Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.
A voluntary organization concerned with the prevention and treatment of heart and vascular diseases.
The heart of the fetus of any viviparous animal. It refers to the heart in the postembryonic period and is differentiated from the embryonic heart (HEART/embryology) only on the basis of time.
The heart rate of the FETUS. The normal range at term is between 120 and 160 beats per minute.
The study of the heart, its physiology, and its functions.
The hollow, muscular organ that maintains the circulation of the blood.
Pathological conditions involving the HEART including its structural and functional abnormalities.
Pathological processes involving any part of the LUNG.
A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of PULMONARY ALVEOLI that extends to the interstitium and beyond leading to diffuse PULMONARY FIBROSIS. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features.
Either of the pair of organs occupying the cavity of the thorax that effect the aeration of the blood.
Morphological and physiological development of FETUSES.
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.
The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.
The mass or quantity of heaviness of an individual at BIRTH. It is expressed by units of pounds or kilograms.
Studies in which subsets of a defined population are identified. These groups may or may not be exposed to factors hypothesized to influence the probability of the occurrence of a particular disease or other outcome. Cohorts are defined populations which, as a whole, are followed in an attempt to determine distinguishing subgroup characteristics.
The introduction of error due to systematic differences in the characteristics between those selected and those not selected for a given study. In sampling bias, error is the result of failure to ensure that all members of the reference population have a known chance of selection in the sample.
An aspect of personal behavior or lifestyle, environmental exposure, or inborn or inherited characteristic, which, on the basis of epidemiologic evidence, is known to be associated with a health-related condition considered important to prevent.
The relative amounts of the PURINES and PYRIMIDINES in a nucleic acid.
A branch of internal medicine concerned with the diagnosis and treatment of INFECTIOUS DISEASES.
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Time period from 1801 through 1900 of the common era.
Books designed to give factual information or instructions.
Collections of systematically acquired and organized information resources, and usually providing assistance to users. (ERIC Thesaurus, accessed 2/1/2008)
The failure of a FETUS to attain its expected FETAL GROWTH at any GESTATIONAL AGE.
Conditions or pathological processes associated with pregnancy. They can occur during or after pregnancy, and range from minor discomforts to serious diseases that require medical interventions. They include diseases in pregnant females, and pregnancies in females with diseases.
The co-occurrence of pregnancy and a cardiovascular disease. The disease may precede or follow FERTILIZATION and it may or may not have a deleterious effect on the pregnant woman or FETUS.
A condition in pregnant women with elevated systolic (>140 mm Hg) and diastolic (>90 mm Hg) blood pressure on at least two occasions 6 h apart. HYPERTENSION complicates 8-10% of all pregnancies, generally after 20 weeks of gestation. Gestational hypertension can be divided into several broad categories according to the complexity and associated symptoms, such as EDEMA; PROTEINURIA; SEIZURES; abnormalities in BLOOD COAGULATION and liver functions.
Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; SPONTANEOUS ABORTION; INDUCED ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO.
A publication issued at stated, more or less regular, intervals.
Infectious organisms in the BLOOD, of which the predominant medical interest is their contamination of blood-soiled linens, towels, gowns, BANDAGES, other items from individuals in risk categories, NEEDLES and other sharp objects, MEDICAL WASTE and DENTAL WASTE, all of which health workers are exposed to. This concept is differentiated from the clinical conditions of BACTEREMIA; VIREMIA; and FUNGEMIA where the organism is present in the blood of a patient as the result of a natural infectious process.
The act or practice of calling public attention to a product, service, need, etc., especially by paid announcements in newspapers, magazines, on radio, or on television. (Random House Unabridged Dictionary, 2d ed)
Infections by bacteria, general or unspecified.
Instruments or technological means of communication that reach large numbers of people with a common message: press, radio, television, etc.
One of the three domains of life (the others being Eukarya and ARCHAEA), also called Eubacteria. They are unicellular prokaryotic microorganisms which generally possess rigid cell walls, multiply by cell division, and exhibit three principal forms: round or coccal, rodlike or bacillary, and spiral or spirochetal. Bacteria can be classified by their response to OXYGEN: aerobic, anaerobic, or facultatively anaerobic; by the mode by which they obtain their energy: chemotrophy (via chemical reaction) or PHOTOTROPHY (via light reaction); for chemotrophs by their source of chemical energy: CHEMOLITHOTROPHY (from inorganic compounds) or chemoorganotrophy (from organic compounds); and by their source for CARBON; NITROGEN; etc.; HETEROTROPHY (from organic sources) or AUTOTROPHY (from CARBON DIOXIDE). They can also be classified by whether or not they stain (based on the structure of their CELL WALLS) with CRYSTAL VIOLET dye: gram-negative or gram-positive.
A syndrome of HEMOLYSIS, elevated liver ENZYMES, and low blood platelets count (THROMBOCYTOPENIA). HELLP syndrome is observed in pregnant women with PRE-ECLAMPSIA or ECLAMPSIA who also exhibit LIVER damage and abnormalities in BLOOD COAGULATION.
Errors in metabolic processes resulting from inborn genetic mutations that are inherited or acquired in utero.
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver. The abnormal lipid accumulation is usually in the form of TRIGLYCERIDES, either as a single large droplet or multiple small droplets. Fatty liver is caused by an imbalance in the metabolism of FATTY ACIDS.
Organic, monobasic acids derived from hydrocarbons by the equivalent of oxidation of a methyl group to an alcohol, aldehyde, and then acid. Fatty acids are saturated and unsaturated (FATTY ACIDS, UNSATURATED). (Grant & Hackh's Chemical Dictionary, 5th ed)
Pathological processes of the LIVER.
The major component of hemoglobin in the fetus. This HEMOGLOBIN has two alpha and two gamma polypeptide subunits in comparison to normal adult hemoglobin, which has two alpha and two beta polypeptide subunits. Fetal hemoglobin concentrations can be elevated (usually above 0.5%) in children and adults affected by LEUKEMIA and several types of ANEMIA.
A disease characterized by chronic hemolytic anemia, episodic painful crises, and pathologic involvement of many organs. It is the clinical expression of homozygosity for hemoglobin S.
The oxygen-carrying proteins of ERYTHROCYTES. They are found in all vertebrates and some invertebrates. The number of globin subunits in the hemoglobin quaternary structure differs between species. Structures range from monomeric to a variety of multimeric arrangements.
An abnormal hemoglobin resulting from the substitution of valine for glutamic acid at position 6 of the beta chain of the globin moiety. The heterozygous state results in sickle cell trait, the homozygous in sickle cell anemia.
Normal adult human hemoglobin. The globin moiety consists of two alpha and two beta chains.
The condition of being heterozygous for hemoglobin S.
Hemoglobins characterized by structural alterations within the molecule. The alteration can be either absence, addition or substitution of one or more amino acids in the globin part of the molecule at selected positions in the polypeptide chains.
Disorders of the blood and blood forming tissues.
A family of blood flukes of the class Trematoda which is found in animals and man. It Includes the genera Heterobilharzia, Schistosomatium, Schistosoma, Ornithobilharzia, Bilharziella, Trichobilharzia, Pseudobilharzia, and Austrobilharzia.
Genes that cause the epigenotype (i.e., the interrelated developmental pathways through which the adult organism is realized) to switch to an alternate cell lineage-related pathway. Switch complexes control the expression of normal functional development as well as oncogenic transformation.
The study of microorganisms such as fungi, bacteria, algae, archaea, and viruses.
All of the divisions of the natural sciences dealing with the various aspects of the phenomena of life and vital processes. The concept includes anatomy and physiology, biochemistry and biophysics, and the biology of animals, plants, and microorganisms. It should be differentiated from BIOLOGY, one of its subdivisions, concerned specifically with the origin and life processes of living organisms.

Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease. (1/1979)

Impaired glucose metabolism in Down's syndrome (DS) has been well-documented in vivo, although information on the underlying biochemical defect is limited and no biochemical studies on glucose handling enzymes have been carried out in the brain. Through gene hunting in fetal DS brain we found an overexpressed sequence homologous to the phosphoglycerate kinase (PGK) gene. This finding was studied further by investigating the activity levels of this key enzyme of carbohydrate metabolism in the brains of patients with DS. PGK activity was determined in five brain regions of nine patients with DS, nine patients with Alzheimer's disease and 14 controls. PGK activity was significantly elevated in the frontal, occipital and temporal lobe and in the cerebellum of patients with DS. PGK activity in corresponding brain regions of patients with Alzheimer's disease was comparable with controls. We conclude that our findings complement previously published data on impaired brain glucose metabolism in DS evaluated by positron emission tomography in clinical studies. Furthermore, we show that in DS, impaired glucose metabolism, represented by increased PGK activity, is a specific finding rather than a secondary phenomenon simply due to neurodegeneration or atrophy. These observations are also supported by data from subtractive hybridization, showing overexpressed PGK in DS brains at the transcriptional level early in life.  (+info)

Can transvaginal fetal biometry be considered a useful tool for early detection of skeletal dysplasias in high-risk patients? (2/1979)

OBJECTIVE: To evaluate the possibility of an early diagnosis of skeletal dysplasias in high-risk patients. METHODS: A total of 149 consecutive, uncomplicated singleton pregnancies at 9-13 weeks' amenorrhea, with certain menstrual history and regular cycles, were investigated with transvaginal ultrasound to establish the relationship between femur length and menstrual age, biparietal diameter and crown-rump length, using a polynomial regression model. A further eight patients with previous skeletal dysplasias in a total of 13 pregnancies were evaluated with serial examinations every 2 weeks from 10-11 weeks. RESULTS: A significant correlation between femur length and crown-rump length and biparietal diameter was found, whereas none was observed between femur length and menstrual age. Of the five cases with skeletal dysplasias, only two (one with recurrent osteogenesis imperfecta and one with recurrent achondrogenesis) were diagnosed in the first trimester. CONCLUSIONS: An early evaluation of fetal morphology in conjunction with the use of biometric charts of femur length against crown-rump length and femur length against biparietal diameter may be crucial for early diagnosis of severe skeletal dysplasias. By contrast, in less severe cases, biometric evaluation appears to be of no value for diagnosis.  (+info)

Comparison of prenatal ultrasound and postmortem findings in fetuses and infants with congenital heart defects. (3/1979)

OBJECTIVE: Detection of congenital heart defects by prenatal ultrasound examination has been one of the great challenges since the investigation for fetal anomalies became part of the routine fetal examination. This prospective study was designed to evaluate the concordance of prenatal ultrasound findings with autopsy examination in a population consisting of both referred women and non-selected pregnant women. DESIGN: Criteria for inclusion were an ultrasound examination at the National Center for Fetal Medicine and an autopsy performed during the years 1985-94. Results from the ultrasound and autopsy examinations were systematized into categories depending on the degree of concordance. RESULTS: Of 408 infants and fetuses with developmental anomalies, 106 (26%) had congenital heart defects. In 63 (59%) of these 106 cases, the heart defect was the principal reason for the termination of pregnancy or the cause of death. Excluding five cases with a secundum atrial septal defect, there was complete agreement between the ultrasound examination and the autopsy findings in 74 (73%) of 101 cases. In 18 cases, there were minor discrepancies between ultrasound and autopsy findings. The main diagnosis was thus correct in 92 cases (91%). From the first time period (1985-89) to the second (1990-94), the detection rate of all heart defects increased from 48% to 82%. CONCLUSION: This study confirms a good correlation between ultrasound and autopsy diagnoses in fetuses and infants with congenital heart defects. A significant improvement in the detection of heart defects occurred from the first time period to the second and was probably due to increased experience and technical advances.  (+info)

Diagnosis of twin reversed arterial perfusion sequence in the first trimester by transvaginal color Doppler ultrasound. (4/1979)

A case of twin reversed arterial perfusion (TRAP) sequence was diagnosed at 12 weeks' gestation using transvaginal color Doppler ultrasound, which demonstrated the presence of retrograde perfusion in the umbilical artery of the abnormal twin. Ultrasound imaging showed a monochorionic-diamniotic twin pregnancy with an inappropriately grown second twin, the morphological evaluation of which revealed an abnormal cephalic pole with acrania, diffuse subcutaneous edema and the presence of cardiac activity in an abnormal heart with a single chamber.  (+info)

Amylopectinosis in fetal and neonatal Quarter Horses. (5/1979)

Three Quarter Horses, a stillborn filly (horse No. 1), a female fetus aborted at approximately 6 months of gestation (horse No. 2), and a 1-month-old colt that had been weak at birth (horse No. 3), had myopathy characterized histologically by large spherical or ovoid inclusions in skeletal and cardiac myofibers. Smaller inclusions were also found in brain and spinal cord and in some cells of all other tissues examined. These inclusions were basophilic, red-purple after staining with periodic acid-Schiff (both before and after digestion with diastase), and moderately dark blue after staining with toluidine blue. The inclusions did not react when stained with Congo red. Staining with iodine ranged from pale blue to black. Their ultrastructural appearance varied from amorphous to somewhat filamentous. On the basis of staining characteristics and diastase resistance, we concluded that these inclusions contained amylopectin. A distinctly different kind of inclusion material was also present in skeletal muscle and tongue of horse Nos. 1 and 3. These inclusions were crystalline with a sharply defined ultrastructural periodicity. The crystals were eosinophilic and very dark blue when stained with toluidine blue but did not stain with iodine. Crystals sometimes occurred freely within the myofibers but more often were encased by deposits of amylopectin. This combination of histologic and ultrastructural features characterizes a previously unreported storage disease in fetal and neonatal Quarter Horses, with findings similar to those of glycogen storage disease type IV. We speculate that a severe inherited loss of glycogen brancher enzyme activity may be responsible for these findings. The relation of amylopectinosis to the death of the foals is unknown.  (+info)

Whence the arthrogrypotics? (6/1979)

During the course of a nation-wide survey of patients with bone and joint deformities, twenty-six individuals with arthrogryposis multiplex congenita, in the narrow and precise sense of the term, were investigated. No patient was more than twenty-four years of age. However, on a basis of the figures of population, it can be estimated that 21-0 +/- 6-5 older affected individuals should have been encountered. Furthermore, there was a relative excess of younger children. The series was reasonably unbiased, and as arthrogryposis is non-lethal the deficiency of affected adults is an anomalous finding. It is tentatively suggested that arthrogryposis might result from the intra-uterine influence of an unknown environmental agent which has been present in South Africa for only a limited period of time. Detection of this factor could be an important step in the prevention of the disease.  (+info)

Neurological morbidity after fetal supraventricular tachyarrhythmia. (7/1979)

BACKGROUND: Fetal tachyarrhythmia is a well-documented entity which, in the absence of pharmacological intervention, may lead to congestive heart failure, fetal hydrops and eventually fetal demise. The success rate of the implemented treatment is generally measured by survival and achievement of control of the arrhythmia. We report on the occurrence of associated cerebral damage in three patients with fetal tachycardia. METHODS: We describe three patients with a history of fetal supraventricular tachyarrhythmia who developed cerebral complications in utero. RESULTS: Two patients had cerebral hypoxic-ischemic lesions and one had hemorrhagic lesions present at birth. They had developed severe congestive heart failure and fetal hydrops secondary to fetal tachyarrhythmia, and there were no other obvious causes for the cerebral pathology. Two of these patients were referred to us antenatally. Therapy was instituted and resulted in control of the tachycardia and resolution of hydrops. The third patient was referred to our clinic shortly after birth because of severe circulatory problems secondary to fetal tachyarrhythmia. CONCLUSION: From these observations, we believe that a fetus with tachyarrhythmia and subsequent hydrops is at increased risk for the development of cerebral complications, due to the circulatory disturbances and sudden changes in heart rate which may lead to fluctuations in cerebral perfusion. This would imply that it is of the utmost importance to aim at immediate and complete control of the heart rate in the treatment of fetal tachyarrhythmia.  (+info)

Trisomy 10: first-trimester features on ultrasound, fetoscopy and postmortem of a case associated with increased nuchal translucency. (8/1979)

We report a case of the prenatal diagnosis of trisomy 10 in a fetus presenting with an increased nuchal translucency thickness (5 mm) on a routine first-trimester anomaly scan at 12 weeks' gestation. Multiple abnormalities were diagnosed by ultrasound and fetoscopy. Karyotyping on chorionic villus sampling led to the diagnosis of homogeneous trisomy 10 which was confirmed by in situ hybridization on fetal tissue samples. Postmortem examination confirmed major anatomical malformations, including facial cleft, arthrogryposis of the upper and lower limbs and bilateral diaphragmatic hernia, and also revealed hypoplastic lungs, right renal agenesis and a complex cardiac malformation. Trisomy 10 is an uncommon chromosomal abnormality that is likely to be associated with increased fetal nuchal translucency. This case also emphasizes the value of a detailed anomaly scan in high-risk patients in the first trimester of pregnancy.  (+info)

The pandemic of COVID-19 is seriously challenging the medical organization in many parts of the world. This novel corona virus SARS-CoV-2 has a specific tropism for the low respiratory airways, but causes severe pneumonia in a low percentage of patients. However, the rapid spread of the infection during this pandemic is causing the need to hospitalize a high number of patients. Pneumonia in COVID-19 has peculiar features and can be studied by lung ultrasound in the early approach to suspected patients. The sonographic signs are non-specific when considered alone, but observation of some aspects of vertical artifacts can enhance the diagnostic power of the ultrasound examination. Also, the combination of sonographic signs in patterns and their correlation with blood exams in different phenotypes of the disease may allow for a reliable characterization and be of help in triaging and admitting patients.
The first journal to focus on the fetus as a patient, Fetal Diagnosis and Therapy provides a wide range of biomedical specialists with a single source of reports encompassing the common discipline of
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your digital file in Fetal Diagnosis and Therapy format for free.
I turned up for my second, supposed to be last, ultrasound in my first pregnancy with some apprehension. Here in the UK, its often called the big scan, done at 20 weeks to look for anomalies in the baby. You dont normally see your baby again until theyre born unless theres a problem. There was a problem. The sonographer couldnt find a stomach. My husband realized this was a problem. I didnt. I had been given a leaflet before the scan that said if the baby hadnt swallowed any amniotic fluid recently then the stomach might not be visible and they will call you back for a repeat scan. So I assumed that was all it was. We werent able to find out the gender in our hospital but wed seen quite clearly the baby had male anatomy and we had a quick chat about the fact we were having a boy. Then my husband went quiet. I thought he was disappointed and assumed he had wanted a girl. Actually, he had picked up the fact the scan had been abandoned by the technician (I thought theyd just decided ...
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In pregnancy, infections are a common complication-but women may not have obvious symptoms, or they may show different symptoms of an infection.
TY - JOUR. T1 - Immunohistochemistry in non-immune hydrops fetalis. T2 - A single center experience in 79 fetuses. AU - Bellini, Carlo. AU - Fulcheri, Ezio. AU - Rutigliani, Mariangela. AU - Calevo, Maria Grazia. AU - Boccardo, Francesco. AU - Campisi, Corradino. AU - Bonioli, Eugenio. AU - Bellini, Tommaso. AU - Hennekam, Raoul C M. PY - 2010/5. Y1 - 2010/5. N2 - The objective of our study was to evaluate the usefulness of immunohistochemical (IHC) staining techniques in the etiological diagnosis of non-immune hydrops fetalis (NIHF). The records of all 1,098 autopsies performed between January 1987 and May 2008, by the Division of Fetal Pathology of the University of Genoa, were reviewed and all 79 fetuses diagnosed with NIHF were re-evaluated. Additional IHC staining using antibodies that specifically stain blood and lymph vessels (CD31, CD34, smooth muscle actin antibody, D2-40) were performed. Results were compared to results from the literature. Our results showed that in 67/79 cases, ...
Objectives Deviation of the intra-abdominal umbilical vein has been described as a marker of congenital diaphragmatic hernia (CDH) and has been shown to help identify liver herniation into the fetal chest. The purpose of this study was to quantify th
The Doernbecher Fetal Therapy Program provides expert prenatal diagnosis and treatments for congenital birth defects. Learn about our fetal therapy services.
An article on cordocentesis: what fetal blood sampling involves, when its performed and what the risks and benefits are. Also includes information on the costs of cordocentesis.
Citation Machine™ helps students and professionals properly credit the information that they use. Cite your book in Fetal Diagnosis and Therapy format for free.
Cordocentesis, also sometimes called Percutaneous Umbilical Cord Blood Sampling, is a test that examines blood from the fetus to detect fetal abnormalities.
Vanlierde, M. ; Demuylder, X. ; Thomas, Karl. [The Antenatal Diagnosis of Central Nervous-system Abnormalities]. In: Louvain médical, Vol. 100, no. 9, p. 633-647 (1981 ...
Learn more about fetal therapy and fetal surgery general topics in this list of publications and research by the staff of the Center for Fetal Diagnosis and Treatment.
International Society for Prenatal Diagnosis (ISPD) - Advancing the medical practice and science of prenatal diagnosis and therapy by bringing together a global multidisciplinary group of medical and scientific professionals
Free, official coding info for 2018 ICD-10-CM Z03.7 - includes detailed rules, notes, synonyms, ICD-9-CM conversion, index and annotation crosswalks, DRG grouping and more.
Looking for online definition of fetal echogenic bowel in the Medical Dictionary? fetal echogenic bowel explanation free. What is fetal echogenic bowel? Meaning of fetal echogenic bowel medical term. What does fetal echogenic bowel mean?
Fetal Tachycardia (FT) is described as increase in baseline fetal heart rate (FHR) above 160bpm. Mild fetal tachycardia is described as 161-180bpm and severe tachycardia is defined as greater than 180bpm for at least three minutes. The fetal tachycardia causes include maternal fever, dehydration or anxiety, maternal ketosis, medications like anticholinergic medications, sympathomimetic medications like terbutaline, fetal movement, preterm fetus, maternal thyrotoxicosis and maternal anaemia1. Fetal tachycardia is considered significant (any range ,160-180bpm) in the presence of maternal pyrexia as Chorioamnionitis is suspected. Fetal arrhythmia or congenital defect is associated with FHR more than 200 bpm. Baseline FHR tachycardia represents an increase in sympathetic and or a decrease in parasympathetic autonomic nervous system tone1.. Complicated fetal tachycardia in the presence of decelerations or maternal fever qualify the decision for delivering the baby in view of fetal distress and ...
Looking for online definition of fetal bradycardia in the Medical Dictionary? fetal bradycardia explanation free. What is fetal bradycardia? Meaning of fetal bradycardia medical term. What does fetal bradycardia mean?
PubMedID: 26614154 | Anesthesia for EXIT procedure (ex utero intrapartum treatment) in congenital cervical malformation - a challenge to the anesthesiologist. | Brazilian journal of anesthesiology (Elsevier) | 11/28/2015
TY - JOUR. T1 - Management of non-immune hydrops. T2 - 8 Years experience. AU - Anandakumar, C.. AU - Biswas, A.. AU - Wong, Y. C.. AU - China, D.. AU - Annapoorna, V.. AU - Arulkumaran, S.. AU - Ratnam, S.. PY - 1996/9. Y1 - 1996/9. N2 - During a period of 8 years (1985-92), 100 fetuses were diagnosed to have non-immune hydrops on the basis of ultrasonographic findings and absence of rhesus isoimmunization. Both the mother and the fetus were thoroughly evaluated by a set protocol that included a detailed fetal abnormality scan with echocardiography and fetal blood sampling. A cause for non-immune hydrops could be identified in 81% of the fetuses. Cardiovascular abnormalities (23%) and α1-thalassemia (22%) were almost equally common etiological factors in the South-East Asian population under investigation. A chromosomal abnormality was detected in 10% of the fetuses with non-immune hydrops. Twenty-six fetuses were found to be suitable for in utero therapy. In utero therapy included one or ...
2006 all cases of fetal SUA, from Security Forces Hospital, Riyadh, Kingdom of Saudi Arabia, in a routine obstetric population were studied. Targeted sonograms and perinatal follow up were obtained. Sixteen thousand women completed the study, 162 cases of SUA were diagnosed on the basis of prenatal sonograms, however 169 cases [53 non isolated SUA and 116 isolated SUA] confirmed postnatafly. The sensitivity, specificity, positive predictive value and negative predictive value of prenatal ultrasonographic diagnosis of SUA were 90.5%, 99.9%, 94.4% and 99.8% respectively. Aneuploidy and cardiac abnormalities were present in 8 out of the 53 [15%] and 17/53 [32%] In none isolated SUA respectively. fetuses with SUA should get further evaluation at centers that handle high-risk cases and parent should strongly counseled for fetal echocardiogram and fetal karyotyping In case of none isolated SUA ...
TY - JOUR. T1 - Prenatal detection of neuroblastoma by fetal ultrasonography. AU - Saylors, Robert L.. AU - Cohn, Susan L.. AU - Morgan, Elaine R. AU - Brodeur, Garrett M.. PY - 1994/1/1. Y1 - 1994/1/1. N2 - Purpose We report three cases of neuroblastoma diagnosed by prenatal ultrasound examination and examine the biologic features of tumors diagnosed prenatally.: Patients and Methods Neuroblastoma is the most common tumor detected in the newborn period. Thus, some of these tumors develop prenatally and should be detectable by maternal ultrasound. Here we report three cases in which a neuroblastoma was suspected on prenatal ultrasonography. In addition, we review selected features of 17 additional cases reported in the literature.: Results and Conclusions These data indicate that, although the majority of patients have favorable clinical and biological features and do well, some patients do not, and the DNA index may be the most important predictor of outcome.. AB - Purpose We report three cases ...
Interstitial deletion of chromosome 1 (1p21.1p12) in an infant with congenital diaphragmatic hernia, hydrops fetalis, and interrupted aortic arch ...
Fetal Care Center doctors partner with pediatric urologists and kidney experts to provide care for babies with fetal hydronephrosis, or kidney swelling.
Congenital diaphragmatic hernia (CDH) is associated high mortality and morbidity, mainly in those cases with severe forms where there are extremely reduced lung volumes, liver herniation and decreased abnormal pulmonary vascularization. Fetal endoscopic tracheal occlusion performed between 26 and 30 weeks (standard FETO) has been shown to increase fetal pulmonary size and vascularity, and to improve infant survival in isolated severe CDH. Fetal pulmonary response followed FETO can be used to predict outcome and is dependent on the size of the fetal lung prior to the procedure.. We hypothesize that performing an earlier FETO, between 22-24 weeks, fetuses with severe form of CDH will have a better fetal pulmonary response and higher chance of surviving. ...
Bipolar cord cautery: a percutaneous ultrasound-guided technique with endoscopic evaluation capability that introduces a 3.0-mm bipolar cautery device through a 4.0-mm trocar sheath, and with ultrasound guidance, the umbilical cord is grasped between the bipolar devices jaws and 60 to 100 W of power is applied in 2 to 3 sites to obtain cord/vascular occlusion with absence of umbilical cord blood flow documented by Doppler evaluation; endoscopic visualization of the cord cautery sites can be undertaken as well, but complete occlusion can not be confirmed visually. ...
Additional information regarding the prenatal diagnosis, prognosis, management and post-natal management of common fetal anomalies can be obtained within individual Not a Textbook (NaT) chapters, accessible for purchase via the APSA ExPERT platform as well as in the APSA handbook: Fetal Diagnosis and Therapy, A Reference Handbook for Pediatric Surgeons which is available for download for APSA members ...
Over the years there has been steadfast increase in the quantity of patients with a prenatally detected structural congenital heart disease. Despite efforts to achieve the contrary, some of these pregnancies will end in intra-uterine death. In these patients the sole advantage of the prenatal diagnosis is the facilitation of ... read more thorough parental counseling concerning future pregnancies; additionally it might help parents better to cope with the loss of their child. The primary goal of prenatal detection of cardiac defects, however, is the enabling of better care in the immediate postnatal period and the most convincing justification for the efforts taken, would be to demonstrate that prenatally diagnosed patients have a better chance on a good outcome as a result of early initiation of therapy. This thesis shows that prenatal diagnosis of heart disease, both morphological and functional, may influence management of pregnancy and outcome for affected fetuses. It is the most important ...
ICD-10-PCS code BY33ZZZ for Magnetic Resonance Imaging (MRI) of Fetal Abdomen is a medical classification as listed by CMS under Fetus and Obstetrical range.
Hydrops fetalis is a serious condition of the fetus or newborn. It is a condition where abnormal amounts of fluid build up in two or more body areas causing swelling. Severe swelling can interfere with how the body organs work and often results in death of the infant shortly before or after delivery.. ...
During a routine prenatal ultrasound, your doctor may be able to detect abnormalities with how the diaphragm is developing. An MRI may then be used to
Prenatal ultrasound is common but is it safe? Learn the hidden dangers. Ultrasound is implicated in interference to neural pathways, DNA mutation & brain damage. The damage is cumulative. Is ultrasound connected to the rise of autism?
Publications and research about prenatal diagnosis and treatment from the staff at the Center for Fetal Diagnosis and Treatment at CHOP.
The leamer should be able to improve technical perfonmance of echocardiograms in congenital heart disease. They should be able to further their understanding of complex physiology and the appropriate questions to answer with the study. In addition, emphasis is placed on medical andlor surgical management as well as further studies (cardiac catheterization, cardiac magnetic resonance imaging or computed tomography scan) that may be needed. Information to be obtained on followup echocardiograms will also be reviewed.. These sessions are designed to improve the technical performance and interpretation of echocardiograms in complex congenital and acquired heart disease. Case studies are presented, followed by discussion of new noninvasive methods of evaluation and medical and/or surgical management options. All attendees are invited to participate in the discussion. ...
Parallel construction may also present a series or make comparisons. In these usages, the elements of the series or of the comparison should be parallel structures, eg, nouns with nouns, prepositional phrases with prepositional phrases. Note: Avoid the use of nor when the first negative is expressed by not or no.Fetuses with congenital diaphragmatic hernia who were stillborn would not have been included in this study or [not nor] in many previously published studies. But: Fetuses with congenital diaphragmatic hernia who were stillborn would not have been included in this study, nor would they have been included in other
Parallel construction may also present a series or make comparisons. In these usages, the elements of the series or of the comparison should be parallel structures, eg, nouns with nouns, prepositional phrases with prepositional phrases. Note: Avoid the use of nor when the first negative is expressed by not or no.Fetuses with congenital diaphragmatic hernia who were stillborn would not have been included in this study or [not nor] in many previously published studies. But: Fetuses with congenital diaphragmatic hernia who were stillborn would not have been included in this study, nor would they have been included in other
O36.4XX3 is a billable code used to specify a medical diagnosis of maternal care for intrauterine death, fetus 3. Code valid for the year 2020
TY - JOUR. T1 - Prenatal diagnosis and management of endocrine and metabolic disorders.. AU - Charrow, J.. PY - 1985/12/1. Y1 - 1985/12/1. UR - UR - M3 - Article. C2 - 3914095. AN - SCOPUS:0022292206. VL - 7. SP - 131. EP - 174. JO - Special topics in endocrinology and metabolism. JF - Special topics in endocrinology and metabolism. SN - 0193-0982. ER - ...
Some psychoanalytic researches are reviewed here to give an overview of how ideas on prenatal life and psychoanalytic ideas on ego-formation got tentatively together during the last century and the first years of the new century. There is a large bow to Ferenczi who published his long paper Thalassa in 1924 after about ten years of thoughts on it that were shared by Maiello, Hidas and Raffai, and Wilheim. Certainly this bow is incomplete. However, we can see how prenatal life becomes more relevant in psychoanalytic research, too. ...
In commemoration of the Lenten Season, Id like to share one of my Lenten experiences. This happened last year though. I received a call of referral to attend to the delivery of a baby who was initially diagnosed as a case of hydrops fetalis (baby is swollen all over his body). Hydrops fetalis (not the…
This was a 28-year-old lady, gravida 2, para 1, live 1 and nil abortion and non-consanguinous marriage. Her BPD ( 6.5 % tile) and HC ( 7 % tile) were less than 10 % tile. Mild ventriculomegaly was seen. ( 11.34 % tile). A careful look at the 3rd ventricle shows a solid mass. Some…
Ultrasound A routine prenatal ultrasound is offered to all pregnant women around 18 weeks of pregnancy. The purpose is to measure the length of the pregnancy, find out if there are twins or other multiples, look for abnormalities and to locate the placenta. The exam is voluntary.
The 20 week ultrasound scan checks for major physical abnormalities in your baby as well an opportunity to find out the sex (gender) of the baby.
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Your body is made up of millions of tiny cells. Different types of cells form the different structures of the body - skin, muscles, nerves, organs, etc....
Lima, M.; Kay, T.; Vasconcelos, J.; Mota-Vieira, L.; Gonzalez, C.; Peixoto, A.; Abade, A.; MacLeod, P.; Graca, R.; Santos, J. (2001-07) ...
TY - JOUR. T1 - Standardization of sonographic lung-to-head ratio measurements in isolated congenital diaphragmatic hernia. T2 - Impact on the reproducibility and efficacy to predict outcomes. AU - Britto, Ingrid Schwach Werneck. AU - Sananes, Nicolas. AU - Olutoye, Oluyinka O.. AU - Cass, Darrell L.. AU - Sangi-Haghpeykar, Haleh. AU - Lee, Timothy C.. AU - Cassady, Christopher I.. AU - Mehollin-Ray, Amy. AU - Welty, Stephen. AU - Fernandes, Caraciolo. AU - Belfort, Michael A.. AU - Lee, Wesley. AU - Ruano, Rodrigo. PY - 2015/1/1. Y1 - 2015/1/1. N2 - Objectives - The purpose of this study was to evaluate the impact of standardization of the lung-to-head ratio measurements in isolated congenital diaphragmatic hernia on prediction of neonatal outcomes and reproducibility. Methods - We conducted a retrospective cohort study of 77 cases of isolated congenital diaphragmatic hernia managed in a single center between 2004 and 2012. We compared lung-to-head ratio measurements that were performed ...
PubMedID: 23151899 | Periventricular nodular heterotopia on prenatal ultrasound and magnetic resonance imaging. | Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology | 8/1/2013
Fetal double aortic arch (DAA) malformation is a rare congenital heart disease with few reported cases in the literature. We aimed to investigate the characteristics of prenatal ultrasound and postnatal computed tomography angiography (CTA) of DAA and to describe the associated anomalies and clinical outcomes to improve prenatal diagnosis and assist in perinatal management. The obstetric ultrasound imaging databases of seven tertiary referral centers were reviewed retrospectively to identify fetuses with a prenatal diagnosis of DAA between January 2013 and December 2018. Ultrasonographic findings, associated anomalies, genetic abnormalities, postnatal CTA images, and long-term postnatal outcomes were evaluated. A total of 36 cases out of 40 prenatally diagnosed DAA fetuses were confirmed by postnatal diagnosis (fetal autopsy, CTA, and surgery). In this cohort of 36 confirmed cases, 24 (67%) were isolated anomalies, while 12 (33%) were associated with intracardiac or extracardiac anomalies, and 2 (6%)
Choroid plexus cyst. Ultrasound scan of a foetus brain with a choroid plexus cyst (CPC). The choroid plexus is a layer of cells and blood vessels at the centre of the foetal brain. It produces a fluid, called cerebrospinal fluid, that flows around the brain and provides a protective cushion for it against impacts. CPCs in foetuses are temporary bubbles of trapped fluid that are usually gone by the 32nd week of pregnancy. They are classed as markers for underlying chromosome abnormalities in the foetus. Ultrasound scanning is a diagnostic technique that sends high-frequency sound waves into the body via a transducer. The returning echoes are recorded and used to build an image of an internal structure. - Stock Image M130/1007
BOTTO, Hugo A. et al. Ex utero intrapartum treatment - Management of neonatal congenital high airway obstruction syndrome: Case report. Arch. argent. pediatr. [online]. 2010, vol.108, n.4, pp.e92-e95. ISSN 0325-0075.. In recent years, the ex utero intrapartum treatment (EXIT), that involves extrauterine fetal intubation prior to delivery, has become relevant for the reduction in morbidity and mortality of neonates affected by congenital high airway obstruction syndrome (CHAOS). Clinical case. We report the case of the mother of an unborn child at pregnancy week 22, who was diagnosed a congenital pulmonary malformation that precluded intrapartum fetal circulatory deficit and resulted in the conduction of an EXIT technique, with the aim of ensuring fetal blood gas exchange at the time of delivery. Conclusions. A timely practice of the EXIT technique resulted, by monitoring both maternal and fetal factors that might affect fetoplacental circulation, in the birth of a child whose immediate and ...
Text of S. 3396 (112th): Congenital Diaphragmatic Hernia Research Act ... as of Jul 18, 2012 (Introduced version). S. 3396 (112th): Congenital Diaphragmatic Hernia Research Act of 2012
Eventbrite - CHERUBS - The Association of Congenital Diaphragmatic Hernia Research, Awareness & Support presents 2013 Day of Congenital Diaphragmatic Hernia Awareness Parade of Cherubs - Seattle, WA - Friday, April 19, 2013 at Fisher Pavilion, Seattle, WA. Find event and ticket information.
Want to support the cause? Send a proclamation request to your governor and mayor to proclaim April 2017 as Congenital Diaphragmatic Hernia Awareness Month! Click here to download a blank letter. Please send a copy of the proclamation to the awareness committee at [email protected] so we can share ...
Want to support the cause? Send a proclamation request to your governor and mayor to proclaim April 2017 as Congenital Diaphragmatic Hernia Awareness Month! Click here to download a blank letter. Please send a copy of the proclamation to the awareness committee at [email protected] so we can share ...
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Abuhamad, A, Chaoui, R. A Practical Guide to Fetal Echocardiography: Normal and Abnormal Hearts. Lippincott Williams and Wilkins. 2010. (This textbook reviews the practical aspects of fetal echocardiography as well as the interpretation of findings in normal and abnormal hearts. The final chapter on Fetal Arrhythmias includes a section on diagnosis and management of fetal bradyarrhythmias.). Askanase, AD, Friedman, DM, Copel, J. Spectrum and progression of conduction abnormalities in infants born to mothers with anti-SSA/Ro-SSB/La antibodies. Lupus.. vol. 11. 2002. pp. 145-51. (The authors examined records from children enrolled in the Research Registry for Neonatal Lupus and described the various conduction abnormalities in infants born to mothers with anti-Ro (SSA) and/or anti-La (SSB) antibodies. They described findings on fetal echocardiogram and postnatal electrocardiogram. They noted that resolution of incomplete AV block was variable and that progression of incomplete block could ...
Fetal bradycardia refers to an abnormally low fetal heart rate, a potentially ominous finding. A sustained first trimester heart rate below 100 beats per minute (bpm) is generally considered bradycardic. The average fetal heart rate changes durin...
0062]Optionally, the system 100 includes a form generator 107 which generates a form for each fetal scan plane in the group. Each form allows the operator to submit his diagnosis pertaining to the fetal scan plane. Optionally the form is a graphical user interface which is presented to the operator in a client terminal, such a personal computer, a PDA, a Smartphone, a thin client, a laptop and the like. FIG. 3 is an exemplary form which is presented to allow the operator, to input data pertaining to the presence and/or absence of one or more fetal abnormalities, such as structural malformations, in relation to an ultrasonographic image depicting a selected scan plane. The operator may mark the fetal abnormalities and the level of certainty thereof. The form generator 107 allows monitoring the inputs provided by the operator. Optionally, a set of fetal scan planes are defined per examination. Each fetal scan plane is associated with a checklist of one or more diagnosis events. The form generator ...
The importance of expert pregnancy monitoring during with a fetus diagnosed with Congenital Diaphragmatic Hernia (CDH). Presented by Linda Hopkins, MD, and t...
A congenital diaphragmatic hernia (CDH) is most commonly repaired through the abdomen using an incision just below the rib cage. Depending on the size
Congenital diaphragmatic hernia (CDH) is not as well known as muscular dystrophy and cystic fibrosis, but like them it is a life-threatening birth defect, and is just as common. Occurring in one in 3,000 births, CDH causes the guts and liver to protrude through a defective diaphragm and into the chest cavity, where they interfere with the lungs.
Dive into the research topics of Neurodevelopmental outcome in congenital diaphragmatic hernia survivors: Role of ventilatory time. Together they form a unique fingerprint. ...
Congenital diaphragmatic hernia (CDH) is a common, phenotypically as well as genetically heterogeneous birth defect associated with high morbidity and mortality
My 14 YO daughter, Julia, whom I adopted at 6 months old, was born with a left congenital diaphragmatic hernia. She is doing extremely well now, with
Prenatal diagnostic test is a non-invasive test for detecting the most common chromosomal abnormalities in women. Detect for example Downs Syndrome
One of the most widely discussed topics in the postnatal management of ANH is the initiation of continuous antibiotic prophylaxis (CAP). One study found that infants with ANH were nearly 12 times more likely to have pyelonephritis-related hospitalizations in the first year of life.16 The risks versus benefits of long-term antibiotics may not always be clear, but there are several factors that pharmacists should consider when evaluating the need for CAP.. The necessity of CAP depends on the presentation of several risk factors. Guidelines by the American Urological Association do not recommend CAP in patients with SFU grades I and II.17 One study found that patients with SFU grade I or II had resolution rates of 96.7% and 98.6%, respectively, and only 0.7% of patients experienced febrile UTI.3 Other studies have also demonstrated a low likelihood of UTI in mild ANH even in the presence of VUR or UPJO.18,19 Another study revealed that patients with low-grade hydronephrosis receiving CAP had ...
Introduction: Among congenital dysplasias the anomalies of kidney and urogenital tract are among the most frequent encountered. Their rate in prenatally made diagnoses is about 50 %. Modern prenatal diagnostic facilities have changed the therapeutic access to these anomalies in the last decade. After a phase of overtreatment in the beginning, nowadays new insights in the natural course of these dysplasias and the results of long-term follow-up studies resulted in a more differentiated apporach. Questions and methods: In this retro- and prospective study we looked for the the influence of prenatal diagnostics on the postnatal course and management. The question was to examine the relationship between the prenatal ultrasound results, the suggested prenatal diagnosis and then the defintive postnatal disease. Of interest was the prognostic impact of typical prenatal sonographic imaging on the postnatal course of the baby. Because of its frequency we focused on anomalies of the kidney and urogenital ...
Pregnant with hydronephrosis - 33 wk pregnant, Dx hydronephrosis of 1kidney, was 10 last month now 12. Wants weekly ultrasound and 2xwk fetal mon. Excessive? Here are some... Why dont you bring this concern to your obs-doc? Clinically, at this stage of pregnancy, it is practically unnecessary to frequently repeat ultrasound imaging since there would be nothing that needs or could be done. At most, repeat it once before childbirth is taking place so to get idea if fetal hydronephrosis may interfere natural delivery; if possible, C-section may be required. So, ask doc..
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Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies. ...
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Congenital diaphragmatic hernia can be detected before birth with prenatal ultrasound scan. The presence of a hole in the diaphragm results in breathing difficulties due to incomplete growth of lungs.
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My doctor is not that serious and m 12 weeks pregnant.i am getting anxious now i want to see if my babys fyn as i am nt feeling much of pregnancy symptoms like
ultrasound screening equipments_Obstetric ultrasound -- a comprehensive guide to Comprehensive guide to Obstetric/ prenatal ultrasound. Covers all aspects of sonography in pregnancy and the fetus. Ultrasound - GE HealthcareGE
The aim of this study was to evaluate the detection of fetal structural abnormalities by the 11-14 week scan. 2853 pregnant women were submitted to a routine ultrasound scan between the 11th and 14th week and the fetal skull, brain, spine, abdominal wall, limbs, stomach and bladder were examined. Fo …
The study aimed to analyse the clinical courses of aggressively treated neonates with cytogenetically confirmed trisomy 18, with special attention focused on the efficiency of prenatal diagnostics, associated malformations, therapeutic dilemmas and outcomes. We investigated retrospectively the data …
This week I am 27 weeks! I had to go in this week for a ultrasound because Wells had a cyst in her brain, which is gone now!! It is called a Choroid Plexus Cyst. We found out she had it during our first ultrasound at 19 weeks. I have been stressed, to say the least, for 8 weeks!! The ultrasound tech said not to worry that 1 out of 3 babies have them and they usually go away on there on. Well of course I could not stop worrying about it! I started looking/researching online and found what it could be if it didnt go away and so on. I know that is the worst thing to do but I couldnt help myself. I have been in a major funk and just so down and out. We didnt really talk about it alot because we wanted to wait and see what happened when we went back. We are so blessed that it is gone and she is perfectly healthy!! She weighs 2 lbs and 5 ozs! I feel like a different person and I just pray that everything goes good and we have a normal delivery. I am such a worry wort and will be worrying until she ...
I had my 21 week appointment today. Everything is still going great. I did have a little scare while I was at Disney World. My doctor called me personally (never a good sign) to tell me they found something on my ultrasound. They found a Choroid plexus cyst on the babys brain. Apparently it can be a marker for some chromosone issues. My doctor told me that everything else looked PERFECT on the ultrasound and she doubts anything is actually wrong, but they want to be sure. So the day after I got back I went to see a specialtist and had a level 2 ultrasound. The cyst must have shrunk (which I was told it might or even disappear) because it wasnt something the specialist gave any real concern. I was told again that they are definitly sure it is a girl. After I was told everything is fine (I was given a less than .5-1% chance that it could lead to something) I was able to enjoy the new ultrasound. The baby was yawning which I had never seen that before. She was also grabbing her toes with her ...
I know I havent really talked about it much. Probably because Im always hearing new things about this pregnancy. Its hard to keep up! Tomorrow I will be 30 weeks pregnant! I am thrilled that things are coming to an end and that our little guy will be here soon. He has definitely been harder to get here than Noah was. Warning: This could get lengthy and is really so that I can remember all the things that were abnormal with this pregnancy. Feel free to keep reading though! :) I know I shouldnt compare children or pregnancies but I feel like with Noah I went to my regular checkups and they told me everything was fine and they were never concerned. The only thing abnormal was that I was slightly anemic and had to take iron pills and I remember I had ligament pains pretty bad. Thats it. With this one, wow... I didnt have much trouble until 18 weeks. They did an ultrasound to determine the sex of the baby and they found choroid plexus cysts on his brain. I had to go to a specialist to get a ...
Fetal Echocardiography. Obstetric Ultrasound. Sonography. Advanced: What the Surgeon Can Learn From Fetal Echo (and How You Can Help) ...
Textbook solution for Human Heredity: Principles and Issues (MindTap Course… 11th Edition Michael Cummings Chapter 6 Problem 4QP. We have step-by-step solutions for your textbooks written by Bartleby experts!
"Maternal or fetal infection at or immediately following the time of delivery is an absolute contraindication to encapsulation," the APPA said in a release. "It is unsafe to encapsulate in these cases."
A drug - being studied as a preventative measure against fetal infection - would contain glycosaminoglycans, which the virus would find so irresistible that it would turn up its nose at the sugars in human cell membranes.
American Journal of Kidney Diseases. 57 (6): 945-947. doi:10.1053/j.ajkd.2011.02.381. PMID 21514023.. ... Saudi Journal of Kidney Diseases and Transplantation. 23 (2): 363-366. PMID 22382240.. ... the clinical conditions and blood clotting disorder often associated with this disease may make it impractical in a clinical ... Fetal-maternal transfusion. *Dehydration. *Perinatal asphyxia. *Anemia. *Placental hemorrhage. *Severe hemolytic disease ...
Main article: Thyroid disease in women. Hypothyroidism (also called Hashimoto's disease) is an autoimmune disease that affects ... Ethanol during pregnancy can cause fetal alcohol syndrome and fetal alcohol spectrum disorder. ... Intercurrent disease in pregnancy: A disease and condition not necessarily directly caused by the pregnancy, such as diabetes ... Fetal and placental problems[edit]. The following problems occur in the fetus or placenta, but may have serious consequences on ...
"Interstitial lung disease in newborns". Seminars in Fetal and Neonatal Medicine. 22 (4): 227-233. doi:10.1016/j.siny.2017.03. ... which might affect disease severity and may permit some to carry the disease with few or no symptoms.[3] ... Alveolar capillary dysplasia (ACD) is a rare, congenital diffuse lung disease characterized by abnormal blood vessels in the ... ACD is a rare disease. About 100 cases have been reported.[1] The first case was reported in 1981.[5] ...
The fetal origins hypothesis states that fetal undernutrition is linked with coronary heart disease later in adult life due to ... It has been documented that fetal cells such as fetal erythroblasts as well as cell-free fetal DNA are increased in the ... Fetal complications include fetal growth restriction and potential fetal or perinatal death.[15] ... McMaster-Fay RA (2008). "Pre-eclampsia: a disease of oxidative stress resulting from the catabolism of DNA (primarily fetal) to ...
Calkins, Kara; Sherin Devaskar (2011). "Fetal Origins of Adult Disease". Curr Probl Pediatr Adolesc Health Care: 158-176. ... Archives of Disease in Childhood: Fetal and Neonatal Edition. 81 (1): F10-4. doi:10.1136/fn.81.1.F10. PMC 1720965 . PMID ... ischemic heart disease Class T: prior kidney transplant An early age of onset or long-standing disease comes with greater risks ... If the woman has diabetes as an intercurrent disease in pregnancy, it can cause early labor, birth defects, and very large ...
"Archives of Disease in Childhood. Fetal and Neonatal Edition. 89 (6): F473-4. doi:10.1136/adc.2004.055095. PMC 1721777. PMID ... "Lipids in Health and Disease. 7: 38. doi:10.1186/1476-511x-7-38. PMC 2579289. PMID 18925970.. ... Hence, taurine supplementation is possibly beneficial for the prevention of these diseases. ... Neurobiology of Disease. 22 (3): 669-76. doi:10.1016/j.nbd.2006.01.012. PMID 16624563. S2CID 22502432.. ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 2006-05, 91 (3): F169-74. PMC 2672698. PMID 16223754. doi:10.1136 ...
"Fetal Alcohol Spectrum Disorders (FASDs)". Centers for Disease Control and Prevention. U.S. Department of Health and Human ... which can lead to fetal alcohol syndrome and fetal alcohol spectrum disorders.[6] Binge drinking during adolescence is ... The Centers for Disease Control and Prevention suggests increasing the cost of alcohol or the excise taxes, restricting the ... Nov 2005). "Recognition and prevention of fetal alcohol syndrome". Obstet Gynecol. 106 (5 Pt 1): 1059-64. doi:10.1097/01.AOG. ...
Micrograph showing a fetal (placental) vein thrombosis, in a case of fetal thrombotic vasculopathy. This is associated with ... Adults with cerebral palsy may have ischemic heart disease, cerebrovascular disease, cancer, and trauma more often.[44] Obesity ... Pediatric and Adult Nutrition in Chronic Diseases, Developmental Disabilities, and Hereditary Metabolic Disorders: Prevention, ... The spastic diplegia form of CP came to be known as Little's disease.[6] At around this time, a German surgeon was also working ...
Prenatal alcohol exposure can lead to fetal alcohol spectrum disorders (FASDs). The most severe form of FASD is fetal alcohol ... Centers for Disease Control and Prevention. 2007. "Tobacco Use and Pregnancy: Home". Centers for Disease Control and Prevention ... From the third month to the end of nine months is the period of fetal maturation. Intake of drugs during this period may modify ... Pregnancy and fetal development progress through various changes. The period of one week from fertilisation to implantation of ...
1992). Fetal and infant origins of adult disease. London: British Medical Journal. ISBN 0-7279-0743-3. .. ... Barker, D.J.P. (1997). "Maternal Nutrition, Fetal Nutrition, and Disease in Later Life". Nutrition, '13', pg. 807 ... The thrifty phenotype is a component of the fetal origins hypothesis. These chronic conditions include coronary heart disease, ... "The fetal origins of adult disease : No longer just a hypothesis and may be critically important in south Asia". BMJ. 322 (7283 ...
By National Institute on Drug Abuse (NIDA). "Unintentional Drug Poisoning in the United States" (PDF). Centers for Disease ... Cain, Mary A.; Bornick, Patricia; Whiteman, Valerie (2013-03-01). "The maternal, fetal, and neonatal effects of cocaine ... an autoimmune disease?". Autoimmunity Reviews. 12 (4): 496-500. doi:10.1016/j.autrev.2012.08.009. ISSN 1873-0183. PMID 22940554 ...
Barker, D J (1990-11-17). "The fetal and infant origins of adult disease". BMJ: British Medical Journal. 301 (6761): 1111. doi: ... Byrne, C. D.; Phillips, D. I. (2000-11-01). "Fetal origins of adult disease: epidemiology and mechanisms". Journal of Clinical ... respiratory diseases, cardiovascular disease, premature delivery, birth defects, low birth weight, and premature death. ... In 2017 a study revealed that PM not only affects human cells and tissues, but also impacts bacteria which cause disease in ...
Fetal and Neonatal Edition. 99 (1): F87-92. doi:10.1136/archdischild-2012-303351. PMC 4239122. PMID 23960141. Horner P, Blee K ... Many species are sexually transmitted and cause pelvic inflammatory disease. Mycoplasma refers to a genus of bacteria that lack ... Their role in neonatal disease and adverse pregnancy outcomes has been well established, and semantic classifications are ... Viscardi RM (January 2014). "Ureaplasma species: role in neonatal morbidities and outcomes". Archives of Disease in Childhood. ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 89 (6): F518-20. doi:10.1136/adc.2004.049247. PMC 1721790. PMID ... Center for Disease Control and Prevention (2013). "Strategies to Prevent Obesity and Other Chronic Diseases: The CDC Guide to ... allergic diseases, digestive diseases, obesity, develop diabetes, or childhood leukemia later in life. and may enhance ... Viral disease transmission can be prevented by expressing breast milk and subjecting it to Holder pasteurisation. Some women ...
Autoimmune disease may cause abnormalities in embryos, which in turn may lead to miscarriage. As an example, Celiac disease ... Some use the cutoff of 20 weeks of gestation, after which fetal death is known as a stillbirth. The most common symptom of a ... certain infectious diseases, and autoimmune diseases. PCOS may increase the risk of miscarriage. Two studies suggested ... Other diseases are also known to make animals susceptible to miscarriage. Spontaneous abortion occurs in pregnant prairie voles ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 72 (1): F3-7. doi:10.1136/fn.72.1.f3. PMC 2528410. PMID 7743281. ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 93 (3): F246-8. doi:10.1136/adc.2006.104448. PMID 18426926. S2CID ... Weech AA (1970). "The guilding lamp of history". American Journal of Diseases of Children. 119 (3): 199. doi:10.1001/archpedi. ... Forbes GB (December 1972). "A. Ashley Weech, MD". American Journal of Diseases of Children (1960). 124 (6): 818-9. doi:10.1001/ ... ISBN 1-4000-8214-5. Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621. Lesch ...
It is recommended only as a third line treatment in graft-versus-host-disease in adults, based on lack of efficacy and side ... Fetal and Neonatal Edition. 80 (2): F142-4, discussion F144-5. doi:10.1136/fn.80.2.F142. PMC 1720896. PMID 10325794. "The ... It is used as a second-line treatment to manage graft versus host disease and aphthous stomatitis in children and has been ... These thalidomide analogs can be used to treat different diseases, or used in a regimen to fight two conditions. Interest ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 81 (1): F10-4. doi:10.1136/fn.81.1.F10. PMC 1720965. PMID ... These range from social deprivation, genetic and metabolic diseases, immune disorders, infectious diseases, nutritional factors ... and disorders due to neurotoxicants like fetal alcohol spectrum disorder, Minamata disease caused by mercury, behavioral ... Fetal alcohol syndrome: guidelines for referral and diagnosis (PDF). CDC (July 2004). Retrieved on 2007-04-11 "Facts About TBI ...
Feldman, Gerald L; Weaver, D. D; Lovrien, E. W (1977). "The Fetal Trimethadione Syndrome". American Journal of Diseases of ... Onkal, R; Djamgoz, M. B (2009). "Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: ... Disease. 4 (6): e652. doi:10.1038/cddis.2013.174. PMC 3698542. PMID 23744352. Pei, L; Wiser, O; Slavin, A; Mu, D; Powers, S; ... Neurobiology of Disease. 73: 418-27. doi:10.1016/j.nbd.2014.09.005. PMID 25251605. S2CID 207068577. Watanabe, M; Iwashita, M; ...
34-. ISBN 978-1-62703-179-0. Carrie Bagatell; William J. Bremner (27 May 2003). Androgens in Health and Disease. Springer ... 314-. ISBN 978-1-59259-388-0. Susan Blackburn (14 April 2014). Maternal, Fetal, & Neonatal Physiology. Elsevier Health Sciences ...
Archives of Disease in Childhood. Fetal and neonatal edition. 78 (6): 548-551. doi:10.1136/adc.78.6.548. ISSN 1359-2998. PMC ... Alexander, Michael J.; Spetzler, Robert F. (October 2005). Pediatric Neurovascular Disease: Surgical, Endovascular, and Medical ... Archives of Disease in Childhood. 64 (12): 1653-1655. doi:10.1136/adc.64.12.1653. ISSN 0003-9888. PMC 1792909. PMID 2696431. ... "Prenatal Diagnosis of Unusual Fetal Pial Arteriovenous Malformation". Interv Neuroradiol. 9 (2): 163-8. doi:10.1177/ ...
Soranus uses it as the instrument in the case of an accident involving the fetal cranium. Male catheters Used in order to open ... Food was perceived to have a healing effect or a causative effect on disease, determined by its impact on the humors; as well ... Fetal and Neonatal Edition. 73 (1): F51-F52. doi:10.1136/fn.73.1.f51. ISSN 1359-2998. PMC 2528358. PMID 7552600. "Galen". ... Chlamydia is a sexually transmitted disease in which some subtypes of it can cause trachoma, which is a major source of cause ...
Diseases/disorders/syndromes should be categorized within Category:Diseases and disorders by their ICD-10 code(s). These ... Development for discussing developmental biology, i.e. embryological/fetal, associated with structure ... Diseases-The World Health Organization International Statistical Classification of Diseases and Related Health Problems (ICD 10 ... for a disease or an every-day substance as "the cause" of a disease. Newspapers and magazines may also publish articles about ...
"Archives of Disease in Childhood: Fetal and Neonatal Edition. 92 (5): F419-F420. doi:10.1136/fnn.2005.091397. PMC 2675375. PMID ... "Genetic and Rare Diseases Information Center (GARD) at the National Center for Advancing Translational Sciences. Retrieved 2017 ... The fetal urine is critical to the proper development of the lungs by aiding in the expansion of the airways - alveoli, by ... Fetal urine production begins in early gestation and comprises the majority of the amniotic fluid in the second and third ...
"Archives of Disease in Childhood: Fetal and Neonatal Edition. United Kingdom: British Medical Journal Publishing Group. 76 (1 ... for example when testing the difference between two groups who have a different disease, or testing the difference between ...
"Archives of Disease in Childhood: Fetal and Neonatal Edition. United Kingdom: British Medical Journal Publishing Group. 76 (1 ... Containing an Inquiry into the Nature, Causes, and Cure, of that Disease; Together with A Critical and Chronological View of ... Scurvy is a disease now known to be caused by a vitamin C deficiency, but in Lind's day, the concept of vitamins was unknown. ... Just after that patrol he left the Navy, wrote his MD thesis on venereal diseases and earned his MD from the University of ...
"Archives of Disease in Childhood: Fetal and Neonatal Edition. United Kingdom: British Medical Journal Publishing Group. 76 (1 ... Tropical disease[edit]. Lind's final work was published in 1768; the Essay on Diseases Incidental to Europeans in Hot Climates ... Containing an Inquiry into the Nature, Causes, and Cure, of that Disease; Together with A Critical and Chronological View of ... "Archives of Disease in Childhood. 76: F64-F65. doi:10.1136/fn.76.1.f64. PMC 1720613. PMID 9059193.. ...
Then, they could reliably identify fetal DNA, which would in turn allow them to diagnose certain fetal genetic conditions such ... because Sequenom claimed more than it taught: "any diagnosis of any disease, disorder, or condition. . . . impermissible ... detecting the presence of a paternally inherited nucleic acid of fetal origin in the sample.. ... The point of the invention is that the inventors discovered in 1996 that fetal DNA might be floating around in the mother's ...
"Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". The Journal of Nutrition. 140 (3): 437 ... Diseases of the endocrine system (ICD-10 Chapter IV: Endocrine, nutritional and metabolic diseases - Endocrine diseases, E00- ... Diabetes was one of the first diseases described.[21] The importance of insulin in the disease was determined in the 1920s.[22] ... two to four times the risk of cardiovascular disease, including ischemic heart disease and stroke; a 20-fold increase in lower ...
Rosenbloom J (1984). «Elastin: relation of protein and gene structure to disease». Lab. Invest. 51 (6): 605-23. PMID 6150137. ... Coolen NA, Schouten KC, Middelkoop E, Ulrich MM (2010). «Comparison between human fetal and adult skin». Arch. Dermatol. Res. ... 2009). «Association of genetic variants with chronic kidney disease in individuals with different lipid profiles». Int. J. Mol ... 2010). «Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous ...
This article is about a skin disease common during adolescence. For other acneiform skin diseases, see Acne (disambiguation). ... No adverse fetal events have been reported from the topical use of dapsone.[150] If retinoids are used there is a high risk of ... Disease Primers. 1: 15033. doi:10.1038/nrdp.2015.33. PMID 27227877.. *^ a b "Frequently Asked Questions: Acne" (PDF). U.S. ... Acne, also known as acne vulgaris, is a long-term skin disease that occurs when dead skin cells and oil from the skin clog hair ...
Certain conditions originating in the perinatal period / fetal disease (P, 760-779) ... List of systemic diseases with ocular manifestations. References[edit]. *^ a b c Matejcek, A; Goldman, RD (November 2013). " ... The disease incidence varies widely depending on the geographical location. The most extensive epidemiological survey on this ... "Red Book-Report of the Committee on Infectious Diseases, 29th Edition. The American Academy of Pediatrics". Retrieved 2007-07- ...
"Fetal Homicide Laws". Retrieved 2008-03-20.. *↑ Roche, Natalie E. (2004). "Therapeutic Abortion". Retrieved 2006-03- ... Those with certain diseases, and those over the age 35 also run a greater risk. Other causes for abortions can be the infection ... Certain diseases or an accidental trauma can also cause a spontaneous abortion. Putting the woman under trauma or stress to ... Fetal Medicine: Basic Science and Clinical Practice (Elsevier Health Sciences 1999), page 835. ...
listen)) is the science and practice of the diagnosis, treatment, and prevention of disease.[4][5] The word "medicine" is ... Preventive medicine is the branch of medicine concerned with preventing disease. *Community health or public health is an ... Pathology as a medical specialty is the branch of medicine that deals with the study of diseases and the morphologic, ... Medicine is the science and practice of the diagnosis, treatment, and prevention of disease. Medicine encompasses a variety of ...
Significant diseases. Cancer, bone fractures. Significant tests. screening tests, X-ray, CT, MRI, PET, bone scan, ...
"PLoS Neglected Tropical Diseases. 6 (9): e1839. doi:10.1371/journal.pntd.0001839. PMC 3459880 . PMID 23029594.. ... fetal death also occurs in nearly all those cases. Abortion decreases the risk of death to the mother.[24] Some survivors ... Descriptions of the disease date from the 1950s.[1] The virus was first described in 1969 from a case in the town of Lassa, in ... The disease is usually initially spread to people via contact with the urine or feces of an infected multimammate rat.[1] ...
Altering the progression of left sided heart disease". Progress in Pediatric Cardiology. 22: 71-78. doi:10.1016/j.ppedcard. ... In fetal life, this is condition is manageable because the ductus arteriosus acts as a bypass, and supports the delivery of ... In this procedure, fetal positioning is crucial. It is important that the left chest is located anteriorly, and that there are ... Fetal aortic stenosis is a disorder that occurs when the fetus' aortic valve does not fully open during development. The aortic ...
... and systemic diseases that occur as a result of kidney disease, such as renal osteodystrophy and hypertension. A physician who ... the study of normal kidney function and kidney disease, the preservation of kidney health, and the treatment of kidney disease ... Many diseases affecting the kidney are systemic disorders not limited to the organ itself, and may require special treatment. ... Chronic kidney disease is typically managed with treatment of causative conditions (such as diabetes), avoidance of substances ...
Disease Markers". 2018, s. 7698193, 2018. DOI: 10.1155/2018/7698193. PMID: 29581795. PMCID: PMC5822871. ... Exposure to Fetal Testosterone, Physical Aggression, and Violent Behavior: A Meta-Analysis of the 2D:4D Digit Ratio. „ ... Revisiting the Criminological Consequences of Exposure to Fetal Testosterone: A Meta‐Analysis of the 2D:4D Digit Ratio. „ ...
"Polycystic Kidney Disease". Retrieved 2016-07-08.. *^ a b c Tave D (1999). Inbreeding and brood stock ... Khlat M (December 1989). "Inbreeding effects on fetal growth in Beirut, Lebanon". American Journal of Physical Anthropology. 80 ... "Polycystic kidney disease , International Cat Care". Retrieved 2016-07-08.. ... There may also be other deleterious effects besides those caused by recessive diseases. Thus, similar immune systems may be ...
The emphasis now is on explaining to the general public surgical disease, how it was treated over the centuries and how it is ... There are casts showing foetal development and the anatomy and pathology of the intestine. ... In the 19th and early 20th century wax and plaster casts or moulages showing abnormalities and diseases were widely used as ... Recent research projects carried out in the Museum have included studies on genetic markers for disease, facial reconstruction ...
The amniotic fluid is then recycled by fetal swallowing.[29]. Urination after injury. Occasionally, if a male's penis is ... When the sacral dorsal roots are cut in experimental animals or interrupted by diseases of the dorsal roots such as tabes ... "Amniotic Fluid: Not Just Fetal Urine Anymore". Journal of Perinatology. 25 (5): 341-348. doi:10.1038/ PMID ...
"Global Burden of Disease". W.H.O. Global Burden of Disease/en/. Retrieved 7 October 2015.. ... skin disease constituted approximately 2% of total global disease disability [36] as measured in disability adjusted life years ... "Disease List - U of U School of Medicine - , University of Utah". Retrieved 2017-02-05.. ... Dermatology is the branch of medicine dealing with the skin, nails, hair ( functions & structures ) and its diseases.[1][2] It ...
Digestive diseases and sciences, 49(5), 744-749.. 7. CHANG, F. Y., LU, C. L., CHEN, C. Y., LUO, J. C., JIUN, K. L., LEE, S. D ... Lin, C. L., Liu, T. Y., Wu, H. C., Young, S. T., Lee, M. H., & Kuo, T. S. (1996). The design of a portable fetal heart rate and ... Digestive diseases and sciences, 46(2), 242-249.. 12. Chang, F. Y., Lu, C. L., Chen, C. Y., Lee, S. D., Wu, C. W., Young, S. T ... Digestive diseases and sciences, 46(7), 1458-1465.. 13. Lin, C. L., Wu, H. C., Young, S. T., & Kuo, T. S. (2000). U.S. Patent ...
Stress and disease[edit]. The HPA axis is involved in the neurobiology of mood disorders and functional illnesses, including ... Horton TH (Jan 2005). "Fetal origins of developmental plasticity: animal models of induced life history variation". Am. J. Hum ... There is evidence shown that the HPA axis hormones can be linked to certain stress related skin diseases and skin tumors. This ... Kim JE, Cho BK, Cho DH, Park HJ (July 2013). "Expression of hypothalamic-pituitary-adrenal axis in common skin diseases: ...
Stargardt's disease. *Uveitis: is a group of 30 intraocular inflammatory diseases[44] caused by infections, systemic diseases, ... Two experimental treatments for retinal problems include a cybernetic replacement and transplant of fetal retinal cells.[71] ... GBD 2015 Disease and Injury Incidence and Prevalence, Collaborators. (8 October 2016). "Global, regional, and national ... Glaucoma is a congenital and pediatric eye disease characterized by increased pressure within the eye or intraocular pressure ( ...
Fetal malformations are most likely to occur if a pregnant woman receives a radiation dose ,500 mSv between the 10th and 40th ... The Hanford Thyroid Disease Study, an epidemiologic study of the relationship between estimated exposure doses to radioiodine ... It is also clear that fetal malformations are a greater risk if a woman is exposed to high doses of nuclear-related radiation ... Several severe adverse health effects, such as an increased incidence of cancers, thyroid diseases, CNS neoplasms, and possibly ...
Persistent fetal vasculature / Persistent hyperplastic primary vitreous. *Persistent tunica vasculosa lentis. *Familial ...
Some diseases associated with mutations in the TATA box include gastric cancer, spinocerebellar ataxia, Huntington's disease, ... The Journal of Maternal-Fetal & Neonatal Medicine. 27 (8): 844-50. doi:10.3109/14767058.2013.837879. PMID 23981182.. ... Diseases[edit]. Mutations in the TATA box region affects the binding of the TATA-binding protein (TBP) for transcription ... "The American Review of Respiratory Disease. 118 (3): 635-6. doi:10.1128/mcb.10.8.3859. PMC 360896. PMID 2196437.. ...
Hammer, edited by Stephen J. McPhee, Gary D. (2010). "Pathophysiology of Selected Genetic Diseases". Pathophysiology of disease ... European Concerted Action: DADA (Decision-making After the Diagnosis of a fetal Abnormality)". Prenatal diagnosis. 19 (9): 808- ... Global Burden of Disease Study 2013, Collaborators (22 August 2015). "Global, regional, and national incidence, prevalence, and ... "Health and disease in adults with Down syndrome". Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny ...
Polycystic ovarian disease: heritability and heterogeneity. Hum. Reprod. Update. 2001, 7 (1): 3-7. PMID 11212071. doi:10.1093/ ... Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome?. Hum. Reprod ... PCOS, coronary heart disease, stroke and the influence of obesity: a systematic review and meta-analysis. Hum. Reprod. Update. ... Imaging in Polycystic Ovary Disease. eMedicine. eMedicine. 20 April 2011 [19 November 2011].. ...
He first realised that the addition of bovine fetal calf serum (FCS) to Swiss 3T3 cells increased the polymerisation of actin ... Hall's research has had wide implications across human health and disease, particularly cancer. In addition, a generation of ...
食道(英语:Esophageal disease). *食管炎(英语:Esophagitis) *食管念珠菌感染(英语:Esophageal candidiasis) ... 生理/发育/薄膜(英语:Template:Extraembryonic and fetal membranes) ... 病理/条件源/母体传递(英语:Template:Diseases of maternal transmission), 齐名(英语:Template:Eponymous medical signs for obstetrics) ... 血管性(
This helped eradicate many contagious diseases including polio, tetanus, diphtheria and rubella, though some diseases increased ... To illustrate this, Hirschfeld describes a case where a doctor said that if the ultrasound examination revealed "some fetal ... Clinic visits are free, and the focus is on preventing disease rather than treating it.[75] Furthermore, London's The Guardian ... Following the Revolution and the subsequent United States embargo against Cuba, an increase in disease and infant mortality ...
... congenital fetal infections, drug/alcohol abuse, severe fetal anemia, cardiac disease, lung malformations, or problems with ... Hypoxic-anoxic events may affect the fetus at various stages of fetal development, during labor and delivery and in the ... Mild and moderate forms of cerebral hypoxia may be caused by various diseases that interfere with breathing and blood ... Problems after delivery can include severe prematurity, severe lung or heart disease, serious infections, trauma to the brain ...
Christian, P; Stewart, CP (2010 Mar). "Maternal micronutrient deficiency, fetal development, and the risk of chronic disease". ... Ripoll, Brian C. Leutholtz, Ignacio (2011-04-25). Exercise and disease management (2nd ). Boca Raton: CRC Press. பக். 25. ... "National Diabetes Information Clearinghouse (NDIC) (National Institute of Diabetes and Digestive and Kidney Diseases, NIH). ... நீரழிவு இரண்டாம் வகையானது மூளையசதி நோய் (Alzheimer's disease), இரத்தநாளம் சார்ந்த அறிவாற்றல் இழப்பு (vascular dementia) முதலிய ...
Fetal alcohol syndrome: cardiac birth defects in mice and prevention with folate. Am J Obstet Gynecol, 203: 75 e77-75 e15. ... José Marín-García, Signaling in the Heart, lk 179-217, Chapter 10, Signaling in Congenital Heart Disease, 2011 ... Genetic regulation of cardiogenesis and congenital heart disease. Annu Rev Pathol, 199-213. ... Congenital Heart Disease, J Am Coll Cardiol. 2002;39(6):1066-1071. doi:10.1016/S0735-1097(02)01706-0, veebiversioon (vaadatud ...
The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal ... The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal ... Assisted Reproductive Technology and Gamete/Embryo-Fetal Origins of Diseases Yi-Min Zhu, Xiao-Ling Hu, Yan-Ting Wu, Chun Feng, ... Adverse Intrauterine Environment and Gamete/Embryo-Fetal Origins of Diseases Min-Yue Dong, Fang-Fang Wang, Jie-Xue Pan, He-Feng ...
Maternal nutrition and fetal growth. In: Ward RHT, Smith SK, Donnai D eds.Early fetal growth and development. London: RCOG ... Ischaemic heart disease and low birthweight: a test of the fetal origins hypothesis from the Swedish Twin Registry.Lancet1994; ... Fetal undernutrition and coronary heart disease do not have the same distribution across the world. In China, for example, ... Present evidence suggests that this pattern of fetal growth in humans is not associated with coronary heart disease or any of ...
Fetal growth and adult disease. Eur J Clin Nutr 1998; 52(suppl 1): S72-S82. ... Fetal origins of adult disease-the hypothesis revisited BMJ 1999; 319 :245 ... The hypothesis that adult disease has fetal origins is plausible, but much supportive evidence is flawed by incomplete and ... It might be argued that the fetal origins hypothesis is more probable since fetal life is a vulnerable period of rapid ...
Fetal gene therapy for neurodegenerative disease of infants.. Massaro G1, Mattar CNZ2, Wong AMS3, Sirka E4, Buckley SMK5, ... For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal ... Gene therapy in mouse fetuses treats deadly disease. [Nature. 2018]. *Fetal gene therapy could be feasible for neuronopathic ... Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.. 10. Department of ...
Heart Association has released a scientific statement that addresses the diagnosis and treatment of fetal cardiac disease. ... That includes a detailed discussion of the fetal echocardiogram -- the main tool for evaluating fetal cardiac disease -- and ... Source Reference: Donofrio M, et al "Diagnosis and treatment of fetal cardiac disease: a scientific statement from the American ... The authors also discussed the benefits of being able to diagnose fetal cardiac disease and initiate management before delivery ...
... and chronic lung disease originate through adaptations to the intrauterine environment. These new findings suggest that… ... and experimental evidence that cardiovascular disease, Type 2 diabetes, ...
This article discusses adverse babyhood experiences (ABEs), which identify 10 categories of negative events for mothers before they conceive, and for parents and babies from conception until a childs third birthday. ABEs identify preventable and reducible non-genetic factors that increase risk for infant morbidity and mortality, chronic illness, mental health conditions, and other symptoms in a childs life; morbidity and mortality in mothers; PTSD and depression in fathers, and more. Understanding, repairing, and reversing effects of ABEs decreases risk for adverse childhood experiences (ACEs), and for poor health outcomes in parents and children.. ...
The hypothesis that certain adult diseases originate in fetal life is reasonable. However, much of the evidence is inadequately ... and understood as precursory of coronary heart disease and cerebral stroke. It is conceivable that fetal adaptation to the ... Fetal and placental size and risk of hypertension in adult life. Br Med J 1990;301:259-62. ... Geographic areas with a high recent incidence of coronary heart disease match areas showing a high rate of infant mortality in ...
Hormonal evidence related to fetal growth and later heart disease risk. Fetal growth is also affected by several hormones, ... Forsén T. Early growth and adult disease. Programming of coronary heart disease, Type 2 diabetes and hypertension by fetal and ... A key concept in the "fetal origin hypothesis" is fetal undernutrition, and its relation with adult diseases. The human ... A review of the role of fetal glucocorticoid exposure in the programming of adulthood disease. During fetal development ...
A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new ... Fetal gene therapy prevents fatal neurodegenerative disease. Fetal gene therapy prevents fatal neurodegenerative disease. 17 ... A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new ... Scientists used a viral vector to deliver genetic material into the brains of fetal mice carrying neuropathic Gaucher disease, ...
Fetal growth and coronary heart disease in south India.. Stein CE1, Fall CH, Kumaran K, Osmond C, Cox V, Barker DJ. ... The association with low maternal bodyweight is further evidence that the disease originates through fetal undernutrition. ... High rates of disease were also found in those whose mothers had a low body weight during pregnancy. The highest prevalence of ... Coronary heart disease is predicted to become the commonest cause of death in india within 15 years People from India living ...
The association with low maternal bodyweight is further evidence that the disease originates through fetal undernutrition. ... coronary heart disease is associated with small size at birth, suggesting that its pathogenesis is influenced by events in ... Fetal growth and coronary heart disease in south India Lancet. 1996 Nov 9;348(9037):1269-73. doi: 10.1016/s0140-6736(96)04547-3 ... The association with low maternal bodyweight is further evidence that the disease originates through fetal undernutrition. ...
Fetal brain grafts and Parkinsons disease. Science 07 Dec 1990:. Vol. 250, Issue 4986, pp. 1434-1435. DOI: 10.1126/science. ...
... Treatment Overview. An intrauterine transfusion provides blood to an Rh- ... Moise KJ (2009). Hemolytic disease of the fetus and newborn. In RK Creasy, R Resnik, eds., Creasy and Resniks Maternal-Fetal ... Moise KJ (2009). Hemolytic disease of the fetus and newborn. In RK Creasy, R Resnik, eds., Creasy and Resniks Maternal-Fetal ... An intrauterine fetal blood transfusion is done in the hospital. The mother may have to stay overnight after the procedure. ...
Fetal Umbilical Cord Blood (UCB) Transplant for Lysosomal Storage Diseases (IUHST-001). This study has been withdrawn prior to ... Lysosomal Storage Diseases. Inborn Errors of Metabolism. Krabbe. Infantile metachromatic leukodystrophy disease. MLD. Tay Sachs ... The fetal weight will be calculated from formula: Y (kg) = (2.9026 x 10-1) (X 2.6528). The estimated fetal weight at that ... Treatment of Early Infantile-Onset Lysosomal Storage Diseases With Fetal Umbilical Cord Blood (UCB) Transplantation. ...
Archives of Disease in Childhood - Fetal and Neonatal Edition Mar 2020, 105 (2) 116-117; DOI: 10.1136/archdischild-2019-317840 ... Archives of Disease in Childhood - Fetal and Neonatal Edition Sep 2019, 104 (5) F540; DOI: 10.1136/archdischild-2018-316667 ... Archives of Disease in Childhood - Fetal and Neonatal Edition Mar 2019, 104 (2) F225-F226; DOI: 10.1136/archdischild-2018- ... Archives of Disease in Childhood - Fetal and Neonatal Edition Jan 2019, 104 (1) F113-F114; DOI: 10.1136/archdischild-2018- ...
Archives of Disease in Childhood - Fetal and Neonatal Edition Jan 2001, 84 (1) F38-F39; DOI: 10.1136/fn.84.1.F38 ... Archives of Disease in Childhood - Fetal and Neonatal Edition Nov 2000, 83 (3) F182-F185; DOI: 10.1136/fn.83.3.F182 ... Archives of Disease in Childhood - Fetal and Neonatal Edition Jul 2000, 83 (1) F24-F27; DOI: 10.1136/fn.83.1.F24 ... Archives of Disease in Childhood - Fetal and Neonatal Edition May 2000, 82 (3) F200-F204; DOI: 10.1136/fn.82.3.F200 ...
Because fetal hemoglobin is unaffected by the genetic defect in sickle cell disease, these cell culture findings may open the ... Because this fetal hemoglobin is unaffected by the genetic defect in sickle cell disease (SCD), the cell culture findings may ... Flipping a gene switch reactivates fetal hemoglobin, may reverse sickle cell disease In lab studies, CHOP researchers reprogram ... Flipping a gene switch reactivates fetal hemoglobin, may reverse sickle cell disease. Childrens Hospital of Philadelphia ...
Coronary heart disease and type 2 diabetes may originate through two widespread biological phenomena-developmental plasticity ... Fetal origins of adult disease: strength of effects and biological basis Int J Epidemiol. 2002 Dec;31(6):1235-9. doi: 10.1093/ ... To quantify the importance of developmental processes in the genesis of CHD it is necessary to establish the impact of fetal, ... Background: Low birthweight has been consistently shown to be associated with coronary heart disease (CHD) and its biological ...
Fetal Growth and Pregnancy Complications Among Women With Heart Disease Official Title Fetal Growth and Pregnancy Complications ... Fetal growth cohort Longitudinal measurements of fetal growth, fetal circulation and maternal circulation ... Fetal Growth and Pregnancy Complications Among Women With Heart Disease (PreCor). The safety and scientific validity of this ... In addition, heart disease in pregnancy is associated to an increased rate of fetal growth restriction, premature birth, ...
Fetal Alcohol Syndrome/Fetal Alcohol Effects book recommendations from the Our Kids Website for Special Needs.. *What is Fetal ... Fetal Alcohol Syndrome Everything you need to know about Fetal Alcohol Syndrome disabilities! *Fetal Alcohol Syndrome Fact ... Seek Wellness (Fetal Alcohol). Fetal alcohol syndrome (FAS) is the name given to a group of physical and mental birth defects ... Fetal Alcohol and Drug Unit. Fetal Alcohol Syndrome research unit, headed by Dr. Ann Streissguth, University of Washington. ...
... Treatment Overview. An intrauterine transfusion provides blood to an Rh- ... Moise KJ (2009). Hemolytic disease of the fetus and newborn. In RK Creasy, R Resnik, eds., Creasy and Resniks Maternal-Fetal ... Moise KJ (2009). Hemolytic disease of the fetus and newborn. In RK Creasy, R Resnik, eds., Creasy and Resniks Maternal-Fetal ... Home , Healthy Living , Health Library , Intrauterine Fetal Blood Transfusion for Rh Disease ...
Single-cell genome analyses reveal the amount of mutations a human brain cell will collect from its fetal beginnings until ... Particular microbes in the colons of HIV patients may worsen disease progression. ... tags: fetal brain x disease/medicine x The Scientist. » fetal brain and disease/medicine ...
peripheral vascular disease. Peripheral vascular disease (PVD) is an atherosclerotic disease of the distal arterial system ... While these findings appear to cast doubt on the concept of a "fetal origin of peripheral vascular disease", this study did ... and more specifically whether this disease has its origins in part in the fetal environment. Nonetheless, there does appear to ... Osmond C, Barker DJP, Winter PD, et al. Early growth and death from cardiovascular disease in women. BMJ1993;307:1519-24. ...
Maternal-Fetal Exchange. Mitochondria, Liver / metabolism. Oxidation-Reduction. Phenotype. Pregnancy. Pregnancy Complications ... Many women who carried LCHAD-deficient fetuses developed maternal liver disease. Over the past few years, we and others have ... The likely mechanisms for the genotype-phenotype correlations in pediatric LCHAD deficiency and the fetal-maternal interaction ... made significant progress in understanding the molecular basis for this fetal-maternal interaction. Here, we review the studies ...
... An-Shine Chao,1 Angel Chao ... However, persistent severe fetal anemia and placentomegaly caused poor neonatal death and mirror syndrome in the mother. ... The Doppler peak systolic velocity in the middle cerebral artery was 0.8 m/s, indicating severe fetal anemia. Multiple ...
Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease. The safety and scientific validity of this study is ... Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease. Official Title ICMJE A Phase II Pharmacodynamic ... To describe the dose-response characteristics of vorinostat in inducing fetal hemoglobin in sickle cell disease [ Time Frame: 2 ... To describe the dose-response characteristics of vorinostat in inducing fetal hemoglobin in sickle cell disease. ...
... Researchers have ... from embryonic to fetal in early fetal life, and then fetal to adult at birth," says Ryan. ... "If we can figure out how to turn the fetal hemoglobin back on, or keep it from switching off, that would cure these diseases." ... from embryonic to fetal globin chains in early fetal life, and then to adult globin chains at birth, while wild type mice have ...
... Sickle Cell Disease (SCD) is a hereditary anemia that causes the red blood cells to change their shape from ... Sickle-cell Disease Registry of the GPOH. Sickle cell disease is one of the most common hereditary diseases. Most severe ... Hyperhemolysis Syndrome in Patients With Sickle Cell Disease.. Sickle cell disease is a genetic disease commonly affecting ... More From BioPortfolio on "Efficacy of Vorinostat to Induce Fetal Hemoglobin in Sickle Cell Disease". *Related Companies* ...
Evidence of Maternal-Fetal Transmission of Parachlamydia acanthamoebae. Emerging Infectious Diseases. 2009;15(1):120-121. doi: ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ... Waddlia chondrophila, a potential agent of human fetal death. Emerg Infect Dis. 2007;13:1239-43.PubMed ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
  • Non insulin dependent diabetes, hypertension and hyperlipidemia (Sindrome X): relation to reduced fetal growth. (
  • For inherited genetic diseases, fetal gene therapy offers the potential of prophylaxis against early, irreversible and lethal pathological change. (
  • Intrauterine programming or Barker's Theory established a basis for population and experimental research, new possible causal factors of cardiovascular disease in adult life in addition to the well known genetic and environmental factors. (
  • 1 w1 It seems likely that the large geographic variations in cardiovascular disease (CVD) morbidity and mortality, w2 even though at least partly genetic in origin, are influenced by factors acting prenatally and in early life, or by a combination of factors present throughout the life course. (
  • Gaucher disease is an irreversible, inherited genetic metabolic disorder that results from not having enough glucocerebrosidase (GCase) - an enzyme that breaks down fatty chemicals called glucocerebrosides (GBA). (
  • Scientists used a viral vector to deliver genetic material into the brains of fetal mice carrying neuropathic Gaucher disease, caused by mutations in GBA. (
  • Because this fetal hemoglobin is unaffected by the genetic defect in sickle cell disease (SCD), the cell culture findings may open the door to a new therapy for the debilitating blood disorder. (
  • Hematologists have long sought to reactivate fetal hemoglobin as a treatment for children and adults with SCD, the painful, sometimes life-threatening genetic disorder that deforms red blood cells and disrupts normal circulation. (
  • Researchers have engineered mice that model the switch from fetal to adult hemoglobin, an important step towards curing genetic blood diseases such as sickle cell anemia and beta-thalassemia. (
  • Sickle cell disease is a genetic red blood cell disorder that can result in blocking of the small blood vessels from sickle shaped red blood cells. (
  • Beckwith-Wiedemann syndrome (BWS) is a complex imprinting disorder involving fetal overgrowth and placentomegaly, and is associated with a variety of genetic and epigenetic mutations affecting the expression of imprinted genes on human chromosome 11p15.5. (
  • There has been a considerable amount of effort over the past decade to understand the genetic and molecular mechanisms responsible for the degenerative process in the hope that it will eventually be possible to interfere with this process to effect a slowing or reversal of the disease. (
  • New work by scientists at Carnegie Mellon University and Yale University has shown that it's possible to cure a genetic disorder in a fetal mouse. (
  • If we can go in and correct a genetic mutation early on, we could dramatically reduce the impact the mutation has on fetal development or even cure the condition,' said Danith Ly, professor of chemistry in Carnegie Mellon's Mellon College of Science. (
  • Differential pathophysiological pathways pertaining to genetic polymorphisms or cytogenetic aberrations are likely to create hostile environments leading either to fetal loss or the development of specific leukaemia subtypes in subsequent offspring, notably distinct associations of maternal miscarriage history confined to AML and stillbirth history confined to ALL (specifically B-ALL). (
  • Heterogeneity of HbF levels in β 0 -thalassemia/HbE disease has been reported to be associated with variations in clinical manifestations of the disease, and several genetic-modifying factors beyond the β-globin gene cluster have been identified as HbF regulators. (
  • A genome-wide association identified the common genetic variants influence disease severity in β 0 -thalassemia/hemoglobin E. Hum Genet. (
  • Genetic counseling assesses the risk of passing an inheritable disease or birth defect to your baby. (
  • Examples of cases with newborns who with sustained fetal circulation are pulmonary hypoplasia and genetic abnormalities. (
  • 10 They have shown that small size at birth or in infancy is associated with an increased propensity to adverse health outcomes in adulthood-including abnormal blood lipid values, diabetes, hypertension, and death from ischaemic heart disease. (
  • This allows specialized planning of deliveries in select cases with the goal of improved fetal and postnatal outcomes," they wrote. (
  • The expected outcome of the project is to increase the knowledge of optimal diagnosis and treatment of women with heart disease that go through pregnancy to be able to improve clinical care and the outcomes for mother and baby. (
  • As many women with congenital or acquired heart disease now go through pregnancy and childbirth, more knowledge about the risk of complications and adverse outcomes for the mother and the baby is needed to guide clinical care in this diverse patient group. (
  • Events in fetal life impact long-term health outcomes. (
  • The developmental origins of health and disease (DOHaD) theory, in which in utero or early life events can have a significant impact on adult outcomes, has become the organizing principle of fetal and perinatal biology ( 1 - 3 ). (
  • It is of particular urgency today as the Zika virus spreads and causes perinatal infection that threatens the developing fetus with serious adverse outcomes such microcephaly and other brain anomalies, placental insufficiency, and fetal growth restriction. (
  • Fetal growth restriction (FGR) is a complex disorder of human pregnancy that leads to poor health outcomes in offspring. (
  • Brief report: Risk of adverse fetal outcomes associated with immunosuppressive medications for chronic immune-mediated diseases in pregnancy. (
  • To assess the risk of adverse fetal outcomes following exposure to individual immunosuppressive drugs in pregnant women with chronic immune-mediated diseases. (
  • Yet even though preconception counseling can improve outcomes, physicians typically care for gravid women who already have significant disease. (
  • Larosa M, Del Ross T, Calligaro A, Favaro M, Zanatta E, Iaccarino L, Doria A. Clinical outcomes and predictors of maternal and fetal complications in pregnancies of patients with systemic lupus erythematosus. (
  • Original research papers cover foetal and neonatal physiology and clinical practice, genetics, perinatal epidemiology , and neurodevelopmental outcomes. (
  • There has been very little clinical evidence on pregnancy outcomes in women with melioidosis, and it is unknown if pregnant women are specifically more susceptible to B. pseudomallei or if they experience more severe disease [ 6 ]. (
  • The study reported on the nutritional status among children with sickle cell disease (SCD) in relation to disease severity and other morbidity outcomes. (
  • Undiagnosed and untreated STDs can lead to pelvic inflammatory disease (PID), ectopic pregnancy, as well as adverse fetal and neonatal outcomes. (
  • The study, published today in Nature Medicine, highlights the potential of fetal gene therapy to prevent and cure neonatal lethal neurodegenerative diseases in humans in utero. (
  • However, persistent severe fetal anemia and placentomegaly caused poor neonatal death and mirror syndrome in the mother. (
  • Menon SC, O'Leary PW, Wright GB, Rios R, MacLellan-Tobert SG, Cabalka AK (2007) Fetal and neonatal presentation of noncompacted ventricular myocardium: expanding the clinical spectrum. (
  • The fetal origins hypothesis states that fetal undernutrition in middle to late gestation, which leads to disproportionate fetal growth, programmes later coronary heart disease. (
  • The programming of blood pressure, insulin responses to glucose, cholesterol metabolism, blood coagulation, and hormonal settings are all areas of active research.The BMJ's recent editorial on the fetal origins hypothesis stated that it rests only on the "very general" proposition that fetal undernutrition causes coronary heart disease. (
  • The hypothesis states that coronary heart disease is associated with specific patterns of disproportionate fetal growth that result from fetal undernutrition in middle to late gestation. (
  • These important primary observations have led to the fetal origins hypothesis. (
  • The hypothesis that certain adult diseases originate in fetal life is reasonable. (
  • Enigma of fetal/infant-origins hypothesis. (
  • According to the Baker's Foetal Origins of Adult Health and Diseases Hypothesis, exposure of the foetus to the components of tobacco smoke results in many perturbations in the form of a lower birth weight, prematurity, worse state of neonates after birth, and higher susceptibility to contacting civilization diseases at the age of adulthood. (
  • According to the Baker's hypothesis, a lower birth weight of babies delivered by smoking mothers during the further life cycle exposes the offspring to the risk of contracting civilization diseases. (
  • These timely reviews highlight the accumulating evidence that changes in the intrauterine environment have pronounced effects on vascular function in the offspring, whether due to maternal diabetes or altered maternal nutritional status or fetal and perinatal overnutrition. (
  • A recent study of 368 pregnant mothers, led by Bettina Cuneo, MD, director of perinatal cardiology and fetal cardiac telemedicine at Children's Hospital Colorado, found that fetal congenital heart disease (CHD) was correctly identified and successfully managed according to evidence-based risk stratification. (
  • These investigations may improve the approach to optimizing antenatal as well as perinatal care aimed to protect newborns against long-term chronic diseases. (
  • Investigating fetal growth restriction and perinatal risks in appropriate for gestational age infants: using cohort and within-sibling analyses. (
  • Despite the putative intrauterine origins of childhood (0-14 years) leukaemia, it is complex to assess the impact of perinatal factors on disease onset. (
  • Compromised fetal development occurs in 3 to 8% of all pregnancies, and is associated with increased perinatal morbidity and mortality because of fetal hypoxia or iatrogenic preterm delivery [ 5 ]. (
  • Archives of Disease in Childhood focuses on all aspects of child health and disease from the perinatal period through to adolescence . (
  • In the current study, Rupon and Blobel reprogrammed gene expression to reverse the biological switch, causing cells to resume producing fetal hemoglobin, which is not affected by the SCD mutation, and produces normally shaped red blood cells. (
  • Although it was once considered to be difficult and unreliable, successful detection of this condition by way of fetal echocardiography has been well documented. (
  • Ms. Trampe is credentialed in Fetal Echocardiography by ARDMS, and has been performing fetal echocardiography exams for 18 years. (
  • She is credentialed in Fetal Echocardiography through the ARDMS. (
  • Mr. Heiser has been intimately involved with the development and implementation of fetal echocardiography protocols at Meriter Hospital, working closely with the pediatric cardiologists. (
  • Mr. Heiser is credentialed in Fetal Echocardiography by ARDMS. (
  • Her areas of interest include pediatric cardiac imaging including fetal echocardiography, preventative cardiology and resident education. (
  • Regulatory elements in DNA shift the body from producing the fetal form of hemoglobin to producing the adult form instead. (
  • In the current study, the researchers used a specialized tool, a genetically engineered zinc finger (ZF) protein, which they custom-designed to latch onto a specific DNA site carrying the code for fetal hemoglobin. (
  • The team obtained similar results in human adult red blood cells, forcing the cells to produce fetal hemoglobin. (
  • Rupon added that the approach may also prove useful in treating other diseases of hemoglobin, such as thalassemia. (
  • Percent Fetal Hemoglobin (HbF%) Induction Success Rate [ Time Frame: HbF% was measured at baseline and weekly on treatment. (
  • To determine the efficacy of vorinostat when administered orally in inducing a 4% absolute increase or a 100% increase in fetal hemoglobin levels in subjects with severe sickle cell disease who have failed prior therapy. (
  • All babies are born with hemoglobin called fetal hemoglobin (HbF). (
  • They also produced for the first time a mouse that synthesizes a distinct fetal-stage hemoglobin, which was necessary for modeling human hemoglobin disorders. (
  • These diseases manifest as misshapen hemoglobin, causing anemia, which can be severe, as well as other symptoms, which can range from minor to life-threatening. (
  • The cure would lie in causing the body to revert to use of fetal hemoglobin. (
  • If we can figure out how to turn the fetal hemoglobin back on, or keep it from switching off, that would cure these diseases. (
  • The successful engineering of a mouse with a fetal-stage hemoglobin means that humanized mouse models with mutant human genes will not die in utero. (
  • For example, Ryan and Sean C. McConnell, a doctoral student who is the paper's first author, had to deal with the fact that hemoglobin switching occurs twice in H. sapiens , from embryonic to fetal globin chains in early fetal life, and then to adult globin chains at birth, while wild type mice have a single switch from embryonic to adult chains early in fetal life. (
  • Instead of the single hemoglobin switch that occurs in wild type mice, our humanized knock-in mice now have two hemoglobin switches, just like humans, from embryonic to fetal in early fetal life, and then fetal to adult at birth," says Ryan. (
  • Hemoglobin switching is believed to have evolved to enable efficient transfer of oxygen from the mother's hemoglobin to the higher oxygen affinity fetal hemoglobin in the placenta during fetal life. (
  • Human globin knock-in mice complete fetal-to-adult hemoglobin switching in postnatal development. (
  • Factors that modify the intraerythrocytic concentration of hemoglobin S may influence the clinical expression of the disease. (
  • TY - JOUR T1 - Heterogeneity of sickle cell disease as shown by density profiles: effects of fetal hemoglobin and alpha thalassemia. (
  • Sickle cell disease (SCD) is a blood disorder caused by a point mutation on the beta globin gene resulting in the synthesis of abnormal hemoglobin. (
  • Fetal hemoglobin (HbF) reduces disease severity, but the levels vary from one individual to another. (
  • Sripichai O, Fucharoen S. Fetal hemoglobin regulation in beta-thalassemia: heterogeneity, modifiers and therapeutic approaches. (
  • Haploinsufficiency for the erythroid transcription factor KLF1 causes hereditary persistence of fetal hemoglobin. (
  • Fetal Hemoglobin Quantitative Trait Locus 6, also known as hereditary persistence of fetal hemoglobin, klf1-related , is related to hereditary persistence of fetal hemoglobin-sickle cell disease syndrome and hereditary persistence of fetal hemoglobin-beta-thalassemia syndrome . (
  • An important gene associated with Fetal Hemoglobin Quantitative Trait Locus 6 is KLF1 (Kruppel Like Factor 1). (
  • Hydroxyurea is the only medication approved by the U.S. Food and Drug Administration for sickle cell disease, and there is strong evidence to support the efficacy and the cost effectiveness of using hydroxyurea is patients with sickle cell disease by increasing fetal hemoglobin levels. (
  • It is important to clarify the relationship between patients' nutritional status/intake and fetal hemoglobin levels. (
  • Factors determining sickle cell disease severity, and the relationship between fetal hemoglobin level and patients nutritional status. (
  • All reported correlations (r 2 ) related to intake of different nutritional elements have positive significant values suggesting direct relationship, including mean fetal hemoglobin level, the number of hospitalizations and the number of days for hospitalizations in the year prior. (
  • We reported an inverse correlation between number and day of hospitalizations per year and fetal hemoglobin levels with intake of carbohydrates, lipids, iron, phosphorus, vitamins B1, and B2, but with these data we don't want to suggest a beneficial effect of low intake of these nutritional elements for these patients. (
  • We would like to highlight that these data were unexpected even for us and further studies with more patients are needed to clarify the relationship between nutritional intake and fetal hemoglobin irrespectively from HU therapy. (
  • The diagnosis of cardiac disease in the fetus is mostly made with ultrasound but newer techniques are available. (
  • Recognizing the fetus as a patient, the American Heart Association (AHA) has released a scientific statement that addresses the diagnosis and treatment of fetal cardiac disease. (
  • They pointed out that "current fetal therapeutic strategies range from maternal administration of medication with transplacental transfer to the fetus [for arrhythmia management] to ultrasound or minimally invasive fetoscopic-guided techniques to invasive open uterine fetal surgery. (
  • Fetal medicine specialists are now being asked to consider the fetus as a patient and the transition to postnatal life an important part of individualized care. (
  • Medicine may be given to the fetus to temporarily stop fetal movement. (
  • Fetal blood sampling (FBS) shows that the fetus has severe anemia. (
  • Hemolytic disease of the fetus and newborn. (
  • Excess glucocorticoid exposure of the fetus can reduce birth weight and raise blood pressure later in life in animals and humans, and babies born with low birth weight are at increased risk of diabetes and heart disease in adulthood, Drake said. (
  • Different fetal MHC alleles can either render the fetus susceptible or play a protective role in the disease development. (
  • In the fetus, a cystic hygroma can progress to hydrops (an excess amount of fluid in the body) and eventually lead to fetal death. (
  • Mitochondrial fatty acid oxidation disorders in an affected fetus are associated with maternal diseases of pregnancy, including preeclampsia, acute fatty liver of pregnancy, and the hemolysis, elevated liver enzymes, and low platelets syndrome called HELLP. (
  • because the placenta provides the fetus with nutrients needed for growth and serves as an excretory organ to eliminate wastes from fetal metabolism, placental pathology profoundly affects the developing fetus. (
  • The cerebro-placental ratio (CPR) is a tool for assessment of fetal wellbeing in the management of the growth restricted fetus. (
  • Diagnosed with fetal hydrops, a condition caused when abnormal amounts of fluid build in two or more body areas of a fetus or newborn, Brianna Marie was born March 16, 2012, and only lived 15 hours. (
  • Moss and Adams' heart disease in infants, children, and adolescents : including the fetus and young adult. (
  • To create the statement, Donofrio and colleagues reviewed literature covering the diagnosis of congenital heart disease and arrhythmias, the assessment of cardiac function and the rest of the cardiovascular system, and the range of treatments available. (
  • Arunamata A, Punn R, Cuneo B, Bharati S, Silverman NH (2011) Echocardiographic diagnosis and prognosis of fetal left ventricular noncompaction. (
  • Acute placental inflammation (API), including maternal and fetal inflammatory responses corresponds to the clinical diagnosis of chorioamnionitis and is associated with respiratory and neurodevelopmental diseases. (
  • Research helps us better understand diseases and can lead to advances in diagnosis and treatment. (
  • Ambient air pollution and fetal growth restriction: Physician diagnosis of fetal growth restriction versus population-based small-for-gestational age. (
  • 4- 8 Currently, the disease is incurable and leads to death within about 20 years from diagnosis. (
  • Those parents turn to the UAB Fetal Diagnosis and Care Center for information, support, and medical care. (
  • Dr. Romp says expectant parents who meet with the UAB Fetal Diagnosis and Care Center team are better prepared for the road ahead. (
  • It is generally accepted that this condition is not a true diagnosis or a specific syndrome, but rather a description of a group of abnormalities resulting from fetal akinesia. (
  • Evaluation of prenatal diagnosis of associated congenital heart diseases by fetal ultrasonographic examination in Europe. (
  • Congenital heart disease/defects diagnosis? (
  • Parents who have received a fetal diagnosis need support and resources. (
  • Fetal Diseases diagnosis. (
  • The most severe condition is called fetal alcohol syndrome (FAS), which refers to individuals who have a specific set of birth defects and neurodevelopmental disorders characteristic of the diagnosis. (
  • Therefore, research was conducted to find a relationship between fetal under nutrition and future occurrence of hypertension or coronary heart disease in those adults. (
  • To further investigate the relationship between fetal cell microchimerism and SLE, we examined biopsy specimens of affected skin from women with previous male pregnancies affected with lupus as well as other skin disorders for the presence of male microchimeric cells. (
  • These findings may coexist as Syndrome X, more recently named as Metabolic Syndrome, and understood as precursory of coronary heart disease and cerebral stroke. (
  • lists trials that are related to Fetal thalidomide syndrome. (
  • She performs the full spectrum of pediatric surgery with a particular interest in minimal access surgery, management of the short bowel syndrome, and fetal surgical diagnoses and prenatal counseling. (
  • Fetal alcohol syndrome (FAS) and fetal alcohol syndrome disorder (FASD) are known to be associated with persistent physical and neurodevelopmental abnormalities (Vaux et al. (
  • Fetal Akinesia Deformation Sequence, also known as fetal akinesia sequence , is related to multiple pterygium syndrome, escobar variant and oligohydramnios . (
  • Women with lupus and antiphospholipid antibody syndrome are also at higher risk of fetal loss, arterial and venous thrombosis, renal vasculitis, and preeclampsia. (
  • Kinnear C, Haranal M, Shannon P, Jaeggi E, Chitayat D, Mital S. Abnormal fetal cerebral and vascular development in hypoplastic left heart syndrome. (
  • FAS (fetal alcohol syndrome) is the result of prenatal alcohol exposure. (
  • Although fetal alcohol syndrome is a common cause of mental retardation, however, it's preventable. (
  • The facial features that occur with fetal alcohol syndrome could also occur in normal children and only experts could distinguish normal facial features from those of fetal alcohol syndrome. (
  • Sometimes, other terms are used in describing some of the signs of fetal alcohol syndrome. (
  • Fetal alcohol syndrome occurs when a woman drinks alcohol while she is pregnant. (
  • The most severe form of the condition is known as fetal alcohol syndrome (FAS). (
  • Other types include Partial Fetal Alcohol Syndrome (pFAS), Alcohol-Related Neurodevelopmental Disorder (ARND), Static Encephalopathy, Alcohol-Related Birth Defects (ARBD), and Neurobehavioral Disorder Associated With Prenatal Alcohol Exposure (ND-PAE). (
  • The term fetal alcohol syndrome was first used in 1973. (
  • Partial fetal alcohol syndrome (pFAS) refers to individuals with a known, or highly suspected, history of prenatal alcohol exposure who have alcohol-related physical and neurodevelopmental deficits that do not meet the full criteria for FAS. (
  • As the next step to clinical translation, we also demonstrated the feasibility of ultrasound-guided global AAV gene transfer to fetal macaque brains. (
  • That includes a detailed discussion of the fetal echocardiogram -- the main tool for evaluating fetal cardiac disease -- and reviews of other tests, including advanced ultrasound, fetal magnetic resonance imaging, and fetal magnetocardiography and electrocardiography. (
  • Ultrasound shows evidence of fetal hydrops , such as swollen tissues and organs. (
  • Background Second trimester routine ultrasound evaluation of the fetal heart by means of the four-chamber view has been proposed for prenatal detection of cardiac anomalies. (
  • Pregnant women without known risk factors who were scheduled for a routine fetal ultrasound examination between 16 and 24 weeks gestation were invited to participate. (
  • The fetal four chamber-view examination was considered abnormal in 7 women who were subsequently referred for extensive fetal ultrasound examination. (
  • The aim of this pictorial review is to describe the technical advances achieved through the application of 4-dimensional (4D) ultrasound using spatiotemporal image correlation (STIC) over conventional 2-dimensional ultrasound in the prenatal detection of congenital heart disease (CHD). (
  • Moreover, using 4D ultrasound, echolucent structures can be converted into solid voxels generating "digital casts" of the fetal heart that enhances the understanding of the great vessel relationships in the ventricular inflow and outflow tracts. (
  • According to Luisa Wetta, MD, associate professor of Obstetrics and Gynecology in the UAB Department of Maternal & Fetal Medicine, congenital heart disease may be suspected as early as 18-20 weeks into the pregnancy, when the mother-to-be has an ultrasound. (
  • The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. (
  • w4 This led to the lifestyle model in understanding the aetiology of chronic diseases, where the key issues are health behaviour and the interaction between genes and an adverse environment in adult life. (
  • These historical cohort studies 3-5 w7 w8 and evidence from animal experiments 1 w9 suggest that chronic diseases are biologically "programmed" in utero or in early infancy. (
  • Longitudinal study of 13 517 men and women who were born in Helsinki University Hospital during 1924-1944, whose body sizes at birth and during childhood were recorded, and in whom deaths, hospital admissions, and prescription of medication for chronic disease are documented. (
  • To continue studies on the two major neurological complications of sickle cell disease (SCD): namely, stroke and chronic encephalopathy. (
  • Kramer MS . Association between restricted fetal growth and adult chronic disease: is it causal? (
  • A recent paper described the placenta as the "center of the chronic disease universe" ( 7 ). (
  • Placental inflammation is a sub-focus in the study of chronic disease risk, particularly within the context of the global obesity epidemic and low-level, chronic inflammation that is present in pregnant women with a high BMI. (
  • The world-renowned physician and professor who pioneered the theory linking fetal malnutrition to chronic adult disease will receive the March of Dimes Agnes Higgins Award for outstanding achievement in the field of maternal-fetal nutrition. (
  • By looking beyond conventional wisdom, which suggested that chronic disease is a function of adult lifestyle, Dr. Barker and his team of researchers discovered a causal relationship between a mother's nutrition and the health of her children as adults. (
  • These changes are permanent and lead to chronic disease, a process known as "the fetal programming of adult disease. (
  • His research is widely accepted and has paved the way for further research into the link between maternal-fetal nutrition and chronic diseases later in life such as diabetes, obesity and certain cancers. (
  • Hormonal Biomarkers for Evaluating the Impact of Fetal Growth Restriction on the Development of Chronic Adult Disease. (
  • Epidemiological challenges in studying the fetal origins of adult chronic disease. (
  • Parkinson's disease (PD) is a chronic condition where nerve cells in a small part of the brain called the substantia nigra become damaged and die. (
  • Chronic kidney disease also increases the risk of intrauterine growth retardation and preterm birth. (
  • Although the outlook has improved for women with certain types of chronic kidney disease who wish to bear children, the chance of a good pregnancy outcome in women with end-stage renal disease on dialysis remains poor. (
  • Diabetes mellitus (DM) is one of the most widespread chronic diseases worldwide. (
  • As a result of low oxygen levels, infants with PPHN are at an increased risk of developing complications, such as asphyxia, chronic lung disease, neurodevelopment issues, and death. (
  • Further exploration of the company's website reveals that the designation "'adult' (non-embryonic)" also turns out to mean "fetal. (
  • Debi Vinnedge, president of Children of God for Life, a Florida organization devoted to fighting the use of fetal-derived products in both the food and drug industries, said it was a long-established practice in biological research to term all non-embryonic cells, whether from fetal, infant or adult stages, as "adult" because they share important characteristics that set them apart from embryonic cells. (
  • Embryonic stem-cell research, which involves the killing of a unique human being in an attempt to cure different diseases, has proven not only destructive and costly, but has not produced a cure. (
  • As a feasible alternative to fetal ventral midbrain tissue, midbrain dopamine neurons can be derived from human embryonic stem cells or induced pluripotent stem cells. (
  • Fetal cell microchimerism develops in all human pregnancies 1 and has been associated with autoimmune diseases such as systemic sclerosis. (
  • Dr. Lakshmi Rajagopal, an associate professor of pediatrics at the University of Washington School of Medicine and expert on newborn infectious diseases at Seattle Children's Research Institute and UW Medicine, and Dr. Timothy Mitchell, an obstetrician specializing in high-risk pregnancies and a former UW Medicine fellow in maternal and fetal medicine, led the study with Adams Waldorf. (
  • Conclusions Our findings show that both fetal MHC and non-MHC genes regulate susceptibility to CHB and determine the fetal disease outcome in anti-Ro52 positive pregnancies. (
  • Women with this blood type who have experienced previous pregnancies may produce anti-Rh17 antibodies, which may cause severe fetal hemolytic anemia or fetal death in subsequent pregnancies. (
  • Our Maternal/Fetal Medicine group is a recognized referral center for high risk pregnancies from Central and Western Kentucky in addition to Southern Indiana. (
  • She shares the stories of women who had difficulty getting pregnant or maintaining pregnancies as a result of undiagnosed celiac disease and gluten sensitivity, and explains how a mass screening could work to prevent such intense suffering. (
  • Over the last 20-years, research by various experts in foetal abnormality detection has proved time and again that the 'NT-Test' is one of the most important markers of chromosomal abnormalities. (
  • 54 Fetal akinesia deformation sequence (FADS) is a condition characterized by decreased fetal movement (fetal akinesia) as well as intra-uterine growth restriction (IUGR), multiple joint contractures (arthrogryposis), facial anomalies, underdevelopment of the lungs (pulmonary hypoplasia) and other developmental abnormalities. (
  • 1st trimester screening for fetal chromosomal abnormalities is done between about 11 weeks and 13 weeks 6 days of pregnancy. (
  • Creasy and Resnik's Maternal-Fetal Medicine , 6th ed., pp. 477-503. (
  • This study, which was performed in conjuiction with St. Mary's Maternal Fetal Medicine and OBGYN Clinic, which is about 250 miles and two mountain passes away from the Children's Hospital Colorado's Heart Institute, is the first to look at the effects of a telecardiology program on the detection and risk stratification of fetal CHD in a medically underserved area. (
  • UAB Medicine's multidisciplinary team - which includes a maternal-fetal medicine physician such as Dr. Wetta, a genetics counselor, and a pediatric cardiologist - quickly steps in. (
  • But for those mothers and babies that require a higher level of expertise and knowledge, University of Louisville Physicians-Maternal-Fetal Medicine, practicing with the University of Louisville Hospital labor and delivery nursing staff, offer the most up-to-date techniques backed by top research. (
  • We report successful management of a pregnancy associated with fetal hemolytic disease owing to high titers of anti-Rh17 (1:4096) in a woman with a history of a pregnancy with fetal hydrops and intrauterine fetal death. (
  • In the new model, the investigators removed the adult mouse globin genes, and inserted the human fetal and adult genes in their places. (
  • Many of the genes with altered expression -- NPPA, MYH6 and ACE2 -- have known functions in heart development or are linked to heart disease. (
  • The authors hypothesised that fetal susceptibility to the maternal autoantibodies could be determined by fetal genes. (
  • In Lew.1AV1 rats, PR prolongation was induced in the pups already at 2 mg injections, indicating that fetal non-MHC genes can increase susceptability to CHB. (
  • In Lew.L rats, PR intervals were significantly more prolonged after 2 mg injections, indicating that fetal L MHC genes conferred to highest susceptibility to CHB. (
  • In Lewis.N rats however, no difference in the PR intervals were observed between the PBS-injected control group and groups injected with 2 or 4 mg of Ro52 monoclonal antibody, suggesting that specific fetal MHC genes can confer the resistance and play a protective role in the development of the CHB. (
  • The lipotoxicity seen in fetal livers persists into the postnatal period, illustrating that exposure to a high-fat diet during development enhances pediatric NAFLD risk. (
  • 10 Small body size or body shape at birth (or subsequently) has been seen as a marker of poor fetal nutrition, which, it is suggested, results in fetal adaptations that programme future propensity to adult disease. (
  • Changes in fetal growth pattern have been related to adult disease risk, 1 and there are many theories about the underlying mechanisms affecting cell division during critical periods of tissue development. (
  • The critical periods vary according to the tissue in question, and that is why there have been attempts to explore the timing of exposure in order to predict more specifically the adult disease risk. (
  • and thirdly the specific problems in longitudinal studies which explore these factors and adult disease risk. (
  • Studies of twins: what can they tell us about the fetal origins of adult disease? (
  • Morley R , Dwyer T . Fetal origins of adult disease? (
  • The developmental origins of adult disease. (
  • Previous studies have shown that T2DM is an adult disease, but it has been increasingly diagnosed in obese children in recent years 10 . (
  • Given the expanded roles of the pediatric cardiologist specializing in fetal medicine and the maternal fetal specialist as collaborative caregivers for fetuses with structural heart disease, arrhythmias, or cardiovascular dysfunction, a new standard of care for the practice of the multidisciplinary, rapidly advancing, and highly specialized field of fetal cardiac medicine is needed," they wrote. (
  • The likely mechanisms for the genotype-phenotype correlations in pediatric LCHAD deficiency and the fetal-maternal interaction are discussed. (
  • Alan Flake, MD , a pediatric and fetal surgeon and director of CHOP's Center for Fetal Research, is conducting research that aims to allow for replacement of abnormal blood forming stem cells with normal stem cells, with the hope that eventually, unborn babies treated with this preventative therapy will be born without any symptoms of sickle cell disease . (
  • Using animal models over the past 10 years, we have conducted live (in-vivo), in-utero studies of intrauterine growth retardation (IUGR) that closely parallels human IUGR and have created models of pediatric surgical diseases such as pure esophageal atresia and gastroschisis. (
  • She specializes in cardiac imaging and its application to the comprehensive evaluation of the fetal and pediatric heart, inclusive of congenital heart disease (CHD) and fetal arrhythmias. (
  • It is conceivable that fetal adaptation to the adverse conditions of intrauterine environment can determine permanent metabolic alterations that could bring repercussions in the adult life. (
  • found that the high-fat diet affects fetal metabolic development, independent of maternal diabetes and obesity. (
  • Extensive research has focused on maternal nutritional status and later metabolic disease in offspring, but some of the most striking DOHaD findings come from examination of the long term impact of exposure to inflammation. (
  • Metabolic alterations during intrauterine growth restriction can modify the fetal programming. (
  • The present nonsystematic review intended to summarize historical and current references that indicated that developmental origins of health and disease (DOHaD) occur as a consequence of altered maternal and fetal metabolic pathways. (
  • These findings suggest that many pathways related to fetal heart development may be impacted by inflammation and infection,' said Mitchell. (
  • Sickle Cell Disease (SCD) is a hereditary anemia that causes the red blood cells to change their shape from a round and doughnut-like shape to a half-moon/crescent, or sickled shape. (
  • Sickle cell disease is one of the most common hereditary diseases. (
  • Studies in humans have shown that men and women whose birth weights were at the lower end of the normal range, who were thin or short at birth, or who were small in relation to placental size have increased rates of coronary heart disease. (
  • The early epidemiological studies that pointed to the possible importance of programming in coronary heart disease were based on the simple strategy of examining men and women in middle and late life whose body measurements at birth were recorded. (
  • Geographic areas with a high recent incidence of coronary heart disease match areas showing a high rate of infant mortality in the beginning of the twentieth century. (
  • For example, in the mid 1980s Rose pointed out that the well established risk factors for coronary heart disease (CHD)-cigarette smoking, high serum cholesterol, and high blood pressure-have a limited ability to predict disease risk in adults. (
  • Fetal growth and coronary heart disease in south India. (
  • Coronary heart disease is predicted to become the commonest cause of death in india within 15 years People from India living overseas already have high rates of the disease that are not explained by known coronary risk factors. (
  • Small size at birth is a newly described risk factor for coronary heart disease, but associations between size at birth and the disease have not been examined in India. (
  • We related the prevalence of coronary heart disease, defined by standard criteria, to their birth size. (
  • 25 (9%) men and 27 (11%) women had coronary heart disease. (
  • In India, as in the UK, coronary heart disease is associated with small size at birth, suggesting that its pathogenesis is influenced by events in utero. (
  • People from India living overseas have high rates of coronary heart disease which are not explained by known coronary risk factors. (
  • In India, coronary heart disease is predicted to become the most common cause of death within 15 years. (
  • Small size at birth is a newly described risk factor for coronary heart disease. (
  • Low birthweight has been consistently shown to be associated with coronary heart disease (CHD) and its biological risk factors. (
  • Coronary heart disease and type 2 diabetes may originate through two widespread biological phenomena-developmental plasticity and compensatory growth. (
  • The common pathophysiological mechanisms underlying the development of PVD and other atherosclerotic diseases are reflected in the fact that patients often have concomitant coronary artery and cerebrovascular disease. (
  • Over the last 20 years, a number of studies have established the importance of birth weight as a determinant of both coronary heart disease and cerebrovascular mortality. (
  • Part of the reason for this may lie in the lower public profile of PVD, as compared with coronary heart disease. (
  • In addition, unlike coronary artery and cerebrovascular disease, PVD is not a fatal condition in itself, and is rarely listed as a contributory factor on death certificates. (
  • 5 Moreover, there has been a growing awareness of the importance of PVD as not only a marker, but a predictor of coronary artery disease. (
  • Given the close relation between PVD and coronary heart disease, a condition which itself has been shown to be associated with low birth weight, 1 it is surprising that only one study has directly analysed the influence of fetal environment on the risk of developing PVD. (
  • While the U-shaped relationship between birthweight and risk of heart disease has been reported across numerous studies and populations, less recognized is the similar U-shaped relationship between the ratio of placental weight to birthweight and coronary heart disease ( 8 , 9 ). (
  • More than 20 years ago, Dr. Barker showed for the first time that people who had low birthweight are at greater risk of developing coronary heart disease. (
  • Dr. Barker began his work by exploring why historically poorer areas of England and Wales had disproportionately high death rates from coronary heart disease than other areas. (
  • In the past, women with diabetic nephropathy tended to have a high rate of maternal complications, including overt nephropathy, hypertension, and death due to unrecognized coronary artery disease. (
  • DENVER, CO--(Marketwired - Nov 9, 2016) - The Fetal Health Foundation (FHF) has named Dr. Deprest of the Katholieke Universiteit of Leuven (Belgium) and the University College of London Institute for Women's Health the recipient of the 2016 Brianna Marie Memorial Research Grant. (
  • N-terminal pro-B-type natriuretic peptide: a potential marker of fetal heart failure in hemolytic disease. (
  • The fetal serum concentration of NT-proBNP appears to be a satisfactory marker for heart failure in fetuses inflicted with severe anaemia caused by hemolytic disease. (
  • Luterek A, Szymusik W, Bartkowiak O, Koltowski U, Filipiak R, Wielgos I, N-terminal pro-B-type natriuretic peptide: a potential marker of fetal heart failure in hemolytic disease. (
  • Successful management of fetal hemolytic disease due to strong anti-Rh17 with plasma exchange and intrauterine transfusion in a woman with the D-- phenotype. (
  • With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. (
  • The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal circulation. (
  • However, LifeSite News, the Toronto-based pro-life news organization, dug into the firm's website to find "human neural stem cells" described more brutally as "fresh human fetal brain tissue. (
  • The aim of this study was to test the safety and possible benefits of a novel strategy based on grafting human fetal brain stem cells (hfSCs) I the hope that they help address both dopamine and non-dopamine aspects of the disease. (
  • Undifferentiated human fetal brain-derived stem cells grafted into putamina of parkinsonian patients is safe and moderately effective: a phase I clinical trial. (
  • If undifferentiated human fetal brain-derived stem cells (hfSC) are transplanted in the putamina, then patients will Parkinson's Disease will not suffer harm and will decrease their disease. (
  • The authors also discussed the benefits of being able to diagnose fetal cardiac disease and initiate management before delivery, which allows counseling of the parents and prediction of the clinical course of disease in preparation for delivery. (
  • The purpose of this study is to determine the safety and clinical effects of SCD-101 when given to adults with sickle cell disease. (
  • The goal for in utero stem cell therapy is to treat sickle cell disease before any clinical manifestations of the disease occur. (
  • Dr Marc Althuser from the Fetal Medicine Department, the University Hospital of Grenoble, France, believes the future for Auto NT testing is bright: "I am in the process of completing a multicenter clinical trial into the benefits of using a semi-automated testing protocol, and the results look very positive. (
  • Her recent basic science and clinical work reflect her continuing interest in fetal gastrointestinal development and the mechanisms of gastrointestinal (GI) absorption and motility during the last trimester of gestation. (
  • Transplantation of human primary fetal tissue is now well established for cellular repair in Parkinson's disease (PD), with good evidence of clinical benefit. (
  • However, the recent BMJ Clinical Evidence overview identified only two US RCTs of fetal neural tissue transplantation. (
  • Among the major challenges of fetal ventral midbrain neuron transplants that need to be addressed in future clinical trials are technical improvements in cell preparation and delivery and standardized protocols, proper patient selection, reduction of side effects (dyskinesias) and the need for immunosuppression. (
  • CHICAGO - Tight blood pressure control is crucial in caring for pregnant women with diabetic nephropathy, but medication management must factor in potential fetal risks, Dr. Phyllis August said at a meeting on clinical nephrology sponsored by the National Kidney Foundation. (
  • The placenta is the first organ to form and is the site of juxtaposition between the maternal and fetal circulations. (
  • Most diseases of pregnancy are caused by, impact, or are reflected in the placenta. (
  • The purpose of this review is to describe the main inflammatory processes in the placenta, discuss their immunology, and relate their short- and long-term disease associations. (
  • We know that viruses can take a variety of routes to the fetal compartment, but we have also learned that the placenta has a robust level of inherent resistance to viruses. (
  • Some viruses may be carried by macrophages or other immune cells through the placenta and into the fetal compartment, while others colonize the uterine cavity prior to conception, ready to proliferate during pregnancy. (
  • Thus human placenta derives energy from fatty acid oxidation, providing a potential explanation for the association of fetal fatty acid oxidation disorders with maternal liver diseases in pregnancy. (
  • The placenta requires a constant and abundant source of energy to supply the needs for its own rapid growth and maturation and to transport the nutrients, ions, vitamins, waste, and other molecules required for fetal growth and homeostasis from the maternal to the fetal circulation and vice versa. (
  • A common belief among fetal physiologists ( 14 , 16 , 18 , 20 , 26 ) is that glucose transported to and across the placenta from the maternal circulation provides all placental and fetal energy needs via glycolysis and the citric acid cycle. (
  • Thyroid hormones are particularly necessary to assure healthy fetal development of the brain and nervous system during the first three months of your pregnancy since the baby depends on your hormones, which are delivered through the placenta. (
  • 1, 2 By contrast there has been very little work investigating the possible influence of the prenatal environment on the later development of peripheral vascular disease. (
  • The purpose of this activity is to improve the skill and confidence of sonographers and physicians in the performance and evaluation of screening fetal heart views and images, in order to improve prenatal detection of congenital heart disease. (
  • Hyperthyroid disease -The most common cause of maternal hyperthyroidism during pregnancy is the autoimmune disorder Grave's disease . (
  • Hypothyroid disease -The most common cause of hypothyroidism is the autoimmune disorder known as Hashimoto's thyroiditis . (
  • Huntington's disease (HD) is an inherited neurodegenerative disorder typically presenting in midlife with a movement disorder, dementia, and psychiatric manifestations. (
  • Parkinson's disease (PD) is a neurodegenerative disorder characterized by the selective loss of nigrostriatal dopaminergic neurons which results in the cardinal symptoms of tremor, rigidity, bradykinesia, and postural instability. (
  • The range of disorder collectively is known as FASD (fetal alcohol spectrum disorders). (
  • The research involved the use of NHPs due to their similarity to humans in the development of the central nervous system, and other organs, allowing for an accurate model to be achieved in fetal gene transfer. (
  • To characterize the safety and tolerability of vorinostat in subjects with sickle cell disease. (
  • To determine the retinal and choroidal thickness in patients with sickle cell disease compared to age, race matched population without sickle cell disease to allow a better understanding o. (
  • Classic pseudoxanthoma elasticum in a girl with sickle cell disease. (
  • A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. (
  • Oxidative stress contributes to the complex pathophysiology of sickle cell disease. (
  • R60 and the percentage of dense cells are not affected by the association of sickle cell disease with the deletion of one alpha gene. (
  • Response from the Authors of Effects of nutritional intake on disease severity in children with sickle cell disease. (
  • It is designed to asses the safety and feasibility of administration of ALD-601 UCB cells to first trimester fetuses known to be affected with a lethal lysosomal storage disease. (
  • Many women who carried LCHAD-deficient fetuses developed maternal liver disease. (
  • In his 1995 encyclical Evangelium Vitae , John Paul said, "This moral condemnation also regards procedures that exploit living human embryos and fetuses - sometimes 'produced' for this purpose by in vitro fertilization - either to be used as 'biological material' or as providers or organs or tissue for transplants in the treatment of certain diseases. (
  • StemCells's patented HuCNS-SC cells are derived from the central nervous system of fetuses and designed to treat diseases affecting all parts of the system, including the eyes. (
  • Further, they found that three patients with recurrent spontaneous abortion (8%) and six patients whose fetuses had growth retardation (15%) tested positive for celiac disease. (
  • Fetal growth restriction refers to fetuses that fail to reach their growth potential. (
  • Fetal tissue as a transplantable cell source, obtained from induced abortions, may raise ethical concerns, also fetal tissue has a relatively low yield of dopaminergic neurons, and therefore tissue from several fetuses is required. (
  • The cause effect relationship between low birth weight and hypertension needs more accurate population growth analysis, including fetal biology, follow-up during childhood and adolescence, and determination of adult body mass index. (
  • These diseases are known to cause severe and irreversible neurological disability in early infancy and which are lethal in childhood. (
  • The purpose of this study is to determine the safety of first trimester fetal stem cell therapy using unrelated donor partially HLA-matched stem and progenitor cells derived from human umbilical cord blood for the treatment of selected lysosomal storage diseases that are known to cause severe and irreversible neurological disability in early infancy and which are lethal in childhood. (
  • To quantify the importance of developmental processes in the genesis of CHD it is necessary to establish the impact of fetal, infant and childhood growth on major pathological events in later life-death, hospital treatment and the need for medication. (
  • Barker DJ, Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. (
  • Conclusion In term infants, IUGR is linked to risk of hypertension in early childhood, which may be a marker for adult cardiovascular disease. (
  • History of Maternal Fetal Loss and Childhood Leukaemia Risk in Subsequent Offspring : Differentials by Miscarriage or Stillbirth History and Disease Subtype. (
  • Archives of Disease in Childhood is a peer-reviewed medical journal published by the BMJ Group and covering the field of paediatrics . (
  • who opposes most fetal tissue research because of its association with abortion, intends to issue the subpoenas on behalf of the Republicans on the House Select Investigative Panel on Infant Lives. (
  • The authors report a safety study of unilateral transplantation of human fetal striatal tissue into the striatum of four patients with HD. (
  • Unilateral transplantation of human fetal striatal tissue in patients with HD is safe and feasible. (
  • As an alternative to pharmacological therapy or electrostimulation, cell-based therapies that reconstruct the nigrostriatal pathways have been developed with the transplantation of fetal ventral midbrain neurons into the striatum of PD patients. (
  • Several open label studies provided proof of principle of the effectiveness and safety of such fetal neural transplantation. (
  • Both trials utilized solid fetal neural tissue for transplantation which may be inferior to cell suspension grafts used in previous open label studies. (
  • After a moratorium of neural transplantation for a decade, partly due to the results of these two U.S. RCTs, a multicentre European study, the TRANSEURO Open Label Transplant Study in Parkinson's Disease, is currently ongoing to assess the safety and efficacy of neural transplantation with fetal ventral mesencephalic tissue in patients with Parkinson's disease, with randomized allocation to transplantation or sham surgery. (
  • Deficiency of hormones was historically the first indication for fetal cell transplantation. (
  • The same is not true with the excessive production of hormones: hyperfunction of any endocrine gland is an indication for fetal cell transplantation only in the case that an antagonist of the hormone is known, and is produced by a specific cell type, that is then used for cell transplantation treatment. (
  • Rarely do we in the Unites States consider a gravida's vulnerability to tropical infectious diseases such as dengue, chikungunya, and now Zika. (
  • The American Heart Association has released a scientific statement that highlights what is currently known and recommended on the basis of evidence and experience in the rapidly advancing and highly specialized field of fetal cardiac care. (
  • The field of fetal cardiac medicine has expanded greatly in recent decades along with advances in imaging, according to a writing group chaired by Mary Donofrio, MD , of Children's National Medical Center in Washington. (
  • It's exciting to see the groundbreaking work that is occurring in the field of fetal health medicine," says El-Prince. (
  • Liver disease in pregnancy and fetal fatty acid oxidation defects. (
  • In the fetal period, from nine weeks after conception onwards, there begins the phase of rapid growth that continues until after birth. (
  • The main feature of fetal growth is cell division. (
  • Since McCance's studies in the 1960s on the long term effects of early nutrition in rats, 4 numerous animal studies have shown that nutrition in infancy or fetal life can induce lifetime effects on metabolism, growth, and neurodevelopment and on major disease processes such as hypertension, diabetes, atherosclerosis, and obesity. (
  • The earliest evidence showing the relation between Intrauterine Growth Restriction and occurrence of adult cardiovascular diseases stems from retrospective epidemiological studies. (
  • This Spotlight Issue of Microcirculation contains six current perspectives on the role of the intrauterine environment, especially maternal nutritional status and maternal diabetes in influencing fetal growth and cardiovascular heath in the offspring in later life. (
  • In addition, heart disease in pregnancy is associated to an increased rate of fetal growth restriction, premature birth, preeclampsia and other pregnancy complications for the mother and the baby. (
  • 08/13/2000) According to a recent study by Dr. Antonio Gasbarrini and colleagues from Gemelli Hospital, Catholic University, in Rome, celiac disease may play a role in recurrent spontaneous abortion and intrauterine fetal growth retardation. (
  • According to Dr. Antonio Gasbarrini: The patients with recurrent spontaneous abortion and those with intrauterine fetal growth retardation had a significantly higher frequency of serological markers of celiac disease than controls, as reported in the July 29th issue of The Lancet. (
  • Their research shows that it is important to recognize celiac disease as a possible risk factor for recurrent spontaneous abortion and intrauterine fetal growth retardation, but it remains to be seen whether the removal of gluten from the diet will decrease the incidence of both problems for women with celiac disease. (
  • The purpose is to highlight the potential implications of growth factors and adipokines in "developmental programming", which could interfere in the development by controlling fetal growth patterns. (
  • Ambient air pollution may affect fetal growth restriction (FGR) through several mechanisms. (
  • Studies within siblings may be useful to disclose fetal growth restriction in appropriate for gestational age (AGA. (
  • Defining early versus late fetal growth restriction by placental pathology. (
  • The Relationship Between the Placental Serotonin Pathway and Fetal Growth Restriction. (
  • This is a Randomized Controlled Trial to evaluate the effect of sildenafil on Doppler velocity indices of the umbilical arteries in patients with placental insufficiency and fetal growth r. (
  • 58 The fetal akinesia deformation sequence (FADS) refers to a clinically and genetically heterogeneous constellation of features including fetal akinesia, intrauterine growth retardation, arthrogryposis, and developmental anomalies, including lung hypoplasia, cleft palate, and cryptorchidism (Vogt et al. (
  • Maternal and fetal Low Density Lipoprotein-Cholesterol (LDL-C) concentrations are compromised in intrauterine growth restriction (IUGR). (
  • Our results suggest that PCSK9 play a role in impaired fetal growth by controlling fetal LDL-C metabolism, which seems to be dependent on gestational age and fetal gender. (
  • Mutations in the GBA gene, which encodes the GCase enzyme that is deficient in Gaucher disease, are also a risk factor for Parkinson's disease. (
  • The House investigation into how some of the nation's most prestigious universities acquire fetal tissue has prompted charges of intimidation and coercion, escalating a battle that some researchers fear could shut down studies seeking cures for Parkinson's disease, the Zika virus and a host of other conditions. (
  • More recently, deep brain stimulation of the pallidum or subthalamic nucleus is being used, which effectively controls the motor symptoms of Parkinson's disease. (
  • He was also a postdoctoral research fellow for three years at Harvard University, USA, studying neural repair and cell therapy for Parkinson's disease. (
  • Patients with moderate to severe Parkinson's disease. (
  • This novel model recapitulated placentomegaly associated with BWS, but did not lead to fetal overgrowth. (
  • The aim of the current study was to investigate changes in fetal NT-proBNP serum concentrations before and after intrauterine transfusions and to assess its value as a marker of fetal heart failure. (
  • The hemolysis of red blood cells due to isoimmunisation results in fetal anaemia and hypoxia leading to fetal heart failure. (
  • Fetal gene therapy for neurodegenerative disease of infants. (
  • A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore. (
  • We found that the mice who received an injection of adeno-associated virus (AAV) vector were more able to break down fatty chemicals and re-express the gene encoding an enzyme that is deficient in Gaucher disease," said Dr Simon Waddingdon (UCL Institute for Women's Health). (
  • This new approach will bring hope, not only for Gaucher disease, but also for other inborn errors of metabolism that can potentially be treated using fetal gene therapy," said Associate Professor Jerry Chan, Senior Consultant, Department of Reproductive Medicine, KK Women's and Children's Hospital. (
  • The team, which also involved scientists from King's College London, Imperial College London, the University of Oxford and an international team of researchers, are now engaged with Apollo Therapeutics in developing gene therapy for Gaucher disease. (
  • The motivation for our research is to understand the basic mechanisms of gene regulation in order to cure human disease," says Thomas Ryan of the University of Alabama Birmingham, who led the research. (
  • This study connects the dots between preterm birth and heart disease in adult life by defining the gene networks disrupted by infection and inflammation that program normal heart development,' said lead author Dr. Kristina Adams Waldorf, a professor of obstetrics and gynecology at the University of Washington School of Medicine who specializes in maternal and fetal infections. (
  • This study is the first to show that the gene program for heart development in preterm babies is interrupted in preterm babies exposed to fetal infection and inflammation, which may lead to incomplete heart development,' said Mitchell. (
  • The investigators compared gene expression patterns from fetal heart tissues infected with bacteria to normal heart tissues. (
  • This disease is caused by mutations in the Fah1 gene that codes for an enzyme involved in tyrosine breakdown. (
  • Huntington's disease (HD) is an inherited autosomal dominant condition in which there is a CAG repeat expansion in the huntingtin gene of 36 or more. (
  • An important gene associated with Fetal Akinesia Deformation Sequence is RAPSN (Receptor Associated Protein Of The Synapse), and among its related pathways/superpathways are Agrin Interactions at Neuromuscular Junction and Succinylcholine Pathway, Pharmacokinetics/Pharmacodynamics . (
  • Results on the association of maternal history of fetal loss (miscarriage/stillbirth) with specific disease subtypes in the subsequent offspring are in conflict. (
  • Statistically significant exposure and disease subtype-specific associations of previous miscarriage(s) exclusively with AML [odds ratio (OR) 1.67, 95% confidence interval (CI) 1.00, 2.81] and stillbirth(s) with ALL [OR 4.82, 95% CI 1.63, 14.24] and B-ALL particularly, emerged. (
  • Our mission is to build healthier lives, free of cardiovascular diseases and stroke. (
  • There is growing evidence of an increasingly complex and multifactorial aetiology of heart diseases. (
  • Untreated thyroid diseases during pregnancy may lead to premature birth, preeclampsia (a severe increase in blood pressure), miscarriage, and low birth weight among other problems. (
  • Significant renal disease is associated with preeclampsia and renal complications," she noted. (
  • It appears, therefore, that the Zika virus invades the intrauterine cavity by crossing the trophoblasts, perhaps earlier in pregnancy and prior to the development of full trophoblast resistance, by entering through breaks in this outer layer, or by utilizing alternative pathways to access the fetal compartment. (
  • We need a better understanding of how bacteria invade the uterus to cause preterm birth so that we can develop therapies to prevent fetal infections. (
  • A national survey of paediatricians in Ireland regarding Fetal Alcohol Spectrum Disorders. (
  • Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy. (
  • Fetal alcohol spectrum disorders are caused by a mother drinking alcohol during pregnancy. (
  • Fetal alcohol spectrum disorders are preventable by avoiding alcohol. (
  • The Doppler peak systolic velocity in the middle cerebral artery was 0.8 m/s, indicating severe fetal anemia. (
  • The Children's Environmental Health and Disease Prevention Research Center at Dartmouth invites applications for an interdisciplinary postdoctoral training and career development program in the fields of epidemiology, biostatistics and bioinformatics. (
  • Low birthweight, short birth length, and small head circumference at birth were associated with a raised prevalence of the disease. (
  • The highest prevalence of the disease (20%) was in people who weighted 5.5 lb (2.5 kg) or less at birth and whose mothers weighted less than 100 lb (45 kg) in pregnancy. (
  • The prevalence of fetal macrosomia in developed countries has increased by some 15-25% in recent decades, an increase largely attributed to increasing maternal obesity and diabetes. (
  • Fetal and placental size and risk of hypertension in adult life. (
  • Despite the progress in neonatology, too many newborns die due to respiratory insufficiency and pulmonary hypertension, and many others suffer significant pulmonary disease," Deprest stated. (
  • In addition, we will appraise the evidence that birth weight is associated with the development of this disease. (
  • As these presets include patient's age, weight, and stage in pregnancy, this is another development that will improve the accuracy of foetal testing, as well as saving considerable operator time. (
  • This has led to the concept of fetal programming, suggesting that the environment experienced in the womb can affect development, resulting in an increased risk of later disease. (
  • This new research showed that although birth weight is reduced in the offspring of male or female rats that were exposed to dexamethasone during fetal development, this effect was more pronounced in the offspring of male rats exposed to excess glucocorticoids during development in the womb. (
  • I would like to share a few of our ideas and progress in the laboratory in studying fetal gastrointestinal development during the last trimester of gestation. (
  • This passage of amniotic fluid, a form of fetal nutrition, appears necessary for normal gastrointestinal development. (
  • We are currently studying the fetal development (ontogeny) of motilin, a peptide with promotility effects in the stomach and small intestine. (
  • Thyroid hormones are necessary for normal fetal development during the first 3 months. (
  • The funds awarded to Dr. Deprest's study will be used to target prevention of congenital diaphragmatic hernia (CDH), an anomaly that disturbs lung development during fetal life. (
  • Earlier studies on antibiotics exposure and development of IBD (Crohn's disease (CD) and ulcerative colitis (UC)) may have been biased by familial factors and gastroenteritis. (
  • We know that undiagnosed celiac disease has a significant impact on maternal health and fetal development, and we must identify expectant mothers (and fathers) who have the potential to reap remarkable benefits from a simple diet change. (