Pathophysiological conditions of the FETUS in the UTERUS. Some fetal diseases may be treated with FETAL THERAPIES.

Increased phosphoglycerate kinase in the brains of patients with Down's syndrome but not with Alzheimer's disease. (1/1979)

Impaired glucose metabolism in Down's syndrome (DS) has been well-documented in vivo, although information on the underlying biochemical defect is limited and no biochemical studies on glucose handling enzymes have been carried out in the brain. Through gene hunting in fetal DS brain we found an overexpressed sequence homologous to the phosphoglycerate kinase (PGK) gene. This finding was studied further by investigating the activity levels of this key enzyme of carbohydrate metabolism in the brains of patients with DS. PGK activity was determined in five brain regions of nine patients with DS, nine patients with Alzheimer's disease and 14 controls. PGK activity was significantly elevated in the frontal, occipital and temporal lobe and in the cerebellum of patients with DS. PGK activity in corresponding brain regions of patients with Alzheimer's disease was comparable with controls. We conclude that our findings complement previously published data on impaired brain glucose metabolism in DS evaluated by positron emission tomography in clinical studies. Furthermore, we show that in DS, impaired glucose metabolism, represented by increased PGK activity, is a specific finding rather than a secondary phenomenon simply due to neurodegeneration or atrophy. These observations are also supported by data from subtractive hybridization, showing overexpressed PGK in DS brains at the transcriptional level early in life.  (+info)

Can transvaginal fetal biometry be considered a useful tool for early detection of skeletal dysplasias in high-risk patients? (2/1979)

OBJECTIVE: To evaluate the possibility of an early diagnosis of skeletal dysplasias in high-risk patients. METHODS: A total of 149 consecutive, uncomplicated singleton pregnancies at 9-13 weeks' amenorrhea, with certain menstrual history and regular cycles, were investigated with transvaginal ultrasound to establish the relationship between femur length and menstrual age, biparietal diameter and crown-rump length, using a polynomial regression model. A further eight patients with previous skeletal dysplasias in a total of 13 pregnancies were evaluated with serial examinations every 2 weeks from 10-11 weeks. RESULTS: A significant correlation between femur length and crown-rump length and biparietal diameter was found, whereas none was observed between femur length and menstrual age. Of the five cases with skeletal dysplasias, only two (one with recurrent osteogenesis imperfecta and one with recurrent achondrogenesis) were diagnosed in the first trimester. CONCLUSIONS: An early evaluation of fetal morphology in conjunction with the use of biometric charts of femur length against crown-rump length and femur length against biparietal diameter may be crucial for early diagnosis of severe skeletal dysplasias. By contrast, in less severe cases, biometric evaluation appears to be of no value for diagnosis.  (+info)

Comparison of prenatal ultrasound and postmortem findings in fetuses and infants with congenital heart defects. (3/1979)

OBJECTIVE: Detection of congenital heart defects by prenatal ultrasound examination has been one of the great challenges since the investigation for fetal anomalies became part of the routine fetal examination. This prospective study was designed to evaluate the concordance of prenatal ultrasound findings with autopsy examination in a population consisting of both referred women and non-selected pregnant women. DESIGN: Criteria for inclusion were an ultrasound examination at the National Center for Fetal Medicine and an autopsy performed during the years 1985-94. Results from the ultrasound and autopsy examinations were systematized into categories depending on the degree of concordance. RESULTS: Of 408 infants and fetuses with developmental anomalies, 106 (26%) had congenital heart defects. In 63 (59%) of these 106 cases, the heart defect was the principal reason for the termination of pregnancy or the cause of death. Excluding five cases with a secundum atrial septal defect, there was complete agreement between the ultrasound examination and the autopsy findings in 74 (73%) of 101 cases. In 18 cases, there were minor discrepancies between ultrasound and autopsy findings. The main diagnosis was thus correct in 92 cases (91%). From the first time period (1985-89) to the second (1990-94), the detection rate of all heart defects increased from 48% to 82%. CONCLUSION: This study confirms a good correlation between ultrasound and autopsy diagnoses in fetuses and infants with congenital heart defects. A significant improvement in the detection of heart defects occurred from the first time period to the second and was probably due to increased experience and technical advances.  (+info)

Diagnosis of twin reversed arterial perfusion sequence in the first trimester by transvaginal color Doppler ultrasound. (4/1979)

A case of twin reversed arterial perfusion (TRAP) sequence was diagnosed at 12 weeks' gestation using transvaginal color Doppler ultrasound, which demonstrated the presence of retrograde perfusion in the umbilical artery of the abnormal twin. Ultrasound imaging showed a monochorionic-diamniotic twin pregnancy with an inappropriately grown second twin, the morphological evaluation of which revealed an abnormal cephalic pole with acrania, diffuse subcutaneous edema and the presence of cardiac activity in an abnormal heart with a single chamber.  (+info)

Amylopectinosis in fetal and neonatal Quarter Horses. (5/1979)

Three Quarter Horses, a stillborn filly (horse No. 1), a female fetus aborted at approximately 6 months of gestation (horse No. 2), and a 1-month-old colt that had been weak at birth (horse No. 3), had myopathy characterized histologically by large spherical or ovoid inclusions in skeletal and cardiac myofibers. Smaller inclusions were also found in brain and spinal cord and in some cells of all other tissues examined. These inclusions were basophilic, red-purple after staining with periodic acid-Schiff (both before and after digestion with diastase), and moderately dark blue after staining with toluidine blue. The inclusions did not react when stained with Congo red. Staining with iodine ranged from pale blue to black. Their ultrastructural appearance varied from amorphous to somewhat filamentous. On the basis of staining characteristics and diastase resistance, we concluded that these inclusions contained amylopectin. A distinctly different kind of inclusion material was also present in skeletal muscle and tongue of horse Nos. 1 and 3. These inclusions were crystalline with a sharply defined ultrastructural periodicity. The crystals were eosinophilic and very dark blue when stained with toluidine blue but did not stain with iodine. Crystals sometimes occurred freely within the myofibers but more often were encased by deposits of amylopectin. This combination of histologic and ultrastructural features characterizes a previously unreported storage disease in fetal and neonatal Quarter Horses, with findings similar to those of glycogen storage disease type IV. We speculate that a severe inherited loss of glycogen brancher enzyme activity may be responsible for these findings. The relation of amylopectinosis to the death of the foals is unknown.  (+info)

Whence the arthrogrypotics? (6/1979)

During the course of a nation-wide survey of patients with bone and joint deformities, twenty-six individuals with arthrogryposis multiplex congenita, in the narrow and precise sense of the term, were investigated. No patient was more than twenty-four years of age. However, on a basis of the figures of population, it can be estimated that 21-0 +/- 6-5 older affected individuals should have been encountered. Furthermore, there was a relative excess of younger children. The series was reasonably unbiased, and as arthrogryposis is non-lethal the deficiency of affected adults is an anomalous finding. It is tentatively suggested that arthrogryposis might result from the intra-uterine influence of an unknown environmental agent which has been present in South Africa for only a limited period of time. Detection of this factor could be an important step in the prevention of the disease.  (+info)

Neurological morbidity after fetal supraventricular tachyarrhythmia. (7/1979)

BACKGROUND: Fetal tachyarrhythmia is a well-documented entity which, in the absence of pharmacological intervention, may lead to congestive heart failure, fetal hydrops and eventually fetal demise. The success rate of the implemented treatment is generally measured by survival and achievement of control of the arrhythmia. We report on the occurrence of associated cerebral damage in three patients with fetal tachycardia. METHODS: We describe three patients with a history of fetal supraventricular tachyarrhythmia who developed cerebral complications in utero. RESULTS: Two patients had cerebral hypoxic-ischemic lesions and one had hemorrhagic lesions present at birth. They had developed severe congestive heart failure and fetal hydrops secondary to fetal tachyarrhythmia, and there were no other obvious causes for the cerebral pathology. Two of these patients were referred to us antenatally. Therapy was instituted and resulted in control of the tachycardia and resolution of hydrops. The third patient was referred to our clinic shortly after birth because of severe circulatory problems secondary to fetal tachyarrhythmia. CONCLUSION: From these observations, we believe that a fetus with tachyarrhythmia and subsequent hydrops is at increased risk for the development of cerebral complications, due to the circulatory disturbances and sudden changes in heart rate which may lead to fluctuations in cerebral perfusion. This would imply that it is of the utmost importance to aim at immediate and complete control of the heart rate in the treatment of fetal tachyarrhythmia.  (+info)

Trisomy 10: first-trimester features on ultrasound, fetoscopy and postmortem of a case associated with increased nuchal translucency. (8/1979)

We report a case of the prenatal diagnosis of trisomy 10 in a fetus presenting with an increased nuchal translucency thickness (5 mm) on a routine first-trimester anomaly scan at 12 weeks' gestation. Multiple abnormalities were diagnosed by ultrasound and fetoscopy. Karyotyping on chorionic villus sampling led to the diagnosis of homogeneous trisomy 10 which was confirmed by in situ hybridization on fetal tissue samples. Postmortem examination confirmed major anatomical malformations, including facial cleft, arthrogryposis of the upper and lower limbs and bilateral diaphragmatic hernia, and also revealed hypoplastic lungs, right renal agenesis and a complex cardiac malformation. Trisomy 10 is an uncommon chromosomal abnormality that is likely to be associated with increased fetal nuchal translucency. This case also emphasizes the value of a detailed anomaly scan in high-risk patients in the first trimester of pregnancy.  (+info)

Fetal diseases are medical conditions or abnormalities that affect a fetus during pregnancy. These diseases can be caused by genetic factors, environmental influences, or a combination of both. They can range from mild to severe and may impact various organ systems in the developing fetus. Examples of fetal diseases include congenital heart defects, neural tube defects, chromosomal abnormalities such as Down syndrome, and infectious diseases such as toxoplasmosis or rubella. Fetal diseases can be diagnosed through prenatal testing, including ultrasound, amniocentesis, and chorionic villus sampling. Treatment options may include medication, surgery, or delivery of the fetus, depending on the nature and severity of the disease.

Archives of Disease in Childhood. Fetal and Neonatal Edition. 70 (2): F155-6. doi:10.1136/fn.70.2.f155. PMC 1061019. PMID ... Persistent fetal circulation is a condition caused by a failure in the systemic circulation and pulmonary circulation to ... Persistent fetal circulation in neonates can be reversible or irreversible depending on the classified etiology listed above. ... The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal ...
... at Curlie Center for Disease Control's page on Fetal Alcohol Spectrum Disorders (FASDs) ( ... 96-06). Seattle: University of Washington, Fetal Alcohol and Drug Unit. Malbin, D. (1993). Fetal Alcohol Syndrome, Fetal ... "Fetal Alcohol Spectrum Disorders (FASDs)". Center for Disease Control. Archived from the original on 28 July 2017. Retrieved 9 ... Fetal alcohol syndrome (FAS) Partial fetal alcohol syndrome (pFAS) refers to individuals with a known, or highly suspected, ...
Speer, C. P. (2011). Neonatal respiratory distress syndrome: an inflammatory disease?. Neonatology, 99(4), 316-319 Monfredini, ... It is the fetal heart and not the mother's heart that builds up the fetal blood pressure to drive its blood through the fetal ... Remnants of the fetal circulation can be found in the adult. The core concept behind fetal circulation is that fetal hemoglobin ... The function of these shunts is to bypass the lungs and maintain proper circulation to important fetal tissue. In the fetal ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 103 (3): F208-F215. doi:10.1136/archdischild-2017-312748. PMC ... Fetal viability depends largely on the fetal organ maturity, and environmental conditions. According to Websters Encyclopedic ... That stage of fetal development when the life of the unborn child may be continued indefinitely outside the womb by natural or ... Fetal viability is the ability of a human fetus to survive outside the uterus. Medical viability is generally considered to be ...
"The risk of maternal parvovirus B19 infection during pregnancy on fetal loss and fetal hydrops: A systematic review and meta- ... Fifth Disease is most prevalent in children aged 5 to 15 years old. Fifth disease occurs at lower rates in adults. The virus ... It, or a disease presenting similarly, was first described by Robert Willan in his book On Cutaneous Diseases in 1808 as " ... The name "fifth disease" comes from its place on the standard list of rash-causing childhood diseases, which also includes ...
Centers for Disease Control and Prevention. "Facts About FASDs". Alcohol Use in Pregnancy , FASD , NCBDDD , CDC. 9 August 2017 ... leading to unhealthy outcomes for fetal development such as poor or slow fetal growth, and increasing fetal morbidity and ... The most severe of these is fetal alcohol syndrome. Fetal exposure to prenatal tobacco smoke may experience a wide range of ... Environmental toxicants and fetal development is the impact of different toxic substances from the environment on the ...
Fetal mortality refers to stillbirths or fetal death. It encompasses any death of a fetus after 20 weeks of gestation or 500 gm ... Fanaroff and Martin (eds.) Neonatal-perinatal medicine: Diseases of the fetus and infant; 7th ed. (2002):1001-1011. St. Louis: ... and the PNM may only include late fetal death and neonatal death. Fetal death can also be divided into death prior to labor, ... "NVSS - Fetal Deaths". www.cdc.gov. 8 November 2017. "Ending Newborn Deaths" (PDF). "Million babies die a year - charity - IOL ...
Fetal and Neonatal Edition. 87 (2): F122-F124. doi:10.1136/fn.87.2.F122. PMC 1721448. PMID 12193519. (Online version required ... Pharoah PO, Price TS, Plomin R (September 2002). "Cerebral palsy in twins: a national study". Archives of Disease in Childhood ... "High resorption rates, which cannot be explained on the basis of the expected abortion rate, suggest intense fetal competition ... Peleg, Dan; Ferber, Asaf; Orvieto, Raoul; Bar-Hava, Itai; Ben-Rafael, Zion (October 1998). "Single intrauterine fetal death ( ...
Fetal and Neonatal Edition. 99 (1): F87-92. doi:10.1136/archdischild-2012-303351. PMC 4239122. PMID 23960141. Horner P, Blee K ... Many species are sexually transmitted and cause pelvic inflammatory disease. Mycoplasma refers to a genus of bacteria that lack ... Their role in neonatal disease and adverse pregnancy outcomes has been well established, and semantic classifications are ... Viscardi RM (January 2014). "Ureaplasma species: role in neonatal morbidities and outcomes". Archives of Disease in Childhood. ...
The intensity of this fetal disease ranges from mild to very severe, and fetal death from heart failure (hydrops fetalis) can ... Murray NA, Roberts IA (March 2007). "Haemolytic disease of the newborn". Archives of Disease in Childhood. Fetal and Neonatal ... Exchange transfusion Rh disease Alloimmunization Hemolytic disease of the newborn (anti-Kell) Hemolytic disease of the newborn ... When the disease is moderate or severe, many erythroblasts (immature red blood cells) are present in the fetal blood, earning ...
Diseases that negatively affect kidney function can also have the same effect and thus warrant similar considerations. A major ... Fetal and Neonatal Edition. 73 (1): F51-F52. doi:10.1136/fn.73.1.f51. PMC 2528358. PMID 7552600. Elgood, Cyril (2010). A ... ISBN 978-1-108-01588-2. By writing a monograph on 'Diseases in Children' he may also be looked upon as the father of ... p. 1. Dunn, P. M. (1995). "Soranus of Ephesus (Circa AD 98-138) and perinatal care in Roman times". Archives of Disease in ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 91 (6): F454-9. doi:10.1136/adc.2005.092445. PMC 2672766. PMID ... Chronic obstructive pulmonary disease (COPD) Neuromuscular diseases or interstitial lung disease Malformed vascular system such ... Diseases such as peripheral vascular disease can also result in local hypoxia. Symptoms are worse when a limb is used, ... These diseases share a common feature that limitation of oxygen availability contributes to the development of the pathology. ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 83 (1): F48-F49. doi:10.1136/fn.83.1.F48. PMC 1721104. PMID ... Fetal and Neonatal Edition. 88 (5): F359-F364. doi:10.1136/fn.88.5.F359. PMC 1721612. PMID 12937037. Guida JD, Kunig AM, Leef ... "Niemann-Pick disease". Genetics Home Reference. U.S. National Library of Medicine. "Niemann-Pick - Symptoms and causes". Mayo ... A person with this disease may also complain of malaise, fatigue, and general weakness (with or without accompanying blood loss ...
Dunn, P. M. (September 2004). "Dunn". Archives of Disease in Childhood. Fetal and Neonatal Edition. 89 (5): F465-F467. doi: ... The sliding mechanism at the articulation can be helpful in asynclitic births (when the fetal head is tilted to the side), ... Christian Kielland of Oslo (1871-1941) and his straight forceps". Arch Dis Child Fetal Neonatal Ed. UK. 89 (10): 465-467. doi: ... since the fetal head is no longer in line with the birth canal.[medical citation needed] He was born in the Colony of Natal as ...
Heird WC (November 2004). "Taurine in neonatal nutrition--revisited". Archives of Disease in Childhood. Fetal and Neonatal ... Seminars in Fetal & Neonatal Medicine, 1(1): 19-26 (February 1996). Institute of Medicine; Food Nutrition Board; Committee on ... Friedenwald J, Ruhrah J (1910). Diet in Health and Disease. New York: W.B. Saunders Co. Marriott WM, Schoenthal L (1929). "An ... One of the main global risks posed by breast milk specifically is the transmission of HIV and other infectious diseases. ...
Fetal antigen status can be tested as early as 15 weeks by PCR of fetal cells. CVS is possible as well to test fetal antigen ... Murray, N. A; Roberts, I. A G (2007). "Haemolytic disease of the newborn". Archives of Disease in Childhood: Fetal and Neonatal ... Archives of Disease in Childhood: Fetal and Neonatal Edition. 88 (1): F6-10. doi:10.1136/fn.88.1.F6. PMC 1755998. PMID 12496219 ... "Fetal genotyping for the K (Kell) and Rh C, c, and E blood groups on cell-free fetal DNA in maternal plasma". Transfusion. 47 ( ...
Autoimmune disease may cause abnormalities in embryos, which in turn may lead to miscarriage. As an example, Celiac disease ... Fetal death after 20 weeks of gestation is also known as a stillbirth. The most common symptom of a miscarriage is vaginal ... certain infectious diseases, and autoimmune diseases. PCOS may increase the risk of miscarriage. Two studies suggested ... Other diseases are also known to make animals susceptible to miscarriage. Spontaneous abortion occurs in pregnant prairie voles ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 72 (1): F3-7. doi:10.1136/fn.72.1.f3. PMC 2528410. PMID 7743281. ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 93 (3): F246-8. doi:10.1136/adc.2006.104448. PMID 18426926. S2CID ... Weech AA (1970). "The guilding lamp of history". American Journal of Diseases of Children. 119 (3): 199. doi:10.1001/archpedi. ... Forbes GB (December 1972). "A. Ashley Weech, MD". American Journal of Diseases of Children. 124 (6): 818-9. doi:10.1001/ ... ISBN 1-4000-8214-5. Oxford Handbook of Infectious Diseases and Microbiology. OUP Oxford. 2009. p. 56. ISBN 9780191039621. Lesch ...
It is recommended only as a third line treatment in graft-versus-host-disease in adults because of lack of efficacy and side ... Fetal and Neonatal Edition. 80 (2): F142-4, discussion F144-5. doi:10.1136/fn.80.2.F142. PMC 1720896. PMID 10325794. "The ... It is used as a second-line treatment to manage graft versus host disease and aphthous stomatitis in children and has been ... Use of thalidomide in pregnancy can cause fetal abnormalities such as phocomelia (malformation of the limbs). In males who are ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 81 (1): F10-4. doi:10.1136/fn.81.1.F10. PMC 1720965. PMID ... These range from social deprivation, genetic and metabolic diseases, immune disorders, infectious diseases, nutritional factors ... Fetal Alcohol Spectrum Disorders (FASD) can exhibit a combination of the above, most commonly ADHD, because of this, FASD is ... Fetal alcohol syndrome: guidelines for referral and diagnosis (PDF). Archived 2009-04-23 at the Wayback Machine CDC (July 2004 ...
Demicheva E, Crispi F (2014). "Long-term follow-up of intrauterine growth restriction: cardiovascular disorders". Fetal ... Coronary Artery Disease (also known as coronary heart disease or ischemic heart disease) is a result of the build-up of ... Cardiovascular disease (CVD) is an umbrella term for a wide range of diseases affecting the heart and blood vessels, including ... The Centers for Disease Control and Prevention division of heart disease and stroke prevention initiated the Well-Integrated ...
Feldman, Gerald L; Weaver, D. D; Lovrien, E. W (1977). "The Fetal Trimethadione Syndrome". American Journal of Diseases of ... Onkal, R; Djamgoz, M. B (2009). "Molecular pharmacology of voltage-gated sodium channel expression in metastatic disease: ... Disease. 4 (6): e652. doi:10.1038/cddis.2013.174. PMC 3698542. PMID 23744352. Pei, L; Wiser, O; Slavin, A; Mu, D; Powers, S; ... Neurobiology of Disease. 73: 418-27. doi:10.1016/j.nbd.2014.09.005. PMID 25251605. S2CID 207068577. Watanabe, M; Iwashita, M; ...
Fasano RM (February 2016). "Hemolytic disease of the fetus and newborn in the molecular era". Seminars in Fetal & Neonatal ... Rh disease (also known as rhesus isoimmunization, Rh (D) disease, and blue baby disease) is a type of hemolytic disease of the ... Maitra A (2010). "Diseases of Infancy and Childhood". Robbins and Cotran Pathologic Basis of Disease. pp. 447-483. doi:10.1016/ ... However, this could only treat the disease after it took root and did not do anything to prevent the disease. In 1960, Ronald ...
Hunt RW (January 2005). "Etamsylate for prevention of periventricular haemorrhage". Archives of Disease in Childhood. Fetal and ... Archives of Disease in Childhood. Fetal and Neonatal Edition. 84 (3): F183-F187. doi:10.1136/fn.84.3.F183. PMC 1721248. PMID ... Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (1): F31-F35. doi:10.1136/adc.2003.035790. PMC 1721806. PMID ...
34-. ISBN 978-1-62703-179-0. Carrie Bagatell; William J. Bremner (27 May 2003). Androgens in Health and Disease. Springer ... 314-. ISBN 978-1-59259-388-0. Susan Blackburn (14 April 2014). Maternal, Fetal, & Neonatal Physiology. Elsevier Health Sciences ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 80 (3): F250-F251. doi:10.1136/fn.80.3.F250. PMC 1720922. PMID ... In breech presentation, fetal heart sounds are heard just above the umbilicus. Babies are usually born head first. If the baby ... General anesthesia is also preferred in very urgent cases, such as severe fetal distress, when there is no time to perform a ... Though vaginal birth is possible for the breech baby, certain fetal and maternal factors influence the safety of vaginal breech ...
Archives of Disease in Childhood. Fetal and neonatal edition. 78 (6): 548-551. doi:10.1136/adc.78.6.548. ISSN 1359-2998. PMC ... Alexander, Michael J.; Spetzler, Robert F. (October 2005). Pediatric Neurovascular Disease: Surgical, Endovascular, and Medical ... Archives of Disease in Childhood. 64 (12): 1653-1655. doi:10.1136/adc.64.12.1653. ISSN 0003-9888. PMC 1792909. PMID 2696431. ... "Prenatal Diagnosis of Unusual Fetal Pial Arteriovenous Malformation". Interv Neuroradiol. 9 (2): 163-8. doi:10.1177/ ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (4): F343-4. doi:10.1136/adc.2004.062588. PMC 1721902. PMID ... Retrieved 8 June 2023 - via U.S. Centers for Disease Control and Prevention. "nasal cannula". Medical Dictionary. 2009. ... Tiep, B.; Carter, R. (2008). "Oxygen conserving devices and methodologies". Chronic Respiratory Disease. crd.sagepub.com. 5 (2 ... "Personal Protective Equipment: Questions and Answers". Centers for Disease Control and Prevention. 11 February 2020. Archived ...
Archives of Disease in Childhood. Fetal and Neonatal Edition. 90 (4): F343-4. doi:10.1136/adc.2004.062588. PMC 1721902. PMID ... January 1987). "Is chronic lung disease in low birth weight infants preventable? A survey of eight centers". Pediatrics. 79 (1 ...
However, advances in ultrasound technology have enabled earlier and more precise diagnosis of human fetal cardiac lesions; this ... encoded search term (Fetal Intervention for Congenital Heart Disease) and Fetal Intervention for Congenital Heart Disease What ... Fetal Treatment 2017: The Evolution of Fetal Therapy Centers - A Joint Opinion from the International Fetal Medicine and ... Suguna Ganesan, MD Fellow in Fetal Cardiology, Department of Fetal Cardiovascular Ultrasound and Fetal Treatment, University of ...
Tonate Virus and Fetal Abnormalities, French Guiana, 2019. Emerging Infectious Diseases. 2022;28(2):445-448. doi:10.3201/ ... Fetal autopsy identified a male fetus, small for 22 weeks of gestation, with dysmorphism and fetal akinesia deformation ... Lambert specializes in fetal medicine at the West French Guiana Hospital Center, French Guiana, France. Her work focuses on ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
... and studies have shown that these individuals have an increased risk of developing a number of adult diseases. ... Fetal programming of adult disease. The early life environment has a large impact on a healthy start to life and long term ... La Trobe University > Department of Microbiology, Anatomy, Physiology and Pharmacology > Our research > Fetal programming of ... and studies have shown that these individuals have an increased risk of developing a number of adult diseases. ...
... coronary-artery disease, and non-insulin-dependent diabetes (NIDDM). A suggested explanation for this association is ... The predisposition to NIDDM and vascular disease is likely to be the result of both genetic and fetal environmental factors. ... The fetal insulin hypothesis: an alternative explanation of the association of low birthweight with diabetes and vascular ... Monogenic diseases that impair sensing of glucose, lower insulin secretion, or increase insulin resistance are associated with ...
Bench marking and performance management in neonatal care: easier said than done! Arch Dis Child Fetal Neonatal Ed2002;87:F163- ... USING DISEASE SCORES FOR GROUP PREDICTIONS AND FOR COMPARING UNITS. For comparison of outcomes across different neonatal ... In addition to comparing mortality-for example, in Scotland and Australia14-disease severity scores have also been used to ... The strengths and weaknesses of the existing methods of disease severity correction in the newborn are presented in this review ...
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... that women in India with lupus have low risk of a major flare during pregnancy when conception happens during a time of disease ... HPD is a risk factor independent of lupus disease activity, and it is strongly associated with poor fetal outcomes, ... New Data on Lupus Disease Activity and Maternal and Fetal Health Risks during Pregnancy. ... significant disease activity) during their pregnancy when conception happens during a time of disease stability. Only about 4% ...
... and Perinatal Disease published on Jul 1977 by The American Society of Tropical Medicine and Hygiene. ... Prevention of Embryonic, Fetal, and Perinatal Disease edited by Robert L. Brent and Maureen I. Harris. xi + 411 pages, ...
Your Name) thought you would like to see this page from the Archives of Disease in Childhood web site. ... Dermatoglyphics, fetal growth, and insulin dependent diabetes in children under 5 years. ... Dermatoglyphics, fetal growth, and insulin dependent diabetes in children under 5 years. ... Dermatoglyphics, fetal growth, and insulin dependent diabetes in children under 5 years. ...
Glutathione supplementation decreases mortality and congenital heart disease in an avian model of fetal alcohol spectrum ... Glutathione supplementation decreases mortality and congenital heart disease in an avian model of fetal alcohol spectrum ... PAE can result in fetal alcohol spectrum disorder (FASD). Recent reports have revealed high prevalence of FASD ( ≥1%), rivaling ...
The most important predictor of fetal growth restriction is underlying maternal vascular disease. Specifically, pregnant ... Various fetal biophysical tests can ensure that the fetus is well oxygenated, including fetal heart rate testing, fetal ... Surging maternal and fetal glucose levels are accompanied by episodic fetal hyperinsulinemia. Fetal hyperinsulinemia promotes ... including fetal heart rate testing, fetal movement assessment, ultrasonographic biophysical scoring, and fetal umbilical ...
Fetal vaccinia. Rarely, smallpox vaccination of a pregnant woman can result in fetal vaccinia. Transmission to the fetus can ... Content source: Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases ( ... Postvaccinial central nervous system disease. Postvaccinial central nervous system disease such as postvaccinial encephalitis ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ...
Infectious diseases of the fetus and newborn infant / [edited by] Jack S. Remington, Jerome O. Klein. by Remington, Jack S , ... Perinatal diseases / by 14 authors ; edited by Richard L. Naeye, John M. Kissane and Nathan Kaufman. by Naeye, Richard L , ... Fetal physiology and medicine : the basis of perinatology / edited by Richard W. Beard and Peter W. Nathanielsz. by Beard, ... Risk factors in pregnancy and diseases of the fetus and newborn / Richard L. Naeye, Nebiat Tafari. by Naeye, Richard L , Tafari ...
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However, advances in ultrasound technology have enabled earlier and more precise diagnosis of human fetal cardiac lesions; this ... encoded search term (Fetal Surgery for Congenital Heart Disease) and Fetal Surgery for Congenital Heart Disease What to Read ... Suguna Ganesan, MD Fellow in Fetal Cardiology, Department of Fetal Cardiovascular Ultrasound and Fetal Treatment, University of ... Fetal Surgery for Congenital Heart Disease. Updated: Feb 27, 2015 * Author: Anita J Moon-Grady, MD, FACC, FAAP, FASE; Chief ...
The cellular therapies aim to replace the missing neurons with dopamine-producing (dopaminergic) cells from fetal brains or ... team will next month transplant cells from aborted human fetuses into the brain of a person with Parkinsons disease. But the ...
Gaucher disease is an inherited disorder that affects many of the bodys organs and tissues. Explore symptoms, inheritance, ... Fetal Pediatr Pathol. 2005 Jul-Oct;24(4-5):205-22. doi: 10.1080/15227950500405296. Citation on PubMed ... Type 1 Gaucher disease is the most common form of this condition. Type 1 is also called non-neuronopathic Gaucher disease ... Type 2 Gaucher disease usually causes life-threatening medical problems beginning in infancy. Type 3 Gaucher disease also ...
FURLAN, Fabiola Luciana de Paula et al. Depression on pregnant woman with heart disease and its influence on maternal-fetal ... Keywords : Cardiac disease; Depression; Pregnancy; Maternal-fetal bond. · abstract in Portuguese · text in Portuguese · ... the existent of maternal-fetal bond and to verify if the maternal-fetal bond can be a risk factor for depression in pregnant ... Method: We interviewed 20 pregnant women with heart disease, being 10 of clinic and 10 hospitalized in the nursery of the ...
... you will be able to describe the exposure-disease model. ... Agency for Toxic Substance and Disease Registration. Search × ... fetal life,. *infancy,. *childhood, and. *adolescence.. Considerations include increased exposures and increased ... Clinical Disease. Many factors determine whether a person exposed to a toxic substance develops a clinical disease. Among these ... The Exposure-disease Model. No matter how toxic, no chemical can harm a person (child, adult, or both) unless exposure occurs. ...
How Karina is using her research grant to diagnose foetal heart disease. Since 2019, we have worked in partnership with the ... Aortopathy, that is diseases of the aorta, seen in several inherited diseases, such as Marfan syndrome, can lead to reshaping ... I want to continue studying foetal aorta. This project is the beginning of a field of study, foetal aortopathy. Then, we want ... Bake Off Baking Challenge event Christmas Congenital heart disease craft Fundraiser Fundraising Harefield Harefield Hospital ...
Hirschsprung Disease. View All Conditions * NICU Parent Booklet. Access resources for you to use during your babys hospital ...
Centers for Disease Control and Prevention. Naima T. Joseph MD, MPH. Division of Maternal Fetal Medicine. Department of ... CPE: The Centers for Disease Control and Prevention designated this (Knowledge-based) event for pharmacists to receive 0.1 CEUs ... CEU: The Centers for Disease Control and Prevention is authorized by IACET to offer 0.1 CEUs for this program. ... For Certified Public Health Professionals (CPH): The Centers for Disease Control and Prevention is a pre-approved provider of ...
The benefit of fetal echocardiograms (FE) to detect severe congenital heart diseases (SCHD) in the setting of a normal second- ... Incremental Detection of Severe Congenital Heart Disease by Fetal Echocardiography Following a Normal Second Trimester ... Cardiopatias Congênitas Ultrassonografia Pré-Natal Canadá Ecocardiografia Feminino Coração Fetal/anormalidades Coração Fetal/ ...
Early origins of disease: Non-fetal. / Hoffman, Daniel J.; Sommer, Alessandra D. Encyclopedia of Human Nutrition: Volume 1-4, ... Early origins of disease: Non-fetal. In Encyclopedia of Human Nutrition: Volume 1-4, Fourth Edition. Vol. 1-4. Elsevier. 2023. ... Hoffman, D. J., & Sommer, A. D. (2023). Early origins of disease: Non-fetal. In Encyclopedia of Human Nutrition: Volume 1-4, ... Hoffman, Daniel J. ; Sommer, Alessandra D. / Early origins of disease : Non-fetal. Encyclopedia of Human Nutrition: Volume 1-4 ...
Age-Adjusted Death Rates for Alzheimer Disease Among Adults Aged ≥65 Years, by Sex - National Vital Statistics System, United ... Categories Alzheimers disease, Deaths, elderly, mortality, QuickStats, Vital Statistics Rapid Release, Vital Statistics System ... The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. ... Centers for Disease Control and Prevention. CDC twenty four seven. Saving Lives, Protecting People ...
Recent Patterns in Heart Disease and Cancer Mortality - Featured Topics from the National Center for Health Statistics ... MH: Despite a narrowing of the gap between heart disease and cancer deaths over time, especially since the 1980s, heart disease ... cancer deaths have been increasing more than heart disease deaths. Cancer replaced heart disease as the leading cause of death ... Q: Where do heart disease and cancer rank as leading causes of death at the state level, and how has that changed over the ...
  • Clinicians should be made aware of possible adverse fetal outcomes in pregnant women infected with Tonate virus. (cdc.gov)
  • HPD is a risk factor independent of lupus disease activity, and it is strongly associated with poor fetal outcomes, particularly stillbirth, prematurity and need for caesarean section. (lupus.org)
  • Overall, more than half (58%) of the pregnancies resulted in poor fetal outcomes. (lupus.org)
  • Fewer than half (46.8%) of the women who conceived while their lupus was in remission experienced poor fetal outcomes, and the researchers found that disease activity during conception was associated with a three-fold increased risk of adverse fetal outcomes. (lupus.org)
  • The exposure-disease model is often used to conceptualize how toxicant exposure occurs and to identify the steps necessary to cause disease or other adverse health or developmental outcomes. (cdc.gov)
  • As well, early postnatal growth trajectories are more associated with adult disease outcomes and there is strong evidence that rapid postnatal growth can amplify the effects of retarded fetal growth. (researchwithrutgers.com)
  • There were 13 cases (8.6%) of congenital heart diseases and 17 (11.3%) of valvular heart diseases (1 case of severe pulmonary stenosis) all with good outcomes. (romanianjournalcardiology.ro)
  • The study objective is to compare neurodevelopmental (ND) and behavioral outcomes between children with Down syndrome (DS) who had complete atrioventricular septal defect (CAVSD) repair and children from the same clinical sites with DS without major congenital heart disease (CHD) requiring previous or planned CHD surgery. (nih.gov)
  • Our findings with PinT and other intracellularly induced [small RNAs] illustrate how small perturbations in the infection process, such as dysregulation of a few Salmonella mRNAs, can propagate through the entire host system, potentially leading to different disease outcomes in the context of a whole organism," the researchers concluded. (genomeweb.com)
  • Objective: This retrospective cohort study describes the modulation of disease activity during gestation and in the year following delivery as well as maternal and neonatal outcomes in a monocentric cohort of women with juvenile idiopathic arthritis (JIA).Methods: Disease activity was assessed using DAS28-CRP before conception and every 3 months during pregnancy and in the first year postpartum. (unimi.it)
  • Adjusted for breastfeeding and DAS28-CRP score in the third trimester, postconceptional exposure to biologics was inversely related with disease activity in the postpartum: the longer the patient continued treatment, the lower the probability of experiencing an adverse pregnancy outcome.Conclusion: These data offer novel insights on how treatment affects disease activity during pregnancy and postpartum as well as obstetric outcomes in women with JIA. (unimi.it)
  • Centers for Disease Control and Prevention. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) and the American College of Obstetrics and Gynecology (ACOG) continue to emphasize the importance of vaccinations for pregnant people. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. (cdc.gov)
  • The Centers for Disease Control and Prevention (CDC) studies show FAS occurring in 0.2 to 1.5 infants for every 1,000 live births in certain areas of the US, with the most recent study finding FAS in 0.3 out of every 1,000 children from 7-9 years old [8] [9] . (aao.org)
  • [ 1 ] Although initial research showed promise, the fetoplacental response to bypass was characterized by cytokine activation, endothelial dysfunction, and increased resistance in the placenta, with fetal hypoxia and demise as end results. (medscape.com)
  • [ 1 ] Although initial research showed promise of reproducibility in technique, the fetoplacental response to bypass, characterized by an end result of fetal hypoxia and demise, deterred complete success. (medscape.com)
  • The earliest reported human fetal cardiac therapy of any kind took place in 1975 and involved maternal-fetal transplacental administration of a beta blocker in the setting of fetal ventricular tachyarrhythmia. (medscape.com)
  • Royal Brompton has a foetal cardiology centre, which is known worldwide. (rbhcharity.org)
  • A newly published study finds that women in India with lupus have a low risk of experiencing a major flare (i.e., significant disease activity) during their pregnancy when conception happens during a time of disease stability. (lupus.org)
  • Use of the medication hydroxychloroquine (also known as Plaquenil) was also associated with decreased risk of disease flares during pregnancy in women in remission at the time of conception. (lupus.org)
  • Since risk of pregnancy complications and lupus flares partly depends on the population studied, these latest findings add important new insights into maternal and fetal health risks among women with lupus around the world. (lupus.org)
  • For the best outcome, preplan pregnancy in consultation with you doctor when (your) lupus (disease) is stable and you are on treatment with safe medications. (lupus.org)
  • Risk factors in pregnancy and diseases of the fetus and newborn / Richard L. Naeye, Nebiat Tafari. (who.int)
  • It is starting to replace the more invasive and riskier tests for detecting fetal abnormalities that are often inaccurate and can only be done during later stages of pregnancy. (genomeweb.com)
  • Genomic microarray can detect ROH, which may indicate an increased risk for autosomal recessive (AR) disease for genes contained within the ROH, and/or the risk of an imprinting disorder due to uniparental disomy (UPD), or molar pregnancy. (arupconsult.com)
  • Although with increasing incidence, preexistent or newly induced cardiovascular diseases are still underdiagnosed in pregnancy. (romanianjournalcardiology.ro)
  • A local prospective registry on cardiovascular diseases in pregnancy. (romanianjournalcardiology.ro)
  • Fetal Alcohol Syndrome (FAS) is an irreversible congenital condition that is a result of maternal alcohol use during pregnancy [1] . (aao.org)
  • PE not only affects the foetus, generating complications during pregnancy but also predisposes them to chronic diseases in adulthood. (biomedcentral.com)
  • However, in the third trimester of pregnancy, which is also when foetal growth is greatest, overall LPL activity decreases, coupled with increased lipolytic and catabolic activity due to insulin resistance that occurs at the time of pregnancy [ 11 ]. (biomedcentral.com)
  • This becomes of importance when it is well established that poor fetal growth is associated with an increased risk for chronic diseases in adulthood (cardiovascular disease, type II diabetes, atherosclerosis). (sciencedaily.com)
  • During the 2019 rainy season, a 33-year-old woman living in the Bas Maroni region of French Guiana was referred to the prenatal diagnosis unit at West French Guiana Hospital Center (Saint-Laurent-du-Maroni, French Guiana) for fetal anomalies. (cdc.gov)
  • The software is designed to analyze whole-genome sequence data from samples of cell-free DNA (cfDNA) extracted from maternal blood plasma, one of the newer and less invasive forms of prenatal genetic testing that are becoming more commonly used to screen fetuses for heritable genetic diseases and identify abnormalities. (genomeweb.com)
  • It is the recommended first-tier test for patients undergoing prenatal diagnosis for the indication of a fetal structural abnormality detected by ultrasound (unless the structural abnormality is strongly suggestive of a specific aneuploidy, in which case, karyotype with or without fluorescence in situ hybridization [FISH] may be offered before genomic microarray). (arupconsult.com)
  • Due to high carrier rates and the severity of the disease, population screening and prenatal diagnosis of Tay-Sachs disease are routinely carried out in Israel. (tau.ac.il)
  • The assay of hexosaminidase A (Hex A) activity is carried out with synthetic substrates, 4-methylumbelliferyl-6-sulfo-N-acetyl-β- glucosaminide (4-MUGS) and 4-methylumbelliferil-N-acetyl-β-glucosamine (4-MUG), and the DNA-based analysis involves testing for the presence of specific known mutations in the α-subunit gene of Hex A. Prenatal diagnosis of Tay-Sachs disease is accomplished within 24-48∈h from sampling. (tau.ac.il)
  • In the years since that landmark paper, however-in large part as a consequence of technical and scientific advances in maternal-fetal medicine, surgical technique, and fetal echocardiography-fetal therapy has also grown to include fetal cardiac intervention (FCI). (medscape.com)
  • Objective: To evaluate the presence or not of depression, the existent of maternal-fetal bond and to verify if the maternal-fetal bond can be a risk factor for depression in pregnant women with heart disease. (bvsalud.org)
  • Maternal-fetal bond. (bvsalud.org)
  • Our Maternal-Fetal Medicine Specialists, or "Perinatologists," have the training and expertise to care for these complicated pregnancies. (utmb.edu)
  • After completing their Ob/Gyn training, Maternal-Fetal Medicine Specialists undergo three years of extra training to teach them to deal with even the most complex pregnancies. (utmb.edu)
  • Although many general obstetrician-gynecologists have experience caring for high-risk pregnancies, there are times when consultation with, or turning the care over to, one of our Maternal-Fetal Medicine Specialists can make all the difference for a mother, baby, or both! (utmb.edu)
  • Maternal-Fetal Medicine Specialists at UTMB have written the textbooks and guidelines that others use when caring for pregnant women and their babies. (utmb.edu)
  • Dr. Gary Fruhman, MD is a Maternal-Fetal Medicine Specialist in Staten Island, NY. (sharecare.com)
  • People with the cardiovascular form of Gaucher disease may also have eye abnormalities, bone disease, and mild enlargement of the spleen (splenomegaly). (medlineplus.gov)
  • For other fetal testing to detect cytogenetic abnormalities, refer to the Laboratory Test Directory . (arupconsult.com)
  • Examples of cases with newborns who with sustained fetal circulation are pulmonary hypoplasia and genetic abnormalities. (wikipedia.org)
  • Decades of research now support the concept that specific chronic diseases of adulthood have origins in utero or during early childhood. (researchwithrutgers.com)
  • Many experimental studies have been conducted to explain the phenotypic consequences of fetal-placental perturbations that predispose to the genesis of metabolic syndrome, obesity, diabetes, hyperinsulinemia, hypertension, and cardiovascular disease in adulthood. (unipr.it)
  • The objective of the review was to analyse the information the current information about exists about the impact generated by the oxidation of LDL and HDL lipoproteins in neonates of women with preeclampsia and how these alterations can predispose the neonate to develop diseases in adulthood. (biomedcentral.com)
  • Fetal development is a critical window of exposure-related susceptibility because the etiology of diseases in adulthood may have a fetal origin and may be attributed to adverse effects of in utero environmental exposures. (nature.com)
  • Fetal physiology and medicine : the basis of perinatology / edited by Richard W. Beard and Peter W. Nathanielsz. (who.int)
  • Given the now substantial body of knowledge regarding the fetal physiology and natural history of these lesions in utero and the success of balloon aortic and pulmonary valvuloplasty in preventing or reversing newly onset ventricular dysfunction postnatally in infants, there is a theoretical rationale for intervention to relieve valvar stenosis or to enlarge a restrictive atrial septal opening in fetal life. (medscape.com)
  • The goal of this study is to evaluate the impact of abnormal fetal cerebrovascular physiology with neurodevelopmental delay. (nih.gov)
  • In the 1980s, a foetal programming concept emerged that suggested that the intrauterine environment determines and programmes physiology and metabolism throughout life [ 8 ]. (biomedcentral.com)
  • Fetal and neonatal pathology : perspectives for the general pathologist / edited by A. J. Barson on behalf of the Royal College of Pathologists. (who.int)
  • [ 14 ] They also suggest that successful fetal procedures lead to improvement in functional chamber development and myocardial function while the fetus is still in utero. (medscape.com)
  • Reproductive-rights opponents point to premature neonates as evidence of pain in a fetus, but the RCOG analysis found good evidence that conditions within the womb distinguish fetal experience of sensation from those of premature infants of similar gestational age. (medscape.com)
  • The researchers have since recorded ultrasound images of a model human fetus that is traditionally used in the testing of fetal ultrasound imaging devices. (medgadget.com)
  • Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life onwards. (nature.com)
  • 10% of all births) is a large problem in Western society, and studies have shown that these individuals have an increased risk of developing a number of adult diseases. (edu.au)
  • The purpose of this study is to evaluate the feasibility and preliminary efficacy of the Promoting Resilience in Stress Management (PRISM) intervention in patients with adult congenital heart disease. (nih.gov)
  • This research study is being done to provide comparative data to the Mayo Clinic Adult Congenital Heart Disease Registry. (nih.gov)
  • Paradoxically, pediatricians must feel involved in fighting this condition because of the latest evidences of developmental origins of adult diseases. (unipr.it)
  • Relation of fetal and infant growth to adult eye disease .2. (ox.ac.uk)
  • Polycystin, the polycystic kidney disease 1 protein, is expressed by epithelial cells in fetal, adult, and polycystic kidney. (ox.ac.uk)
  • In fetal and adult kidney, staining is restricted to epithelial cells. (ox.ac.uk)
  • Fetal therapy is a broad term that encompasses a range of transplacental medications, catheter-based interventions, fetoscopic procedures, minimally invasive fetoscopic surgical procedures, open fetal surgical procedures, and ex-utero intrapartum treatment (EXIT) procedures. (medscape.com)
  • this technology has also enabled the field of congenital heart disease to gain greater understanding of the unique fetal hemodynamics and the mechanisms involved in the evolution of cardiac disease in utero. (medscape.com)
  • [ 19 ] However, much effort must be applied to appropriate planning and selection of candidates (maternal and fetal) to minimize the obvious complications and risks associated with in-utero interventions. (medscape.com)
  • Placenta assumes a pivotal role in programming the fetal experience in utero due to the adaptive changes in structure and function. (unipr.it)
  • In the words of the authors, "it is plausible that in utero telomere biology represents a molecular mechanism whereby stress exposure in this critical period before birth can impact aging and subsequent disease susceptibility over the lifespan. (theprimalmind.com)
  • The Maternal Stress Shortens Fetal Telomeres and Programs Aging and Disease In Utero by The Primal Mind , unless otherwise expressly stated, is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 2.5 Canada License . (theprimalmind.com)
  • However, among the 10 leading causes of death in the United States, New Mexico has mortality rates that are lower than the U.S. rates for the following causes: heart disease, cancer, stroke, Alzheimer's disease, influenza/pneumonia and kidney disease. (cdc.gov)
  • However, among the 10 leading causes of death in the United States, the silver state has mortality rates that are lower than the U.S. rates for the following causes: cancer, stroke, Alzheimer's Disease and diabetes. (cdc.gov)
  • The International Statistical Classification of Disease and Related Health Problems (commonly referred to as the International Classification of Diseases, ICD) is the global standard classification for mortality and morbidity statistics. (who.int)
  • Extensive preparation was devoted to a review of the suitability of the structure of ICD, which was by definition a statistical classification of diseases and other health problems, to serve a wide variety of needs for mortality statistics, morbidity statistics, reimbursement, measuring quality of care, patients' safety, monitoring primary care and clinical recording. (who.int)
  • 2, 2021 Infectious diseases are a leading cause of global mortality. (sciencedaily.com)
  • for example, it is closely associated with fetal and neonatal mortality and morbidity, inhibited growth and cognitive development, and noncommunicable diseases ( NCD s) later in life. (who.int)
  • Regarding the depression diagnosis, the evaluation of Prime-MD showed that 90% of the women didn't present enough symptoms to characterize the disease. (bvsalud.org)
  • The three grant awardees selected this year by a panel of experts and advisors are: Karina Lopes, who aims to improve diagnosis of abnormal aortas in foetuses, Dr Carmel Stock , who wants to better predict the likelihood a patient with Scleroderma will go on to develop interstitial lung disease and Andreia Pinto , who will be researching how Covid-19 infects cells. (rbhcharity.org)
  • The Heart Center brings together a select group of specialists to offer extensive expertise in the diagnosis and treatment of infants and children with heart disease. (orlandohealth.com)
  • Mesenchymal hamartoma of the liver is a rare benign tumor of children, which definitive diagnosis during the fetal period remains difficult, despite advances in antenatal imaging. (rarejournal.org)
  • on follow up after delivery (120 patients), premature birth, fetal weight, Apgar score and deaths were recorded. (romanianjournalcardiology.ro)
  • Fetal hydrops is defined by the demonstration of fluid accumulations in at least two of these four fluid compartments.3 But the placenta and the amniotic sac have sometimes been included as additional "fetal compartments. (taylorfrancis.com)
  • Hence, particle translocation to the human placenta following inhalation under real-life conditions is insufficiently studied while being essential in understanding the effects on fetal health 24 . (nature.com)
  • Promote health improvement, wellness, and disease prevention in cooperation with patients, communities, at-risk populations, and other members of an interprofessional team of healthcare providers. (cdc.gov)
  • Experimental animal models of open fetal cardiac surgery began in the 1980s, with the aim of describing the physiologic and pathologic impacts of extracorporeal circulatory bypass. (medscape.com)
  • Experimental studies on open fetal cardiac surgery began in the 1980s in animal models to study the physiologic and pathologicl mechanisms of extracorporeal circulatory bypass. (medscape.com)
  • [ 15 , 16 ] as well as provided evidence that fetal valvuloplasty in conditions of atretic or stenotic valves of the aorta and pulmonary artery can facilitate the chance of biventricular circulation after birth, whereas septoplasty for intact or severely restrictive interatrial septum may improve postnatal stability and chances of survival after initial palliative surgery. (medscape.com)
  • We also have shown that fetal growth correlates with the hedonic responses to sweet taste in preterm newborns born at 27 weeks gestation. (sciencedaily.com)
  • Large hepatic mesenchymal hamartoma leading to mid-trimester fetal demise. (rarejournal.org)
  • Persistent fetal circulation in neonates can be reversible or irreversible depending on the classified etiology listed above. (wikipedia.org)
  • Incremental Detection of Severe Congenital Heart Disease by Fetal Echocardiography Following a Normal Second Trimester Ultrasound Scan in Québec, Canada. (bvsalud.org)
  • Low birthweight is associated with insulin resistance, hypertension, coronary-artery disease, and non-insulin-dependent diabetes (NIDDM). (nih.gov)
  • Dermatoglyphics, fetal growth, and insulin dependent diabetes in children under 5 years. (bmj.com)
  • If maternal diabetes is longstanding or associated with known microvascular disease, obtain a baseline maternal electrocardiogram (ECG) and echocardiogram. (medscape.com)
  • In the long term, overweight and obesity in children increase the risk of health problems later in life, including obesity, diabetes, heart disease, some cancers, respiratory disease, mental health and reproductive disorders. (who.int)
  • Persistent fetal circulation is a condition caused by a failure in the systemic circulation and pulmonary circulation to convert from the antenatal circulation pattern to the "normal" pattern. (wikipedia.org)
  • The failure of the circulatory system of the newborn to adapt to these changes by lowering PVR leads to persistent fetal circulation. (wikipedia.org)
  • A gradient of 10% or more in oxygenation saturation between simultaneous preductal and postductal arterial blood gas values in absence of structural heart disease documents persistent fetal circulation. (wikipedia.org)
  • Since this may be a sign of other conditions, persistent fetal circulation must also be characterized by enlargement of right and left ventricles often confirmed through a definitive ECG. (wikipedia.org)
  • Persistent fetal vasculature. (aao.org)
  • Therefore, a persistent alteration in food preferences in individuals exposed to fetal adversity possibly contributes to the development of these diseases. (sciencedaily.com)
  • Abnormal vascular development during fetal life and early childhood, as a result of genetic insulin resistance, could also explain the increased risk of hypertension and vascular disease. (nih.gov)
  • Future studies of PVD patterns can provide important insights into left atrial dynamics, pulmonary venous return and pulmonary vascular development in fetal HLHS. (bmj.com)
  • NEW YORK (GenomeWeb) - Researchers from the University of Toronto's computer science department and the genomics arm of Canada's Hospital for Sick Children have developed freely available open-source software that offers more statistically sensitive tools for identifying small de novo copy number variants in fetal DNA. (genomeweb.com)
  • This study is seeking to define and determine the prevalence of pulmonary vascular disease and diastolic dysfunction as assessed by the gold standard of invasive hemodynamic cardiopulmonary exercise testing. (nih.gov)
  • Intervention for cardiac defects fits into existing fetal care structures and is an extension of services and clinical research protocols related to fetal treatment. (medscape.com)
  • Owing to the complications of any intrauterine intervention, investing in innovative fetal treatment can be considered a useful exercise only when it is made feasible in terms of procedural ease and risks. (medscape.com)
  • Furthermore, local oversight should dictate whether, on procedure-based grounds, the proposed fetal intervention constitutes human subjects research, innovative therapy, or clinical care,as well as ensure that the appropriate counseling and consent procedures are followed. (medscape.com)
  • The purpose of this report is to describe what we believe to be the first case of fetal ascites, secondary to generalized cytomegalovirus infection proved by culture. (jamanetwork.com)
  • Some series of nonimmune hydrops also include cases of isolated pleural effusion, abdominal ascites, or generalized skin edema, because fluid accumulation in one site may represent an early stage of a disease that may lead to fluid accumulation in several sites at a more advanced stage, especially in diseases known to result in generalized hydrops fetalis. (taylorfrancis.com)
  • The NHLBI leads or sponsors studies for patients who have heart, lung, blood, or sleep related diseases or disorders. (nih.gov)
  • The exposure-disease model depicts the relationship between an environmental contaminant and an adverse health effect. (cdc.gov)
  • Another form of Gaucher disease is known as the cardiovascular type (or type 3c) because it primarily affects the heart, causing the heart valves to harden (calcify). (medlineplus.gov)
  • Method: We interviewed 20 pregnant women with heart disease, being 10 of clinic and 10 hospitalized in the nursery of the Obstetric Clinic Division - HCFMUSP, through the application of semi-driven interview and Prime-MD. Results: 75% of the patients interviewed reported positive aspects in relation to the feelings associated to the moment that the baby moves, what probably demonstrates a good mother-baby bond. (bvsalud.org)
  • Conclusion: Depression was not diagnosed among the pregnant woman with heart disease, what possibly links to a good mother-baby bond's development. (bvsalud.org)
  • One of them said that she was really happy that she agreed to have a foetal heart scan done, as it meant she knew that her baby had an abnormal aorta. (rbhcharity.org)
  • The benefit of fetal echocardiograms (FE) to detect severe congenital heart diseases (SCHD) in the setting of a normal second-trimester ultrasound is unclear. (bvsalud.org)
  • Congenital Heart Disease GEnetic NEtwork Study (CHD GENES). (nih.gov)
  • This study will find both common genetic causes of congenital heart disease and ways that genes influence results of medical treatment. (nih.gov)
  • To participate in this study, you or your child must have congenital heart disease. (nih.gov)
  • In addition, they note that diets containing omega-3s from fish could lower heart disease rates. (medicalnewstoday.com)
  • 3. In order to adequately respond to this high burden of disease and in line with the 2030 Agenda for Sustainable Development, WHO has developed a global health sector strategy on STIs, 2016-2021. (who.int)
  • Only subtype I varieties AB and C cause severe equine epizootics and human outbreaks marked by the occurrence of encephalitis and fetal damage ( 2 ). (cdc.gov)
  • The most severe type of Gaucher disease is a very rare form of type 2 called the perinatal lethal form. (medlineplus.gov)
  • PPHN can range from mild to severe disease. (wikipedia.org)
  • Kamath-Rayne BD, Saal H, Lang S, Habli M. Recurrent severe oligohydramnios and fetal pulmonary hypoplasia associated with ErbB4 mutation. (medscape.com)
  • PAE can result in fetal alcohol spectrum disorder (FASD). (aap.org)
  • FAS is a syndrome that falls under a larger group of conditions known as Fetal Alcohol Spectrum Disorder (FASD). (aao.org)
  • In other words, womb stress causes senescence of fetal and placental tissues which can trigger preterm birth. (theprimalmind.com)
  • Your Name ) thought you would like to see this page from the Archives of Disease in Childhood web site. (bmj.com)
  • There is substantial evidence that nutritional programming of later disease risk begins during infancy and childhood and may be mediated by several different factors, such as feeding regimes (especially breast-feeding versus artificial feeding) and growth trajectories. (researchwithrutgers.com)
  • 2024 ) In Archives of disease in childhood. (lu.se)
  • Neonates of mothers with PE have a high risk of cardiovascular diseases, stroke, mental retardation, sensory deficiencies and an increased risk of developing metabolic diseases. (biomedcentral.com)
  • Our study provides a paradigm for a sensitive RNA-based analysis of intracellular bacterial pathogens and their hosts without physical separation, as well as a new discovery route for hidden functions of pathogen genes," senior author Jörg Vogel, a molecular infection biology and infectious diseases researcher at the University of Würzburg, and colleagues wrote. (genomeweb.com)
  • Oxidative stress may be the general underlying mechanism that links altered placental function to fetal programming. (unipr.it)
  • One group at the University of Texas Medical Branch at Galveston correlated short fetal leukocyte telomere length with preterm prelabor rupture of the membranes and characterized the phenomenon as a "placental membrane disease likely mediated by oxidative stress-induced senescence. (theprimalmind.com)
  • Fetal pulmonary valvuloplasty (FPV) would not meaningfully change the clinical course for either of these two groups. (medscape.com)
  • Clinical disease: physical signs and symptoms resulting from a sufficiently absorbed toxicant dose. (cdc.gov)
  • Many factors determine whether a person exposed to a toxic substance develops a clinical disease. (cdc.gov)
  • I had been working as a foetal cardiologist in Brazil, but an opportunity arose to join the clinical group in 2020 as a research sonographer and I took it as I wanted to dedicate some time to research and studying. (rbhcharity.org)
  • The Center for Digestive Health and Nutrition provides clinical services to infants an children with symptoms of digestive problems and diseases. (orlandohealth.com)
  • Dr. Roy Baynes, senior vice president and head of global clinical development, chief medical officer, Merck Research Laboratories, said, "Building on the strong data we've seen with LYNPARZA to date, the data from SOLO-1 reinforce LYNPARZA's ability to provide meaningful disease control with a well-characterized safety and tolerability profile. (merck.com)
  • Even though this measure is not yet law-and hopefully will not become law-it is already planting seeds of confusion about fetal development during gestation, one of the most unfounded being the false existence of fetal pain in the second trimester. (medscape.com)
  • The predisposition to NIDDM and vascular disease is likely to be the result of both genetic and fetal environmental factors. (nih.gov)
  • Polycystic kidney disease 1 (PKD1) is the major locus of the common genetic disorder autosomal dominant polycystic kidney disease. (ox.ac.uk)
  • whose alleviation might allow fetal development to proceed normally. (medscape.com)
  • WHO, entrusted with ICD's development in 1948, extended its scope to include non-fatal diseases. (who.int)
  • Fetal programming occurs when the normal fetal development is disrupted by an abnormal insult applied to a critical point in intrauterine life. (unipr.it)
  • Research to be presented at the Annual Meeting of the Society for the Study of Ingestive Behavior (SSIB), the foremost society for research into all aspects of eating and drinking behavior, suggests that feeding behavior and preferences may be shaped very early during development, even during fetal life. (sciencedaily.com)
  • From development to disease. (medscape.com)
  • Definition The Greek-Latin term hydrops fetalis is issued for pathologically increased fluid accumulations in fetal soft tissues and serous cavities.1 Immune hydrops fetalis refers to those cases of hydrops that are caused by alloimmune hemolytic anemia in the presence of circulating maternal antibodies against fetal erythrocytes.2 If there is no evidence of blood group incompatibility (isoimmunization), the hydrops is characterized as being nonimmune hydrops fetalis. (taylorfrancis.com)
  • abstract = "Tay-Sachs disease is an autosomal recessive storage disease caused by the impaired activity of the lysosomal enzyme hexosaminidase A. In this fatal disease, the sphingolipid GM2 ganglioside accumulates in the neurons. (tau.ac.il)
  • The age-adjusted death rate for Alzheimer disease increased from 128.8 per 100,000 in 1999 to 233.8 in 2019. (cdc.gov)
  • 2019 ( https://www.who.int/nutrition/publications/UNICEF-WHOlowbirthweight-estimates-2019/en/ ). (who.int)
  • This causality concept is known as the Developmental Origins of Health and Disease or Barker hypothesis 1 . (nature.com)
  • In pregnant women hypertensive disease is the most frequent and with worse outcome cardio-vascular condition, yet treatable or even preventable with a right management including better risk scree-ning protocols, cardiological evaluation and Aspirin prophylaxis. (romanianjournalcardiology.ro)
  • Insulin secreted by the fetal pancreas in response to maternal glucose concentrations is a key growth factor. (nih.gov)
  • Monogenic diseases that impair sensing of glucose, lower insulin secretion, or increase insulin resistance are associated with impaired fetal growth. (nih.gov)
  • PE can cause foetal loss, intrauterine growth restriction, or developmental complications. (biomedcentral.com)
  • The NIH also report that taking supplementary omega-3s can reduce the risk of death from all health conditions and particularly from cardiovascular disease. (medicalnewstoday.com)
  • 1, 2, 4 - 6 However, since the late 1980s and early 1990s other microorganisms have dramatically emerged as very significant causes of fetal loss in mares. (veteriankey.com)
  • The early life environment has a large impact on a healthy start to life and long term disease risk. (edu.au)
  • Type 2 Gaucher disease usually causes life-threatening medical problems beginning in infancy. (medlineplus.gov)
  • Research on these topics is complicated by the fact that breast-feeding is associated with other maternal characteristics, such as education and socio-economic status, that will impact other aspects of a child's rearing that may themselves affect diseases of later life. (researchwithrutgers.com)
  • As more than 20 million children are born low birth weight annually worldwide, part of whom will become adults with the chronic diseases described above, the understanding of how early life may shape the individuals' eating behavior and preferences is of great importance. (sciencedaily.com)
  • These results suggest that polycystin's major role is in the maintenance of renal epithelial differentiation and organization from early fetal life. (ox.ac.uk)
  • As its name indicates, most infants with the perinatal lethal form of Gaucher disease survive for only a few days after birth. (medlineplus.gov)
  • In 1982, Harrison et al published a letter in the New England Journal of Medicine asserting that there were certain "simple [fetal] structural defects. (medscape.com)
  • A prompt and thorough interdisciplinary reference to cardiologist often improves the maternal and/or fetal outcome. (romanianjournalcardiology.ro)
  • 151 female patients (127 pregnant, 24 recent delivery) with known or suspected cardiac disease were referred to our cardiologist. (romanianjournalcardiology.ro)
  • As a result of low oxygen levels, infants with PPHN are at an increased risk of developing complications, such as asphyxia, chronic lung disease, neurodevelopment issues, and death. (wikipedia.org)