • Fibroblast growth factor receptors (FGFRs) can act as driving oncoproteins in certain cancers, making them attractive drug targets. (nature.com)
  • When conjugated to basic fibroblast growth factor (FGF2), it selectively kills proliferating cells that have upregulated FGF receptors. (ahajournals.org)
  • In suspended human fibroblasts, IGF-I tracer binds predominantly to type I IGF receptors (inhibition by IGF-I much greater than insulin greater than B-IGF-I hybrid molecules). (jci.org)
  • Developmental expression of two closely related fibroblast growth factor receptors, bek and flg, is described from early postimplantation until advanced organogenesis. (biologists.org)
  • Gregory J. Chen and Reza Forough, " Fibroblast Growth Factors, Fibroblast Growth Factor Receptors, Diseases, and Drugs", Recent Patents on Cardiovascular Drug Discovery (Discontinued) (2006) 1: 211. (eurekaselect.com)
  • The lung fibroblasts expressed IL-6 receptors on their surface as determined by flow cytometry using a rat anti-mouse IL-6 receptor antibody (15A7). (ovid.com)
  • NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells.The receptors are ligand binding factors of type 1, 2 or 3 and protein-molecules that receive chemical-signals from outside a cell. (gentaur.com)
  • VEGFR vascular endothelial growth factor receptor. (medscape.com)
  • We have previously shown that adipose-derived microvascular endothelial cells (MVECs) secrete a factor(s) that increases proliferation of human preadipocytes. (diabetesjournals.org)
  • 1995 ) Vascularization of the mouse embryo: a study of Flk1, tek, tie, and vascular endothelial growth factor expression during development. (biologists.org)
  • Fibroblast growth factor (FGF) was first described by Gospodarowicz in 1974 (Nature 249: 123-127) as derived from bovine brain or pituitary tissue which was mitogenic for fibroblasts and endothelial cells. (google.com)
  • Basic fibroblast growth factor is one of a class of heparin-binding growth factors that stimulates endothelial cell proliferation and migration in vitro and angiogenesis in vivo. (ovid.com)
  • 7. The use according to claim 5, characterized in that the cells are skin cells, in particular keratinocytes, fibroblasts or endothelial cells. (freepatentsonline.com)
  • In order to evaluate the second efficacy of EGF, the amount of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) produced by fibroblasts were assessed in a wound surface model. (scirp.org)
  • The effect of basic fibroblast growth factor (b-FGF), one of the commonest angiogenic factors in various cancer types, on lymphocyte adhesion and transmigration across the endothelial cell monolayer was investigated using human umbilical vein-derived endothelial cells (HUVEC) and type I collagen gel. (aacrjournals.org)
  • In culture, FGF-4 has been shown to be an important regulator of growth for stem cells, fibroblasts and endothelial cells. (cellsciences.com)
  • Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. (wikipedia.org)
  • Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. (rcsb.org)
  • Here, we show that Fgf4 expression is induced by the transforming growth factor β-related protein Nodal. (pnas.org)
  • Zusätzlich bieten wir Ihnen Fibroblast Growth Factor 16 Proteine (14) und Fibroblast Growth Factor 16 Kits (5) und viele weitere Produktgruppen zu diesem Protein an. (antikoerper-online.de)
  • We are investigating a Fibroblast Growth Factor binding protein that is expressed in embryonal and neuronal tissues, and may be a target of inhibitory antibody therapy for neuroblastoma. (aacrjournals.org)
  • Many of these growth factors are localized to the extracellular milieu and must be transported to their cell surface receptor via a binding protein for activation. (aacrjournals.org)
  • The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. (creative-biogene.com)
  • Not long after FGF1 and FGF2 were isolated, another group of investigators isolated a pair of heparin-binding growth factors that they named HBGF-1 and HBGF-2, while a third group isolated a pair of growth factors that caused proliferation of cells in a bioassay containing blood vessel endothelium cells, which they called ECGF1 and ECGF2. (wikipedia.org)
  • We have previously reported that MVECs derived from human adipose tissue secrete a factor(s) that stimulates proliferation in human subcutaneous and omental (intraabdominal) preadipocytes ( 4 ). (diabetesjournals.org)
  • Their proliferation depends on diffusible signals from neighboring cells in the epiblast, including fibroblast growth factor 4 (Fgf4). (pnas.org)
  • Involved in fibroblast growth factor receptor signaling pathway and positive regulation of cell population proliferation. (mcw.edu)
  • Specifically, engagement of CDH11 promotes fibroblast proliferation, while CDH11 deficiency decrease the proliferation rate significantly. (aiche.org)
  • Polypeptide growth factors are hormone-like modulators of cell proliferation and differentiation. (google.com)
  • 58: 575-606 (1989)) appear to be normal members of a family of heparin-binding growth factors that influence the general proliferation capacity of a majority of mesoderm- and neuroectoderm-derived cells (Gospodarowicz, D., et al. (google.com)
  • The roles of cell proliferation and growth factor-induced signaling pathways were investigated as well as the class II MHC assembly machinery and functional capacity. (wiley.com)
  • In order to assess cellular growth and proliferation, SH-SY5Y cells were transduced with the supernatant of retrovirus-transfected 293T cells, containing FGF-BP3 small interfering RNA, in order to assess the growth of a knockdown FGF-BP3 cell line. (aacrjournals.org)
  • These results indicate that NO released from VSMC induces VSMC death, which results in release of basic fibroblast growth factor, which then stimulates adjacent EC proliferation. (jci.org)
  • This review highlights recent findings that FGF1 directly interacts with integrin αvβ3, and the resulting integrin-FGF-fibroblast growth factor receptor (FGFR) ternary complex formation is essential for FGF1-induced cell proliferation, migration and angiogenesis. (mdpi.com)
  • In order to evaluate the first efficacy of EGF, fibroblast proliferation was assessed after 6 days of cultivation in the conditioned medium prepared by dissolving EGF-skin care product in a conventional culture medium. (scirp.org)
  • Growth factors (GFs) play a key role in regulating important cellular behaviors such as survival, proliferation, migration, and differentiation. (pubmedcentralcanada.ca)
  • Predicted MW: Monomer, 16 kDa (141 aa) Acidic fibroblast growth factor (FGF-acidic), also known as FGF-1, is a potent inducer of DNA synthesis, cell proliferation, and has chemotactic activities. (biomol.com)
  • Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. (gentaur.com)
  • Atherogenesis is characterized by two major mechanisms: (1) excessive proliferation of a variety of cell types in the arterial intima, which is controlled by growth factors and cytokines, and (2) oxidation and accumulation of LDL in the form of both intracellular and extracellular deposits. (ahajournals.org)
  • It successfully suppressed the growth, angiogenesis, and metastasis of two tumor cell lines in vitro and in vivo , and it potently inhibited cancer cell proliferation but not normal cell proliferation. (aacrjournals.org)
  • FGF23 is a member of the fibroblast growth factor (FGF) family which participates in phosphate and vitamin D metabolism and regulation. (wikipedia.org)
  • Disordered phosphate homeostasis with elevated circulating levels of fibroblast growth factor 23 (FGF23) is an early and pervasive complication of CKD. (nih.gov)
  • Fibroblast growth factor 21 (FGF21) is a member of the endocrine subgroup of the FGF family, comprised of FGF19 (FGF15 in mice), FGF21, and FGF23. (frontiersin.org)
  • Fibroblast growth factor-23 (FGF23) is central to phosphate homeostasis. (springer.com)
  • Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement. (springer.com)
  • High levels of fibroblast growth factor 23 (FGF23) have been associated with increased cardiovascular disease and mortality risk in patients with chronic kidney disease (CKD). (renalandurologynews.com)
  • In 1975, they further fractionated the extract using acidic and basic pH and isolated two slightly different forms that were named "acidic fibroblast growth factor" (FGF1) and "basic fibroblast growth factor" (FGF2). (wikipedia.org)
  • These two factors were named acidic and basic FGF, respectively, because they had similar if not identical biological activities but differed in their isolectric points. (google.com)
  • Acidic and basic fibroblast growth factors (recently reviewed by Burgess, W. H., and Maciag, T. Ann. (google.com)
  • Basic fibroblast growth factor stimulates angiogenesis in the hindlimb of hyperglycemic rats," Journal of Surgical Research , vol. 79, no. 1, pp. 8-12, 1998. (hindawi.com)
  • FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. (wikipedia.org)
  • while FGF2, HBGF-2, and ECGF-2 were all the same basic fibroblast growth factor. (wikipedia.org)
  • More specifically, it concerns procedures for stabilizing basic fibroblast growth factor by treatment with disulfides or other compounds capable of forming S--S covalent bonds. (google.com)
  • Mast cell basic fibroblast growth factor in silicosis. (cdc.gov)
  • Basic fibroblast growth factor promotes bone marrow stromal cell transplantation-mediated neural regeneration in traumatic brain injury," Biochemical and Biophysical Research Communications , vol. 359, no. 1, pp. 40-45, 2007. (hindawi.com)
  • Acceleration of peripheral nerve regeneration using nerve conduits in combination with induced pluripotent stem cell technology and a basic fibroblast growth factor drug delivery system," Journal of Biomedical Materials Research A , vol. 102, no. 5, pp. 1370-1378, 2014. (hindawi.com)
  • Stimulation of fracture repair by recombinant human basic fibroblast growth factor in normal and streptozotocin-diabetic rats," Endocrinology , vol. 135, no. 2, pp. 774-781, 1994. (hindawi.com)
  • Stimulation of endosteal bone formation by systemic injections of recombinant basic fibroblast growth factor in rats," Endocrinology , vol. 136, no. 3, pp. 1276-1284, 1995. (hindawi.com)
  • Bone regeneration by basic fibroblast growth factor complexed with biodegradable hydrogels," Biomaterials , vol. 19, no. 7-9, pp. 807-815, 1998. (hindawi.com)
  • Potential efficacy of basic fibroblast growth factor incorporated in biodegradable hydrogels for skull bone regeneration," Journal of Neurosurgery , vol. 86, no. 5, pp. 871-875, 1997. (hindawi.com)
  • Oriented collagen tubes combined with basic fibroblast growth factor promote peripheral nerve regeneration in a 15 mm sciatic nerve defect rat model," Journal of Biomedical Materials Research Part A , vol. 105, no. 1, pp. 8-14, 2017. (hindawi.com)
  • Acceleration effect of basic fibroblast growth factor on the regeneration of peripheral nerve through a 15-mm gap," Journal of Biomedical Materials Research , vol. 66A, no. 3, pp. 522-531, 2003. (hindawi.com)
  • In normal tissue, basic fibroblast growth factor is present in basement membranes and in the subendothelial extracellular matrix of blood vessels. (primidi.com)
  • Fibroblast growth factor receptor 1 ( FGFR1 ), also known as basic fibroblast growth factor receptor 1 , fms-related tyrosine kinase-2 / Pfeiffer syndrome , and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. (primidi.com)
  • Dissociated primary cultures from rat telencephalon at different developmental stages were used to study the effect of basic fibroblast growth factor (FGF2) on Otx2, Dlx1, and Emx1, three homeobox genes expressed in different regions of the developing mammalian forebrain. (jneurosci.org)
  • The present invention relates to novel chimeric fibroblast growth factors (FGF) wherein the alanine at amino acid 3 and serine 5 of native human recombinant basic fibroblast growth factor are replaced with glutamic acid. (google.com)
  • Novel variants of this new glu 3 ,5 basic fibroblast growth factor, such as those in which cysteine 78 and cysteine 96 are replaced, e.g., with serine or other amino acids, to produce stabilized versions of the glu 3 ,5 basic FGF and eliminate disulfide scrambled forms, are also described. (google.com)
  • Although human melanocytes respond to the mitogenic influences of basic fibroblast growth factor but not acidic FGF most avian and mammalian cell types respond to both polypeptides (ibid. (google.com)
  • Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor. (alfa.com)
  • Regeneration of tracheal epithelium using a collagen vitrigel-sponge scaffold containing basic fibroblast growth factor. (biomedsearch.com)
  • In this study, the effectiveness of this scaffold with the application of basic fibroblast growth factor (b-FGF) was investigated. (biomedsearch.com)
  • The purpose of this study was to investigate the expression of basic fibroblast growth factor in chronic periapical lesions of endodontic origin. (ovid.com)
  • Two independent observers graded the staining intensity for basic fibroblast growth factor. (ovid.com)
  • An immunopositive, cytoplasmic, and nuclear reaction for basic fibroblast growth factor, with varying degrees of upregulation was observed in all 10 chronic periapical lesions. (ovid.com)
  • We speculate that the formation of granulation tissue and the activation of epithelial cell rests in chronical apical lesions might be associated with a local rise in the tissue level of basic fibroblast growth factor. (ovid.com)
  • Nitric oxide mediates cytotoxicity and basic fibroblast growth factor release in cultured vascular smooth muscle cells. (jci.org)
  • Furthermore, the concentration of basic fibroblast growth factor in the conditioned medium was increased and correlated with the degree of cytotoxicity in VSMC. (jci.org)
  • FIBROBLAST GROWTH FACTOR, BASIC, HUMAN (CAS 106096-93-9) Market Research Report 2018 aims at providing comprehensive data on fibroblast growth factor, basic, human market globally and regionally (Europe, Asia, North America, Latin America etc. (marketpublishers.com)
  • It captures fibroblast growth factor, basic, human market trends, pays close attention to fibroblast growth factor, basic, human manufacturers and names suppliers. (marketpublishers.com)
  • In addition to the above the report determines fibroblast growth factor, basic, human consumers. (marketpublishers.com)
  • FIBROBLAST GROWTH FACTOR, BASIC, HUMAN (CAS 106096-93-9) Market Research Report 2018 contents were prepared and placed on the website in February, 2018. (marketpublishers.com)
  • Please note that FIBROBLAST GROWTH FACTOR, BASIC, HUMAN (CAS 106096-93-9) Market Research Report 2018 is a half ready publication and contents are subject to change. (marketpublishers.com)
  • The Role of Basic Fibroblast Growth Factor in Human Breast Cancer. (dtic.mil)
  • Basic fibroblast growth factor (FGF-2) is a trophic molecule involved in a number of functions within the central nervous system (CNS), including a prominent role in the regulation of CNS responses to injury. (uleth.ca)
  • We examined the structure and function of CD4 T cell-derived LMCs, and we established a role for ASMC-derived basic fibroblast growth factor 2 (FGF2b) and FGF receptor (FGFR)1 in LMC formation. (jimmunol.org)
  • Diagnostic and prognostic role of basic fibroblast growth factor in Wilms' tumor patients. (aacrjournals.org)
  • FGFR2 is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, and mutations in FGFR2 are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. (creativebiomart.net)
  • To document the specificity and the mechanism of induction of a novel class II major histocompatibility complex (MHC) antigen by mitogenic growth factors in human mesenchymal stem cells (MSCs) expanded in vitro for translational applications. (wiley.com)
  • This EGF and VC-incorporating wound dressing showed a higher potential to facilitate production of VEGF and HGF by fibroblast in vitro, and enhance granulation tissue formation associated with angiogenesis and collagen deposition in vivo, compared with the EGF-incorporating wound dressing. (scirp.org)
  • Gospodarowicz, D., 1979, Fibroblast and epidermal growth factors: their uses in vivo and in vitro in studies on cell functions and cell transplantation, Mol. (springer.com)
  • The Fibroblast Growth Factor Receptor FGFR2-IIIb splicing isoform (FGFR2b) and its high affinity ligand Fibroblast Growth Factor 10 (FGF10) are expressed in the epithelium and mesenchyme, respectively, and therefore are well positioned to transmit mesenchymal to epithelial signaling. (frontiersin.org)
  • Fgf7 and Fgf10, the main ligands for FgfR2-IIIb, are expressed in the mesenchyme surrounding the thymic epithelial primordium, and Fgf10 -deficient mice also exhibit impaired thymic growth. (jimmunol.org)
  • Additionally, interactions between FGFR signaling and other receptor tyrosine kinase networks, such as those mediated by the epidermal growth factor receptor and platelet-derived growth factor receptor α, were associated with excessive osteoblast differentiation and bone formation in the human skeletal dysplasia called craniosynostosis, which is a disorder of skull development. (sciencemag.org)
  • The prototypical fibroblast growth factor receptor (FGFR) extracellular domain consists of three Ig domains (D1-D3) of which the two membrane-proximal D2 and D3 domains and the interconnecting D2-D3 linker bear the determinants of ligand binding and specificity. (pnas.org)
  • The fibroblast growth factor receptor (FGFR) family comprises 4 members: FGFR1-4 [ 1 ]. (nature.com)
  • absence of deregulated FGFR or the presence of other oncogenic drivers (human epidermal growth factor receptor 2 (HER2) or RAS) is associated with intrinsic resistance. (nature.com)
  • Achondroplasia, the most common form of chondrodysplasia, has been associated with mutations in the gene of the fibroblast growth factor receptor-3 (FGFR-3) on chromosome 4p. (sigmaaldrich.com)
  • Crosstalk of fibroblast growth factor signaling with other pathways may offer therapeutic strategies for skeletal dysplasias. (sciencemag.org)
  • 1-3 ⇓ ⇓ Fibroblast growth factor-1 (FGF-1) is a member of a large family of heparin-binding growth factors. (ahajournals.org)
  • A mitogenic growth factor activity was found in pituitary extracts by Armelin in 1973 and further work by Gospodarowicz as reported in 1974 described a more defined isolation of proteins from cow brain extract which, when tested in a bioassay that caused fibroblasts to proliferate, led these investigators to apply the name "fibroblast growth factor. (wikipedia.org)
  • These independently discovered proteins were eventually demonstrated to be the same sets of molecules, namely FGF1, HBGF-1 and ECGF-1 were all the same acidic fibroblast growth factor described by Gospodarowicz, et al. (wikipedia.org)
  • The fibroblast growth factors (FGF) are a family of cell signalling proteins that are involved in a wide variety of processes, most notably as crucial elements for normal development. (wikipedia.org)
  • Growth factors and their binding proteins play an important role in the potentiation and angiogenesis of solid tumors. (aacrjournals.org)
  • The Heparin-Binding (Fibroblast) Growth Factor Family of Proteins. (alfa.com)
  • Modulation of insulinlike growth factor I binding to human fibroblast monolayer cultures by insulinlike growth factor carrier proteins released to the incubation media. (jci.org)
  • In support of this hypothesis, carrier proteins were demonstrated in the media at the end of the binding incubation with fibroblast monolayers, and the concentration of unsaturated binding sites in the media correlated inversely with tracer binding to the cells. (jci.org)
  • Description Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. (gentaur.com)
  • Regeneration of the subepithelial layer, infiltration of inflammatory cells and fibroblasts, and angiogenesis were promoted earlier in the scaffolds with b-FGF application. (biomedsearch.com)
  • FGF signaling seems to play a role in tumor growth and angiogenesis, and autocrine FGF signaling may be particularly important in the progression of steroid hormone-dependent cancers to a hormone-independent state ( 6 ). (aacrjournals.org)
  • Fibroblast Growth Factor (FGF) signalling induces changes in cellular behaviour allowing cells in the embryo to move, to survive, to divide or to differentiate. (mdpi.com)
  • Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. (semanticscholar.org)
  • 1,3 ⇓ OxLDL induces a number of cytokines and growth factors in vascular cells, exerts mitogenic effects at low concentrations and cytotoxic effects at high concentrations, and are also implicated in the progression of the plaque to vulnerable, highly thrombogenic atheroma. (ahajournals.org)
  • Fibroblast growth factor induces a neural stem cell phenotype in foetal forebrain progenitors and during embryonic stem cell differentiation. (biomedsearch.com)
  • Database searches and analysis of available genomic DNA sequence from the region revealed the presence of the fibroblast growth factor homologous factor gene, FHF2 , within the duplication breakpoint interval. (springer.com)
  • Two other growth factors known to exert neurotrophic effects, epidermal and nerve growth factor, were without effect. (jneurosci.org)
  • Numerous shorthand names have been applied to active factors in these extracts, including epidermal growth factor, platelet-derived growth factor, nerve growth factor, hematopoietic growth factor and fibroblast growth factor. (google.com)
  • This study aimed to investigate the potential of a skin care product composed of hyaluronic acid (HA) and collagen (Col) sponge containing epidermal growth factor (EGF), vitamin C derivative (VC), glucosylceramide (GC), poly(γ-glutamic acid) (PGA), and argentine (Arg). (scirp.org)
  • Expression of class II MHC molecules was measured in human MSCs and differentiated cells expanded in the presence of fibroblast growth factor 2 (FGF-2), platelet-derived growth factor BB (PDGF-BB), human platelet lysate, or interferon-γ (IFNγ). (wiley.com)
  • We therefore suggest that FGF-1 is a key human adipogenic factor, and these data expand our understanding of human fat tissue growth and have significant potential for development of novel therapeutic strategies in the prevention and management of human obesity. (diabetesjournals.org)
  • To develop more sustainable therapies for the treatment of obesity, a better understanding of human adipose tissue growth is essential. (diabetesjournals.org)
  • Therefore, paracrine interaction between MVECs in the developing capillary network and preadipocytes resident in the adipose tissue depots may play a role in the regulation of adipose tissue growth. (diabetesjournals.org)
  • Here we show that a well-known growth factor, FGF2, long thought to be involved in many developmental and homeostatic processes, including growth of the tissue layers of vessel walls, functions in vascular tone control. (nih.gov)
  • Fibroblast growth factor receptor 2 (FGFR2) is thought to mediate an important signaling pathway between prostate epithelial cells and stromal cells for maintenance of homeostasis in normal prostate tissue. (sigmaaldrich.com)
  • Fibroblast growth factor-21 is expressed in neonatal and pheochromocytoma-induced adult human brown adipose tissue. (semanticscholar.org)
  • Serum concentrations and tissue expression of a novel endocrine regulator fibroblast growth factor-21 in patients with type 2 diabetes and obesity. (semanticscholar.org)
  • A gene on chromosome 15q21.2 that encodes fibroblast growth factor 7 of the FGF family, which bind heparin and have a broad range of cellular activities, including cell survival, division, differentiation and migration, embryonic development, morphogenesis, tissue repair, tumour growth and invasion. (thefreedictionary.com)
  • However, the use of growth factors as therapeutic agents can be costly and does not always bring about efficient tissue repair due to rapid clearance from the targeted site. (pubmedcentralcanada.ca)
  • A new regenerative scaffold made of biosafe collagen hydrogel and collagensponge could possess the ability of retaining fibroblastic growth factor-2 (FGF2) and stimulate the periodontal tissue regeneration, according to new research published in The Open Dentistry Journal . (brightsurf.com)
  • However, it is difficult to reform periodontal attachment because the rapid growth of the junctional epithelium and gingival connective tissue inhibit the growth of periodontal tissue associated with periodontal attachment. (brightsurf.com)
  • FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. (creative-biogene.com)
  • The induction of functional HLA-DR in proliferating progenitor MSCs is a property of human MSCs that have been expanded with mitogenic growth factors. (wiley.com)
  • 1994 ) Murine FGFR1 is required for early postimplantation growth and axial organization. (biologists.org)
  • Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets. (ovid.com)
  • however, it was not known whether all murine lung fibroblasts secreted IL-6 or only subsets thereof. (ovid.com)
  • Previous studies in our laboratory have shown that murine lung fibroblasts can be divided into subpopulations based on Thy 1 expression. (ovid.com)
  • IL-6 mRNA was detected in both Thy 1+ and Thy 1- murine fibroblasts and clones using reverse transcriptase polymerase chain reaction (RT-PCR). (ovid.com)
  • Also, IL-6 activity was detected in the supernatants of murine lung fibroblast lines and clones using an IL-6-dependent hybridoma assay. (ovid.com)
  • Gospodarowicz, D., 1974, Localization of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth, Nature , London 249: 123-127. (springer.com)
  • It is produced by many cell types, including lymphocytes, macrophages, and fibroblasts, and is believed to play a major role in pulmonary fibrosis, a condition resulting from expansion of the fibroblast compartment and the accumulation of extracellular matrices secreted primarily by fibroblasts. (ovid.com)
  • In contrast, FGF7 (keratinocyte growth factor, KGF) binds only to FGFR2b (KGFR). (wikipedia.org)
  • 9 Another alternative is to chemically attach heparin, a glycosaminoglycan capable of binding multiple GFs, into the polymer scaffold, as a way to deliver growth factors without relying on recombinant GF variants. (pubmedcentralcanada.ca)
  • Here we report our recent discovery, that in cooperation with platelet derived growth factor receptor (PDGFRβ), CDH11 regulate cell growth via the PDGFRβ-AKT axis. (aiche.org)
  • Interestingly, CDH11 engagement upregulated the expression of platelet derived growth factor receptor beta (PDGFRβ), as evidenced by shCDH11 knockdown in human fibroblasts and cdh11 -/- mouse cells. (aiche.org)
  • Restoration of fibroblast growth factor receptor 2IIIb enhances the chemosensitivity of human prostate cancer cells. (sigmaaldrich.com)
  • Fibroblast growth factor 21 (209 aa, ~22 kDa) is encoded by the human FGF21 gene. (semanticscholar.org)
  • Here, we show that BL-CFC expresses the receptor tyrosine kinase, Flk1, and thus we took advantage of the BL-CFC assay, as well as fluorescent activated cell sorter (FACS) analysis for Flk1(+) cells to determine quantitatively if mesoderm-inducing factors promote hematopoietic lineage development. (biologists.org)
  • They express essential transcription factors such as the estrogen-related receptor β (Errβ), Eomesodermin, and Cdx2, together with Bmp4, but repress differentiation markers such as Mash2. (pnas.org)
  • Intercellular signalling via growth factors plays an important role in controlling cell differentiation and cell movements during the development of multicellular animals. (mdpi.com)
  • FGFR2 is a member of the fibroblast growth factor receptor family which play a role in mitogenesis and differentiation. (creativebiomart.net)
  • Fibroblast growth factor 21 (FGF21) is a pleotropic metabolic regulator, expression of which is elevated during fasting. (frontiersin.org)
  • OBJECTIVE Fibroblast growth factor-21 (FGF21) is a novel endocrine and paracrine regulator of metabolic homeostasis. (semanticscholar.org)
  • 15 These results suggest that disordered phosphorus metabolism is a novel risk factor for cardiovascular disease. (ahajournals.org)
  • OBJECTIVE Fibroblast growth factor (FGF)-21 is highly expressed in the liver and regulates hepatic glucose production and lipid metabolism in rodents. (diabetesjournals.org)
  • Takkavatakarn K, Wuttiputhanun T, Phannajit J, Praditpornsilpa K, Eiam‑Ong S, Susantitaphong P. Effectiveness of fibroblast growth factor 23 lowering modalities in chronic kidney disease: a systematic review and meta‑analysis . (renalandurologynews.com)
  • Growth factors are responsible for the regulation of a variety of physiological processes, including development, regeneration and wound repair. (google.com)
  • A fibroblast growth factor that may play a role in regulation of HAIR FOLLICLE phenotype. (umassmed.edu)
  • Binding of fibroblast growth factors produces receptor dimerization, autophosphorilation and signal transduction. (atlasgeneticsoncology.org)
  • Like the natriuretic peptides, fibroblast growth factor 23 (FGF-23) could become important in risk-stratifying and managing HF patients. (aacc.org)
  • The Fibroblast Growth Factor (FGF) family of peptides and the corresponding family of receptor tyrosine kinases (RTKs) collectively constitute one of the most adaptable, complex, and diverse growth factor signaling systems that are involved in many developmental and repair processes in virtually all vertebrate and invertebrate tissues and cells ( Goetz and Mohammadi, 2013 ). (frontiersin.org)
  • To investigate the frequency and the prognostic impact of fibroblast growth factor receptor 1 (FGFR1) gene amplification in 526 curatively resected esophageal squamous cell carcinoma (ESCC). (unboundmedicine.com)
  • The fibroblast growth factor (FGF) signaling pathway is a recognized target of cancer therapy. (aacrjournals.org)
  • A new paper in Development investigates the roles of Fgf signalling and Tbx transcription factors in zebrafish muscle development. (biologists.org)
  • Interestingly, semi-quantitative RT-PCR and Northern blot analysis demonstrated that IL-6 mRNA was down-regulated in confluent fibroblast cultures versus cultures in log phase growth. (ovid.com)
  • Background- Fibroblast growth factor 23 (FGF-23) is a phosphorus-regulating hormone. (ahajournals.org)
  • Fibroblast growth factor 23 (FGF-23) is a recently discovered hormone that helps maintain normal serum phosphate concentrations in patients with kidney disease by stimulating urinary phosphate excretion and decreasing dietary phosphorus absorption through the inhibition of 1,25-dihydroxyvitamin D [1,25(OH) 2 D] synthesis. (ahajournals.org)
  • 2) examine the effect of phosphorus restriction/fibroblast growth factor-23 (FGF-23)reduction strategies on insulin resistance and cardiac structure and function in individuals with renal dysfunction. (clinicaltrials.gov)