Carboxypeptidase U
A metallocarboxypeptidase that removes C-terminal lysine and arginine from biologically active peptides and proteins thereby regulating their activity. It is a zinc enzyme with no preference shown for lysine over arginine. Pro-carboxypeptidase U in human plasma is activated by thrombin or plasmin during clotting to form the unstable carboxypeptidase U.
Fibrin
Blood Coagulation
Tissue Plasminogen Activator
A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
alpha-2-Antiplasmin
A member of the serpin superfamily found in plasma that inhibits the lysis of fibrin clots which are induced by plasminogen activator. It is a glycoprotein, molecular weight approximately 70,000 that migrates in the alpha 2 region in immunoelectrophoresis. It is the principal plasmin inactivator in blood, rapidly forming a very stable complex with plasmin.
Plasminogen Activator Inhibitor 1
Plasminogen
Fibrinolysin
A product of the lysis of plasminogen (profibrinolysin) by PLASMINOGEN activators. It is composed of two polypeptide chains, light (B) and heavy (A), with a molecular weight of 75,000. It is the major proteolytic enzyme involved in blood clot retraction or the lysis of fibrin and quickly inactivated by antiplasmins.
Antifibrinolytic Agents
Fibrin Fibrinogen Degradation Products
Thrombomodulin
Fibrinogen
Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.
Hemostasis
Plasminogen Activators
Carboxypeptidase B
Urokinase-Type Plasminogen Activator
Serum Globulins
Thrombolytic Therapy
Antithrombin III
Plasminogen Inactivators
Factor XIII
Thrombelastography
Protein C
Blood Coagulation Disorders
Carboxypeptidases
Blood Coagulation Factors
Disseminated Intravascular Coagulation
Streptokinase
Gravity Suits
Double-layered inflatable suits which, when inflated, exert pressure on the lower part of the wearer's body. The suits are used to improve or stabilize the circulatory state, i.e., to prevent hypotension, control hemorrhage, and regulate blood pressure. The suits are also used by pilots under positive acceleration.
Aminocaproic Acid
Aminocaproates
Prothrombin Time
Prothrombin
Heparin
A highly acidic mucopolysaccharide formed of equal parts of sulfated D-glucosamine and D-glucuronic acid with sulfaminic bridges. The molecular weight ranges from six to twenty thousand. Heparin occurs in and is obtained from liver, lung, mast cells, etc., of vertebrates. Its function is unknown, but it is used to prevent blood clotting in vivo and vitro, in the form of many different salts.
Enoxaparin
Factor XII
Stable blood coagulation factor activated by contact with the subendothelial surface of an injured vessel. Along with prekallikrein, it serves as the contact factor that initiates the intrinsic pathway of blood coagulation. Kallikrein activates factor XII to XIIa. Deficiency of factor XII, also called the Hageman trait, leads to increased incidence of thromboembolic disease. Mutations in the gene for factor XII that appear to increase factor XII amidolytic activity are associated with HEREDITARY ANGIOEDEMA TYPE III.
Thromboplastin
Partial Thromboplastin Time
The time required for the appearance of FIBRIN strands following the mixing of PLASMA with phospholipid platelet substitute (e.g., crude cephalins, soybean phosphatides). It is a test of the intrinsic pathway (factors VIII, IX, XI, and XII) and the common pathway (fibrinogen, prothrombin, factors V and X) of BLOOD COAGULATION. It is used as a screening test and to monitor HEPARIN therapy.
Myocardial Infarction
Annexin A2
A member of the annexin family that is a substrate for a tyrosine kinase, ONCOGENE PROTEIN PP60(V-SRC). Annexin A2 occurs as a 36-KDa monomer and in a 90-KDa complex containing two subunits of annexin A2 and two subunits of S100 FAMILY PROTEIN P11. The monomeric form of annexin A2 was formerly referred to as calpactin I heavy chain.
Antithrombins
Blood Platelets
Serpin E2
Hemorrhagic Disorders
Peptide Hydrolases
Thrombin Time
Clotting time of PLASMA mixed with a THROMBIN solution. It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. BATROXOBIN, a thrombin-like enzyme unaffected by the presence of heparin, may be used in place of thrombin.
Factor VII
Intracranial Thrombosis
Clot Retraction
Factor XI
Myocardial Reperfusion
Generally, restoration of blood supply to heart tissue which is ischemic due to decrease in normal blood supply. The decrease may result from any source including atherosclerotic obstruction, narrowing of the artery, or surgical clamping. Reperfusion can be induced to treat ischemia. Methods include chemical dissolution of an occluding thrombus, administration of vasodilator drugs, angioplasty, catheterization, and artery bypass graft surgery. However, it is thought that reperfusion can itself further damage the ischemic tissue, causing MYOCARDIAL REPERFUSION INJURY.
Treatment Outcome
Hereditary Angioedema Types I and II
Forms of hereditary angioedema that occur due to mutations in the gene for COMPLEMENT C1 INHIBITOR PROTEIN. Type I hereditary angioedema is associated with reduced serum levels of complement C1 inhibitor protein. Type II hereditary angioedema is associated with the production of a non-functional complement C1 inhibitor protein.
Lipoprotein(a)
A lipoprotein that resembles the LOW-DENSITY LIPOPROTEINS but with an extra protein moiety, APOPROTEIN (A) also known as APOLIPOPROTEIN (A), linked to APOLIPOPROTEIN B-100 on the LDL by one or two disulfide bonds. High plasma level of lipoprotein (a) is associated with increased risk of atherosclerotic cardiovascular disease.
Biological Markers
Measurable and quantifiable biological parameters (e.g., specific enzyme concentration, specific hormone concentration, specific gene phenotype distribution in a population, presence of biological substances) which serve as indices for health- and physiology-related assessments, such as disease risk, psychiatric disorders, environmental exposure and its effects, disease diagnosis, metabolic processes, substance abuse, pregnancy, cell line development, epidemiologic studies, etc.
Aprotinin
A single-chain polypeptide derived from bovine tissues consisting of 58 amino-acid residues. It is an inhibitor of proteolytic enzymes including CHYMOTRYPSIN; KALLIKREIN; PLASMIN; and TRYPSIN. It is used in the treatment of HEMORRHAGE associated with raised plasma concentrations of plasmin. It is also used to reduce blood loss and transfusion requirements in patients at high risk of major blood loss during and following open heart surgery with EXTRACORPOREAL CIRCULATION. (Reynolds JEF(Ed): Martindale: The Extra Pharmacopoeia (electronic version). Micromedex, Inc, Englewood, CO, 1995)
von Willebrand Factor
A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor.
Paracentesis
Platelet Activation
Coagulation and fibrinolysis in intact hydatidiform molar pregnancy. (1/1717)
Tests of coagulation, fibrinolysis, and platelet function were performed in 17 patients with intact molar pregnancies. Women with intact molar pregnancies had higher fibrinogen factor VIII, and fibrinogen degradation products, concentrations and lower prothrombin, factor X, plasminogen, and plasminogen activator concentrations than controls with normal pregnancies. They also had reduced platelet counts and thromboelastographic values, which indicated hypocoagulability. These results suggest that intravascular coagulation occurs in intact hydatidiform molar pregnancies. (+info)Isolation of SMTP-3, 4, 5 and -6, novel analogs of staplabin, and their effects on plasminogen activation and fibrinolysis. (2/1717)
Four novel triprenyl phenol metabolites, designated SMTP-3, -4, -5, and -6, have been isolated from cultures of Stachybotrys microspora IFO 30018 by solvent extraction and successive chromatographic fractionation using silica gel and silica ODS columns. A combination of spectroscopic analyses showed that SMTP-3, -4, -5, and -6 are staplabin analogs, containing a serine, a phenylalanine, a leucine or a tryptophan moiety in respective molecules in place of the N-carboxybutyl portion of the staplabin molecule. SMTP-4, -5, and -6 were active at 0.15 to 0.3 mM in enhancing urokinase-catalyzed plasminogen activation and plasminogen binding to fibrin, as well as plasminogen- and urokinase-mediated fibrinolysis. On the other hand, the concentration of staplabin required to exert such effects was 0.4 to 0.6 mM, and SMTP-3 was inactive at concentrations up to 0.45 mM. (+info)Regulation of the activities of thrombin and plasmin by cholesterol sulfate as a physiological inhibitor in human plasma. (3/1717)
Thrombin and plasmin, both of which are serine proteases in the plasma of vertebrates, play essential roles in blood clotting and fibrinolysis, respectively, and regulation of their activities is important to suppress the excessive reactions within the vascular network and to prevent tissue injury. Along with the peptidic inhibitors belonging to the serpin family, we found that cholesterol sulfate (CS), which is present at the concentration of 2.0+/-1.2 nmol/ml in human plasma, was a potent inhibitor of both plasma thrombin and plasmin. Thrombin, as determined both using a chromogenic substrate and the natural substrate, fibrinogen, was inactivated upon reaction with CS in a dose-dependent manner, but not in the presence of the structurally related steroid sulfates, I3SO3-GalCer and II3NAalpha-LacCer, suggesting that both the sulfate group and the hydrophobic side chain of CS are necessary for the inhibitory activity of CS. Preincubation of thrombin with CS at 37 degrees C for 10 min was required to achieve maximum inhibition, and virtually complete inhibition was achieved at a molar ratio of CS to thrombin of 18:1. CS-treated thrombin had the same Km and a lower Vmax than the original enzyme, and a higher molecular weight. The molecular weight and activity of the original enzyme were not observed on the attempted separation of the CS-treated enzyme by gel permeation chromatography and native PAGE, indicating that the inactivation of thrombin by CS is irreversible. In contrast, CS was readily liberated from the enzyme by SDS-PAGE, suggesting that hydrophobic interactions are involved in the CS-mediated inactivation of thrombin. When acidic lipids were reacted with thrombin after dissolving them in DMSO, I3SO3-GalCer, steroid sulfates and II3NAalpha-LacCer, as well as CS, but not SDS and sodium taurocholate, exhibited inhibitory activity, probably due to micellar formation facilitating interaction between thrombin and negatively charged lipids. On the other hand, plasmin, as determined using a chromogenic substrate, was more susceptible to acidic lipids than thrombin. CS, I3SO3-GalCer and II3NAalpha-LacCer, all of which are present in serum, inhibited the activity of plasmin in aqueous media, as well as in DMSO-mediated lipid solutions. Thus, acidic lipids in plasma were demonstrated to possess regulatory activity as endogenous detergents toward both enzymes for blood clotting and fibrinolysis. (+info)Distinct contributions of residue 192 to the specificity of coagulation and fibrinolytic serine proteases. (4/1717)
Archetypal members of the chymotrypsin family of serine proteases, such as trypsin, chymotrypsin, and elastase, exhibit relatively broad substrate specificity. However, the successful development of efficient proteolytic cascades, such as the blood coagulation and fibrinolytic systems, required the evolution of proteases that displayed restricted specificity. Tissue-type plasminogen activator (t-PA), for example, possesses exquisitely stringent substrate specificity, and the molecular basis of this important biochemical property of t-PA remains obscure. Previous investigations of related serine proteases, which participate in the blood coagulation cascade, have focused attention on the residue that occupies position 192 (chymotrypsin numbering system), which plays a pivotal role in determining both the inhibitor and substrate specificity of these enzymes. Consequently, we created and characterized the kinetic properties of new variants of t-PA that contained point mutations at position 192. These studies demonstrated that, unlike in coagulation serine proteases, Gln-192 does not contribute significantly to the substrate or inhibitor specificity of t-PA in physiologically relevant reactions. Replacement of Gln-192 with a glutamic acid residue did, however, decrease the catalytic efficiency of mature, two-chain t-PA toward plasminogen in the absence of a fibrin co-factor. (+info)Age-related changes in blood coagulation and fibrinolysis in mice fed on a high-cholesterol diet. (5/1717)
To investigate the pathogenesis of hyperlipidemia-induced atherosclerosis, we examined age-dependent changes in platelet activity, blood coagulation and fibrinolysis in susceptibility to a high cholesterol diet (HCD) feeding in male ICR mice. Pretreatment of platelet-rich-plasma from HCD feeding mice for 3 days with epinephrine (300 microM) resulted in a marked enhancement of adenosine 5'-diphosphate (ADP: 0.1 microM) or collagen (0.7 microgram/ml)-stimulated aggregation compared with the same in control mice. Yohimbine as alpha 2-adrenergic blocker antagonized these aggregations in a dose-dependent manner. A significant increase in plasma total cholesterol and VLDL (very low-density lipoprotein)-LDL (low-density lipoprotein)-cholesterol and the liver/body weight ratio was observed in mice fed on HCD for 3 months (3-month HCD mice). In the early phase of this experiment, a significant increase in fibrinogen was observed. In the middle phase, increases in the activity of antithrombin III (ATIII) and alpha 2-plasmin inhibitor (alpha 2-Pl) followed. Plasminogen content gradually decreased in both normal diet and HCD mice throughout the experiment. The activity of plasminogen activator inhibitor (PAI) decreased in 3-month HCD mice. Morphological observation of the aortic arch from 3-month HCD mice revealed apparent atheromatous plaques not seen in control mice. These results suggest that 3-month HCD mice can be a convenient hyperlipidemia-induced atherosclerotic model and the changes in platelet activity, coagulation and fibrinolysis in the early phase may be a cause of pathologic changes in this model. (+info)Fibrinolytic activation markers predict myocardial infarction in the elderly. The Cardiovascular Health Study. (6/1717)
Coagulation factor levels predict arterial thrombosis in epidemiological studies, but studies of older persons are needed. We studied 3 plasma antigenic markers of fibrinolysis, viz, plasminogen activator inhibitor-1 (PAI-1), fibrin fragment D-dimer, and plasmin-antiplasmin complex (PAP) for the prediction of arterial thrombosis in healthy elderly persons over age 65. The study was a nested case-control study in the Cardiovascular Health Study cohort of 5201 men and women >/=65 years of age who were enrolled from 1989 to 1990. Cases were 146 participants without baseline clinical vascular disease who developed myocardial infarction, angina, or coronary death during a follow-up of 2.4 years. Controls remained free of cardiovascular events and were matched 1:1 to cases with respect to sex, duration of follow-up, and baseline subclinical vascular disease status. With increasing quartile of D-dimer and PAP levels but not of PAI-1, there was an independent increased risk of myocardial infarction or coronary death, but not of angina. The relative risk for D-dimer above versus below the median value (>/=120 microg/L) was 2.5 (95% confidence interval, 1.1 to 5.9) and for PAP above the median (>/=5.25 nmol/L), 3.1 (1.3 to 7.7). Risks were independent of C-reactive protein and fibrinogen concentrations. There were no differences in risk by sex or presence of baseline subclinical disease. D-dimer and PAP, but not PAI-1, predicted future myocardial infarction in men and women over age 65. Relationships were independent of other risk factors, including inflammation markers. Results indicate a major role for these markers in identifying a high risk of arterial disease in this age group. (+info)Relationship of plasmin generation to cardiovascular disease risk factors in elderly men and women. (7/1717)
Plasmin-alpha2-antiplasmin complex (PAP) marks plasmin generation and fibrinolytic balance. We recently observed that elevated levels of PAP predict acute myocardial infarction in the elderly, yet little is known about the correlates of PAP. We measured PAP in 800 elderly subjects who were free of clinical cardiovascular disease in 2 cohort studies: the Cardiovascular Health Study and the Honolulu Heart Program. Median PAP levels did not differ between the Cardiovascular Health Study (6.05+/-1.46 nmol/L) and the Honolulu Heart Program (6.11+/-1.44 nmol/L), and correlates of PAP were similar in both cohorts. In CHS, PAP levels increased with age (r=0. 30), procoagulant factors (eg, factor VIIc, r=0.15), thrombin activity (prothrombin fragment F1+2, r=0.29), and inflammation-sensitive proteins (eg, fibrinogen, r=0.44; factor VIIIc, r=0.37). PAP was associated with increased atherosclerosis as measured by the ankle-arm index (AAI) (P for trend, +info)Relative contribution of insulin and its precursors to fibrinogen and PAI-1 in a large population with different states of glucose tolerance. The Insulin Resistance Atherosclerosis Study (IRAS). (8/1717)
Hyperinsulinemia is associated with the development of coronary heart disease. However, the underlying mechanisms are still poorly understood. Hypercoagulability and impaired fibrinolysis are possible candidates linking hyperinsulinism with atherosclerotic disease, and it has been suggested that proinsulin rather than insulin is the crucial pathophysiological agent. The aim of this study was to investigate the relationship of insulin and its precursors to markers of coagulation and fibrinolysis in a large triethnic population. A strong and independent relationship between plasminogen activator inhibitor-1 (PAI-1) antigen and insulin and its precursors (proinsulin, 32-33 split proinsulin) was found consistently across varying states of glucose tolerance (PAI-1 versus fasting insulin [proinsulin], r=0.38 [r=0.34] in normal glucose tolerance; r=0.42 [r=0.43] in impaired glucose tolerance; and r=0.38 [r=0.26] in type 2 diabetes; all P<0.001). The relationship remained highly significant even after accounting for insulin sensitivity as measured by a frequently sampled intravenous glucose tolerance test. In a stepwise multiple regression model after adjusting for age, sex, ethnicity, and clinic, both insulin and its precursors were significantly associated with PAI-1 levels. The relationship between fibrinogen and insulin and its precursors was significant in the overall population (r=0.20 for insulin and proinsulin; each P<0.001) but showed a more inconsistent pattern in subgroup analysis and after adjustments for demographic and metabolic variables. Stepwise multiple regression analysis showed that proinsulin (split products) but not fasting insulin significantly contributed to fibrinogen levels after adjustment for age, sex, clinic, and ethnicity. Decreased insulin sensitivity was independently associated with higher PAI-1 and fibrinogen levels. In summary, we were able to demonstrate an independent relationship of 2 crucial factors of hemostasis, fibrinogen and PAI-1, to insulin and its precursors. These findings may have important clinical implications in the risk assessment and prevention of macrovascular disease, not only in patients with overt diabetes but also in nondiabetic subjects who are hyperinsulinemic. (+info)
Fibrinolysis és érbetegségek.<...
Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers. - Oxford...
Fibrinolysis - Wikipedia
Coagulation and fibrinolysis in injured patients | Journal of Clinical Pathology
Hypercholesterolaemia and lipid lowering treatment do not affect the acute endogenous fibrinolytic capacity in vivo<...
Defective Fibrinolysis in Non-Insulin-Dependent Diabetics Relates to Plasma Insulin Concentrations | Clinical Science |...
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Does apolipoprotein(a) heterogeneity influence lipoprotein(a) effects on fibrinolysis? | Blood | American Society of Hematology
The effect of exercise and heart rate on fibrinolytic activity. - Radcliffe Department of Medicine
Download Proteolytic Enzymes In Coagulation, Fibrinolysis, And Complement Activation Part A: Mammalian Blood Coagulation...
Impaired fibrinolysis-inducing capacity for postinjury phenotype of cultivated human arterial and human atherosclerotic intimal...
Reduced fibrinolytic activity in glomeruli isolated from rabbits infused with tumor necrosis factor<...
Effect of exercise training on fibrinolytic function in individuals with peripheral arterial disease (abstract). - USQ ePrints
Plasmin catalyzed fibrinolysis as quantified by a new kinetic method<...
Prevalence of Clinical and Laboratory Markers of Hypofibrinolysis in Psychotic Patients - Full Text View - ClinicalTrials.gov
A Method for Studying Changes in Profibrinolysin Titer in Dogs Following in Vivo Induction of Fibrinolytic Activity
October | 2020 | bcl-2 inhibitors
Model thrombi formed under flow reveal the role of factor XIII-mediated cross-linking in resistance to fibrinolysis - MUTCH -...
Increased fibrin turnover and high PAI-1 activity as predictors of ischemic events in atherosclerotic patients. A case-control...
Blood Coagulation and Fibrinolysis - Publikationer
- Forskning - Rigshospitalet
Effect of Fibrinolysis Inhibition on the Growth and Hematogenous Dissemination of Cancer | Springer for Research & Development
Angiotensin-Converting Enzyme Inhibition Alters the Fibrinolytic Response to Cardiopulmonary Bypass | Circulation
P-31 A child with a positive lupus anticoagulant who underwe... : Blood Coagulation & Fibrinolysis
Blood Coagulation & Fibrinolysis
Fibrinogen, thrombosis, coagulation, and fibrinolysis - College of Physicians of Philadelphia
Association of pulse pressure with fibrinolysis in patients with type 2 diabetes.
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Heiko Herwald - Lund University
Long-term survival with HIV-infection : the reverse side of the medal
Enhancement of the Fibrinolytic Activity in Plasma by Oral Administration of Nattokinases - Abstract - Acta Haematologica 1990,...
Clotting Deficiency (Liver Related) in Dogs | PetMD
Reason why MS gets better during pregancy?
Inhibition of Coagulation and Fibrinolysis - AMA Manual of Style
Inhibition of Coagulation and Fibrinolysis - AMA Manual of Style
KAKEN - Researchers | SHIMENO Hiroshi (00078693)
JoVE Author Search: Selmeci L
Urokinase and its Receptor: Markers of Malignancy? | SpringerLink
Thrombin-Activatable Fibrinolysis Inhibitor | Bentham Science
Clot lysis time and thrombin activatable fibrinolysis inhibitor in severe preeclampsia with or without associated...
Thrombin activatable fibrinolysis inhibitor (tafi) at the interface between coagulation and fibrinolysis
DIGITAL.CSIC: Structure of Activated Thrombin-Activatable Fibrinolysis Inhibitor, a Molecular Link between Coagulation and...
Thrombin-activatable fibrinolysis inhibitor influences disease severity in humans and mice with pneumococcal meningitis -ORCA
The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media...
Fibrinolysis - Diapharma
Secretion and Antifibrinolytic Function of TAFI from Human Platelets
Tissue plasminogen activator antigen and coronary heart disease. Prospective study and meta-analysis. - MRCPHRU
Plasmin-antiplasmin system<...
Biochemical characterization of bovine plasma thrombin-activatable fibrinolysis inhibitor (TAFI) | BMC Biochemistry | Full Text
Fibrinolysis resistant fibrin deposits in lymph nodes with Hodgkins disease<...
Assay of procarboxypeptidase U, a novel determinant of the fibrinolytic cascade, in human plasma. - Free Online Library
Euglobulin Lysis Time [462n] - GBMC Test Dictionary
Effect of low-dose heparin treatment on fibrinolysis in patients with previous myocardial infarction
PRIME PubMed | Effect of second- and third-generation oral contraceptives on fibrinolysis in the absence or presence of the...
Anti-Human TAFI, Clone 1 - Molecular Innovations
Anti-Human TAFI, Clone 3 - Molecular Innovations
Vitamin C affects thrombosis/ fibrinolysis system and reactive hyperemia in patients with type 2 diabetes and coronary artery...
Endothelial fibrinolytic response onto an evolving matrix of fibrin | BMC Hematology | Full Text
Euglobulin lysis time | Health Encyclopedia | FloridaHealthFinder.gov
Gene Polymorphisms for Plasminogen Activator Inhibitor-1/Tissue Plasminogen Activator and Development of Allograft Coronary...
Thrombomodulin favors leukocyte microvesicle fibrinolytic activity, reduces NETosis and prevents septic shock-induced...
Angiotensin II Type 1 Receptor Antagonism Prevented the Effects of Hypercholesterolemia on Plasma Fibrinolytic Balance in...
Fibrinolysis in Multisystem Trauma Patients
Sparrho | Structures of potent selective peptide mimetics bound to ca
Effects of recombinant human activated protein C on the fibrinolytic system of patients undergoing conventional or tight...
The Effects of Age on Inflammatory and Coagulation-Fibrinolysis Response in Patients Hospitalized for Pneumonia
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Simultaneous thrombin and plasmin generation capacities in normal and abnormal states of coagulation and fibrinolysis in...
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Pathological haemostasis and prothrombotic state in Behcets disease | AVESİS
Distention during Surgical Preparation Impairs the Intrinsic Fibrinolytic Activity of Human Saphenous Vein | Clinical Science |...
Université Claude Bernard Lyon 1 - Comparison of primary angioplasty and pre-hospital fibrinolysis in acute myocardial...
Dr Nicola Mutch and Dr Claire Whyte win funding | British Society for Haemostasis & Thrombosis
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PLAT gene - Genetics Home Reference - NIH
Fibrinolytic variables are related to age, sex, blood pressure, and body build measurements: a cross-sectional study in Norsjö,...
Fibrin structure and mechanics: A journey across scales</em>...
Prevention of symptomatic thrombosis with short term (low molecular weight) heparin in patients with rheumatoid arthritis after...
Clotting Deficiency (Liver Related) in Cats | petMD
Fiziologichnyi Zhurnal
Anti-AnnexinII [ANEX 3D5/4] | Monoclonal Antibodies - Ximbio
Characterization of Shear-Sensitive Genes in the NormalRat Aorta Identifies Hand2 as a Major Flow-ResponsiveTranscription Factor
How Endovan works in endometriosis
Antithromboticthrombotic Monitoring - PDF
Tissue factor pathway inhibitor
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Reviparin sodium
Fibrinolysis. 4 Suppl 1: S55-8, discussion S59-60. PMID 8180331. Karsch KR, Preisack MB, Baildon R, Eschenfelder V, Foley D, ...
VLDL receptor
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Thrombodynamics test
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Ancrod
Impaired fibrinolysis. Severe liver disease. Manifest or impending shock. I.M.-Injection : Ancrod should not be injected i.m., ... acts as cofactor for the tPA-induced plasminogen activation and an increased fibrinolysis results in return (profibrinolytic ... viscoelastic analyses of the effects of Calloselasma rhodostoma venom on plasma coagulation and fibrinolysis". Journal of ...
Endothelium
Todd AS (February 1958). "Fibrinolysis autographs". Nature. 181 (4607): 495-6. Bibcode:1958Natur.181..495T. doi:10.1038/ ... thrombosis and fibrinolysis). The endothelium normally provides a surface on which blood does not clot, because it contains and ...
Factor XI
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FCGR3A
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Winged infusion set
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Acenocoumarol
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Hementin
Budzynski, A. Z. (February 1991). "Interaction of hementin with fibrinogen and fibrin". Blood Coagulation & Fibrinolysis. 2 (1 ... Fibrinolysis. DOI: 10.1097/00001721-199102000-00023 (1): 153-9. doi:10.1097/00001721-199102000-00023. PMID 1772983. "UniProtKB ...
Tenecteplase
Fibrinolysis. 16 (1): 1-7. doi:10.1097/00001721-200501000-00001. PMID 15650539. S2CID 44664652. Melzer C, Richter C, Rogalla P ...
C5orf34
Fibrinolysis. 19 (7): 709-718. doi:10.1097/MBC.0b013e32830b2891. PMC 2713681. PMID 18832915. "Genomatix: Annotation & Analysis ...
Kadmon Corporation
Fibrinolysis. 19 (7): 709-18. doi:10.1097/MBC.0b013e32830b2891. PMC 2713681. PMID 18832915. Lee, J; Zheng, Y; -von Bornstadt, D ...
Brodifacoum
Franco, David; Everett, George; Manoucheri, Manoucher (2013). "I smell a rat". Blood Coagulation & Fibrinolysis. 24 (2): 202-4 ...
Dilute Russell's viper venom time
Marsh, NA (July 1998). "Use of snake venom fractions in the coagulation laboratory". Blood Coagulation & Fibrinolysis. 9 (5): ... Fibrinolysis. 1 (3): 259-66. doi:10.1097/00001721-199008000-00002. PMID 2129412. Laboratory testing for the lupus anticoagulant ...
Factor IX
Fibrinolysis. 14 Suppl 1: S59-64. doi:10.1097/00001721-200306001-00014. PMID 14567539. Du X (May 2007). "Signaling and ...
D-dimer
The circulating enzyme plasmin, the main enzyme of fibrinolysis, cleaves the fibrin gel in a number of places. The resultant ... a small protein fragment present in the blood after a blood clot is degraded by fibrinolysis. It is so named because it ... Fibrinolysis. 27 (5): 542-50. doi:10.1097/MBC.0000000000000453. PMC 4935535. PMID 26656897. Olson JD, Cunningham MT, Higgins RA ...
Protein C inhibitor
Suzuki K (1 March 2000). "Protein C inhibitor (PAI-3): structure and multi-function". Fibrinolysis and Proteolysis. 14 (2): 133 ... Fibrinolysis. 4 (1): 153-8. doi:10.1097/00001721-199304010-00027. PMID 8384496. Moore A, Penfold LM, Johnson JL, Latchman DS, ... Fibrinolysis. 6 (5): 382-7. doi:10.1097/00001721-199507000-00003. PMID 8589203. The MEROPS online database for peptidases and ... Fibrinolysis. 4 (6): 921-6. doi:10.1097/00001721-199304060-00009. PMID 8148485. Hayashi T, Suzuki K (October 1993). "Gene ...
Acquired haemophilia
Blood Coagul Fibrinolysis. 2009; 20: 517-23. Delgado J, Jiménez-Yuste V, Hernández-Navarro F, Villar A. Acquired haemophilia: ...
Staphylokinase
Vanderschueren S, Van de Werf F, Collen D (August 1997). "Recombinant staphylokinase for thrombolytic therapy". Fibrinolysis ...
Anticoagulant
Fibrinolysis. 27 (3): 242-245. doi:10.1097/MBC.0000000000000427. ISSN 0957-5235. PMID 27023878. S2CID 33380206. "Avocado: ...
Contact activation system
Blood Coagul Fibrinolysis. 5 (5): 671-8. PMID 7507361. Rasmus KBJKJER and Inger SCHOUSBOE (1997). "The surface-dependent ...
Thrombus
This is due to excessive consumption of coagulation factors and subsequent activation of fibrinolysis using all of the body's ... Budzynski, A. Z. (1991). "Interaction of hementin with fibrinogen and fibrin". Blood Coagulation & Fibrinolysis. 2 (1): 149-52 ...
Phlegmasia cerulea dolens
Fibrinolysis. 25 (5): 507-511. doi:10.1097/MBC.0000000000000057. ISSN 1473-5733. PMID 24553060. Chinsakchai, Khamin; ten Duis, ... Fibrinolysis. 25 (5): 507-511. doi:10.1097/MBC.0000000000000057. ISSN 1473-5733. PMID 24553060. Gardella, Layne; Faulk, JimBob ... Fibrinolysis. 25 (5): 507-511. doi:10.1097/MBC.0000000000000057. ISSN 1473-5733. PMID 24553060. Gardella, Layne; Faulk, JimBob ...
Platelet
Fibrinolysis. 24 (5): 484-8. doi:10.1097/MBC.0b013e32835e4230. PMID 23348429. S2CID 31284130. Kornerup KN, Page CP (August 2007 ...
Belumosudil
Fibrinolysis. 19 (7): 709-18. doi:10.1097/MBC.0b013e32830b2891. PMC 2713681. PMID 18832915. Park J, Chun KH (5 May 2020). " ...
Coagulation
FibrinolysisEdit. Main article: Fibrinolysis. Eventually, blood clots are reorganised and resorbed by a process termed ... Tranexamic acid and aminocaproic acid inhibit fibrinolysis and lead to a de facto reduced bleeding rate. Before its withdrawal ... fibrinolysis. The main enzyme responsible for this process (plasmin) is regulated by various activators and inhibitors.[12] ...
Craterellus lutescens
Blood Coagulation and Fibrinolysis. 12 (2): 123-8. doi:10.1097/00001721-200103000-00006. PMID 11302474. S2CID 28411589. ...
Developmental Haemostasis
Blood Coagulation and Fibrinolysis. 22(2): 110-7 (2011). Ignjatovic V, Straka E, Summerhayes R, Monagle P. Age-specific ...
Fibrinolysis - Wikipedia
... primary fibrinolysis and secondary fibrinolysis. The primary type is a normal body process, whereas secondary fibrinolysis is ... Testing of overall fibrinolysis can be measured by a euglobulin lysis time (ELT) assay. The ELT measures fibrinolysis by ... In this assay, increased fibrinolysis is assessed by comparing the TEM profile in the absence or presence of the fibrinolysis ... In fibrinolysis, a fibrin clot, the product of coagulation, is broken down.[2] Its main enzyme plasmin cuts the fibrin mesh at ...
Exercise and Fibrinolysis | The BMJ
Blood Coagulation & Fibrinolysis
Fibrinolysis syndrome - Wikipedia
Fibrinolysis for Pulmonary Embolism Effective but Risky
Fibrinolysis - primary or secondary: MedlinePlus Medical Encyclopedia
Fibrinolysis is a normal body process. It prevents blood clots that occur naturally from growing and causing problems. ... Primary fibrinolysis refers to the normal breakdown of clots.. Secondary fibrinolysis is the breakdown of blood clots due to a ... Fibrinolysis is a normal body process. It prevents blood clots that occur naturally from growing and causing problems. ... Hemostasis, thrombosis, fibrinolysis, and cardiovascular disease. In: Zipes DP, Libby P, Bonow RO, Mann DL, Tomaselli GF, ...
Subscription Services : Blood Coagulation & Fibrinolysis
A heparinoid cream and tissue fibrinolysis. | The BMJ
Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis. - PubMed - NCBI
Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis.. Gaberel T1, Montagne A2, Lesept F2, Gauberti M2, ... Our study provides evidence supporting the use of uPA for fibrinolysis of IVH. A clinical trial could be warranted if tPA ... Intraventricular hemorrhage (IVH) is the most severe form of stroke with intraventricular fibrinolysis (IVF) as a hopeful ...
Impairment of Fibrinolysis as a Risk Factor for Thrombosis | SpringerLink
B. Wiman and D. Collen, Molecular mechanism of physiological fibrinolysis, Nature 272:549 (1978).PubMedCrossRefGoogle Scholar ... Collen D. (1984) Impairment of Fibrinolysis as a Risk Factor for Thrombosis. In: Chazov E.I., Smirnov V.N., Oganov R.G. (eds) ... T. Astrup, Biological significance of fibrinolysis, Lancet 2:565 (1956).CrossRefGoogle Scholar ... D. Collen, On the regulation and control of fibrinolysis, Thrombos.Haemostas. 43:77 (1980).Google Scholar ...
Clot Structure and Fibrinolysis in Thrombosis and Hemostasis
... Lead Guest Editor: Zsuzsa Bagoly. Guest Editors: Robert A. S. ... Inhibition of Fibrinolysis by Coagulation Factor XIII, Dingeman C. Rijken and Shirley Uitte de Willige Review Article (6 pages ... Clot Structure and Fibrinolysis in Thrombosis and Hemostasis, Zsuzsa Bagoly, Robert A. S. Ariëns, Dingeman C. Rijken, Marlien ... Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation, Noémi Klára Tóth, Zoltán Csanádi, ...
502360: Fibrinolysis Profile II (Esoterix) | LabCorp
2018 Laboratory Corporation of America® Holdings and Lexi-Comp Inc. All Rights Reserved.. CPT Statement/Profile Statement. The LOINC® codes are copyright © 1994-2018, Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. Permission is granted in perpetuity, without payment of license fees or royalties, to use, copy, or distribute the LOINC® codes for any commercial or non-commercial purpose, subject to the terms under the license agreement found at https://loinc.org/license/. Additional information regarding LOINC® codes can be found at LOINC.org, including the LOINC Manual, which can be downloaded at LOINC.org/downloads/files/LOINCManual.pdf. ...
Fibrinolysis Before Cardiopulmonary Bypass? - Full Text View - ClinicalTrials.gov
Fibrinolysis Before Cardiopulmonary Bypass?. The safety and scientific validity of this study is the responsibility of the ... The investigators want to show that there is no proof of fibrinolysis in standard sternotomy cardiac surgery patients before ... Value of Thromboelastography as Monitor of Fibrinolysis [ Time Frame: 6 months ]. Thromboelastography may display if ...
Current aspects of blood coagulation, fibrinolysis, and platelets (Book, 1993) [WorldCat.org]
... fibrinolysis, and platelets. [M -C Shen; C -M Teng; Akikazu Takada;] ... Fibrinolysis--congresses. a schema:Intangible ;. schema:name "Fibrinolysis--congresses"@en ;. schema:name "Fibrinolysis-- ... fibrinolysis_and_platelets_2nd_1992_taipei_taiwan> ; # Sino-Japanese Symposium on Coagulation, Fibrinolysis, and Platelets (2nd ... Current aspects of blood coagulation, fibrinolysis, and platelets. Author:. 高田, 明和, ; ; M -C Shen; C -M Teng; Akikazu Takada. ...
Intracardiac Hemostasis and Fibrinolysis Parameters in Patients with Atrial Fibrillation
RCPA - Fibrinolysis
JCI -
Fibrinolysis is essential for fracture repair and prevention of heterotopic ossification
Clinical Indicator | Fibrinolysis Therapy Received within 30 min of Arrival
The effect of intramuscular stanozolol on fibrinolysis and blood lipids
... on fibrinolysis, blood coagulation and lipids was evaluated in 12 healthy male volunteers. Significantly increased plasminogen ... The effect of intramuscular stanozolol on fibrinolysis and blood lipids Thromb Res. 1982 Oct 1;28(1):27-36. doi: 10.1016/0049- ... The effects of a single 50 mg intramuscular injection of the anabolic steroid stanozolol (Stromba) on fibrinolysis, blood ...
Progressive intermittent claudication is associated with impaired fibrinolysis.
Fibrinolysis / physiology*. Humans. Intermittent Claudication / blood, complications, physiopathology*. Leg / blood supply. ... 7667817 - Early markers of blood coagulation and fibrinolysis activation in argentine hemorrhagic.... 23168017 - Targeting ... the activator of fibrinolysis) and its inhibitor plasminogen activator inhibitor-1 (PAI-1).. METHODS: The study group consisted ... suggesting that the progression to more severe levels of PAD may be associated with worsening endogenous fibrinolysis.. ...
Intra-Arterial Fibrinolysis for Acute Ischemic Stroke | Stroke
Intra-Arterial Fibrinolysis for Acute Ischemic Stroke. The Message of Melt. Jeffrey L. Saver ... Meta-analysis: IA fibrinolysis for acute ischemic stroke, death or dependency at longterm follow-up. ... An updated meta-analysis of intra-arterial fibrinolysis trials incorporating MELT is shown in the Figure. Stopped early because ... In US national practice guidelines, intra-arterial fibrinolysis occupied a gray zone, receiving a Level B recommendation, ...
Fibrinolysis and Body Weight: Fibrinolytic Response to Venous Occlusion in Obese Children | SpringerLink
C.S. Grace and R.B. Goldrick, Fibrinolysis and body build. Interrelationships between blood, fibrinolysis, body composition and ... 1984) Fibrinolysis and Body Weight: Fibrinolytic Response to Venous Occlusion in Obese Children. In: Strano A. (eds) Thrombosis ... Fibrinolysis and Body Weight: Fibrinolytic Response to Venous Occlusion in Obese Children. ...
Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans | Diabetes
Hyperinsulinemia inhibits fibrinolysis irrespective of glucose levels. Mean ± SD plasma concentrations of tPA antigen (A), ... Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans. Michiel E. Stegenga, ... Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans. Michiel E. Stegenga, ... Hyperglycemia Stimulates Coagulation, Whereas Hyperinsulinemia Impairs Fibrinolysis in Healthy Humans Message Subject (Your ...
Vitronectin deficiency is associated with increased wound fibrinolysis and decreased microvascular angiogenesis in mice. -...
Pesticins III. Expression of Coagulase and Mechanism of Fibrinolysis | Journal of Bacteriology
The role of thrombin-activatable fibrinolysis inhibitor in diabetes mellitus
The Effects of Age on Inflammatory and Coagulation-Fibrinolysis Response in Patients Hospitalized for Pneumonia
2010) The Effects of Age on Inflammatory and Coagulation-Fibrinolysis Response in Patients Hospitalized for Pneumonia. PLoS ONE ... The differences in coagulation-fibrinolysis response that exist do not explain the large differences in outcome observed ... 1997) Interleukin-10 inhibits activation of coagulation and fibrinolysis during human endotoxemia. Blood 89: 2701-2705. * View ... We hypothesized that age-related increases in circulating inflammatory and coagulation-fibrinolysis response would occur ...
Clotting activation and impairment of fibrinolysis in malignancy
Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours ... Clotting activation and impairment of fibrinolysis in malignancy. Jun 15, 1989 , Magazine: Thrombosis Research ... This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in ...
Inhibition of Coagulation and Fibrinolysis - AMA Manual of Style
Association of pulse pressure with fibrinolysis in patients with type 2 diabetes.
... of this cross-sectional study was to determine whether pulse pressure is associated with blood coagulation and fibrinolysis in ... RESULTS: Pulse pressure was found to be significantly correlated with blood fibrinolysis markers, such as plasmin-alpha2- ... CONCLUSIONS: Pulse pressure is associated with blood fibrinolysis as well as atherosclerotic progression in patients with type ... including blood coagulation and fibrinolysis markers, were investigated in subjects with type 2 diabetes. ...
Coagulation and fibrinolysisTAFIActivation of coagulationEndogenousInhibitionHaemostasisImpairment of FibrinolysisPlasminogen activatorsPlasma thrombin-activatabVitroPlateletsAssociated with blood fibrinolysisLocal intraarterial fibrinolysisEnzyme-LinkePatientsInhibitor of fibrinolysisActivator of fibrinolysisResistant to fibrinolysisResistance to fibrinolysisBreakdown of fibrinTranexamic acidMyocardial infarctionFibrinogenThrombusActive fibrinolysisInhibits fibrinolysisSecondary fibrinolysisVascularTissueTAFIaUrokinaseHeparinClot lysisFingerprintPrimaryClinicalDissolutionEndothelialAtrial FibrillationBloodBiologicalDefectiveLevels of inflammatoryMechanisms
Coagulation and fibrinolysis26
- In this ancillary study, we will measure plasma levels of inflammatory, coagulation, and fibrinolysis proteins and genotype DNA for polymorphisms among patients enrolled in the HALF PINT trial. (clinicaltrials.gov)
- We will measure plasma levels of selected markers of coagulation and fibrinolysis and genotype DNA for polymorphisms in the corresponding genes. (clinicaltrials.gov)
- We will correlate changes over time in the biomarkers with allocation to treatment arm to test whether the beneficial effects of TGC-NL are achieved via normalization of coagulation and fibrinolysis. (clinicaltrials.gov)
- Different coagulation and fibrinolysis parameters were investigated in 149 patients with metastatic and non-metastatic tumours and results were compared with those obtained in a healthy population. (cun.es)
- The purpose of this cross-sectional study was to determine whether pulse pressure is associated with blood coagulation and fibrinolysis in patients with diabetes. (biomedsearch.com)
- MATERIALS AND METHODS: The relationships between pulse pressure and atherosclerotic risk factors, including blood coagulation and fibrinolysis markers, were investigated in subjects with type 2 diabetes. (biomedsearch.com)
- Disequilibrium between coagulation and fibrinolysis can lead to severe haemostatic disorders such as thrombosis and hemophilia. (queensu.ca)
- Coagulation and fibrinolysis are essential processes that ensure a rapid, localized response to vascular damage and subsequent removal once the damage is repaired. (queensu.ca)
- Thrombin-activatable fibrinolysis inhibitor (TAFI), which is identical to the previously identified proteins procarboxypeptidase B, R, and U, forms a link between blood coagulation and fibrinolysis. (eurekaselect.com)
- Serial changes in coagulation and fibrinolysis studied among 42 patients admitted to hospital with a wide variety of injuries are reported. (bmj.com)
- Anticoagulated COVID-19 patients have persistent in vivo activation of coagulation and fibrinolysis, but no evidence of excessive platelet activation. (unboundmedicine.com)
- TY - JOUR T1 - In vitro hypercoagulability and ongoing in vivo activation of coagulation and fibrinolysis in COVID-19 patients on anticoagulation. (unboundmedicine.com)
- Many investigators are interested in the relationship between mental stress and platelet function, coagulation and fibrinolysis [1, 2], since several lines of evidence suggest that atherosclerotic cardiovascular events may be related to mental stress. (springer.com)
- The initial observation that the fear of impending surgery increased fibrinolytic activitymade by Macfarlane and Biggs [10] Recently Jern et al [11] reported y the effects of mental stress on plasma coagulation and fibrinolysis. (springer.com)
- Jern C, Eriksson E, Tengborn L, Risberg B, Wadenvik H, Jern S (1989) Changes of plasma coagulation and fibrinolysis in response to mental stress. (springer.com)
- Blood coagulation and fibrinolysis of the newborn viewed äs perinatal factors. (hu-berlin.de)
- It is believed that abnormal coagulation and fibrinolysis is a frequent complication in patients with head injury, and this abnormality is initiated by the released of thromboplastin (tissue factor) from damaged brain. (biomedcentral.com)
- But some authors [ 1 , 2 ] reported that the activation of coagulation and fibrinolysis after head injury is not the specific phenomenon comparing with the population of trauma victim. (biomedcentral.com)
- Recently, we have been able to measure some molecular markers of coagulation and fibrinolysis system in clinical setting. (biomedcentral.com)
- We compared coagulation and fibrinolysis activity of trauma and head injury patients using the molecular markers. (biomedcentral.com)
- HI and TR had significantly activation of coagulation and fibrinolysis compared with CVD, but there were no evidence that HI had significantly activation of coagulation and fibrinolysis compared with TR. (biomedcentral.com)
- Gando S, Tedo I, Kubota M: Posttrauma coagulation and fibrinolysis. (biomedcentral.com)
- Arthritis is linked to local and systemic activation of coagulation and fibrinolysis pathways. (semanticscholar.org)
- BACKGROUND Activation of coagulation and fibrinolysis play a role in the pathophysiology of experimental arthritis. (semanticscholar.org)
- Hankey, C.R. , Lean, M.E.J. , Lowe, G.D.O. , Rumley, A. and Woodward, M. (2002) Effects of moderate weight loss on anginal symptoms and indices of coagulation and fibrinolysis in overweight patients with angina pectoris. (gla.ac.uk)
- For more information see ADIC / Disseminated Intravascular Coagulation/Intravascular Coagulation and Fibrinolysis (DIC/ICF) Profile, Plasma. (testcatalog.org)
TAFI10
- Plasmin activity is also reduced by thrombin-activatable fibrinolysis inhibitor (TAFI), which modifies fibrin to make it more resistant to the tPA-mediated plasminogen. (wikipedia.org)
- Thrombin-activable fibrinolysis inhibitor (TAFI) is a carboxypeptidase B-like pro-enzyme that, once activated, attenuates fibrinolysis. (queensu.ca)
- Abstract -Thrombin-activatable fibrinolysis inhibitor (TAFI) is a recently described fibrinolysis inhibitor that circulates in plasma as a procarboxypeptidase and is converted into an active form during coagulation. (ahajournals.org)
- Thrombin-activatable fibrinolysis inhibitor (TAFI) is a recently described fibrinolysis inhibitor cloned from human liver. (ahajournals.org)
- D-Dimers, thrombin-activatable fibrinolysis inhibitor (TAFI) and the clot lysis time in the absence (LYSmin) or the presence (LYSplus) of a blocking anti-factor XI antibody were determined in plasmas of the participating women, and the mean difference in changes between the OC were calculated. (unboundmedicine.com)
- The aim of the present study is to investigate the effect of gestational diabetes on plasma thrombin-activatable fibrinolysis inhibitor (TAFI) antigen levels. (endocrine-abstracts.org)
- The purpose of this study was to investigate plasma levels of thrombin activatable fibrinolysis inhibitor (TAFI) and TAFI's relationship with coagulation markers (prothrombin fragment 1 + 2) in gastric cancer patients. (springermedizin.de)
- Bajzar L, Manuel R, Nesheim ME: Purification and characterization of TAFI, a thrombin-activable fibrinolysis inhibitor. (springermedizin.de)
- Impaired fibrinolysis in subjects with hypertriglyceridemia/low HDL-cholesterol is associated with increased serum levels of PAI-1 whereas enhanced thrombin generation and TAFI hyperactivity are the main findings in hypercholesterolemia. (mysciencework.com)
- For maintaining high fidelity regulation between coagulatory clotting and proteolytic fibrinolysis TAFI (Thrombin activatable fibrinolysis inhibitor) plays an important inhibitory role. (diapharma.com)
Activation of coagulation1
- Hyperglycemia is known to result in a pro-thrombotic state via activation of coagulation and impairment of fibrinolysis. (clinicaltrials.gov)
Endogenous8
- Patients with SC had more impaired fibrinolytic activity than those with MC and the control subjects, suggesting that the progression to more severe levels of PAD may be associated with worsening endogenous fibrinolysis. (biomedsearch.com)
- Impaired endogenous fibrinolysis at high shear using a point-of-care test in STEMI is associated with alterations in clot architecture. (bioportfolio.com)
- Impaired endogenous fibrinolysis is an adverse prognostic biomarker in acute coronary syndrome (ACS). (bioportfolio.com)
- In contrast, endogenous fibrinolysis, using one-thousandth of the t-PA concentration, is regularly lysing fibrin and induced Thrombolysis In Myocardial Infarction flow grade 3 patency in 15% of patients with acute myocardial infarction. (onlinejacc.org)
- Endogenous fibrinolysis may provide a paradigm that is relevant for therapeutic fibrinolysis. (onlinejacc.org)
- Improved endogenous fibrinolysis and endothelial function may represent important mechanisms through which ω-3 fatty acids confer potential cardiovascular benefits. (bmj.com)
- Inhibition of PN-1 is thus predicted to promote endogenous and exogenous tissue plasminogen activator-mediated fibrinolysis and may enhance the therapeutic efficacy of thrombolytic agents. (inserm.fr)
- The endogenous plasmin-mediated process of dissolving a formed thrombus is denoted fibrinolysis. (diapharma.com)
Inhibition3
- In conclusion, anti-plasminogen and anti-tPA antibodies occur in AAV and associate with functional inhibition of fibrinolysis in vitro . (asnjournals.org)
- Wang W, Boffa MB, Bajzar L, Walker JB, Nesheim ME: A study of the mechanism of inhibition of fibrinolysis by activated thrombin-activable fibrinolysis inhibitor. (springermedizin.de)
- It goes on to discuss local fibrinolytic potential in thrombi, both venous and arterial, and in the diseased vessel wail, presenting evidence that increased local inhibition of fibrinolysis by PAI-1, PAI-2 and alpha(2)-antiplasmin is intimately involved in thrombus stability and in the generation of fibrin-rich vessel wall lesions. (elsevier.com)
Haemostasis2
- The journal is devoted to publishing significant developments worldwide in the field of blood coagulation, fibrinolysis, thrombosis, platelets and the kininogen-kinin system, as well as dealing with those aspects of blood rheology relevant to haemostasis and the effects of drugs on haemostatic components. (ovid.com)
- Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis, vol. 13, no. 5, 2002, pp. 373-81. (unboundmedicine.com)
Impairment of Fibrinolysis1
- This study demonstrates clotting activation, at the level of fibrinogen to fibrin conversion, and impairment of fibrinolysis in patients with malignancy. (cun.es)
Plasminogen activators3
- This study examined fibrin degradation by measuring D-dimer crosslinked fibrin degradation products (indicates hypercoagulability), plasminogen activators (fibrinolysis), and antithrombin III in 42 adult trauma patients and correlated these data with injury severity, types of injury, complications, and clinical tests of coagulation. (ovid.com)
- There are 2 plasminogen activators in the blood responsible for fibrinolysis: tissue-type plasminogen activator (t-PA) and urokinase plasminogen activator (uPA). (onlinejacc.org)
- We work with several global collaborators to study fundamental questions around the regulation of enzymes used as plasminogen activators that promote fibrinolysis. (nibsc.org)
Plasma thrombin-activatab1
- Increased plasma thrombin-activatable fibrinolysis inhibitor levels in young obese women with polycystic ovary syndrome. (semanticscholar.org)
Vitro8
- Doppler sonography enhances rtPA-induced fibrinolysis in an in vitro clot model of spontaneous intracerebral hemorrhages. (bioportfolio.com)
- The aim of this study was to assess the potential of TCD to enhance rtPA-induced fibrinolysis in an in vitro clot system. (bioportfolio.com)
- Eighteen of 74 AAV-IgG (but no control IgG) retarded fibrinolysis in vitro , and this associated with anti-plasminogen and/or anti-tPA antibody positivity. (asnjournals.org)
- In conclusion, human arterial SMC in vitro induce fibrinolysis by activation of plasminogen. (ahajournals.org)
- The in vitro and in vivo hematological effects of puff adder (Bitis arietans) venom in the baboon (Papio ursinus) with regard to its effect on coagulation, fibrinolysis and platelet aggregation were studied. (sun.ac.za)
- There is a delay in the intrinsic coagulation mechanism with fibrinolysis and in vitro fibrinogenolysis. (sun.ac.za)
- A wide array of in vitro fibrinolysis tests had been performed for a long period, suggesting defective fibrinolysis, mainly impaired tPA response and reserve as major, frequent abnormality, predecessor or causative factor of venous thromboembolism. (elsevier.com)
- Both in vitro and in vivo, tPA and prouPA have complementary modes of action in fibrinolysis are synergistic when combined. (heraldopenaccess.us)
Platelets5
- The first Sino-Japanese symposium on Coagulation, Fibrinolysis and Platelets, originating from the Hamamatsu symposium, held in early 1990, was held in Hanchow, Mainland China in October, 1990. (worldcat.org)
- RESULTS: Pulse pressure was found to be significantly correlated with blood fibrinolysis markers, such as plasmin-alpha2-antiplasmin complex (PAP) and D-dimer, but not with platelets and blood coagulation markers, such as fibrinogen and thrombin-antithrombin III complex (TAT). (biomedsearch.com)
- The body is often accompanied by hypoxia and injury of small blood vessel endothelial cells, as well as abnormalities in functions such as coagulation, fibrinolysis, and platelets. (scirp.org)
- Thrombin has been the primary target to attenuate the procoagulant response associated with fibrinolysis, because it activates platelets, converts fibrinogen to fibrin, and binds to clots. (aspetjournals.org)
- Methods and Results- In this study, the role of platelet PN-1 in fibrinolysis was investigated with the use of human platelets incubated with a blocking antibody and platelets from PN-1-deficient mice. (inserm.fr)
Associated with blood fibrinolysis1
- CONCLUSIONS: Pulse pressure is associated with blood fibrinolysis as well as atherosclerotic progression in patients with type 2 diabetes. (biomedsearch.com)
Local intraarterial fibrinolysis2
- At the time, there was limited experience using fibrinolytic agents other than urokinase for local intraarterial fibrinolysis in cases of basilar thrombosis or acute thromboembolic stroke (11-19) . (ajnr.org)
- Several open-label clinical studies using continuous infusion of thrombolytic agents have suggested that local intraarterial fibrinolysis (LIF) is efficacious in the treatment of central retinal artery occlusion. (ahajournals.org)
Enzyme-Linke1
- The deep veins of both lower limbs were examined by Rili Erlangshen's color Doppler ultrasound diagnostic instrument (CDU), and the fibrinolysis system was tested by enzyme-linked immunosorbent assay (ELISA) method and automatic hemagglutination analyzer. (scirp.org)
Patients20
- Clinically, the TEM is useful for near real-time measurement of activated fibrinolysis for at-risk patients, such as those experiencing significant blood loss during surgery. (wikipedia.org)
- The investigators want to show that there is no proof of fibrinolysis in standard sternotomy cardiac surgery patients before cardiopulmonary bypass, and that antifibrinolytic agents should only be started on cardiopulmonary bypass. (clinicaltrials.gov)
- Association of pulse pressure with fibrinolysis in patients with type 2 diabetes. (biomedsearch.com)
- Hypercoagulability and suppression of fibrinolysis were seen in most patients and were not correlated with severity of injury. (ovid.com)
- Latex agglutination of D-dimer provides a rapid test of fibrinolysis that may be clinically useful in the management of trauma patients who cannot be easily studied for thrombosis. (ovid.com)
- Fibrinolysis with local intraarterial urokinase infusion for basilar artery thrombosis has been associated with a low rate of spontaneous symptomatic cerebral hemorrhage, even when patients have been treated late in the course of symptoms. (ajnr.org)
- 0.001) in the group of patients when compared to controls, indicating a degree of fibrinolysis/proteolysis activation. (cun.es)
- We conclude that there is a disturbance of the plasma fibrinolysis/proteolysis in patients with stable angina not related to the extent of atherosclerosis. (cun.es)
- Objective To understand more about the individual variation in the time course of fibrinolysis following major injury and to assess the potential for stratification of trauma patients for tranexamic acid (TXA) therapy. (bmj.com)
- However, it is unknown whether TCD would be suitable to enhance rtPA-induced fibrinolysis in patients with ICH. (bioportfolio.com)
- Borzak S. Early transfer for angiography after fibrinolysis reduced ischemic events in patients with STEMI. (annals.org)
- Longitudinally Measured Fibrinolysis Factors are Strong Predictors of Clinical Outcome in Patients with Chronic Heart Failure: The Bio-SHiFT Study. (medworm.com)
- Conceivably, therapies that enhance fibrinolysis might benefit a subset of AAV patients. (asnjournals.org)
- 7 , 8 Under these circumstances, down-regulation of fibrinolysis by anti-plasminogen antibodies in AAV patients would promote persistent or extensive fibrinoid necrosis. (asnjournals.org)
- We show that Ig from AAV patients retards fibrinolysis and that seropositivity for these antibodies correlates with reduced renal function and the presence of hallmark histopathologic renal lesions. (asnjournals.org)
- We studied 24 patients who were diagnosed to have F1GO stage Ill/IV ovarian cancer compared to nine subjects with FIGO Stage I/II disease for their systemic levels of fibrinolysis and inhibitors. (nus.edu.sg)
- Effects of atorvastatin on reactive hyperaemia and the thrombosis-fibrinolysis system in patients with heart failure. (ox.ac.uk)
- OBJECTIVE: To investigate the effects of short term atorvastatin treatment on forearm vasodilatory response to reactive hyperaemia (RH%) and on components of the thrombosis-fibrinolysis system (antithrombin III, proteins and S, factors V and VII, von Willebrand factor, tissue plasminogen activator (tPA), and plasminogen activator inhibitor (PAI-1)) in patients with heart failure. (ox.ac.uk)
- Therefore, short term treatment with atorvastatin may affect the expression of both endothelium and liver derived components of the thrombosis-fibrinolysis system in patients with heart failure. (ox.ac.uk)
- Since these are among the commonest causes of morbidity and mortality worldwide, for the majority of patients only more effective and safer fibrinolysis can provide sufficiently timely reperfusion. (heraldopenaccess.us)
Inhibitor of fibrinolysis2
- as a natural inhibitor of fibrinolysis) and D-dimer (as a marker of the extent of fibrinolysis). (bmj.com)
- By double immunofluorescent labelling systems fibrin deposits were simultaneously stained for α 2 -antiplasmin (α 2 -AP), the main physiological inhibitor of fibrinolysis and in a number of nodular areas they were also labelled for plasmin(ogen). (elsevier.com)
Activator of fibrinolysis1
- The current study was performed to determine whether peripheral arterial disease (PAD) and its progression are also associated with impaired fibrinolysis, by measurement of tissue plasminogen activator (tPA, the activator of fibrinolysis) and its inhibitor plasminogen activator inhibitor-1 (PAI-1). (biomedsearch.com)
Resistant to fibrinolysis1
- In this study we provide immunomorphological evidence showing that fibrin deposits in lymph nodes with Hodgkin's disease are stabilized and made resistant to fibrinolysis by factor XIII (FXIII) of blood coagulation. (elsevier.com)
Resistance to fibrinolysis3
- The impact of cross-linking on resistance to fibrinolysis has proved challenging to evaluate quantitatively. (wiley.com)
- Although very low levels of FXIII are known to produce mechanical clot stability, and to achieve γ-dimerization, they appear to be suboptimal in conferring full resistance to fibrinolysis. (wiley.com)
- Its release is concentrated to platelet rich clots leading to an increased thrombus resistance to fibrinolysis. (diapharma.com)
Breakdown of fibrin1
- Fibrinolysis is the enzymatic breakdown of fibrin in blood clots. (diapharma.com)
Tranexamic acid1
- What concentration of tranexamic acid is needed to inhibit fibrinolysis? (bioportfolio.com)
Myocardial infarction4
- Therapeutic fibrinolysis has been dominated by the experience with tissue-type plasminogen activator (t-PA), which proved little better than streptokinase in acute myocardial infarction. (onlinejacc.org)
- We present the first documented case of intraosseous systemic fibrinolysis in a patient with ST-segment elevation myocardial infarction. (ivteam.com)
- Rescue angioplasty or repeat fibrinolysis after failed fibrinolytic therapy for ST-segment myocardial infarction: a meta-analysis of randomized trials. (acpjc.org)
- Impaired fibrinolysis is believed to promote atherosclerosis and contribute to myocardial infarction. (ahajournals.org)
Fibrinogen2
- The ELT measures fibrinolysis by clotting the euglobulin fraction (primarily the important fibrinolytic factors fibrinogen , PAI-1 , tPA , alpha 2-antiplasmin , and plasminogen ) from plasma and then observing the time required for clot dissolution. (wikipedia.org)
- Model thrombi, which mimic arterial thrombi formed in vivo , were prepared with incorporated fluorescently labeled fibrinogen, in order to allow quantification of fibrinolysis as released fluorescence units per minute. (wiley.com)
Thrombus3
- Agents that prevent fibrinolysis or lysis of a blood clot or thrombus. (bioportfolio.com)
- The only pharmacological means to remove the thrombus is fibrinolysis. (onlinejacc.org)
- Hence, this jet is expected to promote fibrinolysis by means of injecting fibrinolytics deeply into the thrombus . (curehunter.com)
Active fibrinolysis2
- This effect can be seen in the thrombin clotting time (TCT) test, which is prolonged in a person that has active fibrinolysis. (wikipedia.org)
- A prematurely active fibrinolysis could endanger the important acute clot stability. (diapharma.com)
Inhibits fibrinolysis2
- Hyperinsulinemia inhibits fibrinolysis irrespective of glucose levels. (diabetesjournals.org)
- The active form, TAFIa, inhibits fibrinolysis by cleaving off C-terminal lysine residues from partially degraded fibrin that stimulates the tissue-type plasminogen activator-mediated conversion of plasminogen to plasmin. (eurekaselect.com)
Secondary fibrinolysis2
- [1] This process has two types: primary fibrinolysis and secondary fibrinolysis. (wikipedia.org)
- The primary type is a normal body process, whereas secondary fibrinolysis is the breakdown of clots due to a medicine, a medical disorder, or some other cause. (wikipedia.org)
Vascular2
- The major triggering factor for fibrinolysis is vascular tissue plasminogen activator (t-PA), and the aim of this study was to evaluate the capacity of human arterial smooth muscle cells (SMC) for induction of fibrinolysis. (ahajournals.org)
- Fibrinolysis is the body's natural defense that prevents physiological fibrin, needed for the repair of wear and tear vascular injuries, from building up and interfering with blood flow. (heraldopenaccess.us)
Tissue9
- Tissue plasminogen activator (t-PA) [3] and urokinase are the agents that convert plasminogen to the active plasmin, thus allowing fibrinolysis to occur. (wikipedia.org)
- A heparinoid cream and tissue fibrinolysis. (bmj.com)
- Risberg B , Peterson H I . A heparinoid cream and tissue fibrinolysis. (bmj.com)
- Because urokinase is presently unavailable in the United States, this study was undertaken to determine the frequency of spontaneous cerebral hemorrhage in basilar artery fibrinolysis performed with tissue plasminogen activator (tPA). (ajnr.org)
- Fibrinolysis was induced with recombinant human tissue-type plasminogen activator (1.0 mg/kg i.v. over 1 h), and patency was monitored continuously for 24 h with an implanted Doppler probe. (aspetjournals.org)
- 6 RCTs ( n = 908, mean age range 57 to 63 y, 76% men) of rescue PCI and 3 RCTs ( n = 410, mean age range 56 to 63 y, 75% men) of repeated fibrinolysis (with tissue-type plasminogen activator) met the selection criteria. (acpjc.org)
- Fibrinolysis initiation is mainly dependent on the tissue-type plasminogen activator ( t-PA ). (diapharma.com)
- Fibrinolysis plays a role as well in other biological processes such as tissue repair, macrophage activation and function, ovulation, and embryo implantation. (perfusion.com)
- Tissue plasminogen activator (tPA) is a serine protease found on endothelial cells (cells that line the blood vessels) involved in the breakdown of blood clots ( fibrinolysis ). (diapharma.com)
TAFIa3
- Thrombin activatable fibrinolysis inhibitor (TAFIa) suppresses fibrinolysis by removing carboxyl-terminal lysine residues exposed by plasmin (Pn) on fibrin. (queensu.ca)
- These data identified new mechanisms in which TAFIa can attenuate fibrinolysis. (queensu.ca)
- An update on the role of carboxypeptidase U (TAFIa) in fibrinolysis. (semanticscholar.org)
Urokinase3
- Urokinase versus Alteplase for intraventricular hemorrhage fibrinolysis. (nih.gov)
- Despite delays in diagnosis and treatment common in this condition, fibrinolysis with urokinase has had an acceptable safety profile, especially in view of the high mortality rate associated with conservative treatment. (ajnr.org)
- Beginning in April 1999, tPA was substituted for urokinase for intraarterial fibrinolysis in cases of acute thromboembolic stroke. (ajnr.org)
Heparin2
- Reocclusion occurred in all control and heparin/aspirin-treated dogs within 1 h after fibrinolysis. (aspetjournals.org)
- In minimal amounts there is evidence of consumption of blood coagulation factors with sustained thrombocytopenia, but no fibrinolysis, where heparin therapy might have a beneficial effect. (sun.ac.za)
Clot lysis2
- The first hours after trauma are dominated by an acceleration of fibrinolysis (clot lysis) and clotting time which are often followed by an abrupt rebound to prolonged fibrinolysis and normal clotting. (bmj.com)
- We have investigated the effects of DNA and histones on fibrinolysis and proposed that these highly charged molecules are able to hold the fibrin network together and retard clot lysis. (nibsc.org)
Fingerprint1
- Fingerprint Dive into the research topics of 'Fibrinolysis és érbetegségek. (elsevier.com)
Primary2
- Primary fibrinolysis refers to the normal breakdown of clots. (medlineplus.gov)
- Primary fibrinolysis is a normal body process. (diapharma.com)
Clinical5
- As a result, t-PA became essentially equated with fibrinolysis, as shown by it frequently not being identified specifically in publications on clinical fibrinolysis. (onlinejacc.org)
- These new actors and concepts in plasminogen activation represent hitherto unknown pathways in our comprehension of fibrinolysis and potential novel biomarkers in clinical practice. (inserm.fr)
- Booth, NA 1999, ' Fibrinolysis and thrombosis ', Best Practice & Research Clinical Obstetrics & Gynaecology , vol. 12, pp. 423-433. (elsevier.com)
- OBJECTIVE To evaluate carotid intima-media thickness and thrombin-activatable fibrinolysis inhibitor levels in young women with polycystic ovary syndrome (PCOS) and age-matched healthy controls, and to investigate their relationship with each other and with clinical, metabolic, and hormonal parameters. (semanticscholar.org)
- The fibrinolytic clinical experience has been with tPA monotherapy almost exclusively and this has been sufficiently disappointing that fibrinolysis has become discredited. (heraldopenaccess.us)
Dissolution2
- Fibrinolysis involves dissolution of polymeric fibrin networks that is required to restore blood flow through vessels obstructed by thrombi. (bioportfolio.com)
- Fibrinolysis Fibrinolysis is the dissolution of the clot formation process involving the plasma protein plasminogen. (perfusion.com)
Endothelial2
- There are two pathways in the fibrinolysis system: the intrinsic pathway initiates upon the activation of a coagulation factor XII to XIIa in its interaction with a negatively charged foreign surface in the presence of high molecular weight kininogen and prekallikrein, and the other pathway, extrinsic pathway, initiates by PAs introduced in the blood exogenously from endothelial cells or upon the addition of bacterial activators such as streptokinase (SK). (springer.com)
- Objective The effects of ω-3 fatty acids on endothelial function, fibrinolysis and platelet function are uncertain. (bmj.com)
Atrial Fibrillation1
- Prothrombin fragment F1 + 2 and thrombin-antithrombin III complex are useful markers of the hypercoagulable state in atrial fibrillation," Blood Coagulation & Fibrinolysis , vol. 3, no. 4, pp. 469-473, 1992. (hindawi.com)
Blood13
- Fibrinolysis is a process that prevents blood clots from growing and becoming problematic. (wikipedia.org)
- Fibrinolysis syndrome is characterized by an acute hemorrhagic state brought about by inability of the blood to clot, with massive hemorrhages into the skin producing blackish, purplish swellings and sloughing. (wikipedia.org)
- The cause for Fibrinolysis syndrome, is the inability of the body to produce blood-coagulates to stop bleeding. (wikipedia.org)
- New subscriptions to Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins (LWW) online store. (lww.com)
- Subscription renewals for Blood Coagulation & Fibrinolysis are managed through Lippincott Williams & Wilkins online store. (lww.com)
- S. Isacson and I. M. Nilsson, Defective fibrinolysis in blood and vein walls in recurrent "idiopathic" venous thrombosis, Acta Chir.Scand. (springer.com)
- The effects of a single 50 mg intramuscular injection of the anabolic steroid stanozolol (Stromba) on fibrinolysis, blood coagulation and lipids was evaluated in 12 healthy male volunteers. (nih.gov)
- Interrelationships between blood, fibrinolysis, body composition and parameters of lipid and carbohydrate metabolism. (springer.com)
- Blood clot contraction differentially modulates internal and external fibrinolysis. (bioportfolio.com)
- Deep vein CDU examination of both lower extremities combined with blood fibrinolysis monitoring is of great value in the prevention and treatment of hypertension during pregnancy. (scirp.org)
- Fibrinolysis is a system in which fibrin clot dissolves due to the degradation of fibrin by plasmin, which is present in the blood as a precursor form, plasminogen (plg). (springer.com)
- Fibrinolysis is a normal body process that keeps naturally occurring blood clots from growing and causing problems. (drugster.info)
- D-dimer (D dimer, DDimer) is a specific fibrin degradation product (FDP) generated after a blood clot is degraded by fibrinolysis . (diapharma.com)
Biological1
- By contrast to tPA mono-therapy, natural fibrinolysis uses a sequential combination of both biological activators, tPA and uPA, the native form of which is a proenzyme, prouPA. (heraldopenaccess.us)
Defective1
- Finally, it reviews the evidence that defective plasma fibrinolysis has a causal role in venous and arterial thrombosis. (elsevier.com)
Levels of inflammatory1
- Animal and human experimental models of infection also suggest that older subjects have higher circulating levels of inflammatory and coagulation-fibrinolysis response. (plos.org)
Mechanisms1
- Two parallel lines of investigation elucidating novel mechanisms by which iron (scanning electron microscopy-based) and carbon monoxide (viscoelastic-based) enhance coagulation and diminish fibrinolysis have emerged over the past few years. (up.ac.za)