Substances used to cause adherence of tissue to tissue or tissue to non-tissue surfaces, as for prostheses.
An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product is a two component system from human plasma that contains more than fibrinogen and thrombin. The first component contains highly concentrated fibrinogen, FACTOR VIII, fibronectin, and traces of other plasma proteins. The second component contains thrombin, calcium chloride, and antifibrinolytic agents such as APROTININ. Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING.
A group of compounds having the general formula CH2=C(CN)-COOR; it polymerizes on contact with moisture; used as tissue adhesive; higher homologs have hemostatic and antibacterial properties.
A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.
A tissue adhesive that is applied as a monomer to moist tissue and polymerizes to form a bond. It is slowly biodegradable and used in all kinds of surgery, including dental.
The practice of prescribing or using a drug outside the scope of the drug's official approved label as designated by a regulatory agency concerning the treatment of a particular disease or condition.
Torn, ragged, mangled wounds.
A puncture or hole through the CORNEAL STROMA resulting from various diseases or trauma.
Loss of epithelial tissue from the surface of the cornea due to progressive erosion and necrosis of the tissue; usually caused by bacterial, fungal, or viral infection.
Partial or total replacement of the CORNEA from one human or animal to another.
Partial or total replacement of all layers of a central portion of the cornea.
A noninflammatory, usually bilateral protrusion of the cornea, the apex being displaced downward and nasally. It occurs most commonly in females at about puberty. The cause is unknown but hereditary factors may play a role. The -conus refers to the cone shape of the corneal protrusion. (From Dorland, 27th ed)
Opportunistic fungal infection by a member of ALTERNARIA genus.
The lamellated connective tissue constituting the thickest layer of the cornea between the Bowman and Descemet membranes.
A subspecialty of otolaryngology dealing with the parts of the nervous system related to the ear.
A surgical specialty concerned with the study and treatment of disorders of the ear, nose, and throat.
The state of being free from intrusion or disturbance in one's private life or affairs. (Random House Unabridged Dictionary, 2d ed, 1993)
The privacy of information and its protection against unauthorized disclosure.
Protective measures against unauthorized access to or interference with computer operating systems, telecommunications, or data structures, especially the modification, deletion, destruction, or release of data in computers. It includes methods of forestalling interference by computer viruses or so-called computer hackers aiming to compromise stored data.
Pathological processes of the ear, the nose, and the throat, also known as the ENT diseases.
Voluntary authorization, by a patient or research subject, with full comprehension of the risks involved, for diagnostic or investigative procedures, and for medical and surgical treatment.
Agents used to occlude dental enamel pits and fissures in the prevention of dental caries.
Activity involved in transfer of goods from producer to consumer or in the exchange of services.
Deep grooves or clefts in the surface of teeth equivalent to class 1 cavities in Black's classification of dental caries.
The effort of two or more parties to secure the business of a third party by offering, usually under fair or equitable rules of business practice, the most favorable terms.
Expendable and nonexpendable equipment, supplies, apparatus, and instruments that are used in diagnostic, surgical, therapeutic, scientific, and experimental procedures.
Process that is gone through in order for a device to receive approval by a government regulatory agency. This includes any required preclinical or clinical testing, review, submission, and evaluation of the applications and test results, and post-marketing surveillance. It is not restricted to FDA.
Freedom of equipment from actual or potential hazards.
Laws and regulations pertaining to devices used in medicine, proposed for enactment, or enacted by a legislative body.
A group of islands in the southwest Pacific. Its capital is Wellington. It was discovered by the Dutch explorer Abel Tasman in 1642 and circumnavigated by Cook in 1769. Colonized in 1840 by the New Zealand Company, it became a British crown colony in 1840 until 1907 when colonial status was terminated. New Zealand is a partly anglicized form of the original Dutch name Nieuw Zeeland, new sea land, possibly with reference to the Dutch province of Zeeland. (From Webster's New Geographical Dictionary, 1988, p842 & Room, Brewer's Dictionary of Names, 1992, p378)
An agency of the PUBLIC HEALTH SERVICE concerned with the overall planning, promoting, and administering of programs pertaining to maintaining standards of quality of foods, drugs, therapeutic devices, etc.
Removal of a MEDICAL DEVICE from the market due to a problem occurring in the manufacture or distribution of the product.
A worm-like blind tube extension from the CECUM.
Nonexpendable items used in examination.
Organic compounds which contain tin in the molecule. Used widely in industry and agriculture.
A peroxide derivative that has been used topically for BURNS and as a dermatologic agent in the treatment of ACNE and POISON IVY DERMATITIS. It is used also as a bleach in the food industry.
Polymers of organic acids and alcohols, with ester linkages--usually polyethylene terephthalate; can be cured into hard plastic, films or tapes, or fibers which can be woven into fabrics, meshes or velours.
An ethylene compound with two hydroxy groups (-OH) located on adjacent carbons. They are viscous and colorless liquids. Some are used as anesthetics or hypnotics. However, the class is best known for their use as a coolant or antifreeze.
Inorganic compounds that contain zinc as an integral part of the molecule.
Eight-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives.
A vasodilator with general properties similar to NITROGLYCERIN but with a more prolonged duration of action. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1025)
The residual portion of BLOOD that is left after removal of BLOOD CELLS by CENTRIFUGATION without prior BLOOD COAGULATION.
Exclusive legal rights or privileges applied to inventions, plants, etc.
All blood proteins except albumin ( = SERUM ALBUMIN, which is not a globulin) and FIBRINOGEN (which is not in the serum). The serum globulins are subdivided into ALPHA-GLOBULINS; BETA-GLOBULINS; and GAMMA-GLOBULINS on the basis of their electrophoretic mobilities. (From Dorland, 28th ed)
The process by which blood or its components are kept viable outside of the organism from which they are derived (i.e., kept from decay by means of a chemical agent, cooling, or a fluid substitute that mimics the natural state within the organism).
The transfer of blood components such as erythrocytes, leukocytes, platelets, and plasma from a donor to a recipient or back to the donor. This process differs from the procedures undertaken in PLASMAPHERESIS and types of CYTAPHERESIS; (PLATELETPHERESIS and LEUKAPHERESIS) where, following the removal of plasma or the specific cell components, the remainder is transfused back to the donor.
Containers, packaging, and packaging materials for drugs and BIOLOGICAL PRODUCTS. These include those in ampule, capsule, tablet, solution or other forms. Packaging includes immediate-containers, secondary-containers, and cartons. In the United States, such packaging is controlled under the Federal Food, Drug, and Cosmetic Act which also stipulates requirements for tamper-resistance and child-resistance. Similar laws govern use elsewhere. (From Code of Federal Regulations, 21 CFR 1 Section 210, 1993) DRUG LABELING is also available.
A genus of mosquitoes (CULICIDAE) frequently found in tropical and subtropical regions. YELLOW FEVER and DENGUE are two of the diseases that can be transmitted by species of this genus.
Substances that cause the adherence of two surfaces. They include glues (properly collagen-derived adhesives), mucilages, sticky pastes, gums, resins, or latex.
An adhesion procedure for orthodontic attachments, such as plastic DENTAL CROWNS. This process usually includes the application of an adhesive material (DENTAL CEMENTS) and letting it harden in-place by light or chemical curing.
Dental cements composed either of polymethyl methacrylate or dimethacrylate, produced by mixing an acrylic monomer liquid with acrylic polymers and mineral fillers. The cement is insoluble in water and is thus resistant to fluids in the mouth, but is also irritating to the dental pulp. It is used chiefly as a luting agent for fabricated and temporary restorations. (Jablonski's Dictionary of Dentistry, 1992, p159)

Histological changes in the rat common carotid artery induced by aneurysmal wrapping and coating materials. (1/247)

Histological changes in and around the arterial walls of rats were investigated following topical application of aneurysmal wrapping and coating materials, including a fibrin glue, a cyanoacrylate glue (Biobond), and cotton fibers (Bemsheet). Bilateral common carotid arteries were exposed using sterile techniques, and one of the test materials was applied to the right artery. The left artery was used as the control. Changes in arterial histology were evaluated at 2 weeks, 1 month, 2 months, and 3 months after surgery. The fibrin glue was surrounded by intense inflammation at 2 weeks after surgery. Both the fibrin glue and inflammation had disappeared at 2 months, but the glue had induced mild inflammation in the adventitia. Biobond caused chronic inflammation, necrosis of the media, and thickening of the arterial wall due to fibrosis in both the media and adventitia. Bemsheet produced chronic inflammation, progressive fibrosis, and granuloma. Connective tissue increased in the adventitia, but no major changes were observed in the media. The Bemsheet fibers remained unchanged, and adhered to the arterial wall. Although arterial stenoses were not observed in the present study, the results suggest that cyanoacrylate glue can cause the arterial occlusive lesions observed following aneurysm surgery.  (+info)

Postoperative magnetic resonance imaging after acoustic neuroma surgery: influence of packing materials in the drilled internal auditory canal on assessment of residual tumor. (2/247)

Serial magnetic resonance (MR) images taken after acoustic neuroma surgery were analyzed to evaluate the pattern and timing of postoperative contrast enhancement in 22 patients who underwent acoustic neuroma removal via the suboccipital transmeatal approach. The opened internal auditory canal (IAC) was covered with a muscle piece in nine patients and with fibrin glue in 13. A total of 56 MR imaging examinations were obtained between days 1 and 930 after surgery. MR imaging showed linear enhancement at the IAC within the first 2 days after surgery, and revealed nodular enhancement on day 3 or later in patients with a muscle piece. MR imaging tended to show linear enhancement at the IAC, irrespective of the timing of the examination in the patients with fibrin glue. Postoperative MR imaging on day 3 or later showed the incidence of nodular enhancement in patients with muscle was significantly higher than in patients with fibrin glue. The results illustrate the difficulty in differentiating nodular enhancement on a muscle piece from tumor by a single postoperative MR imaging study. Therefore, fibrin glue is generally advocated as a packing material of the IAC because it rarely shows masslike enhancement on postoperative MR imaging. When a muscle piece is used in patients at high risk for postoperative cerebrospinal fluid leaks, MR imaging should be obtained within the first 2 days after surgery, since benign enhancement of muscle will not occur and obscure the precise extent of tumor resection.  (+info)

Modulation of vascular cell growth kinetics by local cytokine delivery from fibrin glue suspensions. (3/247)

PURPOSE: Fibrin glue (FG) has been used as a delivery system for bioactive agents on grafts and angioplasty sites. Reports from two different institutions suggest that heparin concentrations of 500 U/mL in FG inhibit smooth muscle cell (SMC) proliferation, but do not effect endothelial cell (EC) proliferation. The purposes of this study were to (1) quantify the diffusive release of fibroblast growth factor-1 (FGF-1) and heparin from FG; (2) determine the effect of heparin and FGF-1 on SMC proliferation when the cells are immediately plated on the FG; and (3) by means of the diffusive release data, design a new in vitro model that may differentiate the effect of FG-incorporated FGF-1 and heparin, rather than the released, solubilized components of these two factors, on SMC and EC proliferation. METHODS: 125I-FGF-1 or 3H-heparin release from FG into the overlying media was measured serially in a 96-hour period, either with or without cells. SMCs were immediately plated on FG containing various concentrations of FGF-1 and heparin. SMCs or ECs were plated on identical groups of FG containing FGF-1 and heparin 24 hours after the FG was made to exclude the effect on cell growth of the initial release of FGF-1 into the media. RESULTS: In the first 24 hours, 70% +/- 1% of the FGF-1 and 59% +/- 2% of the heparin in the FG was released into the overlying media, with minimal release occurring thereafter. The cell type or absence of cells did not affect release, but there was five times more FGF-1 and four times more heparin in the media at 72 hours for the immediate plating versus the delayed plating because of a diffusive release primarily in the first 24 hours. A heparin concentration of 500 U/mL inhibited SMC proliferation, as compared with 5 U/mL heparin, only when immediate plating of SMCs was used. Comparing immediate versus delayed SMC plating, at equivalent FGF-1 and heparin doses, immediate plating induced greater proliferation than delayed plating; this was likely caused by the higher soluble FGF-1 concentration. Heparin doses as high as 500 U/mL had little effect on SMC proliferation. In contrast, ECs died with delayed plating on FG containing 500 U/mL heparin, and their growth was inhibited at 50 U/mL heparin, as compared with 5 U/mL heparin. CONCLUSION: The differences in SMC proliferation when comparing immediate versus delayed plating are likely caused by diffusive release of heparin and FGF-1 into the media. Our ongoing work uses an optimized in vitro FG system that minimizes the effects of soluble factors. This is an important distinction, because the cytokines that are released in vivo will be removed by blood flow and, thus, may not exert an effect unless they are contained within the FG.  (+info)

Mesh-and-glue technique to prevent leakage of cerebrospinal fluid after implantation of expanded polytetrafluoroethylene dura substitute--technical note. (4/247)

Expanded polytetrafluoroethylene (ePTFE) can be used as a dura substitute but is associated with leakage of cerebrospinal fluid (CSF) through the suture line. Fibrin glue alone may not prevent this problem. This new method for sealing the suture line in ePTFE membrane uses an absorbable polyglycoic acid mesh soaked with fibrinogen fluid placed on the suture line. Thrombin fluid is then slowly applied to the wet mesh, forming a large fibrin membrane reinforced by the mesh over the suture line. Only one of 33 patients in whom this technique was used had CSF leakage, whereas 12 of 59 patients in whom a dural defect was closed with ePTFE alone showed postoperative subcutaneous CSF collection (p < 0.05). Our clinical experiences clearly show the efficacy of the mesh-and-glue technique to prevent CSF leakage after artificial dural substitution. Mesh and glue can provide an adequate repair for small dural defect. The mesh-and-glue technique may also be used for arachnoid sealing in spinal surgery.  (+info)

Hemostatic efficacy of fibrin sealant (human) on expanded poly-tetrafluoroethylene carotid patch angioplasty: a randomized clinical trial. (5/247)

PURPOSE: The efficacy of solvent-detergent-treated fibrin sealant (human [FSH]) for controlling anastomotic bleeding from expanded polytetrafluoroethylene (ePTFE) patch angioplasty during carotid endarterectomy was evaluated, and FSH was compared with thrombin-soaked gelatin sponge (Gelfoam; TSG). METHODS: The study was of a randomized, open-label, single-site, single-treatment, parallel design that took place in a referral center with hospitalized patients. Forty-seven adult patients (33 men, 14 women) underwent elective carotid endarterectomy. Patients were randomized to receive either FSH (N = 24) or TSG (N = 23). FSH was obtained as an investigational new drug. FSH was applied as a liquid by means of a dual-syringe technique. Heparin anticoagulation, patch thickness, and suture type were standardized. Two different needle sizes were used (CV-6, PT-13: N = 21 [FSH: N = 10, TSG: N = 11]; CV-6, PT-9: N = 26 [FSH: N = 14, TSG: N = 13]). The FSH or TSG was applied to the ePTFE patch, and then blood flow was restored through the carotid artery. Degree of anticoagulation was assessed by anti-factor Xa activity. The time from restoration of carotid blood flow until achieving hemostasis was recorded. The blood loss from patch suture hole bleeding was measured. Completion intraoperative duplex ultrasound scanning was performed in all cases. Heparin was reversed with protamine sulfate. The primary end point was successful hemostasis within 15 minutes of restoration of carotid blood flow. The secondary end points were the amount of blood loss caused by suture line bleeding and the time to achieve hemostasis. RESULTS: There was no difference in the number of patients with complete hemostasis at 15 minutes (TSG, 13 of 23; FSH, 12 of 24; P =.77). The measured blood loss was 99.0 +/- 119.9 (SD) mL for TSG, and 105.0 +/- 107.9 mL for FSH (P =.86). The time to hemostasis was the same for both groups (TSG, 16.5 +/- 16.5 minutes; FSH, 16.6 +/- 14.2 minutes; P =.97). Within both treatment groups, the use of larger needles (PT-13) was associated with greater blood loss (FSH, 169.7 +/- 124.2 mL; TSG, 172.7 +/- 151.5 mL) than was the use of smaller needles (PT-9; FSH, 58.8 +/- 66.3 mL; TSG, 34.1 +/- 25.6 mL; P =.036, P =.001, respectively). There were no postoperative strokes or bleeding complications in either group. No abnormalities were shown in either group by means of completion carotid duplex ultrasound scanning. CONCLUSION: FSH was equivalent, but not superior to, TSG in achieving hemostasis during carotid endarterectomy performed with ePTFE patch angioplasty. Adhesion properties of FSH to ePTFE are possibly different than those to native tissue and warrant additional investigation.  (+info)

Preoperative embolization of intracranial meningiomas with a fibrin glue preparation. (6/247)

BACKGROUND AND PURPOSE: Preoperative embolization expands the spectrum of meningioma that can be operated on safely. Our goal was to achieve the distalmost loading of the vascular bed and confluent tumor necrosis with a fibrin glue preparation in the preoperative embolization of meningiomas. METHODS: Between 1992 and 1997, 80 patients with a meningioma had diagnostic angiography with a standard transfemoral Seldinger technique, performed with a 6F guiding catheter and digital subtraction angiography. Preoperative embolization was carried out in the same session with an additional microcatheter system. Fibrin glue was the only component used. In all cases, CT was performed immediately after embolization; in nine patients, MR imaging was also performed. RESULTS: Angiography verified the elimination of tumor blush in all patients. The high-density areas seen on postembolization CT scans, caused by the fibrin glue dispersed in the embolized supply area, were found to be necrotic at surgery and were easily removed by suction. Two (2.5%) of the 80 patients had complications associated with embolization that resulted in neurologic deficits. CONCLUSION: The most effective preoperative embolization of tumors requires a distalmost loading of the vascular bed. Fibrin glue, which is easy to use and safe to handle, causes confluent tumor necrosis within the injected vascular territory.  (+info)

The S130K fibroblast growth factor-1 mutant induces heparin-independent proliferation and is resistant to thrombin degradation in fibrin glue. (7/247)

OBJECTIVE: Site-directed mutagenesis is an important technique that can alter cytokine function, thereby eliciting desired responses. S130K is a mutation of fibroblast growth factor-1 (FGF-1), with lysine replacing serine in the heparin-binding site. We measured molecular stability and mitogenic activity of FGF-1 and S130K, both in the media and when suspended in fibrin glue (FG), on smooth muscle cells (SMCs) and endothelial cells (ECs) to determine if the mutation altered the function and potential clinical applicability. METHODS: EC and SMC proliferation of soluble FGF-1 or S130K at 0, 0. 1, 1, 10, or 100 ng/mL with heparin at 0, 5, 50, or 500 units (U)/mL was measured on growth-arrested cells in serum-free media. EC and SMC proliferation assays with cells on FG containing either FGF-1 or S130K at 0, 1, 10, 100, or 1000 ng/mL in combination with heparin at 0, 5, 50 or 500 U/mL were also performed during the exponential growth phase. Molecular degradation by thrombin was measured by sodium dodecylsulfate-polyacrylamide gel electrophoresis. RESULTS: S130K induces greater EC and SMC proliferation in the absence of heparin than FGF-1 does (P <.0001 for both the 10 and 100 ng/mL doses). S130K is also significantly more potent than FGF-1 in the presence of heparin. Heparin in the media enhances cytokine-induced SMC and EC proliferation at doses of 5 U/mL, but inhibits SMC proliferation at concentrations of 500 U/mL. For the FG data, unlike FGF-1, S130K induces EC and SMC proliferation in the absence of heparin. The addition of 5 U/mL of heparin enhances the proliferation induced by S130K. For ECs, as the heparin dose increases to 50 U/mL, proliferation decreases, as compared with the 5 U/mL concentration when either FGF-1 or S130K in the FG was compared at concentrations of 10, 100, and 1000 ng/mL (P <.01). S130K is more potent in FG than is FGF-1 both with and without heparin and exhibits maximal EC and SMC proliferation at 10 ng/mL, whereas FGF-1 activity is maximal at 100 ng/mL. Gel electrophoresis demonstrated that S130K was relatively more resistant to thrombin degradation than FGF-1. CONCLUSIONS: Site-directed mutagenesis changed the potency and the heparin dependency on cellular proliferation of FGF-1 in vitro. These techniques should allow the delivery of mutant growth factors to areas of vascular intervention to induce specific, desired responses. We believe that these studies will enhance our knowledge of the function of various regions of the FGF-1 molecule, allowing us to more precisely design increasingly more useful FGF-1 mutants.  (+info)

Oozing type cardiac rupture repaired with percutaneous injection of fibrin-glue into the pericardial space: case report. (8/247)

Two patients, a 56-year-old man and an 81-year-old woman who were admitted to hospital because of anteroseptal acute myocardial infarction, were initially treated successfully with direct percutaneous transluminal coronary angioplasty. However, both patients later developed sudden cardiogenic shock due to cardiac tamponade caused by left ventricular free wall rupture (LVFWR). Prompt, life-saving pericardiocentesis was performed, then fibrin-glue was percutaneously injected into the pericardial space. After the procedure, there was no detectable pericardial effusion on echocardiography and the hemodynamic state became stable. The surgical treatment was the standard procedure for LVFWR, but percutaneous fibrin-glue therapy can also be considered for oozing type LVFWR.  (+info)

Purpose: : The purpose of this study is to compare the safety and efficacy of fibrin tissue adhesive to suture conjunctival fornix-based flap wound closure in trabeculectomy surgery. Methods: : This is a comparative interventional review of the most recent 38 patients that underwent combined cataract extraction surgery and trabeculectomy surgery with 6 months of follow-up. 18 eyes of 18 patients with fibrin tissue adhesive conjunctival flap closure are compared to 20 eyes of 20 patients who underwent the same procedure except with suture conjunctival flap closure. Patient demographics, surgical times, pre- and post-operative intraocular pressure (IOP), glaucoma medications, intraoperative and postoperative complications such as wound leaks and bleb dysesthesia were recorded and compared. Results: : There were no significant differences in the age, postoperative IOP and number of medications pre- and post-operatively (P , 0.05). In the suture group, the IOP decreased from 18.7 ± 0.87 (mean ...
Fibrin-based tissue adhesives can be created from autologous sources or pooled blood. They are typically used for hemostasis and can seal tissues. Although they do not have adequate tensile strength to close skin, fibrin tissue adhesives can be used to fixate skin grafts or seal cerebrospinal fluid leaks. Commercial preparations such as Tisseel (Baxter) and Hemaseel (Haemacure) are FDA-approved fibrin tissue adhesives made from pooled blood sources. These fibrin tissue adhesives are relatively strong and can be used to fixate tissues. Autologous forms of fibrin tissue adhesives can be made from patients plasma. The concentration ...
TY - JOUR. T1 - A comparison between endoscopic injection of bleeding esophageal varices using ethanolamine oleate and fibrin glue sealant in patients with bilharzial liver fibrosis [1]. AU - Naga, M. I.. AU - Goubran, H. A.. AU - Said, M.. AU - Burnouf-Radosevich, M.. AU - Burnouf, T.. AU - Huart, J. J.. PY - 1999. Y1 - 1999. UR - http://www.scopus.com/inward/record.url?scp=0032988486&partnerID=8YFLogxK. UR - http://www.scopus.com/inward/citedby.url?scp=0032988486&partnerID=8YFLogxK. M3 - Letter. C2 - 10433054. AN - SCOPUS:0032988486. VL - 31. SP - 405. JO - Endoscopy. JF - Endoscopy. SN - 0013-726X. IS - 5. ER - ...
Abstract Fibrin glue has been widely used in a variety of surgical procedures to promote haemostasis and tissue bonding. It can also be used as a cell carrier for stem cells on tendons. However, the data about the effect of fibrin glue on flexor tendon healing is very limited. The present study examined the role of fibrin glue TISSEEL® in a rabbit model of flexor tendon injury. The rabbits were killed 3 or 8 weeks after the operation. The range-of-motion of the fingers and biomechanical properties of tendons were measured and compared between the control group and TISSEEL-treated group. The findings have shown that the range-of-motion in the TISSEEL-treated group was significantly different from that of the control group at 3 weeks after the operation. However, there is no significant difference in range-of-motion at 8 weeks after the operation. Moreover, there is no significant difference in biomechanical properties between the control group and TISSEEL-treated group. The results indicate that TISSEEL
Purpose To investigate pain and other complications following inguinal hernioplasty performed by the Lichtenstein technique with mesh fixation by fibrin glue or sutures. Methods Five hundred and twenty patients were enrolled in this 12-month observational multicenter study and received either sutures or fibrin glue (Tissucol/Tisseel) based on the preference of the surgeon. Pain, numbness, discomfort, recurrence, and other complications were assessed postoperatively and at 1, 3, 6, and 12 months. Pain intensity was assessed by a visual analog scale VAS; 0 [no pain] to 10 [worst pain]). Results One hundred and seventy-one patients received sutures and 349 received fibrin glue. During the early postoperative phase, 87.4% of patients in the fibrin glue group and 76.6% of patients in the sutures group were complication-free (P = 0.001). Patients who received fibrin glue were also less likely to experience hematoma/ecchymosis than those in the suture group (both P = 0.001). The mean pain score was ...
PURPOSE To study the use of fibrin sealant as a drug delivery system for the sustained transscleral delivery of dexamethasone and methotrexate. METHODS Scleral sections excised from moist-chamber-stored human globes were mounted in a perfusion chamber. Dexamethasone-fluorescein or methotrexate-fluorescein in either fibrin sealant or balanced salt solution (BSS) was applied to the episcleral surface. BSS was perfused to the choroidal side, fluorescence was measured in perfusate fractions, and an apparent scleral permeability P(A) was calculated for each solute-vehicle combination. RESULTS P(A) for both compounds was significantly lower with fibrin sealant delivery compared to delivery in BSS (p | 0.001). However, the fibrin sealant vehicle provided a more sustained release of both drugs through 24 hr. CONCLUSIONS Incorporating dexamethasone and methotrexate into a fibrin sealant provided a more gradual drug delivery and a more uniform delivery compared to dissolving these drugs in BSS. Fibrin
TY - JOUR. T1 - Fibrin sealant treatment of splenic injury during open and laparoscopic left radical nephrectomy. AU - Canby-Hagino, Edith D.. AU - Morey, Allen F.. AU - Jatoi, Ismail. AU - Perahia, Barak. AU - Bishoff, Jay T.. PY - 2000. Y1 - 2000. N2 - Purpose: We describe the use of fibrin sealant for rapid and definitive hemostasis of splenic injuries incurred during open and laparoscopic left nephrectomy. Materials and Methods: In 2 patients undergoing left nephrectomy for a suspicious renal mass splenic laceration occurred during mobilization of the colonic splenic flexure at open nephrectomy and laparoscopic upper pole dissection, respectively. Fibrin sealant was applied topically in each case. Results: In each patient fibrin sealant achieved immediate hemostasis and each recovered without further splenic bleeding. Conclusions: The topical application of fibrin sealant safely, rapidly and reliably achieves definitive hemostasis of splenic injuries. It is simple to use in the open and ...
To investigate the application of endoscopic injection of human fibrin sealant in treatment of patients with intrathoracic anastomotic leakage after esophagectomy. A total of 179 patients who underwent intrathoracic anastomosis after esophageal cancer surgery in our department From December 2012 to May 2015 were retrospectively analyzed. The clinical data and treatment of 7 patients with postoperative intrathoracic anastomotic leakage were analyzed and discussed. On Day 28 after operation, the 7 patients were given endoscopic injection of human fibrin sealant to seal the anastomotic leakage, and the changes in drainage volume, body temperature, CRP, white blood cell count and other indicators were compared before and after endoscopic intervention. After endoscopic injection of human fibrin sealant in all 7 patients with intrathoracic anastomotic leakage, the volume of para-anastomotic drainage, CRP, and WBC count were improved compared with those before treatment. Relevant data were analyzed, and the
摘要: Objective:The use of fibrin adhesives has a broad background in nerve repair.Currently the suboptimal physical properties of singledonor fibrin adhesives have restricted their usage.The present experiment studies the performance and physical characteristics of a modified fibrin glue prepared from single-donor human plasma in the repair of posterior tibial nerve of rat.Methods:Forty Wistar rats were divided into 5 groups; in the control group,tibial nerve was completely transected and no treatment was done,while in the four experimental groups the nerve stumps were reconnected by one suture,three sutures,one suture with fibrin glue and fibrin glue alone respectively.During 8 weeks of follow-up,Tibial Function Index was measured weekly and adhesive strength,inflammation and scar formation were assessed at the end of the study.Results:Nerve stumps dehiscence rate and adhesive strength were similar in all experimental groups and significantly differed from control group (P<0.05).By the ...
Human Fibrin Sealant The research study focuses on Global Human Fibrin Sealant Market with major leading industry players with information such as company profiles, product picture and specification, capacity, production, price, cost, revenue and contact information. Upstream raw materials, equipment and downstream consumers analysis is also carried out. Learn details of the major leading industry…
Hypersensitivity Reactions: Hypersensitivity reactions including allergic/and anaphylactoid reactions can occur with the use of TISSEEL. Cases have been reported in post marketing experience with Baxters fibrin sealant.In specific cases, these reactions have progressed to severe anaphylaxis. Such reactions may especially be seen if TISSEEL is applied repeatedly over time or in the same setting, or if systemic aprotinin has been administered previously. Even if the first treatment was well tolerated, this may not exclude the occurrence of an allergic reaction after a subsequent administration of TISSEEL or systemic aprotinin. Observed symptoms of allergic anaphylactic reactions to TISSEEL have included: bradycardia, tachycardia, hypotension, flushing, bronchospasm, wheezing, dyspnea, nausea, urticaria, angioedema, pruritus, erythema and paresthesia. Such reactions can also occur in patients receiving TISSEEL for the first time ...
Brachial plexus lesion results in loss of motor and sensory function, being more harmful in the neonate. Therefore, this study evaluated neuroprotection and regeneration after neonatal peripheral nerve coaptation with fibrin sealant. Thus, P2 neonatal Lewis rats were divided into three groups: AX: sciatic nerve axotomy (SNA) without treatment; AX+FS: SNA followed by end-to-end coaptation with fibrin sealant derived from snake venom; AX+CFS: SNA followed by end-to-end coaptation with commercial fibrin sealant. Results were analyzed 4, 8, and 12 weeks after lesion. Astrogliosis, microglial reaction, and synapse preservation were evaluated by immunohistochemistry. Neuronal survival, axonal regeneration, and ultrastructural changes at ventral spinal cord were also investigated. Sensory-motor recovery was behaviorally studied. Coaptation preserved synaptic covering on lesioned motoneurons and led to neuronal survival. Reactive gliosis and microglial reaction decreased in the same groups (AX+FS, AX+CFS) at 4
TY - JOUR. T1 - Analysing uncertainty around costs of innovative medical technologies: the case of fibrin sealant (QUIXIL) for total knee replacement.. AU - Steuten, Lotte Maria Gertruda. AU - Vallejo-Torres, Laura. AU - Bastide, Philippe. AU - Buxton, Martin J.. PY - 2009. Y1 - 2009. N2 - This paper presents a relatively simple cost model comparing the costs of using a commercial fibrin sealant (QUIXIL®) in addition to conventional haemostatic treatment vs. conventional treatment alone in total knee replacement (TKR) surgery, and demonstrates and discusses how one- and two-way sensitivity analyses can inform decisions regarding an innovative medical technology, for which there is limited evidence on economic parameters. The model synthesises data from various sources and assesses the proportion of individuals likely to need blood transfusion, the resource use after TKR and transfusion-related adverse events. Whether using fibrin sealant is cost saving strongly depends on the amount used, the ...
Subjects in the FS group will be operated by Lichtenstein technique, with mesh fixation by fibrin sealant. Subjects in control group will be operated with conventional Lichtenstein technique (mesh fixation by sutures).. Hernia repair will be performed according to standardized Lichtenstein technique, a technique for tension free hernioplasty. A Polypropylene, heavyweight, macroporous mesh will be used (8x15 cm) tailored to individual patients requirement. The different ways of mesh fixation will be randomly assigned within 24 hours before the operation. In the FS group, the two tails of the mesh will be fixed together in overlapping their edges and by surrounding the cord. The edges will be joined up to by 1 suture. No other sutures will be used. First the mesh will be put correctly in place. A small spot (0.5ml) of FS will be applied on the pubis under the mesh without spray then the remaining part (3,5ml) over the mesh on the entire surface in a thin uniform layer by spray. 2 ml ...
TY - JOUR. T1 - Maximization of the sealing effect of fibrin glue in aortic surgery. AU - Naganuma, Masaaki. AU - Akiyama, Masatoshi. AU - Takaya, Hiroki. AU - Sakuma, Kei. AU - Kumagai, Kiichiro. AU - Kawamoto, Shunsuke. AU - Adachi, Osamu. AU - Saiki, Yoshikatsu. PY - 2020/1/1. Y1 - 2020/1/1. N2 - Objectives: Fibrin glue is used to reinforce anastomosis in aortic surgery. There has not yet been a consensus on how it should be applied optimally. This study aimed to define the optimal condition of applying fibrin glue. Methods: In experiment 1, we determined the optimal condition for spraying fibrin glue using an expanded polytetrafluoroethylene graft within a needle hole. The length and area of the fibrin cap within the hole were measured. In experiment 2, methods for applying fibrinogen were assessed by comparing brushing and spraying. In experiment 3, swine aorta segments sutured with a Dacron graft were divided into the following three groups: nothing was applied; fibrinogen was sprayed and ...
In the United States, fibrin sealants have been used to achieve hemostasis for nearly two decades. Although their clinical utility was first demonstrated in cardiac surgery, their effectiveness and safety have since been demonstrated to extend to a wide array of procedures. Fibrin sealants typically contain two components-fibrinogen and thrombin-that are combined and delivered simultaneously to a target bleeding site in order to achieve hemostasis.
THESIS: H. O. Stolf submitted this thesis for his Doctor of Philosophy degree in Dermatology publicly examined at the Escola Paulista School of Medicine, UNIFESP, São Paulo, Brazil in 1998.. Advisor: Profa. Dra. Neuza Lima Dillon. ABSTRACT. Fibrin adhesive derived from snake venom mimics the last steps of the blood coagulation. Bubaline fibrinogen interacts with the thrombin-like fraction from snake venom, releasing a monomeric fibrin. This, in the presence of factor XIII and calcium, transforms into a polymeric substance with adhesive properties. This biological glue unites wound surfaces and assists in hemostasis. This study evaluates the adhesive and hemostatic properties of this new glue in skin surgery. It also compares the cosmetic results obtained with fibrin glue and 5-0 nylon. Twenty-one male and female Caucasian patients (mean age 64 years) with skin tumor participated in this study. After tumor removal, the excised areas were covered with skin removed from the right and left ...
Background: Excessive postoperative drainage following groin and axillary lymphadenectomy may be associated with a prolonged hospital stay and an increased complication rate. The use of fibrin sealant before wound closure may reduce postoperative wound drainage. Methods: Consecutive patients undergoing elective groin or axillary lymphadenectomy were randomized to standard wound closure or to having fibrin sealant sprayed on to the wound bed before closure. Postoperative wound drainage, duration of drainage and complications were recorded, as were locoregional recurrence, distant metastasis and mortality. Results: A total of 74 patients requiring 38 groin and 36 axillary dissections were randomized. The median postoperative wound drainage volume for the groin dissection cohort was 762 (range 25-3255) ml in the control group and 892 (265-2895) ml in the treatment group (P = 0·704). Drainage volumes in the axillary cohort were 590 (230-9605) and 565 (30-1835) ml in the control and treatment groups
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This study was investigated of the bone healing capacity by autologous fibrin glue in experimental bone defect dogs. The autologous fibrin glue manufactured just before the experiment was mixed with the concentrated fibrinogen from whole blood of the experimental dog and bovine thrombin. The experim...
Holevn Health chia sẻ bài viết : Thuốc Tisseel , công dụng liều dùng tác dụng phụ của Thuốc Tisseel, thuốc Thuốc Tisseel điều trị bệnh gì, công dụng và liều dùng của như thế nào ? Các tác dụng phụ thường gặp . Holevn Health mời bạn đọc tham khảo thông tin chi tiết bên dưới.
Fistula development after esophageal resection is considered as one of the most serious postoperative complications. The authors reported a case on clinical experiences in the postoperative diagnostic and successful therapeutic management of a tracheomediastinal fistula after esophageal resection, using endoscopic application of fibrin glue. The early approach of an anastomotic insufficiency after esophageal resection because of a squamous cell carcinoma (pT3pN0M0G2) below the tracheal bifurcation including transposition of a re-modelled gastric tube and end-to-side anastomosis 24 hours postoperatively in a 55-year old patient combined i) surgical re-intervention from the periesophageal site (reanastomosis, gastroplication, lavage, local and mediastinal drainage) and, later on, ii) extensive rinsing with consecutive endoscopic fibrin glue application into the tracheal mouth of the subsequently developed tracheomediastinal fistula as a consequence of the inflammatory changes within the ...
Fibrin sealant applicator systems are provided for dispensing a first and a second protein solution to form a biological adhesive which overcome the disadvantages of the prior art. The fibril sealant applicator system according to the present disclosure includes two piston-type sub-assemblies coupled to two vials storing a fibrinogen and a thrombin via a coupling unit. The piston-type sub-assemblies store sterilized water within reservoirs which are in fluid communication with the vials via the coupling unit. The water is forced into the vials to form a fibrinogen and a thrombin solution. The solutions are then drawn into the reservoirs and a Y-coupler is attached to the distal end of the piston-type sub-assemblies. The Y-coupler provides fluid communication between the reservoirs and a nozzle body for dispensing the solutions when distal pressure is created within the reservoirs to force the solutions towards the nozzle body.
Fibrin sealant applicator systems are provided for dispensing a first and a second protein solution to form a biological adhesive which overcome the disadvantages of the prior art. The fibril sealant applicator system according to the present disclosure includes two piston-type sub-assemblies coupled to two vials storing a fibrinogen and a thrombin via a coupling unit. The piston-type sub-assemblies store sterilized water within reservoirs which are in fluid communication with the vials via the coupling unit. The water is forced into the vials to form a fibrinogen and a thrombin solution. The solutions are then drawn into the reservoirs and a Y-coupler is attached to the distal end of the piston-type sub-assemblies. The Y-coupler provides fluid communication between the reservoirs and a nozzle body for dispensing the solutions when distal pressure is created within the reservoirs to force the solutions towards the nozzle body.
Somerville, NJ. ETHICON, INC. announced today that the U.S. Food and Drug Administration has granted an expanded indication for EVICEL Fibrin Sealant (Human). The product is the first fibrin seala...
Ethicon Biosurgery announced that the FDA has approved Evarrest Fibrin Sealant Patch, a topical product indicated for use with manual compression as an adjunct to hemostasis for soft tissue bleeding.
GASPAROTTO, VINICIUS P. O.... A new fibrin sealant as a three-dimensional scaffold candidate for mesenchymal stem cells. STEM CELL RESEARCH & THERAPY 5 n. p. JUN 10 2014. Journal article.
The objective of this study is to evaluate the safety and efficacy of EVICEL Fibrin Sealant (Human) for use as an adjunct to sutured dural repair in cranial
Guidance for Industry: Efficacy Studies to Support Marketing of Fibrin Sealant Products Manufactured for Commercial Use, Blood, CBER, Biologics
Global Fibrin Sealant Market - Premium Insight, Competitive News Feed Analysis, Company Usability Profiles, Market Sizing & Forecasts to 2025
A method to produce platelet-rich plasma and platelet concentrate using a double centrifuge technique in combination with the fibrin adhesive Tisseel is described. This technique constitutes the basic mixture for augmenting and improving an inadequate bone site. Also described is a procedure by which autologous bone or bone substitute is added to this mixture to increase the volume of grafting material. Platelet concentrates cause growth factors to be delivered to graft sites in an intense form, while Tisseel serves as a standardized, pharmaceutically manufactured fibrin adhesive ...
Recently, we have described a simple protocol to obtain an enriched culture of adult stem cells organized in neurospheres from two post-natal tissues: skin and adipose tissue. Due to their possible application in neuronal tissue regeneration, here we tested two kinds of scaffold well known in tissue engineering application: hyaluronan based membranes and fibrin-glue meshes. Neurospheres from skin and adipose tissue were seeded onto two scaffold types: hyaluronan based membrane and fibrin-glue meshes. Neurospheres were then induced to acquire a glial and neuronal-like phenotype. Gene expression, morphological feature and chromosomal imbalance (kariotype) were analyzed and compared. Adipose and skin derived neurospheres are able to grow well and to differentiate into glial/neuron cells without any chromosomal imbalance in both scaffolds. Adult cells are able to express typical cell surface markers such as S100; GFAP; nestin; βIII tubulin; CNPase. In summary, we have demonstrated that neurospheres
GHEA=Sum of 1-3 ratings. Excellent: 7-9 (no category ,2) Good: 5-7 (no category ,1) Fair: 3-4 (no category ,1) None 0-2 (≥ category 0). a. Intra operative hemostatic efficacy (Excellent=3: Good=2: Fair=1: None =0). b. Hemostatic efficacy postoperative Day 1 (Excellent=3: Good=2: Fair=1: None =0). c. Overall perioperative hemostatic efficacy at discharge or within 24 to 72 hours after last perioperative treatment dose of BAX 802 (whichever is earlier) (Excellent=3: Good=2: Fair=1: None =0 ...
Objective: The effects of fibrin glue (FG) and suture were investigated and compared with experimental induction in an endometriosis model. Material and Methods: A randomized, controlled, and double-blind study was performed ...
Fibrin glue market is a derivative of human blood products andanimaland it is mostly withdrawn from collective plasma and comprises of different quantities of purified and virally inactivated human proteins.
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Ethicon is devoted to shaping the future of surgery by advancing innovation, addressing the most pressing healthcare issues and improving lives every day.
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Vitruvians first product, MyoSeal, promotes wound repair via biocompatible microparticles plus a fibrin tissue sealant that has been shown to prevent incisional hernias through enhanced wound healing. The team believed that surgeons would embrace the product and pay thousands to use it. In week 2 of the class 14 of their potential customers (surgeons) told the team otherwise.. Watch this 90-second clip and find out how the Lean LaunchPad class saved them years.. Lessons Learned. ...
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If youve ever accidentally put super glue on your fingers, then you know how hard it can be to remove. Luckily its easier than you think!
FIBRINOGEN HUMAN AND THROMBIN HUMAN, 1 INDICATIONS AND USAGE RAPLIXA is a fibrin sealant indicated as an adjunct to hemostasis for mild to moderate bleeding in adults undergoing surgery when control of bleeding by standard surgical techn
PRODUCTS THE VIVOSTAT® SYSTEM SEE PRODUCT APPLICATION DEVICES SEE PRODUCT Vivostat® FIBRIN SEALANT SEE PRODUCT Vivostat PRF® SEE PRODUCT To the products
How to go about it:. 1. Prepare the tiles you will use (be it the broken plates, cut-up pieces of paper, etc.). It would be best if your tile pieces were flat and of the same thickness. This ensures that your final design will be even and have a flat surface.. 2. Sketch out your pattern on your base. If you are using an old table top, you may need to prep this This will help guide you in placing the tiles.. 3. Glue on the tiles on the appropriate spots of your design. Make sure you leave a little space in between each tile for the grout. This is what will make your design stand out.. 4. Prepare the grout by following instructions in the package. Using the squeegee, spread over the entire design making sure to fill up the spaces between the tiles. Scrape of the excess and wipe the design down with a cloth or towel. Be careful when doing this as the tiles may move since the grout and glue may not have set yet.. 5. Leave to dry for several hours before wiping down with a damp sponge to remove ...
Actually its a two-drop peyote. I used Miyuki beads for the first time and I think they are much more consistent in shape and size than Toho. This is the cuff that accidentally got damaged a few posts ago :) It all happened because, for some reason the lining, which fitted the flat base perfectly, did not fit it in its final shape. Im sure it is consistent with some laws of physics, however seems totally illogical to me! I cut and weave in some additional rows. Im lucky because I did not glue the beads to my lining, as I originally intended following some internet tutorial. I just could not bring myself to apply GLUE on my beautiful beaded fabric, and used needle and thread instead! ...
Introduction: Treatment of choice for pleomorphic adenoma of the hard palate is wide local resection of the tumor including the overlying mucosa and underlying periosteum. Most conventional methods for covering the resulting palatal wound are prosthetic devices. In this case, we examined the validity of grafting a polyglycolic acid sheet and fibrin glue over a mucosal defect of the palate with a bony surface, as a substitute for a surgical splint. Case Report: A 39-year-old male presented with a large, solid mass located on the right hard palate. Fine-needle aspiration cytology suggested pleomorphic adenoma. The patient underwent wide local resection of the lesion, and the mucosal defect was immediately covered with polyglycolic acid sheets, that were fixed with a fibrin glue spray. These sheets were tightly placed and remained in the wound, which led to complete epithelialization of the wound surface. Conclusion: Grafting the polyglycolic acid sheet with fibrin glue fixation is a useful substitute for
TY - JOUR. T1 - Tissue adhesives and fibrin glues. T2 - NOVEMBER 2003. AU - Petersen, Bret Thomas. AU - Barkun, Alan. AU - Carpenter, Steven. AU - Chotiprasidhi, Poonputt. AU - Chuttani, Ram. AU - Silverman, William. AU - Hussain, Nadem. AU - Liu, Julia. AU - Taitelbaum, Greta. AU - Ginsberg, Gregory G.. PY - 2004/9. Y1 - 2004/9. N2 - Synthetic and biologic tissue glues have been used for control of bleeding and closure of fistulas and anastomotic leaks. GI endoscopic applications of cyanoacrylate and fibrin glues are considered off-label uses. Embolization and death have been reported with cyanoacrylate injection for hemostasis. Embolization also can occur from intravascular injection of thrombin or fibrin glue. Fibrin glue/thrombin can induce antibody formation with subsequent coagulopathy; however, this is a rare event with use of human-source blood products. There are insufficient data to support routine endoscopic use of the available preparations of cyanoacrylate, fibrin glue, and ...
Introduction: One of the most common complications following total laryngectomy is pharyngocutaneous fistula (PCF). Various methods have been proposed to treat this disorder in recent studies, including a range of simple and conservative treatments to more aggressive therapies, such as various surgical procedures. One of the most innovative and least developed methods is the use of plasma-rich compounds, such as fibrin glue. Case Report: The patient was a 55-year-old woman with a transglottic squamous cell carcinoma of the T3N0M0 stage and PCF development following total laryngectomy surgery with total thyroidectomy and bilateral elective cervical lymph node dissection level I-IV. In spite of conservative treatment, the fistula was not recovered after 3 weeks. It was decided to perform fibrin glue injection into the fistula tract via the endoscopic approach. One month after the fibrin glue injection, no evidence of contrast extravasation was observed on barium swallow test, and the fistula was
TY - JOUR. T1 - Fibrin sealant. T2 - Scientific rationale, production methods, properties, and current clinical use. AU - Radosevich, M.. AU - Goubran, H. A.. AU - Burnouf, T.. PY - 1997/4. Y1 - 1997/4. N2 - Fibrin sealant is a complex plasma-derived product which is increasingly used as a biodegradable tissue adhesive or sealant to stop or control bleeding or provide air and fluid tightness in many surgical situations. This review describes the historical development of current fibrin sealant preparations and the scientific rationale behind the alleged physiological benefits of its major plasma-derived components. A comparison in the extraction methods and viral reduction treatments applied to current commercial products and autologous preparations, and their respective advantages and limits, are discussed. Application devices used for surgical applications are described. A survey of the major clinical applications in various surgical areas is presented. Current issues in terms of viral safety, ...
TY - JOUR. T1 - Systematic review of the use of fibrin sealant to minimize perioperative allogeneic blood transfusion. AU - Carless, Paul A.. AU - Anthony, Danielle M.. AU - Henry, D. A.. PY - 2002. Y1 - 2002. N2 - Background: Fibrin sealants have become popular in improving perioperative haemostasis and reducing the need for allogeneic red cell transfusion. Methods: A systematic review of randomized controlled trials was conducted to examine the efficacy of fibrin sealants in reducing perioperative blood loss and allogeneic red blood cell transfusion. Studies were identified by computer searches of Medline, Embase, Current Contents, the Cochrane Library, manufacturer websites (to January 2001), and bibliographic searches of published articles. Trials were eligible for inclusion if they involved adult elective surgery and reported quantitative data on blood loss, the proportion of patients exposed to allogeneic red cell transfusion and/or the volume of blood transfused. Results: Twelve trials ...
This study evaluating fibrin sealant application in total knee arthroplasty (TKA) found significant differences in the decline in adjusted hemoglobin loss at 48 hours postoperatively in the treatment group (FS) relative to the control group (C) when the groups were segregated into early and late subgroups. The decline between the late C, 3.53 ± 0.22 g/dL, and the late FS, 3.01 ± 0.20 g/dL, was 0.52 g/dL (p = 0.04). The decline between the early C, 3.51 ± 0.21 g/dL, and the early FS, 3.25 ± 0.22 g/dL, was 0.26 g/dL (p = 0.34). This study demonstrates the importance of experience and education in successful application of tissue adhesives.. ...
Early on the first to third postoperative morning, fluid from abdominal discharge was collected for determination of amylase content. We evaluated the short-term outcomes and pancreatic fistula. ?Results?Mean age is 67 (range 36-81). 67 cases were men and 19 cases were women. According to the Japanese Classification of Gastric Carcinoma, 67 were stage?A, 10 were stage?B, 9 were stage?. The operation was undertaken with curative intent in all the patients.The standard D1 lymphadenectomy was performed in 74 cases, with D2 dissection in 12. Mean operating time was 205 (range 138-460) min. Mean blood loss was 90 (range 5-2450)ml. Blood. Reconstruction was by Billroth-?(n =36) or by Roux-en-Y (n =50). No patients had undergone splenectomy, Pancreatic fistula developed in 7 patients (LADG; 3, LATG: 4). No patients developed pancreatic fistula with fibrin glue and polyglycol acid felt. The patients without fibrin glue and polyglycol acid felt whose drainage fluid amylase levels on the first ...
During the wounding event, blood from capillaries at the damaged tissue site seeps out and reacts with tissue proteins and air to cause platelets and complement factors to trigger the cleavage of pro-thrombin into thrombin, which then changes fibrinogen into fibrin, the main insoluble component of a blood clot.. It was natural for practitioners, looking for effective hemostasis, to look at fibrin as a source of effective hemostatic activity. In the 19th century, physicians used fibrin powder to stop bleeding. During the period from 1940 to 1960, understanding of blood fractionation and the development of processes for preparing blood fractions meant that a pure form of fibrin could be prepared and manufactured in a stable format.. Fibrin sealants represent the most useful of surgical hemostats. These products can be used to clot blood but are also used to seal around suture lines for organ transplants, mastectomies, and various resection procedures, and to prevent leakage of fluids and gases. A ...
A Cost-benefit Analysis of Using Polyethylene Glycol Hydrogel Sealant versus Fibrin Glue as a Dural Sealant for Posterior Fossa Surgery in the United States ...
As for your second question, I do reglue tires a lot - for changing tread patterns, swapping out to road tires, or due to punctures - and I find it to be super easy with the Belgian Tape, once I manage to get the tire off, which is not easy. The tape usually comes off with the tire, although some hunks tend to stay on the rim. (This is as opposed to the Tufo or Jantex tapes, with which the tire always came off of the tape easily, leaving me to simply peel the tape off of the rim). I dig off the chunks of tape left on the rim with a screwdriver, scrub at the rim with a wire brush until there is only a thin layer of hardened glue left, dig off any remaining large glue lumps with a screwdriver, blow off the glue dust with compressed air, and scrub the rim with rubbing alcohol. Then, if its a road tire, I put two layers of glue on the rim and glue on a tire that has had two layers of glue on it as well. If its a cross tire, I glue new Belgian Tape on, followed by the tire. Works great.. To get ...
A pterygium is a wedge-shaped piece of abnormal tissue that grows out of the cornea. Whether or not surgical removal of a pterygium is recommended depends on its size and extent, as well as its tendency for recurrent inflammation. If a pterygium is small but becomes intermittently inflamed, the ophthalmologist may recommend the use of a nonsteroidal or a mild steroid eye drop when the inflammation develops. Removal is typically recommended if the pterygium grows far enough onto the cornea to impair vision, if it causes chronic inflammation and irritation, or if it interferes with contact lens wear.. Surgical removal of a pterygium is an outpatient procedure that takes less than an hour to perform. The risk of recurrence of the pterygium after surgery can be reduced with the use of a conjunctival graft taken from under the upper eyelid that is placed over the site where the pterygium was located. The graft may be secured with sutures or with human fibrin tissue glue (sutureless pterygium ...
Fingerprint Dive into the research topics of Invited commentary on effectiveness of fibrin glue in conjunction with collagen patches to reduce seroma formation after axillary lymphadenectomy for breast cancer. Together they form a unique fingerprint. ...
Short Scar Face-Lift with the Use of Fibrin Sealant. This article focuses on the short scar face-lift and the applicability of Tisseel fibrin sealant, or tissue glue, in expediting the healing process in a series of consecutive patients undergoing face-lift surgery by two surgeons (SR and AM).
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The fibrin, stem cell products, and growth factors combine to facilitate healing of the disc by repairing damaged disc tissue and stimulating growth of new tissue. This provides increased strength and stiffness of the disc wall and helps to stave off, slow down, or even reverse degeneration. The addition of stem cell products combined with your fibrin and PRP provides additional potent anti-inflammatory and regenerative benefits. Additionally, stem cell products injected into the nucleus help to regenerate the water loving, cushioning function of the disc. Ultimately, this treatment results in a healthier, less painful disc and improvement in your low back pain ...
Serum creatinine and BUN were determined photometrically on the 3rd and 10th postoperative days. Results General No animal died immediately after operation or within the period of observation. Three animals developed a unilateral wedge-shaped, ischemic renal infarction. Parenchymatous destruction to a maximum depth of 3-20 tubular lumina could be found in all other kidneys. In two cases a stone was found in the renal pelvis. Diffractometric X-ray analysis showed the stone composition to be calcium oxalate monohydrate. Turowski G, Schaadt M, Barthels M, Diehl V, Poliwada H (1980) Unterschiedlicher EinfluB von Fibrinogen und Faktor XIII auf das Wachstum von Primar- und Kulturfibroblasten. In: Schimpf K (ed) Fibrinogen, Fibrin und Fibrinkleber. FK Schattauer-Verlag, Stuttgart, pp 227-237 20. Knoche H, Schmitt G (1976) Autoradiographische Untersuchungen uber den EinfluB des Faktors XIII auf die Wundheilung im Tierexperiment. Arzneimittelforsch - Drug Res 26:547-551 21. Bruhn HD, Po hi J (1981) ...
I cleaned some of it immediately, but I missed some, and now I cant get it off my floor. I was able to scrape the bubbled part of the glue that had some dimension to it, but there is still a 12 thin film swath of the stuff on my floor, and no cleaning solvent or supply Ive tried have been able to dent the stuff. You can actually only see it when light hits it a certain way, but light tends to hit it a certain way a lot, and it looks bad. I believe the glue I used was something called Gorilla Glue that I picked up at Home Depot. My floors are not true hardwood, they appear to have some sort of coating that protects them from scuffs and scratches, but it seems as if whatever that coating is has fused to the superglue to make something I cant figure out how to remove ...
Evarrest is currently approved for use with manual compression as an adjunct to haemostasis for control of bleeding during adult liver surgery and soft tissue bleeding during open retroperitoneal, intra-abdominal, pelvic, and non-cardiac thoracic surgery when control of bleeding by standard surgical methods of haemostasis (eg., suture, ligature, cautery) is ineffective or impractical. If approved by the FDA, Evarrest could be used as an adjunct for general haemostasis.. Controlling bleeding in a highly complex surgical procedure, like aortic reconstruction, can be challenging, said Sina Moainie, cardiothoracic surgeon at St Vincent Heart Center of Indiana in Indianapolis, USA, and one of the studys investigators. Once again, Evarrest demonstrated positive results, even under the most challenging circumstances such as when applied to a prosthetic graft while on cardiopulmonary bypass and hypothermia.. The objective of this randomised multicentre Phase III clinical study was to evaluate the ...
Raplixa™ is a novel fibrin sealant containing a blend of human fibrinogen and thrombin in powder form. It is approved in adults to help control bleeding when standard surgical techniques have been insufficient. This article summarizes the product characteristics of Raplixa and provides a narrative review of its clinical use and tolerability. Unlike other available fibrin sealants, including liquid agents and lyophilized powders, the dry-powder, ready-to-use formulation of Raplixa provides potential advantages, including ease of storage and use. In the randomized, phase III FINISH-3 study, Raplixa plus gelatin sponge was superior to gelatin sponge alone in reducing the time to haemostasis in adults who developed mild or moderate bleeding uncontrolled by conventional surgical techniques while undergoing spinal, vascular, hepatic or soft-tissue surgical procedures. Raplixa was well tolerated, with a similar safety profile to that observed in the gelatin-sponge-alone group. Thus, Raplixa provides an easy
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TY - JOUR. T1 - CO2‐welded venous anastomosis. T2 - Enhancement of weld strength with heterologous fibrin glue. AU - Cikrit, Dolores F.. AU - Dalsing, Michael C.. AU - Weinstein, Todd S.. AU - Palmer, Kevin. AU - Lalka, Stephen G.. AU - Unthank, Joseph L.. PY - 1990. Y1 - 1990. N2 - The milliwatt CO2 laser was used to perform end‐to‐end anastomoses in canine jugular veins. There was a high disruption rate (50%) in laser‐welded veins (n = 10). Fibrin glue (n = 17), formed from human fresh‐frozen plasma, enhanced the weld strength decreasing the disruption rate (18%), resulting in an 82% patency which nearly equaled the contralateral sutured vein patency (93%). The bursting strength was improved with fibrin glue. Transmural necrosis was present initially in all groups but extended for a longer distance in the vessel wall in laser‐welded anastomoses. Sutured anastomoses exhibited a greater inflammatory response. In laser‐welded anastomoses endothelial cells were not as confluent as in ...
Transglutaminase aka meat glue. This stuff is used in a lot of formed meats, but some eateries are actually passing off formed steaks as the real deal!. ...
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Tisssue adhesive, sealants and glues market research report covering industry trends, market share, market growth analysis and projection by MIcroMarketMonitor.com. Tisssue adhesive, sealants and glues market report includes,|Key question answered| What are market estimates and forecasts; which of Tisssue adhesive, sealants and glues markets are doing well and which are not? and |Audience for this report| Tisssue adhesive, sealants and glues companies.
01-28-2012 01:56 PM by Sheila Landry (scrollgirl) , 32 comments ». Not too long ago, I did a blog which asked people what type of glue they liked best for different woodworking projects. Many people stated that they used white or tan wood glue for many of their gluing applications. I often use this type of glue too, not only for my scroll saw projects, but also for building smaller projects such as boxes and things of that nature. One problem that I had was application. Since I used the glue on smaller projects and only in small amounts, I found that t.... Read this review ». ...
Sutureless blepharoplasty or eyelid surgery uses fibrin adhesive. This is something that Ive specialised in, as I was one of the pioneers developing it.
Cleanup The most common mistake is using too much glue. The next most common mistake is trying to remove glue from skin areas without acetone. The worst case is to glue your fingers together, and that is easily fixed by applying acetone to the glue. A tissue, a cotton ball or a cotton swab (Q-Tip) will soften the glue enough to pull the fingers apart gently. It will take a few minutes, but its worth the time to avoid tearing skin. A more common cleanup is getting glue off the cuticle, where the back of the nail meets the skin on the finger. This can be done any time, but is slightly easier within 10 minutes of getting the glue on there in the first place. A cotton swab with just one drop of acetone is enough, because the acetone will spread outward toward the end of the nail, where the insert is. We want to keep the acetone away from that area, especially as the glue is hardening. Just keep putting one drop of acetone at a time at the back of the cuticle, keeping it wet, and the glue will ...
2P-10 Microtip, 25 pack. The FastCap 2P-10 Microtip is made to be used on the small 2.25 oz FastCap 2P-10 superglue bottles. These will give precise glue application.
This Report details the complete range of sealants & glues technologies used in traumatic, surgical and other wound closure, including tapes, sutures/staples/mechanical closure, hemostats, fibrin sealants/glues and medical adhesives. The report details current clinical and technology developments, with data on products in development (detailing market status) and on the market; market size and forecast; competitor market shares; competitor profiles; and market opportunity. The Report provides full year actual data from 2013 and, for available companies, quarterly data from 2014. The report provides a worldwide forecast to 2018 of the markets for these technologies, with particular emphasis on the market impact of new technologies through the forecast period. The report provides specific forecasts and shares of the worldwide market by segment for Americas (detail for U.S., Rest of North America and Latin America), Europe (detail for United Kingdom, German, France, Italy, Spain, Rest of Europe), ...
Sealants are quick and easy tooth-colored plastic coated resin coatings designed to fill little grooves in your teeth to prohibit bacteria buildup. The process is quite simple. Your dentist will clean your teeth, then apply a solution that will allow the sealant to stick tightly to the tooth. The first dental sealant to be placed is usually on the fissure of the first permanent molar tooth, once the chewing surface of the tooth has erupted completely beyond the gum. Your dentist will then paint the sealant on in a liquid form in hardens in just about a minute, and thats it! Best of all, studies have shown that sealants can reduce decay up to 70% and can last nearly a decade! ...
If you spill super glue on your Corian countertop, your first instinct may be to grab a cloth and wipe it up. Unfortunately, this will not work. Not only will rubbing or wiping spread the glue, by the time you grab a rag or paper towel, the glue will likely harden and dry to the countertop surface.
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Preformed tape sealants are tacky, deformable solids that are used under compression between two substrates in a variety of sealing applications. This ...
Our research was made on 23 patients who were able to obtain Tissucol from foreign countries and surgery in the same technique was applied to another group of 23 patients who approximately and the same pathology. Pure tonal audiometric tests were made to compare the gain in their hearig. It was observed that Tisscola made possible teh montage to be stable and elastic especially in type II and III tympanoplasties which needed the ossicules to be mounted. It was also used in myringoplasties in applying the graft without sliding. Tissucol was useful in stable fixation of autograft bone cartilage which was used in reconstruction of canalis acousticus externus in EPM+Tympanoplasties in order to prevent the depression of posterior superior wall. In type II tympanoplasties where Tissucol was applied there was a gain of 15 dB in hearing when compared to the controlle group. This research led to the conclusion that Tussucol was hard to be used in routine because it cantt be found in our country, it is ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。. To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of NTU Repository with Academic Hub to form NTU Scholars.. ...
I use sandpaper. Not the best thing, but it works. Gary in Wis On Nov 25, 2009, at 7:18 PM, Kay Springer wrote: , OK, I have managed to get a type of Krazy Glue on my fingers and , finally got them apart but now have stuff stuck all over my fingers. , Have tried acetone finger nail polish remover and it does not help. , Any suggestions? Just want I need before the holiday!!! LOL , , No one said I was Ms. Fix-it! Help! , , Kay Springer , www.showboatgsd.com , Home of Multi BISS & Multi Group Winning , Ch.Rohans Reward TC,CGC,HT,CD,RE,CHIC , Strider 69 BOBs #5 GSD , ============================================================================ , POST is Copyrighted 2009. All material remains the property of the original , author and of GSD Communication, Inc. NO REPRODUCTIONS or FORWARDS of any , kind are permitted without prior permission of the original author AND of the , Showgsd-l Management. ALL RIGHTS RESERVED. , , ALL PERSONS ARE ON NOTICE THAT THE FORWARDING, REPRODUCTION OR USE IN ANY , ...
False eyelashes enhance the thickness and length of natural lashes--as long as they remain in place. One article explores the variety of lash glues on the market and their overall
The Medicines Company is planning to sell its line of hemostasis products to Mallinckrodt Pharmaceuticals for up to $410 million as it aims to focus on core programs, including R&D for PCSK9 inhibition. Three products, Recothrom, a recombinant topical thrombin; PreveLeak, a surgical sealant; and Raplixa, a powder fibrin sealant, are included in the deal. Under a proposed agreement, The Medicines Company says it expects to receive an initial payment of about $175 million, including inventory. It also may receive up to $235 million in . . .
Instant Bond Glue , Find Complete Details about Instant Bond Glue,Instant Bond Glue,Contact Adhesive,Instant Bond Glue from Adhesives & Sealants Supplier or Manufacturer-Ningbo Yinzhou Bestwin Commodity Co., Ltd.
BARCELONA, Spain, June 19, 2019 /PRNewswire/ -- Grifols (MCE: GRF, MCE: GRF.P, NASDAQ: GRFS), one of the worlds three top providers of plasma-derived medicines to treat life-threatening diseases, today announced that the VISTASEAL(TM) fibrin sealant will be the first product it will introduce with Ethicon Inc. as part of a broad global relationship to provide plasma-protein-based solutions to manage surgical bleeding. Grifols developed VISTASEAL(TM), which combines two plasma proteins, fibrinogen and thrombin, and is administered with Ethicons airless spray device technology. The sealant, expected to be available in the second half of 2019, will be sold under the VISTASEAL(TM) name in the U.S. and VERASEAL(TM) in other select markets. Grifols is committed to applying its plasma leadership to its collaboration with Ethicon, whose strengths in device technology and market success in reaching millions of patients worldwide enable us to make important advances in biosurgery and the control of ...
What Kim says is true, but we have run slides thru H&E staining with good results. We normally etch the numbers on our slides before picking up sections. We dont use a label for H&E-stained slides but do for specials, immunos and ISH -stained slides. Those labels go on after the staining is done. Tim Morken CDC, Atlanta -----Original Message----- From: Kimberly Carter [mailto:[email protected]] Sent: Tuesday, July 31, 2001 9:40 AM Cc: Histonet Subject: Re: Slide labelling I have been using the DAKO labeling system for 2 years. One thing you need to be aware of is that although the writing on the label is resistant to solvents, the glue on the back of the label is not. You have to keep your levels of solutions low enough not to come into contact with the label, especially any xylene (This includes longer exposure to xylene fumes also). The glue becomes goo and will seep out and down the slide. Otherwise, I agree with Tim Morkens accessment of the label maker. Kim Carter OSU Medical Center ...
I recently acquired a Parker Fly with a crack in the finish thats been there for several years. I think they used some kind of poly finish. Its more plasticy than lacquer. Im not worried about how it looks now, but the edges of the finish seem to be getting a little loose and starting to peel back along the crack, and Im worried about it delaminating or flaking off at some point. I would like to do something to stabilize it, if that can be done without making it look worse. Im thinking about wicking in some thin CA glue, maybe with a needle injector, but I dont know much about poly finishes. If I get some CA glue on the top, how do I clean it up? Any ideas ...
We set up hide glue factory to produce pearl glue and industrial glue since 1996.Hide glue in pearl (Bone Glue) has a wide range of technical applications,such as fine furniture maker.
Your search for the ultimate super glue is over!. When you purchase Glue Masters Super Glue here is what you should do. When your package from Amazon arrives at your door, open it first chance you get. You now have in your hands 2oz bottle of the only ca glue solution that you will ever need.. Now go apply it! Even if you do not have an immediate project that you can use it on, we encourage you to go ahead and test it, because you will be amazed!. Perhaps that is why most renowned woodworkers always keep some of it in their toolkit. We use the best monomer resin that are purified by the most thorough distillation process. The highest degree of refinement is what makes all the difference, that is what allows our glue to work on the widest range of material.Ê. Its because of this we are able to make a guarantee unlike any that exists for this product type! We call it a Better Than Money Back Guarantee, and here it is:. Try out the GlueMasters CA Debonder for 60 days. If during that time you do ...
Your search for the ultimate super glue is over!. When you purchase Glue Masters Super Glue here is what you should do. When your package from arrives at your door, open it first chance you get. You now have in your hands 8oz bottle of the only ca glue solution that you will ever need.. Now go apply it! Even if you do not have an immediate project that you can use it on, we encourage you to go ahead and test it, because you will be amazed!. Perhaps that is why most renowned woodworkers always keep some of it in their toolkit. We use the best monomer resin that are purified by the most thorough distillation process. The highest degree of refinement is what makes all the difference, that is what allows our glue to work on the widest range of material.. Its because of this we are able to make a guarantee unlike any that exists for this product type! We call it a Better Than Money Back Guarantee, and here it is:. Try out the GlueMasters CA Debonder for 60 days. If during that time you do not feel ...
Affiliation (Current):大阪市立大学,大学院医学研究科,講師, Research Field:Orthopaedic surgery,Basic Section 56020:Orthopedics-related, Keywords:半月板,再生医療,半月修復,修復,再生,エストロゲン,軟骨代謝,ノックアウトマウス,cre-loxPシステム,ATDC5, # of Research Projects:8, # of Research Products:101, Ongoing Project:Cartilage repair covered with autologous fibrin sheet on microfracture
doi:10.1016/S0002-9610(01)00771-1. Spotnitz, William D.; Prabhu, Roshan (2005). "Fibrin Sealant Tissue Adhesive−Review and ... He is a notable researcher in the United States in use of fibrin glue (a surgical adhesive used to create hemostasis). Spotnitz ... "Tissue Sealants Usage Booming". Adhesives Age. October 1999. Retrieved October 9, 2017 - via Gale General OneFile. Murphy, ... He also previously served as the director of the hospital's Tissue Adhesive Center, which promoted and advanced the use of ...
A study conducted by researchers at the University of Alabama examined the adhesive properties of fibrin tissue adhesives. The ... of fibrin adhesives was on average 53.56 kPA. To seal together tissues the human body uses collagen and elastin to obtain ... and collagen fibers create much stronger bonds between tissues than strands of fibrin polymer. By generating adhesive proteins ... FGF-1 has been experimentally shown to encourage the body's own adhesive tissue to develop and effectively seal the wound ( ...
... this laboratory was devoted to the research and development of a fibrin glue and tissue adhesive that would close wounds in an ... a previous resident of Francis's current home who attempted to create an infallible tissue adhesive by experimenting on local ...
... enlargement of the spleen and too few neutrophils in the blood Fibrin sealant, a type of surgical tissue adhesive used during ...
This often causes inflammation and causes fibrin deposits onto the damaged tissues.[2] The fibrin then connects the two ... Adhesive capsulitis[edit]. In the case of adhesive capsulitis of the shoulder (also known as frozen shoulder), adhesions grow ... They may be thought of as internal scar tissue that connects tissues not normally connected. ... "Abdominal Adhesions (Scar Tissue)". Medicinenet. Retrieved 20 February 2014.. *^ Liakakos, T; Thomakos, N; Fine, PM; Dervenis, ...
A fibrin scaffold is a network of protein that holds together and supports a variety of living tissues. It is produced ... are essential due to mechanical stress and that can be achieved by combining them with natural biodegradable cell-adhesive ... Fibrin glue or fibrin sealant is also referred to as a fibrin based scaffold and used to control surgical bleeding, speed wound ... Fibrin scaffold is an important element in tissue engineering approaches as a scaffold material. It is advantageous opposed to ...
They can invade and damage nearby tissues and organs. Cancer cells can also metastasize (spread) from their original site to ... Its fibrinolytic capacity becomes insufficient and fibrin accumulates, causing fibrous adhesions between opposing surfaces. ... non-adhesive, and protective surface to facilitate intracoelomic movement. The mesothelium is also implicated in the transport ... Mesothelial hyperplasia Intra-abdominal adhesions: Normally, the mesothelium secretes plasminogen, which removes fibrin ...
Advantages of fibrin scaffoldEdit. Fibrin scaffold is an important element in tissue engineering approaches as a scaffold ... are essential due to mechanical stress and that can be achieved by combining them with natural biodegradable cell-adhesive ... Fibrin glue or fibrin sealant is also referred to as a fibrin based scaffold and used to control surgical bleeding, speed wound ... Ahmed TA, Dare EV, Hincke M (June 2008). "Fibrin: a versatile scaffold for tissue engineering applications". Tissue Engineering ...
The fibrin then connects the two adjacent structures where damage of the tissues occurred. The fibrin acts like a glue to seal ... In the case of adhesive capsulitis of the shoulder (also known as frozen shoulder), adhesions grow between the shoulder joint ... They may be thought of as internal scar tissue that connects tissues not normally connected. Adhesions form as a natural part ... The term "adhesion" is applied when the scar extends from within one tissue across to another, usually across a virtual space ...
Food and Drug Administration approves a new medical adhesive - a fibrin sealant called Artiss - for use in attaching skin ... June Spanish surgeon Paolo Macchiarini carries out the world's first tissue-engineered whole organ transplant, successfully ... "FDA OKs new adhesive to treat burn victims". medicalxpress.com. 2008-03-20. "3-D images - cordless and any time". Phys.org. ...
... and fibrin - adhesive coated collagen fleece (TachoComb) in liver surgery». In: «European IHPBA Congress „Athens' 95", 25 −28 ... Digest of acticles: hemostasis and tissue bonding". - «Nycomed Russia - Jpbureau". - Copenhagen - Moscow. - June, 2001. - p. 26 ... Severtsev A. «Different adhesive materials for hemostasis on the raw liver surface». // 4th Congress of the European Chapter of ... Severtsev A. N. "Fibrin glue and other hemostatic agents in liver surgery". Klinicheskiy Vestnik, July - September, 1996, pp. ...
Cosmetic companies are already using smaller tissue models to test new products on skin. The ability to 3-D print skin reduces ... Though PEG has been utilized in various 3D printing applications, the lack of cell-adhesive domains has limited further use in ... Materials for 3D printing usually consist of alginate or fibrin polymers that have been integrated with cellular adhesion ... Sacrificial writing into function tissue (SWIFT) is a method of organ printing where living cells are packed tightly to mimic ...
The results showed that MDP with fibrin tissue adhesive (FTA) and epineurial sutures were the best performing group among the ... After removal of scarred nerve tissue, the nerve is freed from surrounding soft tissues and its course may be shifted to allow ... Nerve tissue loss is associated with the more severe nerve injuries. 50-60% of sensory and motor neurons has been calculated ... Trauma to the nerve by cutting out each fascicle and fibrosis, a build up of tissue as a reaction, that develops due to the ...
"Strain-induced Collagen Organization at the Micro-level in Fibrin-based Engineered Tissue Constructs". Annals of Biomedical ... "Formation of focal adhesion-stress fibre complexes coordinated by adhesive and non-adhesive surface domains". IEE Proceedings ... "Strain-induced Collagen Organization at the Micro-level in Fibrin-based Engineered Tissue Constructs". Annals of Biomedical ... This phenomenon was discovered in 1912, and the terminology was introduced in 1945, but it is with the development of tissue ...
... collagen films act like a barrier membrane and are used to treat tissue infections like infected corneal tissue or liver cancer ... Gelatin polymer is often used on dressing wounds where it acts as an adhesive. Scaffolds and films with gelatin allow for the ... Polypeptides and proteins, are polymers of amino acids and some major examples include collagen, actin, and fibrin. ... Chitosan composite for tissue engineering: Blended power of Chitosan along with alginate are used together to form functional ...
Khiste SV, Naik Tari R (2013). "Platelet-Rich Fibrin as a Biofuel for Tissue Regeneration". ISRN Biomaterials. 2013: 1-6. doi: ... adhesives, absorbable agents, biologics, and combination of products (iii) Combination of both A resorbable haemostatic pack, ... The source of any bleeding can either be from soft tissues (gingiva and mucosa) or hard tissue (the bony socket). Bleeding of ... In a surgical extraction the dentist may elevate the soft tissues covering the tooth and bone, and may also remove some of the ...
doi:10.1007/s00441-012-1345-4. Man, Alan (2011). "Neurite Outgrowth in Fibrin Gels Is Regulated by Substrate Stiffness". Tissue ... It has also been shown that these adhesive cadherin molecules are internalized, and recycled by the migratory neuron. This ... This suggests that in addition to tissue repair, thy-1 might have roles in early CNS tissue development and organization. The ... Some have even proposed that L1CAM expression is elevated in vivo during tissue repair, which would support the notion that it ...
The cysts are carefully separated enough from surrounding tissue to be wrapped with fatty tissue or pericardial biomaterial to ... there have been multiple problems associated with the fibrin glue therapy including seepage of fibrin. It is no longer[when?] ... state that blood and its breakdown products acting as foreign-body substance in the subarachnoid space produce local adhesive ... Although fibrin-glue therapy initially had been thought to be a promising therapy in the treatment of these cysts, ...
"Nanoparticle solutions as adhesives for gels and biological tissues". Nature. 505 (7483): 382-385. doi:10.1038/nature12806. ... gelatin and fibrin. The crosslinks which bond the polymers of a hydrogel fall under two general categories: physical and ... This technique has seen considerable use in cell and tissue engineering applications due to the ability to inject or mold a ... Discher, D. E.; Janmey, P.; Wang, Y.L. (2005). "Tissue Cells Feel and Respond to the Stiffness of Their Substrate" (PDF). ...
Adhesives Dry glue Ejiao Fibrin glue Gelatin Isinglass Jell-O Neatsfoot oil Rendering (animal products) Rice glue Animal Glue ... These protein colloid glues are formed through hydrolysis of the collagen from skins, bones, tendons, and other tissues, ... "Animal Glue, Hot Melt Adhesive, Liquid Adhesive, Packaging Adhesive, Pur Glue, PVA Adhesives, Resin". L.D. Davis Industries. ... This adhesive is mostly used as glue, sizing, or varnish, although it is not as frequently used as other adhesives because it ...
The new tissue is not the same as the tissue that was lost. After the repair process has been completed, there is a loss in the ... Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss. ... or adhesive tape or glue. Primary intention can only be implemented when the wound is precise and there is minimal disruption ... This is due to wounds being created by major trauma in which there has been a significant loss in tissue or tissue damage. The ...
Skin grafting and tissue replacement for treating foot ulcers in people with diabetes PMID 26866804 https://doi.org/10.1002/ ... Done Fibrin glue versus sutures for conjunctival autografting in primary pterygium surgery PMID 27911983 https://doi.org/ ... Adhesives for bonded molar tubes during fixed brace treatment PMID 28230910 https://doi.org/10.1002/14651858.CD008236.pub3 ... Use of plastic adhesive drapes during surgery for preventing surgical site infection PMID 25901509 https://doi.org/10.1002/ ...
The new tissue is not the same as the tissue that was lost. After the repair process has been completed, there is a loss in the ... Fibrin and fibronectin cross-link together and form a plug that traps proteins and particles and prevents further blood loss.[ ... or adhesive tape or glue. ... Granulation tissue functions as rudimentary tissue, and begins ... After injury, structural tissue heals with incomplete or complete regeneration.[69][70] Whereas, tissue without an interruption ...
... tissue adhesives MeSH D27.720.222.410 - iron chelating agents MeSH D27.720.233.173 - chromogenic compounds MeSH D27.720.233.348 ... fibrin modulating agents MeSH D27.505.519.421.500 - antifibrinolytic agents MeSH D27.505.519.421.750 - fibrinolytic agents MeSH ...
Granulation tissue is the perfused, fibrous connective tissue that replaces a fibrin clot in healing wounds. It typically grows ... By producing anti-adhesive HA, HAS can allow tumor cells to release from the primary tumor mass, and if HA associates with ... The initial granulation tissue formed is highly inflammatory with a high rate of tissue turnover mediated by matrix degrading ... Cell migration is essential for the formation of granulation tissue.[26] The early stage of granulation tissue is dominated by ...
"Fibrin Tissue Adhesive" by people in Harvard Catalyst Profiles by year, and whether "Fibrin Tissue Adhesive" was a major or ... "Fibrin Tissue Adhesive" is a descriptor in the National Library of Medicines controlled vocabulary thesaurus, MeSH (Medical ... Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used ... Fibrin Tissue Adhesive*Fibrin Tissue Adhesive. *Adhesive, Fibrin Tissue. *Tissue Adhesive, Fibrin ...
The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery. Author(s): Kuo Chen*, I.M. Sechenov ... Levy, O.; Martinowitz, U.; Oran, A.; Tauber, C.; Horoszowski, H. The use of fibrin tissue adhesive to reduce blood loss and the ... Title:The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery ... "The Use of Fibrin-based Tissue Adhesives for Breast in Reconstructive and Plastic Surgery", Current Topics in Medicinal ...
title = "Tissue adhesives and fibrin glues: NOVEMBER 2003",. abstract = "Synthetic and biologic tissue glues have been used for ... Tissue adhesives and fibrin glues: NOVEMBER 2003. Bret Thomas Petersen, Alan Barkun, Steven Carpenter, Poonputt Chotiprasidhi, ... Tissue adhesives and fibrin glues : NOVEMBER 2003. / Petersen, Bret Thomas; Barkun, Alan; Carpenter, Steven; Chotiprasidhi, ... Tissue adhesives and fibrin glues : NOVEMBER 2003. In: Gastrointestinal Endoscopy. 2004 ; Vol. 60, No. 3. pp. 327-333. ...
Fibrin sealants (FS) derived from human plasma are frequently used in neurosurgery. In order to increase clot stability, FS ... Keywords: Epilepsy; antifibrinolytic agent; tissue adhesive. This is a preview of subscription content, log in to check access. ... Fibrin sealants (FS) derived from human plasma are frequently used in neurosurgery. In order to increase clot stability, FS ... Epileptic Seizures Following Cortical Application of Fibrin Sealants Containing Tranexamic Acid in Rats. ...
Tissue adhesives and fibrin glues: NOVEMBER 2003. Bret Petersen, Alan Barkun, Steven Carpenter, Poonputt Chotiprasidhi, Ram ... Dive into the research topics of Tissue adhesives and fibrin glues: NOVEMBER 2003. Together they form a unique fingerprint. ...
Harmonic scalpel is a ultrasonic vibrating scissors which makes it easy to cut and coagulate the tissues, thus reducing op time ... usage of fibrin sealant after surgery. Drug: Usage of Fibrin sealant Usage of 1 vial of fibrin sealant after hemostasis in ... Efficacy of Fibrin Sealant to Reduce the Amount of Post-thyroidectomy Drain. The safety and scientific validity of this study ... Fibrin sealant has been studied to reduce post-thyroidectomy drain and hospital stay as well. However, no strong evidence from ...
Fibrin Glue Versus Tacked Fixation in Groin Hernia Repair (TAPP). The safety and scientific validity of this study is the ... Fibrin Glue Versus Tacked Fixation in Laparoscopic Groin Hernia Repair. A Randomized Double-blind Placebo-controlled Trial.. ... In this study the researchers want to compare fibrin glue versus tacked fixation in fixation of the mesh in laparoscopic groin ... Tolver MA, Rosenberg J, Juul P, Bisgaard T. Randomized clinical trial of fibrin glue versus tacked fixation in laparoscopic ...
The Fibrin Pad Cardiovascular Study. The safety and scientific validity of this study is the responsibility of the study ... EVARREST™ Fibrin Sealant Patch is a sterile bio-absorbable combination product consisting of two constituent parts- a flexible ... EVARREST™ Fibrin Sealant Patch is a sterile bio-absorbable combination product consisting of two constituent parts- a flexible ... This is a three-arm, randomized multicenter study evaluating the safety and effectiveness of EVARREST™ Fibrin Sealant Patch in ...
... but it requires a significantly longer time for adhesive plug formation. ... Fibrin glue provides faster healing and induces significantly less corneal vascularization, ... Fibrin glue and cyanoacrylate tissue adhesive are both effective in the closure of corneal perforations up to 3 mm in diameter ... Conclusions: Fibrin glue and cyanoacrylate tissue adhesive are both effective in the closure of corneal perforations up to 3 mm ...
The use of overlay sutures and fibrin glue in DLK is a time efficient and effective technique. We propose that this technique ... Tissue Adhesives / therapeutic use* * Visual Acuity Substances * Fibrin Tissue Adhesive * Tissue Adhesives ... Overlay sutures and fibrin glue were used to secure the donor button and then a bandage contact lens was inserted. No sutures ... No sutures corneal grafting--a novel use of overlay sutures and fibrin glue in Deep Anterior Lamellar Keratoplasty Cont Lens ...
Other Fibrin Adhesive Products. Evicel, a fibrin adhesive made exclusively from human proteins, may avoid the risk of exposure ... Use of Fibrin Tissue Adhesive in Conjunctival, Corneal, Cataract, and Refractive Surgery. Published Online: February 28th 2011 ... Fibrin tissue adhesive has been in use for over 25 years for the repair of splenic and liver rupture, and as an adjunct in ... and both components of fibrin adhesive are placed in the interlamellar interface. The excess fibrin adhesive is squeegeed out ...
Comparison between suture and fibrin adhesive derived from snake venom for fixation of connective tissue graft in correction of ... Fibrin Sealant. Fibrin sealant is a biocompatible product, mainly of topical use, whose performance is based on fibrin ... Tissue Eng. 2002 Oct;8(5):787-98. [ Links ] 16. Clark RAF.Fibrin sealant in wound repair : a systematic survey of the ... The use of fibrin adhesive derived from snake venom and the evaluation of skin grafting using skin from the patients nasolabial ...
To evaluate potential clinical applications of nonautologous fibrin glue (FG) as a hemostatic agent in vascular surgery, we ... 0/Fibrin Tissue Adhesive; 0/Tissue Adhesives; 82347-53-3/Surgicel; 9001-31-4/Fibrin; 9001-32-5/Fibrinogen; 9002-84-0/ ... Fibrin*. Fibrin Tissue Adhesive. Fibrinogen*. Hemorrhage / etiology. Polytetrafluoroethylene*. Postoperative Complications. ... To evaluate potential clinical applications of nonautologous fibrin glue (FG) as a hemostatic agent in vascular surgery, we ...
Fibrin Tissue Adhesive / therapeutic use*. Follow-Up Studies. Humans. Male. Meningioma / surgery. Middle Aged. Pituitary ... CONCLUSIONS: Repair of the sellar floor with PGA sheet and fibrin glue is a safe and effective method to prevent postoperative ... RESULTS: Polyglactin acid sheets were adhered to the rabbit skin with fibrin glue within 3 minutes and withstood a pressure of ... METHODS: The sellar repair using absorbable PGA sheet and fibrin glue was applied to 18 consecutive patients with sellar tumors ...
Purpose: : The purpose of this study is to compare the safety and efficacy of fibrin tissue adhesive to suture conjunctival ... Conclusions: : In this interventional review of patients with glaucoma and cataracts, fibrin tissue adhesive compared to suture ... D.E. Baskin, W.J. Flynn, C.D. Reilly; Surgical Outcome Comparison of Fibrin Tissue Adhesive VersusSuture Conjunctival Wound ... Surgical Outcome Comparison of Fibrin Tissue Adhesive VersusSuture Conjunctival Wound Closure in Trabeculectomy ...
Adhesives and Tissue Sealants*Fibrin Sealants. *Collagen Based Sealants. *Cyanoacrylate Sealants. *Albumin and Glutaraldehyde ... The newer types of wound closure products such as adhesives and tissue sealants are gaining popularity, as they considerably ... Browse the full Wound Closure Products (Sutures, Surgical Staples, Wound Closure Strips, Adhesives and Tissue Sealants and ... The most commonly used would closure products are wound closure strips, staples, sutures, hemostats, adhesives, and tissue ...
Shukla J, Jain P. Preparation of autologous platelet-rich fibrin glue, an effective tissue adhesive in the haematology ... Preparation of autologous platelet-rich fibrin glue, an effective tissue adhesive in the haematology laboratory. ...
AUTOLOGOUS FIBRIN TISSUE ADHESIVE FOR CEREBROSPINAL FLUID LEAKS: A CONTROLLED STUDY OF NEUROTOXICITY. Feldman, Marc D.; ...
Full text: Available Index: LILACS (Americas) Main subject: Fibrin Tissue Adhesive / Cyanoacrylates / Flexural Strength Limits: ... Full text: Available Index: LILACS (Americas) Main subject: Fibrin Tissue Adhesive / Cyanoacrylates / Flexural Strength Limits: ... To evaluate rupture pressures of tissue adhesives of cyanoacrylate (Omnex®) and fibrin (Evicel®), used as reinforcement in ... Animals , Fibrin Tissue Adhesive/therapeutic use , Cyanoacrylates/therapeutic use , Flexural Strength/physiology , Sutures/ ...
To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total ... Effectiveness of autologous fibrin tissue adhesive in reducing postoperative blood loss during total hip arthroplasty: a ... PURPOSE: To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless ...
Fibrin Sealants. *Topical Thrombin Products. *Adhesive and Tissue Sealing Agents. *Natural Tissue Sealants ... which will increase the demand for hemostasis and tissue sealing agents. Hemostasis and tissue sealing agents are used to ... Latest industry research report on Hemostasis and Tissue Sealing Agents market. With the rising geriatric populations, due to ... Worldwide Hemostasis and Tissue Sealing Agents Market 2017- Strategy Resources, Manufacturers,Supply and Forecasts 2023. ...
Following extraction the remaining cryoprecipitate can advantageously be formed into a fibrin fabric used in surgeries and in ... Tissue adhesive US5919766A (en) 1999-07-06. Composition comprising coagulation factor VIII formulation, process for its ... A61L24/00-Surgical adhesives or cements; Adhesives for colostomy devices * A61L24/04-Surgical adhesives or cements; Adhesives ... "fibrin sealant" or "fibrin glue" or "fibrin fabric". ... The fibrin/fibrinogen material can also be reinforced by ...
... tissue sealant and adhesion barrier products which helps the surgeons ... ... The hemostasis and tissue sealing agents market involves the study of wide range of hemostat, ... Adhesive and Tissue Sealing Agents. Natural Tissue Sealant. Fibrin Sealant. Other Natural Sealant (Albumin and Collagen based ... Adhesive and tissue sealant are classified into natural tissue sealant, synthetic tissue sealant and adhesion barrier products ...
Persistence Market Research presents a detailed study of the Tissue Glue and Bio-adhesive Sealants Market titled Tissue Glue ... and Bio-adhesive Sealants Market: Global Industry Analysis and Forecast, 2016-2024. This study demonstrates the market ... Global Market Study on Tissue Glue and Bio-adhesive Sealants. ... Fibrin Sealant. Gelatin-based Sealants. Others. By Region. ... Figure 8 : Global Tissue Glue and Bio-adhesive Sealants Market Absolute $ Opportunity By Fibrin Sealants, 2016-2024 ...
doi:10.1016/S0002-9610(01)00771-1. Spotnitz, William D.; Prabhu, Roshan (2005). "Fibrin Sealant Tissue Adhesive−Review and ... He is a notable researcher in the United States in use of fibrin glue (a surgical adhesive used to create hemostasis). Spotnitz ... "Tissue Sealants Usage Booming". Adhesives Age. October 1999. Retrieved October 9, 2017 - via Gale General OneFile. Murphy, ... He also previously served as the director of the hospitals Tissue Adhesive Center, which promoted and advanced the use of ...
Tissue adhesives (including fibrin based). Medical device. Toothpastes for sensitive teeth where the mode of action is physical ...
Helping you find trustworthy answers on Tissue Adhesive , Latest evidence made easy ... Find all the evidence you need on Tissue Adhesive via the Trip Database. ... The evaluation of fibrin sealants and tissue adhesives in oral surgery among patients with bleeding disorders. (PubMed). The ... surgical adhesives, and tissue adhesives.There are numerous articles on sutures, surgical tape, and tissue adhesives, but there ...
Fibrin Tissue Adhesive. An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. The commercial product ... Mixing of the two components promotes BLOOD CLOTTING and the formation and cross-linking of fibrin. The tissue adhesive is used ... In vivo, fibrinopeptide A is used as a marker to determine the rate of conversion of fibrinogen to fibrin by thrombin. ... It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the ...
Biocompatible [MeSH]; Tissue scaffolds [MeSH]; Tissue adhesives [MeSH]; Fibrin Tissue Adhesive [MeSH]; Blood patch, Epidural [ ... For supportive devices- Search title: Supportive devices - meshes, patches and tissue adhesives: Search terms: Surgical mesh [ ... Regulation of platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and conditioned serum ...
  • An autologous or commercial tissue adhesive containing FIBRINOGEN and THROMBIN. (harvard.edu)
  • Embolization also can occur from intravascular injection of thrombin or fibrin glue. (elsevier.com)
  • There are insufficient data to support routine endoscopic use of the available preparations of cyanoacrylate, fibrin glue, and thrombin in clinical practice. (elsevier.com)
  • EVARREST™ Fibrin Sealant Patch is a sterile bio-absorbable combination product consisting of two constituent parts- a flexible matrix and a coating of two biological components (Human Fibrinogen and Human Thrombin). (clinicaltrials.gov)
  • If slower polymerization is desired for ease of use or complicated procedures, the thrombin portion of fibrin adhesive can be diluted 1:10 or even 1:100 with balanced saline solution (BSS). (touchophthalmology.com)
  • Fibrinogen/thrombin-coated collagen patch (TachoSil®) is known to have the effect of strengthening tissue anastomosis and promoting suturing to prevent leakage. (bioportfolio.com)
  • Thrombin is massively released upon tissue damage associated with bleeding or chronic inflammation. (bioportfolio.com)
  • The question of the effects of such thrombin on tissue regrowth and repair has been scarcely address. (bioportfolio.com)
  • Compared to fibrin sealants, the collective revenues generated from sales of protein-based sealants and thrombin-based sealants in the global market are projected to secure over 40% value share by the end of 2024. (medgadget.com)
  • 6. The cartridge of claim 1 , wherein the matrix comprises one of fibrin or thrombin. (google.es)
  • A fibrin-stabilizing plasma enzyme (TRANSGLUTAMINASES) that is activated by THROMBIN and CALCIUM to form FACTOR XIIIA. (curehunter.com)
  • Attaching IOL haptics to the sclera using plasma-derived fibrin glue 1 , 2 has been demonstrated, although potential drawbacks include the use of human blood products, handling difficulties of the fibrinogen-thrombin mixture, potential interactions of the thrombin in the glue with endogenous fibrinogen in the sclera, which may compromise the fibrotic healing needed to hold the lens in place after the glue degrades. (arvojournals.org)
  • All fibrin sealants in use as of 2003 have two major ingredients, purified fibrinogen (a protein) and purified thrombin (an enzyme) derived from human or bovine (cattle) blood. (surgeryencyclopedia.com)
  • At the end of the cascade, the thrombin breaks up the fibrinogen molecules into smaller segments of a second blood protein called fibrin. (surgeryencyclopedia.com)
  • Isolation of the human thrombin by affinity chromatography for an utilisation in the preparations of fibrin glue" Ann. (patents.com)
  • Severe Bleeding due to Factor V Inhibitor after Repeated Operations Using Fibrin Sealant containing Bovine Thrombin," W. Muntean, W. Zenz, G. Edlinger, and A Beitzke, Thrombosis and Haemostasis, 77:1223 (1997). (patentgenius.com)
  • Staindl O (1979) The Healing of Wounds and Scar Formation under the Influence of a Tissue Adhesion System with Fibrinogen, Thrombin and Coagulation Factor XIII. (springer.com)
  • Thus, the interplay of all coagulation (clotting) factors leads to the formation of active thrombin, which, in turn, activates hemostatic fibrin. (healthcanal.com)
  • However, thrombin also contributes to the formation of new blood vessels and is able to dissolve the extracellular matrix, which is the adhesive that keeps cells together. (healthcanal.com)
  • Thrombin may thus make it easier for cancer cells to invade surrounding tissue. (healthcanal.com)
  • Fibrin consists of the blood proteins fibrinogen and thrombin which participate in blood clotting . (wikipedia.org)
  • Fibrin gel characterization by scanning electron microscopy reveals that thick fibers make up a dense structure at lower fibrinogen concentrations (5 mg/ml) and thinner fibers and looser gel can be obtained as fibrinogen concentration (20 mg/ml) increases whereas increase in thrombin concentration (from 0.5 U/ml to 5 U/ml) has no such significant result although the fibers steadily get thinner. (wikipedia.org)
  • In this regard, much effort by the Center for the Study of Venoms and Venomous Animals (CEVAP) has been made to produce a new fibrin sealant that uses a serine protease from a Brazilian snake ( Crotalus durissus terrificus ) with thrombin-like activity. (hindawi.com)
  • To describe a case where Deep Anterior Lamellar Keratoplasty (DLK) was performed using overlay sutures and fibrin glue alone, without the need to directly suture the corneal button. (nih.gov)
  • Overlay sutures and fibrin glue were used to secure the donor button and then a bandage contact lens was inserted. (nih.gov)
  • No sutures were required to directly suture the donor button to host tissue. (nih.gov)
  • The use of overlay sutures and fibrin glue in DLK is a time efficient and effective technique. (nih.gov)
  • Out of the aforementioned, tissue sealants are used with staples or sutures in specific surgical procedures. (mynewsdesk.com)
  • Sutures, needles, and tissue adhesives: a review for dermatologic surgery. (tripdatabase.com)
  • The global market for wound closure products on the basis of product type into surgical staples, adhesive and tissue sealants, sutures, and hemostats. (transparencymarketresearch.com)
  • This information is based on the findings of a research report published by Transparency Market Research (TMR), titled "Wound Closure Products (Sutures, Surgical Staples, Wound Closure Strips, Adhesives and Tissue Sealants and Hemostats) Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2015 - 2023. (transparencymarketresearch.com)
  • In body regions where damage and bleeding must be avoided, a substitute for mechanical tissue fixation by sutures or staplers is needed. (nih.gov)
  • Background: Fibrin-based biological adhesives are used for tissue adhesion improving the outcome of gastrointestinal sutures. (sciencepublishinggroup.com)
  • Tissue adhesives of different types had been used in previous studies to attach conjunctival grafts and compared with the use of sutures were associated with a shorter operative time and reduced postoperative complaints. (thefreedictionary.com)
  • To overcome these problems, investigators have suggested the use of laser suture lysis 1 or releasable sutures 2 or other types of closure methods, such as staples, tapes and adhesives. (bmj.com)
  • The use of tissue adhesives instead of sutures in ophthalmic surgery was first proposed in the 1960s ( 1 ). (ispub.com)
  • In a previous study the superior rectus muscle of rabbits was recessed 5 mm and reattached to the sclera with octyl 2-cyanoacrylate adhesive instead of sutures ( 2 ). (ispub.com)
  • Products used in wound closure include sutures, surgical staples, wound closure strips, adhesives and tissue sealants, and hemostats. (sbwire.com)
  • Various surgical procedures such as aortic valve replacement and peripheral bypass employ combination of sutures or staples as well as tissue adhesives. (sbwire.com)
  • Increased prevalence of lifestyle diseases such as diabetes and cardiovascular diseases and reluctance in the use of sutures due to development of scars and high risk of infection are the other factors driving the adhesives and tissue sealants segment. (sbwire.com)
  • Fibrin glue or fibrin sealant is also referred to as a fibrin based scaffold and used to control surgical bleeding, speed wound healing , seal off hollow body organs or cover holes made by standard sutures , and provide slow-release delivery of medications like antibiotics to tissues exposed. (wikipedia.org)
  • Synthetic and biologic tissue glues have been used for control of bleeding and closure of fistulas and anastomotic leaks. (elsevier.com)
  • GI endoscopic applications of cyanoacrylate and fibrin glues are considered "off-label" uses. (elsevier.com)
  • Ginsberg, Gregory G. / Tissue adhesives and fibrin glues : NOVEMBER 2003 . (elsevier.com)
  • The growing demand for advances and highly effective adhesives continues to influence manufacturers to develop alternative glues and cementing materials. (medgadget.com)
  • Fibrin sealants are also called fibrin glues. (surgeryencyclopedia.com)
  • In 1997, the Tissue Adhesive Center was founded at the University of Virginia Health Sciences Center in order to develop and test new fibrin sealants and other surgical glues. (surgeryencyclopedia.com)
  • Fibrin glues are fast acting and biodegradable but have relatively poor adhesion strength. (psu.edu)
  • Cyanoacrylate adhesives -- super glues -- offer strong adhesion, rapid setting time and strong adhesion to tissue, but they degrade slowly and may cause toxicity, often limiting their use to external applications. (psu.edu)
  • Previous studies have shown that even topical application of some cyanoacrylates result in tissue toxicity. (uic.edu)
  • The most commonly investigated materials include cyanoacrylates and fibrin glue sealants. (google.co.uk)
  • The use of cyanoacrylates requires meticulous tissue preparation and, despite improvements in compound synthesis, concerns with both aldehyde biocompatibility and local inflammatory response still exist. (google.co.uk)
  • Fibrin sealants are, however, being replaced for some specialized purposes by newer wound adhesives known as cyanoacrylates. (surgeryencyclopedia.com)
  • The tissue adhesive is used for tissue sealing, HEMOSTASIS, and WOUND HEALING. (harvard.edu)
  • Objective: This review addresses the action of fibrin agents and their effect on the quality of surgical hemostasis. (eurekaselect.com)
  • Worldwide Hemostasis and Tissue Sealing Agents Market 2017- Strategy Resources, Manufacturers,Supply and Forecasts 2023. (beforeitsnews.com)
  • Latest industry research report on Hemostasis and Tissue Sealing Agents market . (beforeitsnews.com)
  • With the rising geriatric populations, due to several age related conditions, there will be more surgical procedures, which will increase the demand for hemostasis and tissue sealing agents. (beforeitsnews.com)
  • Hemostasis and tissue sealing agents are used to prevent hemorrhage. (beforeitsnews.com)
  • This has created the need for hemostasis and tissue sealing agents. (beforeitsnews.com)
  • The increasing number of surgeries, introduction of multi-usage and ready-to-use products along with the global rise in geriatric populations supplement the growth of the global hemostasis and tissue sealing agents market during the analysis period. (beforeitsnews.com)
  • Recently, the FDA has approved numerous hemostatic products that would further drive the growth of global hemostasis and tissue sealing agents market. (beforeitsnews.com)
  • He is a notable researcher in the United States in use of fibrin glue (a surgical adhesive used to create hemostasis). (wikipedia.org)
  • The hemostasis and tissue sealing agents market involves the study of wide range of hemostat, tissue sealant and adhesion barrier products which helps the surgeons to control bleeding during the surgery. (reportlinker.com)
  • The market of hemostasis and tissue sealing agents is witnessing positive growth due to the introduction of technology advanced and cost effective hemostat and tissue sealing products by key companies. (reportlinker.com)
  • The company also offers wide range of hemostasis and tissue sealant products such as RESORBA, ActivHeal and LiquiBand. (reportlinker.com)
  • Other factors such as aging population and rising number surgical procedures further drive the growth of the hemostasis and tissue sealing agents market globally. (reportlinker.com)
  • All these factors collectively fuel the revenues of hemostasis and tissue sealing agents market during the study period, hence boost market growth. (reportlinker.com)
  • Hemostasis and tissue sealing agents market have been majorly segmented into types of products. (reportlinker.com)
  • Geographically, the global hemostasis and tissue sealing agents market has been segmented into four major regions namely North America, Europe, Asia Pacific and Rest of the World (RoW). (reportlinker.com)
  • This section also covers market attractiveness analysis and event impact analysis of the global hemostasis and tissue sealing agents market. (reportlinker.com)
  • Fibrin sealants have several advantages over older methods of hemostasis (stopping bleeding). (surgeryencyclopedia.com)
  • These results suggest that fibrin sealant, in addition to assisting in the achievement of hemostasis, exerts biological effects on human peritoneal mesothelial cells and fibroblasts and modulates MMP expression. (deepdyve.com)
  • This segment is categorized into two major type namely topical hemostats and adhesive and tissue sealant products. (reportlinker.com)
  • Market size data for Wound Closure Devices market segments - Hemostats, Tissue Adhesives, Tissue Sealants, Ligating Clips, Surgical Stapling Devices, Surgical Adhesion Barriers and Wound Closure Strips. (pitchengine.com)
  • Topics include the integrity of microvascular anastomoses, tissue adhesion, and the incidence of seromas and hematomas associated with fibrin glue usage. (eurekaselect.com)
  • Adhesive and tissue sealant are classified into natural tissue sealant, synthetic tissue sealant and adhesion barrier products. (reportlinker.com)
  • The use of cyanoacrylate adhesives (CA) for tissue adhesion is well documented in the literature. (uic.edu)
  • To examine whether Tisseel, a fibrin sealant, exerts an effect on expression of MMPs from human peritoneal mesothelial cells, normal peritoneal fibroblasts, and adhesion fibroblasts, a tissue culture study was conducted for 6, 12, 24, and 48 h under normoxic conditions. (deepdyve.com)
  • Thus, fibrin sealant may influence tissue remodeling and may thereby be able to alter postoperative adhesion development. (deepdyve.com)
  • On the basis of product, the biosurgery is broadly segmented into bone-graft substitutes, soft-tissue attachments, hemostatic agents, surgical sealants and adhesives, adhesion barriers, and staple-line reinforcement agents. (marketresearch.com)
  • Key determinants of sealant efficacy include the strength and duration of tissue-material adhesion, as well as material biocompatibility. (scirp.org)
  • Staindl O (1979) Tissue Adhesion with Highly Concentrated Human Fibrinogen in Otolaryngology. (springer.com)
  • The existing surgical adhesives are not ideal for wet tissue adhesion required in many surgeries such as those for internal organs. (elsevier.com)
  • Developing surgical adhesives with strong wet tissue adhesion, controlled degradability and mechanical properties, and excellent biocompatibility has been a significant challenge. (elsevier.com)
  • Within the formulations investigated, iCMBAs showed 2.5-8.0 folds stronger wet tissue adhesion strength over the clinically used fibrin glue, demonstrated controlled degradability and tissue-like elastomeric mechanical properties, and exhibited excellent cyto/tissue-compatibility both in vitro and in vivo. (elsevier.com)
  • iCMBAs were able to stop bleeding instantly and suturelessly, and close wounds (2 cm long × 0.5 cm deep) created on the back of Sprague-Dawley rats, which is impossible when using existing gold standard, fibrin glue, due to its weak wet tissue adhesion strength. (elsevier.com)
  • Biomaterials made up of fibrin can attach many biological surfaces with high adhesion. (wikipedia.org)
  • The iCMBAs provided 2.5 to 8.0 times stronger adhesion in wet tissue conditions compared to fibrin glue. (psu.edu)
  • GelCORE revealed higher tissue adhesion compared to commercial adhesives. (sciencemag.org)
  • Hemostatic Agents and Tissue Sealants: Potential Mimics of Abdominal Abnormalities. (harvard.edu)
  • Fibrin adhesives are hemostatic agents that reproduce the last steps of the coagulation cascade. (escrs.org)
  • Our results support that iCMBA technology is highly translational and could have broad impact on surgeries where surgical tissue adhesives, sealants, and hemostatic agents are used. (elsevier.com)
  • In recent decades bio-adhesives, tissue sealants and hemostatic agents became the favored products to control bleeding and promote tissue healing after surgery. (psu.edu)
  • Effectiveness of autologous fibrin tissue adhesive in reducing postoperative blood loss during total hip arthroplasty: a prospective randomised study of 100 cases. (eewoww.com)
  • PURPOSE: To evaluate the effectiveness of autologous fibrin tissue adhesive (auto-FTA) in reducing blood loss during cementless total hip arthroplasty (THA). (eewoww.com)
  • Developing Surgical Techniques: The Role of Fibrin Sealants. (wikipedia.org)
  • The role of fibrin sealants (surgical tissue adhesives) to reduce postoperative pancreatic fistula after pancreatic surgery is controversial. (cochrane.org)
  • To compare the efficacy of fibrin glue and N-butyl-2-cyanoacrylate in corneal perforations. (nih.gov)
  • The rheological gel point determination showed that the mixture of ELA-NCO/DMSO and chitosan chloride offers a time window large enough to readjust the fused joint during surgery, as opposed to fibrin glue. (nih.gov)
  • It is a measure of the conversion of FIBRINOGEN to FIBRIN, which is prolonged by AFIBRINOGENEMIA, abnormal fibrinogen, or the presence of inhibitory substances, e.g., fibrin-fibrinogen degradation products, or HEPARIN. (bioportfolio.com)
  • and optionally heating said second fraction within one of the containers of the container system so as to dissolve the isolated precipitated tissue repair promoting substances. (google.ca)
  • Furthermore, fractions comprising tissue repair promoting substances derived from blood cells may be isolated within the container system, said fractions optionally being combined with the second fraction comprising tissue repair promoting substances derived from blood plasma. (google.ca)
  • 1. A tissue repair promoting composition comprising tissue repair promoting substances isolated from plasma and tissue repair promoting substances isolated from platelets, the tissue repair promoting substances isolated from plasma including at least fibrinogen, the composition being substantially free of fibrin. (google.ca)
  • 2. The composition of claim 1 wherein the tissue repair promoting substances isolated from plasma further include factor XIII and fibronectin. (google.ca)
  • 3. The composition of claim 1 wherein the tissue repair promoting substances isolated from platelets include at least one growth factor. (google.ca)
  • 4. The composition of claim 3 wherein the tissue repair promoting substances isolated from platelets include platelet-derived growth factor, epidermal growth factor or both. (google.ca)
  • 5. The composition of claim 1 wherein the tissue repair promoting substances isolated from platelets include platelet factors 1-4. (google.ca)
  • 12. The composition of claim 1 wherein the tissue repair promoting substances are isolated from the plasma and platelets of a single human or animal. (google.ca)
  • Blood also enables hormones and other substances to be transported between tissues and organs. (wikibooks.org)
  • Tissue sealants composed of polymers and bioengineered substances, along with alginate, foam, collagen and growth factor wound dressings, will exhibit the fastest gains based on safe and effective healing properties. (freedoniagroup.com)
  • On the contrary, reconnection of transected stumps by using biocompatible sealants may significantly facilitate the process, as well as taking the advantage of employing the adhesive as scaffold to engraft stem cells, as well as neurotrophic substances, to the injury site. (hindawi.com)
  • Multicentric clinical trials will be required to evaluate the efficacy of fibrin sealant to treat chronic ulcers, as well as to validate the proteomic strategies to assess prognosis. (scielo.br)
  • Vasconez, L.O. Experimental and clinical applications of fibrin glue. (eurekaselect.com)
  • Fibrin glue and cyanoacrylate tissue adhesive are both effective in the closure of corneal perforations up to 3 mm in diameter. (nih.gov)
  • Fibrin glue provides faster healing and induces significantly less corneal vascularization, but it requires a significantly longer time for adhesive plug formation. (nih.gov)
  • To show the utility of intracameral fibrin glue in corneal perforation. (escrs.org)
  • These adhesives are biocompatible, biodegradable and with low toxicity for corneal surfaces. (escrs.org)
  • The use of these adhesives in the anterior chamber is an useful and easily solution for treating small corneal perforation. (escrs.org)
  • For a small self-sealing corneal laceration, a bandage adhesive soft contact lens may be applied for approximately 3-6 weeks. (medscape.com)
  • Fibrin glue has been found to be a safe and effective alternative to suture in some cases of corneal lacerations. (medscape.com)
  • More than 1.5 million new cases of corneal blindness are reported every year ( 1 ), of which only less than 5% are treated by corneal transplantations due to donor tissue shortage and the high expense of transplantation surgery ( 2 ). (sciencemag.org)
  • When the two parts are combined intra-operatively, the final stages of the coagulation cascade are initiated, and a strong, dense, cross-linked fibrin clot forms in about one minute. (touchophthalmology.com)
  • This clot adheres to rough (but not epithelialized) wound surfaces, and allows the gluing of tissues. (touchophthalmology.com)
  • It is important for stabilizing the formation of the fibrin polymer (clot) which culminates the coagulation cascade. (curehunter.com)
  • The Fibrin Sealant (FS) is an additional clot of human origin. (dentalxp.com)
  • The ingredients in these sealants interact during application to form a stable clot composed of a blood protein called fibrin. (surgeryencyclopedia.com)
  • The fibrin molecules arrange themselves into strands that are then cross-linked by a blood factor known as Factor XIII to form a lattice or net-like pattern that stabilizes the clot. (surgeryencyclopedia.com)
  • Quixil (Omrix Biopharmaceuticals, Ramat Gan, Israel) is a human fibrin sealant consisting of two biological components that form a clot within 30 s of placement on the tissue surface. (bmj.com)
  • Together, when activated, their interaction mimics the coagulation cascade, forming a stable and adhesive clot [ 22 ]. (hindawi.com)
  • The tests found that fibrin adhesives even at its intended medical concentration (29 mg/mL at the wound site) had shear strength of only 17.6 kiloPascals. (wikipedia.org)
  • German researchers have found that fibrin sealants containing Factor XIII generally give better results than those that do not. (surgeryencyclopedia.com)
  • This study demonstrates the market dynamics and trends globally across the five regions of North America, Latin America, Europe, APAC and MEA which influence the current nature and future status of the Tissue Glue and Bio-adhesive Sealants market over the forecast period. (bccresearch.com)
  • In this report, Persistence Market Research gives an overall view of the global Tissue Glue and Bio-adhesive Sealants market and also throws light on the market sentiment and overall segments of this market. (bccresearch.com)
  • The period of assessment of this report is for eight years and this report enlightens the clients on the crucial aspects of the global Tissue Glue and Bio-adhesive Sealants market in the coming decade. (bccresearch.com)
  • The report gives a detailed description of the effect these drivers and restraints will have on the global Tissue Glue and Bio-adhesive Sealants market and this gives a crystal clear picture to clients regarding how the market will shape up in the future. (bccresearch.com)
  • This research report provides detailed analysis of the global Tissue Glue and Bio-adhesive Sealants market and offers insights on the various factors driving market popularity. (bccresearch.com)
  • The report starts with an overview of the global Tissue Glue and Bio-adhesive Sealants market in terms of value. (bccresearch.com)
  • In addition, this section includes analysis of key trends, drivers and restraints from the supply, demand and economy side, which are influencing the global Tissue Glue and Bio-adhesive Sealants market. (bccresearch.com)
  • The next section of the report highlights the growth trends of the global Tissue Glue and Bio-adhesive Sealants market by region. (bccresearch.com)
  • It provides a market outlook for 2016-2024 and sets the forecast within the context of the global Tissue Glue and Bio-adhesive Sealants market. (bccresearch.com)
  • The study discusses key regional trends contributing to the growth of the Tissue Glue and Bio-adhesive Sealants market worldwide, as well as analyses the extent to which drivers are influencing this market in each region. (bccresearch.com)
  • The above sections - by product type, by application, by end user and by region - evaluate the present scenario and future growth prospects of the global Tissue Glue and Bio-adhesive Sealants market for the period 2016 - 2024. (bccresearch.com)
  • In the final section of the report, Persistence Market Research has included a competitive landscape to provide clients with a dashboard view based on categories of providers in the value chain, presence in the global Tissue Glue and Bio-adhesive Sealants market portfolio and key differentiators. (bccresearch.com)
  • This section is primarily designed to provide clients with an objective and detailed comparative assessment of key providers specific to a market segment in the global Tissue Glue and Bio-adhesive Sealants market value chain and the potential players for the same. (bccresearch.com)
  • Detailed profiles of providers are also included in the scope of the report to evaluate their long-term and short-term strategies, key offerings and recent developments in the global Tissue Glue and Bio-adhesive Sealants market. (bccresearch.com)
  • In 2015, the global sales of tissue glue and bio-adhesive sealants have been recorded to exceed US$ 1.1 billion, indicating a promising scope of growth in terms of revenues. (medgadget.com)
  • According to Persistence Market Research's recent report titled " Tissue Glue and Bio-adhesive Sealants Market: Global Industry Analysis & Forecast, 2016-2024" global revenues will reach US$ 2,281.2 million by the end of 2024. (medgadget.com)
  • Local and regional pharmaceutical manufacturers have been actively participating in the global tissue glue and bio-adhesive sealants market , collectively accounting for 14%-15% market share. (medgadget.com)
  • With over 40% company share, Ethicon (US) has independently expanded its outright dominance in the global tissue glue and bio-adhesive sealants market. (medgadget.com)
  • Product-wise breakdown of global tissue glue and bio-adhesive sealants sales recorded throughout the forecast period have indicated higher demand for fibrin sealants. (medgadget.com)
  • The market size of the global tissue glue and bio-adhesive sealants market spans several key regions that endure distinctive growth throughout the forecast period. (medgadget.com)
  • North America's tissue glue and bio-adhesive sealants market is estimated to dominate with more than 50% share of global market value. (medgadget.com)
  • Technological influence and enhanced healthcare infrastructure are attributed to promote the growth of the tissue glue and bio-adhesive sealants market in North America. (medgadget.com)
  • Meanwhile, qualitative production and an extensive consumer base has rendered Asia Pacific (APAC) as the second most lucrative region in the global tissue glue and bio-adhesive sealants market. (medgadget.com)
  • The report titled Global Tissue Glue and Bio-adhesive Sealants Market 2020 by Manufacturers, Regions, Type and Application, Forecast to 2025 is a far-reaching review of the market size and trends with values. (pharmiweb.com)
  • It offers a board interpretation of the global Tissue Glue and Bio-adhesive Sealants industry from a range of information that is collected through reputable and verified sources. (pharmiweb.com)
  • The study additionally demonstrates the market rivalry scene and a relating point by point investigation of the significant merchant/producers in the global Tissue Glue and Bio-adhesive Sealants market. (pharmiweb.com)
  • The worldwide Tissue Glue and Bio-adhesive Sealants market is any segmental into types, applications, technology, end-users, business verticals, and key geographies. (pharmiweb.com)
  • The global Tissue Glue and Bio-adhesive Sealants market report offers detailed analysis supported by reliable statistics on sale and revenue by players for the period 2015-2020. (pharmiweb.com)
  • Gogly, B. Platelet-rich fibrin (PRF): a second-generation platelet concentrate. (eurekaselect.com)
  • IMSEAR at SEARO: Preparation of autologous platelet-rich fibrin glue, an effective tissue adhesive in the haematology laboratory. (who.int)
  • Shukla J, Jain P. Preparation of autologous platelet-rich fibrin glue, an effective tissue adhesive in the haematology laboratory. (who.int)
  • The principles of guided tissue and bone regeneration are covered in detail, including many recent advancements in barrier membrane technologies as well as use of platelet-rich fibrin and various growth factors, and many next-generation materials that will optimize future bone and periodontal regeneration are presented. (vuestroslibros.com)
  • Numerous surgical adhesive materials introduced bronchoscopically, thoracoscopically, or by direct tissue application, have been used in an attempt to control bronchopleural fistulas (BPF). (google.co.uk)
  • Reports that have been published between 2001 and 2003 indicate that fibrin sealants are a safe and highly effective form of surgical adhesive. (surgeryencyclopedia.com)
  • A silastic strip (3 mm wide, 4 mm long, 0.5 mm thick) was grasped with thin forceps, and both sides were spread with a thin layer of octyl 2-cyanoacrylate surgical adhesive. (ispub.com)
  • The conjunctiva was then repositioned and reattached using a small amount of surgical adhesive. (ispub.com)
  • Sellar repair with resorbable polyglactin acid sheet and fibrin glue in endoscopic endonasal transsphenoidal surgery. (biomedsearch.com)
  • METHODS: The sellar repair using absorbable PGA sheet and fibrin glue was applied to 18 consecutive patients with sellar tumors that include 13 pituitary adenomas, 2 craniopharyngiomas, 2 Rathke's cleft cysts, and 1 meningioma within 135 patients who were treated with endoscopic endonasal transsphenoidal approach. (biomedsearch.com)
  • CONCLUSIONS: Repair of the sellar floor with PGA sheet and fibrin glue is a safe and effective method to prevent postoperative CSF leakage, which decreases the necessity for lumbar drainage after the operation. (biomedsearch.com)
  • During the surgery, the area of the air leak at the aspergilloma was covered with a polyglycolic acid sheet and fibrin tissue adhesive. (omicsonline.org)
  • This is a three-arm, randomized multicenter study evaluating the safety and effectiveness of EVARREST™ Fibrin Sealant Patch in controlling mild to moderate vascular anastomosis suture line bleeding in cardiovascular surgery. (clinicaltrials.gov)
  • The purpose of this study is to compare the safety and efficacy of fibrin tissue adhesive to suture conjunctival fornix-based flap wound closure in trabeculectomy surgery. (arvojournals.org)
  • 18 eyes of 18 patients with fibrin tissue adhesive conjunctival flap closure are compared to 20 eyes of 20 patients who underwent the same procedure except with suture conjunctival flap closure. (arvojournals.org)
  • In this interventional review of patients with glaucoma and cataracts, fibrin tissue adhesive compared to suture conjunctival wound closure in combined cataract extraction surgery and trabeculectomy procedures represents an equally effective technique with comparable postoperative IOP and bleb leaks and with the advantages of less postoperative discomfort and shorter operating times. (arvojournals.org)
  • To evaluate rupture pressures of tissue adhesives of cyanoacrylate (Omnex®) and fibrin (Evicel®), used as reinforcement in colonic suture from "ex vivo" swine . (bvsalud.org)
  • Patients in which a biological fibrin-based biological adhesive was applied to the suture line (study group) were compared versus a control group under standard practice. (sciencepublishinggroup.com)
  • The iCMBAs could eventually be used in a wide range of surgical disciplines from suture and staple replacement to tissue grafts to treat hernias, ulcers and burns. (psu.edu)
  • Advances in less invasive surgery and tissue sealants will weaken the overall US market for traditional suture and staple wound closures. (freedoniagroup.com)
  • A method for making an adhesive for use in joining soft living tissue including the steps of preparing a hydroxyl-terminated polyester by reacting a biodegradable monomer with a polyhydroxy polymerization initiator in the presence of an amount up to about 2.0 weight percent of a catalyst, and then preparing. (google.com)
  • Development of a biodegradable tissue adhesive based on functionalized 1,2-ethylene glycol bis(dilactic acid). (nih.gov)
  • Fibrin scaffold has many aspects like being biocompatible , biodegradable and easily processable. (wikipedia.org)
  • Flexible adhesive composition according to any one of the preceding claims, characterized in that the polysaccharide has wound-healing and / or procoagulant properties. (google.com.au)
  • Amniotic membrane is a unique tissue graft that is capable of promoting wound healing through sophisticated biological pathways, Scheffer C.G. Tseng, MD, PhD, a leader in the biologics industry, said. (healio.com)
  • Conversely, polymers based on natural compounds, most notably fibrin, are biocompatible in the context of internal applications. (scirp.org)
  • It is avascular and biocompatible with multiple tissue types on the ocular surface. (healio.com)
  • Fibrin sealant has been applied in neurosurgery for decades, being effective and biocompatible, with no side effects to the nervous system microenvironment [ 21 ]. (hindawi.com)
  • Commercially, only the homologous fibrin sealants obtained from human blood are available, which are highly efficient but very expensive. (scielo.br)
  • This study examines the use of AlloDerm in conjuction with a homologous fibrin tissue adhesive for dural repair. (uic.edu)
  • Evicel, a fibrin adhesive made exclusively from human proteins, may avoid the risk of exposure to bovine blood proteins. (touchophthalmology.com)
  • Objectives of the study were (1) to compare the total number of transfusions and the length of hospital stay in patients undergoing complete revision hip arthroplasty (RHA) with and without the use of a fibrin sealant (EVICEL®) and (2) to evaluate the possible role in cost savings of EVICEL® in association with the blood-saving protocol. (springer.com)
  • In all of them we introduced the fibrin tissue adhesive (Tissucol®, Baxter Labs) using a 27 G needle. (escrs.org)
  • Fibrin Tissue Adhesive" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
  • In this study the researchers want to compare fibrin glue versus tacked fixation in fixation of the mesh in laparoscopic groin hernia repair. (clinicaltrials.gov)
  • Polymeric tissue sealants, along with alginate, foam, and collagen wound dressings, will realize the fastest growth based on enhanced safety and faster healing properties. (freedoniagroup.com)
  • Factor XIII is a compound that strengthens blood clots by forming cross-links between strands of fibrin. (surgeryencyclopedia.com)
  • With the commercial availability in the last two decades of fibrin adhesives that include the plasmin inhibitor aprotinin, fibrin has seen rapidly growing use in anterior segment surgery. (touchophthalmology.com)
  • Interestingly, in mesothelial cells, TIMP-1 mRNA levels were reduced by fibrin-sealant-containing aprotinin at both concentrations, while being further reduced by fibrin sealant without aprotinin, particularly at 6 and 12 h. (deepdyve.com)
  • Fibrin adhesive was first popularized in pterygium surgery with conjunctival autografts using a technique described by Koranyi in 2004. (touchophthalmology.com)
  • 15,16,17) The conjunctival grafts were positioned leaving no open scleral tissue starting from the nasal and temporal limbus, with the epithelial side up and the limbal area aligned with the limbus. (thefreedictionary.com)
  • Anterior segment photograph 7 days after trabeculectomy surgery with fibrin adhesive, showing a diffuse active filtering bleb, with local conjunctival hyperaemia. (bmj.com)
  • Eye rubbing causing conjunctival graft dehiscence following pterygium surgery with fibrin glue. (medscape.com)
  • This segment is inclusive of collagen-based sealants, polymer-based sealants, fibrin sealants, albumin and glutaraldehyde sealants, and cyanoacrylate-based sealants. (mynewsdesk.com)
  • Natural tissue sealant comprises fibrin sealant and others (albumin and collagen based tissue sealant). (reportlinker.com)
  • Adhesives and tissue sealants include fibrin sealants, collagen-based sealants, cyanoacrylate-based sealants, albumin and glutaraldehyde sealants, and polymer-based sealants. (sbwire.com)
  • The literature on fibrin adhesives with respect to prevention of postoperative complications, and the effectiveness with active drainage also are analyzed. (eurekaselect.com)
  • Cerebrospinal fluid (CSF) leaks are considered serious complications in transsphenoidal pituitary surgery and efficient tissue sealing is an important preventive measure. (springer.com)
  • Conclusions: The use of these adhesives could not only reduce serious postoperative complications related to dehiscence but also improve the prognosis and oncological outcome of rectal and sigmoid cancer treatment. (sciencepublishinggroup.com)
  • Each biomedical application has its own characteristic requirement for different kinds of tissues and recent studies with fibrin scaffold are promising towards faster recovery, less complications and long-lasting solutions. (wikipedia.org)
  • To assess the safety, effectiveness , and potential adverse effects of fibrin sealants for the prevention of postoperative pancreatic fistula following pancreatic surgery. (cochrane.org)
  • Fibrin glue sealing of polytetrafluoroethylene vascular graft anastomoses: comparison with oxidized cellulose. (biomedsearch.com)
  • To evaluate potential clinical applications of nonautologous fibrin glue (FG) as a hemostatic agent in vascular surgery, we compared its efficacy to oxidized regenerated cellulose (OC) in hemostatically sealing polytetrafluoroethylene (PTFE) vascular graft anastomoses. (biomedsearch.com)
  • Cartilage tissue is frequently used as a graft implant material for a variety of facial plastic and reconstructive cases. (uic.edu)
  • The approval of Artiss can help surgeons using a fibrin sealant to fine tune graft placement on burn sites," said Jesse L. Goodman, M.D., M.P.H., director of FDA's Center for Biologics Evaluation and Research. (ohsonline.com)
  • In this surgical video, Dr Moghaddas will demonstrate an implant placement in a ridge with large concavity at the buccal aspect and reconstruction of the deficient area with freeze dried bone allograft, Neobiotech Ti-membrane, and thickening the soft tissue with dermal graft. (dentalxp.com)
  • In Group III, the graft material was maintained in the defect throughout the experimental period and inducing the amount of periodontal tissue regeneration was higher than other groups. (koreamed.org)
  • These results suggest that the use of fibrin tissue adhesive in conjunction with porous resorbable calcium carbonate would improves the stability of graft material and inhibit the epithelial down growth and make it be a feasible method for periodontal regeneration. (koreamed.org)
  • The objective was to assess the effectiveness of fibrin-based biological adhesives for prevention of anastomotic leakage in high-risk gastrointestinal anastomoses. (sciencepublishinggroup.com)
  • Synthetic sealant includes cyanoacrylate based tissue sealant and others (polyethylene glycol and others). (reportlinker.com)
  • We included all randomized controlled trials that compared fibrin sealant group (fibrin glue or fibrin sealant patch) versus control group (no fibrin sealant or placebo ) in people undergoing pancreatic surgery. (cochrane.org)
  • abstract = "Background and Purpose: Urinary-tract fistulas present unique clinical challenges that often necessitate open surgical excision with interposition of healthy tissue. (northwestern.edu)
  • These enzymes degrade key proteins that make up the tissue network of the lungs (Shapiro et al. (google.com)
  • Diamond, Michael 2006-02-01 00:00:00 Matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs) are important in regulating tissue remodeling of extracellular matrix. (deepdyve.com)
  • Fibrin gels can be enriched by addition of other extracellular matrix (ECM) components such as fibronectin , vitronectin , laminin and collagen . (wikipedia.org)
  • 5. The method of claim 1 , wherein the collagen-containing material comprises a remodelable extracellular matrix sheet material obtained in sheet form from a collagenous tissue source, the remodelable extracellular matrix sheet material effective to stimulate cellular invasion and ingrowth into the remodelable extracellular matrix sheet material upon implantation in the body of a patient. (google.de)
  • Objective: To examine the potential efficacy of Crosseal (the human protein, bovine component-free fibrin sealant) (OMRIX Biopharmaceuticals, Ltd, Brussels, Belgium) to reduce ecchymoses and hematoma formation in patients undergoing rhytidectomy. (elsevier.com)
  • 7. The method of claim 1 further comprising the step of applying said prepolymer adhesive to soft living tissue whereupon said prepolymer adhesive is hydrolyzed to promote chain growth and cross linking to effect bonding to said tissue. (google.com)
  • Additional mechanical properties can be obtained by combining fibrin with other suitable scaffolds. (wikipedia.org)
  • Flexible adhesive composition according to claim 1, characterized thereby that the adhesive in the body is resorbable. (google.com.au)
  • The purpose of this study was to evaluate the effect of fibrin tissue adhesive and porous resorbable calcium carbonate on the periodontal regeneration of the class II furcation defect in dogs. (koreamed.org)
  • The newer types of wound closure products such as adhesives and tissue sealants are gaining popularity, as they considerably reduce the time taken for healing and would closure. (mynewsdesk.com)
  • Surgical repair of dural tears may require the use of replacement tissues in situations where there is inadequate dura remaining for closure over the brain. (uic.edu)
  • Increased application of tissue sealants in surgeries such as bariatric surgeries and dental surgeries has fueled the wound closure products market. (sbwire.com)
  • Mussels can be a mouthwatering meal, but the chemistry that lets mussels stick to underwater surfaces may also provide a highly adhesive wound closure and more effective healing from surgery. (psu.edu)
  • Fibrin tissue adhesive has been in use for over 25 years for the repair of splenic and liver rupture, and as an adjunct in cardiac surgery. (touchophthalmology.com)
  • Tisseel maintains its adhesive properties for about one week after surgery. (touchophthalmology.com)
  • He also previously served as the director of the hospital's Tissue Adhesive Center, which promoted and advanced the use of adhesives in surgery. (wikipedia.org)
  • Dermatologic surgery generally requires the removal of offending or excessive tissue followed by repair of the resultant defect. (tripdatabase.com)
  • An adhesive with remarkable strength could be ideal for patching people up after surgery. (newscientist.com)
  • Dr. Geraghty has conducted research on autologous fibrin tissue adhesives and post-op pain control in Head & Neck Surgery. (medicinenet.com)
  • Is surgical tissue adhesive able to reduce postoperative pancreatic fistula after pancreatic surgery? (cochrane.org)
  • Based on the observations in the nine trials included in this review , it appears that fibrin sealants do not prevent postoperative pancreatic fistula in people undergoing pancreatic surgery. (cochrane.org)
  • Based on the current available evidence, fibrin sealants do not seem to prevent postoperative pancreatic fistula in people undergoing pancreatic surgery. (cochrane.org)
  • However, the use of fibrin sealants during pancreatic surgery is controversial. (cochrane.org)
  • In the immediate post-surgery period, the amniotic membrane remained in position and the chamber was reshaped with the tissue adhesive covering the perforation on its endothelial side. (escrs.org)
  • Inhibitor to Factor V after Exposure to Fibrin Sealant During Cardiac Surgery in a Two-Year-Old Child," W. Muntean, W. Zenz, K. Finging, G. Zobel, and A Beitzke, Acta Paediatr, 83:84-7 (1994). (patentgenius.com)
  • It is also used to support local tissues in glaucoma bleb surgery, strabismus surgery and orbital reconstruction. (healio.com)
  • Jesús Lago Oliver, Salvador Argudo Garijo, Mauricio Burneo Esteves, Irene Arjona Medina, Mercedes Sanz Sánchez, Jorge Martín Gil, Fernando Turégano Fuentes, Antonio Torres García, Fibrin-based Biological Adhesives Prevent Anastomotic Leakage in Rectal Anastomoses: Prospective Multicentre Randomised Clinical Trial, Journal of Surgery . (sciencepublishinggroup.com)
  • Additionally, neither product is effective when used on wet tissue, a requirement of internal organ surgery, nor are there any current commercially available tissue adhesives or sealants appropriate for both external and internal use. (psu.edu)
  • Additionally, although open surgical excision of urinary-tract fistulae remains the gold standard treatment, endoscopic injection of fibrin glue offers a safe, minimally invasive approach that may avoid the morbidity of open surgery in such challenging patients. (northwestern.edu)
  • Biocompatibility of a Self-adhesive Gutta-percha-based Material in Subcutaneous Tissue of Mice. (tripdatabase.com)
  • The purpose of this study was to evaluate the biocompatibility of a self- adhesive gutta-percha material and compare it with that of conventional gutta-percha.Standard quantities of bioactive gutta-percha and conventional gutta-percha were directly inserted subcutaneously into the dorsal connective tissue of 30 BALB/c mice according to ISO 10993-6. (tripdatabase.com)
  • Additionally, the in vitro and in vivo biocompatibility studies of the adhesive system revealed no toxic effects on the surrounding tissue. (nih.gov)
  • Results show that while bioadhesion to a range of soft tissue surfaces (porcine aortic adventitia, renal artery adventitia, renal cortex, and pericardium) varies with isoreactive manipulation, general indicators of material biocompatibility remain constant. (scirp.org)
  • 1] [2] [3] Irrespective of specific use, the safety and efficacy of these materials largely depend on sufficient adherence to soft tissue surfaces, adequate residence time at the site of application, and acceptable biocompatibility. (scirp.org)
  • The bio-adhesives, called iCMBAs, adhere well in wet environments, have controlled degradability, improved biocompatibility and lower manufacturing costs, putting them a step above current products such as fibrin glue and cyanoacrylate adhesives. (psu.edu)
  • We reviewed our experience with endoscopic injection of fibrin glue for the treatment of urinary-tract pathology. (northwestern.edu)
  • Patients and Methods: We performed a retrospective review of the eight patients at our institution who have undergone retrograde endoscopic injection of fibrin glue for the treatment of urinary-tract pathology. (northwestern.edu)
  • Conclusion: Retrograde endoscopic injection of fibrin glue offers a novel approach to ablation of caliceal diverticula. (northwestern.edu)
  • Turk, Thomas M T. / Endoscopic injection of fibrin glue for the treatment of urinary-tract pathology . (northwestern.edu)
  • The staples are driven through the matrix to secure the matrix to tissue. (google.es)
  • Dryden GW, Boland E, Yajnik V, Williams S. Comparison of Stromal Vascular Fraction with or Without a Novel Bioscaffold to Fibrin Glue in a Porcine Model of Mechanically Induced Anorectal Fistula. (harvard.edu)
  • Weniger M, D'Haese JG, Crispin A, Angele MK, Werner J, Hartwig W. Autologous but not Fibrin Sealant Patches for Stump Coverage Reduce Clinically Relevant Pancreatic Fistula in Distal Pancreatectomy: A Systematic Review and Meta-analysis. (harvard.edu)
  • and (4) securing the collagen matrix hemostatic pad to the tissue sorrounding the fistula. (google.co.uk)
  • A fistula occurs when the reconnection does not heal properly, creating a leak of pancreatic juice from the pancreas to the abdominal tissues. (cochrane.org)
  • All lesions except the urethrocutaneous fistula and the ureterorectal fistula were treated with a single injection of fibrin glue. (northwestern.edu)
  • Many surgeons will then discard the needle and dispense the adhesive parts onto the eye directly from the hub of the syringe. (touchophthalmology.com)
  • A survey done in 2000 at the University of Virginia hospital found that over 90% of the surgeons who had tried fibrin sealants were pleased with the results. (surgeryencyclopedia.com)
  • Autologous fibrin glue (a new method of preparation)" Surgical Forum (41st Annual Forum on Fundamental Surgical Problems Held at the 71st Annual Clinical Congress of the American College of Surgeons, Chicago) 36:544-547 (1985). (patents.com)
  • Treatment of 213 Patients with Symptomatic Tarlov Cysts by CT-Guided Percutaneous Injection of Fibrin Sealant. (harvard.edu)
  • The first experimentation with fibrin in ocular tissue was in 1978, 1 and the first use of fibrin in human patients was to repair injuries to the lens. (touchophthalmology.com)
  • The Food and Drug Administration on March 19 approved Artiss, a fibrin sealant that will adhere to skin grafts for adult and pediatric burn patients. (ohsonline.com)
  • Patients were randomized according to which side of the rhytidectomy the tissue sealant was placed. (elsevier.com)
  • For his contributions in the "development of tissue adhesives for surgical use", Spotnitz was inducted into the 2004 class of the College of Fellows of the American Institute for Medical and Biological Engineering. (wikipedia.org)
  • A System for the Separation into Fractions of the Protein and Lipoprotein Components of Biological Tissues and Fluids," Cohn et al. (patentgenius.com)
  • Yang, along with University of Texas-Arlington researchers Mohammadreza Mehdizadeh, Hong Weng, Dipendra Gyawali and Liping Tang, took the biological information and developed a wholly synthetic family of adhesives. (psu.edu)
  • Currently, the most commonly used fibrin-based adhesive in ophthalmology is Tisseel VH Fibrin Sealant (Baxter BioSurgery, Deerfield, Illinois), whose use in ophthalmic applications is considered off-label. (touchophthalmology.com)
  • Before use, Tisseel adhesive requires about 20 minutes of warming in a heating device provided without charge by Baxter. (touchophthalmology.com)
  • Fibrin sealants are undergoing rapid refinement as the result of recent advances in tissue adhesives in general. (surgeryencyclopedia.com)
  • A fibrin scaffold is a network of protein that holds together and supports a variety of living tissues. (wikipedia.org)
  • They can hold on tightly without getting flushed away by the waves because the mussel can make a very powerful adhesive protein. (psu.edu)
  • We looked at the chemical structure of that kind of adhesive protein. (psu.edu)
  • They incorporated the chemical structure from the mussel's adhesive protein into the design of an injectable synthetic polymer. (psu.edu)
  • There occur synthetic adhesive materials like hyaluronic acid, regenerated cellulose, polyethylene glycol and natural adhesive materials like collagen & protein and fibrin. (visiongain.com)
  • Dermal fibroblasts are cells within the dermis layer of skin which are responsible for generating connective tissue and allowing the skin to recover from injury. (wikipedia.org)
  • Using organelles (particularly the rough endoplasmic reticulum), dermal fibroblasts generate and maintain the connective tissue which unites separate cell layers. (wikipedia.org)
  • Furthermore, dermal fibroblasts create long fibrous bands of connective tissue which anchor the skin to the fascia of the body. (wikipedia.org)
  • Using FGF stimulate fibroblast activity is a more effective means of sealing tissue than current tissue sealants due to the robust nature of collagen which makes up connective tissue. (wikipedia.org)
  • In Group II, fibrin adhesive was absorbed at 2 week specimens, and connective tissue attachment increased than that of control group. (koreamed.org)
  • Anatomically, blood is considered a connective tissue, due to its origin in the bones and its function. (wikibooks.org)